|
Name |
Accession |
Description |
Interval |
E-value |
| PRK08840 |
PRK08840 |
replicative DNA helicase; Provisional |
3-458 |
0e+00 |
|
replicative DNA helicase; Provisional
Pssm-ID: 181562 [Multi-domain] Cd Length: 464 Bit Score: 809.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 3 KPDKQVDTLKVPPHSIEAEQSVLGGLMLDNQAFDRVAELVVAQDFYTRTHKLIFEAMVNLAEGGDPIDLITISESLEKNN 82
Cdd:PRK08840 9 IPDAQVDAIKVPPHSLEAEQSVIGGLLLDNERWDTVAEKVVASDFYSRPHRLIFEGVKSILEAGKPLDLITLSEHLERRE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 83 QLSSVGGFAYLAEIAKNTPSAANIDAYANIVRERAVIREMIGVANEIAEAGFSPEGRTSHDLLDFAESKVFKIAEQRSKS 162
Cdd:PRK08840 89 QLEDVGGFAYLADLAKNTPSAANINAYADIVAERALVRNLIGVANEIADAGYDPQGRTSEDLLDMAESKVFAIAEARTSE 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 163 TEGPQNLHSILEKTVDKIEELYQSPQDGVTGVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEHAAMTQDKP 242
Cdd:PRK08840 169 NEGPQNVDSILEKTLERIELLYKTPQDGVTGVDTGFTDLNKKTAGLQGSDLIIVAARPSMGKTTFAMNLCENAAMDQDKP 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 243 VLIYSLEMPSEQIMMRMLASLGRINQTKVRTGQLDDDDWARLSSTMGLLMEKGKMYVDDASGLTPTDVRSRARRIARDHG 322
Cdd:PRK08840 249 VLIFSLEMPAEQLMMRMLASLSRVDQTKIRTGQLDDEDWARISSTMGILMEKKNMYIDDSSGLTPTEVRSRARRIAREHG 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 323 GISMIMVDYLQLMRVPSLSDNRTLEIAEISRSLKALAKELQCPVIALSQLNRTLEQRADKRPINSDLRESGSIEQDADLI 402
Cdd:PRK08840 329 GLSMIMVDYLQLMRVPALSDNRTLEIAEISRSLKALAKELNVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLI 408
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 937116724 403 MFIYRDEVYNEDSAEKGVAEIIIGKQRNGPIGKVRLTFQGQFSRFDNYAGPAMDDE 458
Cdd:PRK08840 409 MFIYRDEVYNPDSPLKGTAEIIIGKQRNGPIGSVRLTFQGQYSRFDNYAGPAFDDE 464
|
|
| DnaB |
TIGR00665 |
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein ... |
14-451 |
0e+00 |
|
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273206 [Multi-domain] Cd Length: 432 Bit Score: 750.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 14 PPHSIEAEQSVLGGLMLDNQAFDRVAELVVAQDFYTRTHKLIFEAMVNLAEGGDPIDLITISESLEKNNQLSSVGGFAYL 93
Cdd:TIGR00665 1 PPHNIEAEQAVLGAILLDNEAIDDVAEILKPEDFYRPAHRLIFQAILDLYEKGEPIDLVTVAEELEKDGELEEVGGLAYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 94 AEIAKNTPSAANIDAYANIVRERAVIREMIGVANEIAEAGFSPEGrTSHDLLDFAESKVFKIAEQRSKstEGPQNLHSIL 173
Cdd:TIGR00665 81 AELASNVPSAANIEYYAEIVKEKAILRRLIQAGTEIVELAYDPTG-DVEELLDEAEQKIFEIAESRTS--KGFKSIKEIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 174 EKTVDKIEELYQSpQDGVTGVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEHAAMTQDKPVLIYSLEMPSE 253
Cdd:TIGR00665 158 KEAVEEIEELYER-KGGITGVPTGFTDLDKLTSGLQPSDLIILAARPSMGKTAFALNIAENAAIKEGKPVAFFSLEMSAE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 254 QIMMRMLASLGRINQTKVRTGQLDDDDWARLSSTMGLLMEKgKMYVDDASGLTPTDVRSRARRIARDHGgISMIMVDYLQ 333
Cdd:TIGR00665 237 QLVMRMLSSESRVDSQKLRTGRLSDEDWEKLTEAAGELSEA-PLYIDDTPGLTITELRAKARRLKREHG-LGLIVIDYLQ 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 334 LMRVPSLSDNRTLEIAEISRSLKALAKELQCPVIALSQLNRTLEQRADKRPINSDLRESGSIEQDADLIMFIYRDEVYNE 413
Cdd:TIGR00665 315 LMSGSGRSENRQQEVSEISRSLKALAKELNVPVIALSQLSRSVEQREDKRPQLSDLRESGSIEQDADIVMFLYRDEYYNP 394
|
410 420 430
....*....|....*....|....*....|....*...
gi 937116724 414 DSAEKGVAEIIIGKQRNGPIGKVRLTFQGQFSRFDNYA 451
Cdd:TIGR00665 395 DSEDKGIAEIIIAKQRNGPTGTVKLAFLGEYTRFENLA 432
|
|
| DnaB |
COG0305 |
Replicative DNA helicase [Replication, recombination and repair]; |
17-451 |
0e+00 |
|
Replicative DNA helicase [Replication, recombination and repair];
Pssm-ID: 440074 [Multi-domain] Cd Length: 429 Bit Score: 719.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 17 SIEAEQSVLGGLMLDNQAFDRVAELVVAQDFYTRTHKLIFEAMVNLAEGGDPIDLITISESLEKNNQLSSVGGFAYLAEI 96
Cdd:COG0305 1 NIEAEQAVLGALLLDNDALDEVADILKPEDFYRPAHRLIFEAILDLYERGEPIDLVTVAEELEKRGELEEVGGAAYLAEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 97 AKNTPSAANIDAYANIVRERAVIREMIGVANEIAEAGFSPEgRTSHDLLDFAESKVFKIAEQRSKSteGPQNLHSILEKT 176
Cdd:COG0305 81 AENVPSAANIEYYARIVKEKALLRRLIEAGTEIVELAYDED-EDVDELLDEAEQKIFEIAEKRSSK--GFVSISDILKEA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 177 VDKIEELYQSPqDGVTGVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEHAAMTQDKPVLIYSLEMPSEQIM 256
Cdd:COG0305 158 LERIEELYKNG-GGITGVPTGFTDLDKLTGGLQPGDLIILAARPSMGKTAFALNIARNAAIKEGKPVAIFSLEMSAEQLV 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 257 MRMLASLGRINQTKVRTGQLDDDDWARLSSTMGLLMEKgKMYVDDASGLTPTDVRSRARRIARDHGgISMIMVDYLQLMR 336
Cdd:COG0305 237 MRLLSSEARIDSSKLRTGKLSDEDWERLSSAAGELSEA-PIYIDDTPGLTIAEIRAKARRLKREHG-LGLIVIDYLQLMS 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 337 VPSLSDNRTLEIAEISRSLKALAKELQCPVIALSQLNRTLEQRADKRPINSDLRESGSIEQDADLIMFIYRDEVYNEDSA 416
Cdd:COG0305 315 GSGRSENRQQEISEISRSLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGSIEQDADVVMFLYRDEYYNPDSE 394
|
410 420 430
....*....|....*....|....*....|....*
gi 937116724 417 EKGVAEIIIGKQRNGPIGKVRLTFQGQFSRFDNYA 451
Cdd:COG0305 395 DKGIAEIIIAKQRNGPTGTVKLAFDGEYTRFENLA 429
|
|
| dnaB_SPI-7_type |
NF040583 |
SPI-7-type island replicative DNA helicase; Members of this family are DnaB-PI, a ... |
14-450 |
0e+00 |
|
SPI-7-type island replicative DNA helicase; Members of this family are DnaB-PI, a pathogenicity island (PI) variant of the replicative DNA helicase DnaB. Members are found with other conjugative element replication proteins such as ParA, ParB in genetic islands whose core proteins (but not cargo proteins) are shared with the Salmonella typhi SPI-7 island.
