|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
15-393 |
1.06e-69 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 224.42 E-value: 1.06e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 15 FLAFWLARVFTASGFQMLTVAIGWHLYQLTGNVLDLGLVGLVEFAPRVLFMLHTGHVADRYDRRKVAALCQSLQGLIALA 94
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 95 LAVGSATDNVTRELIFALAFLLGATRSFEMPATQALLPNVVPPGLFPRAVAASASATQSATIVAPAVGGFLYAFGSI-WV 173
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPgGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 174 YGPTVALYAIACILTLSLQARGQVTQRGRASI--ESLLAGIRFIRSRPDIL-GAISLDLFAVLLGGATALLPVFAKDILL 250
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLllRDLREGLRYLRRSPLLRlLLLALALFALLGGALTVLLPLLAKEVLG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 251 TGPLGLGLLRSAPAVGALLMSLWLARFPFERNVGRTMFTAVGIFGVATIAFGLSTSFWFSLAVLVVLGAADMISMVIRSS 330
Cdd:cd06173 241 GGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 939367591 331 FVQLETPDEMRGRVSAVNGLFIGASNQLGEFESGVTAHWFGTVPAVVMGGVGTLLVTGVWIKL 393
Cdd:cd06173 321 LLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
8-397 |
2.44e-38 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 142.81 E-value: 2.44e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 8 LLRQHRPFLAFWLARVFTASGFQMLTVAIGWHLYQLTGNVLDLGLVGLVEFAPRVLFMLHTGHVADRYDRRKVAALCQSL 87
Cdd:PRK10489 12 LLKTHPAFRAVFIARFISIFGLGLLGVAVPVQIQMMTGSTLQVGLSVTLTGGAMFIGLMVGGVLADRYDRKKLILLARGT 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 88 QGLIALALAVGSATDNVTRELIFALAFLLGATRSFEMPATQALLPNVVPPGLFPRAVAASASATQSATIVAPAVGGFLYA 167
Cdd:PRK10489 92 CGLGFIGLALNAFLPEPSLLAIYLLGLWDGFFGSLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPALGGLLIA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 168 FGSI-WVYGPTVALYAIACILTLSLQARGQVTQRGRASIESLLAGIRFIRSRPDILGAISLDLFAVLLGGATALLPVFAK 246
Cdd:PRK10489 172 AGGVaWNYGLAAAGTFITLLPLLRLPALPPPPQPREHPLRSLLAGFRFLLASPVVGGIALLGGLLTMASAVRVLYPALAD 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 247 DILLTGPLGLGLLRSAPAVGALLMSL---WLARFpfeRNVGRTMFTAVGIFGVATIAFGLSTSFWFSLAVLVVLGAADMI 323
Cdd:PRK10489 252 EVWQMGAAQIGLLYAAVPLGAALGALtsgWLAHS---ARPGLLMLLSTLGSFLAVGLFGLMPMWILAVLCLALFGYLSAI 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 939367591 324 SMVIRSSFVQLETPDEMRGRVSAVNGLFIGASNQLGEFESGVTAHWFGTVPAVVMGGVGTLLVTGVWIKLFPTL 397
Cdd:PRK10489 329 SSLLQYTLLQTQTPDEMLGRINGLWTAQNVTGDAIGAALLGGLGAMMTPVASASASGFGLLIIGVLLLLVLGEL 402
|
|
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
15-359 |
1.58e-34 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 131.29 E-value: 1.58e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 15 FLAFWLARVFTASGFQMLTVAIGWHLYQLTGNVLDLGLVGLVEFAPRVLFMLHTGHVADRYDRRKVAALCQSLQGLIALA 94
Cdd:TIGR00900 1 FRLLFAAQLISLIGTAITQVALPLYVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMIGADLIRAVLVAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 95 LAVGSATDNVTRELIFALAFLLGATRSFEMPATQALLPNVVPPGLFPRAVAASASATQSATIVAPAVGGFLYAFGSI-WV 173
Cdd:TIGR00900 81 LPFVALLGGLNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIkWA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 174 YGPTVALYAIACILTLSL----QARGQVTQRGRASIESLLAGIRFIRSRPDILGAISLDLFAVLL--GGATALLPVFAKD 247
Cdd:TIGR00900 161 IWVDAVGFAISALLIVSVripeLAASEIQALSNAVLRDTREGIKFVLKNPLLRTLLLLALLFNLVfaPAIVALFPYVQSK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 248 ILLTGPLGLGLLRSAPAVGALLMSLWLARFPFERNVGRTMFTAVGIFGVATIAFGLSTSFWFSLAVL-VVLGAADMISMV 326
Cdd:TIGR00900 241 YLGRGSTHYGWVLAAFGLGALLGALLLGLLGRYFKRMALMTGAIFVIGLAILVVGLTPPNFPLFLVLwFAIGVGYGPINV 320
|
330 340 350
....*....|....*....|....*....|...
