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Conserved domains on  [gi|937073987|ref|WP_054542537|]
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MULTISPECIES: efflux RND transporter permease subunit [Vibrio]

Protein Classification

efflux RND transporter permease subunit( domain architecture ID 1750079)

efflux RND transporter permease subunit is an efflux membrane protein that can confer resistance to various compounds/drugs, similar to Legionella pneumophila efflux pump LpeAB

Gene Ontology:  GO:0015562
PubMed:  19026770|10941792
TCDB:  2.A.6

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
ACR_tran super family cl47191
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
4-1006 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


The actual alignment was detected with superfamily member NF033617:

Pssm-ID: 481531 [Multi-domain]  Cd Length: 1009  Bit Score: 1099.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987    4 TDVFIKRPVLATVLSLVLLVLGLKAFTSLQVRQYPEIETGVITITTSYPGASASSVQGYVTQPLQAEIAQTAGIDYMTSD 83
Cdd:NF033617    1 SDVFIKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   84 SALGKSVITVYLKLGYPSDSALTEILSLVQQVKYKLPSGVLDPSILKST--SQSPILYVSFSSDTLKTEQVSDYVSRVVK 161
Cdd:NF033617   81 SSLGYSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEAPDPPVYRKAnsADTPIMYIGLTSEEMPRGQLTDYAERVLA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  162 PTFSTVEGVSKVDILGQEDFAMRIWLNPQRLASYGLTAEDVQNALRANNIVSAAGKLQNPYIEVDINAHTDSSSVDDFKN 241
Cdd:NF033617  161 PKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDYED 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  242 MALK-AHDGQLVHLKDVATVELGAANYDSDVEFNGVTTVSTAISNTATSNPLTVVEGIYELLPQIQAGLPEGIKADVIYD 320
Cdd:NF033617  241 LVIKyADNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLPKNIKVNVLYD 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  321 STKFIETSIDEVAKTLIEAALIVVIVIFAFLGSMRAMLIPLVTIPLSLIGSMFFMLSMGFSINLLTLLAMVLAISLVVDD 400
Cdd:NF033617  321 RTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVDD 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  401 AIVVVENTFRHLEDGTSPIKAAIDSAREIAGSVIAMTITLAAVYAPIGFMGGLTGKLFTEFAFTLAGSVLISGFIALTLT 480
Cdd:NF033617  401 AIVVVENIHRHIEEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREFAVTLAGAVIISGIVALTLT 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  481 PMMCSKLLNKSVLDGKLVKKIDAVIEGVTERYRKVLEHVLNNRvyiWPVVGTLLI---SLVFMFMNTSSELAPEEDQGVM 557
Cdd:NF033617  481 PMMCSRLLKANEKPGRFARAVDRFFDGLTARYGRGLKWVLKHR---PLTLVVALAtlaLLPLLYVFIPKELAPSEDRGVI 557
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  558 IVMGQGPAQANTDYIRHFTPALIDSISKNDEVEMT---MLDNGYMNNNAFFGLGVLKDWDSRDATAKEVMQRFEKESSVL 634
Cdd:NF033617  558 FGMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLtsfNGVGGNPGDNTGFGIINLKPWDERDVSAQEIIDRLRPKLAKV 637
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  635 PGLQVYTFSPPDLPG-TPQGLPFQMVLKTPTgSYQDLYQYAEKLKEYAQKSGKFIYVQNDLNFNKPQVEIRIDRDKAAQM 713
Cdd:NF033617  638 PGMDLFLFPLQDLPGgAGSSLPQYQVTLTPS-DYDSLFTWAEKLKEKLRKSPQFADVDSDLQDKGPELNVDIDRDKAARL 716
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  714 NVNAQDIGTVLSRFISEGFVNYFSMDQRSYQVITQVPNENRNSWDDLKNYHVRSNTNEMVPLASLIEISQSVQPSKVDQF 793
Cdd:NF033617  717 GISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQIYVRSNDGKLVPLSTLAKIEERAAPLSLNHF 796
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  794 QQLNSAMIEAKMMPGISIGEAYKVMEEGAAKILPKSYTTDTSGQLRQFLQEGSSLVTTFFLALVIIYLVLAAQFESLRDP 873
Cdd:NF033617  797 NQFNSATLSFNLAPGVSLGEAIEALDQAAKELLPSGISGSFQGAARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDP 876
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  874 LVVLTSVPLSIFGALMPLYLGIDTLNIYTEVGLVTLIGLISKHGILIVEFANQMQQELKCSRREAAIRSATVRMRPVLMT 953
Cdd:NF033617  877 LTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVEFANELQRHQGLSRREAIYQAAALRLRPILMT 956
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|...
gi 937073987  954 TAAMVVGVVPLLIASGAGAQSRFSIGLVITVGMSVGTLFTLFVVPTIYTYLAA 1006
Cdd:NF033617  957 TLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLPVVYLLLAR 1009
 
Name Accession Description Interval E-value
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
4-1006 0e+00

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 1099.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987    4 TDVFIKRPVLATVLSLVLLVLGLKAFTSLQVRQYPEIETGVITITTSYPGASASSVQGYVTQPLQAEIAQTAGIDYMTSD 83
Cdd:NF033617    1 SDVFIKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   84 SALGKSVITVYLKLGYPSDSALTEILSLVQQVKYKLPSGVLDPSILKST--SQSPILYVSFSSDTLKTEQVSDYVSRVVK 161
Cdd:NF033617   81 SSLGYSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEAPDPPVYRKAnsADTPIMYIGLTSEEMPRGQLTDYAERVLA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  162 PTFSTVEGVSKVDILGQEDFAMRIWLNPQRLASYGLTAEDVQNALRANNIVSAAGKLQNPYIEVDINAHTDSSSVDDFKN 241
Cdd:NF033617  161 PKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDYED 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  242 MALK-AHDGQLVHLKDVATVELGAANYDSDVEFNGVTTVSTAISNTATSNPLTVVEGIYELLPQIQAGLPEGIKADVIYD 320
Cdd:NF033617  241 LVIKyADNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLPKNIKVNVLYD 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  321 STKFIETSIDEVAKTLIEAALIVVIVIFAFLGSMRAMLIPLVTIPLSLIGSMFFMLSMGFSINLLTLLAMVLAISLVVDD 400
Cdd:NF033617  321 RTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVDD 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  401 AIVVVENTFRHLEDGTSPIKAAIDSAREIAGSVIAMTITLAAVYAPIGFMGGLTGKLFTEFAFTLAGSVLISGFIALTLT 480
Cdd:NF033617  401 AIVVVENIHRHIEEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREFAVTLAGAVIISGIVALTLT 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  481 PMMCSKLLNKSVLDGKLVKKIDAVIEGVTERYRKVLEHVLNNRvyiWPVVGTLLI---SLVFMFMNTSSELAPEEDQGVM 557
Cdd:NF033617  481 PMMCSRLLKANEKPGRFARAVDRFFDGLTARYGRGLKWVLKHR---PLTLVVALAtlaLLPLLYVFIPKELAPSEDRGVI 557
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  558 IVMGQGPAQANTDYIRHFTPALIDSISKNDEVEMT---MLDNGYMNNNAFFGLGVLKDWDSRDATAKEVMQRFEKESSVL 634
Cdd:NF033617  558 FGMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLtsfNGVGGNPGDNTGFGIINLKPWDERDVSAQEIIDRLRPKLAKV 637
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  635 PGLQVYTFSPPDLPG-TPQGLPFQMVLKTPTgSYQDLYQYAEKLKEYAQKSGKFIYVQNDLNFNKPQVEIRIDRDKAAQM 713
Cdd:NF033617  638 PGMDLFLFPLQDLPGgAGSSLPQYQVTLTPS-DYDSLFTWAEKLKEKLRKSPQFADVDSDLQDKGPELNVDIDRDKAARL 716
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  714 NVNAQDIGTVLSRFISEGFVNYFSMDQRSYQVITQVPNENRNSWDDLKNYHVRSNTNEMVPLASLIEISQSVQPSKVDQF 793
Cdd:NF033617  717 GISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQIYVRSNDGKLVPLSTLAKIEERAAPLSLNHF 796
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  794 QQLNSAMIEAKMMPGISIGEAYKVMEEGAAKILPKSYTTDTSGQLRQFLQEGSSLVTTFFLALVIIYLVLAAQFESLRDP 873
Cdd:NF033617  797 NQFNSATLSFNLAPGVSLGEAIEALDQAAKELLPSGISGSFQGAARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDP 876
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  874 LVVLTSVPLSIFGALMPLYLGIDTLNIYTEVGLVTLIGLISKHGILIVEFANQMQQELKCSRREAAIRSATVRMRPVLMT 953
Cdd:NF033617  877 LTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVEFANELQRHQGLSRREAIYQAAALRLRPILMT 956
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|...
gi 937073987  954 TAAMVVGVVPLLIASGAGAQSRFSIGLVITVGMSVGTLFTLFVVPTIYTYLAA 1006
Cdd:NF033617  957 TLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLPVVYLLLAR 1009
PRK09579 PRK09579
multidrug efflux RND transporter permease subunit;
1-1005 0e+00

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169983 [Multi-domain]  Cd Length: 1017  Bit Score: 1059.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987    1 MTFTDVFIKRPVLATVLSLVLLVLGLKAFTSLQVRQYPEIETGVITITTSYPGASASSVQGYVTQPLQAEIAQTAGIDYM 80
Cdd:PRK09579    1 MAFTDPFIRRPVLASVVSLLIVLLGFQAWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   81 TSDSALGKSVITVYLKLGYPSDSALTEILSLVQQVKYKLPSGVLDPSILKSTSQ-SPILYVSFSSDTLKTEQVSDYVSRV 159
Cdd:PRK09579   81 TSVSRQNFSIISIYARIGADSDRLFTELLAKANEVKNQLPQDAEDPVLSKEAADaSALMYISFYSEEMSNPQITDYLSRV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  160 VKPTFSTVEGVSKVDILGQEDFAMRIWLNPQRLASYGLTAEDVQNALRANNIVSAAGKLQNPYIEVDINAHTDSSSVDDF 239
Cdd:PRK09579  161 IQPKLATLPGMAEAEILGNQVFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNFLSAAGEVKGEYVVTSINASTELKSAEAF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  240 KNMALKAHDGQLVHLKDVATVELGAANYDSDVEFNGVTTVSTAISNTATSNPLTVVEGIYELLPQIQAGLPEGIKADVIY 319
Cdd:PRK09579  241 AAIPVKTSGDSRVLLGDVARVEMGAENYDSISSFDGIPSVYIGIKATPSANPLDVIKEVRAIMPELESQLPPNLKVSIAY 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  320 DSTKFIETSIDEVAKTLIEAALIVVIVIFAFLGSMRAMLIPLVTIPLSLIGSMFFMLSMGFSINLLTLLAMVLAISLVVD 399
Cdd:PRK09579  321 DATLFIQASIDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTLLAMVLAIGLVVD 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  400 DAIVVVENTFRHLEDGTSPIKAAIDSAREIAGSVIAMTITLAAVYAPIGFMGGLTGKLFTEFAFTLAGSVLISGFIALTL 479
Cdd:PRK09579  401 DAIVVVENIHRHIEEGKSPFDAALEGAREIAMPVVSMTITLAAVYAPIGFLTGLTGALFKEFALTLAGAVIISGIVALTL 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  480 TPMMCSKLLNKSVLDGKLVKKIDAVIEGVTERYRKVLEHVLNNR--VYIWPVVGTLLISLVFMFmnTSSELAPEEDQGVM 557
Cdd:PRK09579  481 SPMMCALLLRHEENPSGLAHRLDRLFERLKQRYQRALHGTLNTRpvVLVFAVIVLALIPVLLKF--TQSELAPEEDQGII 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  558 IVMGQGPAQANTDYIRHFTPALIDSISKNDEVEMTMLDNGYMNNNAFFGLGVLKDWDSRDATAKEVMQRFEKESSVLPGL 637
Cdd:PRK09579  559 FMMSSSPQPANLDYLNAYTDEFTPIFKSFPEYYSSFQINGFNGVQSGIGGFLLKPWNERERTQMELLPLVQAKLEEIPGL 638
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  638 QVYTFSPPDLPGTPQGLPFQMVLKTPtGSYQDLYQYAEKLKEYAQKSGKFIYVQNDLNFNKPQVEIRIDRDKAAQMNVNA 717
Cdd:PRK09579  639 QIFGFNLPSLPGTGEGLPFQFVINTA-NDYESLLQVAQRVKQRAQESGKFAFLDIDLAFDKPEVVVDIDRAKAAQMGVSM 717
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  718 QDIGTVLSRFISEGFVNYFSMDQRSYQVITQVPNENRNSWDDLKNYHVRSNTNEMVPLASLIEISQSVQPSKVDQFQQLN 797
Cdd:PRK09579  718 QDLGGTLATLLGEGEINRFTIDGRSYKVIAQVERPYRDNPGWLNNYYVKNEQGQLLPLSTLITLSDRARPRQLNQFQQLN 797
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  798 SAMIEAkmMPGISIGEAYKVMEEGAAKILPKSYTTDTSGQLRQFLQEGSSLVTTFFLALVIIYLVLAAQFESLRDPLVVL 877
Cdd:PRK09579  798 SAIISG--FPIVSMGEAIETVQQIAREEAPEGFAFDYAGASRQYVQEGSALWVTFGLALAIIFLVLAAQFESFRDPLVIL 875
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  878 TSVPLSIFGALMPLYLGIDTLNIYTEVGLVTLIGLISKHGILIVEFANQMQQELKCSRREAAIRSATVRMRPVLMTTAAM 957
Cdd:PRK09579  876 VTVPLSICGALIPLFLGVSSMNIYTQVGLVTLIGLISKHGILIVEFANQLRHEQGLSRREAIEEAAAIRLRPVLMTTAAM 955
                         970       980       990      1000
                  ....*....|....*....|....*....|....*....|....*...
gi 937073987  958 VVGVVPLLIASGAGAQSRFSIGLVITVGMSVGTLFTLFVVPTIYTYLA 1005
Cdd:PRK09579  956 VFGMVPLILATGAGAVSRFDIGLVIATGMSIGTLFTLFVLPCIYTLLA 1003
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
1-1009 0e+00