Pssm-ID: 468557 [Multi-domain] Cd Length: 434 Bit Score: 626.65 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 14 PPHSIEAEQSVLGGLMLDNQAFDRVAELVVAQDFYTRTHKLIFEAMVNLAEGGDPIDLITISESLEKNNQLSSVGGFAYL 93
Cdd:NF040583 1 GPYSVEAEQSVLGGLMLDNDRWDDVALLLAADDFYSRAHRIIFRAMARLVSAGQPIDLITLSESLEQQGQLEQVGGFAYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 94 AEIAKNTPSAANIDAYANIVRERAVIREMIGVANEIAEAGFSPEGRTShDLLDFAESKVFKIAEQRSksTEGPQNLHSIL 173
Cdd:NF040583 81 AELSKNTPSAANIVAYAEIVAEYSRARQLLALGHDLSADASAPRADIA-DLLEQAEQRLFDIAEQAE--PQQEVTLIEGL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 174 EKTVDKIEELYQSPqDGVTGVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEHAAMTQ-DKPVLIYSLEMPS 252
Cdd:NF040583 158 ETLVSELELRCQSG-NGITGTPTGFAELDEMTCGLQPGDLILLAARPSMGKTALALAFCLGALRGKpDKVVQIYSLEMPT 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 253 EQIMMRMLASLGRINQTKVRTGQLDDDDWARLSSTMGLLME-KGKMYVDDASGLTPTDVRSRARRIARDHGGISMIMVDY 331
Cdd:NF040583 237 EQLLMRLVSMLGRVPLQRLRSGLLDDEDWARISQAMALLTDwKDRLIIDDTSYLTPALLRARARRNARKYGKPSLIMVDY 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 332 LQLMRVPSlSDNRTLEIAEISRSLKALAKELQCPVIALSQLNRTLEQRADKRPINSDLRESGSIEQDADLIMFIYRDEVY 411
Cdd:NF040583 317 LQLMRCPG-QENRTQEIAEISRSLKALAKEMGCPVLALSQLNRQLESRADKRPNNGDLRDSGALEQDADLIMFIYRDEVY 395
|
410 420 430
....*....|....*....|....*....|....*....
gi 937116724 412 NEDSAEKGVAEIIIGKQRNGPIGKVRLTFQGQFSRFDNY 450
Cdd:NF040583 396 NPNTPDKGIAEIIIGKQRQGPTGTVKVQFDGRYTRFSDL 434
|
|
| DnaB_C |
pfam03796 |
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ... |
193-449 |
7.71e-165 |
|
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.
Pssm-ID: 427509 [Multi-domain] Cd Length: 254 Bit Score: 464.58 E-value: 7.71e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 193 GVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEHAAMTQDKPVLIYSLEMPSEQIMMRMLASLGRINQTKVR 272
Cdd:pfam03796 1 GLPTGFTDLDRLTGGLQPGDLIIIAARPSMGKTAFALNIARNAAVKHKKPVAIFSLEMSAEQLVMRLLASEAGVDSQKLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 273 TGQLDDDDWARLSSTMGLLMEKgKMYVDDASGLTPTDVRSRARRIARDHGgISMIMVDYLQLMRVPSLSDNRTLEIAEIS 352
Cdd:pfam03796 81 TGQLTDEDWEKLAKAAGRLSEA-PLYIDDTPGLSIAEIRAKARRLKREHG-LGLIVIDYLQLMSGGSRGENRQQEISEIS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 353 RSLKALAKELQCPVIALSQLNRTLEQRADKRPINSDLRESGSIEQDADLIMFIYRDEVYNEDSaEKGVAEIIIGKQRNGP 432
Cdd:pfam03796 159 RSLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGAIEQDADVVMFLYRDEYYNPKE-PEGKAEIIIAKQRNGP 237
|
250
....*....|....*..
gi 937116724 433 IGKVRLTFQGQFSRFDN 449
Cdd:pfam03796 238 TGTVKLAFLGEYTRFEN 254
|
|
| DnaB_C |
cd00984 |
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase ... |
193-449 |
5.59e-156 |
|
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.
Pssm-ID: 410864 [Multi-domain] Cd Length: 256 Bit Score: 441.95 E-value: 5.59e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 193 GVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEHAAMTQDKPVLIYSLEMPSEQIMMRMLASLGRINQTKVR 272
Cdd:cd00984 1 GLPTGFTDLDKLTGGLQPGDLIIIAARPSMGKTAFALNIAENIALDEGLPVLFFSLEMSAEQLAERLLSSESGVSLSKLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 273 TGQLDDDDWARLSSTMGLLMEKgKMYVDDASGLTPTDVRSRARRIARDHGGISMIMVDYLQLMRVPSLSDNRTLEIAEIS 352
Cdd:cd00984 81 TGRLDDEDWERLTAAMGELSEL-PLYIDDTPGLTVDEIRAKARRLKREHGGLGLIVIDYLQLIRGSKRAENRQQEVAEIS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 353 RSLKALAKELQCPVIALSQLNRTLEQRADKRPINSDLRESGSIEQDADLIMFIYRDEVYNEDSAEKGVAEIIIGKQRNGP 432
Cdd:cd00984 160 RSLKALAKELNVPVIALSQLNRGVESRTDKRPMLSDLRESGSIEQDADVVIFLYRDEYYDKDSEDKGIAEIIIAKNRNGP 239
|
250
....*....|....*..
gi 937116724 433 IGKVRLTFQGQFSRFDN 449
Cdd:cd00984 240 TGTVYLAFNPEYTRFTD 256
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK08840 |
PRK08840 |
replicative DNA helicase; Provisional |
3-458 |
0e+00 |
|
replicative DNA helicase; Provisional
Pssm-ID: 181562 [Multi-domain] Cd Length: 464 Bit Score: 809.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 3 KPDKQVDTLKVPPHSIEAEQSVLGGLMLDNQAFDRVAELVVAQDFYTRTHKLIFEAMVNLAEGGDPIDLITISESLEKNN 82
Cdd:PRK08840 9 IPDAQVDAIKVPPHSLEAEQSVIGGLLLDNERWDTVAEKVVASDFYSRPHRLIFEGVKSILEAGKPLDLITLSEHLERRE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 83 QLSSVGGFAYLAEIAKNTPSAANIDAYANIVRERAVIREMIGVANEIAEAGFSPEGRTSHDLLDFAESKVFKIAEQRSKS 162
Cdd:PRK08840 89 QLEDVGGFAYLADLAKNTPSAANINAYADIVAERALVRNLIGVANEIADAGYDPQGRTSEDLLDMAESKVFAIAEARTSE 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 163 TEGPQNLHSILEKTVDKIEELYQSPQDGVTGVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEHAAMTQDKP 242
Cdd:PRK08840 169 NEGPQNVDSILEKTLERIELLYKTPQDGVTGVDTGFTDLNKKTAGLQGSDLIIVAARPSMGKTTFAMNLCENAAMDQDKP 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 243 VLIYSLEMPSEQIMMRMLASLGRINQTKVRTGQLDDDDWARLSSTMGLLMEKGKMYVDDASGLTPTDVRSRARRIARDHG 322
Cdd:PRK08840 249 VLIFSLEMPAEQLMMRMLASLSRVDQTKIRTGQLDDEDWARISSTMGILMEKKNMYIDDSSGLTPTEVRSRARRIAREHG 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 323 GISMIMVDYLQLMRVPSLSDNRTLEIAEISRSLKALAKELQCPVIALSQLNRTLEQRADKRPINSDLRESGSIEQDADLI 402
Cdd:PRK08840 329 GLSMIMVDYLQLMRVPALSDNRTLEIAEISRSLKALAKELNVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLI 408
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 937116724 403 MFIYRDEVYNEDSAEKGVAEIIIGKQRNGPIGKVRLTFQGQFSRFDNYAGPAMDDE 458
Cdd:PRK08840 409 MFIYRDEVYNPDSPLKGTAEIIIGKQRNGPIGSVRLTFQGQYSRFDNYAGPAFDDE 464
|
|
| PRK08006 |
PRK08006 |
replicative DNA helicase DnaB; |
5-458 |
0e+00 |
|
replicative DNA helicase DnaB;
Pssm-ID: 181193 [Multi-domain] Cd Length: 471 Bit Score: 800.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 5 DKQVDTLKVPPHSIEAEQSVLGGLMLDNQAFDRVAELVVAQDFYTRTHKLIFEAMVNLAEGGDPIDLITISESLEKNNQL 84
Cdd:PRK08006 18 DPQVAGLKVPPHSIEAEQSVLGGLMLDNERWDDVAERVVADDFYTRPHRHIFTEMARLQESGSPIDLITLAESLERQGQL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 85 SSVGGFAYLAEIAKNTPSAANIDAYANIVRERAVIREMIGVANEIAEAGFSPEGRTSHDLLDFAESKVFKIAEQRSKSTE 164
Cdd:PRK08006 98 DSVGGFAYLAELSKNTPSAANISAYADIVRERAVVREMISVANEIADAGYDPQGRTSEDLLDLAESRVFQIAESRANKDE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 165 GPQNLHSILEKTVDKIEELYQSPQDGVTGVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEHAAMTQDKPVL 244
Cdd:PRK08006 178 GPKNIADILDATVARIEQLFQQPHDGVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLCENAAMLQDKPVL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 245 IYSLEMPSEQIMMRMLASLGRINQTKVRTGQLDDDDWARLSSTMGLLMEKGKMYVDDASGLTPTDVRSRARRIARDHGGI 324
Cdd:PRK08006 258 IFSLEMPGEQIMMRMLASLSRVDQTRIRTGQLDDEDWARISGTMGILLEKRNMYIDDSSGLTPTEVRSRARRIFREHGGL 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 325 SMIMVDYLQLMRVPSLSDNRTLEIAEISRSLKALAKELQCPVIALSQLNRTLEQRADKRPINSDLRESGSIEQDADLIMF 404
Cdd:PRK08006 338 SLIMIDYLQLMRVPSLSDNRTLEIAEISRSLKALAKELQVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMF 417
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 937116724 405 IYRDEVYNEDSAEKGVAEIIIGKQRNGPIGKVRLTFQGQFSRFDNYAGPAMDDE 458
Cdd:PRK08006 418 IYRDEVYHENSDLKGIAEIIIGKQRNGPIGTVRLTFNGQWSRFDNYAGPQYDDE 471
|
|
| DnaB |
TIGR00665 |
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein ... |
14-451 |
0e+00 |
|
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273206 [Multi-domain] Cd Length: 432 Bit Score: 750.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 14 PPHSIEAEQSVLGGLMLDNQAFDRVAELVVAQDFYTRTHKLIFEAMVNLAEGGDPIDLITISESLEKNNQLSSVGGFAYL 93
Cdd:TIGR00665 1 PPHNIEAEQAVLGAILLDNEAIDDVAEILKPEDFYRPAHRLIFQAILDLYEKGEPIDLVTVAEELEKDGELEEVGGLAYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 94 AEIAKNTPSAANIDAYANIVRERAVIREMIGVANEIAEAGFSPEGrTSHDLLDFAESKVFKIAEQRSKstEGPQNLHSIL 173
Cdd:TIGR00665 81 AELASNVPSAANIEYYAEIVKEKAILRRLIQAGTEIVELAYDPTG-DVEELLDEAEQKIFEIAESRTS--KGFKSIKEIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 174 EKTVDKIEELYQSpQDGVTGVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEHAAMTQDKPVLIYSLEMPSE 253
Cdd:TIGR00665 158 KEAVEEIEELYER-KGGITGVPTGFTDLDKLTSGLQPSDLIILAARPSMGKTAFALNIAENAAIKEGKPVAFFSLEMSAE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 254 QIMMRMLASLGRINQTKVRTGQLDDDDWARLSSTMGLLMEKgKMYVDDASGLTPTDVRSRARRIARDHGgISMIMVDYLQ 333
Cdd:TIGR00665 237 QLVMRMLSSESRVDSQKLRTGRLSDEDWEKLTEAAGELSEA-PLYIDDTPGLTITELRAKARRLKREHG-LGLIVIDYLQ 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 334 LMRVPSLSDNRTLEIAEISRSLKALAKELQCPVIALSQLNRTLEQRADKRPINSDLRESGSIEQDADLIMFIYRDEVYNE 413
Cdd:TIGR00665 315 LMSGSGRSENRQQEVSEISRSLKALAKELNVPVIALSQLSRSVEQREDKRPQLSDLRESGSIEQDADIVMFLYRDEYYNP 394
|
410 420 430
....*....|....*....|....*....|....*...