gi 939367591 327 IRSSFVQLETPDEMRGRVSAVNGLFIGASNQLG 359
Cdd:TIGR00900 321 PQGTLLQRRVPAELLGRVFGAQFSLSHAAWPLG 353
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
12-386 |
2.36e-22 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 98.67 E-value: 2.36e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 12 HRPFLAFWLARVFTASGFQMLTVAIGWHLYQLTGNVLDLGLVGLVEFAPRVLFMLHTGHVADRYDRRKVAALCQSLQGLI 91
Cdd:pfam05977 9 QGVFRVIWIASLASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 92 ALALAVGSATDNVTRELIFALAFLLGATRSFEMPATQALLPNVVPPGLFPRAVAASASATQSATIVAPAVGGFLYA-FGS 170
Cdd:pfam05977 89 STLLTLLAGLGLLSPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAaFGP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 171 IWVYGPTVALY--AIACILTLSLQARGQVTQRGRAsIESLLAGIRFIRSRPDIlGAISLDLFAVLLGGAT--ALLPVFAK 246
Cdd:pfam05977 169 AFTFALNALSYfaVIAALWRWKRAAPASPLPRERI-FGAVRAGLRFTAMSREL-RSVLVRAFAFGLSASAvwALLPLVAR 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 247 DILLTGPLGLGLLRSAPAVGALLMSLWLARFpfernvgRTMFTAVGIFGVATIAF-------GLSTSFWFSLAVLVVLGA 319
Cdd:pfam05977 247 DLLDGDAIFYGILLGAVGVGAILGALSLPRL-------RERLGSDRLVLLASVVTalvllslALAPNLWLAIPVLLLGGA 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 939367591 320 ADMISMVIRSSFVQLETPDEMRGRVSAVNGLFIGASNQLGEFESGVTAHWFGTVPAVVMGGVGTLLV 386
Cdd:pfam05977 320 AWITALTTLNVAVQLSVPRWVRGRALAVYQTVFFGGMAAGSWLWGAVAEALSVTGALLGAAAALLAG 386
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
10-358 |
1.18e-19 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 89.26 E-value: 1.18e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 10 RQHRPFLAFWLARVFTASGFQMLTVAIGWHLYQLTGNVLDLGLVGLVEFAPRVLFMLHTGHVADRYDRRKVAALCQSLQG 89
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 90 LIALALAVGSatdnvTRELIFALAFLLGATRSFEMPATQALLPNVVPPGLFPRAVAASASATQSATIVAPAVGGFLYAFG 169
Cdd:COG2814 87 LGSLLCALAP-----SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 170 SI-WVYGPTVALYAIACILTLSLQARGQVTQRGRASIESLlagiRFIRSRPDILGAISLDLFAVLLGGATALLPVFAKDI 248
Cdd:COG2814 162 GWrWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLR----ELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 249 LLTGPLGLGLLRSAPAVGALLMSLWLARFPFERNVGRTMFTAVGIFGVATIAFGLSTSFWFSLAVLVVLGAADMISMVIR 328
Cdd:COG2814 238 LGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLL 317
|
330 340 350
....*....|....*....|....*....|
gi 939367591 329 SSFVQLETPDEMRGRVSAVNGLFIGASNQL 358
Cdd:COG2814 318 QALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
15-393 |
1.06e-69 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 224.42 E-value: 1.06e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 15 FLAFWLARVFTASGFQMLTVAIGWHLYQLTGNVLDLGLVGLVEFAPRVLFMLHTGHVADRYDRRKVAALCQSLQGLIALA 94
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 95 LAVGSATDNVTRELIFALAFLLGATRSFEMPATQALLPNVVPPGLFPRAVAASASATQSATIVAPAVGGFLYAFGSI-WV 173
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPgGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 174 YGPTVALYAIACILTLSLQARGQVTQRGRASI--ESLLAGIRFIRSRPDIL-GAISLDLFAVLLGGATALLPVFAKDILL 250