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 1056.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987    1 MTFTDVFIKRPVLATVLSLVLLVLGLKAFTSLQVRQYPEIETGVITITTSYPGASASSVQGYVTQPLQAEIAQTAGIDYM 80
Cdd:COG0841     1 MNLSRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   81 TSDSALGKSVITVYLKLGYPSDSALTEILSLVQQVKYKLPSGVLDPSILK-STSQSPILYVSFSSDTLKTEQVSDYVSRV 159
Cdd:COG0841    81 TSTSSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDLPEDVEPPGVTKvNPSDFPVMVLALSSDDLDELELSDYAERN 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  160 VKPTFSTVEGVSKVDILGQEDFAMRIWLNPQRLASYGLTAEDVQNALRANNIVSAAGKLQNPYIEVDINAHTDSSSVDDF 239
Cdd:COG0841   161 IKDRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEEF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  240 KNMALKAHDGQLVHLKDVATVELGAANYDSDVEFNGVTTVSTAISNTATSNPLTVVEGIYELLPQIQAGLPEGIKADVIY 319
Cdd:COG0841   241 ENIVIRTNDGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASLPEGVELTIVY 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  320 DSTKFIETSIDEVAKTLIEAALIVVIVIFAFLGSMRAMLIPLVTIPLSLIGSMFFMLSMGFSINLLTLLAMVLAISLVVD 399
Cdd:COG0841   321 DQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGIVVD 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  400 DAIVVVENTFRHLEDGTSPIKAAIDSAREIAGSVIAMTITLAAVYAPIGFMGGLTGKLFTEFAFTLAGSVLISGFIALTL 479
Cdd:COG0841   401 DAIVVVENIERHMEEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFALTVAIALLISLFVALTL 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  480 TPMMCSKLLNKSVLD--GKLVKKIDAVIEGVTERYRKVLEHVLNNRVYIWPVVGTLLISLVFMFMNTSSELAPEEDQGVM 557
Cdd:COG0841   481 TPALCARLLKPHPKGkkGRFFRAFNRGFDRLTRGYGRLLRWALRHRKLTLLVALALLALSVLLFGRLPTEFFPEEDQGQI 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  558 IVMGQGPAQANTDYIRHFTPALIDSISKNDEVEMTMLDNGYMN-----NNAFFGLgVLKDWDSRDATAKEVMQRFEKESS 632
Cdd:COG0841   561 IVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSGggsgsNSGTIFV-TLKPWDERDRSADEIIARLREKLA 639
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  633 VLPGLQVYTFSPPDlPGTPQGLPFQMVLKTPtgSYQDLYQYAEKLKEYAQKSGKFIYVQNDLNFNKPQVEIRIDRDKAAQ 712
Cdd:COG0841   640 KIPGARVFVFQPPA-GGLGSGAPIEVQLQGD--DLEELAAAAEKLLAALRQIPGLVDVRSDLQLGKPELQLDIDREKAAA 716
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  713 MNVNAQDIGTVLSRFISEGFVNYFSMDQRSYQVITQVPNENRNSWDDLKNYHVRSNTNEMVPLASLIEISQSVQPSKVDQ 792
Cdd:COG0841   717 LGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYVRTPDGEMVPLSSVATIEEGTGPSSINR 796
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  793 FQQLNSAMIEAKMMPGISIGEAYKVMEEGAAKI-LPKSYTTDTSGQLRQFLQEGSSLVTTFFLALVIIYLVLAAQFESLR 871
Cdd:COG0841   797 YNGQRSVTVSANLAPGVSLGEALAAIEELAAELkLPPGVSIEFTGQAEEEQESFSSLGLAFLLALLLVYLVLAAQFESFI 876
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  872 DPLVVLTSVPLSIFGALMPLYLGIDTLNIYTEVGLVTLIGLISKHGILIVEFANQMQQELKcSRREAAIRSATVRMRPVL 951
Cdd:COG0841   877 QPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFANQLREEGM-SLREAILEAARLRLRPIL 955
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 937073987  952 MTTAAMVVGVVPLLIASGAGAQSRFSIGLVITVGMSVGTLFTLFVVPTIYTYLAADHR 1009
Cdd:COG0841   956 MTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLLDRLRR 1013
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
3-1001 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 785.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987     3 FTDVFIKRPVLATVLSLVLLVLGLKAFTSLQVRQYPEIETGVITITTSYPGASASSVQGYVTQPLQAEIAQTAGIDYMTS 82
Cdd:pfam00873    1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987    83 DSALGKSVITVYLKLGYPSDSALTEILSLVQQVKYKLPSGVLDPSILK-STSQSPILYVSFSSD--TLKTEQVSDYVSRV 159
Cdd:pfam00873   81 QSSYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGVQRPGISViKTSLGPIMVLAVTSPdgSYTQTDLRDYADTN 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   160 VKPTFSTVEGVSKVDILGQEDFAMRIWLNPQRLASYGLTAEDVQNALRANNIVSAAGKLQNPYIEVDINAHTDSSSVDDF 239
Cdd:pfam00873  161 IKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAEDF 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   240 KNMALKAHDGQLVHLKDVATVELGAANYDSDVEFNGVTTVSTAISNTATSNPLTVVEGIYELLPQIQAGLPEGIKADVIY 319
Cdd:pfam00873  241 EKIIVKNQDGSPVRLRDVATVELGSELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQGVEIVVVY 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   320 DSTKFIETSIDEVAKTLIEAALIVVIVIFAFLGSMRAMLIPLVTIPLSLIGSMFFMLSMGFSINLLTLLAMVLAISLVVD 399
Cdd:pfam00873  321 DTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLAIGLVVD 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   400 DAIVVVENTFRHL-EDGTSPIKAAIDSAREIAGSVIAMTITLAAVYAPIGFMGGLTGKLFTEFAFTLAGSVLISGFIALT 478
Cdd:pfam00873  401 DAIVVVENIERVLeENGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIVLAILLSVLVALT 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   479 LTPMMCSKLLNKSVL--DGKLVKKIDAVIEGVTERYRKVLEHVLNNRVYIWPVVGTLLISLVFMFMNTSSELAPEEDQGV 556
Cdd:pfam00873  481 LTPALCATLLKPRREpkHGGFFRWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWLFVRIPTEFLPEEDEGV 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   557 MIVMGQGPAQANTDYIRHFTPALIDSISKNDEVEMTMLDNGY----MNNNAFFGLG--VLKDWDSRDA---TAKEVMQRF 627
Cdd:pfam00873  561 FVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFafsgDNNGPNSGDAfiSLKPWKERPGpekSVQALIERL 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   628 EKESSVLPGLQVYTFSPPDL--PGTPQGLPFQMVLKTPTGSYQDLYQYAEKLKEYAQKSGKFIYVQNDLNFNKPQVEIRI 705
Cdd:pfam00873  641 RKALKQIPGANVFLFQPIQLrgLGTISGFRSDLQVKIFGDDLDALDEARNQILAALAQLPGLSDVRSDGQEDQPQLQVNI 720
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   706 DRDKAAQMNVNAQDIGTVLSRFISEGFVNYFSMDQRSYQVITQVPNENRNSWDDLKNYHVRSNTNEMVPLASLIEISQSV 785
Cdd:pfam00873  721 DREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNPYGKMIPLSAFAKIEWGY 800
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   786 QPSKVDQFQQLNSAMIEAKMMPGISIGEAYKVMEEGAAKI-LPKSYTTDTSGQLRQFLQEGSSLVTTFFLALVIIYLVLA 864
Cdd:pfam00873  801 GPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVkLPPGYGYTWTGQFEQEQLAGNSLPILIALALLVVFLVLA 880
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   865 AQFESLRDPLVVLTSVPLSIFGALMPLYLGIDTLNIYTEVGLVTLIGLISKHGILIVEFANQMQQELKCSRREAAIRSAT 944
Cdd:pfam00873  881 ALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANELREQEGKSLEEAILEACR 960
                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 937073987   945 VRMRPVLMTTAAMVVGVVPLLIASGAGAQSRFSIGLVITVGMSVGTLFTLFVVPTIY 1001
Cdd:pfam00873  961 LRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPVFY 1017
2A0602 TIGR00915
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ...
3-1001 0e+00

The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]


Pssm-ID: 273335 [Multi-domain]  Cd Length: 1044  Bit Score: 653.34  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987     3 FTDVFIKRPVLATVLSLVLLVLGLKAFTSLQVRQYPEIETGVITITTSYPGASASSVQGYVTQPLQAEIAQTAGIDYMTS 82
Cdd:TIGR00915    1 MAKFFIDRPIFAWVIAIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987    83 DSA-LGKSVITVYLKLGYPSDSALTEILSLVQQVKYKLPSGVLDPSI-LKSTSQSPILYVSFSSD--TLKTEQVSDYVSR 158
Cdd:TIGR00915   81 SSDsDGSMTITLTFEQGTDPDIAQVQVQNKLQLATPLLPQEVQRQGVrVEKASSNFLMVIGLVSDdgSMTKEDLSDYAAS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   159 VVKPTFSTVEGVSKVDILGQEdFAMRIWLNPQRLASYGLTAEDVQNALRANNIVSAAGKL------QNPYIEVDINAHTD 232
Cdd:TIGR00915  161 NMVDPLSRLEGVGDVQLFGSQ-YAMRIWLDPAKLNSYQLTPADVISAISAQNAQISAGQLgglpavPGQQLNATIIAQTR 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   233 SSSVDDFKNMALKAH-DGQLVHLKDVATVELGAANYDSDVEFNGVTTVSTAISNTATSNPLTVVEGIYELLPQIQAGLPE 311
Cdd:TIGR00915  240 LQTPEQFENILLKVNtDGSQVRLKDVARVELGGENYSISARFNGKPASGLAIKLATGANALDTAKAVKAELAVLEPFFPQ 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   312 GIKADVIYDSTKFIETSIDEVAKTLIEAALIVVIVIFAFLGSMRAMLIPLVTIPLSLIGSMFFMLSMGFSINLLTLLAMV 391
Cdd:TIGR00915  320 GMKYVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAMV 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   392 LAISLVVDDAIVVVENTFRHL-EDGTSPIKAAIDSAREIAGSVIAMTITLAAVYAPIGFMGGLTGKLFTEFAFTLAGSVL 470
Cdd:TIGR00915  400 LAIGLLVDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMA 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   471 ISGFIALTLTPMMCSKLL------NKSVLDGKLVKKIDAVIEGVTERYRKVLEHVLNNRVYIWPVVGTLLISLVFMFMNT 544
Cdd:TIGR00915  480 LSVLVALILTPALCATMLkpiekgEHHEKKGGFFGWFNRMFDSSTHGYENGVGKILRRRGRYLLVYVLLVGGMVFLFVRL 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   545 SSELAPEEDQGVMIVMGQGPAQANTDYirhfTPALIDSISK------NDEVEMTMLDNGYM----NNNAFFGLGVLKDWD 614
Cdd:TIGR00915  560 PTSFLPDEDQGVFMTIVQLPAGATAER----TQAVLAQVTKyllakeKANVESVFTVNGFSfagrGQNMGMAFIRLKDWE 635
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   615 SRDA---TAKEVMQRFEKESSVLPGLQVYTFSPPDLPGTPQGLPFQMVLKTPTGSYQD-LYQYAEKLKEYAQKSGKFIYV 690
Cdd:TIGR00915  636 ERTGkenSVFAIAGRATGHFMQIKDAMVIAFVPPAILELGNATGFDFFLQDRAGLGHEaLLQARNQLLGLAAQNPALTRV 715
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   691 QNDLNFNKPQVEIRIDRDKAAQMNVNAQDIGTVLSRFISEGFVNYFSMDQRSYQVITQVPNENRNSWDDLKNYHVRSNTN 770
Cdd:TIGR00915  716 RPNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINKWYVRNASG 795
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   771 EMVPLASLIEISQSVQPSKVDQFQQLNSAMIEAKMMPGISIGEAYKVMEEGAAKiLPKSYTTDTSGQLRQFLQEGSSLVT 850
Cdd:TIGR00915  796 EMVPFSAFATVRWEYGSPQLERYNGLPSMEILGSAAPGVSTGQAMAAMEAIAQK-LPPGFGFSWTGMSYEERLSGSQAPA 874
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   851 TFFLALVIIYLVLAAQFESLRDPLVVLTSVPLSIFGALMPLYLGIDTLNIYTEVGLVTLIGLISKHGILIVEFANQMQQE 930
Cdd:TIGR00915  875 LYALSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLATTLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFAKELMAQ 954
                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 937073987   931 LKcSRREAAIRSATVRMRPVLMTTAAMVVGVVPLLIASGAGAQSRFSIGLVITVGMSVGTLFTLFVVPTIY 1001
Cdd:TIGR00915  955 GK-SIVEAALEAARLRLRPILMTSLAFILGVVPLAISTGAGSGSQHAIGTGVFGGMVTATVLAIFFVPLFY 1024
 
