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Conserved domains on  [gi|928890061|ref|WP_053921598|]
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MULTISPECIES: universal stress protein [Enterobacteriaceae]

Protein Classification

universal stress protein( domain architecture ID 11100057)

universal stress protein (USP) enhances the rate of cell survival during prolonged exposure to stress agents

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
160-273 2.12e-22

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


:

Pssm-ID: 440354  Cd Length: 136  Bit Score: 89.98  E-value: 2.12e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928890061 160 RVMFAFDGSEESRRNLERLAMSPLLRGLECHLVMV-------------------NGKEEELLTAQQILRDAGIENSTTHL 220
Cdd:COG0589    4 RILVPTDGSEEAERALEYAAELAKALGAELHLLHVvdpppsaaagpeeleeelrEEAEEALEEAAERLEEAGVEVETVVR 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 928890061 221 TGqSVGDALIRYAEENAVDLIVMGAYGHSRLRQFFIGSHTSEMLQKTQQPLLI 273
Cdd:COG0589   84 EG-DPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 5-152 6.45e-14

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


:

Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 67.05  E-value: 6.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928890061    5 VTACVDGSLSTRSVCEYAAWAARTLQSQLALLHVIEKDSTPVVSDLTGTLGIDSQQLLTDELVEIEgqrnrllmvqgkai 84
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALA-------------- 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 928890061   85 ldscAELLQKQGTPDVLLMQKHGTPDEILTELSDLR---LMVLGRRG----SQHPVGSHLESVIRLQKKPLLVVP 152
Cdd:pfam00582  67 ----AAAAAEAGGVKVEVVVVVGDPAEEILEVAEEEdadLIVMGSRGrsglSRLLLGSVAEYVLRHAPCPVLVVR 137
 
Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
160-273 2.12e-22

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 89.98  E-value: 2.12e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928890061 160 RVMFAFDGSEESRRNLERLAMSPLLRGLECHLVMV-------------------NGKEEELLTAQQILRDAGIENSTTHL 220
Cdd:COG0589    4 RILVPTDGSEEAERALEYAAELAKALGAELHLLHVvdpppsaaagpeeleeelrEEAEEALEEAAERLEEAGVEVETVVR 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 928890061 221 TGqSVGDALIRYAEENAVDLIVMGAYGHSRLRQFFIGSHTSEMLQKTQQPLLI 273
Cdd:COG0589   84 EG-DPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 160-273 3.08e-22

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 89.33  E-value: 3.08e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928890061 160 RVMFAFDGSEESRRNLERLAMSPLLRGLECHLVMV--------------------NGKEEELL-TAQQILRDAGIENSTT 218
Cdd:cd00293    1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVvdpppssslsggleeladelKEEAEELLeEAKKLAEEAGVEVETI 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 928890061 219 HLTGqSVGDALIRYAEENAVDLIVMGAYGHSRLRQFFIGSHTSEMLQKTQQPLLI 273
Cdd:cd00293   81 VVEG-DPAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLV 134
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 161-275 5.36e-16

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 72.83  E-value: 5.36e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928890061  161 VMFAFDGSEESRRNLERLAMSPLLRGLECHLV----------------------MVNGKEEELLTAQQILRDAGIENSTT 218
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLhvidpppsgaasladesaeeeeLELELAEAEALAAAAAAEAGGVKVEV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 928890061  219 HLTGQSVGDALIRYAEENAVDLIVMGAYGHSRLRQFFIGSHTSEMLQKTQQPLLILR 275
Cdd:pfam00582  81 VVVVGDPAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 5-152 6.45e-14

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 67.05  E-value: 6.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928890061    5 VTACVDGSLSTRSVCEYAAWAARTLQSQLALLHVIEKDSTPVVSDLTGTLGIDSQQLLTDELVEIEgqrnrllmvqgkai 84
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALA-------------- 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 928890061   85 ldscAELLQKQGTPDVLLMQKHGTPDEILTELSDLR---LMVLGRRG----SQHPVGSHLESVIRLQKKPLLVVP 152
Cdd:pfam00582  67 ----AAAAAEAGGVKVEVVVVVGDPAEEILEVAEEEdadLIVMGSRGrsglSRLLLGSVAEYVLRHAPCPVLVVR 137
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 4-151 4.28e-13

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 64.68  E-value: 4.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928890061   4 TVTACVDGSLSTRSVCEYAAWAARTLQSQLALLHVIEKDSTPVVSDLtgtlgidsqqlltdelveiEGQRNRLLMVQGKA 83
Cdd:cd00293    1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSSSLSGG-------------------LEELADELKEEAEE 61