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLllRDLREGLRYLRRSPLLRlLLLALALFALLGGALTVLLPLLAKEVLG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 251 TGPLGLGLLRSAPAVGALLMSLWLARFPFERNVGRTMFTAVGIFGVATIAFGLSTSFWFSLAVLVVLGAADMISMVIRSS 330
Cdd:cd06173 241 GGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 939367591 331 FVQLETPDEMRGRVSAVNGLFIGASNQLGEFESGVTAHWFGTVPAVVMGGVGTLLVTGVWIKL 393
Cdd:cd06173 321 LLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
8-397 |
2.44e-38 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 142.81 E-value: 2.44e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 8 LLRQHRPFLAFWLARVFTASGFQMLTVAIGWHLYQLTGNVLDLGLVGLVEFAPRVLFMLHTGHVADRYDRRKVAALCQSL 87
Cdd:PRK10489 12 LLKTHPAFRAVFIARFISIFGLGLLGVAVPVQIQMMTGSTLQVGLSVTLTGGAMFIGLMVGGVLADRYDRKKLILLARGT 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 88 QGLIALALAVGSATDNVTRELIFALAFLLGATRSFEMPATQALLPNVVPPGLFPRAVAASASATQSATIVAPAVGGFLYA 167
Cdd:PRK10489 92 CGLGFIGLALNAFLPEPSLLAIYLLGLWDGFFGSLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPALGGLLIA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 168 FGSI-WVYGPTVALYAIACILTLSLQARGQVTQRGRASIESLLAGIRFIRSRPDILGAISLDLFAVLLGGATALLPVFAK 246
Cdd:PRK10489 172 AGGVaWNYGLAAAGTFITLLPLLRLPALPPPPQPREHPLRSLLAGFRFLLASPVVGGIALLGGLLTMASAVRVLYPALAD 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 247 DILLTGPLGLGLLRSAPAVGALLMSL---WLARFpfeRNVGRTMFTAVGIFGVATIAFGLSTSFWFSLAVLVVLGAADMI 323
Cdd:PRK10489 252 EVWQMGAAQIGLLYAAVPLGAALGALtsgWLAHS---ARPGLLMLLSTLGSFLAVGLFGLMPMWILAVLCLALFGYLSAI 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 939367591 324 SMVIRSSFVQLETPDEMRGRVSAVNGLFIGASNQLGEFESGVTAHWFGTVPAVVMGGVGTLLVTGVWIKLFPTL 397
Cdd:PRK10489 329 SSLLQYTLLQTQTPDEMLGRINGLWTAQNVTGDAIGAALLGGLGAMMTPVASASASGFGLLIIGVLLLLVLGEL 402
|
|
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
15-359 |
1.58e-34 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 131.29 E-value: 1.58e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 15 FLAFWLARVFTASGFQMLTVAIGWHLYQLTGNVLDLGLVGLVEFAPRVLFMLHTGHVADRYDRRKVAALCQSLQGLIALA 94
Cdd:TIGR00900 1 FRLLFAAQLISLIGTAITQVALPLYVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMIGADLIRAVLVAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 95 LAVGSATDNVTRELIFALAFLLGATRSFEMPATQALLPNVVPPGLFPRAVAASASATQSATIVAPAVGGFLYAFGSI-WV 173
Cdd:TIGR00900 81 LPFVALLGGLNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIkWA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 174 YGPTVALYAIACILTLSL----QARGQVTQRGRASIESLLAGIRFIRSRPDILGAISLDLFAVLL--GGATALLPVFAKD 247
Cdd:TIGR00900 161 IWVDAVGFAISALLIVSVripeLAASEIQALSNAVLRDTREGIKFVLKNPLLRTLLLLALLFNLVfaPAIVALFPYVQSK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 248 ILLTGPLGLGLLRSAPAVGALLMSLWLARFPFERNVGRTMFTAVGIFGVATIAFGLSTSFWFSLAVL-VVLGAADMISMV 326
Cdd:TIGR00900 241 YLGRGSTHYGWVLAAFGLGALLGALLLGLLGRYFKRMALMTGAIFVIGLAILVVGLTPPNFPLFLVLwFAIGVGYGPINV 320
|
330 340 350
....*....|....*....|....*....|...