Name Accession Description Interval E-value
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
4-1006 0e+00

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 1099.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987    4 TDVFIKRPVLATVLSLVLLVLGLKAFTSLQVRQYPEIETGVITITTSYPGASASSVQGYVTQPLQAEIAQTAGIDYMTSD 83
Cdd:NF033617    1 SDVFIKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   84 SALGKSVITVYLKLGYPSDSALTEILSLVQQVKYKLPSGVLDPSILKST--SQSPILYVSFSSDTLKTEQVSDYVSRVVK 161
Cdd:NF033617   81 SSLGYSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEAPDPPVYRKAnsADTPIMYIGLTSEEMPRGQLTDYAERVLA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  162 PTFSTVEGVSKVDILGQEDFAMRIWLNPQRLASYGLTAEDVQNALRANNIVSAAGKLQNPYIEVDINAHTDSSSVDDFKN 241
Cdd:NF033617  161 PKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDYED 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  242 MALK-AHDGQLVHLKDVATVELGAANYDSDVEFNGVTTVSTAISNTATSNPLTVVEGIYELLPQIQAGLPEGIKADVIYD 320
Cdd:NF033617  241 LVIKyADNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLPKNIKVNVLYD 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  321 STKFIETSIDEVAKTLIEAALIVVIVIFAFLGSMRAMLIPLVTIPLSLIGSMFFMLSMGFSINLLTLLAMVLAISLVVDD 400
Cdd:NF033617  321 RTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVDD 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  401 AIVVVENTFRHLEDGTSPIKAAIDSAREIAGSVIAMTITLAAVYAPIGFMGGLTGKLFTEFAFTLAGSVLISGFIALTLT 480
Cdd:NF033617  401 AIVVVENIHRHIEEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREFAVTLAGAVIISGIVALTLT 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  481 PMMCSKLLNKSVLDGKLVKKIDAVIEGVTERYRKVLEHVLNNRvyiWPVVGTLLI---SLVFMFMNTSSELAPEEDQGVM 557
Cdd:NF033617  481 PMMCSRLLKANEKPGRFARAVDRFFDGLTARYGRGLKWVLKHR---PLTLVVALAtlaLLPLLYVFIPKELAPSEDRGVI 557
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  558 IVMGQGPAQANTDYIRHFTPALIDSISKNDEVEMT---MLDNGYMNNNAFFGLGVLKDWDSRDATAKEVMQRFEKESSVL 634
Cdd:NF033617  558 FGMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLtsfNGVGGNPGDNTGFGIINLKPWDERDVSAQEIIDRLRPKLAKV 637
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  635 PGLQVYTFSPPDLPG-TPQGLPFQMVLKTPTgSYQDLYQYAEKLKEYAQKSGKFIYVQNDLNFNKPQVEIRIDRDKAAQM 713
Cdd:NF033617  638 PGMDLFLFPLQDLPGgAGSSLPQYQVTLTPS-DYDSLFTWAEKLKEKLRKSPQFADVDSDLQDKGPELNVDIDRDKAARL 716
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  714 NVNAQDIGTVLSRFISEGFVNYFSMDQRSYQVITQVPNENRNSWDDLKNYHVRSNTNEMVPLASLIEISQSVQPSKVDQF 793
Cdd:NF033617  717 GISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQIYVRSNDGKLVPLSTLAKIEERAAPLSLNHF 796
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  794 QQLNSAMIEAKMMPGISIGEAYKVMEEGAAKILPKSYTTDTSGQLRQFLQEGSSLVTTFFLALVIIYLVLAAQFESLRDP 873
Cdd:NF033617  797 NQFNSATLSFNLAPGVSLGEAIEALDQAAKELLPSGISGSFQGAARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDP 876
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  874 LVVLTSVPLSIFGALMPLYLGIDTLNIYTEVGLVTLIGLISKHGILIVEFANQMQQELKCSRREAAIRSATVRMRPVLMT 953
Cdd:NF033617  877 LTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVEFANELQRHQGLSRREAIYQAAALRLRPILMT 956
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|...
gi 937073987  954 TAAMVVGVVPLLIASGAGAQSRFSIGLVITVGMSVGTLFTLFVVPTIYTYLAA 1006
Cdd:NF033617  957 TLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLPVVYLLLAR 1009
PRK09579 PRK09579
multidrug efflux RND transporter permease subunit;
1-1005 0e+00

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169983 [Multi-domain]  Cd Length: 1017  Bit Score: 1059.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987    1 MTFTDVFIKRPVLATVLSLVLLVLGLKAFTSLQVRQYPEIETGVITITTSYPGASASSVQGYVTQPLQAEIAQTAGIDYM 80
Cdd:PRK09579    1 MAFTDPFIRRPVLASVVSLLIVLLGFQAWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   81 TSDSALGKSVITVYLKLGYPSDSALTEILSLVQQVKYKLPSGVLDPSILKSTSQ-SPILYVSFSSDTLKTEQVSDYVSRV 159
Cdd:PRK09579   81 TSVSRQNFSIISIYARIGADSDRLFTELLAKANEVKNQLPQDAEDPVLSKEAADaSALMYISFYSEEMSNPQITDYLSRV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  160 VKPTFSTVEGVSKVDILGQEDFAMRIWLNPQRLASYGLTAEDVQNALRANNIVSAAGKLQNPYIEVDINAHTDSSSVDDF 239
Cdd:PRK09579  161 IQPKLATLPGMAEAEILGNQVFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNFLSAAGEVKGEYVVTSINASTELKSAEAF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  240 KNMALKAHDGQLVHLKDVATVELGAANYDSDVEFNGVTTVSTAISNTATSNPLTVVEGIYELLPQIQAGLPEGIKADVIY 319
Cdd:PRK09579  241 AAIPVKTSGDSRVLLGDVARVEMGAENYDSISSFDGIPSVYIGIKATPSANPLDVIKEVRAIMPELESQLPPNLKVSIAY 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  320 DSTKFIETSIDEVAKTLIEAALIVVIVIFAFLGSMRAMLIPLVTIPLSLIGSMFFMLSMGFSINLLTLLAMVLAISLVVD 399
Cdd:PRK09579  321 DATLFIQASIDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTLLAMVLAIGLVVD 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  400 DAIVVVENTFRHLEDGTSPIKAAIDSAREIAGSVIAMTITLAAVYAPIGFMGGLTGKLFTEFAFTLAGSVLISGFIALTL 479
Cdd:PRK09579  401 DAIVVVENIHRHIEEGKSPFDAALEGAREIAMPVVSMTITLAAVYAPIGFLTGLTGALFKEFALTLAGAVIISGIVALTL 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  480 TPMMCSKLLNKSVLDGKLVKKIDAVIEGVTERYRKVLEHVLNNR--VYIWPVVGTLLISLVFMFmnTSSELAPEEDQGVM 557
Cdd:PRK09579  481 SPMMCALLLRHEENPSGLAHRLDRLFERLKQRYQRALHGTLNTRpvVLVFAVIVLALIPVLLKF--TQSELAPEEDQGII 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  558 IVMGQGPAQANTDYIRHFTPALIDSISKNDEVEMTMLDNGYMNNNAFFGLGVLKDWDSRDATAKEVMQRFEKESSVLPGL 637
Cdd:PRK09579  559 FMMSSSPQPANLDYLNAYTDEFTPIFKSFPEYYSSFQINGFNGVQSGIGGFLLKPWNERERTQMELLPLVQAKLEEIPGL 638
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  638 QVYTFSPPDLPGTPQGLPFQMVLKTPtGSYQDLYQYAEKLKEYAQKSGKFIYVQNDLNFNKPQVEIRIDRDKAAQMNVNA 717
Cdd:PRK09579  639 QIFGFNLPSLPGTGEGLPFQFVINTA-NDYESLLQVAQRVKQRAQESGKFAFLDIDLAFDKPEVVVDIDRAKAAQMGVSM 717
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  718 QDIGTVLSRFISEGFVNYFSMDQRSYQVITQVPNENRNSWDDLKNYHVRSNTNEMVPLASLIEISQSVQPSKVDQFQQLN 797
Cdd:PRK09579  718 QDLGGTLATLLGEGEINRFTIDGRSYKVIAQVERPYRDNPGWLNNYYVKNEQGQLLPLSTLITLSDRARPRQLNQFQQLN 797
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  798 SAMIEAkmMPGISIGEAYKVMEEGAAKILPKSYTTDTSGQLRQFLQEGSSLVTTFFLALVIIYLVLAAQFESLRDPLVVL 877
Cdd:PRK09579  798 SAIISG--FPIVSMGEAIETVQQIAREEAPEGFAFDYAGASRQYVQEGSALWVTFGLALAIIFLVLAAQFESFRDPLVIL 875
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  878 TSVPLSIFGALMPLYLGIDTLNIYTEVGLVTLIGLISKHGILIVEFANQMQQELKCSRREAAIRSATVRMRPVLMTTAAM 957
Cdd:PRK09579  876 VTVPLSICGALIPLFLGVSSMNIYTQVGLVTLIGLISKHGILIVEFANQLRHEQGLSRREAIEEAAAIRLRPVLMTTAAM 955
                         970       980       990      1000
                  ....*....|....*....|....*....|....*....|....*...
gi 937073987  958 VVGVVPLLIASGAGAQSRFSIGLVITVGMSVGTLFTLFVVPTIYTYLA 1005
Cdd:PRK09579  956 VFGMVPLILATGAGAVSRFDIGLVIATGMSIGTLFTLFVLPCIYTLLA 1003
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
1-1009 0e+00

