|
Name |
Accession |
Description |
Interval |
E-value |
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
162-668 |
8.54e-110 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 338.09 E-value: 8.54e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 162 LTASLGILVFSVLLWLVVARQIRRLITEPIYQLEELSRQVtREENYALRAEPGNEDEIGSLAEAFNTMLSRIEAREQQLK 241
Cdd:COG5000 8 LLLLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAV-AAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQREELE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 242 RARddsqeaydqaqglaeetrhtnrklelevqvrskiekkltgfqNYLNSIIDSMPSAMIALDEQLYVTQWNQEATALSG 321
Cdd:COG5000 87 ERR------------------------------------------RYLETILENLPAGVIVLDADGRITLANPAAERLLG 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 322 TTLDEALNQPIFLAFePMRSFLPQIRHTVERHSVTKIErvtwIKNDESRHYALTFYPLTGdagRGVVIRIDDITQrisle 401
Cdd:COG5000 125 IPLEELIGKPLEELL-PELDLAELLREALERGWQEEIE----LTRDGRRTLLVRASPLRD---DGYVIVFDDITE----- 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 402 emMVQSEKMLSVGGLAAGMAHEINNPLGAILHNVQNIRRRLSPELPKnveqaeadgidlaqvnhylDSREVPKLLDGIQQ 481
Cdd:COG5000 192 --LLRAERLAAWGELARRIAHEIKNPLTPIQLSAERLRRKLADKLEE-------------------DREDLERALDTIIR 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 482 AGARAAKIVSHMLNFSRLSSRQLSPCDLPALIDQAVEIasndfdLTVGFDFKGQHIIRQFDPELGPVPCIANELEQVLLN 561
Cdd:COG5000 251 QVDRLKRIVDEFLDFARLPEPQLEPVDLNELLREVLAL------YEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLIN 324
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 562 LLKNAAQAIhqrpegEEPGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFTTKEigQGTGLGLSVSYFIVTnNH 641
Cdd:COG5000 325 LLKNAIEAI------EEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKP--KGTGLGLAIVKKIVE-EH 395
|
490 500
....*....|....*....|....*..
gi 940391699 642 KGQMEVQSSLGTGTCFTLRLPLVANQV 668
Cdd:COG5000 396 GGTIELESRPGGGTTFTIRLPLAEEAE 422
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
286-663 |
7.20e-104 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 320.64 E-value: 7.20e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 286 QNYLNSIIDSMPSAMIALDEQLYVTQWNQEATALSGTTLDEALNQPIFLAFEPMRSFLPQIRHTVERHSVTKIERVTWI- 364
Cdd:COG3852 6 EELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSPLRELLERALAEGQPVTEREVTLRr 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 365 KNDESRHYALTFYPLTGDAGR-GVVIRIDDITQRISLEEMMVQSEKMLSVGGLAAGMAHEINNPLGAILHNVQNIRRRLS 443
Cdd:COG3852 86 KDGEERPVDVSVSPLRDAEGEgGVLLVLRDITERKRLERELRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAQLLERELP 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 444 PElpknveqaeadgidlaqvnhyldsrEVPKLLDGIQQAGARAAKIVSHMLNFSRLSSRQLSPCDLPALIDQAVEIASND 523
Cdd:COG3852 166 DD-------------------------ELREYTQLIIEEADRLNNLVDRLLSFSRPRPPEREPVNLHEVLERVLELLRAE 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 524 FDltvgfdfKGQHIIRQFDPELGPVPCIANELEQVLLNLLKNAAQAIhqrpegEEPGRIVLRTRLNP----------PWA 593
Cdd:COG3852 221 AP-------KNIRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAM------PEGGTITIRTRVERqvtlgglrprLYV 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 594 EIQVEDNGIGMSENVRKRTFEPFFTTKEigQGTGLGLSVSYFIVtNNHKGQMEVQSSLGTGTCFTLRLPL 663
Cdd:COG3852 288 RIEVIDNGPGIPEEILDRIFEPFFTTKE--KGTGLGLAIVQKIV-EQHGGTIEVESEPGKGTTFRIYLPL 354
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
385-664 |
1.84e-86 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 275.52 E-value: 1.84e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 385 RGVVIRIDDITQRISLEEMMVQSEKMLSVGGLAAGMAHEINNPLGAILHNVQNIRRRLSPELpknveqaeadgidlaqvn 464
Cdd:COG4191 114 RDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGNAELLRRRLEDEP------------------ 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 465 hylDSREVPKLLDGIQQAGARAAKIVSHMLNFSRLSSRQLSPCDLPALIDQAVEIASNDFDLtvgfdfKGQHIIRQFDPE 544
Cdd:COG4191 176 ---DPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKA------RGIEVELDLPPD 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 545 LGPVPCIANELEQVLLNLLKNAAQAIhqrpEGEEPGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFTTKEIGQ 624
Cdd:COG4191 247 LPPVLGDPGQLEQVLLNLLINAIDAM----EEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKPVGK 322
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 940391699 625 GTGLGLSVSYFIVTnNHKGQMEVQSSLGTGTCFTLRLPLV 664
Cdd:COG4191 323 GTGLGLSISYGIVE-KHGGRIEVESEPGGGTTFTITLPLA 361
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
271-664 |
5.81e-55 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 195.58 E-value: 5.81e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 271 EVQVRSKIEKKLTGFQNYLNSIIDSMPSAMIALDEQLYVTQWNQEATALSGTTLDEALNQPIFLAF--EPMRSFLPQIRH 348
Cdd:COG5809 125 DITERKRMEEALRESEEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIhsDDQENVAAFISQ 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 349 TVERHSVTKIERVTWIKNDESRHYALTFYPLTGDAGR-GVVIRIDDITQRISLEEMMVQSEKMLSVGGLAAGMAHEINNP 427
Cdd:COG5809 205 LLKDGGIAQGEVRFWTKDGRWRLLEASGAPIKKNGEVdGIVIIFRDITERKKLEELLRKSEKLSVVGELAAGIAHEIRNP 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 428 LGAIlhnvqnirrrlspelpKNVEQAEADGIDLAQvNHYLDSrevpkLLDGIQqagaRAAKIVSHMLNFSRLSSRQLSPC 507
Cdd:COG5809 285 LTSL----------------KGFIQLLKDTIDEEQ-KTYLDI-----MLSELD----RIESIISEFLVLAKPQAIKYEPK 338
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 508 DLPALIDQAVEIASNDFDLtvgfdfKGQHIIRQFDPELGPVPCIANELEQVLLNLLKNAAQAIhqrPEGeepGRIVLRTR 587
Cdd:COG5809 339 DLNTLIEEVIPLLQPQALL------KNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAM---PEG---GNITIETK 406
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 940391699 588 LNPPWA-EIQVEDNGIGMSENVRKRTFEPFFTTKEigQGTGLGLSVSYFIVTnNHKGQMEVQSSLGTGTCFTLRLPLV 664
Cdd:COG5809 407 AEDDDKvVISVTDEGCGIPEERLKKLGEPFYTTKE--KGTGLGLMVSYKIIE-EHGGKITVESEVGKGTTFSITLPIK 481
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
280-665 |
4.24e-52 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 190.18 E-value: 4.24e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 280 KKLTGFQNYLNSIIDSMPSAMIALDEQLYVTQWNQEATALSGTTLDEALNQPIFLAFEPMRSFLPQIRHTVERHSVTKIE 359
Cdd:PRK11360 255 QALRETRSLNELILESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSELFPPNTPFASPLLDTLEHGTEHVDL 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 360 RVTWIKNDESRHYALTFYPLTGDAGR--GVVIRIDDITQRISLEEMMVQSEKMLSVGGLAAGMAHEINNPLGAILHNVQN 437
Cdd:PRK11360 335 EISFPGRDRTIELSVSTSLLHNTHGEmiGALVIFSDLTERKRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGYVQI 414
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 438 IRRRlspelPKNVEQAEADGIDLAQVNhyldsrevpklldgiqqagaRAAKIVSHMLNFSRLSSRQLSPCDLPALIDQAV 517
Cdd:PRK11360 415 WRQQ-----TSDPPSQEYLSVVLREVD--------------------RLNKVIDQLLEFSRPRESQWQPVSLNALVEEVL 469
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 518 EIasndFDLTVGFDfkGQHIIRQFDPELGPVPCIANELEQVLLNLLKNAAQAIHQRpegeepGRIVLRTRLNPP-WAEIQ 596
Cdd:PRK11360 470 QL----FQTAGVQA--RVDFETELDNELPPIWADPELLKQVLLNILINAVQAISAR------GKIRIRTWQYSDgQVAVS 537
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 940391699 597 VEDNGIGMSENVRKRTFEPFFTTKEigQGTGLGLSVSYFIVtNNHKGQMEVQSSLGTGTCFTLRLPLVA 665
Cdd:PRK11360 538 IEDNGCGIDPELLKKIFDPFFTTKA--KGTGLGLALSQRII-NAHGGDIEVESEPGVGTTFTLYLPINP 603
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
275-664 |
2.44e-51 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 185.71 E-value: 2.44e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 275 RSKIEKKLTGFQNYLNSIIDSMPSAMIALDEQLYVTQWNQEATALSGTTLDEALNQPIFLAFEPM--RSFLPQIRHTVER 352
Cdd:COG5805 145 KKKIEEILQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLELLHPCdkEEFKERIESITEV 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 353 HSVTKIERvTWI-KNDESRHYALTFYPLTGDAGR--GVVIRIDDITQRISLEEMMVQSEKMLSVGGLAAGMAHEINNPLG 429
Cdd:COG5805 225 WQEFIIER-EIItKDGRIRYFEAVIVPLIDTDGSvkGILVILRDITEKKEAEELMARSEKLSIAGQLAAGIAHEIRNPLT 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 430 AILHNVQNIRrrlspelPKNVEQaeadgidlaqvNHYLDSrevpkLLDGIQqagaRAAKIVSHMLNFSRLSSRQLSPCDL 509
Cdd:COG5805 304 SIKGFLQLLQ-------PGIEDK-----------EEYFDI-----MLSELD----RIESIISEFLALAKPQAVNKEKENI 356
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 510 PALIDQAVEIASNDFDLtvgfdfKGQHIIRQFDPELGPVPCIANELEQVLLNLLKNAAQAIhqrPEGeepGRIVLRTRLN 589
Cdd:COG5805 357 NELIQDVVTLLETEAIL------HNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAM---PNG---GTITIHTEEE 424
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 940391699 590 PPWAEIQVEDNGIGMSENVRKRTFEPFFTTKEigQGTGLGLSVSYFIVtNNHKGQMEVQSSLGTGTCFTLRLPLV 664
Cdd:COG5805 425 DNSVIIRVIDEGIGIPEERLKKLGEPFFTTKE--KGTGLGLMVSYKII-ENHNGTIDIDSKVGKGTTFTITLPLS 496
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
302-663 |
