NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|941967792|ref|WP_055254322|]
View 

MULTISPECIES: VOC family protein [Pseudoalteromonas]

Protein Classification

VOC family protein( domain architecture ID 10163510)

vicinal oxygen chelate (VOC) family protein uses a metal center to coordinate a substrate, intermediate, or transition state through vicinal oxygen atoms

CATH:  3.10.180.10
PubMed:  21820381

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SgaA_N_like cd07247
N-terminal domain of Streptomyces griseus SgaA and similar domains; SgaA suppresses the growth ...
 7-115 8.50e-30

N-terminal domain of Streptomyces griseus SgaA and similar domains; SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.


:

Pssm-ID: 319911 [Multi-domain]  Cd Length: 114  Bit Score: 103.11  E-value: 8.50e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941967792   7 LNYVEFPACDLTATKSFFTNVFNWQFTDY---GPEYTAFS-GQGLDGGFFNAPLKSLTQHGAALLVFYSNDIHATYKKVA 82
Cdd:cd07247    1 PVWFELPTTDLERAKAFYGAVFGWTFEDEgdgGGDYALFTaGGGAVGGLMRAPEEVAGAPPGWLIYFAVDDLDAALARVE 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 941967792  83 QYGGKIVKPIFEFPG-GCRFHFTEPSGNEFAVWS 115
Cdd:cd07247   81 AAGGKVVVPPTDIPGgGRFAVFADPEGNRFGLWS 114
 
Name Accession Description Interval E-value
SgaA_N_like cd07247
N-terminal domain of Streptomyces griseus SgaA and similar domains; SgaA suppresses the growth ...
 7-115 8.50e-30

N-terminal domain of Streptomyces griseus SgaA and similar domains; SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.


Pssm-ID: 319911 [Multi-domain]  Cd Length: 114  Bit Score: 103.11  E-value: 8.50e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941967792   7 LNYVEFPACDLTATKSFFTNVFNWQFTDY---GPEYTAFS-GQGLDGGFFNAPLKSLTQHGAALLVFYSNDIHATYKKVA 82
Cdd:cd07247    1 PVWFELPTTDLERAKAFYGAVFGWTFEDEgdgGGDYALFTaGGGAVGGLMRAPEEVAGAPPGWLIYFAVDDLDAALARVE 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 941967792  83 QYGGKIVKPIFEFPG-GCRFHFTEPSGNEFAVWS 115
Cdd:cd07247   81 AAGGKVVVPPTDIPGgGRFAVFADPEGNRFGLWS 114
VOC COG3324
Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function ...
 4-118 1.77e-25

Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function prediction only];


Pssm-ID: 442553 [Multi-domain]  Cd Length: 119  Bit Score: 92.39  E-value: 1.77e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941967792   4 HEKLNYVEFPACDLTATKSFFTNVFNWQFTDY---GPEYTAFS-GQGLDGGFFNAPLKSLTQHgaALLVFYSNDIHATYK 79
Cdd:COG3324    2 PGTIVWVELPVDDLERAKAFYEEVFGWTFEDDagpGGDYAEFDtDGGQVGGLMPGAEEPGGPG--WLLYFAVDDLDAAVA 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 941967792  80 KVAQYGGKIVKPIFEFPG-GCRFHFTEPSGNEFAVWSEKQ 118
Cdd:COG3324   80 RVEAAGGTVLRPPTDIPPwGRFAVFRDPEGNRFGLWQPAA 119
Glyoxalase pfam00903
Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;
6-113 1.90e-13

Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;


Pssm-ID: 395724 [Multi-domain]  Cd Length: 121  Bit Score: 61.70  E-value: 1.90e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941967792    6 KLNYVEFPACDLTATKSFFTNVFNWQF---TDYGPEYTAFSGQGLDGG-----FFNA----PLKSLTQHGAALLVFYSND 73
Cdd:pfam00903   1 RIDHVALRVGDLEKSLDFYTDVLGFKLveeTDAGEEGGLRSAFFLAGGrvlelLLNEtpppAAAGFGGHHIAFIAFSVDD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 941967792   74 IHATYKKVAQYGGKIVKPIFEFPGGCR-FHFTEPSGNEFAV 113
Cdd:pfam00903  81 VDAAYDRLKAAGVEIVREPGRHGWGGRySYFRDPDGNLIEL 121
 
Name Accession Description Interval E-value
SgaA_N_like cd07247
N-terminal domain of Streptomyces griseus SgaA and similar domains; SgaA suppresses the growth ...
 7-115 8.50e-30

N-terminal domain of Streptomyces griseus SgaA and similar domains; SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.


