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Conserved domains on  [gi|935564642|ref|WP_054449784|]
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magnesium transporter CorA family protein [Apilactobacillus kunkeei]

Protein Classification

magnesium transporter CorA family protein( domain architecture ID 10191291)

magnesium transporter CorA family protein belonging to the CorA metal ion transporter (MIT) superfamily, similar to CorA which mediates both influx and efflux of magnesium, and may also transport nickel and cobalt

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
EcCorA_ZntB-like_u2 cd12827
uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB ...
12-294 1.00e-69

uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; A uncharacterized subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB (EcCorA-ZntB_like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes.The EcCorA-ZntB-like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA-ZntB-like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


:

Pssm-ID: 213361 [Multi-domain]  Cd Length: 289  Bit Score: 217.76  E-value: 1.00e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642  12 WVEMVDANTKEVVETIDKYKLPNILKGYMLDAHEHSRFEYDPVKKYSVMIMRALISGQDENVQ--TSPVVIAFTNDLIIT 89
Cdd:cd12827    1 WINVVNPTEEEIEQLAEKYGIPEDFLTYALDEEERSRIEYDDDTDYLLIILDVPVEEEEDDDEyeTIPLGIILTKDRLIT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642  90 KSDS---------RYRIKQETRCNKFDMVFNMLQRINKPYMNKLDQINESVENLQNKRSKnSVNNHHLNEIAILKNDLVY 160
Cdd:cd12827   81 ICNHetdllddflEGRVKNFDTSSKTRFLLQILYRIATSYLKYLRQINKERDELEQELRK-STKNKELFQLLDLEKSLVY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642 161 LKTATAANIMSINQLQKSSdnfeiPISFNQRQDQHIDDVAVEYEESKYMFDVLDEIVSQIEDTYSNIINNNLNDVMKVLT 240
Cdd:cd12827  160 FSTSLKSNEIVLEKLKRSR-----SLKLDEEDKELLEDVIIENKQAIEMAEIYSDILSGLMDAFASVISNNLNNVMKFLT 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 935564642 241 VWSLILAIPPIISGFYGMNVNvLPFANSSWSWFFTLVITVAIIYWMIYYLKKHH 294
Cdd:cd12827  235 SITIVLTIPTIITGFYGMNVP-LPFADSPYAFWIILLISLLLSVIVALILRRKK 287
 
Name Accession Description Interval E-value
EcCorA_ZntB-like_u2 cd12827
uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB ...
12-294 1.00e-69

uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; A uncharacterized subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB (EcCorA-ZntB_like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes.The EcCorA-ZntB-like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA-ZntB-like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213361 [Multi-domain]  Cd Length: 289  Bit Score: 217.76  E-value: 1.00e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642  12 WVEMVDANTKEVVETIDKYKLPNILKGYMLDAHEHSRFEYDPVKKYSVMIMRALISGQDENVQ--TSPVVIAFTNDLIIT 89
Cdd:cd12827    1 WINVVNPTEEEIEQLAEKYGIPEDFLTYALDEEERSRIEYDDDTDYLLIILDVPVEEEEDDDEyeTIPLGIILTKDRLIT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642  90 KSDS---------RYRIKQETRCNKFDMVFNMLQRINKPYMNKLDQINESVENLQNKRSKnSVNNHHLNEIAILKNDLVY 160
Cdd:cd12827   81 ICNHetdllddflEGRVKNFDTSSKTRFLLQILYRIATSYLKYLRQINKERDELEQELRK-STKNKELFQLLDLEKSLVY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642 161 LKTATAANIMSINQLQKSSdnfeiPISFNQRQDQHIDDVAVEYEESKYMFDVLDEIVSQIEDTYSNIINNNLNDVMKVLT 240
Cdd:cd12827  160 FSTSLKSNEIVLEKLKRSR-----SLKLDEEDKELLEDVIIENKQAIEMAEIYSDILSGLMDAFASVISNNLNNVMKFLT 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 935564642 241 VWSLILAIPPIISGFYGMNVNvLPFANSSWSWFFTLVITVAIIYWMIYYLKKHH 294
Cdd:cd12827  235 SITIVLTIPTIITGFYGMNVP-LPFADSPYAFWIILLISLLLSVIVALILRRKK 287
CorA COG0598
Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];
11-292 2.87e-45

Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];