2.02e-46 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 167.39 E-value: 2.02e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 302 ALDEQLYVTQWNQEATALSGTTLDEALNQPIFLAFEPMRSFLPQIRHTVERHSVTKIERVTWIKNDESRHYALTFYPLTG 381
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 382 DAGRGVVIRIDDITQRISLEEMMVQSEKMLSVggLAAGMAHEINNPLGAILHNVQNIRRRLSPElpknveqaeadgidla 461
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSR--FLANVSHELRTPLTAIRGYLELLLEELDEE---------------- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 462 qvnhyldsreVPKLLDGIQQAGARAAKIVSHMLNFSRLSSRQLS----PCDLPALIDQAVEiasndfDLTVGFDFKGQHI 537
Cdd:COG0642 143 ----------QREYLETILRSADRLLRLINDLLDLSRLEAGKLElepePVDLAELLEEVVE------LFRPLAEEKGIEL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 538 IRQFDPELGPVPCIANELEQVLLNLLKNAAQAihqrpeGEEPGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFF 617
Cdd:COG0642 207 ELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKY------TPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFF 280
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 940391699 618 TTKE--IGQGTGLGLSVSYFIVTnNHKGQMEVQSSLGTGTCFTLRLPL 663
Cdd:COG0642 281 RTDPsrRGGGTGLGLAIVKRIVE-LHGGTIEVESEPGKGTTFTVTLPL 327
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
293-664 |
1.42e-44 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 163.42 E-value: 1.42e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 293 IDSMPSAMIALDEQLYVTQWNQEATALSGTTLDEALNQPiflaFEPMRSFLPQiRHTVERHSVTKIERVTWIKNDESR-- 370
Cdd:COG5807 33 FDSILEFVFFIDSKGEILECNDFAEDLYGLSQNEYIGKT----FVEEKCILKD-EQLYNKEAFDRIEISYLTKNGEFDei 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 371 HYALtFYPLTGDAGRGVVIRidDITQRISLEEMMVQSEKMLSVGGLAAGMAHEINNPLGAILHNVQNIRRRLSPELPKnv 450
Cdd:COG5807 108 IYPI-YYKDGVILGLITVYR--DITKRKEAEDKLLRSEKLSVAGELAAGIAHEIRNPLTSIKGFLQLLQESREDSERE-- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 451 eqaeadgidlaqvnhyldsREVPKLLDGIQqagaRAAKIVSHMLNFSRLSSRQLSPCDLPALIDQAVEIASNDFDLtvgf 530
Cdd:COG5807 183 -------------------EYFNIIISEID----RINTIITELLVLSKPKKFNFKKLNLNDVLEDVIALLSTEAIL---- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 531 dfKGQHIIRQFDPELGPVPCIANELEQVLLNLLKNAAQAIhqrpegEEPGRIVLRTRLNPPWAEIQVEDNGIGMSENVRK 610
Cdd:COG5807 236 --KNISIKYDLADDEPVINGDKNQLKQVFINLIKNAIEAM------ETGGNITIKTYVEGDFVVISVKDEGIGIPEEVLE 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 940391699 611 RTFEPFFTTKEigQGTGLGLSVSYFIVtNNHKGQMEVQSSLGTGTCFTLRLPLV 664
Cdd:COG5807 308 KIGEPFFTTKE--EGTGLGLSICKKII-EEHNGTIEVESKPGKGTTFTIYLPLY 358
|
|
| T2SS_HK |
NF038348 |
histidine kinase; |
399-663 |
5.90e-44 |
|
histidine kinase;
Pssm-ID: 439642 [Multi-domain] Cd Length: 574 Bit Score: 166.66 E-value: 5.90e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 399 SLEE---MMVQSEKMLSVGGLAAGMAHEINNPLGAILHNVQNIRRRLSPELPKNVEQAEADG-------IDLAQVNHYLD 468
Cdd:NF038348 310 ELEEthvQLLQSEKLASIGQLAAGVAHEINNPIGFVSANLNTLKGWVHSLLDVIAAQEAATPahaaqtrAPLAAAGRDAD 389
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 469 ----SREVPKLLDGIQQAGARAAKIVSHMLNFSRLSSRQLSPCDLPALIDQAVEIASNDfdltvgFDFKGQhIIRQFDpE 544
Cdd:NF038348 390 ldyvRGDIMTLIDESIDGAMRVRRIVQDLRDFSRPSGDEWSFADLHAGLESTLNVVHNE------LKYKAD-VVREYG-D 461
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 545 LGPVPCIANELEQVLLNLLKNAAQAIHQRpegeepGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFTTKEIGQ 624
Cdd:NF038348 462 LPLVECNAAQLNQVFMNLLVNAAQAIPGR------GTITIRTTCDGDHASIAISDTGKGIPPDVMGRIFDPFFTTKPVGQ 535
|
250 260 270
....*....|....*....|....*....|....*....
gi 940391699 625 GTGLGLSVSYFIVtNNHKGQMEVQSSLGTGTCFTLRLPL 663
Cdd:NF038348 536 GTGLGLSISHGIV-EHHRGRIDVASEPGRGSTFTITLPV 573
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
402-666 |
5.38e-40 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 146.98 E-value: 5.38e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 402 EMMVQSEKMLSvgGLAAGMAHEINNPLGAILHNVQNIRRRLSpelpknveqaeadgidlaqvnhyLDSREVPKLLDGIQQ 481
Cdd:COG2205 7 EELEELERLKS--EFLANVSHELRTPLTSILGAAELLLDEED-----------------------LSPEERRELLEIIRE 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 482 AGARAAKIVSHMLNFSRLSSRQLS----PCDLPALIDQAVEIASNDFDLtvgfdfKGQHIIRQFDPELGPVPCIANELEQ 557
Cdd:COG2205 62 SAERLLRLIEDLLDLSRLESGKLSlelePVDLAELLEEAVEELRPLAEE------KGIRLELDLPPELPLVYADPELLEQ 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 558 VLLNLLKNAAQAihqrpeGEEPGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFTTKEIG--QGTGLGLSVSYF 635
Cdd:COG2205 136 VLANLLDNAIKY------SPPGGTITISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRgeGGTGLGLAIVKR 209
|
250 260 270
....*....|....*....|....*....|.
gi 940391699 636 IVTnNHKGQMEVQSSLGTGTCFTLRLPLVAN 666
Cdd:COG2205 210 IVE-AHGGTIWVESEPGGGTTFTVTLPLAES 239
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
264-666 |
1.87e-39 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 149.70 E-value: 1.87e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 264 TNRKLELEVQVRSKIEKKLTGFQNYLNSIIDSMPSAMIALDEQLYVTQWNQEATALSGTTLDEALNQPIFLAFEPMRSFL 343
Cdd:COG5002 25 LLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLIL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 344 PQIRHTVERHSVTKIERVTWIKNDESRHYALTFYPLTGDAGRGVVIRIDDITQRISLEEMmvQSEkmlsvggLAAGMAHE 423
Cdd:COG5002 105 LLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQM--RRE-------FVANVSHE 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 424 INNPLGAILHNVQNIRRRLspelpknveqaeadgidlaqvnhYLDSREVPKLLDGIQQAGARAAKIVSHMLNFSRLSSRQ 503
Cdd:COG5002 176 LRTPLTSIRGYLELLLDGA-----------------------ADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGE 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 504 LS----PCDLPALIDQAVEiasndfDLTVGFDFKGQHIIRQFDPELGPVPCIANELEQVLLNLLKNAAQAihqrpeGEEP 579
Cdd:COG5002 233 LKlekePVDLAELLEEVVE------ELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKY------TPEG 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 580 GRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFT-----TKEIGqGTGLGLSVSYFIVtNNHKGQMEVQSSLGTG 654
Cdd:COG5002 301 GTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRvdksrSRETG-GTGLGLAIVKHIV-EAHGGRIWVESEPGKG 378
|
410
....*....|..
gi 940391699 655 TCFTLRLPLVAN 666
Cdd:COG5002 379 TTFTITLPLARE 390
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
554-663 |
5.94e-36 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 130.62 E-value: 5.94e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 554 ELEQVLLNLLKNAAQAIhqrpegEEPGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFTTKEIGQGTGLGLSVS 633
Cdd:cd16943 3 QLNQVLLNLLVNAAQAM------EGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGTGLGLSLS 76
|
90 100 110
....*....|....*....|....*....|
gi 940391699 634 YFIVtNNHKGQMEVQSSLGTGTCFTLRLPL 663
Cdd:cd16943 77 YRII-QKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
395-673 |
1.09e-35 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 144.05 E-value: 1.09e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 395 TQRISLEEMMVQSEKMLSVGGLAAGMAHEINNPLGAILhnvqnirrrlspelpKNVEQAEADgidlaqvnhyLDSREVP- 473
Cdd:PRK13837 432 TERDALERRLEHARRLEAVGTLASGIAHNFNNILGAIL---------------GYAEMALNK----------LARHSRAa 486
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 474 KLLDGIQQAGARAAKIVSHMLNFSRLSSRQLSPCDLPALIDQAVEIASNDFDLTVGFDFkgqhiirQFDPELGPVPCIAN 553
Cdd:PRK13837 487 RYIDEIISAGARARLIIDQILAFGRKGERNTKPFDLSELVTEIAPLLRVSLPPGVELDF-------DQDQEPAVVEGNPA 559
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 554 ELEQVLLNLLKNAAQAIhqrpegEEPGRIVLR---------TRLN----PP--WAEIQVEDNGIGMSENVRKRTFEPFFT 618
Cdd:PRK13837 560 ELQQVLMNLCSNAAQAM------DGAGRVDISlsraklrapKVLShgvlPPgrYVLLRVSDTGAGIDEAVLPHIFEPFFT 633
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 940391699 619 TKeiGQGTGLGLSVSYFIVtNNHKGQMEVQSSLGTGTCFTLRLPLVAnQVSVQQQ 673
Cdd:PRK13837 634 TR--AGGTGLGLATVHGIV-SAHAGYIDVQSTVGRGTRFDVYLPPSS-KVPVAPQ 684
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
400-665 |
8.42e-34 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 134.88 E-value: 8.42e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 400 LEEMMVQSE--KMLSVGGLAAGMAHEINNPLGAILHNVQnirrRLSPELPKNVEQaeadgidlaqvnhyldsrevpKLLD 477
Cdd:COG5808 226 LERVIQEINtqKLELIGTFAASTAHEIRNPLTSIKGFIQ----LLQEKYPELEDQ---------------------KYFD 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 478 GIQQAGARAAKIVSHMLNFSRLSSRQLSPCDLPALIDQAVEIASNDFDLtvgfdfKGQHIIRQFDPELGPVPCIANELEQ 557
Cdd:COG5808 281 IIQEEIQRINQIVSEFLVLGKPTAKKLELDDLNELIEEILSIIDSEANL------KNIRVEKQSLDEPLHIKCDKDRIKQ 354
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 558 VLLNLLKNAAQAIhqrpegEEPGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFTTKEigQGTGLGLSVSYFIV 637
Cdd:COG5808 355 VLLNLIKNAIEAM------KEGGKLTISIENDDEKAVIEVIDNGEGIPEDIIDEIFEPFVTTKE--GGTGLGLSVCKRIV 426
|
250 260
....*....|....*....|....*...