gi 937116724 414 DSAEKGVAEIIIGKQRNGPIGKVRLTFQGQFSRFDNYA 451
Cdd:TIGR00665 395 DSEDKGIAEIIIAKQRNGPTGTVKLAFLGEYTRFENLA 432
|
|
| DnaB |
COG0305 |
Replicative DNA helicase [Replication, recombination and repair]; |
17-451 |
0e+00 |
|
Replicative DNA helicase [Replication, recombination and repair];
Pssm-ID: 440074 [Multi-domain] Cd Length: 429 Bit Score: 719.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 17 SIEAEQSVLGGLMLDNQAFDRVAELVVAQDFYTRTHKLIFEAMVNLAEGGDPIDLITISESLEKNNQLSSVGGFAYLAEI 96
Cdd:COG0305 1 NIEAEQAVLGALLLDNDALDEVADILKPEDFYRPAHRLIFEAILDLYERGEPIDLVTVAEELEKRGELEEVGGAAYLAEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 97 AKNTPSAANIDAYANIVRERAVIREMIGVANEIAEAGFSPEgRTSHDLLDFAESKVFKIAEQRSKSteGPQNLHSILEKT 176
Cdd:COG0305 81 AENVPSAANIEYYARIVKEKALLRRLIEAGTEIVELAYDED-EDVDELLDEAEQKIFEIAEKRSSK--GFVSISDILKEA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 177 VDKIEELYQSPqDGVTGVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEHAAMTQDKPVLIYSLEMPSEQIM 256
Cdd:COG0305 158 LERIEELYKNG-GGITGVPTGFTDLDKLTGGLQPGDLIILAARPSMGKTAFALNIARNAAIKEGKPVAIFSLEMSAEQLV 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 257 MRMLASLGRINQTKVRTGQLDDDDWARLSSTMGLLMEKgKMYVDDASGLTPTDVRSRARRIARDHGgISMIMVDYLQLMR 336
Cdd:COG0305 237 MRLLSSEARIDSSKLRTGKLSDEDWERLSSAAGELSEA-PIYIDDTPGLTIAEIRAKARRLKREHG-LGLIVIDYLQLMS 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 337 VPSLSDNRTLEIAEISRSLKALAKELQCPVIALSQLNRTLEQRADKRPINSDLRESGSIEQDADLIMFIYRDEVYNEDSA 416
Cdd:COG0305 315 GSGRSENRQQEISEISRSLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGSIEQDADVVMFLYRDEYYNPDSE 394
|
410 420 430
....*....|....*....|....*....|....*
gi 937116724 417 EKGVAEIIIGKQRNGPIGKVRLTFQGQFSRFDNYA 451
Cdd:COG0305 395 DKGIAEIIIAKQRNGPTGTVKLAFDGEYTRFENLA 429
|
|
| PRK06904 |
PRK06904 |
replicative DNA helicase; Validated |
5-459 |
0e+00 |
|
replicative DNA helicase; Validated
Pssm-ID: 136106 [Multi-domain] Cd Length: 472 Bit Score: 707.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 5 DKQVDTLKVPPHSIEAEQSVLGGLMLDNQAFDRVAELVVAQDFYTRTHKLIFEAMVNLAEGGDPIDLITISESLEKNNQL 84
Cdd:PRK06904 14 DKKTAQVLIPPHSIEAEQAVLGGIMLDNRHWDSVAERVIADDFYTFEHRIIFQEMELLFRQNTPIDLLTLDQALKTKGKS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 85 SSVGGFAYLAEIAKNTPSAANIDAYANIVRERAVIREMIGVANEIAEAGFSPEGRTSHDLLDFAESKVFKIAEQRSKSTE 164
Cdd:PRK06904 94 DEVGGFAYLAELSNNTPSAANILAYADIVREKAILRELISVGNNIAKNAYSPKGQDIKDILDEAERDVFSIAEKRTTANE 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 165 GPQNLHSILEKTVDKIEELYQSP-QDGVTGVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEHAAMTQDKPV 243
Cdd:PRK06904 174 GPQNVINLLENTIDKIENLAATPtNNGVTGVTTGFTDLDKKTAGLQPSDLIIVAARPSMGKTTFAMNLCENAAMASEKPV 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 244 LIYSLEMPSEQIMMRMLASLGRINQTKVRTGQ-LDDDDWARLSSTMGLLMEKGKMYVDDASGLTPTDVRSRARRIARDHG 322
Cdd:PRK06904 254 LVFSLEMPAEQIMMRMLASLSRVDQTKIRTGQnLDQQDWAKISSTVGMFKQKPNLYIDDSSGLTPTELRSRARRVYRENG 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 323 GISMIMVDYLQLMRVPSLSDNRTLEIAEISRSLKALAKELQCPVIALSQLNRTLEQRADKRPINSDLRESGSIEQDADLI 402
Cdd:PRK06904 334 GLSLIMVDYLQLMRAPGFEDNRTLEIAEISRSLKALAKELKVPVVALSQLNRTLENRGDKRPVNSDLRESGSIEQDADLI 413
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 937116724 403 MFIYRDEVYNEDSAE-KGVAEIIIGKQRNGPIGKVRLTFQGQFSRFDNYAG-PAMDDEY 459
Cdd:PRK06904 414 MFIYRDEVYNETTEDnKGVAEIIIGKQRNGPIGRVRLAFQGQYSRFDNLANiPQYYDKY 472
|
|
| PRK05748 |
PRK05748 |
replicative DNA helicase; Provisional |
5-451 |
0e+00 |
|
replicative DNA helicase; Provisional
Pssm-ID: 180232 [Multi-domain] Cd Length: 448 Bit Score: 706.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 5 DKQVDTLKVPPHSIEAEQSVLGGLMLDNQAFDRVAELVVAQDFYTRTHKLIFEAMVNLAEGGDPIDLITISESLEKNNQL 84
Cdd:PRK05748 1 MSEVAALRVPPQSIEAEQAVLGAIFLDPDALITVSEYLSPDDFYRHAHRLIFRAMLKLSDRGEPIDVVTVTEILDDQGDL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 85 SSVGGFAYLAEIAKNTPSAANIDAYANIVRERAVIREMIGVANEIAEAGFSPEGrTSHDLLDFAESKVFKIAEQRSKSte 164
Cdd:PRK05748 81 EEVGGLSYLAELANSVPTAANIEYYAKIVAEKAMLRRLIRTATEIANDAYEPED-DADEILDEAEKKIFEVSERRNKS-- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 165 GPQNLHSILEKTVDKIEELYQSpQDGVTGVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEHAAMTQDKPVL 244
Cdd:PRK05748 158 GFKNIKDVLVKAYDRIEMLHNQ-TGDITGIPTGFTDLDKMTSGLQPNDLIIVAARPSVGKTAFALNIAQNVATKTDKNVA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 245 IYSLEMPSEQIMMRMLASLGRINQTKVRTGQLDDDDWARLSSTMGLLMEKGkMYVDDASGLTPTDVRSRARRIARDHGGI 324
Cdd:PRK05748 237 IFSLEMGAESLVMRMLCAEGNIDAQRLRTGQLTDDDWPKLTIAMGSLSDAP-IYIDDTPGIKVTEIRARCRRLAQEHGGL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 325 SMIMVDYLQLMRVP-SLSDNRTLEIAEISRSLKALAKELQCPVIALSQLNRTLEQRADKRPINSDLRESGSIEQDADLIM 403
Cdd:PRK05748 316 GLILIDYLQLIQGSgRSGENRQQEVSEISRSLKALAKELKVPVIALSQLSRGVEQRQDKRPVMSDIRESGSIEQDADIVA 395
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 937116724 404 FIYRDEVYNEDSAEKGVAEIIIGKQRNGPIGKVRLTFQGQFSRFDNYA 451
Cdd:PRK05748 396 FLYRDDYYDEETENKNTIEIIIAKQRNGPVGTVELAFQKEYNKFVNLA 443
|
|
| dnaB_SPI-7_type |
NF040583 |
SPI-7-type island replicative DNA helicase; Members of this family are DnaB-PI, a ... |
14-450 |
0e+00 |
|
SPI-7-type island replicative DNA helicase; Members of this family are DnaB-PI, a pathogenicity island (PI) variant of the replicative DNA helicase DnaB. Members are found with other conjugative element replication proteins such as ParA, ParB in genetic islands whose core proteins (but not cargo proteins) are shared with the Salmonella typhi SPI-7 island.