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 1056.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987    1 MTFTDVFIKRPVLATVLSLVLLVLGLKAFTSLQVRQYPEIETGVITITTSYPGASASSVQGYVTQPLQAEIAQTAGIDYM 80
Cdd:COG0841     1 MNLSRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   81 TSDSALGKSVITVYLKLGYPSDSALTEILSLVQQVKYKLPSGVLDPSILK-STSQSPILYVSFSSDTLKTEQVSDYVSRV 159
Cdd:COG0841    81 TSTSSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDLPEDVEPPGVTKvNPSDFPVMVLALSSDDLDELELSDYAERN 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  160 VKPTFSTVEGVSKVDILGQEDFAMRIWLNPQRLASYGLTAEDVQNALRANNIVSAAGKLQNPYIEVDINAHTDSSSVDDF 239
Cdd:COG0841   161 IKDRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEEF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  240 KNMALKAHDGQLVHLKDVATVELGAANYDSDVEFNGVTTVSTAISNTATSNPLTVVEGIYELLPQIQAGLPEGIKADVIY 319
Cdd:COG0841   241 ENIVIRTNDGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASLPEGVELTIVY 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  320 DSTKFIETSIDEVAKTLIEAALIVVIVIFAFLGSMRAMLIPLVTIPLSLIGSMFFMLSMGFSINLLTLLAMVLAISLVVD 399
Cdd:COG0841   321 DQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGIVVD 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  400 DAIVVVENTFRHLEDGTSPIKAAIDSAREIAGSVIAMTITLAAVYAPIGFMGGLTGKLFTEFAFTLAGSVLISGFIALTL 479
Cdd:COG0841   401 DAIVVVENIERHMEEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFALTVAIALLISLFVALTL 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  480 TPMMCSKLLNKSVLD--GKLVKKIDAVIEGVTERYRKVLEHVLNNRVYIWPVVGTLLISLVFMFMNTSSELAPEEDQGVM 557
Cdd:COG0841   481 TPALCARLLKPHPKGkkGRFFRAFNRGFDRLTRGYGRLLRWALRHRKLTLLVALALLALSVLLFGRLPTEFFPEEDQGQI 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  558 IVMGQGPAQANTDYIRHFTPALIDSISKNDEVEMTMLDNGYMN-----NNAFFGLgVLKDWDSRDATAKEVMQRFEKESS 632
Cdd:COG0841   561 IVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSGggsgsNSGTIFV-TLKPWDERDRSADEIIARLREKLA 639
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  633 VLPGLQVYTFSPPDlPGTPQGLPFQMVLKTPtgSYQDLYQYAEKLKEYAQKSGKFIYVQNDLNFNKPQVEIRIDRDKAAQ 712
Cdd:COG0841   640 KIPGARVFVFQPPA-GGLGSGAPIEVQLQGD--DLEELAAAAEKLLAALRQIPGLVDVRSDLQLGKPELQLDIDREKAAA 716
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  713 MNVNAQDIGTVLSRFISEGFVNYFSMDQRSYQVITQVPNENRNSWDDLKNYHVRSNTNEMVPLASLIEISQSVQPSKVDQ 792
Cdd:COG0841   717 LGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYVRTPDGEMVPLSSVATIEEGTGPSSINR 796
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  793 FQQLNSAMIEAKMMPGISIGEAYKVMEEGAAKI-LPKSYTTDTSGQLRQFLQEGSSLVTTFFLALVIIYLVLAAQFESLR 871
Cdd:COG0841   797 YNGQRSVTVSANLAPGVSLGEALAAIEELAAELkLPPGVSIEFTGQAEEEQESFSSLGLAFLLALLLVYLVLAAQFESFI 876
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  872 DPLVVLTSVPLSIFGALMPLYLGIDTLNIYTEVGLVTLIGLISKHGILIVEFANQMQQELKcSRREAAIRSATVRMRPVL 951
Cdd:COG0841   877 QPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFANQLREEGM-SLREAILEAARLRLRPIL 955
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 937073987  952 MTTAAMVVGVVPLLIASGAGAQSRFSIGLVITVGMSVGTLFTLFVVPTIYTYLAADHR 1009
Cdd:COG0841   956 MTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLLDRLRR 1013
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
3-1001 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 785.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987     3 FTDVFIKRPVLATVLSLVLLVLGLKAFTSLQVRQYPEIETGVITITTSYPGASASSVQGYVTQPLQAEIAQTAGIDYMTS 82
Cdd:pfam00873    1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987    83 DSALGKSVITVYLKLGYPSDSALTEILSLVQQVKYKLPSGVLDPSILK-STSQSPILYVSFSSD--TLKTEQVSDYVSRV 159
Cdd:pfam00873   81 QSSYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGVQRPGISViKTSLGPIMVLAVTSPdgSYTQTDLRDYADTN 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   160 VKPTFSTVEGVSKVDILGQEDFAMRIWLNPQRLASYGLTAEDVQNALRANNIVSAAGKLQNPYIEVDINAHTDSSSVDDF 239
Cdd:pfam00873  161 IKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAEDF 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   240 KNMALKAHDGQLVHLKDVATVELGAANYDSDVEFNGVTTVSTAISNTATSNPLTVVEGIYELLPQIQAGLPEGIKADVIY 319
Cdd:pfam00873  241 EKIIVKNQDGSPVRLRDVATVELGSELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQGVEIVVVY 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   320 DSTKFIETSIDEVAKTLIEAALIVVIVIFAFLGSMRAMLIPLVTIPLSLIGSMFFMLSMGFSINLLTLLAMVLAISLVVD 399
Cdd:pfam00873  321 DTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLAIGLVVD 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   400 DAIVVVENTFRHL-EDGTSPIKAAIDSAREIAGSVIAMTITLAAVYAPIGFMGGLTGKLFTEFAFTLAGSVLISGFIALT 478
Cdd:pfam00873  401 DAIVVVENIERVLeENGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIVLAILLSVLVALT 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   479 LTPMMCSKLLNKSVL--DGKLVKKIDAVIEGVTERYRKVLEHVLNNRVYIWPVVGTLLISLVFMFMNTSSELAPEEDQGV 556
Cdd:pfam00873  481 LTPALCATLLKPRREpkHGGFFRWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWLFVRIPTEFLPEEDEGV 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   557 MIVMGQGPAQANTDYIRHFTPALIDSISKNDEVEMTMLDNGY----MNNNAFFGLG--VLKDWDSRDA---TAKEVMQRF 627
Cdd:pfam00873  561 FVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFafsgDNNGPNSGDAfiSLKPWKERPGpekSVQALIERL 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   628 EKESSVLPGLQVYTFSPPDL--PGTPQGLPFQMVLKTPTGSYQDLYQYAEKLKEYAQKSGKFIYVQNDLNFNKPQVEIRI 705
Cdd:pfam00873  641 RKALKQIPGANVFLFQPIQLrgLGTISGFRSDLQVKIFGDDLDALDEARNQILAALAQLPGLSDVRSDGQEDQPQLQVNI 720
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   706 DRDKAAQMNVNAQDIGTVLSRFISEGFVNYFSMDQRSYQVITQVPNENRNSWDDLKNYHVRSNTNEMVPLASLIEISQSV 785
Cdd:pfam00873  721 DREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNPYGKMIPLSAFAKIEWGY 800
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   786 QPSKVDQFQQLNSAMIEAKMMPGISIGEAYKVMEEGAAKI-LPKSYTTDTSGQLRQFLQEGSSLVTTFFLALVIIYLVLA 864
Cdd:pfam00873  801 GPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVkLPPGYGYTWTGQFEQEQLAGNSLPILIALALLVVFLVLA 880
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   865 AQFESLRDPLVVLTSVPLSIFGALMPLYLGIDTLNIYTEVGLVTLIGLISKHGILIVEFANQMQQELKCSRREAAIRSAT 944
Cdd:pfam00873  881 ALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANELREQEGKSLEEAILEACR 960
                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 937073987   945 VRMRPVLMTTAAMVVGVVPLLIASGAGAQSRFSIGLVITVGMSVGTLFTLFVVPTIY 1001
Cdd:pfam00873  961 LRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPVFY 1017
2A0602 TIGR00915
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ...
3-1001 0e+00

The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]


Pssm-ID: 273335 [Multi-domain]  Cd Length: 1044  Bit Score: 653.34  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987     3 FTDVFIKRPVLATVLSLVLLVLGLKAFTSLQVRQYPEIETGVITITTSYPGASASSVQGYVTQPLQAEIAQTAGIDYMTS 82
Cdd:TIGR00915    1 MAKFFIDRPIFAWVIAIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987    83 DSA-LGKSVITVYLKLGYPSDSALTEILSLVQQVKYKLPSGVLDPSI-LKSTSQSPILYVSFSSD--TLKTEQVSDYVSR 158
Cdd:TIGR00915   81 SSDsDGSMTITLTFEQGTDPDIAQVQVQNKLQLATPLLPQEVQRQGVrVEKASSNFLMVIGLVSDdgSMTKEDLSDYAAS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   159 VVKPTFSTVEGVSKVDILGQEdFAMRIWLNPQRLASYGLTAEDVQNALRANNIVSAAGKL------QNPYIEVDINAHTD 232
Cdd:TIGR00915  161 NMVDPLSRLEGVGDVQLFGSQ-YAMRIWLDPAKLNSYQLTPADVISAISAQNAQISAGQLgglpavPGQQLNATIIAQTR 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   233 SSSVDDFKNMALKAH-DGQLVHLKDVATVELGAANYDSDVEFNGVTTVSTAISNTATSNPLTVVEGIYELLPQIQAGLPE 311
Cdd:TIGR00915  240 LQTPEQFENILLKVNtDGSQVRLKDVARVELGGENYSISARFNGKPASGLAIKLATGANALDTAKAVKAELAVLEPFFPQ 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   312 GIKADVIYDSTKFIETSIDEVAKTLIEAALIVVIVIFAFLGSMRAMLIPLVTIPLSLIGSMFFMLSMGFSINLLTLLAMV 391
Cdd:TIGR00915  320 GMKYVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAMV 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   392 LAISLVVDDAIVVVENTFRHL-EDGTSPIKAAIDSAREIAGSVIAMTITLAAVYAPIGFMGGLTGKLFTEFAFTLAGSVL 470
Cdd:TIGR00915  400 LAIGLLVDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMA 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   471 ISGFIALTLTPMMCSKLL------NKSVLDGKLVKKIDAVIEGVTERYRKVLEHVLNNRVYIWPVVGTLLISLVFMFMNT 544
Cdd:TIGR00915  480 LSVLVALILTPALCATMLkpiekgEHHEKKGGFFGWFNRMFDSSTHGYENGVGKILRRRGRYLLVYVLLVGGMVFLFVRL 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   545 SSELAPEEDQGVMIVMGQGPAQANTDYirhfTPALIDSISK------NDEVEMTMLDNGYM----NNNAFFGLGVLKDWD 614
Cdd:TIGR00915  560 PTSFLPDEDQGVFMTIVQLPAGATAER----TQAVLAQVTKyllakeKANVESVFTVNGFSfagrGQNMGMAFIRLKDWE 635
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   615 SRDA---TAKEVMQRFEKESSVLPGLQVYTFSPPDLPGTPQGLPFQMVLKTPTGSYQD-LYQYAEKLKEYAQKSGKFIYV 690
Cdd:TIGR00915  636 ERTGkenSVFAIAGRATGHFMQIKDAMVIAFVPPAILELGNATGFDFFLQDRAGLGHEaLLQARNQLLGLAAQNPALTRV 715
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   691 QNDLNFNKPQVEIRIDRDKAAQMNVNAQDIGTVLSRFISEGFVNYFSMDQRSYQVITQVPNENRNSWDDLKNYHVRSNTN 770
Cdd:TIGR00915  716 RPNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINKWYVRNASG 795
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   771 EMVPLASLIEISQSVQPSKVDQFQQLNSAMIEAKMMPGISIGEAYKVMEEGAAKiLPKSYTTDTSGQLRQFLQEGSSLVT 850
Cdd:TIGR00915  796 EMVPFSAFATVRWEYGSPQLERYNGLPSMEILGSAAPGVSTGQAMAAMEAIAQK-LPPGFGFSWTGMSYEERLSGSQAPA 874
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   851 TFFLALVIIYLVLAAQFESLRDPLVVLTSVPLSIFGALMPLYLGIDTLNIYTEVGLVTLIGLISKHGILIVEFANQMQQE 930
Cdd:TIGR00915  875 LYALSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLATTLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFAKELMAQ 954
                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 937073987   931 LKcSRREAAIRSATVRMRPVLMTTAAMVVGVVPLLIASGAGAQSRFSIGLVITVGMSVGTLFTLFVVPTIY 1001
Cdd:TIGR00915  955 GK-SIVEAALEAARLRLRPILMTSLAFILGVVPLAISTGAGSGSQHAIGTGVFGGMVTATVLAIFFVPLFY 1024
PRK09577 PRK09577
multidrug efflux RND transporter permease subunit;
7-1001 1.30e-173

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169981 [Multi-domain]  Cd Length: 1032  Bit Score: 534.43  E-value: 1.30e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987    7 FIKRPVLATVLSLVLLVLGLKAFTSLQVRQYPEIETGVITITTSYPGASASSVQGYVTQPLQAEIAQTAGIDYMTSDSAL 86
Cdd:PRK09577    5 FIDRPVFAWVISLFIMLGGIFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNGAPGLLYTSATSSA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   87 GKSVITVYLKLGYPSDSALTEILSLVQQVKYKLPSGVLDPSILKSTSQSPI-LYVSFSSDTLKTE--QVSDYVSRVVKPT 163
Cdd:PRK09577   85 GQASLSLTFKQGVNADLAAVEVQNRLKTVEARLPEPVRRDGIQVEKAADNIqLIVSLTSDDGRLTgvELGEYASANVLQA 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  164 FSTVEGVSKVDILGQEdFAMRIWLNPQRLASYGLTAEDVQNALRANNIVSAAGKL------QNPYIEVDINAHTDSSSVD 237
Cdd:PRK09577  165 LRRVEGVGKVQFWGAE-YAMRIWPDPVKLAALGLTASDIASAVRAHNARVTIGDIgrsavpDSAPIAATVFADAPLKTPE 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  238 DFKNMALKAH-DGQLVHLKDVATVELGAANYDSDVEFNGVTTVSTAISNTATSNPLTVVEGIYELLPQIQAGLPEGIKAD 316
Cdd:PRK09577  244 DFGAIALRARaDGSALYLRDVARIEFGGNDYNYPSYVNGKTATGMGIKLAPGSNAVATEKRVRATMDELSRYFPPGVKYQ 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  317 VIYDSTKFIETSIDEVAKTLIEAALIVVIVIFAFLGSMRAMLIPLVTIPLSLIGSMFFMLSMGFSINLLTLLAMVLAISL 396
Cdd:PRK09577  324 IPYETSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNFRATLIPTLVVPVALLGTFGVMLAAGFSINVLTMFGMVLAIGI 403
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  397 VVDDAIVVVENTFRHL-EDGTSPIKAAIDSAREIAGSVIAMTITLAAVYAPIGFMGGLTGKLFTEFAFTLAGSVLISGFI 475
Cdd:PRK09577  404 LVDDAIVVVENVERLMvEEGLSPYDATVKAMKQISGAIVGITVVLTSVFVPMAFFGGAVGNIYRQFALSLAVSIGFSAFL 483
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  476 ALTLTPMMCSKLLnKSVLDGKLVKK-----IDAVIEGVTERYRKVLEHVLNNRVYIWPVVGTLLISLVFMFMNTSSELAP 550
Cdd:PRK09577  484 ALSLTPALCATLL-KPVDGDHHEKRgffgwFNRFVARSTQRYATRVGAILKRPLRWLVVYGALTAAAALLFTRLPTAFLP 562
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  551 EEDQG---VMIVMGQGPAQANTDYirhfTPALIDS-ISKNDEVEMTMLDNGYmnnnAFFGLG--------VLKDWDSRDA 618
Cdd:PRK09577  563 DEDQGnfmVMVIRPQGTPLAETMQ----SVREVESyLRRHEPVAYTFALGGF----NLYGEGpnggmifvTLKDWKERKA 634
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  619 TAKEV---MQRFEKESSVLPGLQVYTFSPPDLP--GTPQGLPFQMVLKTPTGsYQDLYQYAEKLKEYAQKSGkfiyVQND 693
Cdd:PRK09577  635 ARDHVqaiVARINERFAGTPNTTVFAMNSPALPdlGSTSGFDFRLQDRGGLG-YAAFVAAREQLLAEGAKDP----ALTD 709
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  694 LNF----NKPQVEIRIDRDKAAQMNVNAQDIGTVLSRFISEGFVNYFSMDQRSYQVITQVPNENRNSWDDLKNYHVRSNT 769
Cdd:PRK09577  710 LMFagtqDAPQLKLDIDRAKASALGVSMDEINTTLAVMFGSDYIGDFMHGSQVRRVIVQADGRHRLDPDDVKKLRVRNAQ 789
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  770 NEMVPLASLIEISQSVQPSKVDQFQQLNSAMIEAKMMPGISIGEAYKVMEEGAAKiLPKSYTTDTSGQLRQFLQEGSSLV 849
Cdd:PRK09577  790 GEMVPLAAFATLHWTLGPPQLTRYNGYPSFTINGSAAPGHSSGEAMAAIERIAAT-LPAGIGYAWSGQSFEERLSGAQAP 868
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  850 TTFFLALVIIYLVLAAQFESLRDPLVVLTSVPLSIFGALMPLYLGIDTLNIYTEVGLVTLIGLISKHGILIVEFANQMQQ 929
Cdd:PRK09577  869 MLFALSVLVVFLALAALYESWSIPFAVMLVVPLGVIGAVLGVTLRGMPNDIYFKVGLIATIGLSAKNAILIVEVAKDLVA 948
                         970       980       990      1000      1010      1020      1030
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 937073987  930 ElKCSRREAAIRSATVRMRPVLMTTAAMVVGVVPLLIASGAGAQSRFSIGLVITVGMSVGTLFTLFVVPTIY 1001
Cdd:PRK09577  949 Q-RMSLADAALEAARLRLRPIVMTSLAFGVGVLPLAFASGAASGAQIAIGTGVLGGVITATVLAVFLVPLFF 1019
PRK15127 PRK15127
multidrug efflux RND transporter permease subunit AcrB;
7-1001 1.50e-162