gi 939367591 327 IRSSFVQLETPDEMRGRVSAVNGLFIGASNQLG 359
Cdd:TIGR00900 321 PQGTLLQRRVPAELLGRVFGAQFSLSHAAWPLG 353
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
12-386 |
2.36e-22 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 98.67 E-value: 2.36e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 12 HRPFLAFWLARVFTASGFQMLTVAIGWHLYQLTGNVLDLGLVGLVEFAPRVLFMLHTGHVADRYDRRKVAALCQSLQGLI 91
Cdd:pfam05977 9 QGVFRVIWIASLASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 92 ALALAVGSATDNVTRELIFALAFLLGATRSFEMPATQALLPNVVPPGLFPRAVAASASATQSATIVAPAVGGFLYA-FGS 170
Cdd:pfam05977 89 STLLTLLAGLGLLSPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAaFGP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 171 IWVYGPTVALY--AIACILTLSLQARGQVTQRGRAsIESLLAGIRFIRSRPDIlGAISLDLFAVLLGGAT--ALLPVFAK 246
Cdd:pfam05977 169 AFTFALNALSYfaVIAALWRWKRAAPASPLPRERI-FGAVRAGLRFTAMSREL-RSVLVRAFAFGLSASAvwALLPLVAR 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 247 DILLTGPLGLGLLRSAPAVGALLMSLWLARFpfernvgRTMFTAVGIFGVATIAF-------GLSTSFWFSLAVLVVLGA 319
Cdd:pfam05977 247 DLLDGDAIFYGILLGAVGVGAILGALSLPRL-------RERLGSDRLVLLASVVTalvllslALAPNLWLAIPVLLLGGA 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 939367591 320 ADMISMVIRSSFVQLETPDEMRGRVSAVNGLFIGASNQLGEFESGVTAHWFGTVPAVVMGGVGTLLV 386
Cdd:pfam05977 320 AWITALTTLNVAVQLSVPRWVRGRALAVYQTVFFGGMAAGSWLWGAVAEALSVTGALLGAAAALLAG 386
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
10-358 |
1.18e-19 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 89.26 E-value: 1.18e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 10 RQHRPFLAFWLARVFTASGFQMLTVAIGWHLYQLTGNVLDLGLVGLVEFAPRVLFMLHTGHVADRYDRRKVAALCQSLQG 89
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 90 LIALALAVGSatdnvTRELIFALAFLLGATRSFEMPATQALLPNVVPPGLFPRAVAASASATQSATIVAPAVGGFLYAFG 169
Cdd:COG2814 87 LGSLLCALAP-----SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 170 SI-WVYGPTVALYAIACILTLSLQARGQVTQRGRASIESLlagiRFIRSRPDILGAISLDLFAVLLGGATALLPVFAKDI 248
Cdd:COG2814 162 GWrWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLR----ELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 249 LLTGPLGLGLLRSAPAVGALLMSLWLARFPFERNVGRTMFTAVGIFGVATIAFGLSTSFWFSLAVLVVLGAADMISMVIR 328
Cdd:COG2814 238 LGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLL 317
|
330 340 350
....*....|....*....|....*....|
gi 939367591 329 SSFVQLETPDEMRGRVSAVNGLFIGASNQL 358
Cdd:COG2814 318 QALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
18-359 |
4.43e-14 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 72.84 E-value: 4.43e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 18 FWLARVFTASGFQMLTVAIGWHLYQ-LTGNVLDLGLVGLVEFAPRVLFMLHTGHVADRYDRRKVAALCQSLQGLIALALA 96
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEdLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 97 VGSATdnvtrELIFALAFLLGATRSFEMPATQALLPNVVPPGLFPRAVAASASATQSATIVAPAVGGFLYAFGSI----W 172
Cdd:pfam07690 81 FASSL-----WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWraafL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 173 VYGPTVALYAIACILTLSLQARGQVTQRGRASIeSLLAGIRFIRSRPDILGAISLDLFAVLLGGATALLPVFAKDILLTG 252
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPESKRPKPAEEARL-SLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 253 PLGLGLLRSAPAVGALLMSL--WLARFPFERNVGRTMFTAVGIFGVATIAFGLSTSFWFSLAVLVVLGAADMISMVIRSS 330
Cdd:pfam07690 235 LLAGLLLGLGGLLGAIGRLLlgRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNA 314
|
330 340
....*....|....*....|....*....