Pssm-ID: 468557 [Multi-domain] Cd Length: 434 Bit Score: 626.65 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 14 PPHSIEAEQSVLGGLMLDNQAFDRVAELVVAQDFYTRTHKLIFEAMVNLAEGGDPIDLITISESLEKNNQLSSVGGFAYL 93
Cdd:NF040583 1 GPYSVEAEQSVLGGLMLDNDRWDDVALLLAADDFYSRAHRIIFRAMARLVSAGQPIDLITLSESLEQQGQLEQVGGFAYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 94 AEIAKNTPSAANIDAYANIVRERAVIREMIGVANEIAEAGFSPEGRTShDLLDFAESKVFKIAEQRSksTEGPQNLHSIL 173
Cdd:NF040583 81 AELSKNTPSAANIVAYAEIVAEYSRARQLLALGHDLSADASAPRADIA-DLLEQAEQRLFDIAEQAE--PQQEVTLIEGL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 174 EKTVDKIEELYQSPqDGVTGVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEHAAMTQ-DKPVLIYSLEMPS 252
Cdd:NF040583 158 ETLVSELELRCQSG-NGITGTPTGFAELDEMTCGLQPGDLILLAARPSMGKTALALAFCLGALRGKpDKVVQIYSLEMPT 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 253 EQIMMRMLASLGRINQTKVRTGQLDDDDWARLSSTMGLLME-KGKMYVDDASGLTPTDVRSRARRIARDHGGISMIMVDY 331
Cdd:NF040583 237 EQLLMRLVSMLGRVPLQRLRSGLLDDEDWARISQAMALLTDwKDRLIIDDTSYLTPALLRARARRNARKYGKPSLIMVDY 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 332 LQLMRVPSlSDNRTLEIAEISRSLKALAKELQCPVIALSQLNRTLEQRADKRPINSDLRESGSIEQDADLIMFIYRDEVY 411
Cdd:NF040583 317 LQLMRCPG-QENRTQEIAEISRSLKALAKEMGCPVLALSQLNRQLESRADKRPNNGDLRDSGALEQDADLIMFIYRDEVY 395
|
410 420 430
....*....|....*....|....*....|....*....
gi 937116724 412 NEDSAEKGVAEIIIGKQRNGPIGKVRLTFQGQFSRFDNY 450
Cdd:NF040583 396 NPNTPDKGIAEIIIGKQRQGPTGTVKVQFDGRYTRFSDL 434
|
|
| PRK07004 |
PRK07004 |
replicative DNA helicase; Provisional |
1-452 |
0e+00 |
|
replicative DNA helicase; Provisional
Pssm-ID: 235907 [Multi-domain] Cd Length: 460 Bit Score: 596.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 1 MAKP-DKQVDTLKVPPHSIEAEQSVLGGLMLDNQAFDRVAELVVAQDFYTRTHKLIFEAMVNLAEGGDPIDLITISESLE 79
Cdd:PRK07004 1 MNAPaDPQLESLKVPPHSIEAEQSVLGGLLLDNAAWDRIADFLSQSDFYRYDHRIIFEHIGRLIAATRPADVITVYEALT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 80 KNNQLSSVGGFAYLAEIAKNTPSAANIDAYANIVRERAVIREMIGVANEIAEAGFSPEGRTSHDLLDFAESKVFKIAEQR 159
Cdd:PRK07004 81 TSGKAEEVGGLAYLNALAQNTPSAANIRRYAEIVRDRAVLRRLVSVADEISADAFNPQGKEVRQLLDEAESKVFSIAEEG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 160 SKSTEGPQNLHSILEKTVDKIEELY--QSPQDgVTGVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEHAAM 237
Cdd:PRK07004 161 ARGTQGFLEIGPLLTQVVERIDTLYhtANPSD-VTGTPTGFVDLDRMTSGMHGGELIIVAGRPSMGKTAFSMNIGEYVAV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 238 TQDKPVLIYSLEMPSEQIMMRMLASLGRINQTKVRTGQLDDDDWARLSSTMGLlMEKGKMYVDDASGLTPTDVRSRARRI 317
Cdd:PRK07004 240 EYGLPVAVFSMEMPGTQLAMRMLGSVGRLDQHRMRTGRLTDEDWPKLTHAVQK-MSEAQLFIDETGGLNPMELRSRARRL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 318 ARDHGGISMIMVDYLQLMRVPSLSDNRTLEIAEISRSLKALAKELQCPVIALSQLNRTLEQRADKRPINSDLRESGSIEQ 397
Cdd:PRK07004 319 ARQCGKLGLIIIDYLQLMSGSSQGENRATEISEISRSLKSLAKELDVPVIALSQLNRGLEQRPNKRPVMSDLRESGAIEQ 398
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 937116724 398 DADLIMFIYRDEVYNEDSAEKGVAEIIIGKQRNGPIGKVRLTFQGQFSRFDNYAG 452
Cdd:PRK07004 399 DADVILFIYRDEVYNPDSPDKGTAEIIIGKQRNGPIGPVRLTFLGQYTKFDNFAG 453
|
|
| PRK08760 |
PRK08760 |
replicative DNA helicase; Provisional |
3-456 |
0e+00 |
|
replicative DNA helicase; Provisional
Pssm-ID: 181547 [Multi-domain] Cd Length: 476 Bit Score: 529.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 3 KPDKQVDTLKVPPHSIEAEQSVLGGLMLDNQAFDRVAELVVAQDFYTRTHKLIFEAMVNLAEGGDPIDLITISESLEKNN 82
Cdd:PRK08760 22 RPEPRLDQLRVPPHSVEAEQAVLGGLMLAPDALDRVNDQLTENDFYRRDHRLIYRAIRELSEKDRPFDAVTLGEWFESQG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 83 QLSSVGGFAYLAEIAKNTPSAANIDAYANIVRERAVIREMIGVANEIAEAGFSPEGRTSHDLLDFAESKVFKIAEQRSKS 162
Cdd:PRK08760 102 KLEQVGDGAYLIELASTTPSAANIAAYAEIVRDKAVLRQLIEVGTTIVNDGFQPEGRESIELLASAEKAVFKIAEAGARG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 163 TEGPQNLHSILEKTVDKIEELYQSPQDgVTGVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEHAAMTQDKP 242
Cdd:PRK08760 182 RTDFVAMPGALKDAFEELRNRFENGGN-ITGLPTGYNDFDAMTAGLQPTDLIILAARPAMGKTTFALNIAEYAAIKSKKG 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 243 VLIYSLEMPSEQIMMRMLASLGRINQTKVRTGQLDDDDWARLSSTMGLLMEKgKMYVDDASGLTPTDVRSRARRIARDHg 322
Cdd:PRK08760 261 VAVFSMEMSASQLAMRLISSNGRINAQRLRTGALEDEDWARVTGAIKMLKET-KIFIDDTPGVSPEVLRSKCRRLKREH- 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 323 GISMIMVDYLQLMRVPSLSDNRTLEIAEISRSLKALAKELQCPVIALSQLNRTLEQRADKRPINSDLRESGSIEQDADLI 402
Cdd:PRK08760 339 DLGLIVIDYLQLMSVPGNSENRATEISEISRSLKGLAKELNVPVIALSQLNRSLETRTDKRPVMADLRESGAIEQDADMI 418
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 937116724 403 MFIYRDEVYNED-SAEKGVAEIIIGKQRNGPIGKVRLTFQGQFSRFDNYAGPAMD 456
Cdd:PRK08760 419 VFIYRDDYYNKEnSPDKGLAEIIIGKHRGGPTGSCKLKFFGEYTRFDNLAHDSVG 473
|
|
| DnaB_C |
pfam03796 |
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ... |
193-449 |
7.71e-165 |
|
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.