Pssm-ID: 440363 [Multi-domain]  Cd Length: 305  Bit Score: 154.99  E-value: 2.87e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642  11 TWVEMVDANTKEVVETIDKYKLPNILKGYMLDAHEHSRFEYDPvkKYSVMIMRALI-SGQDENVQTSPVVIAFTNDLIIT 89
Cdd:COG0598   16 VWIDLDGPTDEELEWLAEEFGLHPLALEDALDIEQRPKLEEYD--DYLFIVLRTLNyNEEEEELETGPLSIFLGPNFLIT 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642  90 ----KSDS----RYRIKQETRCNKF---DMVFNMLQRINKPYMNKLDQINESVENLQnKRSKNSVNNHHLNEIAILKNDL 158
Cdd:COG0598   94 vrerPLDAfddvRERLERGPGLLPRgpdYLLYALLDAIVDRYFPVLEELEDELDELE-DELFESPDNELLRRLYRLRREL 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642 159 VYLKTATAANIMSINQLQKSSdnfeiPISFNQRQDQHIDDVAVEYEESKYMFDVLDEIVSQIEDTYSNIINNNLNDVMKV 238
Cdd:COG0598  173 VRLRRALAPLREVLSRLLRGE-----SPLISEEDREYLRDVYDHLERLLEMVDSLRERLSGLLDAYLSLISNRQNEIMKV 247
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 935564642 239 LTVWSLILAIPPIISGFYGMNVNVLPFANSSWSWFFTLVITVAIIYWMIYYLKK 292
Cdd:COG0598  248 LTIIAAIFLPPTFIAGIYGMNFEGMPELDWPYGYPIVLGLMLLIAVLLYLYFKR 301
CorA pfam01544
CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx ...
11-292 1.97e-38

CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx system of Salmonella typhimurium and Escherichia coli. CorA is virtually ubiquitous in the Bacteria and Archaea. There are also eukaryotic relatives of this protein. The family includes the MRS2 protein from yeast that is thought to be an RNA splicing protein. However its membership of this family suggests that its effect on splicing is due to altered magnesium levels in the cell.


Pssm-ID: 460246 [Multi-domain]  Cd Length: 292  Bit Score: 137.06  E-value: 1.97e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642   11 TWVEmVDANTKEVVETI-DKYKLPNILKGYMLDAHEHSRFEYDpvKKYSVMIMRAL-ISGQDENVQTSPVVIAFTNDLII 88
Cdd:pfam01544   5 VWLD-LDSPTEAELEWLaRTLGLDPLALEDLLDPEERPRVEDY--DDYFLLVLPGVnLDDSEEADELVTVSILLGDNFLI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642   89 TKSD----------SRYRIKQETRCNKFDMVFNMLQRINKPYMNKLDQINESVENLQnKRSKNSVNNHHLNEIAILKNDL 158
Cdd:pfam01544  82 TVRHeplpaldevrKRLTLLGGGPLDPGDLLYRLLDEIVDRFLELLEKLEDELDELE-DELEDETNNELLRELAALRRSL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642  159 VYLKTATAANIMSINQLQKSSDNFEIpisfNQRQDQHIDDVAVEYEESKYMFDVLDEIVSQIEDTYSNIINNNLNDVMKV 238
Cdd:pfam01544 161 VYLRRSLLPQRDVLNRLLRREDDPLL----DDEQKEYLRDLLDRLERLLEDLDALRERLRSLQDEYSSLLSERTNRVMKV 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 935564642  239 LTVWSLILAIPPIISGFYGMNVNVLPFANSSWSWFF--TLVITVAIIYWMIYYLKK 292
Cdd:pfam01544 237 LTVVTAIFLPLTLITGIYGMNFGGLPELEWSYGYPFvlILGLMILLAILLLFYFRR 292
corA TIGR00383
magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp ...
12-292 1.07e-15

magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp Genomics 1998;3(3):151-69 discusses this family and suggests that some members may have functions other than Mg2+ transport. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273048 [Multi-domain]  Cd Length: 318  Bit Score: 75.89  E-value: 1.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642   12 WVEMVDANTKEVVetidkYKLPNILKGYMLDAH----EHSRFEYDPVKKYSVMIMRALISGQDENVQTSPVVIAFTNDLI 87
Cdd:TIGR00383  29 WIDLIEPTDEERL-----AKLGQFFAIHPLALEdilnSPQRPKVEEDEDHLFIISFFLNEDEDDTFETEQVSFILGKNLL 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642   88 ITKSD----------SRYRIKQETR-CNKFDMVFNMLQRINKPYMNKLDQINESVENLQNKRSKNSvNNHHLNEIAILKN 156
Cdd:TIGR00383 104 FTIHErelpafdsirERIRTSQKVFeKGADYLLYDIFDAIIDSYFPLLENIEDELEELEDEIISGP-TSTLMDEILSLRT 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642  157 DLVYLKTATAANIMSINQLQKSSDNFEIpisfnQRQDQHI-DDVAVEYEESKYMFDVLDEIVSQIEDTYSNIINNNLNDV 235
Cdd:TIGR00383 183 ELLALRRSLWPLRDVLNFLLRKTHLPIQ-----TEEVREYlRDIYDHILSLLEMIETYRELLSSLMDLYLSLVNNKMNEI 257
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 935564642  236 MKVLTVWSLILAIPPIISGFYGMNVNVLPFANSSWSWFFTLVITVAIIYWMIYYLKK 292
Cdd:TIGR00383 258 MKILTVVSTIFIPLTFIAGIYGMNFKFMPELNWKYGYPAVLIVMAVIALGPLIYFRR 314
 