gi 940391699 638 tNNHKGQMEVQSSLGTGTCFTLRLPLVA 665
Cdd:COG5808 427 -EMHGGEIDIESEEGKGTTFTIRLPLKK 453
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
387-664 |
7.78e-30 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 122.28 E-value: 7.78e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 387 VVIRIDDITQRISLEEMMVQSEKMLSVGGLAAGMAHEINNPLGAILHNVQNIR-RRLSPElpKNVEQAEadgIDLAQVNh 465
Cdd:COG5806 175 AVYLIENLIENILLRKELQRAEKLEVVSELAASIAHEVRNPLTVVRGFIQLLQePELSDE--KRKQYIR---IALEELD- 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 466 yldsrevpklldgiqqagaRAAKIVSHMLNFSRLSSRQLSPCDLPALIDQAVEI-----ASNDFDLTV----GFDFKGqh 536
Cdd:COG5806 249 -------------------RAEAIITDYLTFAKPQPEKLEKIDVSEELEHVIDVlspyaNMNNVEIQTelepGLYIEG-- 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 537 iirqfDPelgpvpciaNELEQVLLNLLKNAAQAIhqrPEGeepGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPF 616
Cdd:COG5806 308 -----DR---------QKLQQCLINIIKNGIEAM---PNG---GTLTIDVSIDKNKVIISIKDTGVGMTKEQLERLGEPY 367
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 940391699 617 FTTKEigQGTGLGLSVSYFIVtNNHKGQMEVQSSLGTGTCFTLRLPLV 664
Cdd:COG5806 368 FSTKE--KGTGLGTMVSYRII-EAMNGTIRVESEVGKGTTFTITLPLA 412
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
140-666 |
2.69e-29 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 122.20 E-value: 2.69e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 140 EPPGHLLLVASSELPPAFYTGTLTASLGILVFSVLLWLVVARQIRRLITEPIYQLEELSRQVTREENYALRAEPGNEDEI 219
Cdd:COG4251 12 LLLLLLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELAL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 220 GSLAEAFNTMLSRIEAREQQLKRARDDSQEAYDQAQGLAEETRHTNRKLELEVQVRskiekkltgFQNYLNSIIDSMPSA 299
Cdd:COG4251 92 VLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLAL---------ALLLLLLLLLLLLLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 300 MIALDEQLYVTQWNQEATALSGTTLDEALNQPIFLAFEPMRSFLPQIRHTVERHSVTKIERVTWIKNDESRHYALTFYPL 379
Cdd:COG4251 163 LLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 380 TGDAGRGVVIRIDDIT-QRISLEEMMVQSEKMLS-----VGGLAAGMAHEINNPLGAILHNVQNIRRRLSPELPknveqa 453
Cdd:COG4251 243 LLLLLLILVLELLELRlELEELEEELEERTAELErsneeLEQFAYVASHDLREPLRKISGFSQLLEEDYGDKLD------ 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 454 eadgidlAQVNHYLDSrevpklldgIQQAGARAAKIVSHMLNFSRLSSRQLS--PCDLPALIDQAVE-----IASNDFDL 526
Cdd:COG4251 317 -------EEGREYLER---------IRDAAERMQALIDDLLAYSRVGRQELEfePVDLNELLEEVLEdleprIEERGAEI 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 527 TVGfdfkgqhiirqfdpELGPVPCIANELEQVLLNLLKNAAQaiHQRPEgeEPGRIVLRTRLNPPWAEIQVEDNGIGMSE 606
Cdd:COG4251 381 EVG--------------PLPTVRGDPTLLRQVFQNLISNAIK--YSRPG--EPPRIEIGAEREGGEWVFSVRDNGIGIDP 442
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 940391699 607 NVRKRTFEPFFT--TKEIGQGTGLGLSVSYFIVTnNHKGQMEVQSSLGTGTCFTLRLPLVAN 666
Cdd:COG4251 443 EYAEKIFEIFQRlhSRDEYEGTGIGLAIVKKIVE-RHGGRIWVESEPGEGATFYFTLPKAPA 503
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
552-663 |
1.89e-28 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 109.66 E-value: 1.89e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 552 ANELEQVLLNLLKNAAQAihqrpeGEEPGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFTTKEI---GQGTGL 628
Cdd:smart00387 3 PDRLRQVLSNLLDNAIKY------TPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRsrkIGGTGL 76
|
90 100 110
....*....|....*....|....*....|....*
gi 940391699 629 GLSVSYFIVtNNHKGQMEVQSSLGTGTCFTLRLPL 663
Cdd:smart00387 77 GLSIVKKLV-ELHGGEISVESEPGGGTTFTITLPL 110
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
340-661 |
2.74e-28 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 119.78 E-value: 2.74e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 340 RSFLPQIRHTVERHSVTKIERVTWIKNDESRHYALTFYPLTGDAGRGVVIRID--DITQRISLEEMMVQSEKMLSVGGLA 417
Cdd:PRK13557 88 RATVAEVRDAIAERREIATEILNYRKDGSSFWNALFVSPVYNDAGDLVYFFGSqlDVSRRRDAEDALRQAQKMEALGQLT 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 418 AGMAHEINNPLGAILHNVQNIRRRLspelpknveqaEADGIDLAQVnhyldSREVpkllDGIQQAGARAAKIVSHMLNFS 497
Cdd:PRK13557 168 GGIAHDFNNLLQVMSGYLDVIQAAL-----------SHPDADRGRM-----ARSV----ENIRAAAERAATLTQQLLAFA 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 498 R---LSSRQLSpcdLPALIDQAVEIASNdfdlTVGFDFKgqhIIRQFDPELGPVPCIANELEQVLLNLLKNAAQAIhqrP 574
Cdd:PRK13557 228 RkqrLEGRVLN---LNGLVSGMGELAER----TLGDAVT---IETDLAPDLWNCRIDPTQAEVALLNVLINARDAM---P 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 575 EGeepGRIVLRTR------------LNPP---WAEIQVEDNGIGMSENVRKRTFEPFFTTKEIGQGTGLGLSVSYFIVTN 639
Cdd:PRK13557 295 EG---GRVTIRTRnveiededlamyHGLPpgrYVSIAVTDTGSGMPPEILARVMDPFFTTKEEGKGTGLGLSMVYGFAKQ 371
|
330 340
....*....|....*....|..
gi 940391699 640 NhKGQMEVQSSLGTGTcfTLRL 661
Cdd:PRK13557 372 S-GGAVRIYSEVGEGT--TVRL 390
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
397-672 |
5.95e-28 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 117.58 E-value: 5.95e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 397 RISLEEMMVQSEKMLSVGGLAAGMAHEINNPLGAIlhnvQNIRRRLSPELPKNVEQAEadgidLAQVNhyldSREVPKLl 476
Cdd:PRK10364 221 RQLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSI----KGLAKYFAERAPAGGEAHQ-----LAQVM----AKEADRL- 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 477 dgiqqagaraAKIVSHMLNFSRLSSRQLSPCDLPALIDQAVEIASNdfdltvgfDFKGQHIIRQF--DPELGPVPCIANE 554
Cdd:PRK10364 287 ----------NRVVSELLELVKPTHLALQAVDLNDLINHSLQLVSQ--------DANSREIQLRFtaNDTLPEIQADPDR 348
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 555 LEQVLLNLLKNAAQAIhqrPEGeepGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFTTKeiGQGTGLGLSVSY 634
Cdd:PRK10364 349 LTQVLLNLYLNAIQAI---GQH---GVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTK--AEGTGLGLAVVH 420
|
250 260 270
....*....|....*....|....*....|....*...
gi 940391699 635 FIVTnNHKGQMEVQSSLGTGTCFTLRLPLVANQVSVQQ 672
Cdd:PRK10364 421 NIVE-QHGGTIQVASQEGKGATFTLWLPVNITRRDPQG 457
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
555-661 |
3.79e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 100.22 E-value: 3.79e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 555 LEQVLLNLLKNAAQAIHQRPEGeepgRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFTTKEIGQGTGLGLSVSY 634
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKVENP----RIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISY 76
|
90 100
....*....|....*....|....*..