Pssm-ID: 427509 [Multi-domain] Cd Length: 254 Bit Score: 464.58 E-value: 7.71e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 193 GVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEHAAMTQDKPVLIYSLEMPSEQIMMRMLASLGRINQTKVR 272
Cdd:pfam03796 1 GLPTGFTDLDRLTGGLQPGDLIIIAARPSMGKTAFALNIARNAAVKHKKPVAIFSLEMSAEQLVMRLLASEAGVDSQKLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 273 TGQLDDDDWARLSSTMGLLMEKgKMYVDDASGLTPTDVRSRARRIARDHGgISMIMVDYLQLMRVPSLSDNRTLEIAEIS 352
Cdd:pfam03796 81 TGQLTDEDWEKLAKAAGRLSEA-PLYIDDTPGLSIAEIRAKARRLKREHG-LGLIVIDYLQLMSGGSRGENRQQEISEIS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 353 RSLKALAKELQCPVIALSQLNRTLEQRADKRPINSDLRESGSIEQDADLIMFIYRDEVYNEDSaEKGVAEIIIGKQRNGP 432
Cdd:pfam03796 159 RSLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGAIEQDADVVMFLYRDEYYNPKE-PEGKAEIIIAKQRNGP 237
|
250
....*....|....*..
gi 937116724 433 IGKVRLTFQGQFSRFDN 449
Cdd:pfam03796 238 TGTVKLAFLGEYTRFEN 254
|
|
| PRK05595 |
PRK05595 |
replicative DNA helicase; Provisional |
11-450 |
1.25e-163 |
|
replicative DNA helicase; Provisional
Pssm-ID: 235525 [Multi-domain] Cd Length: 444 Bit Score: 468.92 E-value: 1.25e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 11 LKVPPHSIEAEQSVLGGLMLDNQAFDRVAELVVAQDFYTRTHKLIFEAMVNLAEGGDPIDLITISESLEKNNQLSSVGGF 90
Cdd:PRK05595 5 IRSLPQSIEAEQSVLGAMIIDKTSIAEAAEVLKSEDFYRDSHKVIFSAIIELYQKDIAVDMLTLTENLKSTDKLEAAGGV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 91 AYLAEIAKNTPSAANIDAYANIVRERAVIREMIGVANEIAEAGFSPEGRTShDLLDFAESKVFKIAEQRSKSTEGPQNlh 170
Cdd:PRK05595 85 TYITELSNSIVSTANIQSYIKIVKDKSTLRRLIKSSTEIIENSYNNQDDVE-KVIDSAEKKIFDISEKRTTSDFEPLS-- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 171 SILEKTVDKIEELYQSpQDGVTGVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEHAAMTQDKPVLIYSLEM 250
Cdd:PRK05595 162 NVLERGFEQIENLFNN-KGETTGVASGFRELDAKTSGFQKGDMILIAARPSMGKTTFALNIAEYAALREGKSVAIFSLEM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 251 PSEQIMMRMLASLGRINQTKVRTGQLDDDDWARLSSTMGLLmEKGKMYVDDASGLTPTDVRSRARRIARDHGgISMIMVD 330
Cdd:PRK05595 241 SKEQLAYKLLCSEANVDMLRLRTGNLEDKDWENIARASGPL-AAAKIFIDDTAGVSVMEMRSKCRRLKIEHG-IDMILID 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 331 YLQLMRVPSLSDNRTLEIAEISRSLKALAKELQCPVIALSQLNRTLEQRADKRPINSDLRESGSIEQDADLIMFIYRDEV 410
Cdd:PRK05595 319 YLQLMSGGKGSESRQQEVSEISRSIKALAKEMECPVIALSQLSRAPEQRADHRPMLSDLRESGSIEQDADVVMFLYRDEY 398
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 937116724 411 YNEDSAEKGVAEIIIGKQRNGPIGKVRLTFQGQFSRFDNY 450
Cdd:PRK05595 399 YNKETEDKNVAECIIAKQRNGPTGTVKLAWLGQYSKFGNL 438
|
|
| phage_DnaB |
TIGR03600 |
phage replicative helicase, DnaB family, HK022 subfamily; Members of this family are phage (or ... |
17-440 |
2.69e-163 |
|
phage replicative helicase, DnaB family, HK022 subfamily; Members of this family are phage (or prophage-region) homologs of the bacterial homohexameric replicative helicase DnaB. Some phage may rely on host DnaB, while others encode their own verions. This model describes the largest phage-specific clade among the close homologs of DnaB, but there are, or course, other DnaB homologs from phage that fall outside the scope of this model. [Mobile and extrachromosomal element functions, Prophage functions]
Pssm-ID: 274672 [Multi-domain] Cd Length: 420 Bit Score: 467.27 E-value: 2.69e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 17 SIEAEQSVLGGLMLDNQAFDRVAELVVAQDFYTRTHKLIFEAMVNLAEGGDPIDLITISESLEKNNQLSSVGGFAYLAEI 96
Cdd:TIGR03600 1 SIEAEQAVLGGLLLDNDFIERVMAILKPEHFYSQDHRIIFEAMLDMFAENRPVDPLTLADKLEAEGEAEKVGGLAYLAEI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 97 AKNTPSAANIDAYANIVRERAVIREMIGVANEIAEAGFSPEGRTSHDLLDFAESKVFKIAeQRSKSTEGPQNLHSILEKT 176
Cdd:TIGR03600 81 SNNTPSAANISSYARIVREKAKERKLIAACQRIITLACSPDGGTAEQKVEEAQAALLALT-MSDGQEDGFVTFGEVLEDV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 177 VDKIEELYqSPQDGVTGVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEHAAMTQDKPVLIYSLEMPSEQIM 256
Cdd:TIGR03600 160 VRDLDKRF-NPKGELTGLSTGLPKLDRLTNGLVKGDLIVIGARPSMGKTTLALNIAENVALREGKPVLFFSLEMSAEQLG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 257 MRMLASLGRINQTKVRTGQLDDDDWARLSSTMGLLMEKgKMYVDDASGLTPTDVRSRARRIARDHGGISMIMVDYLQLMR 336
Cdd:TIGR03600 239 ERLLASKSGINTGNIRTGRFNDSEFNRLLNAVDRLSEK-DLYIDDTGGLTVAQIRSIARRIKRKKGGLDLIVVDYIQLMA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 337 vPSLSDNRTLEIAEISRSLKALAKELQCPVIALSQLNRTLEQRADKRPINSDLRESGSIEQDADLIMFIYRDEVYNEDSA 416
Cdd:TIGR03600 318 -PARGRDRNEELGGISRGLKALAKELDVPVVLLAQLNRGSEKRTDKRPIMSDLRDSGAIEQDADVIGLIHREGYYDAREP 396
|
410 420
....*....|....*....|....
gi 937116724 417 EKGVAEIIIGKQRNGPIGKVRLTF 440
Cdd:TIGR03600 397 PAGIAELILAKNRHGPTGTVELLF 420
|
|
| DnaB_C |
cd00984 |
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase ... |
193-449 |
5.59e-156 |
|
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.