multidrug efflux RND transporter permease subunit AcrB;


Pssm-ID: 185081 [Multi-domain]  Cd Length: 1049  Bit Score: 505.98  E-value: 1.50e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987    7 FIKRPVLATVLSLVLLVLGLKAFTSLQVRQYPEIETGVITITTSYPGASASSVQGYVTQPLQAEIAQTAGIDYMTSDS-A 85
Cdd:PRK15127    5 FIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSdS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   86 LGKSVITVYLKLGYPSDSALTEILSLVQQVKYKLPSGVLDPSI-LKSTSQSPILYVSFSSD--TLKTEQVSDYVSRVVKP 162
Cdd:PRK15127   85 TGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVsVEKSSSSFLMVVGVINTdgTMTQEDISDYVAANMKD 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  163 TFSTVEGVSKVDILGQEdFAMRIWLNPQRLASYGLTAEDVQNALRANNIVSAAGKL------QNPYIEVDINAHTDSSSV 236
Cdd:PRK15127  165 PISRTSGVGDVQLFGSQ-YAMRIWMNPNELNKFQLTPVDVINAIKAQNAQVAAGQLggtppvKGQQLNASIIAQTRLTST 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  237 DDFKNMALKAH-DGQLVHLKDVATVELGAANYDSDVEFNGVTTVSTAISNTATSNPLTVVEGIYELLPQIQAGLPEGIKA 315
Cdd:PRK15127  244 EEFGKILLKVNqDGSRVRLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKI 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  316 DVIYDSTKFIETSIDEVAKTLIEAALIVVIVIFAFLGSMRAMLIPLVTIPLSLIGSMFFMLSMGFSINLLTLLAMVLAIS 395
Cdd:PRK15127  324 VYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIG 403
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  396 LVVDDAIVVVENTFRHL-EDGTSPIKAAIDSAREIAGSVIAMTITLAAVYAPIGFMGGLTGKLFTEFAFTLAGSVLISGF 474
Cdd:PRK15127  404 LLVDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVL 483
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  475 IALTLTPMMCSKLLnKSVLDGKLVKK-------IDAVIEGVTERYRKVLEHVLNNR-----VYIWPVVGtllisLVFMFM 542
Cdd:PRK15127  484 VALILTPALCATML-KPIAKGDHGEGkkgffgwFNRMFEKSTHHYTDSVGNILRSTgrylvLYLIIVVG-----MAYLFV 557
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  543 NTSSELAPEEDQGVMIVMGQGPAQANTDYirhfTPALIDSIS------KNDEVEMTMLDNGY----MNNNAFFGLGVLKD 612
Cdd:PRK15127  558 RLPSSFLPDEDQGVFLTMVQLPAGATQER----TQKVLNEVTdyyltkEKNNVESVFAVNGFgfagRGQNTGIAFVSLKD 633
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  613 WDSR-------DATAKEVMQRFEKESSVLpglqVYTFSPPDLP--GTPQGLPFQMVLKTPTGSYQDLYQYAEKLKEYAQK 683
Cdd:PRK15127  634 WADRpgeenkvEAITMRATRAFSQIKDAM----VFAFNLPAIVelGTATGFDFELIDQAGLGHEKLTQARNQLLGEAAKH 709
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  684 SGKFIYVQNDLNFNKPQVEIRIDRDKAAQMNVNAQDIGTVLSRFISEGFVNYFSMDQRSYQVITQVPNENRNSWDDLKNY 763
Cdd:PRK15127  710 PDMLVGVRPNGLEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDW 789
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  764 HVRSNTNEMVPLASLIEISQSVQPSKVDQFQQLNSAMIEAKMMPGISIGEAYKVMEEGAAKiLPKSYTTDTSGQLRQFLQ 843
Cdd:PRK15127  790 YVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEELASK-LPTGVGYDWTGMSYQERL 868
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  844 EGSSLVTTFFLALVIIYLVLAAQFESLRDPLVVLTSVPLSIFGALMPLYLGIDTLNIYTEVGLVTLIGLISKHGILIVEF 923
Cdd:PRK15127  869 SGNQAPALYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEF 948
                         970       980       990      1000      1010      1020      1030
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 937073987  924 ANQMQQELKCSRREAAIRSATVRMRPVLMTTAAMVVGVVPLLIASGAGAQSRFSIGLVITVGMSVGTLFTLFVVPTIY 1001
Cdd:PRK15127  949 AKDLMDKEGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVFF 1026
PRK10555 PRK10555
multidrug efflux RND transporter permease AcrD;
7-1001 3.04e-161

multidrug efflux RND transporter permease AcrD;


Pssm-ID: 182544 [Multi-domain]  Cd Length: 1037  Bit Score: 502.44  E-value: 3.04e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987    7 FIKRPVLATVLSLVLLVLGLKAFTSLQVRQYPEIETGVITITTSYPGASASSVQGYVTQPLQAEIAQTAGIDYMTSDS-A 85
Cdd:PRK10555    5 FIDRPIFAWVLAILLCLTGTLAIFSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSsG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   86 LGKSVITVYLKLGYPSDSALTEILSLVQQVKYKLPSGVLDPSI-LKSTSQSPILYVSF-SSD-TLKTEQVSDYVSRVVKP 162
Cdd:PRK10555   85 TGQASVTLSFKAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVtVRKTGDTNILTIAFvSTDgSMDKQDIADYVASNIQD 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  163 TFSTVEGVSKVDILGQEdFAMRIWLNPQRLASYGLTAEDVQNALRANNIVSAAGKL------QNPYIEVDINAHTDSSSV 236
Cdd:PRK10555  165 PLSRVNGVGDIDAYGSQ-YSMRIWLDPAKLNSFQMTTKDVTDAIESQNAQIAVGQLggtpsvDKQALNATINAQSLLQTP 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  237 DDFKNMALKAH-DGQLVHLKDVATVELGAANYDSDVEFNGVTTVSTAISNTATSNPLTVVEGIYELLPQIQAGLPEGIKA 315
Cdd:PRK10555  244 EQFRDITLRVNqDGSEVTLGDVATVELGAEKYDYLSRFNGKPASGLGVKLASGANEMATAKLVLNRLDELAQYFPHGLEY 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  316 DVIYDSTKFIETSIDEVAKTLIEAALIVVIVIFAFLGSMRAMLIPLVTIPLSLIGSMFFMLSMGFSINLLTLLAMVLAIS 395
Cdd:PRK10555  324 KVAYETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSINTLTMFAMVLAIG 403
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  396 LVVDDAIVVVENTFRHL-EDGTSPIKAAIDSAREIAGSVIAMTITLAAVYAPIGFMGGLTGKLFTEFAFTLAGSVLISGF 474
Cdd:PRK10555  404 LLVDDAIVVVENVERIMsEEGLTPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVSAMVLSVL 483
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  475 IALTLTPMMCSKLLnKSVLDGKLVKK------IDAVIEGVTERYRKVLEHVLNNRVYiWPVVGTLLIS-LVFMFMNTSSE 547
Cdd:PRK10555  484 VAMILTPALCATLL-KPLKKGEHHGQkgffgwFNRMFNRNAERYEKGVAKILHRSLR-WILIYVLLLGgMVFLFLRLPTS 561
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  548 LAPEEDQGVMIVMGQGPAQAntdyirhftpALIDSISKNDEVEMTMLDNGYMNNNAFF----------GLGV------LK 611
Cdd:PRK10555  562 FLPLEDRGMFTTSVQLPSGS----------TQQQTLKVVEKVEKYYFTHEKDNVMSVFatvgsgpggnGQNVarmfirLK 631
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  612 DWDSRDA---TAKEVMQRFEKESSVLPGLQVYTFSPPDLPGTPQGLPFQMVLKTPTGSYQD-LYQYAEKLKEYAQKSGKF 687
Cdd:PRK10555  632 DWDERDSktgTSFAIIERATKAFNKIKEARVIASSPPAISGLGSSAGFDMELQDHAGAGHDaLMAARNQLLALAAKNPEL 711
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  688 IYVQNDLNFNKPQVEIRIDRDKAAQMNVNAQDIGTVLSRFISEGFVNYFSMDQRSYQVITQVPNENRNSWDDLKNYHVRS 767
Cdd:PRK10555  712 TRVRHNGLDDSPQLQIDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAPYRMLPDDINLWYVRN 791
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  768 NTNEMVPLASLIEISQSVQPSKVDQFQQLNSAMIEAKMMPGISIGEAYKVMEEGAAKiLPKSYTTDTSGQLRQFLQEGSS 847
Cdd:PRK10555  792 KDGGMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGVSTGTAMDIMESLVKQ-LPNGFGLEWTAMSYQERLSGAQ 870
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  848 LVTTFFLALVIIYLVLAAQFESLRDPLVVLTSVPLSIFGALMPLYL-GIDTlNIYTEVGLVTLIGLISKHGILIVEFANQ 926
Cdd:PRK10555  871 APALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMrGLEN-DVYFQVGLLTVIGLSAKNAILIVEFANE 949
                         970       980       990      1000      1010      1020      1030
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 937073987  927 MQQELKcSRREAAIRSATVRMRPVLMTTAAMVVGVVPLLIASGAGAQSRFSIGLVITVGMSVGTLFTLFVVPTIY 1001
Cdd:PRK10555  950 MNQKGH-DLFEATLHASRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQHAVGTGVMGGMISATILAIFFVPLFF 1023
PRK10503 PRK10503
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
7-1001 6.77e-147

MdtB/MuxB family multidrug efflux RND transporter permease subunit;