gi 940391699 635 FIVtNNHKGQMEVQSSLGTGTCFTLRL 661
Cdd:cd16976 77 GIV-EEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
555-662 |
4.67e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 100.15 E-value: 4.67e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 555 LEQVLLNLLKNAAQAIhqrPEGeepGRIVLRTR---------LNPP------WAEIQVEDNGIGMSENVRKRTFEPFFTT 619
Cdd:cd16919 1 LELAILNLAVNARDAM---PEG---GRLTIETSnqrvdadyaLNYRdlipgnYVCLEVSDTGSGMPAEVLRRAFEPFFTT 74
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 940391699 620 KEIGQGTGLGLSVSYFIVTNNhKGQMEVQSSLGTGTCFTLRLP 662
Cdd:cd16919 75 KEVGKGTGLGLSMVYGFVKQS-GGHLRIYSEPGVGTTVRIYLP 116
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
292-663 |
6.68e-24 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 103.62 E-value: 6.68e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 292 IIDSMPSAMIALDEQLYVTQWN--------QEATALSGTTLDEALnQPIFLAFEPMRSFLPQirhtveRHSVTKIErVTW 363
Cdd:PRK11073 12 ILNSLINSILLLDDDLAIHYANpaaqqllaQSSRKLFGTPLPELL-SYFSLNIELMRESLQA------GQGFTDNE-VTL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 364 IKNDESRHYALTFYPLTGDAgrgVVIRIDDITQRISLEEMMVQSEKMLSVGGLAAGMAHEINNPLGAILHNVQNIRRRL- 442
Cdd:PRK11073 84 VIDGRSHILSLTAQRLPEGM---ILLEMAPMDNQRRLSQEQLQHAQQVAARDLVRGLAHEIKNPLGGLRGAAQLLSKALp 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 443 SPELPKN----VEQAEadgidlaQVNHYLDsrevpKLLdGIQQAGARAAKIVSHMLNfsrlSSRQLSPCDLPALIDqave 518
Cdd:PRK11073 161 DPALTEYtkviIEQAD-------RLRNLVD-----RLL-GPQRPGTHVTESIHKVAE----RVVQLVSLELPDNVR---- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 519 iasndfdltvgfdfkgqhIIRQFDPELGPVPCIANELEQVLLNLLKNAAQAIhqrpeGEEPGRIVLRTR----------- 587
Cdd:PRK11073 220 ------------------LIRDYDPSLPELAHDPDQIEQVLLNIVRNALQAL-----GPEGGTITLRTRtafqltlhger 276
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 940391699 588 --LNppwAEIQVEDNGIGMSENVRKRTFEPFFTTKEigQGTGLGLSVSYFIVtNNHKGQMEVQSSLGTgTCFTLRLPL 663
Cdd:PRK11073 277 yrLA---ARIDIEDNGPGIPPHLQDTLFYPMVSGRE--GGTGLGLSIARNLI-DQHSGKIEFTSWPGH-TEFSVYLPI 347
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
268-664 |
5.36e-23 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 101.85 E-value: 5.36e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 268 LELEVQVRSKIEKKLTGFQNYLNSIIDSMPSAMIALDEQLYVTQWNQEATALSGTtldEALNQPIFLAFEPMRSFLPQIR 347
Cdd:COG3290 65 LLLLAALLLKLLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGL---DAIGRPIDEVLAEVLETGERDE 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 348 HTVERHSVTKIERVTWIKNDESRhyaltfypltgdagrGVVIRIDDITQRISLEEMMVQSEKMLSVggLAAgMAHEINNP 427
Cdd:COG3290 142 EILLNGRVLVVNRVPIRDDGRVV---------------GAVATFRDRTELERLEEELEGVKELAEA--LRA-QRHDFRNH 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 428 LGAILHnvqnirrrlspelpknveqaeadgidLAQVNHYldsrevpklldgiQQAGARAAKIVSHMLNFSRLSSRQLSPC 507
Cdd:COG3290 204 LHTISG--------------------------LLQLGEY-------------DEALEYIDEISEELQELIDSLLSRIGNP 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 508 DLPALIDQAVEIASN---DFDLTVGFDFKGQHIIrqfdpelgpvpciANELEQVLLNLLKNAAQAIHQRPEGEepGRIVL 584
Cdd:COG3290 245 VLAALLLGKAARARErgiDLTIDIDSDLPDLPLS-------------DTDLVTILGNLLDNAIEAVEKLPEEE--RRVEL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 585 RTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFTTKEiGQGTGLGLSVSYFIVtNNHKGQMEVQSSLGTGTCFTLRLPLV 664
Cdd:COG3290 310 SIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKL-GEGRGLGLALVKQIV-EKYGGTIEVESEEGEGTVFTVRLPKE 387
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
555-663 |
8.88e-23 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 93.59 E-value: 8.88e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 555 LEQVLLNLLKNAAQaiHQRPEGEepGRIVLRTrlnPPWAEIQVEDNGIGMSENVRKRTFEPFFTTKEIGQ-GTGLGLSVS 633
Cdd:pfam02518 6 LRQVLSNLLDNALK--HAAKAGE--ITVTLSE---GGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGgGTGLGLSIV 78
|
90 100 110
....*....|....*....|....*....|
gi 940391699 634 YFIVtNNHKGQMEVQSSLGTGTCFTLRLPL 663
Cdd:pfam02518 79 RKLV-ELLGGTITVESEPGGGTTVTLTLPL 107
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
555-663 |
8.75e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 90.63 E-value: 8.75e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 555 LEQVLLNLLKNAaqaIHQRPEGEepgrIVLRTRL-----NPPWAEIQVEDNGIGMSENVRKRTFEPFF-----TTKEIGq 624
Cdd:cd16922 1 LRQILLNLLGNA---IKFTEEGE----VTLRVSLeeeeeDGVQLRFSVEDTGIGIPEEQQARLFEPFSqadssTTRKYG- 72
|
90 100 110
....*....|....*....|....*....|....*....
gi 940391699 625 GTGLGLSVSYFIVtNNHKGQMEVQSSLGTGTCFTLRLPL 663
Cdd:cd16922 73 GTGLGLAISKKLV-ELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
555-662 |
2.36e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 86.30 E-value: 2.36e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 555 LEQVLLNLLKNAAQAIHQRPEgeEPGRIVLRTRLNPPWA-EIQVEDNGIGMSENVRKRTFEPFFTTKEigQGTGLGLSVS 633
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGC--ERRELTIRTSPADDRAvTISVKDTGPGIAEEVAGQLFDPFYTTKS--EGLGMGLSIC 76
|
90 100
....*....|....*....|....*....
gi 940391699 634 YFIVtNNHKGQMEVQSSLGTGTCFTLRLP 662
Cdd:cd16920 77 RSII-EAHGGRLSVESPAGGGATFQFTLP 104
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
390-662 |
3.08e-19 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 92.06 E-value: 3.08e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 390 RIDDITQRISLEEMMVQSEKMLSVGGLAAGMAHEINNPLGAILHNVQNIRRRLSPElpknveqaeadgiDLAQVNHYLDS 469
Cdd:COG4192 410 RKRIEKNLRQTQDELIQAAKMAVVGQTMTSLAHELNQPLNAMSMYLFSAKKALEQE-------------NYAQLPTSLDK 476
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 470 revpklldgIQQAGARAAKIVSHMLNFSRLSSRQLSPCDLPALIDQAVEIasndfdltVGFDFKGQHIIRQFDPELgPVP 549
Cdd:COG4192 477 ---------IEGLIERMDKIIKSLRQFSRKSDTPLQPVDLRQVIEQAWEL--------VESRAKPQQITLHIPDDL-MVQ 538
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 550 CIANELEQVLLNLLKNAAQAIhqrpegEEPGRIVLRTRLNPPWAEIQVEDNGIGMseNVRKRTFEPFFTTKEIgqGTGLG 629
Cdd:COG4192 539 GDQVLLEQVLVNLLVNALDAV------ATQPQISVDLLSNAENLRVAISDNGNGW--PLVDKLFTPFTTTKEV--GLGLG 608
|
250 260 270
....*....|....*....|....*....|...
gi 940391699 630 LSVSYFIVtNNHKGQMEVQSSLGTGTCFTLRLP 662
Cdd:COG4192 609 LSICRSIM-QQFGGDLYLASTLERGAMVILEFN 640
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
555-662 |
6.95e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 79.75 E-value: 6.95e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 555 LEQVLLNLLKNAAQAIhqrpeGEEPGRIVLRTR------LNPPW----AEIQVEDNGIGMSENVRKRTFEPFFTTKEigQ 624
Cdd:cd16918 1 LIQVFLNLVRNAAQAL-----AGSGGEIILRTRtqrqvtLGHPRhrlaLRVSVIDNGPGIPPDLQDTIFYPMVSGRE--N 73
|
90 100 110
....*....|....*....|....*....|....*...
gi 940391699 625 GTGLGLSVSYFIVtNNHKGQMEVQSSLGTgTCFTLRLP 662
Cdd:cd16918 74 GTGLGLAIAQNIV-SQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
552-662 |
1.46e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 72.96 E-value: 1.46e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 552 ANELEQVLLNLLKNAAQAIHQRPEGEEPGRIVLRTRLNPPWAeIQVEDNGIGMSENVRKRTFEPFFTTKEigQGTGLGLS 631
Cdd:cd16944 2 TTQISQVLTNILKNAAEAIEGRPSDVGEVRIRVEADQDGRIV-LIVCDNGKGFPREMRHRATEPYVTTRP--KGTGLGLA 78
|
90 100 110
....*....|....*....|....*....|.
gi 940391699 632 VSYFIVtNNHKGQMEVQSSLGTGTCFTLRLP 662
Cdd:cd16944 79 IVKKIM-EEHGGRISLSNREAGGACIRIILP 108
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
422-663 |
5.43e-15 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 78.92 E-value: 5.43e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 422 HEINNPLGAILHNVqnirrrlspELPKNVEqaeadgIDLAQVnhyldsrevpKLLDGIQQAGARAAKIVSHMLNFSRLSS 501
Cdd:PRK15347 407 HEIRTPLNGVLGAL---------ELLQNTP------LTAEQM----------DLADTARQCTLSLLAIINNLLDFSRIES 461
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 502 RQLS----PCDLPALIDQA-----VEIASNDFDLTVgfdFKGQHIIRQFDPElgpvpciANELEQVLLNLLKNAAQAIhq 572
Cdd:PRK15347 462 GQMTlsleETALLPLLDQAmltiqGPAQSKSLTLRT---FVGAHVPLYLHLD-------SLRLRQILVNLLGNAVKFT-- 529
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 573 rpegeEPGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFTTKEIGQGTGLGLSVSYFIvTNNHKGQMEVQSSLG 652
Cdd:PRK15347 530 -----ETGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQGTGLGLTIASSL-AKMMGGELTLFSTPG 603
|
250
....*....|.
gi 940391699 653 TGTCFTLRLPL 663
Cdd:PRK15347 604 VGSCFSLVLPL 614
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
393-674 |
1.95e-14 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 76.94 E-value: 1.95e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 393 DITQRI----SLEEMMV------QSEKMLsvgglAAGMAHEINNPLGAILHNVQNIRrrlSPELPKnveqaeadgidlaq 462
Cdd:PRK10841 422 DVSARVkmeeSLQEMAQaaeqasQSKSMF-----LATVSHELRTPLYGIIGNLDLLQ---TKELPK-------------- 479
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 463 vnhyldsrEVPKLLDGIQQAGARAAKIVSHMLNFSRLSSRQL--SPCDLPAlidQAV--EIASNDFDLTVgfdfKGQHII 538
Cdd:PRK10841 480 --------GVDRLVTAMNNSSSLLLKIISDILDFSKIESEQLkiEPREFSP---REVinHITANYLPLVV----KKRLGL 544
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 539 RQF-DPElgpVPCIAN----ELEQVLLNLLKNAAQAIHQrpegeepGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTF 613
Cdd:PRK10841 545 YCFiEPD---VPVALNgdpmRLQQVISNLLSNAIKFTDT-------GCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLF 614
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 940391699 614 EPFFttkEIG-------QGTGLGLSVSYFIVtNNHKGQMEVQSSLGTGTCFTLRLPLVANQVSVQQQV 674
Cdd:PRK10841 615 DPFF---QVGtgvqrnfQGTGLGLAICEKLI-NMMDGDISVDSEPGMGSQFTIRIPLYGAQYPQKKGV 678
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
420-665 |
2.85e-14 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 75.65 E-value: 2.85e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 420 MAHEINNPLGAIlhnvqnirrRLSPELPknveqaeADGIDLAQVNHYLDSrevpklldgIQQAGARAAKIVSHMLNFSRL 499
Cdd:PRK11100 263 LTHELKSPLAAI---------RGAAELL-------QEDPPPEDRARFTGN---------ILTQSARLQQLIDRLLELARL 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 500 SSRQ----LSPCDLPALIDQAVEIASNDFDltvgfdfkGQHIIRQFDPELGPVPCIANELEQVLLNLLKNAaqaIHQRPE 575
Cdd:PRK11100 318 EQRQelevLEPVALAALLEELVEAREAQAA--------AKGITLRLRPDDARVLGDPFLLRQALGNLLDNA---IDFSPE 386
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 576 GeepGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFTTKEIGQG---TGLGLSvsyFI--VTNNHKGQMEVQSS 650
Cdd:PRK11100 387 G---GTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYSLPRPANGrksTGLGLA---FVreVARLHGGEVTLRNR 460
|
250
....*....|....*
gi 940391699 651 LGTGTCFTLRLPLVA 665
Cdd:PRK11100 461 PEGGVLATLTLPRHF 475
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
561-662 |
3.03e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 68.85 E-value: 3.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 561 NLLKNAAQAIhqRPEGEEPGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFTTKEIGqGTGLGLSVSYFIVTnN 640
Cdd:cd16915 7 NLIDNALDAL--AATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQG-ERGIGLALVRQSVE-R 82
|
90 100
....*....|....*....|..