Pssm-ID: 410864 [Multi-domain] Cd Length: 256 Bit Score: 441.95 E-value: 5.59e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 193 GVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEHAAMTQDKPVLIYSLEMPSEQIMMRMLASLGRINQTKVR 272
Cdd:cd00984 1 GLPTGFTDLDKLTGGLQPGDLIIIAARPSMGKTAFALNIAENIALDEGLPVLFFSLEMSAEQLAERLLSSESGVSLSKLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 273 TGQLDDDDWARLSSTMGLLMEKgKMYVDDASGLTPTDVRSRARRIARDHGGISMIMVDYLQLMRVPSLSDNRTLEIAEIS 352
Cdd:cd00984 81 TGRLDDEDWERLTAAMGELSEL-PLYIDDTPGLTVDEIRAKARRLKREHGGLGLIVIDYLQLIRGSKRAENRQQEVAEIS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 353 RSLKALAKELQCPVIALSQLNRTLEQRADKRPINSDLRESGSIEQDADLIMFIYRDEVYNEDSAEKGVAEIIIGKQRNGP 432
Cdd:cd00984 160 RSLKALAKELNVPVIALSQLNRGVESRTDKRPMLSDLRESGSIEQDADVVIFLYRDEYYDKDSEDKGIAEIIIAKNRNGP 239
|
250
....*....|....*..
gi 937116724 433 IGKVRLTFQGQFSRFDN 449
Cdd:cd00984 240 TGTVYLAFNPEYTRFTD 256
|
|
| PRK09165 |
PRK09165 |
replicative DNA helicase; Provisional |
4-451 |
6.00e-153 |
|
replicative DNA helicase; Provisional
Pssm-ID: 181676 [Multi-domain] Cd Length: 497 Bit Score: 443.56 E-value: 6.00e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 4 PDKQVDTLKVPPHSIEAEQSVLGGLMLDNQAFDRVAELVVAQDFYTRTHKLIFEAMVNLAEGGDPIDLITISESLEKNNQ 83
Cdd:PRK09165 11 PDAAEPEIRELPHNIEAEQALLGAILINNRALDRVSDFLKPEHFFEPLHQRIYEAIAKIIRKGKLATPVTLKTFLENDEA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 84 LSSVGGFAYLAEIAKNTPSAANIDAYANIVRERAVIREMIGVANEIAEAGF-SPEGRTSHDLLDFAESKVFKIAEQRsKS 162
Cdd:PRK09165 91 LGELGGVQYLAKLATEAVTIINARDYGRIIYDLALRRELINIGEDVVNNAYdAPVDVAPQEQIEDAEQKLYELAETG-RY 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 163 TEGPQNLHSILEKTVDKIEELYQSPqDGVTGVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEHAA------ 236
Cdd:PRK09165 170 EGGFQSFGTAITEAVDMANAAFKRD-GHLSGISTGLRDLDSKLGGLHPSDLIILAGRPSMGKTALATNIAFNAAkayrre 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 237 MTQD--------KPVLIYSLEMPSEQIMMRMLASLGRINQTKVRTGQLDDDDWARLSSTMGLLmEKGKMYVDDASGLTPT 308
Cdd:PRK09165 249 AQPDgskkavngGVVGFFSLEMSAEQLATRILSEQSEISSSKIRRGKISEEDFEKLVDASQEL-QKLPLYIDDTPALSIS 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 309 DVRSRARRIARDHGgISMIMVDYLQLMRVPSL--SDNRTLEIAEISRSLKALAKELQCPVIALSQLNRTLEQRADKRPIN 386
Cdd:PRK09165 328 QLRARARRLKRQHG-LDLLVVDYLQLIRGSSKrsSDNRVQEISEITQGLKALAKELNIPVIALSQLSRQVEQRDDKRPQL 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 387 SDLRESGSIEQDADLIMFIYRDEVY------NEDSAE-----------KGVAEIIIGKQRNGPIGKVRLTFQGQFSRFDN 449
Cdd:PRK09165 407 SDLRESGSIEQDADVVMFVYREEYYlkrkepREGTPKheewqekmekvHNKAEVIIAKQRHGPTGTVKLAFESEFTRFGD 486
|
..
gi 937116724 450 YA 451
Cdd:PRK09165 487 LA 488
|
|
| PRK08506 |
PRK08506 |
replicative DNA helicase; Provisional |
16-447 |
5.98e-145 |
|
replicative DNA helicase; Provisional
Pssm-ID: 236278 [Multi-domain] Cd Length: 472 Bit Score: 422.50 E-value: 5.98e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 16 HSIEAEQSVLGGLMLDNQAFDRVAELVVAQDFYTRTHKLIFEAMVNLAEGGDPIDLITISESLEKNNQLSSvggfAYLAE 95
Cdd:PRK08506 5 YDLDIERAVLSSILFSPDKFEEIASVLEPKDFYLPAHQDIFEAMLKLHNEDEPIDEEFIRKKLPKDKKIDE----EILLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 96 IAkNTPSAANIDAYANIVRERAVIREMIGVANEIAEAGFSpEGRTSHDLLDFAESKVFKIAEQrsKSTEGPQNLHSILEK 175
Cdd:PRK08506 81 IL-ATNPIDNIEAYVEEIKEKSIKRELLSLANTIPEQAVE-EDQKSSDILDEVERELYSITNG--SNSEDFKDSKEVIES 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 176 TVDKIEELYQSPQDGVTGVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEHAAMtQDKPVLIYSLEMPSEQI 255
Cdd:PRK08506 157 TMEHIKKQKRLGNKDIIGLDTGFVELNKMTKGFNKGDLIIIAARPSMGKTTLCLNMALKALN-QDKGVAFFSLEMPAEQL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 256 MMRMLASLGRINQTKVRTGQLDDDDWARLSSTMGLLMEKgKMYVDDASGLTPTDVRSRARRIARDHGGISMIMVDYLQLM 335
Cdd:PRK08506 236 MLRMLSAKTSIPLQNLRTGDLDDDEWERLSDACDELSKK-KLFVYDSGYVNIHQVRAQLRKLKSQHPEIGLAVIDYLQLM 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 336 RVPSLSDNRTLEIAEISRSLKALAKELQCPVIALSQLNRTLEQRADKRPINSDLRESGSIEQDADLIMFIYRDEVYNE-- 413
Cdd:PRK08506 315 SGSGNFKDRHLQISEISRGLKLLARELDIPIIALSQLNRSLESRADKRPMLSDLRESGAIEQDADIILFVYRDDVYKEre 394
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 937116724 414 ------DSAEKGV--------------AEIIIGKQRNGPIGKVRLTFQGQFSRF 447
Cdd:PRK08506 395 ekekekKAKKEGKeerrihfqnksieeAEIIIGKNRNGPTGTVKLRFQKEFTRF 448
|
|
| PRK07773 |
PRK07773 |
replicative DNA helicase; Validated |
12-398 |
1.94e-142 |
|
replicative DNA helicase; Validated
Pssm-ID: 236093 [Multi-domain] Cd Length: 886 Bit Score: 429.56 E-value: 1.94e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 12 KVPPHSIEAEQSVLGGLMLDNQAFDRVAELVVAQDFYTRTHKLIFEAMVNLAEGGDPIDLITISESLEKNNQLSSVGGFA 91
Cdd:PRK07773 22 RQPPQDLAAEQSVLGGMLLSKEAIARVLERLRPGAFYRPAHQNIYDAILDLYGRGEPADLVTVAAELDRRGLLERIGGAP 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 92 YLAEIAKNTPSAANIDAYANIVRERAVIREMIGVANEIAEAGFSPEGRTShDLLDFAESKVFKIAEQRSKstEGPQNLHS 171
Cdd:PRK07773 102 YLHTLISTVPTAANADYYARIVAEKALLRRLIEAGTRIVQYGYAEGADVA-EVVDRAQAEIYDVTDRRLS--EDFVALED 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 172 ILEKTVDKIEELYQSPqDGVTGVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEHAAMTQDKPVLIYSLEMP 251
Cdd:PRK07773 179 LLQPTFDEIDAIASSG-GLARGVPTGFTELDAMTNGLHPGQLIIVAARPSMGKTTFGLDFARNCAIRHRLAVAIFSLEMS 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 252 SEQIMMRMLASLGRINQTKVRTGQLDDDDWARLSSTMGLLMEkGKMYVDDASGLTPTDVRSRARRIARDHgGISMIMVDY 331
Cdd:PRK07773 258 KEQLVMRLLSAEAKIKLSDMRSGRMSDDDWTRLARAMGEISE-APIFIDDTPNLTVMEIRAKARRLRQEA-NLGLIVVDY 335
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 937116724 332 LQLMRVPSLSDNRTLEIAEISRSLKALAKELQCPVIALSQLNRTLEQRADKRPINSDLRESGSIEQD 398
Cdd:PRK07773 336 LQLMTSGKKYENRQQEVSEISRHLKLLAKELEVPVVALSQLSRGVEQRTDKRPMLSDLRESGCLTGD 402
|
|
| PRK05636 |
PRK05636 |
replicative DNA helicase; Provisional |
14-451 |
2.12e-129 |
|
replicative DNA helicase; Provisional
Pssm-ID: 180177 [Multi-domain] Cd Length: 505 Bit Score: 383.81 E-value: 2.12e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 14 PPHSIEAEQSVLGGLMLDNQAFDRVAELVVAQDFYTRTHKLIFEAMVNLAEGGDPIDLITISESLEKNNQLSSVGGFAYL 93
Cdd:PRK05636 70 PPYDNEAEQGVLGAMLLSPDTVIDIVEVLTPEDFYRPAHQLIFQAIIDLFSDNKEIDPVIVAGRLDRTNDLERVGGAPYL 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 94 AEIAKNTPSAANIDAYANIVRERAVIREMIGVANEIAEAGFS-PEGRTSHDLLDFAESKVFKIAEqrSKSTEGPQNLHSI 172