Name Accession Description Interval E-value
EcCorA_ZntB-like_u2 cd12827
uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB ...
12-294 1.00e-69

uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; A uncharacterized subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB (EcCorA-ZntB_like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes.The EcCorA-ZntB-like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA-ZntB-like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213361 [Multi-domain]  Cd Length: 289  Bit Score: 217.76  E-value: 1.00e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642  12 WVEMVDANTKEVVETIDKYKLPNILKGYMLDAHEHSRFEYDPVKKYSVMIMRALISGQDENVQ--TSPVVIAFTNDLIIT 89
Cdd:cd12827    1 WINVVNPTEEEIEQLAEKYGIPEDFLTYALDEEERSRIEYDDDTDYLLIILDVPVEEEEDDDEyeTIPLGIILTKDRLIT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642  90 KSDS---------RYRIKQETRCNKFDMVFNMLQRINKPYMNKLDQINESVENLQNKRSKnSVNNHHLNEIAILKNDLVY 160
Cdd:cd12827   81 ICNHetdllddflEGRVKNFDTSSKTRFLLQILYRIATSYLKYLRQINKERDELEQELRK-STKNKELFQLLDLEKSLVY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642 161 LKTATAANIMSINQLQKSSdnfeiPISFNQRQDQHIDDVAVEYEESKYMFDVLDEIVSQIEDTYSNIINNNLNDVMKVLT 240
Cdd:cd12827  160 FSTSLKSNEIVLEKLKRSR-----SLKLDEEDKELLEDVIIENKQAIEMAEIYSDILSGLMDAFASVISNNLNNVMKFLT 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 935564642 241 VWSLILAIPPIISGFYGMNVNvLPFANSSWSWFFTLVITVAIIYWMIYYLKKHH 294
Cdd:cd12827  235 SITIVLTIPTIITGFYGMNVP-LPFADSPYAFWIILLISLLLSVIVALILRRKK 287
CorA COG0598
Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];
11-292 2.87e-45

Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];


Pssm-ID: 440363 [Multi-domain]  Cd Length: 305  Bit Score: 154.99  E-value: 2.87e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642  11 TWVEMVDANTKEVVETIDKYKLPNILKGYMLDAHEHSRFEYDPvkKYSVMIMRALI-SGQDENVQTSPVVIAFTNDLIIT 89
Cdd:COG0598   16 VWIDLDGPTDEELEWLAEEFGLHPLALEDALDIEQRPKLEEYD--DYLFIVLRTLNyNEEEEELETGPLSIFLGPNFLIT 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642  90 ----KSDS----RYRIKQETRCNKF---DMVFNMLQRINKPYMNKLDQINESVENLQnKRSKNSVNNHHLNEIAILKNDL 158
Cdd:COG0598   94 vrerPLDAfddvRERLERGPGLLPRgpdYLLYALLDAIVDRYFPVLEELEDELDELE-DELFESPDNELLRRLYRLRREL 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642 159 VYLKTATAANIMSINQLQKSSdnfeiPISFNQRQDQHIDDVAVEYEESKYMFDVLDEIVSQIEDTYSNIINNNLNDVMKV 238
Cdd:COG0598  173 VRLRRALAPLREVLSRLLRGE-----SPLISEEDREYLRDVYDHLERLLEMVDSLRERLSGLLDAYLSLISNRQNEIMKV 247
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 935564642 239 LTVWSLILAIPPIISGFYGMNVNVLPFANSSWSWFFTLVITVAIIYWMIYYLKK 292
Cdd:COG0598  248 LTIIAAIFLPPTFIAGIYGMNFEGMPELDWPYGYPIVLGLMLLIAVLLYLYFKR 301
CorA pfam01544
CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx ...
11-292 1.97e-38

CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx system of Salmonella typhimurium and Escherichia coli. CorA is virtually ubiquitous in the Bacteria and Archaea. There are also eukaryotic relatives of this protein. The family includes the MRS2 protein from yeast that is thought to be an RNA splicing protein. However its membership of this family suggests that its effect on splicing is due to altered magnesium levels in the cell.