gi 939367591 331 FVQLETPDEMRGRVSAVNGLFIGASNQLG 359
Cdd:pfam07690 315 LVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
18-394 |
6.22e-14 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 72.61 E-value: 6.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 18 FWLARVFTASGFQMLTVAIGWHLYQLTGNVLDLGLVGLVEFAPRVLFMLHTGHVADRYDRRKVAalcqsLQGLIALALAV 97
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLL-----LLGLLLLAVST 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 98 GSATDNVTRELIFALAFLLGATRSFEMPATQALLPNVVPPGLFPRAVAASASATQSATIVAPAVGGFLYAFGSI-WVYGP 176
Cdd:cd17325 76 LLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYrAPFLV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 177 TVALYAIACILTLS-LQARGQVTQRGRASIESLLAGIRFIRSRPDILGAISLD-LFAVLLGGATALLPVFAKDILLTGPL 254
Cdd:cd17325 156 CAALALLALVLALLlLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIfVLAFAFGALEPFLPLYAAELGGLSPA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 255 GLGLLRSAPAVGALLMSLWLARFPFERNVGRTMFTAVGIFGVATIAFGLSTSFWFSLAVLVVLGAADMISMVIRSSFVQL 334
Cdd:cd17325 236 QIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLAD 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 335 ETPDEMRGRVSAVNGLFIGASNQLGEFESGVTAHWFGTVPAVVMGGVGTLLVTGVWIKLF 394
Cdd:cd17325 316 IVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
69-391 |
3.30e-13 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 70.33 E-value: 3.30e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 69 GHVADRYDRRKVAALCQSLQGLIALALAVGSATdnvtrELIFALAFLLGATRSFEMPATQALLPNVVPPGLFPRAVAASA 148
Cdd:cd17329 56 GRLADRFGRKPVMLAGLLLRALGFALLGFAHSP-----WLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLY 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 149 SATQSATIVAPAVGGFLYAFGSIWVYGPTVALYAIACILTLSLQARGQVTQRGRASIESLLAGIRFIRSRPDILGAISLD 228
Cdd:cd17329 131 WAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASF 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 229 LFAVLLGGATALLPVFAKDILLTGPLGLGLLRSAPAVGALLMSLWLARFPFERNVGRTMFTAVGIFGVATIAFGLSTSFW 308
Cdd:cd17329 211 LISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLA 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 309 FSLAVLVVLGAADMISMVIRSSFVQLETPDEMRGRVSAVNGLFIGASNQLGEFESG-VTAHWFGTVPAVVMGGVGTLLVT 387
Cdd:cd17329 291 VLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGlLLDLLGPGLPWLILAALGLIAAA 370
|
....