gi 940391699 641 HKGQMEVQSSLGTGTCFTLRLP 662
Cdd:cd16915 83 LGGSITVESEPGGGTTFSIRIP 104
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
277-490 |
1.36e-13 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 71.21 E-value: 1.36e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 277 KIEKKLTGFQNYLNSIIDSMPSAMIALDEQLYVTQWNQEATALSGTTLDEALNQPIFLAF--EPMRSFLPQIRHTVERHS 354
Cdd:COG2202 1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLppEDDDEFLELLRAALAGGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 355 VTKIERVTWIKNDESRHYALTFYPLTGDAGR--GVVIRIDDITQRISLEEMMVQSEKMLSVGGLAAGMAHEINNPLGAIL 432
Cdd:COG2202 81 VWRGELRNRRKDGSLFWVELSISPVRDEDGEitGFVGIARDITERKRAEEALRESEERLRLLVENAPDGIFVLDLDGRIL 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 940391699 433 HNVQNIRRRLSpelpknVEQAEADGIDLAQVNHYLDSREVPKLLDGIQQAGARAAKIV 490
Cdd:COG2202 161 YVNPAAEELLG------YSPEELLGKSLLDLLHPEDRERLLELLRRLLEGGRESYELE 212
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
555-662 |
3.70e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 63.11 E-value: 3.70e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 555 LEQVLLNLLKNAAQAIHQRPegeePGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPF--FTTKEIGQGTGLGLSV 632
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRR----PPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFqrLHSREEYEGTGVGLAI 76
|
90 100 110
....*....|....*....|....*....|
gi 940391699 633 SYFIVTNnHKGQMEVQSSLGTGTCFTLRLP 662
Cdd:cd16921 77 VRKIIER-HGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
552-662 |
7.29e-12 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 62.51 E-value: 7.29e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 552 ANELEQVLLNLLKNAAQAIhqrPEGeepGRIVLRTRL-NPPWAEIQVEDNGIGMSENVRKRTFEPFFTTKEIGQ----GT 626
Cdd:cd16925 2 AEKYERVVLNLLSNAFKFT---PDG---GRIRCILEKfRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTrahgGT 75
|
90 100 110
....*....|....*....|....*....|....*..
gi 940391699 627 GLGLS-VSYFIVTnnHKGQMEVQSSLGTGTCFTLRLP 662
Cdd:cd16925 76 GLGLSiVKEFVEL--HGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
555-663 |
1.18e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 61.68 E-value: 1.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 555 LEQVLLNLLKNAAQAIHQRPegeepgRIVLRTRLNppWAEIQVEDNGIGMSENVRKRTFEPFF-----TTKEIGqGTGLG 629
Cdd:cd16939 1 MARALDNLLRNALRYAHRTV------RIALLVSGG--RLTLIVEDDGPGIPAAARERVFEPFVrldpsRDRATG-GFGLG 71
|
90 100 110
....*....|....*....|....*....|....
gi 940391699 630 LSVSYFIVtNNHKGQMEVQSSLGTGTCFTLRLPL 663
Cdd:cd16939 72 LAIVHRVA-LWHGGHVECDDSELGGACFRLTWPR 104
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
551-662 |
5.01e-11 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 65.70 E-value: 5.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 551 IANELEQVLLNLLKNAAQAIHQRPEGEepgrIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFTTKeiGQGTGLGL 630
Cdd:PRK11086 430 QVHELITILGNLIENALEAVGGEEGGE----ISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYSTK--GSNRGVGL 503
|
90 100 110
....*....|....*....|....*....|....*
gi 940391699 631 svsyFIV---TNNHKGQMEVQSSLGTGTCFTLRLP 662
Cdd:PRK11086 504 ----YLVkqsVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| nifL_nitrog |
TIGR02938 |
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ... |
262-663 |
9.31e-11 |
|
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]
Pssm-ID: 131984 [Multi-domain] Cd Length: 494 Bit Score: 64.54 E-value: 9.31e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 262 RHTNRKLELEVQVRSKiekkltgfQNYLNSIIDSMPSAMIALDEQLYVTQWNQEATALSgTTLDEALNQPIFLAF----- 336
Cdd:TIGR02938 113 RDITELHRLEQVVANQ--------KLLIESVVDAAPVAFVLLDPTGRVILDNQEYKKLA-TDLRVKEPAHTVLDLlreaw 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 337 -EPMRSFLPQirHTVERHSVTKIERV------------TWIKNDESRhyALTFYPLTGDagRGVVIRIDDITQrisleem 403
Cdd:TIGR02938 184 rEALAENWPQ--QLAFSNREARFDRGggrparwlsctgSVIGMESDC--ADSFFCAAEQ--PYLLLTIADISN------- 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 404 MVQSEKMLSVGGLAAGMAHE-----INNPLGAILHNVQNirrrlspelPKNVEQAEADGIDlaqvnHYLDSREVPKLLDG 478
Cdd:TIGR02938 251 LREEQERARLSALQALMAEEerleaIRETLSAAIHRLQG---------PMNLISAAISVLQ-----RRGDDAGNPASAAM 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 479 IQQA--GARAA-----KIVSHMLNFSRLssrqlsPCDLPALIDQAVEIASNDFdLTVGfdfkgqhIIRQFDPELgPVPCI 551
Cdd:TIGR02938 317 LQQAlsAGREHmealrQVIPQSPQEIVV------PVNLNQILRDVITLSTPRL-LAAG-------IVVDWQPAA-TLPAI 381
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 552 ---ANELEQVLLNLLKNAAQAIHQRPEGEEPGRIVlrTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFTTK-EIGQGTG 627
Cdd:TIGR02938 382 lgrELQLRSLFKALVDNAIEAMNIKGWKRRELSIT--TALNGDLIVVSILDSGPGIPQDLRYKVFEPFFTTKgGSRKHIG 459
|
410 420 430
....*....|....*....|....*....|....*.
gi 940391699 628 LGLSVSYFIVtNNHKGQMEVQSSLGTGTCFTLRLPL 663
Cdd:TIGR02938 460 MGLSVAQEIV-ADHGGIIDLDDDYSEGCRIIVEFRV 494
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
418-663 |
5.59e-10 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 62.62 E-value: 5.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 418 AGMAHEINNPLGAILHNVQNIrrrlspelpknveqaeADGIDLAQVNHYLDSrevpklldgIQQAGARAAKIVSHMLNFS 497
Cdd:PRK11466 449 AAMSHEIRTPLYGILGTAQLL----------------ADNPALNAQRDDLRA---------ITDSGESLLTILNDILDYS 503
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 498 RLS--SRQLSPCDLP----ALIDQAVEIASN---DFDLTVGFDFKGQ-HIIRQFDPElgpvpcianELEQVLLNLLKNAA 567
Cdd:PRK11466 504 AIEagGKNVSVSDEPfeprPLLESTLQLMSGrvkGRPIRLATDIADDlPTALMGDPR---------RIRQVITNLLSNAL 574
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 568 QAIhqrpegeEPGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFTTKEIGQGTGLGLSVSYFIvTNNHKGQMEV 647
Cdd:PRK11466 575 RFT-------DEGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKRGGTGLGLTISSRL-AQAMGGELSA 646
|
250
....*....|....*.
gi 940391699 648 QSSLGTGTCFTLRLPL 663
Cdd:PRK11466 647 TSTPEVGSCFCLRLPL 662
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
503-665 |
8.87e-10 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 61.46 E-value: 8.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 503 QLSPCDLPALIDQAVEIASNDfdltvgfdfkGQHIIRQFDPELGPVPCIANELEQVLLNLLKNAAQAIHqrpegeepGRI 582
Cdd:PRK09467 290 PMEMADLNALLGEVIAAESGY----------EREIETALQPGPIEVPMNPIAIKRALANLVVNAARYGN--------GWI 351
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 583 VLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPfFTTKEI---GQGTGLGLSVSYFIVtNNHKGQMEVQSSLGTGTCFTL 659
Cdd:PRK09467 352 KVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQP-FTRGDSargSSGTGLGLAIVKRIV-DQHNGKVELGNSEEGGLSARA 429
|
....*.
gi 940391699 660 RLPLVA 665
Cdd:PRK09467 430 WLPLTT 435
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
555-662 |
1.93e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 55.15 E-value: 1.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 555 LEQVLLNLLKNAAQaiHQRpegeepGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPfFTTKEI---GQGTGLGLS 631
Cdd:cd16950 1 LKRVLSNLVDNALR--YGG------GWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQP-FYRGDNargTSGTGLGLA 71
|
90 100 110
....*....|....*....|....*....|.
gi 940391699 632 VSYFIVtNNHKGQMEVQSSLGTGTCFTLRLP 662
Cdd:cd16950 72 IVQRIS-DAHGGSLTLANRAGGGLCARIELP 101
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
421-662 |
2.29e-09 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 59.96 E-value: 2.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 421 AHEINNPLGAILHNVQnirrrlSPELPKNVEQAEADGIDLAQVNHYLDSR--EVPKLLDGIQQAGaraakivSHMLNFSR 498
Cdd:PRK09303 159 AHDLRTPLTAASLALE------TLELGQIDEDTELKPALIEQLQDQARRQleEIERLITDLLEVG-------RTRWEALR 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 499 LSSRQLspcDLPALIDQAVEiasndfDLTVGFDFKGQHIIRQFDPELGPVPCIANELEQVLLNLLKNAaqaIHQRPEGee 578
Cdd:PRK09303 226 FNPQKL---DLGSLCQEVIL------ELEKRWLAKSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNA---IKYTPEG-- 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 579 pGRIVL----RTRlnpPWAEIQVEDNGIGMSENVRKRTFEPFFTTKEIGQ--GTGLGLSVSYFIVtNNHKGQMEVQSSLG 652
Cdd:PRK09303 292 -GTITLsmlhRTT---QKVQVSICDTGPGIPEEEQERIFEDRVRLPRDEGteGYGIGLSVCRRIV-RVHYGQIWVDSEPG 366
|
250
....*....|
gi 940391699 653 TGTCFTLRLP 662
Cdd:PRK09303 367 QGSCFHFTLP 376
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
555-662 |
2.46e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 55.29 E-value: 2.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 555 LEQVLLNLLKNAAQaiHQRPEGEepgrIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFTTKEIGQ----GTGLGL 630
Cdd:cd16952 1 LRSAFSNLVSNAVK--YTPPSDT----ITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCrntgGTGLGL 74
|
90 100 110
....*....|....*....|....*....|..