Pssm-ID: 460246 [Multi-domain]  Cd Length: 292  Bit Score: 137.06  E-value: 1.97e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642   11 TWVEmVDANTKEVVETI-DKYKLPNILKGYMLDAHEHSRFEYDpvKKYSVMIMRAL-ISGQDENVQTSPVVIAFTNDLII 88
Cdd:pfam01544   5 VWLD-LDSPTEAELEWLaRTLGLDPLALEDLLDPEERPRVEDY--DDYFLLVLPGVnLDDSEEADELVTVSILLGDNFLI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642   89 TKSD----------SRYRIKQETRCNKFDMVFNMLQRINKPYMNKLDQINESVENLQnKRSKNSVNNHHLNEIAILKNDL 158
Cdd:pfam01544  82 TVRHeplpaldevrKRLTLLGGGPLDPGDLLYRLLDEIVDRFLELLEKLEDELDELE-DELEDETNNELLRELAALRRSL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642  159 VYLKTATAANIMSINQLQKSSDNFEIpisfNQRQDQHIDDVAVEYEESKYMFDVLDEIVSQIEDTYSNIINNNLNDVMKV 238
Cdd:pfam01544 161 VYLRRSLLPQRDVLNRLLRREDDPLL----DDEQKEYLRDLLDRLERLLEDLDALRERLRSLQDEYSSLLSERTNRVMKV 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 935564642  239 LTVWSLILAIPPIISGFYGMNVNVLPFANSSWSWFF--TLVITVAIIYWMIYYLKK 292
Cdd:pfam01544 237 LTVVTAIFLPLTLITGIYGMNFGGLPELEWSYGYPFvlILGLMILLAILLLFYFRR 292
TmCorA-like cd12822
Thermotoga maritima CorA-like family; This family belongs to the MIT superfamily of essential ...
41-292 8.43e-29

Thermotoga maritima CorA-like family; This family belongs to the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the Thermotoga maritima CorA_like family are found in all three kingdoms of life. It is a functionally diverse family, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes three Saccharomyces cerevisiae members: two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213356 [Multi-domain]  Cd Length: 289  Bit Score: 111.51  E-value: 8.43e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642  41 LDAHEHSRFE-YDpvkKYSVMIMRALISGQDEN-VQTSPVVIAFTNDLIIT--KSDSRYRIKQETRCNKF---------D 107
Cdd:cd12822   30 LNERQRPKIEeYD---DYLFLVLRALRYDEEELeLETSELSIFLGKNFLVTvhEGPLRLIDEVIERLLSDpkllpkgpdF 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642 108 MVFNMLQRINKPYMNKLDQINESVENLQNKRSKNSvNNHHLNEIAILKNDLVYLKTATAANIMSINQLQKSSDNF---EI 184
Cdd:cd12822  107 LLYAILDAIVDSYFPILDELEDRLDELEDEILEEP-RREVLRELFALRRELLRLRRILSPQREVLNRLLRRENELiseEL 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642 185 PISFNQRQDqHIDDVAVeyeeskyMFDVLDEIVSQIEDTYSNIINNNLNDVMKVLTVWSLILAIPPIISGFYGMNVNVLP 264
Cdd:cd12822  186 RPYFRDVYD-HLERLAE-------LLDSYRDLLSSLLDAYLSLQSNRTNEVMKVLTIITTIFLPLTFITGIYGMNFEYMP 257
                        250       260
                 ....*....|....*....|....*...
gi 935564642 265 FANSSWSWFFTLVITVAIIYWMIYYLKK 292
Cdd:cd12822  258 ELHWPYGYFIVLGIMLLIAGGLLWWFRR 285
TmCorA-like_1 cd12828
Thermotoga maritima CorA_like subfamily; This subfamily belongs to the Thermotoga maritima ...
11-292 1.69e-19

Thermotoga maritima CorA_like subfamily; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this subfamily are found in all three kingdoms of life. It is functionally diverse subfamily, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes Methanosarcina mazei CorA which may be involved in transport of copper and/or other divalent metal ions. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213362 [Multi-domain]  Cd Length: 294  Bit Score: 86.33  E-value: 1.69e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642  11 TWVEMVDANTKEVVETI-DKYKLPNILKGYMLDAHEHSRFE-YDpvkKYSVMIMRAL-ISGQDENVQTSPVVIAFTNDLI 87
Cdd:cd12828    3 TWINVDGLHDIELIEKLgERFGLHPLVLEDILNTGQRPKVEeYD---DYLFIVLKMLyYDEDTGELESEQVSLILGKNYV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642  88 ITKsdsryrikQETRCNKFDMVfnmLQRINKP-----------------------YMNKLDQINESVENLQNkRSKNSVN 144
Cdd:cd12828   80 ISF--------QERPGDVFDPV---RERLRNGkgrirkkgadylayalldaivdnYFPVLEKLGDRIEDLEE-ELLENPT 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642 145 NHHLNEIAILKNDLVYLKTAtaanIM----SINQLQKSSDNFeipisfnqrqdqhIDDvaveyEESKYMFDVLDEIVSQI 220
Cdd:cd12828  148 PETLERIHKLKRELLFLRRS----IWplreVINRLLRGESPL-------------ISE-----ETRPYLRDVYDHTIQVI 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642 221 E-------------DTYSNIINNNLNDVMKVLTVWSLILaIPP-IISGFYGMNVNVLPFANSSWSWFFTLVITVAIIYWM 286
Cdd:cd12828  206 DtietyrdmlsgllDLYLSSVSNRMNEVMKVLTIISTIF-IPLtFIAGIYGMNFEYMPELEWKYGYPAVLGVMLLIALGM 284