gi 939367591 388 GVWI 391
Cdd:cd17329 371 LLLG 374
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
11-395 |
6.87e-13 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 70.72 E-value: 6.87e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 11 QHRPFLAFWLARVFTAS---GFQMLTVAIGWHLYQLTGNVLDLGLVGLVEFAPRVLFMLHTGHVADRYDRRKVAALCQSL 87
Cdd:PRK08633 7 KIIGFLPLLLTQFLNAFndlGHKILIQNTLIKAYDGSEQVILTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVKLF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 88 QGLIALALAVGSATDNVtrELIFALAFLLGATRSFEMPATQALLPNVVPPGLFPRAVAASASATQSATIVAPAVGGFLYA 167
Cdd:PRK08633 87 EVGLTLLIVLAYYLGWF--WLAFAVTFLLGAQSAIYSPAKYGIIPELVGKENLSRANGLLEAFTIVAILAGTALFSFLFE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 168 F----------GSIWVYGptVALYAIAC---ILTLSL----QARGQVTQRGRASIESLLAG-IRFIRSRPDI-LGAISLD 228
Cdd:PRK08633 165 SvngntpseilGRIAPAG--LVLLAVAVlglIFAYRLpkvpAAAPEVFDKKKYLFPKLLWRnLKLLRSDRVLwLAIIGLS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 229 LFAVLLGGATALLPVFAKDILLTG-PLGLGLLRSAPAVGALLMSLWLARfpFERNVGRTMFTAVGIFGVATIAFGLST-- 305
Cdd:PRK08633 243 YFWFISQLAQANFPAYAKEVLGLDnTFQVQYLLAASAIGIGIGSLLAGR--LSGRHIELGLVPLGALGLALSLFLLPTap 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 306 SFWFSLAVLVVLGAADMISMVIRSSFVQLETPDEMRGRVSAVNGLF--IGASNQLGefeSGVTAHWFGTVPAVVMG--GV 381
Cdd:PRK08633 321 SLASVLVLFFLFGFSAGLFIVPLNALIQFRAPEKELGKVLAANNFLqnVGMLLFLA---LTTLFSGLGLSPAGLFYliAL 397
|
410
....*....|....
gi 939367591 382 GTLLVTGVWIKLFP 395
Cdd:PRK08633 398 VTLIGTLYTLLLLP 411
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
58-393 |
1.35e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.04 E-value: 1.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 58 FAPRVLFMLHTGHVADRYDRRKVaaLCQSLqGLIALALAVGSATDNVTreLIFALAFLLGATRSFEMPATQALLPNVVPP 137
Cdd:cd17474 44 TLPAAVLMPVAGVLADRFGRKKV--LLPGL-LLFGIGGLLCGLSDSFA--LLLAGRALQGIGAAGLGPLALTLIGDLFEG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 138 GLFPRAVAASASATQSATIVAPAVGGFLYAFGSIWVYGPTVALYAIACILTLSLQaRGQVTQRGRASIESLLAGIRFIRS 217
Cdd:cd17474 119 GERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLL-PEPKEKAKSSSATKLRDLKKALRG 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 218 RPDILGAISLDLFAVLLGGATALLPVFAKDILLTGPLGLGLLRSAPAVGALLMSLWLARF-PFERNVGRTMFTAVGIFGV 296
Cdd:cd17474 198 RGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLlKKRFGARRILVIGLLLYAL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 297 ATIAFGLSTSFWFSLAVLVVLGAADMISMVIRSSFVQLETPDEMRGRVSAVNG--LFIGASnqLGEFESGVTAHWFGTVP 374
Cdd:cd17474 278 SLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNfvRFLGQA--VGPLLFGLLLEIFGLSA 355
|
330
....*....|....*....
