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Conserved domains on  [gi|931603855|ref|WP_054294608|]
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cupin [Kibdelosporangium phytohabitans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EutQ COG4766
Ethanolamine utilization protein EutQ, cupin superfamily (function unknown) [Amino acid ...
 20-110 1.65e-31

Ethanolamine utilization protein EutQ, cupin superfamily (function unknown) [Amino acid transport and metabolism];


:

Pssm-ID: 443798  Cd Length: 123  Bit Score: 108.15  E-value: 1.65e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 931603855  20 DQQVFLGDVVDQTSGAEMSVGFGRYGKGeRNPWKVTYDEALIVTKGSFTVEGPEGPVTAGVGEVIYLRADTEVLYVANEE 99
Cdd:COG4766   32 GDKVYLKDVVTLEESSRMGAGFMRLEKT-TFPWTLTYDEVDYVLEGTLTIEIDGETVTAGPGDVIYIPKGSSITFSTPEK 110

                         90
                 ....*....|.
gi 931603855 100 TELVYVTYPHW 110
Cdd:COG4766  111 ARFFYVTYPAN 121
 
Name Accession Description Interval E-value
EutQ COG4766
Ethanolamine utilization protein EutQ, cupin superfamily (function unknown) [Amino acid ...
 20-110 1.65e-31

Ethanolamine utilization protein EutQ, cupin superfamily (function unknown) [Amino acid transport and metabolism];


Pssm-ID: 443798  Cd Length: 123  Bit Score: 108.15  E-value: 1.65e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 931603855  20 DQQVFLGDVVDQTSGAEMSVGFGRYGKGeRNPWKVTYDEALIVTKGSFTVEGPEGPVTAGVGEVIYLRADTEVLYVANEE 99
Cdd:COG4766   32 GDKVYLKDVVTLEESSRMGAGFMRLEKT-TFPWTLTYDEVDYVLEGTLTIEIDGETVTAGPGDVIYIPKGSSITFSTPEK 110

                         90
                 ....*....|.
gi 931603855 100 TELVYVTYPHW 110
Cdd:COG4766  111 ARFFYVTYPAN 121
cupin_EutQ cd02228
Clostridium difficile EutQ and related proteins, cupin domain; This family includes bacterial ...
 23-107 1.35e-12

Clostridium difficile EutQ and related proteins, cupin domain; This family includes bacterial and fungal proteins homologous to ethanolamine utilization protein EutQ found in Clostridium difficile, as well as in other bacteria, including the enteric pathogens Salmonella enterica and Enterococcus faecalis. EutQ is encoded by the eutQ gene which is part of the eut (ethanolamine utilization) operon found to be essential during anoxic growth of S. enterica on ethanolamine and tetrathionate. In C. difficile, inability to utilize ethanolamine results in greater virulence and a shorter time to morbidity in the animal model, suggesting that, in contrast to other intestinal pathogens, the metabolism of ethanolamine can delay the onset of disease. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization. In contrast to the metal-binding catalytic cupins, the EutQ family does not possess the histidine residues that are responsible for metal coordination in the oxidoreductase and epimerase classes of cupins.


Pssm-ID: 380357 [Multi-domain]  Cd Length: 84  Bit Score: 58.67  E-value: 1.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 931603855  23 VFLGDVVDQTSGAEMSVGFGRYGKGErNPWKVTYDEALIVTKGSFTVEGPEGPVTAGVGEVIYLRADTEVLYVANEETEL 102
Cdd:cd02228    1 VFLKDVVTSEEGSPMSAGFMELEKKS-FPWTLTYDEIKYVLEGELEITDDGQTVTAKPGDVLFIPKGSKITFSTPDYAKF 79


                 ....*
gi 931603855 103 VYVTY 107
Cdd:cd02228   80 FYVTY 84
EutQ pfam06249
Ethanolamine utilization protein EutQ; The eut operon of Salmonella typhimurium encodes ...
 16-108 8.46e-05

Ethanolamine utilization protein EutQ; The eut operon of Salmonella typhimurium encodes proteins involved in the cobalamin-dependent degradation of ethanolamine. The role of EutQ in this process is unclear.


Pssm-ID: 114941  Cd Length: 152  Bit Score: 39.86  E-value: 8.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 931603855   16 FQRLD-----QQVFLGDVVDQTSGAEMSVGFGRYgKGERNPWKVTYDEALIVTKGSFTVEGPEGPVTAGVGEVIYLRADT 90
Cdd:pfam06249  51 FGRLDtgnphDVVYTKDLVTLEESPRLGAGLMEM-KETTFPWTLNYDEIDYVIEGRLDVRIDGRTVSAKAGDVIFIPKGS 129

                          90
                  ....*....|....*...
gi 931603855   91 EVLYVANEETELVYVTYP 108
Cdd:pfam06249 130 KIEFSVTSYAKFLYVTYP 147
PRK15457 PRK15457
ethanolamine utilization acetate kinase EutQ;
23-108 1.29e-03

ethanolamine utilization acetate kinase EutQ;


Pssm-ID: 185354 [Multi-domain]  Cd Length: 233  Bit Score: 36.84  E-value: 1.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 931603855  23 VFLGDVVDQTSGAEMSVGFGRYgKGERNPWKVTYDEALIVTKGSFTVEGPEGPVTAGVGEVIYLRADTEVLYVANEETEL 102
Cdd:PRK15457 143 VGLTDLVTGDDGSSMAAGFMQW-ENAFFPWTLNYDEIDMVLEGELHVRHEGETMIAKAGDVMFIPKGSSIEFGTPSSVRF 221