gi 940391699 631 SVSYFIVtNNHKGQMEVQSSLGTGTCFTLRLP 662
Cdd:cd16952 75 AIVKHVM-SRHDARLLIASELGKGSRFTCLFP 105
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
555-662 |
4.73e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 54.21 E-value: 4.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 555 LEQVLLNLLKNAAQAihqrpegeepGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFTTK---EIGQGTGLGLs 631
Cdd:cd16948 10 IGQIVSNALKYSKQG----------GKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGEngrNFQESTGMGL- 78
|
90 100 110
....*....|....*....|....*....|...
gi 940391699 632 vsYFI--VTNNHKGQMEVQSSLGTGTCFTLRLP 662
Cdd:cd16948 79 --YLVkkLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
540-674 |
5.70e-09 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 59.18 E-value: 5.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 540 QFDPE-LGPVPCIA----NELEQVLLNLLKNAAQAIHQrpegeepGRIVLRTrlnppWAEIQ------VEDNGIGMSENV 608
Cdd:PRK11091 379 RFDLEpLLPLPHKVitdgTRLRQILWNLISNAVKFTQQ-------GGVTVRV-----RYEEGdmltfeVEDSGIGIPEDE 446
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 940391699 609 RKRTFEPFFTTKEI--GQ---GTGLGLSVSYFIVtNNHKGQMEVQSSLGTGTCFTL--RLPLVANQVSVQQQV 674
Cdd:PRK11091 447 LDKIFAMYYQVKDShgGKpatGTGIGLAVSKRLA-QAMGGDITVTSEEGKGSCFTLtiHAPAVAEEVEDAFDE 518
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
555-661 |
2.60e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 52.41 E-value: 2.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 555 LEQVLLNLLKNAaqaIHQRPEGeepGRIVLRTRlNPPWAEIQVEDNGIGMSENVRKRTFEPFF-TTKEIGQGTGLGLSVS 633
Cdd:cd16940 14 LFLLLRNLVDNA---VRYSPQG---SRVEIKLS-ADDGAVIRVEDNGPGIDEEELEALFERFYrSDGQNYGGSGLGLSIV 86
|
90 100
....*....|....*....|....*...
gi 940391699 634 YFIVtNNHKGQMEVQSSLGTGTCFTLRL 661
Cdd:cd16940 87 KRIV-ELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
419-666 |
8.25e-08 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 54.99 E-value: 8.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 419 GMAHEINNPLgailhnvqnIRRRLSPELPKNVEQAEADGI--DLAQVNhyldsrevpklldgiqqagaraaKIVSHMLNF 496
Cdd:PRK10604 218 GIAHELRTPL---------VRLRYRLEMSDNLSAAESQALnrDIGQLE-----------------------ALIEELLTY 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 497 SRLSSRQ----LSPCDLPA-LIDQAVEIASNDFDLTVGFDFKGQHIIRQFDPELgpvpcianeLEQVLLNLLKNAAQAIH 571
Cdd:PRK10604 266 ARLDRPQnelhLSEPDLPAwLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRL---------MERVLDNLLNNALRYAH 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 572 QRpegeepgrivLRTRL--NPPWAEIQVEDNGIGMSENVRKRTFEPFF-----TTKEIGqGTGLGLSVSYFIVTnNHKGQ 644
Cdd:PRK10604 337 SR----------VRVSLllDGNQACLIVEDDGPGIPPEERERVFEPFVrldpsRDRATG-GCGLGLAIVHSIAL-AMGGS 404
|
250 260
....*....|....*....|..
gi 940391699 645 MEVQSSLGTGTCFTLRLPLVAN 666
Cdd:PRK10604 405 VNCDESELGGARFSFSWPVWHN 426
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
279-409 |
8.78e-08 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 55.16 E-value: 8.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 279 EKKLTGFQNYLNSIIDSMPSAMIALDEQLYVTQWNQEATALSGTTLDEALNQPIFLAFEPmrSFLPQIRHTVERhsvtkI 358
Cdd:COG3829 3 ELELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELIPN--SPLLEVLKTGKP-----V 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 940391699 359 ERVTWIKNDESRHYALTFYPLTgDAGR--GVVIRIDDITQRISLEEMMVQSEK 409
Cdd:COG3829 76 TGVIQKTGGKGKTVIVTAIPIF-EDGEviGAVETFRDITELKRLERKLREEEL 127
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
289-394 |
1.11e-07 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 50.49 E-value: 1.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 289 LNSIIDSMPSAMIALDEQLYVTQWNQEATALSGTTLDEALNQPIF-LAFEPMRSFLPQIRHTVERH-SVTKIERVTWIKN 366
Cdd:pfam00989 3 LRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLdLIPEEDDAEVAELLRQALLQgEESRGFEVSFRVP 82
|
90 100 110
....*....|....*....|....*....|.
gi 940391699 367 DESRHYALTFYPLTGDAG---RGVVIRIDDI 394
Cdd:pfam00989 83 DGRPRHVEVRASPVRDAGgeiLGFLGVLRDI 113
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
577-666 |
1.48e-07 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 54.25 E-value: 1.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 577 EEPGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFTTKEigqGTGLGLS------VSYFivtnNHKGQMEVQSS 650
Cdd:COG2972 357 EGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGE---GRGIGLRnvrerlKLYY----GEEYGLEIESE 429
|
90
....*....|....*.
gi 940391699 651 LGTGTCFTLRLPLVAN 666
Cdd:COG2972 430 PGEGTTVTIRIPLEEE 445
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
486-663 |
2.37e-07 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 54.27 E-value: 2.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 486 AAKIVSHMLNFSRLSSRqlspcdlpaLIDQAvEIASNDFDL---------TVGFDFK-------GQHIIRQFDPELGPVP 549
Cdd:PRK10490 704 ASEIRQQVLNTTRLVNN---------LLDMA-RIQSGGFNLrkewltleeVVGSALQmlepglsGHPINLSLPEPLTLIH 773
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 550 CIANELEQVLLNLLKNAAQAIHQRPEgeepgrIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFT-TKEIG-QGTG 627
Cdd:PRK10490 774 VDGPLFERVLINLLENAVKYAGAQAE------IGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARgNKESAiPGVG 847
|
170 180 190
....*....|....*....|....*....|....*.
gi 940391699 628 LGLSVSYFIVTNnHKGQMEVQSSLGTGTCFTLRLPL 663
Cdd:PRK10490 848 LGLAICRAIVEV-HGGTIWAENRPEGGACFRVTLPL 882
|
|
| sensory_box |
TIGR00229 |
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ... |
288-403 |
2.43e-07 |
|
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]
Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 49.98 E-value: 2.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 288 YLNSIIDSMPSAMIALDEQLYVTQWNQEATALSGTTLDEALNQPIF-LAFEPMRSFLPQI--RHTVERHSVTKIERVTWI 364
Cdd:TIGR00229 4 RYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLeLIPEEDREEVRERieRRLEGEPEPVSEERRVRR 83
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 940391699 365 KNDESRHYALTFYPLTGDAGR-GVVIRIDDITQRISLEEM 403
Cdd:TIGR00229 84 KDGSEIWVEVSVSPIRTNGGElGVVGIVRDITERKEAEEA 123
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
555-662 |
4.32e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 49.00 E-value: 4.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 555 LEQVLLNLLKNAAQAIHqrpegeEPGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFTT----KEIGQGTGLGL 630
Cdd:cd16946 5 LQQLFVNLLENSLRYTD------TGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVessrNRASGGSGLGL 78
|
90 100 110
....*....|....*....|....*....|..
gi 940391699 631 SVSYFIVTNNHKGQMEVQSSLGtGTCFTLRLP 662
Cdd:cd16946 79 AICHNIALAHGGTISAEHSPLG-GLRLVLTLP 109
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
161-255 |
4.63e-07 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 52.71 E-value: 4.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 161 TLTASLGILVFSVLLWLVVARQIRRLITEPIYQLEELSRQVtrEENYALRAEPGNEDEIGSLAEAFNTMLSRIEA---RE 237
Cdd:COG2972 155 LRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKV--EKGDLVRLEVSGNDEIGILARSFNEMVERIKElieEV 232
|
90
....*....|....*...
gi 940391699 238 QQLKRARDDSQEAYDQAQ 255
Cdd:COG2972 233 YELELEKKEAELKALQAQ 250
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
485-662 |
7.58e-07 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 52.08 E-value: 7.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 485 RAAKIVSHMLNFSRLSSRQLSPCDLPalIDQAVEIASN-DF------DLTVGFDFKGQHIIRQFDPELgpvpcianeLEQ 557
Cdd:PRK09835 310 RMAKMVSDMLFLAQADNNQLIPEKKM--LDLADEVGKVfDFfeawaeERGVELRFVGDPCQVAGDPLM---------LRR 378
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 558 VLLNLLKNAaqaIHQRPEGEepgRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFF----TTKEIGQGTGLGLSVS 633
Cdd:PRK09835 379 AISNLLSNA---LRYTPAGE---AITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYrvdpSRQRKGEGSGIGLAIV 452
|
170 180
....*....|....*....|....*....
gi 940391699 634 YFIVTnNHKGQMEVQSSLgTGTCFTLRLP 662
Cdd:PRK09835 453 KSIVV-AHKGTVAVTSDA-RGTRFVISLP 479
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
555-662 |
7.62e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 48.34 E-value: 7.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 555 LEQVLLNLLKNAaqaIHQRPEgeEPGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFTTK----EIGQGTGLGL 630
Cdd:cd16953 1 LGQVLRNLIGNA---ISFSPP--DTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERpaneAFGQHSGLGL 75
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 940391699 631 SVSYFI--------VTNNHKgqmevQSSLGTGTCFTLRLP 662
Cdd:cd16953 76 SISRQIieahggisVAENHN-----QPGQVIGARFTVQLP 110
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
162-663 |
9.30e-07 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 51.83 E-value: 9.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 162 LTASLGILVFSVLLWLVVARQIRRLITEPIYQLEELSRQVTREENYALRAEPGNEDEIGSLAEAFNTMLSRIEAREQQLK 241
Cdd:COG3920 44 LALLLASALLALLALSAAALAAALAVALAAAVGAAAALLALLVLLLLLLLAAAALALALLLAALAGLLLLAALLLLRLVA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 242 RARDDSQEAYDQAQGLAEETRHTNRKLELEVQVRSKIEKKLTGFQNYLNSIIDSMPSAMIALDEQLYVTQWNQEATALSG 321
Cdd:COG3920 124 LLAALALLALLLLLLLLLAILALAELAVALAELAAALLLLAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLALL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 322 TTLDEALNQPIFLAFEPMRSFLPQIRHTVERHSVTKIERVTWIKNDESRHY--ALTFYPLTGDAGRGVVIRIDDITQRIS 399
Cdd:COG3920 204 LALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRARGLGRLLllLLLLLLLLRALLLLAAGIRLVITERKR 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 400 LEEMMVQSEKMLSVgglaagMAHEI-----NNplgaiLHNVQNIrrrlspelpknveqaeadgidLAQVNHYLDSREVPK 474
Cdd:COG3920 284 AEEELEASLEEKEL------LLRELhhrvkNN-----LQVVSSL---------------------LRLQARRADDPEARE 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 475 LLDGIQ---QAGARAakivsHmlnfSRLS-SRQLSPCDLPALIDQAVE-IASNDFDLTVGFDFKGQHIirQFDPELGpVP 549
Cdd:COG3920 332 ALEESQnriQALALV-----H----ELLYqSEDWEGVDLRDYLRELLEpLRDSYGGRGIRIELDGPDV--ELPADAA-VP 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 550 C--IANELeqvLLNLLKNAAqaihqrPEGEEpGRIVLRTRLNPPWAEIQVEDNGIGMSENVrkrtfepffttkEIGQGTG 627
Cdd:COG3920 400 LglILNEL---VTNALKHAF------LSGEG-GRIRVSWRREDGRLRLTVSDNGVGLPEDV------------DPPARKG 457
|
490 500 510
....*....|....*....|....*....|....*.