Cdd:PRK05636 150 HTLIQSVPTAANARYYAEIVSEKAVLRRLVDAGTRVVQLGYEgDEGAEIDSVIDRAQQEVFAVSQ--KNQSEDYAVLADI 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 173 LEKTVDKIEELyqSPQDGV-TGVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEHAAMTQDKPVLIYSLEMP 251
Cdd:PRK05636 228 LDPTMDELEML--SSQGGIaTGIPTGFKDLDDLTNGLRGGQMIIVAARPGVGKSTLALDFMRSASIKHNKASVIFSLEMS 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 252 SEQIMMRMLASLGRINQTKVRTGQLDDDDWARLSSTMGLLmEKGKMYVDDASGLTPTDVRSRARRIARDHGgISMIMVDY 331
Cdd:PRK05636 306 KSEIVMRLLSAEAEVRLSDMRGGKMDEDAWEKLVQRLGKI-AQAPIFIDDSANLTMMEIRSKARRLKQKHD-LKLIVVDY 383
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 332 LQLMRVPSLSDNRTLEIAEISRSLKALAKELQCPVIALSQLNRTLEQRADKRPINSDLRESGSIEQDADLIMFIYRDEVY 411
Cdd:PRK05636 384 LQLMSSGKRVESRQQEVSEFSRQLKLLAKELDVPLIAISQLNRGPESRTDKRPQLADLRESGSLEQDADMVMLLYRPDSQ 463
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 937116724 412 NEDSAEKGVAEIIIGKQRNGPIGKVRLTFQGQFSRFDNYA 451
Cdd:PRK05636 464 DKDDERAGEADIILAKHRGGPIDTVQVAHQLHYSRFVDMA 503
|
|
| PRK06321 |
PRK06321 |
replicative DNA helicase; Provisional |
10-456 |
1.83e-118 |
|
replicative DNA helicase; Provisional
Pssm-ID: 180528 [Multi-domain] Cd Length: 472 Bit Score: 354.92 E-value: 1.83e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 10 TLKVPPHSIEAEQSVLGGLMLDNQAFDRVAELVVAQDFYTRTHKLIFEAMVNLAEGGDPIDLITISESLEKNNQLSSVGG 89
Cdd:PRK06321 12 QLLSPPNSKESEMIVLGCMLTSVNYLNLAANQLQEDDFYFLEHKIIFRVLQDAFKSDKPIDVHLAGEELKRRNQLNVIGG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 90 FAYLAEIAKNTPSAANIDAYANIVRERAVIREMIGVANEIaEAGFSPEGRTSHDLLDFAESKVFKIAEQRS--------- 160
Cdd:PRK06321 92 PSYLITLAEFAGTSAYIEEYAEIIRSKSILRKMIQTAKEI-EKKALEEPKDVATALDEAQNLLFKISQTTNlaqyvlvad 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 161 -----KSTEGPQNLHSILEKTvDKIEELYQSPQD-GVTGVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEH 234
Cdd:PRK06321 171 klkglTSSKDKPFLLQLQERQ-EAFQQSAQGDSSpMISGIPTHFIDLDKMINGFSPSNLMILAARPAMGKTALALNIAEN 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 235 AAMTQDKPVLIYSLEMPSEQIMMRMLASLGRINQTKVRTGQLDDDDWARLSSTMGLlMEKGKMYVDDASGLTPTDVRSRA 314
Cdd:PRK06321 250 FCFQNRLPVGIFSLEMTVDQLIHRIICSRSEVESKKISVGDLSGRDFQRIVSVVNE-MQEHTLLIDDQPGLKITDLRARA 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 315 RRIARDHGgISMIMVDYLQLMRVPSL---SDNRTLEIAEISRSLKALAKELQCPVIALSQLNRTLEQRADKRPINSDLRE 391
Cdd:PRK06321 329 RRMKESYD-IQFLIIDYLQLLSGSGNlrnSESRQTEISEISRMLKNLARELNIPILCLSQLSRKVEDRANHRPMMSDLRE 407
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 937116724 392 SGSIEQDADLIMFIYRDEVYNEDSaEKGVAEIIIGKQRNGPIGKVRLTFQGQFSRFDNYAGPAMD 456
Cdd:PRK06321 408 SGSIEQDSDLVMFLLRREYYDPND-KPGTAELIVAKNRHGSIGSVPLVFEKEFARFRNYAACEFP 471
|
|
| PRK06749 |
PRK06749 |
replicative DNA helicase; Provisional |
17-449 |
1.08e-99 |
|
replicative DNA helicase; Provisional
Pssm-ID: 168658 [Multi-domain] Cd Length: 428 Bit Score: 305.34 E-value: 1.08e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 17 SIEAEQSVLGGLMLDNQAFdRVAELVVAQdFYTRTHKLIFEAMVNLAEGGDPIDLITISESLEKNNqLSSVGGFAYLAEI 96
Cdd:PRK06749 5 NVEAEKTVLGSLLLDGELI-KECRLTEQY-FSMPVHKSIFQLMRKMEDEGQPIDLVTFTSRVDPNF-LKGIGGMEYFIGL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 97 AKNTPSAANIDAYANIVRERAVIREMIGVANE-----IAEAGFSPEGRTSHDLLDFAEskvfkiaeqrsKSTEGPQNLHS 171
Cdd:PRK06749 82 MDGVPTTSNFSYYEGLVRGAWKMYQAGVLGHKmgerlIAEKSEKIIGETITALCELEE-----------KDCVCEFDLKD 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 172 ILektVDKIEELYQSPQDgVTGVSTGYTDLDKMTAGMQPSDLIIVAARPSMGKTTFAMNLAEHAAMTQdKPVLIYSLEMP 251
Cdd:PRK06749 151 AL---VDLYEELHQDAKE-ITGIETGYTSLNKMTCGLQEGDFVVLGARPSMGKTAFALNVGLHAAKSG-AAVGLFSLEMS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 252 SEQIMMRMLASLGRINQTKVRTGQ--LDDDDWARLSSTMGLLMEKgKMYVDDASGLTPTDVRSRARRIARDHGGIS-MIM 328
Cdd:PRK06749 226 SKQLLKRMASCVGEVSGGRLKNPKhrFAMEDWEKVSKAFAEIGEL-PLEIYDNAGVTVQDIWMQTRKLKRKHGDKKiLII 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 329 VDYLQLMRV-PSLSDNRTLEIAEISRSLKALAKELQCPVIALSQLNRTLEQRADKRPINSDLRESGSIEQDADLIMFIYR 407
Cdd:PRK06749 305 VDYLQLITGdPKHKGNRFQEISEISRKLKLLARELNVCVVALSQLSRSVESRQDKRPLLSDLRETGQIEQDADVIMLMYR 384
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 937116724 408 DEVYNEDSAEKGVAEIIIGKQRNGPIGKVRLTFQGQFSRFDN 449
Cdd:PRK06749 385 EDYYDKETMQKEMTEIHVAKHRNGPVGSFKLRFLKEFGRFVE 426
|
|
| DnaB |
pfam00772 |
DnaB-like helicase N terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ... |
13-115 |
6.29e-44 |
|
DnaB-like helicase N terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This N-terminal domain is required both for interaction with other proteins in the primosome and for DnaB helicase activity.
Pssm-ID: 395624 [Multi-domain] Cd Length: 103 Bit Score: 149.31 E-value: 6.29e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 13 VPPHSIEAEQSVLGGLMLDNQAFDRVAELVVAQDFYTRTHKLIFEAMVNLAEGGDPIDLITISESLEKNNQLSSVGGFAY 92
Cdd:pfam00772 1 VPPHNIEAEQAVLGALLLDPEAIDEVADILKPEDFYDPAHRLIFEAILDLYDKGEPIDPVTVAEELEKKGKLEDVGGIAY 80
|
90 100
....*....|....*....|...
gi 937116724 93 LAEIAKNTPSAANIDAYANIVRE 115
Cdd:pfam00772 81 LAELAANVPSAANIEYYARIVKE 103
|
|
| PRK07773 |
PRK07773 |
replicative DNA helicase; Validated |
394-451 |
3.37e-21 |
|
replicative DNA helicase; Validated
Pssm-ID: 236093 [Multi-domain] Cd Length: 886 Bit Score: 96.74 E-value: 3.37e-21
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 937116724 394 SIEQDADLIMFIYRDEVYNEDSAEKGVAEIIIGKQRNGPIGKVRLTFQGQFSRFDNYA 451
Cdd:PRK07773 827 SIEQDADVVILLYRPDYYDRDDPRGGEAEFIVAKHRNGPTGTVTLAFQLHLSRFANLA 884
|
|
| RecA-like_Gp4D_helicase |
cd19483 |
RecA-like domain of Escherichia coli bacteriophage T7 Gp4D helicase; This family includes the ... |
214-431 |
5.06e-19 |
|
RecA-like domain of Escherichia coli bacteriophage T7 Gp4D helicase; This family includes the RecA-like domain of the Gp4D fragment of the Gene4 helicase-primase (Gp4) from bacteriophage T7. Gp4D (residues 241-566) is the minimal fragment of the Gp4 that forms hexameric rings, it contains the helicase domain and the linker connecting the helicase and primase domains. Helicases are ring-shaped oligomeric enzymes that unwind DNA at the replication fork; they couple NTP hydrolysis to the unwinding of nucleic acid duplexes into their component strands. This family belongs to the RecA-like NTPase superfamily which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.