                 ....*.
gi 935564642 287 IYYLKK 292
Cdd:cd12828  285 LLYFKR 290
EcCorA_ZntB-like cd12821
Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily ...
78-292 1.29e-16

Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this family are found in all three kingdoms of life. It is a functionally diverse family, including the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), and the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). It also includes two Saccharomyces cerevisiae members: the inner membrane Mg2+ transporters Mfm1p/Lpe10p, and Mrs2p, and a family of Arabidopsis thaliana members (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213355 [Multi-domain]  Cd Length: 285  Bit Score: 78.13  E-value: 1.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642  78 VVIAFTNDLIITKSDSRYRIKQETRC-NKFDMVFNMLQRINKPYMNKLDQINESVENLQNKrSKNSVNNHHLNEIAILKN 156
Cdd:cd12821   73 ITVRLDELPALDELRQDLRSGQMKSAkSAAELLFVLLGAIIKALLTGIDQFEEKLEELEWD-LLEGNNAIKLDRILELRR 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642 157 DLVYLKTATAANIMSINQLQKSsdnfEIPISFNQRQDQHiDDVAVEYEESKYMFDVLDEIVSQIEDTYSNIINNNLNDVM 236
Cdd:cd12821  152 ELLRLTNLIEPQQEVLMALQEA----FAELLFSEDEEEL-RRTLDRIERLLQLIEEYEQELDTLQDIEEVVSSHRGNEIM 226
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 935564642 237 KVLTVWSLILAIPPIISGFYGMNVNVLPFANSSWSWFFTLVITVAIIYWMIYYLKK 292
Cdd:cd12821  227 KTLTVVTTVFLPLTLIGGLWGMNFKNMPELEWKYGYLFVLGLIILSTAGLYLYLRR 282
corA TIGR00383
magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp ...
12-292 1.07e-15

magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp Genomics 1998;3(3):151-69 discusses this family and suggests that some members may have functions other than Mg2+ transport. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273048 [Multi-domain]  Cd Length: 318  Bit Score: 75.89  E-value: 1.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642   12 WVEMVDANTKEVVetidkYKLPNILKGYMLDAH----EHSRFEYDPVKKYSVMIMRALISGQDENVQTSPVVIAFTNDLI 87
Cdd:TIGR00383  29 WIDLIEPTDEERL-----AKLGQFFAIHPLALEdilnSPQRPKVEEDEDHLFIISFFLNEDEDDTFETEQVSFILGKNLL 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642   88 ITKSD----------SRYRIKQETR-CNKFDMVFNMLQRINKPYMNKLDQINESVENLQNKRSKNSvNNHHLNEIAILKN 156
Cdd:TIGR00383 104 FTIHErelpafdsirERIRTSQKVFeKGADYLLYDIFDAIIDSYFPLLENIEDELEELEDEIISGP-TSTLMDEILSLRT 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642  157 DLVYLKTATAANIMSINQLQKSSDNFEIpisfnQRQDQHI-DDVAVEYEESKYMFDVLDEIVSQIEDTYSNIINNNLNDV 235
Cdd:TIGR00383 183 ELLALRRSLWPLRDVLNFLLRKTHLPIQ-----TEEVREYlRDIYDHILSLLEMIETYRELLSSLMDLYLSLVNNKMNEI 257
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 935564642  236 MKVLTVWSLILAIPPIISGFYGMNVNVLPFANSSWSWFFTLVITVAIIYWMIYYLKK 292
Cdd:TIGR00383 258 MKILTVVSTIFIPLTFIAGIYGMNFKFMPELNWKYGYPAVLIVMAVIALGPLIYFRR 314
MtCorA-like cd12830
Mycobacterium tuberculosis CorA-like subfamily; This bacterial subfamily belongs to the ...
208-292 3.01e-10

Mycobacterium tuberculosis CorA-like subfamily; This bacterial subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporter Mycobacterium tuberculosis CorA (which also transports Co2+). Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213364 [Multi-domain]  Cd Length: 292  Bit Score: 59.84  E-value: 3.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642 208 YMFDVLD---EIVSQIE---DTYSNIINNNL-------NDVMKVLTVWSLILAIPPIISGFYGMNVNVLPFANSSWSWFF 274
Cdd:cd12830  191 YFRDVADhllRVADRVDslrELLSSALQANLalvsvqqNEDMRKISAWAAILAVPTAIAGIYGMNFDHMPELHWTYGYPL 270
                         90
                 ....*....|....*...
gi 935564642 275 TLVITVAIIYWMIYYLKK 292
Cdd:cd12830  271 VLGLMVAVCLGLYRRFRR 288
TmCorA-like_u2 cd12831
Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; This ...
106-292 1.67e-08

Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the TmCorA-like family are found in all three kingdoms of life. It is a functionally diverse family which includes the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and three Saccharomyces cerevisiae proteins: two located in the plasma membrane: the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213365 [Multi-domain]  Cd Length: 287  Bit Score: 54.48  E-value: 1.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642 106 FDMVFNMLQRINKPYMNKLDQINESVENLQNKrSKNSVNNHHLNEIAILKNDLVYLKTAtaanIMSINQLQ---KSSDNF 182
Cdd:cd12831  103 LYIAYMIIDKIVDDYFPIVYEIEDRLNEIEDN-NVDSSNKKLMDEVFDIRSDLLKLRRT----ILPMRDLLyriLNSERL 177
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642 183 EIpisfNQRQDQHIDDVaveYEESKYMFDVLD---EIVSQIEDTYSNIINNNLNDVMKVLTVWSLILAIPPIISGFYGMN 259
Cdd:cd12831  178 EG----DKEQRAYFQDI---YDHLLKLSEMLEsnrEMTADIRDNYESYNSNRMNSIMMTLTIISTIFMPLTFIAGIYGMN 250
                        170       180       190
                 ....*....|....*....|....*....|...
gi 935564642 260 VNVLPFANSSWSWFFTLVITVAIIYWMIYYLKK 292
Cdd:cd12831  251 FEYMPELKWHYGYFVVLGIMLLIAIGMILWFKK 283
TmCorA-like_u3 cd12832
Uncharacterized subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs ...
189-292 2.37e-08

Uncharacterized subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the TmCorA-like family are found in all three kingdoms of life. It is a functionally diverse family which includes the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and three Saccharomyces cerevisiae proteins: two located in the plasma membrane: the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213366 [Multi-domain]  Cd Length: 287  Bit Score: 54.14  E-value: 2.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642 189 NQRQDQHIDDVAVEYEESKYMFDVLDEIVSQIEDTYSNIINNNLNDVMKVLTVWSlILAIP-PIISGFYGMNVNVLPFAN 267
Cdd:cd12832  180 PLKSDPYTQDLRDLLIKLLSLYDELHENATNLLSLYISLSSQRTNEVMRVLTIFS-VFFLPlTFIAGVYGMNFKYMPELH 258
                         90       100
                 ....*....|....*....|....*...
gi 935564642 268 SSWSWFFTL---VITVAIIYWmIYYLKK 292
Cdd:cd12832  259 WKYGYPATLlvmIVIVVGIYF-WFKRKG 285
MIT_CorA-like cd11744
metal ion transporter CorA-like divalent cation transporter superfamily; This superfamily of ...
215-292 8.19e-08

metal ion transporter CorA-like divalent cation transporter superfamily; This superfamily of essential membrane proteins is involved in transporting divalent cations (uptake or efflux) across membranes. They are found in most bacteria and archaea, and in some eukaryotes. It is a functionally diverse group which includes the Mg2+ transporters of Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and the Zn2+ transporter Salmonella typhimurium ZntB, which mediates the efflux of Zn2+ (and Cd2+). It includes five Saccharomyces cerevisiae members: i) two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, ii) two mitochondrial inner membrane Mg2+ transporters: Mfm1p/Lpe10p, and Mrs2p, and iii) and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. It also includes a family of Arabidopsis thaliana members (AtMGTs), some of which are localized to distinct tissues, and not all of which can transport Mg2+. Thermotoga maritima CorA and Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, Mrs2p, and Alr1p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213354 [Multi-domain]  Cd Length: 286  Bit Score: 52.59  E-value: 8.19e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 935564642 215 EIVSQIEDTYSNIINNNLNDVMKVLTVWSLILAIPPIISGFYGMNVNVLPfANSSWSWFFTLVITVAIIYWMIYYLKK 292
Cdd:cd11744  206 GEVALLQDEIKHNRDEKTNKNSKLFTLVATIFLPTTFLAGLYGMNFEGMP-GVESSMAFTWFCIALIVAFGLEWLLFK 282
Alr1p-like cd12829
Saccharomyces cerevisiae Alr1p-like subfamily; This eukaryotic subfamily belongs to the ...
208-293 1.30e-07