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 928890061  84 ILDSCAELLQKQGtPDVLLMQKHGTP-DEILTELSDLR--LMVLGRRG----SQHPVGSHLESVIRLQKKPLLVV 151
Cdd:cd00293   62 LLEEAKKLAEEAG-VEVETIVVEGDPaEAILEEAKELGadLIVMGSRGrsglKRLLLGSVSEYVLRHAPCPVLVV 135
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
1-151 1.08e-11

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 61.09  E-value: 1.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928890061   1 MNNTVTACVDGSLSTRSVCEYAAWAARTLQSQLALLHVIEKDSTPVvsdltgtlgiDSQQLLTDELVEiegqrnrllmvQ 80
Cdd:COG0589    1 MYKRILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPPSAA----------AGPEELEEELRE-----------E 59

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 928890061  81 GKAILDSCAELLQKQGTpDVLLMQKHGTPDEILTELSDLR---LMVLGRRG----SQHPVGSHLESVIRLQKKPLLVV 151
Cdd:COG0589   60 AEEALEEAAERLEEAGV-EVETVVREGDPAEAILEAAEELdadLIVMGSRGrsglRRLLLGSVAERVLRHAPCPVLVV 136
 
Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
160-273 2.12e-22

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 89.98  E-value: 2.12e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928890061 160 RVMFAFDGSEESRRNLERLAMSPLLRGLECHLVMV-------------------NGKEEELLTAQQILRDAGIENSTTHL 220
Cdd:COG0589    4 RILVPTDGSEEAERALEYAAELAKALGAELHLLHVvdpppsaaagpeeleeelrEEAEEALEEAAERLEEAGVEVETVVR 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 928890061 221 TGqSVGDALIRYAEENAVDLIVMGAYGHSRLRQFFIGSHTSEMLQKTQQPLLI 273
Cdd:COG0589   84 EG-DPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 160-273 3.08e-22

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 89.33  E-value: 3.08e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928890061 160 RVMFAFDGSEESRRNLERLAMSPLLRGLECHLVMV--------------------NGKEEELL-TAQQILRDAGIENSTT 218
Cdd:cd00293    1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVvdpppssslsggleeladelKEEAEELLeEAKKLAEEAGVEVETI 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 928890061 219 HLTGqSVGDALIRYAEENAVDLIVMGAYGHSRLRQFFIGSHTSEMLQKTQQPLLI 273
Cdd:cd00293   81 VVEG-DPAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLV 134
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 161-275 5.36e-16

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 72.83  E-value: 5.36e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928890061  161 VMFAFDGSEESRRNLERLAMSPLLRGLECHLV----------------------MVNGKEEELLTAQQILRDAGIENSTT 218
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLhvidpppsgaasladesaeeeeLELELAEAEALAAAAAAEAGGVKVEV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 928890061  219 HLTGQSVGDALIRYAEENAVDLIVMGAYGHSRLRQFFIGSHTSEMLQKTQQPLLILR 275
Cdd:pfam00582  81 VVVVGDPAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 5-152 6.45e-14

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 67.05  E-value: 6.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928890061    5 VTACVDGSLSTRSVCEYAAWAARTLQSQLALLHVIEKDSTPVVSDLTGTLGIDSQQLLTDELVEIEgqrnrllmvqgkai 84
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALA-------------- 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 928890061   85 ldscAELLQKQGTPDVLLMQKHGTPDEILTELSDLR---LMVLGRRG----SQHPVGSHLESVIRLQKKPLLVVP 152
Cdd:pfam00582  67 ----AAAAAEAGGVKVEVVVVVGDPAEEILEVAEEEdadLIVMGSRGrsglSRLLLGSVAEYVLRHAPCPVLVVR 137
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 4-151 4.28e-13

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 64.68  E-value: 4.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928890061   4 TVTACVDGSLSTRSVCEYAAWAARTLQSQLALLHVIEKDSTPVVSDLtgtlgidsqqlltdelveiEGQRNRLLMVQGKA 83
Cdd:cd00293    1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSSSLSGG-------------------LEELADELKEEAEE 61

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 928890061  84 ILDSCAELLQKQGtPDVLLMQKHGTP-DEILTELSDLR--LMVLGRRG----SQHPVGSHLESVIRLQKKPLLVV 151
Cdd:cd00293   62 LLEEAKKLAEEAG-VEVETIVVEGDPaEAILEEAKELGadLIVMGSRGrsglKRLLLGSVSEYVLRHAPCPVLVV 135
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
1-151 1.08e-11