Pssm-ID: 410891 [Multi-domain] Cd Length: 231 Bit Score: 85.70 E-value: 5.06e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 214 IIVAARPSMGKTTFAMNLAEHAAMTQDKPVLIYSLEMPSEQIMMRMLASLGRINQTKVRTGqlDDDDWARLSSTMGLLME 293
Cdd:cd19483 1 VTIGAGSGIGKSTIVRELAYHLITEHGEKVGIISLEESVEETAKGLAGKHLGKPEPLELPR--DDITEEEEDDAFDNELG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 294 KGKMYVDDASGLTPTDVRSRARRIARDHGGISMIMVDYLQ-LMRVPSLSDNRTlEIAEISRSLKALAKELQCPVIALSQL 372
Cdd:cd19483 79 SGRFFLYDHFGSLDWDNLKEKIRYMVKVLGCKVIVLDHLTiLVSGLDSSDERK-ELDEIMTELAALVKELGVTIILVSHL 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 937116724 373 NRTlEQRAD----KRPINSDLRESGSIEQDADLIMFIYRDEvYNEDSAEKGVAEIIIGKQRNG 431
Cdd:cd19483 158 RRP-GGGKGheegGEVSESDLRGSSAIAQLSDYVIGLERNK-QADDPVERNTTRVRVLKNRFT 218
|
|
| AAA_25 |
pfam13481 |
AAA domain; This AAA domain is found in a wide variety of presumed DNA repair proteins. |
213-375 |
1.09e-10 |
|
AAA domain; This AAA domain is found in a wide variety of presumed DNA repair proteins.
Pssm-ID: 463892 [Multi-domain] Cd Length: 193 Bit Score: 60.86 E-value: 1.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 213 LIIVAARPSMGKTTFAMNLAehAAMTQDKP------------VLIYSLEMPSEQIMMRMLASLgrinqtkvrtGQLDDDD 280
Cdd:pfam13481 35 LGLLAGAPGTGKTTLALDLA--AAVATGKPwlggprvpeqgkVLYVSAEGPADELRRRLRAAG----------ADLDLPA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 281 WARLSSTMGLLMekgkMYVDDASGLTPTDVRSRARRIARDHGGISMIMVDYLQLMRVPSLSDNRtlEIAEISRSLKALAK 360
Cdd:pfam13481 103 RLLFLSLVESLP----LFFLDRGGPLLDADVDALEAALEEVEDPDLVVIDPLARALGGDENSNS--DVGRLVKALDRLAR 176
|
170
....*....|....*
gi 937116724 361 ELQCPVIALSQLNRT 375
Cdd:pfam13481 177 RTGATVLLVHHVGKD 191
|
|
| 41 |
PHA02542 |
41 helicase; Provisional |
201-409 |
2.53e-10 |
|
41 helicase; Provisional
Pssm-ID: 222864 [Multi-domain] Cd Length: 473 Bit Score: 62.39 E-value: 2.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 201 LDKMT-AGMQPSDLIIVAARPSMGKTTFAMNLAEhAAMTQDKPVLIYSLEMPSEQIMMRMLASLGRINQTKvrtgqLDDD 279
Cdd:PHA02542 179 LNKITkGGAERKTLNVLLAGVNVGKSLGLCSLAA-DYLQQGYNVLYISMEMAEEVIAKRIDANLLDVSLDD-----IDDL 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 280 DWARLSSTMGLLMEK--GKMYVDD--ASGLTPTDVRS------RARRIARDhggisMIMVDYLQLM---RVPSLSDNRTL 346
Cdd:PHA02542 253 SKAEYKAKMEKLRSKtqGKLIIKQypTGGAHAGHFRAllnelkLKKNFKPD-----VIIVDYLGICassRLRVSSENSYT 327
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 937116724 347 EIAEISRSLKALAKELQCPVIALSQLNRTLEQRADkrPINSDLRESGSIEQDADLIMFIYRDE 409
Cdd:PHA02542 328 YVKAIAEELRGLAVEHDVVVWTAAQTTRSGWDSSD--VDMSDTAESAGLPATADFMLAVIETE 388
|
|
| RAD55 |
COG0467 |
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms]; |
194-413 |
2.36e-09 |
|
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
Pssm-ID: 440235 [Multi-domain] Cd Length: 221 Bit Score: 57.23 E-value: 2.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 194 VSTGYTDLDKMTA-GMQPSDLIIVAARPSMGKTTFAMNLAEHAAMtQDKPVLIYSLEMPSEQIMMRMlASLGrinqtkvr 272
Cdd:COG0467 2 VPTGIPGLDELLGgGLPRGSSTLLSGPPGTGKTTLALQFLAEGLR-RGEKGLYVSFEESPEQLLRRA-ESLG-------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 273 tgqLDDDDwarlsstmglLMEKGKMYVDDAS----GLTPTDVRSRARRIARDHgGISMIMVD----YLQLMRVPSlsdnr 344
Cdd:COG0467 72 ---LDLEE----------YIESGLLRIIDLSpeelGLDLEELLARLREAVEEF-GAKRVVIDslsgLLLALPDPE----- 132
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 937116724 345 tlEIAEISRSLKALAKELQCPVIALSQLnrtleqradkrPINSDLRESGSIEQDADLIMFIYRDEVYNE 413
Cdd:COG0467 133 --RLREFLHRLLRYLKKRGVTTLLTSET-----------GGLEDEATEGGLSYLADGVILLRYVELGGE 188
|
|
| PRK05973 |
PRK05973 |
replicative DNA helicase; Provisional |
210-390 |
2.17e-07 |
|
replicative DNA helicase; Provisional
Pssm-ID: 168322 [Multi-domain] Cd Length: 237 Bit Score: 51.57 E-value: 2.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 210 PSDLIIVAARPSMGKTTFAMNLAEhAAMTQDKPVLIYSLEMPSEQIMMRmLASLGRINQTKVRTGQLDDDDwaRLSSTmg 289
Cdd:PRK05973 63 PGDLVLLGARPGHGKTLLGLELAV-EAMKSGRTGVFFTLEYTEQDVRDR-LRALGADRAQFADLFEFDTSD--AICAD-- 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 290 llmekgkmYVddasgltptdvrsrARRIARDHGGiSMIMVDYLQLM----RVPSLSDNrtleiaeiSRSLKALAKELQCP 365
Cdd:PRK05973 137 --------YI--------------IARLASAPRG-TLVVIDYLQLLdqrrEKPDLSVQ--------VRALKSFARERGLI 185
|
170 180
....*....|....*....|....*
gi 937116724 366 VIALSQLNRTLEQRADKRPINSDLR 390
Cdd:PRK05973 186 IVFISQIDRSFDPSAKPLPDIRDVR 210
|
|
| KaiC-like |
cd01124 |
Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. ... |
194-380 |
9.50e-06 |
|
Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.
Pssm-ID: 410869 [Multi-domain] Cd Length: 222 Bit Score: 46.49 E-value: 9.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 194 VSTGYTDLDKMTAGMQPSD-LIIVAARPSMGKTTFAMNLAEhAAMTQDKPVLIYSLEMPSEQIMMRMlASLGrinqtkvr 272
Cdd:cd01124 1 VKTGIPGLDELLGGGIPKGsVTLLTGGPGTGKTLFGLQFLY-AGAKNGEPGLFFTFEESPERLLRNA-KSFG-------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 273 tgqlddDDWARLSstmgllmEKGKMYVDDAS-----GLTPTDVRSRARRIARDHgGISMIMVDYLQLMRVPSLSDNRtle 347
Cdd:cd01124 71 ------WDFDEME-------DEGKLIIVDAPpteagRFSLDELLSRILSIIKSF-KAKRVVIDSLSGLRRAKEDQMR--- 133
|
170 180 190
....*....|....*....|....*....|...
gi 937116724 348 IAEISRSLKALAKELQCPVIALSQLNRTLEQRA 380
Cdd:cd01124 134 ARRIVIALLNELRAAGVTTIFTSEMRSFLSSES 166
|
|
| AAA_33 |
pfam13671 |
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ... |
213-322 |
1.22e-04 |
|
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.
Pssm-ID: 463952 [Multi-domain] Cd Length: 143 Bit Score: 41.91 E-value: 1.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937116724 213 LIIVAARPSMGKTTFAMNLAEHAAMtqdkpVLIyslempSEQIMMRMLASLGRinQTKVRTGQLDDDDWARLSSTMGLLM 292
Cdd:pfam13671 1 LILLVGLPGSGKSTLARRLLEELGA-----VRL------SSDDERKRLFGEGR--PSISYYTDATDRTYERLHELARIAL 67
|
90 100 110
....*....|....*....|....*....|
gi 937116724 293 EKGKMYVDDASGLTPtDVRSRARRIARDHG 322
Cdd:pfam13671 68 RAGRPVILDATNLRR-DERARLLALAREYG 96
|
|
| |