gi 939367591 375 AVVMGGVGTLLVTGVWIKL 393
Cdd:cd17474 356 PFLVGAAIALAAAVLLALL 374
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
18-389 |
1.97e-08 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 55.90 E-value: 1.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 18 FWLARVFTASGFQMLTVAIGWHLYQLTGNVLDLGLVGLVEFAPRVLFMLHTGHVADRYDRRKVAALCQSLQGLIALALAV 97
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 98 gsatdNVTRELIFALAFLLGATRSFEMPATQALLPNVVPPGLFPRAVAASASATQSATIVAPAVGGFLYAFGS------I 171
Cdd:cd06174 81 -----APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGfgwravF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 172 WVYGPTVALYAIACILTLSLQARGQVTQRGRASIESLLAGIRFIRSRPDI-LGAISLDLFAVLLGGATALLPVFAKDILL 250
Cdd:cd06174 156 LIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLwLLLLAIFLVNLAYYSFSTLLPLFLLDLGG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 251 TGPLGLGLLRSAPAVGALLMSLWLARFpFERNVGRTMFTAVGIFGVA--TIAFGLSTSFWFSLAVLVVLGAADMISMVIR 328
Cdd:cd06174 236 LSVAVAGLLLSLFGLAGALGSLLLGLL-SDRLIGRKPLLLIGLLLMAlgLALLLLAPSLLLLLLLLLLLGFGLGGLLPLS 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 939367591 329 SSFVQLETPDEMRGRVSAVNGLFIGASNQLGEFESGVTAHWFGTVPAVVMGGVGTLLVTGV 389
Cdd:cd06174 315 FALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAI 375
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
19-386 |
2.58e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 55.29 E-value: 2.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 19 WLARVFTASGFQMLTVAIGWHLYQLTGNVLDLGLVGLVEFAPRVLFMLHTGHVADRYDRRKVAALcqslqGLIALALAVG 98
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLI-----GLLIFALATL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 99 SATDNVTRELIFALAFLLGATRSFEMPATQALLPNVVPPGLFPRAVAASASATQSATIVAPAVGGFLYAFGSIWVYGPTV 178
Cdd:cd17489 77 LYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 179 ALYAIACILTLSLqaRGQVTQRGRASIESLLAGIRFIRSRPDILGAISLDLFAVLLGGATALLPVFAKDILLTGPLGLGl 258
Cdd:cd17489 157 AVLALLALLLVFL--VKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFF- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 259 lrSAPAVGALLMSLWLARFPFERNVGRTMFTAVGIFGVATIAFGLSTSFWFSLAVLVVLGAADMISMVIRSSFVQLETPD 338
Cdd:cd17489 234 --TVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPP 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 939367591 339 EMRGRVSAVNGLFIGASNQLGEFESGVTAHWFGTVPAVVMGGVGTLLV 386
Cdd:cd17489 312 HRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLA 359
|
|
| PRK06814 |
PRK06814 |
acyl-[ACP]--phospholipid O-acyltransferase; |
52-404 |
1.99e-06 |
|
acyl-[ACP]--phospholipid O-acyltransferase;
Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 49.96 E-value: 1.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 52 LVGLVEFAPRVLFMLHTGHVADRYDRRKVAALCQSLQGLIALALAVGSATDNVTreLIFALAFLLGATRSFEMPATQALL 131
Cdd:PRK06814 56 LAGAVFILPFFIFSALAGQLADKYDKAKLAKILKFAEIGIAALAIYGFHLNSVP--LLFAALFLMGIHSALFGPIKYSIL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 132 PNVVPPGLFPRAVAASASATQSATIVAPAVGGFLYAFGSIWVYGPTVALYAIACILTLSLQARGQVTQRG----RASIES 207
Cdd:PRK06814 134 PDHLNKDELLGANALVEAGTFIAILLGTIIGGLATISGNFVILVALLMGIAVLGWLASLFIPKTGNAAPDlkidRNIIRS 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 208 LLAGIRFIRSRPDI------------LGAISLDLFAVL----LGG----ATALLPVFAKDILLTGPLGLGLLRSAPA--- 264
Cdd:PRK06814 214 TITLLKYAKADKRIwlailgiswfwlVGAVVLSQLPLLaketLGGdenvATLFLAVFSVGVAVGSFLASKLSEGRITlly 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 265 --VGALLMSLWLARFPFernVGRTMFTAVGIFgvATIAFGLST-SFWFSLAVLVVLGAADMISMVIRSSFVQLETPDEMR 341
Cdd:PRK06814 294 vpIGALLMGLFGLDLAF---ASSSVPAEPAQL--KSILVFLSKrHGWRILIDLFGLAAAGGLYIVPLFAALQAWANPAHR 368
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 939367591 342 GRVSAVNGLFIGASNQLGefeSGVTAHWFG---TVPAV-VMGGVGTLLVTGVWIKLFPTLAKRDRLH 404