Pssm-ID: 182501 [Multi-domain]  Cd Length: 1040  Bit Score: 464.59  E-value: 6.77e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987    7 FIKRPVLATVLSLVLLVLGLKAFTSLQVRQYPEIETGVITITTSYPGASASSVQGYVTQPLQAEIAQTAGIDYMTSDSAL 86
Cdd:PRK10503   16 FILRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSG 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   87 GKSVITVYLKLGYPSDSALTEILSLVQQVKYKLPSGVLDPSILKSTSQS--PILYVSFSSDTLKTEQVSDYVSRVVKPTF 164
Cdd:PRK10503   96 GASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPAdpPIMTLAVTSTAMPMTQVEDMVETRVAQKI 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  165 STVEGVSKVDILGQEDFAMRIWLNPQRLASYGLTAEDVQNALRANNIVSAAGKLQNPYIEVDINAHTDSSSVDDFKNMAL 244
Cdd:PRK10503  176 SQVSGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPTRAVTLSANDQMQSAEEYRQLII 255
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  245 KAHDGQLVHLKDVATVELGAANYDSDVEFNGVTTVSTAISNTATSNPLTVVEGIYELLPQIQAGLPEGIKADVIYDSTKF 324
Cdd:PRK10503  256 AYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIATADSIRQMLPQLTESLPKSVKVTVLSDRTTN 335
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  325 IETSIDEVAKTLIEAALIVVIVIFAFLGSMRAMLIPLVTIPLSLIGSMFFMLSMGFSINLLTLLAMVLAISLVVDDAIVV 404
Cdd:PRK10503  336 IRASVDDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVV 415
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  405 VENTFRHLEDGTSPIKAAIDSAREIAGSVIAMTITLAAVYAPIGFMGGLTGKLFTEFAFTLAGSVLISGFIALTLTPMMC 484
Cdd:PRK10503  416 IENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILISAVVSLTLTPMMC 495
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  485 SKLLNKSVL--DGKLVKKIDAVIEGVTERYRKVLEHVLNN-RVYIWPVVGTLLISlVFMFMNTSSELAPEEDQGVMIVMG 561
Cdd:PRK10503  496 ARMLSQESLrkQNRFSRASERMFDRVIAAYGRGLAKVLNHpWLTLSVALSTLLLT-VLLWIFIPKGFFPVQDNGIIQGTL 574
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  562 QGPAQANTDYIRHFTPALIDSISKNDEVEMTMLDNGYMNNNAFFGLG----VLKDWDSRDATAKEVMQRFEKESSVLPGL 637
Cdd:PRK10503  575 QAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSArlqiNLKPLDERDDRVQKVIARLQTAVAKVPGV 654
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  638 QVYTFSPPDLPGTPQGLPFQMVLKTPTGSYQDLYQYAEKLKEYAQKSGKFIYVQNDLNFNKPQVEIRIDRDKAAQMNVNA 717
Cdd:PRK10503  655 DLYLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPKLMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISM 734
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  718 QDIGTVLSRFISEGFVNYFSMDQRSYQVITQVPNENRNSWDDLKNYHVRSNTNEMVPLASLIEISQSVQPSKVDQFQQLN 797
Cdd:PRK10503  735 ADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIATIEQRFGPLSINHLDQFP 814
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  798 SAMIEAKMMPGISIGEAYKVMEEGAAKI-LPKSYTTDTSGQLRQFLQEGSSLVTTFFLALVIIYLVLAAQFESLRDPLVV 876
Cdd:PRK10503  815 STTISFNVPDGYSLGDAVQAIMDTEKTLnLPADITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGVLYESFIHPITI 894
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  877 LTSVPLSIFGALMPLYLGIDTLNIYTEVGLVTLIGLISKHGILIVEFANQMQQELKCSRREAAIRSATVRMRPVLMTTAA 956
Cdd:PRK10503  895 LSTLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIYQACLLRFRPILMTTLA 974
                         970       980       990      1000
                  ....*....|....*....|....*....|....*....|....*
gi 937073987  957 MVVGVVPLLIASGAGAQSRFSIGLVITVGMSVGTLFTLFVVPTIY 1001
Cdd:PRK10503  975 ALLGALPLMLSTGVGAELRRPLGICMVGGLIVSQVLTLFTTPVIY 1019
CusA COG3696
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
28-1001 7.50e-143

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];


Pssm-ID: 442911 [Multi-domain]  Cd Length: 1031  Bit Score: 453.72  E-value: 7.50e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   28 AFTSLQVRQYPEIETGVITITTSYPGASASSVQGYVTQPLQAEIAQTAGIDYMTSDSALGKSVITVYLKLGYPSDSALTE 107
Cdd:COG3696    30 SLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVKEVRSISRFGLSVVTVIFEDGTDIYWARQL 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  108 ILSLVQQVKYKLPSGVlDPSILK-STSQSPILYVSFSSDT-------LKTEQvsDYVsrvVKPTFSTVEGVSKVDILGQE 179
Cdd:COG3696   110 VLERLQQVREQLPAGV-TPELGPiSTGLGEIYQYTLESDPgkyslmeLRTLQ--DWV---IRPQLRSVPGVAEVNSFGGF 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  180 DFAMRIWLNPQRLASYGLTAEDVQNALRANNIVSAAGKLQNPYIEVDINAHTDSSSVDDFKNMALKAHDGQLVHLKDVAT 259
Cdd:COG3696   184 VKQYQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERGGQEYLVRGIGLIRSLEDIENIVVKTRNGTPVLLRDVAE 263
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  260 VELGAANYDSDVEFNGVT-TVSTAISNTATSNPLTVVEGIYELLPQIQAGLPEGIKADVIYDSTKFIETSIDEVAKTLIE 338
Cdd:COG3696   264 VRIGPAPRRGAATLNGEGeVVGGIVLMLKGENALEVIEAVKAKLAELKPSLPEGVKIVPFYDRSDLIDRAIHTVTKNLLE 343
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  339 AALIVVIVIFAFLGSMRAMLIPLVTIPLSLIGSMFFMLSMGFSINLLTLLAMVLAISLVVDDAIVVVENTFRHLE----- 413
Cdd:COG3696   344 GALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGGLAIDFGIIVDGAVVMVENILRRLEenraa 423
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  414 -DGTSPIKAAIDSAREIAGSVIAMTITLAAVYAPIGFMGGLTGKLFTEFAFTLAGSVLISGFIALTLTPMMCSKLLNksv 492
Cdd:COG3696   424 gTPRERLEVVLEAAREVRRPIFFATLIIILVFLPIFTLEGVEGKLFRPMALTVIFALLGALLLSLTLVPVLASLLLR--- 500
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  493 ldGKLVKKIDAVIEGVTERYRKVLEHVLNNRVYIWPVVGTLLISLVFMFMNTSSELAPEEDQGVMIVMGQGPAQANTDYI 572
Cdd:COG3696   501 --GKVPEKENPLVRWLKRLYRPLLRWALRHPKLVLAVALVLLVLALALFPRLGSEFLPELDEGDLLVMATLPPGISLEES 578
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  573 RHFTPALIDSISKNDEVEMTM---------LDNGYMNNNAFF-GLGVLKDWdSRDATAKEVMQRFEKESSVLPGLqVYTF 642
Cdd:COG3696   579 VELGQQVERILKSFPEVESVVsrtgraedaTDPMGVNMSETFvILKPRSEW-RSGRTKEELIAEMREALEQIPGV-NFNF 656
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  643 SPP--DLpgtpqglpFQMVLktpTGSYQD------------LYQYAEKLKEYAQK-----SgkfiyVQNDLNFNKPQVEI 703
Cdd:COG3696   657 SQPiqMR--------VDELL---SGVRADvavkifgddldvLRRLAEQIEAVLKTvpgaaD-----VQVERVTGLPQLDI 720
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  704 RIDRDKAAQMNVNAQDI---------GTVLSRFIsEGfvnyfsmdQRSYQVITQVPNENRNSWDDLKNYHVRSNTNEMVP 774
Cdd:COG3696   721 RIDRDAAARYGLNVADVqdvvetaigGKAVGQVY-EG--------ERRFDIVVRLPEELRDDPEAIRNLPIPTPSGAQVP 791
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  775 LASLIEISQSVQPSKVDQFQQLNSAMIEAKMMpGISIGEaykVMEEGAAKI-----LPKSYTTDTSGQLRQFLQEGSSLV 849
Cdd:COG3696   792 LSQVADIEVVEGPNQISRENGRRRIVVQANVR-GRDLGS---FVAEAQAKVaeqvkLPPGYYIEWGGQFENLQRATARLA 867
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  850 TTFFLALVIIYLVLAAQFESLRDPLVVLTSVPLSIFGALMPLYLGIDTLNIYTEVGLVTLIGLISKHGILIVEFANQMQQ 929
Cdd:COG3696   868 IVVPLALLLIFLLLYLAFGSVRDALLILLNVPFALIGGVLALWLRGMPLSVSAGVGFIALFGVAVLNGVVLVSYINQLRA 947
                         970       980       990      1000      1010      1020      1030
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 937073987  930 ELKcSRREAAIRSATVRMRPVLMTTAAMVVGVVPLLIASGAGA--QSRFSIglVITVGMSVGTLFTLFVVPTIY 1001
Cdd:COG3696   948 EGL-DLREAIIEGALERLRPVLMTALVAALGLLPMALSTGPGSevQRPLAT--VVIGGLITSTLLTLLVLPALY 1018
PRK10614 PRK10614
multidrug efflux system subunit MdtC; Provisional
1-1004 1.30e-136

multidrug efflux system subunit MdtC; Provisional


Pssm-ID: 182589 [Multi-domain]  Cd Length: 1025  Bit Score: 436.85  E-value: 1.30e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987    1 MTFTDVFIKRPVLATVLSLVLLVLGLKAFTSLQVRQYPEIETGVITITTSYPGASASSVQGYVTQPLQAEIAQTAGIDYM 80
Cdd:PRK10614    1 MKFFALFIYRPVATILLSLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   81 TSDSALGKSVITVYLKLGYPSDSALTEILSLVQQVKYKLPSGVLD-PSILKST-SQSPILYVSFSSDTLKTEQVSDYVSR 158
Cdd:PRK10614   81 TSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSrPTYRKANpSDAPIMILTLTSDTYSQGQLYDFAST 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  159 VVKPTFSTVEGVSKVDILGQEDFAMRIWLNPQRLASYGLTAEDVQNALRANNIVSAAGKLQNPYIEVDINAHTDSSSVDD 238
Cdd:PRK10614  161 QLAQTISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRQAISNANVRRPQGAVEDGTHRWQIQTNDELKTAAE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  239 FKNMALKAHDGQLVHLKDVATVELGAANYDSDVEFNGVTTVSTAISNTATSNPLTVVEGIYELLPQIQAGLPEGIKADVI 318
Cdd:PRK10614  241 YQPLIIHYNNGAAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDRIRAKLPELRETIPAAIDLQIA 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  319 YDSTKFIETSIDEVAKTLIEAALIVVIVIFAFLGSMRAMLIPLVTIPLSLIGSMFFMLSMGFSINLLTLLAMVLAISLVV 398
Cdd:PRK10614  321 QDRSPTIRASLEEVEQTLAISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVV 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  399 DDAIVVVENTFRHLEDGTSPIKAAIDSAREIAGSVIAMTITLAAVYAPIGFMGGLTGKLFTEFAFTLAGSVLISGFIALT 478
Cdd:PRK10614  401 DDAIVVLENISRHLEAGMKPLQAALQGVREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLFREFAVTLSVAIGISLLVSLT 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  479 LTPMMCSKLLNKSVLDG-KLVKKIDAVIEGVTERYRKVLEHVLNN-RVYIWPVVGTLLISlVFMFMNTSSELAPEEDQGV 556
Cdd:PRK10614  481 LTPMMCAWLLKSSKPREqKRLRGFGRMLVALQQGYGRSLKWVLNHtRWVGVVLLGTIALN-VWLYISIPKTFFPEQDTGR 559
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  557 MivMGQGPA------QANTDYIRHFtpalIDSISKNDEVEMTMLDNGYMNNNAFFGLGVLKDWDSRDATAKEVMQRFEKE 630
Cdd:PRK10614  560 L--MGFIQAdqsisfQAMRGKLQDF----MKIIRDDPAVDNVTGFTGGSRVNSGMMFITLKPLSERSETAQQVIDRLRVK 633
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  631 SSVLPGLQVYTFSPPDLP--GTPQGLPFQMVLKtpTGSYQDLYQYAEKLKEYAQKSGKFIYVQNDLNFNKPQVEIRIDRD 708
Cdd:PRK10614  634 LAKEPGANLFLMAVQDIRvgGRQSNASYQYTLL--SDDLAALREWEPKIRKALAALPELADVNSDQQDKGAEMALTYDRD 711
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  709 KAAQMNVNAQDIGTVLS-----RFISegfVNYFSMDQrsYQVITQVPNENRNSWDDLKNYHVRSNTNEMVPLASLIEISQ 783
Cdd:PRK10614  712 TMARLGIDVQAANSLLNnafgqRQIS---TIYQPLNQ--YKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQP 786
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  784 SVQPSKVDQfQQLNSA-MIEAKMMPGISIGEAYKVMEEGAAKI-LPKSYTTDTSGQLRQFLQEGSSLVTTFFLALVIIYL 861
Cdd:PRK10614  787 ANAPLSVNH-QGLSAAsTISFNLPTGKSLSDASAAIERAMTQLgVPSTVRGSFAGTAQVFQETMNSQLILILAAIATVYI 865
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  862 VLAAQFESLRDPLVVLTSVPLSIFGALMPLYLGIDTLNIYTEVGLVTLIGLISKHGILIVEFANQMQQELKCSRREAAIR 941
Cdd:PRK10614  866 VLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRNGNLTAQEAIFQ 945
                         970       980       990      1000      1010      1020
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 937073987  942 SATVRMRPVLMTTAAMVVGVVPLLIASGAGAQSRFSIGLVITVGMSVGTLFTLFVVPTIYTYL 1004
Cdd:PRK10614  946 ACLLRFRPIMMTTLAALFGALPLVLSGGDGAELRQPLGITIVGGLVMSQLLTLYTTPVVYLFF 1008
2A0601 TIGR00914
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ...
38-1012 3.06e-103

heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129992 [Multi-domain]  Cd Length: 1051  Bit Score: 347.52  E-value: 3.06e-103
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987    38 PEIETGVITITTSYPGASASSVQGYVTQPLQAEIAQTAGIDYMTSDSALGKSVITVYLKLGYPSDSALTEILSLVQQVKY 117
Cdd:TIGR00914   40 PDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLETTRSLSRYGLSQVTVIFKDGTDLYFARQLVNERLQQARD 119
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   118 KLPSGVLDPSILKSTSQSPILYVSF---SSDTLKTEQVSDYVSR------VVKPTFSTVEGVSKVDILGQEDFAMRIWLN 188
Cdd:TIGR00914  120 NLPEGVSPEMGPISTGLGEIFLYTVeaeEGARKKDGGAYTLTDLrtiqdwIIRPQLRTVPGVAEVNSIGGYVKQFLVAPD 199
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   189 PQRLASYGLTAEDVQNALRANNIVSAAGKLQNPYIEVDINAHTDSSSVDDFKNMALKAHDGQLVHLKDVATVELGAANYD 268
Cdd:TIGR00914  200 PEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRAPGQVQSMDDIRNIVIATGEGVPIRIRDVARVQIGKELRT 279
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   269 SDVEFNGVTTVSTAISNTATSNPLTVVEGIYELLPQIQAGLPEGIKADVIYDSTKFIETSIDEVAKTLIEAALIVVIVIF 348
Cdd:TIGR00914  280 GAATENGKEVVLGTVFMLIGENSRTVAQAVGDKLETINKTLPEGVEIVTTYDRSQLVDAAIATVKKNLLEGALLVIVILF 359
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   349 AFLGSMRAMLIPLVTIPLSLIGSMFFMLSMGFSINLLTLLAmvLAISLVVDDAIVVVENTFRHLE----------DGTSP 418
Cdd:TIGR00914  360 LFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSLGA--LDFGLIVDGAVVIVENAHRRLAeaqhhhgrqlTLKER 437
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   419 IKAAIDSAREIAGSVIAMTITLAAVYAPIGFMGGLTGKLFTEFAFTLAGSVLISGFIALTLTPMMCSKLLNksvldGKLV 498
Cdd:TIGR00914  438 LHEVFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGKMFHPMAFTVVLALAGAMILSLTFVPAAVALFIR-----GKVA 512
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   499 KKIDAVIEGVTERYRKVLEHVLNNRVYIWPVVGTLLISLVFMFMNTSSELAPEEDQGVMIVM-----GQGPAQANTdyIR 573
Cdd:TIGR00914  513 EKENRLMRVLKRRYEPLLERVLAWPAVVLGAAAVSIVLVVWIASRVGGEFIPSLNEGDLAYQalripGTSLAQSVA--MQ 590
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   574 HFTPALIDSISkndEVEMTMLDNGY-------MNNNAFFGLGVLK---DWDSRDATAKEVMQRFEKESSVLPGLqVYTFS 643
Cdd:TIGR00914  591 QTLEKLIKSFP---EVARVFAKTGTaeiatdpMPPNASDTYIILKpesQWPEGKKTKEDLIEEIQEATVRIPGN-NYEFT 666
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   644 PP------DLPGtpqGLPFQMVLKTPTGSYQDLYQYAEKLKEYAQKSGKFIYVQNDLNFNKPQVEIRIDRDKAAQMNVNA 717
Cdd:TIGR00914  667 QPiqmrfnELIS---GVRSDVAVKVFGDDLDDLDATAEKISAVLKGVPGAADVKVEQTTGLPYLTVEIDREKAARYGLTV 743
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   718 QDIGTVLSRFISEGFVNYFSMDQRSYQVITQVPNENRNSWDDLKNYHVRSNTNEM-----VPLASLIEISQSVQPSKVDQ 792
Cdd:TIGR00914  744 GDVQDTVATAVGGRMSGETFEGDRRFDIVIRLPESLRESPQALRQLPIPLPLSEDarkqfIPLSDVADLRVSPGPNQISR 823
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   793 FQQLNSAMIEAKMMpGISIGEaykVMEEGAAKI-----LPKSYTTDTSGQLRQFLQEGSSLVTTFFLALVIIYLVLAAQF 867
Cdd:TIGR00914  824 ENGKRRVVVSANVR-GRDLGS---FVDDAKKAIaeqvkLPPGYWITWGGQFEQLQSATKRLQIVVPVTLLLIFVLLYAAF 899
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   868 ESLRDPLVVLTSVPLSIFGALMPLYLGIDTLNIYTEVGLVTLIGLISKHGILIVEFANQMQQELKcSRREAAIRSATVRM 947
Cdd:TIGR00914  900 GNVKDALLVFTGIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNGLVMISFIRKLLEEGP-SLDEAVYEGALTRV 978
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 937073987   948 RPVLMTTAAMVVGVVPLLIASGAGAQSRFSIGLVITVGMSVGTLFTLFVVPTIY-TYLAADHRGQE 1012
Cdd:TIGR00914  979 RPVLMTALVASLGFVPMAIATGTGAEVQRPLATVVIGGIITATLLTLFVLPALYrLVHRRRHKGRK 1044
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
280-1000 9.77e-23

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 104.56  E-value: 9.77e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  280 STAISNTATSNPLTVVEGIYELLPQIQAGL----PEGIKADVI---YDSTKFIETSIDEVAKTLIEAALIVVIVIFAFLG 352
Cdd:COG1033   161 ATLIVVTLDPDPLSSDLDRKEVVAEIRAIIakyeDPGVEVYLTgfpVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFR 240
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  353 SMRAMLIPLVTIPLSLIGSMFFMLSMGFSINLLTLLAMVLAISLVVDDAIVVVENTFRHLEDGTSPIKAAIDSAREIAGS 432
Cdd:COG1033   241 SLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYREERRKGLDKREALREALRKLGPP 320
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  433 VIAMTITLAavyapIGFMGGLTGKL--FTEFAFTLAGSVLISGFIALTLTPMMcskllnKSVLDGKLVKKIDAVIEGVTE 510
Cdd:COG1033   321 VLLTSLTTA-----IGFLSLLFSDIppIRDFGIVAAIGVLLAFLTSLTLLPAL------LSLLPRPKPKTRRLKKPPELG 389
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  511 RYRKVLEH-VLNNRVYIwpVVGTLLISLVFMFMntSSELAPEEDQgvmivmgqgpaqanTDYIRHFTPALIDSISKNDEV 589
Cdd:COG1033   390 RLLAKLARfVLRRPKVI--LVVALVLAVVSLYG--ISRLKVEYDF--------------EDYLPEDSPIRQDLDFIEENF 451
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  590 EMTMldngymnnNAFFGLGVLKDWDSRDATAKEVMQRFEKESSVLPGLQvYTFSPPDLpgtpqglpfqmvlktptgsyqd 669
Cdd:COG1033   452 GGSD--------PLEVVVDTGEPDGLKDPEVLKEIDRLQDYLESLPEVG-KVLSLADL---------------------- 500
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  670 lyqyaekLKEYAQksgkfIYVQNDLNFNkpqvEIRIDRDKAAQ-MNVNAQDIGTVLSRFISEgfvnyfsmDQRSYQVITQ 748
Cdd:COG1033   501 -------VKELNQ-----ALNEGDPKYY----ALPESRELLAQlLLLLSSPPGDDLSRFVDE--------DYSAARVTVR 556
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  749 VPNenrnswddlknyhvrSNTNEMVPLASLIE-ISQSVQPSKVDQFQQLNSAMIEAKMMPGISigeaykvmeegaakilp 827
Cdd:COG1033   557 LKD---------------LDSEEIKALVEEVRaFLAENFPPDGVEVTLTGSAVLFAAINESVI----------------- 604
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  828 ksyttdtsgqlrqflqegSSLVTTFFLALVIIYLVLAAQFESLRDPLVVLTS--VPLSIFGALMPlYLGIDtLNIYTEVG 905
Cdd:COG1033   605 ------------------ESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPnlLPILLTFGLMG-LLGIP-LNIATAVV 664
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  906 LVTLIGLISKHGILIVefaNQMQQELK--CSRREAAIRSATVRMRPVLMTTAAMVVGVVPLLIASGAGAQsrfSIGLVIT 983
Cdd:COG1033   665 ASIALGIGVDYTIHFL---SRYREERRkgGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLA---DFGLLLA 738
                         730
                  ....*....|....*..
gi 937073987  984 VGMSVGTLFTLFVVPTI 1000
Cdd:COG1033   739 LGLLVALLAALLLLPAL 755
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
329-487 2.06e-13

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 74.51  E-value: 2.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  329 IDEVAKTLIEAALIVVIVIFAFL----GSMRAMLIPLVTIPLSLIGSMFFMLSMGFSINLLTLLAMVLAISLVVDDAIVV 404
Cdd:COG1033   600 NESVIESQIRSLLLALLLIFLLLllafRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHF 679
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  405 VENTFRHLEDGTSPIKAAIDSAREIAGSVIAMTITLAAvyapiGFMGGLT--GKLFTEFAFTLAGSVLISGFIALTLTPM 482
Cdd:COG1033   680 LSRYREERRKGGDLEEAIRRALRTTGKAILFTSLTLAA-----GFGVLLFssFPPLADFGLLLALGLLVALLAALLLLPA 754

                  ....*
gi 937073987  483 MCSKL 487
Cdd:COG1033   755 LLLLL 759
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
840-1000 3.05e-10

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 64.09  E-value: 3.05e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   840 QFLQE-GSSLVTTFFLALVIIYLVLAAQFESLRDPLVVLtsvPLSIFGALMPL----YLGIdTLNIYTEVGLVTLIGLIS 914
Cdd:TIGR00921  186 DIEREfGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPL---VIILFGVAWVLgimgWLGI-PLYATTLLAVPMLIGVGI 261
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   915 KHGIlivEFANQMQQELKCSR--REAAIRSATVRMRPVLMTTAAMVVGVVPLLIaSGAGAQSRFSIGLVITVGMSVgtLF 992
Cdd:TIGR00921  262 DYGI---QTLNRYEEERDIGRakGEAIVTAVRRTGRAVLIALLTTSAGFAALAL-SEFPMVSEFGLGLVAGLITAY--LL 335

                   ....*...
gi 937073987   993 TLFVVPTI 1000
Cdd:TIGR00921  336 TLLVLPAL 343
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
300-540 1.24e-09

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 62.09  E-value: 1.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  300 ELLPQIQAGLPEGIKADV---IYDSTKFIETSIDEVAKTLIEAALIVVIVIFAFLGSMRAMLIPLVTIPLSLIGSM---- 372
Cdd:COG2409   136 ALRDAVAAAPAPGLTVYVtgpAALAADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALglla 215
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  373 ----FFMLSmGFSINLLTLLAMVLAIslvvDDAIVVVeNTFRH-LEDGTSPIKAAIDSAREiAGSVI---AMT--ITLAA 442
Cdd:COG2409   216 llaaFTDVS-SFAPNLLTMLGLGVGI----DYALFLV-SRYREeLRAGEDREEAVARAVAT-AGRAVlfsGLTvaIALLG 288
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  443 VY-APIGFmggltgklFTEFAFTLAGSVLISGFIALTLTPMMCSkLLNKSVLDGKlVKKIDAVIEGVTERYRKVLEHVLN 521
Cdd:COG2409   289 LLlAGLPF--------LRSMGPAAAIGVAVAVLAALTLLPALLA-LLGRRVFWPR-RPRRRRAAAPESGFWRRLARAVVR 358
                         250
                  ....*....|....*....
gi 937073987  522 NRVYIWpvVGTLLISLVFM 540
Cdd:COG2409   359 RPVPVL--VAAVAVLLALA 375
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
227-481 1.97e-09

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 60.38  E-value: 1.97e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   227 INAHTDSSSVDDFKNmALKAHDGQLVHLKDVATVELGAANYDSDvefNG--VTTVSTAISNTATSNPLTVVEGIYELLPQ 304
Cdd:pfam03176   40 LGDAAAEAGYDTLVD-ALRADTGHVGSVQDFWGDPDTAALFVSP---DGkaAYVVVTLEGDPGTTEADESVAAVRDAVEQ 115
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   305 IQAglPEGIKADVIYDSTKF--IETSIDEVAKTLIEAALIVVIVIFAFL-GSMRAMLIPLVTIPLSLIGS----MFFMLS 377
Cdd:pfam03176  116 APP--PEGLKAYLTGPAATVadLRDAGDRDLGLIEAVTLVVIFIILLIVyRSVVAALLPLLTVGLSLGAAqglvAILAHI 193
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   378 MGFSINLLTL-LAMVLAISLVVDDAIVVV----ENTFRHLEDGTSPIKAAIDSAREIAGSVIAMTITLAA-VYAPIGFMG 451
Cdd:pfam03176  194 LGIGLSTFALnLLVVLLIAVGTDYALFLVsryrEELRAGEDREEAVIRAVRGTGKVVTAAGLTVAIAMLAlSFARLPVFA 273
                          250       260       270
                   ....*....|....*....|....*....|
gi 937073987   452 GLtgklftefAFTLAGSVLISGFIALTLTP 481
Cdd:pfam03176  274 QV--------GPTIAIGVLVDVLAALTLLP 295
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
845-1004 3.15e-08