Saccharomyces cerevisiae Alr1p-like subfamily; This eukaryotic subfamily belongs to the Thermotoga maritima CorA (TmCorA)-family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes three Saccharomyces cerevisiae members: two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213363 [Multi-domain]  Cd Length: 305  Bit Score: 51.88  E-value: 1.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642 208 YMFDVLDEIV-------------SQIEDTYSNIIN-------NNLNDVMKVLTVWSLILAIPPIISGFYGMNVNVlPF-- 265
Cdd:cd12829  197 YLGDVQDHILtllqklnhyedllSRSHSNYLAQLSlemsqesNGTDKAMLRLTVIATIFLPLQLITGLFGMNVKV-PGqd 275
                         90       100
                 ....*....|....*....|....*....
gi 935564642 266 -ANSSWSWFFTLVITVAIIYWMIYYLKKH 293
Cdd:cd12829  276 iESLYWFFGIVIVAIMVLVAIVVVFLVRR 304
EcCorA_ZntB-like_u1 cd12826
uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB ...
213-296 9.61e-07

uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; A uncharacterized subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB (EcCorA-ZntB_like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. The EcCorA-ZntB_like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA-ZntB_like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213360  Cd Length: 281  Bit Score: 49.10  E-value: 9.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642 213 LDEIVSQIEDTYSNIINNNLNDVMKVLTVWSLILAIPPIISGFYGMNVNVLPFANSSWSWFFTLVITVAIIYWMIYYLKK 292
Cdd:cd12826  198 LREYSLQIRELYQSQIDIRQNRIMKILTVVTTIFLPLTLITGWYGMNFTNMPELHWKYGYPVVIILSILIVVIEIIYFKK 277

                 ....
gi 935564642 293 HHDL 296
Cdd:cd12826  278 KKWL 281
Mrs2_Mfm1p-like cd12823
Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like ...
193-293 1.12e-06

Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family; A eukaryotic subfamily belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This functionally diverse subfamily includes the inner mitochondrial membrane Mg2+ transporters Saccharomyces cerevisiae Mfm1p/Lpe10p, Mrs2p, and human MRS2/ MRS2L. It also includes a family of Arabidopsis thaliana proteins (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of two EcCorA_ZntB-like family transporters: Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213357  Cd Length: 323  Bit Score: 49.16  E-value: 1.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642 193 DQHIDDVAVEyeeskymfdvLDEIVSQIEDT--YSNII-NNNLNDVMK---VLTVWSLILAIPPIISGFYGMNVNVLPFA 266
Cdd:cd12823  222 LQQVDELLNK----------LEELREYIDDTeeLINLIlDSRRNQLMRlelKLSIGTLSLAVGTLVAGLFGMNLPSGLEE 291
                         90       100       110
                 ....*....|....*....|....*....|
gi 935564642 267 NSSWSWFFTLVI---TVAIIYWMIYYLKKH 293
Cdd:cd12823  292 SPYAFWIVTGGSvvgSILIFIVVLRYLRRK 321
HpCorA-like cd12836
Mg2+ transporter Helicobacter pylori CorA-like subgroup; A bacterial subgroup of the ...
184-292 2.81e-06

Mg2+ transporter Helicobacter pylori CorA-like subgroup; A bacterial subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Mg2+ transporter Helicobacter pylori CorAs (which can also transport Co2+, and Ni2+); CorA plays an important role in the viability of this pathogen. Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB (members of the EcCorA_ZntB-like family) form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213370 [Multi-domain]  Cd Length: 288  Bit Score: 47.64  E-value: 2.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642 184 IPISFNQRQDQHIDDVAVEYEESKYMFDVLDeivsQIEDTYSNIINNNLNDVMKVLTVWSLILAIPPIISGFYGMNVNVL 263
Cdd:cd12836  180 FPEDLKENLRIMIKDINSLIEHTTFNFERLD----YLQNTFLGLINIEQNKIIKIFTVATVIFMPPTLIASIYGMNFKFM 255
                         90       100
                 ....*....|....*....|....*....
gi 935564642 264 PFANSSWSWFFTLVITVAIIYWMIYYLKK 292
Cdd:cd12836  256 PELDWKYGYPFALLLMVISSILPLLYFKK 284
ZntB_u1 cd12834
Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like ...
214-291 5.44e-06

Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; The MIT superfamily of essential membrane proteins is involved in transporting divalent cations (uptake or efflux) across membranes. The ZntB-like subfamily includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213368 [Multi-domain]  Cd Length: 290  Bit Score: 46.81  E-value: 5.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642 214 DEIVSQI-EDTysniiNNNLNdVMKVLTVwsliLAIPP-IISGFYGMNVNVLPFANSSWSwFFTLVITVAII----YWMI 287
Cdd:cd12834  216 EEIAARLaEQT-----NRSLY-ILSVVTA----LLLPPtLVTGLFGMNTGGLPLAEGPHG-FWIAVALALLAaglaYLLL 284