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 61.09  E-value: 1.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928890061   1 MNNTVTACVDGSLSTRSVCEYAAWAARTLQSQLALLHVIEKDSTPVvsdltgtlgiDSQQLLTDELVEiegqrnrllmvQ 80
Cdd:COG0589    1 MYKRILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPPSAA----------AGPEELEEELRE-----------E 59

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 928890061  81 GKAILDSCAELLQKQGTpDVLLMQKHGTPDEILTELSDLR---LMVLGRRG----SQHPVGSHLESVIRLQKKPLLVV 151
Cdd:COG0589   60 AEEALEEAAERLEEAGV-EVETVVREGDPAEAILEAAEELdadLIVMGSRGrsglRRLLLGSVAERVLRHAPCPVLVV 136
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 160-275 1.75e-07

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 49.54  E-value: 1.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928890061 160 RVMFAFDGSEESRRNLERlAMSPLLR-GLECHLVMV-------------------------NGKEEELL--TAQQILRDA 211
Cdd:cd23659    2 KVLIAVDGSEESEYALEW-ALENLHRpGDEVVLLHVieppslpaaslgsgseewealeeeaREKAEKLLekYEKKLKEEK 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 928890061 212 GIeNSTTHLTGQSVGDALIRYAEENAVDLIVMGAYGHSRLRQFFIGSHTSEMLQKTQQPLLILR 275
Cdd:cd23659   81 GI-KVKVEVVAGDPGEVICKAAEELKADLIVMGSRGLGALKRTLLGSVSDYVVHHSPCPVLVVR 143
USP-E_repeat2 cd23660
Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP ...
 192-275 3.00e-05

Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467506  Cd Length: 148  Bit Score: 43.03  E-value: 3.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928890061 192 VMVNGKEEELLTAQQILRDA-GIENSTTHLTGQSVGDALIRYAEENAVDLIVMGAYGHSRLRQFFIGSHTSEMLQKTQQP 270
Cdd:cd23660   63 EYVDAIRGRHLEAMKALRQKfGIDEEQTHVLEGLPEEVIPDFAEELDADIVVLGTVARTGLSGALIGNTAEHVLDHLNCD 142


                 ....*
gi 928890061 271 LLILR 275
Cdd:cd23660  143 LLALK 147
USP-A-like cd23657
universal stress protein A and similar proteins; The universal stress protein UspA is a small ...
 159-275 9.20e-04

universal stress protein A and similar proteins; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced several-fold when cellular viability is challenged with heat shock, nutrient starvation, stress agents which arrest cell growth, or DNA-damaging agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, suggesting that it asserts a general "stress endurance" activity. In general, these proteins form dimers and have domains for nucleotide binding activity. The crystal structure of Haemophilus influenzae UspA reveals an asymmetric dimer with a tertiary alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, but unlike MJ0577, it lacks ATP-binding activity.


Pssm-ID: 467504  Cd Length: 138  Bit Score: 38.44  E-value: 9.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928890061 159 SRVMFAFDGSEESRRNLERLAMSPLLRGLECHLVMVNGKEEELLTA-------------QQILRDA--------GIENST 217
Cdd:cd23657    2 KHILVAVDLSPESQSLVDKAVEIARENDAKLSLIHVDEDISEYYTGlidvdiaalqdleSTMLEEAlknlselaGYPVDH 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 928890061 218 THLTGQSVGDALIRYAEENAVDLIVMGAYGHSRLRQffIGSHTSEMLQKTQQPLLILR 275
Cdd:cd23657   82 TFIGYGDLKEEILEVAKKHNVDLIVCGHHGDFGLSL--LGSSARAVLNSAPCDVLIVP 137
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 8-128 3.08e-03

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 37.21  E-value: 3.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928890061   8 CVDGSlstrSVCEYA-AWAARTL---QSQLALLHVIEKDSTPVVSDLTGTLGIDSQQLLTDELVEiegqrnrllmvqgkA 83
Cdd:cd23659    6 AVDGS----EESEYAlEWALENLhrpGDEVVLLHVIEPPSLPAASLGSGSEEWEALEEEAREKAE--------------K 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 928890061  84 ILDSCAELLQKQGTPDVLLMQKHGTPDEILTELSD---LRLMVLGRRG 128
Cdd:cd23659   68 LLEKYEKKLKEEKGIKVKVEVVAGDPGEVICKAAEelkADLIVMGSRG 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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