gi 940391699 628 LGLSVSYfIVTNNHKGQMEVQSSlgTGTCFTLRLPL 663
Cdd:COG3920 458 LGLRLIR-ALVRQLGGTLELDRP--EGTRVRITFPL 490
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
57-446 |
1.02e-06 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 51.81 E-value: 1.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 57 RLISSANLNERSLYSPADARALLKELKSYGPLRAAAIYDNDGERLEQMQQGESLQLPRHYKDLDSWRLTEFRSTQVITVP 136
Cdd:COG3850 12 LRLLLALLALLLLALLLLSLLALLLLLERTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLLLLLLLLAALLS 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 137 KGDEPPGHLLLVASSELPPAFYTGTLTASLGILVFSVLLWLVVARQIRRLITEPIYQLEELSRQVTREeNYALRAEPGNE 216
Cdd:COG3850 92 LLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARG-DFDARVPVSGR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 217 DEIGSLAEAFNTMLSRIEAREQQLKRARDDSQEAYDQAQGLAEETRHTNRKLELEVQVRSKIEKKLTGFQNYLNSIIDSM 296
Cdd:COG3850 171 DELGTLARAFNRMADELQELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAE 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 297 PSAMIALDEQLYVTQWNQEATALSGTTLDEALNQPIFLAFEPMRSFLPQIRHTVERHSVTKIERVTWIKNDESRHYALTF 376
Cdd:COG3850 251 SELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLL 330
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 377 YPLTGDAGRGVVIRIDDITQRISLEEMMVQSEKMLSVGGLAAGMAHEINNPLGAILHNVQNIRRRLSPEL 446
Cdd:COG3850 331 IALASVVAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQG 400
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
416-498 |
1.21e-06 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 46.05 E-value: 1.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 416 LAAGMAHEINNPLGAILHNVQNIRRRLspelpknveqaeadgidlaqvnhyLDSREVPKLLDGIQQAGARAAKIVSHMLN 495
Cdd:cd00082 7 FLANVSHELRTPLTAIRGALELLEEEL------------------------LDDEEQREYLERIREEAERLLRLINDLLD 62
|
...
gi 940391699 496 FSR 498
Cdd:cd00082 63 LSR 65
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
185-238 |
2.29e-06 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 44.93 E-value: 2.29e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 940391699 185 RLITEPIYQLEELSRQVTrEENYALRAEPGNEDEIGSLAEAFNTMLSRIEAREQ 238
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIA-DGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
555-648 |
2.34e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 46.68 E-value: 2.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 555 LEQVLLNLLKNAaqaIHQRPEGeepGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFTTKEIGQG---TGLGLS 631
Cdd:cd16945 5 LRQAINNLLDNA---IDFSPEG---GLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGqksTGLGLA 78
|
90
....*....|....*....
gi 940391699 632 vsyFI--VTNNHKGQMEVQ 648
Cdd:cd16945 79 ---FVqeVAQLHGGRITLR 94
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
555-669 |
2.45e-06 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 51.00 E-value: 2.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 555 LEQVLLNLLKNAAQ-----AIHQRPE--GEEPGRIVLRtrlnppwaeIQVEDNGIGMSENVRKRTFEPFfttkeiGQ--- 624
Cdd:PRK11107 409 LQQIITNLVGNAIKftesgNIDILVElrALSNTKVQLE---------VQIRDTGIGISERQQSQLFQAF------RQada 473
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 940391699 625 -------GTGLGLSVSYFIVtNNHKGQMEVQSSLGTGTCF--TLRLPLVANQVS 669
Cdd:PRK11107 474 sisrrhgGTGLGLVITQKLV-NEMGGDISFHSQPNRGSTFwfHLPLDLNPNPII 526
|
|
| HAMP |
pfam00672 |
HAMP domain; |
183-235 |
4.77e-06 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 44.15 E-value: 4.77e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 940391699 183 IRRLITEPIYQLEELSRQVtREENYALRAEPGNEDEIGSLAEAFNTMLSRIEA 235
Cdd:pfam00672 2 LARRILRPLRRLAEAARRI-ASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
296-394 |
5.76e-06 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 45.32 E-value: 5.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 296 MPSAMIALDEQLYVTQWNQEATALSGTTLDEALNQPIFLAFEP--MRSFLPQIRHTVERHSVTKIERVTWIKNDESRHYA 373
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPedREELRERLENLLSGGEPVTLEVRLRRKDGSVIWVL 80
|
90 100
....*....|....*....|...
gi 940391699 374 LTFYPLTGDAG--RGVVIRIDDI 394
Cdd:cd00130 81 VSLTPIRDEGGevIGLLGVVRDI 103
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
3-463 |
6.09e-06 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 49.34 E-value: 6.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 3 LRQRLENLPVGQKLLAALLVLMTTVLLVANLTFISAAYYISQEAMAPQALQTIGRLISSANLNERSLYSPADARALLKEL 82
Cdd:COG2770 54 LLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLA 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 83 KSYGPLRAAAIYDNDGERLEQMQQGESLQLPRHYKDLDSWRLTEFRSTQVITVPKGDEPPGHLLLVASseLPPAFYTGTL 162
Cdd:COG2770 134 LLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLV--VLLEAALAAL 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 163 TASLGILVFSVLLWLVVARQIRRLITEPIYQLEELSRQVTREeNYALRAEPGNEDEIGSLAEAFNTMLSRIEAREQQLKR 242
Cdd:COG2770 212 LLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAG-DLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEE 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 243 ARDDSQEAYDQAQGLAEETRHTNRKLELEVQVRSKIEKKLTGFQNYLNSIIDSMPSAMIALDEQLYVTQWNQEA-TALSG 321
Cdd:COG2770 291 EEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLAlELLLE 370
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 322 TTLDEALNQPIFLAFEPMRSFLPQIRHTVERHSVTKIERVTWIKNDESRHYALTFYPLTGDAGRGVVIRIDDITQRISLE 401
Cdd:COG2770 371 AELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAA 450
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 940391699 402 EMMVQSEKMLSVGGLAAGMAHEINNPLGAILHNVQNIRRRLSPELPKNVEQAEADGIDLAQV 463
Cdd:COG2770 451 AEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEELAEELLLL 512
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
294-397 |
7.57e-06 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 45.10 E-value: 7.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 294 DSMPSAMIALDEQLYVTQWNQEATALSGTTLDEALNQPIFLAFEP--MRSFLPQIRHTVERHSVTKIERVTwIKNDESRH 371
Cdd:pfam08448 2 DSLPDALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAELLPPedAARLERALRRALEGEEPIDFLEEL-LLNGEERH 80
|
90 100
....*....|....*....|....*...
gi 940391699 372 YALTFYPLTGDAGR--GVVIRIDDITQR 397
Cdd:pfam08448 81 YELRLTPLRDPDGEviGVLVISRDITER 108
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
188-233 |
9.03e-06 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 43.20 E-value: 9.03e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 940391699 188 TEPIYQLEELSRQVTrEENYALRAEPGNEDEIGSLAEAFNTMLSRI 233
Cdd:cd06225 1 TRPLRRLTEAARRIA-EGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
489-674 |
1.71e-05 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 48.19 E-value: 1.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 489 IVSHMLNFSRLSS--RQLSP--CDLPALIDQAVE-----IASNDFDLTVGFDFKGQHIIRqFDPElgpvpcianELEQVL 559
Cdd:PRK09959 764 LIGEILDVDKIESgnYQLQPqwVDIPTLVQNTCHsfgaiAASKSIALSCSSTFPDHYLVK-IDPQ---------AFKQVL 833
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 560 LNLLKNAAQAIHQrpegeepGRIVLRTRL-----NPPWAEIQVEDNGIGMSENVRKRTFEPFFTTKEIGQ--GTGLGLSV 632
Cdd:PRK09959 834 SNLLSNALKFTTE-------GAVKITTSLghiddNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQqtGSGLGLMI 906
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 940391699 633 SYFIVtNNHKGQMEVQSSLGTGTCFTLRLPlvanqVSVQQQV 674
Cdd:PRK09959 907 CKELI-KNMQGDLSLESHPGIGTTFTITIP-----VEISQQV 942
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
595-664 |
2.37e-05 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 47.23 E-value: 2.37e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 940391699 595 IQVEDNGIGMSENVRKRTFEPFFTT-----KEIGqGTGLGLSvsyfIVTN---NHKGQMEVQSS-LGtGTCFTLRLPLV 664
Cdd:PRK09470 386 ITVDDDGPGVPEEEREQIFRPFYRVdeardRESG-GTGLGLA----IVENaiqQHRGWVKAEDSpLG-GLRLTIWLPLY 458
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
555-663 |
2.85e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 43.47 E-value: 2.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 555 LEQVLLNLLKNAaqaIHQRPE------GEEPGRIVLRtrlnppwaeiqVEDNGIGMSENVRKRTFEPFFTTKEIGQ---- 624
Cdd:cd16949 1 LARALENVLRNA---LRYSPSkilldiSQDGDQWTIT-----------ITDDGPGVPEDQLEQIFLPFYRVDSARDresg 66
|
90 100 110
....*....|....*....|....*....|....*....