Cdd:PRK06814 369 ARVIAANNVLNAAFMVAG---TIILALLQAlgfSIPWIiLFIALANLIVAILILRLLPTNLLRDIFS 432
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
9-138 |
2.08e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.43 E-value: 2.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 9 LRQHRPFLAFWLARVFTASGFQML-TVAIGWHLYQLTGNVLDLGLVGLVEFAPRVLFMLHTGHVADRYDRRKVAALCQSL 87
Cdd:COG2211 224 LLKNRPFLLLLLAYLLFFLALALVaALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLL 303
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 939367591 88 QGLIALALAVgSATDNVTreLIFALAFLLGATRSFEMPATQALLPNVVPPG 138
Cdd:COG2211 304 AALGLLLLFF-LGPGNLW--LLLVLAALAGIGLGAILVLPWAMLADVVDYD 351
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
2-303 |
3.11e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 45.57 E-value: 3.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 2 SDSAPQLLRQHRPFLAFWLARVFTASGFQMLTVAIGWHLYQLTGNVLDLGLVGLVEFAPRVLFMLHTGHVADRYDRRKVA 81
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 82 ALCQSLQGLIALALAVgsatdNVTRELIFALAFLLGATRSFEMPATQALLPNVVPPGLFPRAVAASASATQSATIVAPAV 161
Cdd:COG0477 83 LIGLLLFGLASLLCGL-----APSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 162 GGFL-YAFGSIWVYGPTVALYAIACILTLSLQARgqvtqRGRASIESLLAGIRFIRSRPDILGAISLDLFAVLLGGATAL 240
Cdd:COG0477 158 GGLLvAALGWRWIFLINAPLGLLALVLRLRLPES-----RGLLLALLALALAALLLAALALALLALLLLLLLLLLALLAL 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 939367591 241 LPVFAKDILLTGPLGLGLLRSAPAVGALLMSLWLARFPFERNVGRTMFTAVGIFGVATIAFGL 303
Cdd:COG0477 233 LLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
49-399 |
6.92e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.48 E-value: 6.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 49 DLGLVGLVEFAPRVLFMLHTGHVADRYDRRKVAALCQSLQGLIALALAVGSATdnvtrELIFALAFLLGATRSFEMPATQ 128
Cdd:COG2271 46 QLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSF-----WQLLLLRFLLGLGEAGFFPAAL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 129 ALLPNVVPPGLFPRAVAASASATQSATIVAPAVGGFLyafgsIWVYGPTVALYAIACILTLslqargqvtqrgrasiesl 208
Cdd:COG2271 121 KLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL-----LAAFGWRAAFLILGLPGLL------------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 209 LAGIRFIrsrpdiLGAISLDLFAVLLGGATALLPVFAKDILLTGPLGLGLLRSAPAVGALLMSLWLARFP--FERNVGRT 286
Cdd:COG2271 177 LALLRFW------LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSdrLGRRRKLV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 287 MFTAVGIFGVATIAFGLSTSFWFSLAVLVVLGAADMISMVIRSSFVQLETPDEMRGRVSAVNGLFIGASNQLGEFESGVT 366
Cdd:COG2271 251 LAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYL 330
|
330 340 350
....*....|....*....|....*....|...
gi 939367591 367 AHWFGTVPAVVMGGVGTLLVTGVWIKLFPTLAK 399
Cdd:COG2271 331 LDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
261-355 |
6.56e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.39 E-value: 6.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 261 SAPAVGALLMSLWLARFPFERNVGRTMFTAVGIFGVATIAFGLSTSFWFSLAVLVVLGAADMISMVIRSSFVQLETPDEM 340
Cdd:cd17477 38 SAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNEN 117
|
90
....*....|....*
gi 939367591 341 RGRVSAVNGLFIGAS 355
Cdd:cd17477 118 RGRVLGLYSTVLGLG 132
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
261-402 |
2.14e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.96 E-value: 2.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939367591 261 SAPAVGALLMSLWLARFPFERNVGRTMFTAVGIFGVATIAFGLSTSFWFSLAVLVVLGAADMISMVIRSSFVQLETPDEM 340
Cdd:COG2814 52 TAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPER 131
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 939367591 341 RGRVSAVNGLFIGASNQLGEFESGVTAHWFGTVPAVVMGGVGTLLVTGVWIKLFPTLAKRDR 402
Cdd:COG2814 132 RGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAAR 193
|
|
| |