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 57.56  E-value: 3.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  845 GSSLVTTFFLALVIIYLVLAAQFESLRDPLVVLTSVPLSI---FGALmpLYLGIdTLNIYTEVGLVTLIGLISKHGI-LI 920
Cdd:COG1033   217 QSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAViwtLGLM--GLLGI-PLSPLTILVPPLLLAIGIDYGIhLL 293
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  921 VEFANQMQQELkcSRREAAIRSATVRMRPVLMTTAAMVVGVVPLLIA-SGAGAQsrfsIGLVITVGMSVGTLFTLFVVPT 999
Cdd:COG1033   294 NRYREERRKGL--DKREALREALRKLGPPVLLTSLTTAIGFLSLLFSdIPPIRD----FGIVAAIGVLLAFLTSLTLLPA 367

                  ....*
gi 937073987 1000 IYTYL 1004
Cdd:COG1033   368 LLSLL 372
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
306-1004 2.56e-06

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 51.51  E-value: 2.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   306 QAGLPEGIKADV------IYDSTKFIETSideVAKTLIEAALIVVIVIFAFLGSMRAMLIPLVTIPLSLIGSMFFMLSMG 379
Cdd:TIGR00833  146 QTNAPDGLTVHVtgplatIADILESGDKD---MNRITATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLG 222
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   380 ---------FSINLLTllamVLAISLVVDDAIVVVENTFRHLEDGTSPIKAAIDSAREIAGSVIAMTITLAAvyapiGFM 450
Cdd:TIGR00833  223 ipgligvnaQTTVLLT----ALVIGAGTDYAVFLTGRYHEERRKGESLEEAAAEALRGTGKAILGSALTVAV-----AFL 293
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   451 GGLTGKL--FTEFAFTLAGSVLISGFIALTLTPmmcsKLLNKSVLDGKLVKKIDAVIEGVTERyrkvlehvLNNRVYIWP 528
Cdd:TIGR00833  294 ALSLARLpsFKTLGVSCAVGVLVALLNAVTLTP----ALLTLEGREGLMKPGRKSKIRFIWRR--------LGTAVVRRP 361
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   529 ---VVGTLLISLVFMFmnTSSELAPEEDQGVMIVMGQGPAQANTDYIRHFTPALIDsiskndevEMTMLDNGymnnnaff 605
Cdd:TIGR00833  362 wpiLVTTLIISGVSLL--ALPLIRTGYDDEKMIPTDLESVQGYEAADRHFPGNSMD--------PMVVMIKS-------- 423
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   606 glgvlkDWDSRDATAKEVMQRFEKESSVLPGLQVY--TFSPPDLPGTPQGLPFQM---------VLKTPTGSYQDLYQYA 674
Cdd:TIGR00833  424 ------DHDVRNPALLADIDRFEREIKAVPGINMVqeTQRPDGVVIKKTYLTFQAgnlgdqldeFSDQLTSRQAYLLQDA 497
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   675 EKLKEYAQKSGKFIYVQNDLNFNKPQVEIRI-----DRDKAAQMNVNAQDIGTVLSRFISEGFVNYFSMDQRSYQVITQV 749
Cdd:TIGR00833  498 EKIAEAIAGLRLVQAGMRLDGENLGQVSLAVrlmqqAISKLQGSAGDVFDIFDPLRRFVAAIPECRANPVCSVAREIVQA 577
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   750 PNENRNSWDDLKN-YHVRSNTNEMVP------------LASLIEISQSVQPSKVDQFQQLNSAMIEAKMM-------PGI 809
Cdd:TIGR00833  578 ADTVVSSAAKLADaAGQLARGIADVAsalsqvsglpnaLDGIGTQLAQMRESAAGVQDLLNELSDYSMTMgklkgnaMGV 657
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   810 SIGEAYKVMEEGAAKILPKSYTTDTSGQLRQFLQE--------------------------------------------- 844
Cdd:TIGR00833  658 DFYAPPRIFTDPNFKAVLDYFLSPDGHAARLLVYGdgspagdqgaqefnairtvaeeaiqradlepakvelagvsavnrd 737
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   845 -----GSSLVTTFFLALVIIYLVLAAQFESLRDPLVVLTSVPLSIFGAL------MPLYLGIDTLNIYTEVGLVTLIGLI 913
Cdd:TIGR00833  738 lrdlvNSDLGLISIITLAIVFMILALLLRAPVAPIVLIGSVALSYLWALglsvlaFQHILGAELHWSVLAGVFVLLVALG 817
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   914 SKHGILIVefaNQMQQELKCSRREAAIRSatvrmrpvlMTTAAMVVGVVPLLIASG----AGAQSRF--SIGLVITVGMS 987
Cdd:TIGR00833  818 VDYNMLLV---SRIKEESPAGNRTGIIRA---------LGSTGGVITAAGLVFAGTmaalASAQLTAiaQFGFTVGVGIL 885
                          810
                   ....*....|....*..
gi 937073987   988 VGTLFTLFVVPTIYTYL 1004
Cdd:TIGR00833  886 LDTFIVRSVTVPALTLL 902
PRK10555 PRK10555
multidrug efflux RND transporter permease AcrD;
848-1011 2.46e-05

multidrug efflux RND transporter permease AcrD;


Pssm-ID: 182544 [Multi-domain]  Cd Length: 1037  Bit Score: 48.29  E-value: 2.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  848 LVTTFFLALVIIYLVLAAQFESLRDPLVVLTSVPLSIFGALMPLYLGIDTLNIYTEVGLVTLIGLISKHGILIVEFANQM 927
Cdd:PRK10555  340 VVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSINTLTMFAMVLAIGLLVDDAIVVVENVERI 419
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  928 QQELKCSRREAAiRSATVRMRPVLMTTAAMVVGV-VPLLIASG-AGAQSR-FSIGLVITVGMSVgtLFTLFVVPTI-YTY 1003
Cdd:PRK10555  420 MSEEGLTPREAT-RKSMGQIQGALVGIAMVLSAVfVPMAFFGGtTGAIYRqFSITIVSAMVLSV--LVAMILTPALcATL 496

                  ....*...
gi 937073987 1004 LAADHRGQ 1011
Cdd:PRK10555  497 LKPLKKGE 504
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
310-481 2.77e-04

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 44.83  E-value: 2.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   310 PEGIKADVIYD---STKFIETSIDEVAKTLIEAALIVVIVIFAFLGSMRAMLIPLVTIPLSLIGSMFFMLSMGFSINLLT 386
Cdd:TIGR00921  170 PSGKFLDVTGSpaiNYDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATT 249
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   387 LLAMVLAISLVVDDAIVVVENTFRHLEDGTSPIKAAIDSAREIAGSVIamtitLAAVYAPIGFMGGLTGKL--FTEFAFT 464
Cdd:TIGR00921  250 LLAVPMLIGVGIDYGIQTLNRYEEERDIGRAKGEAIVTAVRRTGRAVL-----IALLTTSAGFAALALSEFpmVSEFGLG 324
                          170
                   ....*....|....*..
gi 937073987   465 LAGSVLISGFIALTLTP 481
Cdd:TIGR00921  325 LVAGLITAYLLTLLVLP 341
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
326-481 3.50e-04

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 44.60  E-value: 3.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   326 ETSIDEVAKTLIEAALIVVIVIFAFLGSMRAMLIPLVTIPLSLIGSMFFMLSMGFSINLLTLLAMVLAISLVVDDAIVVV 405
Cdd:TIGR03480  265 ATVSEGATVAGLLSFVLVLVLLWLALRSPRLVFAVLVTLIVGLILTAAFATLAVGHLNLISVAFAVLFIGLGVDFAIQFS 344
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   406 ENTFRHLEDGTSPIKAAIDSAREIAGSviamtITLAAVYAPIGFMggltGKLFTEFAFT-----LAG-SVLISGFIALTL 479
Cdd:TIGR03480  345 LRYREERFRGGNHREALSVAARRMGAA-----LLLAALATAAGFF----AFLPTDYKGVselgiIAGtGMFIALFVTLTV 415

                   ..
gi 937073987   480 TP 481
Cdd:TIGR03480  416 LP 417
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
836-1001 1.47e-03

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 42.52  E-value: 1.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   836 GQLRQFLQEGSSLVTTFFLALVIIylVLAAQFESLRDPLVVLTSVPLSIFGALMPLYLGIDTLNIYTEVGLVTLIGLISK 915
Cdd:TIGR00921  559 AEMHELVNEGMRRMTIAGAILVLM--ILLAVFRNPIKAVFPLIAIGSGILWAIGLMGLRGIPSFLAMATTISIILGLGMD 636
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   916 HGILIVEfanQMQQELKCSRREAAIRSATVRMRPVLMTTAAMVVGVVPLLIASGAGAQSRFsiGLVITVGMSVGTLFTLF 995
Cdd:TIGR00921  637 YSIHLAE---RYFEERKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNF--GLVQGIGVLSSLTAALV 711

                   ....*.
gi 937073987   996 VVPTIY 1001
Cdd:TIGR00921  712 VFPALL 717
PRK13024 PRK13024
bifunctional preprotein translocase subunit SecD/SecF; Reviewed
304-490 2.42e-03

bifunctional preprotein translocase subunit SecD/SecF; Reviewed


Pssm-ID: 237276 [Multi-domain]  Cd Length: 755  Bit Score: 41.76  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  304 QIQAG-LPegIKADVIYdstkfiETSI------DEVAKTLIeAALIVVIVIFAFLGSM--RAMLIPLVTIPLSLIGSMFF 374
Cdd:PRK13024  238 LLNAGaLP--APLKIIE------SRSVgptlgqDAIDAGII-AGIIGFALIFLFMLVYygLPGLIANIALLLYIFLTLGA 308
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  375 MLSMGFSINLLTLLAMVLAISLVVDDAIVVVENTFRHLEDGTSpIKAAIDSAREIAGSVIA---MTITLAAVyapIGFMG 451
Cdd:PRK13024  309 LSSLGAVLTLPGIAGLVLGIGMAVDANVLIFERIKEELRKGKS-LKKAFKKGFKNAFSTILdsnITTLIAAA---ILFFF 384
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 937073987  452 GlTGkLFTEFAFTLAGSVLISGFIALTLTPMMCSKLLNK 490
Cdd:PRK13024  385 G-TG-PVKGFATTLIIGILASLFTAVFLTRLLLELLVKR 421
COG4258 COG4258
Predicted exporter [General function prediction only];
339-483 3.72e-03

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 41.38  E-value: 3.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  339 AALIVVIVIFAFLGSMRAMLIPLVTIPLSLIGSMFFMLSMGFSINLLTLLAMVLAISLVVDDAIVVVENTFRHLEDGTSp 418
Cdd:COG4258   648 ALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYALFFTEGLLDKGELART- 726
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987  419 ikaaidsareiagsviAMTITLAAVYAPIGFmgGLTGklfteFAFTLA----GSVLISG-FIALTLTPMM 483
Cdd:COG4258   727 ----------------LLSILLAALTTLLGF--GLLA-----FSSTPAlrsfGLTVLLGiLLALLLAPLL 773
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
307-481 4.77e-03

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 40.98  E-value: 4.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   307 AGLPEGIKADVIYDSTKFIETS---IDEVAKTLIEAALIVVIVIFAFLGSMR---AMLIPLVTIPLSLIGSMFFMlSMGF 380
Cdd:TIGR00921  541 EHPPPGVKVGVTGLPVAFAEMHelvNEGMRRMTIAGAILVLMILLAVFRNPIkavFPLIAIGSGILWAIGLMGLR-GIPS 619
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   381 SINLLTLLAMVLAISlvVDDAIVVVENTFRHLeDGTSPiKAAIDSAREIAGSviamTITLAAVYAPIGFMGGLTGKL--F 458
Cdd:TIGR00921  620 FLAMATTISIILGLG--MDYSIHLAERYFEER-KEHGP-KEAITHTMERTGP----GILFSGLTTAGGFLSLLLSHFpiM 691
                          170       180
                   ....*....|....*....|...
gi 937073987   459 TEFAFTLAGSVLISGFIALTLTP 481
Cdd:TIGR00921  692 RNFGLVQGIGVLSSLTAALVVFP 714
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
846-1004 7.86e-03

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 39.58  E-value: 7.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   846 SSLVTTFFLALVIIYLVLAAQFESLRDPLVVLTSVPLSIFGA--LMPLYLGIDTLNIYTEV-GLVT--LIGLISKHGILI 920
Cdd:pfam03176  142 RDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAqgLVAILAHILGIGLSTFAlNLLVvlLIAVGTDYALFL 221
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937073987   921 VefaNQMQQELKC-SRREAAIRSAtvrmrpvLMTTAAMVVG---VVPLLIASGAGAQSRF--SIGLVITVGMSVGTLFTL 994
Cdd:pfam03176  222 V---SRYREELRAgEDREEAVIRA-------VRGTGKVVTAaglTVAIAMLALSFARLPVfaQVGPTIAIGVLVDVLAAL 291
                          170
                   ....*....|
gi 937073987   995 FVVPTIYTYL 1004
Cdd:pfam03176  292 TLLPALLALL 301
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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