gi 940391699 625 GTGLGLSVSYFIVtNNHKGQMEVQSSLGTGTCFTLRLPL 663
Cdd:cd16949 67 GTGLGLAIAERAI-EQHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
289-353 |
2.95e-05 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 42.39 E-value: 2.95e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 940391699 289 LNSIIDSMPSAMIALDEQLYVTQWNQEATALSGTTLDEALNQPIFLAFEPmrSFLPQIRHTVERH 353
Cdd:smart00091 3 LRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHP--EDRERVQEALQRL 65
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
156-279 |
3.28e-05 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 46.94 E-value: 3.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 156 AFYTGTLTASLGILVFSVLLWLVVARQIRRLITEPIYQLEELSRQVTrEENYALRAEPGNEDEIGSLAEAFNTMLSRIEA 235
Cdd:COG0840 175 AAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIA-EGDLTVRIDVDSKDEIGQLADAFNRMIENLRE 253
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 940391699 236 REQQLKRA----RDDSQEAYDQAQGLAEETRHTNRKLElevQVRSKIE 279
Cdd:COG0840 254 LVGQVRESaeqvASASEELAASAEELAAGAEEQAASLE---ETAAAME 298
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
277-402 |
3.43e-05 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 46.17 E-value: 3.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 277 KIEKKLTGFQNYLNSIIDSMPSAMIALDEQLYVTQWNQEATALSGTTLDEALNQPIFLAFEPM--RSFLPQIRHTVERHS 354
Cdd:COG2202 127 RAEEALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEdrERLLELLRRLLEGGR 206
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 940391699 355 VT-KIERVTWIKNDESRHYALTFYPL-TGDAGRGVVIRIDDITQRISLEE 402
Cdd:COG2202 207 ESyELELRLKDGDGRWVWVEASAVPLrDGGEVIGVLGIVRDITERKRAEE 256
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
554-662 |
3.60e-05 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 44.88 E-value: 3.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 554 ELEQVLLNLLKNAA-QAIHQRPE----GEEP-GRIVLRTRLNPPWAEIQVEDNGIGMS-ENVRKRT-------------- 612
Cdd:cd16916 38 KLADPLTHLLRNAVdHGIEAPEErlaaGKPPeGTITLRAEHQGNQVVIEVSDDGRGIDrEKIREKAierglitadeaatl 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 940391699 613 ---------FEPFFTTKE-IGQ--GTGLGLSVsyfiVTNNHK---GQMEVQSSLGTGTCFTLRLP 662
Cdd:cd16916 118 sddevlnliFAPGFSTAEqVTDvsGRGVGMDV----VKRSIEslgGTIEVESEPGQGTTFTIRLP 178
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
553-660 |
4.21e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 43.22 E-value: 4.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 553 NELEQVLLNLLKNAAQaihQRPEGeepGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFTTKEI---GQGTGLG 629
Cdd:cd16975 3 LLLSRALINIISNACQ---YAPEG---GTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSrrsGGHYGMG 76
|
90 100 110
....*....|....*....|....*....|.
gi 940391699 630 LSVSYFIVtNNHKGQMEVQSSLGTGTCFTLR 660
Cdd:cd16975 77 LYIAKNLV-EKHGGSLIIENSQKGGAEVTVK 106
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
416-501 |
4.36e-05 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 41.81 E-value: 4.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 416 LAAGMAHEINNPLGAILHNVQNIRRRLSPElpknveqaeadgidlaqvnhyldsrEVPKLLDGIQQAGARAAKIVSHMLN 495
Cdd:pfam00512 5 FLANLSHELRTPLTAIRGYLELLRDEKLDE-------------------------EQREYLETILRSAERLLRLINDLLD 59
|
....*.
gi 940391699 496 FSRLSS 501
Cdd:pfam00512 60 LSRIEA 65
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
547-661 |
6.05e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 43.27 E-value: 6.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 547 PVPCIANE--LEQVLLNLLKNAAQAihqrpeGEEPGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFEPFFTTKEIG- 623
Cdd:cd16947 11 PIYANANTeaLQRILKNLISNAIKY------GSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRn 84
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 940391699 624 ---QGTGLGLSVSYFIvTNNHKGQMEVQSSLGTGTCFTLRL 661
Cdd:cd16947 85 sakQGNGLGLTITKRL-AESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
458-665 |
1.58e-04 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 43.84 E-value: 1.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 458 IDLAQVNHYLDSREVPKLLDGIQQAGARAAKIVSHMLnfSRLSSRQLSPCDLPALIDQAVEIASNDFDLTVGFDFKGQhi 537
Cdd:COG4585 76 LEAARRLLDADPEAAREELEEIRELAREALAELRRLV--RGLRPPALDDLGLAAALEELAERLLRAAGIRVELDVDGD-- 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 538 irqfDPELGPVpcIANELEQVLLNLLKNA---AQAihqrpegeepGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKrtfe 614
Cdd:COG4585 152 ----PDRLPPE--VELALYRIVQEALTNAlkhAGA----------TRVTVTLEVDDGELTLTVRDDGVGFDPEAAP---- 211
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 940391699 615 pffttkeigqGTGLGLS-----VSyfivtnNHKGQMEVQSSLGTGTCFTLRLPLVA 665
Cdd:COG4585 212 ----------GGGLGLRgmrerAE------ALGGTLTIGSAPGGGTRVRATLPLAA 251
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
531-667 |
2.28e-04 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 43.80 E-value: 2.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 531 DFKGQHIIRQFDPELGPVPCIANELEQVLLNLLKNAAQaihQRPEGeepGRIVLRTRLNPPWAEIQVEDNGIGMSENVRK 610
Cdd:PRK10755 224 EQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHR---YSPEG---STITIKLSQEDGGAVLAVEDEGPGIDESKCG 297
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 940391699 611 RTFEPFFTTKEIGQGTGLGLSVSYFIVtNNHKGQMEVQSSL-GTGTCFTLRLPLVANQ 667
Cdd:PRK10755 298 ELSKAFVRMDSRYGGIGLGLSIVSRIT-QLHHGQFFLQNRQeRSGTRAWVWLPKAQNV 354
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
533-661 |
2.87e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 41.46 E-value: 2.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 533 KGQHIIRQFDPELgPVPCIANELEQVLLNLLKNAAQAIHqrpegeepGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRT 612
Cdd:cd16954 17 KGVSISLDISPEL-RFPGERNDLMELLGNLLDNACKWCL--------EFVEVTARQTDGGLHLIVDDDGPGVPESQRSKI 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 940391699 613 FEPFFTTKEIGQGTGLGLSVSYFIVtNNHKGQMEVQSSLGTGTCFTLRL 661
Cdd:cd16954 88 FQRGQRLDEQRPGQGLGLAIAKEIV-EQYGGELSLSDSPLGGARFEVVF 135
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
416-501 |
5.90e-04 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 38.70 E-value: 5.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 416 LAAGMAHEINNPLGAILHNVQNIRRRlspelPKNVEQAEadgidlaqvnhyldsrevpkLLDGIQQAGARAAKIVSHMLN 495
Cdd:smart00388 5 FLANLSHELRTPLTAIRGYLELLLDT-----ELSEEQRE--------------------YLETILREAERLLRLINDLLD 59
|
....*.
gi 940391699 496 FSRLSS 501
Cdd:smart00388 60 LSRIEA 65
|
|
| PRK14083 |
PRK14083 |
HSP90 family protein; Provisional |
562-640 |
1.72e-03 |
|
HSP90 family protein; Provisional
Pssm-ID: 237603 [Multi-domain] Cd Length: 601 Bit Score: 41.47 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 562 LLKNAAQAIHQRPEGEE--PGRIVLRTRLNPPwAEIQVEDNGIGMSE-----------NVRKRTFEPFFTTKE-IGQ-GT 626
Cdd:PRK14083 31 LLQNAVDAITARRALDPtaPGRIRIELTDAGG-GTLIVEDNGIGLTEeevheflatigRSSKRDENLGFARNDfLGQfGI 109
|
90
....*....|....
gi 940391699 627 GLglsVSYFIVTNN 640
Cdd:PRK14083 110 GL---LSCFLVADE 120
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
595-663 |
2.83e-03 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 40.94 E-value: 2.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 595 IQVEDNGIGMS-ENVRKR-----------------------TFEPFFTTKE-IGQ--GTGLGLSVsyfiVTNN---HKGQ 644
Cdd:COG0643 324 IEVSDDGRGLDlEKIRAKaiekglitaeeaaalsdeellelIFAPGFSTAEeVTDlsGRGVGMDV----VKTNieaLGGT 399
|
90
....*....|....*....
gi 940391699 645 MEVQSSLGTGTCFTLRLPL 663
Cdd:COG0643 400 IEIESEPGKGTTFTLRLPL 418
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
287-338 |
2.89e-03 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 36.76 E-value: 2.89e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 940391699 287 NYLNSIIDSMPSAMIALDEQLYVTQWNQEATALSGTTLDEALNQPIFLAFEP 338
Cdd:pfam13188 1 ERLRALFESSPDGILVLDEGGRIIYVNPAALELLGYELLGELLGELLDLLDP 52
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
537-662 |
3.11e-03 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 38.86 E-value: 3.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 537 IIRQFDPELGpVPCIANELEQVLLNLLKNA--AQAIHQRPEGEEPGRIVLRTRLNPPWAEIQVEDNGIGMSENVRKRTFE 614
Cdd:cd16929 27 LEIEGDPSIR-FPYVPSHLYYILFELLKNAmrATVESHGDDSDDLPPIKVTVAKGDEDLTIKISDRGGGIPREDLARLFS 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 615 PFFTTKEIGQ-----------------GTGLGLSVS-----YFivtnnhKGQMEVQSSLGTGTCFTLRLP 662
Cdd:cd16929 106 YMYSTAPQPSlddfsdlisgtqpsplaGFGYGLPMSrlyaeYF------GGDLDLQSMEGYGTDVYIYLK 169
|
|
| HATPase_SpoIIAB-like |
cd16942 |
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ... |
538-660 |
4.69e-03 |
|
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.
Pssm-ID: 340418 [Multi-domain] Cd Length: 135 Bit Score: 37.90 E-value: 4.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 538 IRQFDPELGPVpciaNELEQVLLNLLKNAAqaIHQRpeGEEPGRIV-LRTRLNPPWAEIQVEDNGIGMsENVrKRTFEPF 616
Cdd:cd16942 26 VAQLDPTIDEL----TEIKTVVSEAVTNAI--IHGY--NNDPNGIVsISVIIEDGVVHLTVRDEGVGI-PDI-EEARQPL 95
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 940391699 617 FTTKEIGQGTGLGlsvsyFIVTNNHKGQMEVQSSLGTGTCFTLR 660
Cdd:cd16942 96 FTTKPELERSGMG-----FTIMENFMDEVIVESEVNKGTTVYLK 134
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
553-664 |
5.80e-03 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 39.82 E-value: 5.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940391699 553 NELEQVLLNLLKNAAQAIHQRPEGEEPGRIVLRTRLNPpwAEIQVEDNGIGMSENVRKRTFEPFFTTK--EIGQ-GTGLG 629
Cdd:PRK15053 431 TEFAAIVGNLLDNAFEASLRSDEGNKIVELFLSDEGDD--VVIEVADQGCGVPESLRDKIFEQGVSTRadEPGEhGIGLY 508
|
90 100 110
....*....|....*....|....*....|....*
gi 940391699 630 LSVSYfivTNNHKGQMEVQSSLGTGTCFTLRLPLV 664
Cdd:PRK15053 509 LIASY---VTRCGGVITLEDNDPCGTLFSIFIPKV 540
|
|
| |