                 ....
gi 935564642 288 YYLK 291
Cdd:cd12834  285 RRLG 288
EcCorA-like_u1 cd12837
uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; A ...
228-285 8.01e-06

uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; A uncharacterized subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. The EcCorA_ZntB-like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA_ZntB-like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213371 [Multi-domain]  Cd Length: 298  Bit Score: 46.37  E-value: 8.01e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 935564642 228 INNNLNDVMKVLTVWSLILaIPP-IISGFYGMNVNVLPFANSSWSWFFTLVITV--AII-YW 285
Cdd:cd12837  230 INIEQNNIIKIFSVASVVF-LPPtLIASIYGMNFKHMPELDWPFGYPLALGLMVlsAVLpLL 290
EcCorA-like cd12825
Escherichia coli Mg2+ transporter CorA_like subfamily; A bacterial subfamily of the ...
69-292 1.28e-05

Escherichia coli Mg2+ transporter CorA_like subfamily; A bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB_like(EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporters Escherichia coli, Salmonella typhimurium, and Helicobacter pylori CorAs (which can also transport Co2+, and Ni2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213359 [Multi-domain]  Cd Length: 287  Bit Score: 45.77  E-value: 1.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642  69 QDENVQTSPVVIAFTNDLIITksdSRYRIKQ-----ETRCNKFDMVFNMLQRINKPYMN-KLDQINESVENLQNKRS--- 139
Cdd:cd12825   56 KEDTIEEEPVTFIIKGNILFT---IRYRDLPafdifPKRAFSQRKFFNSGEELFLFLFEvIVDYLADILENISKKIKqls 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642 140 -----KNSVNNHHLNEIAILKNDLVYLKTATAANIMSINQLQKSsdnFEIPISFNQRQDQHIDDVAVEYEESKYMFDVLD 214
Cdd:cd12825  133 reileEKQFSEEDLDALTKLNENNITLRESLIEKQRIITLLLKS---PRENSDTKEKLKIELRDLSSLLDHTTFNFDKLD 209
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 935564642 215 EIvsqiEDTYSNIINNNLNDVMKVLTVWSLILAIPPIISGFYGMNVNVLPFANSSWSWFFTLVITVAIIYWMIYYLKK 292
Cdd:cd12825  210 DL----KNNILGKIELEQNKIIKIFTVVTVCFLPPTLIASIYGMNFKNMPELKWSYGYPFALILMILSTILPLLYFKR 283
ZntB-like_1 cd12833
Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; A bacterial subgroup belonging to ...
209-291 1.48e-04

Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; A bacterial subgroup belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213367 [Multi-domain]  Cd Length: 290  Bit Score: 42.48  E-value: 1.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642 209 MFDVLDEIVSQ---IEDTYSNIINNNLNDVMKVLTVWSLILAIPPIISGFYGMNVNVLPFANSSWS-WFFT--LVITVAI 282
Cdd:cd12833  200 YIEDLDAIRERaavLQEELTNRRAEQMNRRMYVLSIVAAIFLPLGFLTGLLGINVGGIPGAENPWAfWIFCglLVVLAVG 279

                 ....*....
gi 935564642 283 IYWMIYYLK 291
Cdd:cd12833  280 LLLLFRRKK 288
ZntB-like cd12824
Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; A bacterial subfamily belonging ...
211-293 2.49e-04

Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; A bacterial subfamily belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213358 [Multi-domain]  Cd Length: 290  Bit Score: 41.74  E-value: 2.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 935564642 211 DVLDEIVSQIEDTYSNIINNNLNDVMKVLTVWSLILAIPPIISGFYGMNVNVLPFANSSWS-WFFT-LVITVAIIYWMIY 288
Cdd:cd12824  205 DFCRTRVALLQDEIKAQRDEKTTRSSLLLTVVATVFLPLTFITGLLGMNVGGIPDVESPMGfWWVTgLSILVALLAWLLL 284

                 ....*
gi 935564642 289 YLKKH 293
Cdd:cd12824  285 RRLGH 289
EcCorA-like_1 cd12835
Escherichia coli Mg2+ transporter CorA_like subgroup; A bacterial subgroup of the Escherichia ...
222-290 2.89e-04

Escherichia coli Mg2+ transporter CorA_like subgroup; A bacterial subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Mg2+ transporters Escherichia coli CorA and Salmonella typhimurium CorA (which can also transport Co2+, and Ni2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213369  Cd Length: 287  Bit Score: 41.86  E-value: 2.89e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 935564642 222 DTYSNIINNNLNDVMKVLTVWSLILAIPPIISGFYGMNVNVLPFAnsSWSWFFTLVITVAIIYWMIYYL 290
Cdd:cd12835  213 DAAMGFINIEQNKIIKIFSVAAVVFLPPTLIASIYGMNFDFMPEL--DWKFGYPMAIGLMILSAIAPYL 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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