                 ....*.
gi 931603855 103 VYVTYP 108
Cdd:PRK15457 222 LYVAWP 227
 
Name Accession Description Interval E-value
EutQ COG4766
Ethanolamine utilization protein EutQ, cupin superfamily (function unknown) [Amino acid ...
 20-110 1.65e-31

Ethanolamine utilization protein EutQ, cupin superfamily (function unknown) [Amino acid transport and metabolism];


Pssm-ID: 443798  Cd Length: 123  Bit Score: 108.15  E-value: 1.65e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 931603855  20 DQQVFLGDVVDQTSGAEMSVGFGRYGKGeRNPWKVTYDEALIVTKGSFTVEGPEGPVTAGVGEVIYLRADTEVLYVANEE 99
Cdd:COG4766   32 GDKVYLKDVVTLEESSRMGAGFMRLEKT-TFPWTLTYDEVDYVLEGTLTIEIDGETVTAGPGDVIYIPKGSSITFSTPEK 110

                         90
                 ....*....|.
gi 931603855 100 TELVYVTYPHW 110
Cdd:COG4766  111 ARFFYVTYPAN 121
cupin_EutQ cd02228
Clostridium difficile EutQ and related proteins, cupin domain; This family includes bacterial ...
 23-107 1.35e-12

Clostridium difficile EutQ and related proteins, cupin domain; This family includes bacterial and fungal proteins homologous to ethanolamine utilization protein EutQ found in Clostridium difficile, as well as in other bacteria, including the enteric pathogens Salmonella enterica and Enterococcus faecalis. EutQ is encoded by the eutQ gene which is part of the eut (ethanolamine utilization) operon found to be essential during anoxic growth of S. enterica on ethanolamine and tetrathionate. In C. difficile, inability to utilize ethanolamine results in greater virulence and a shorter time to morbidity in the animal model, suggesting that, in contrast to other intestinal pathogens, the metabolism of ethanolamine can delay the onset of disease. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization. In contrast to the metal-binding catalytic cupins, the EutQ family does not possess the histidine residues that are responsible for metal coordination in the oxidoreductase and epimerase classes of cupins.


Pssm-ID: 380357 [Multi-domain]  Cd Length: 84  Bit Score: 58.67  E-value: 1.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 931603855  23 VFLGDVVDQTSGAEMSVGFGRYGKGErNPWKVTYDEALIVTKGSFTVEGPEGPVTAGVGEVIYLRADTEVLYVANEETEL 102
Cdd:cd02228    1 VFLKDVVTSEEGSPMSAGFMELEKKS-FPWTLTYDEIKYVLEGELEITDDGQTVTAKPGDVLFIPKGSKITFSTPDYAKF 79


                 ....*
gi 931603855 103 VYVTY 107
Cdd:cd02228   80 FYVTY 84
EutQ pfam06249
Ethanolamine utilization protein EutQ; The eut operon of Salmonella typhimurium encodes ...
 16-108 8.46e-05

Ethanolamine utilization protein EutQ; The eut operon of Salmonella typhimurium encodes proteins involved in the cobalamin-dependent degradation of ethanolamine. The role of EutQ in this process is unclear.


Pssm-ID: 114941  Cd Length: 152  Bit Score: 39.86  E-value: 8.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 931603855   16 FQRLD-----QQVFLGDVVDQTSGAEMSVGFGRYgKGERNPWKVTYDEALIVTKGSFTVEGPEGPVTAGVGEVIYLRADT 90
Cdd:pfam06249  51 FGRLDtgnphDVVYTKDLVTLEESPRLGAGLMEM-KETTFPWTLNYDEIDYVIEGRLDVRIDGRTVSAKAGDVIFIPKGS 129

                          90
                  ....*....|....*...
gi 931603855   91 EVLYVANEETELVYVTYP 108
Cdd:pfam06249 130 KIEFSVTSYAKFLYVTYP 147
PRK15457 PRK15457
ethanolamine utilization acetate kinase EutQ;
23-108 1.29e-03

ethanolamine utilization acetate kinase EutQ;


Pssm-ID: 185354 [Multi-domain]  Cd Length: 233  Bit Score: 36.84  E-value: 1.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 931603855  23 VFLGDVVDQTSGAEMSVGFGRYgKGERNPWKVTYDEALIVTKGSFTVEGPEGPVTAGVGEVIYLRADTEVLYVANEETEL 102
Cdd:PRK15457 143 VGLTDLVTGDDGSSMAAGFMQW-ENAFFPWTLNYDEIDMVLEGELHVRHEGETMIAKAGDVMFIPKGSSIEFGTPSSVRF 221


                 ....*.
gi 931603855 103 VYVTYP 108
Cdd:PRK15457 222 LYVAWP 227
ManC COG0662
Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];
29-115 9.59e-03

Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 440426 [Multi-domain]  Cd Length: 114  Bit Score: 33.58  E-value: 9.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 931603855  29 VDQTSGAEMSVGFGRYGKGERNPWKVTY--DEALIVTKGSFTVEGPEGPVTAGVGEVIYLRADTEVLYVANEETELVY-- 104
Cdd:COG0662   19 VLGEGGERLSVKRITVPPGAELSLHVHPhrDEFFYVLEGTGEVTIGDEEVELKAGDSVYIPAGVPHRLRNPGDEPLELle 98

                         90
                 ....*....|.
gi 931603855 105 VTYPHWLRATE 115
Cdd:COG0662   99 VQAPAYLGEDD 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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