Pssm-ID: 319911 [Multi-domain]  Cd Length: 114  Bit Score: 103.11  E-value: 8.50e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941967792   7 LNYVEFPACDLTATKSFFTNVFNWQFTDY---GPEYTAFS-GQGLDGGFFNAPLKSLTQHGAALLVFYSNDIHATYKKVA 82
Cdd:cd07247    1 PVWFELPTTDLERAKAFYGAVFGWTFEDEgdgGGDYALFTaGGGAVGGLMRAPEEVAGAPPGWLIYFAVDDLDAALARVE 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 941967792  83 QYGGKIVKPIFEFPG-GCRFHFTEPSGNEFAVWS 115
Cdd:cd07247   81 AAGGKVVVPPTDIPGgGRFAVFADPEGNRFGLWS 114
VOC COG3324
Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function ...
 4-118 1.77e-25

Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function prediction only];


Pssm-ID: 442553 [Multi-domain]  Cd Length: 119  Bit Score: 92.39  E-value: 1.77e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941967792   4 HEKLNYVEFPACDLTATKSFFTNVFNWQFTDY---GPEYTAFS-GQGLDGGFFNAPLKSLTQHgaALLVFYSNDIHATYK 79
Cdd:COG3324    2 PGTIVWVELPVDDLERAKAFYEEVFGWTFEDDagpGGDYAEFDtDGGQVGGLMPGAEEPGGPG--WLLYFAVDDLDAAVA 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 941967792  80 KVAQYGGKIVKPIFEFPG-GCRFHFTEPSGNEFAVWSEKQ 118
Cdd:COG3324   80 RVEAAGGTVLRPPTDIPPwGRFAVFRDPEGNRFGLWQPAA 119
Glyoxalase pfam00903
Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;
6-113 1.90e-13

Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;


Pssm-ID: 395724 [Multi-domain]  Cd Length: 121  Bit Score: 61.70  E-value: 1.90e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941967792    6 KLNYVEFPACDLTATKSFFTNVFNWQF---TDYGPEYTAFSGQGLDGG-----FFNA----PLKSLTQHGAALLVFYSND 73
Cdd:pfam00903   1 RIDHVALRVGDLEKSLDFYTDVLGFKLveeTDAGEEGGLRSAFFLAGGrvlelLLNEtpppAAAGFGGHHIAFIAFSVDD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 941967792   74 IHATYKKVAQYGGKIVKPIFEFPGGCR-FHFTEPSGNEFAV 113
Cdd:pfam00903  81 VDAAYDRLKAAGVEIVREPGRHGWGGRySYFRDPDGNLIEL 121
GloA COG0346
Catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family [Secondary ...
 6-109 1.05e-05

Catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440115 [Multi-domain]  Cd Length: 125  Bit Score: 41.52  E-value: 1.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941967792   6 KLNYVEFPACDLTATKSFFTNVFNWQ------FTDYGPEYTAFS-GQGLDGGFFNAPLKSLTQHGAAL--LVFYSNDIHA 76
Cdd:COG0346    2 GLHHVTLRVSDLEASLAFYTDVLGLElvkrtdFGDGGFGHAFLRlGDGTELELFEAPGAAPAPGGGGLhhLAFRVDDLDA 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 941967792  77 TYKKVAQYGGKIVKPIFEFPGGCR-FHFTEPSGN 109
Cdd:COG0346   82 AYARLRAAGVEIEGEPRDRAYGYRsAYFRDPDGN 115
VOC cd06587
vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed ...
 9-111 8.32e-04

vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.


Pssm-ID: 319898 [Multi-domain]  Cd Length: 112  Bit Score: 36.35  E-value: 8.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941967792   9 YVEFPACDLTATKSFFTNVFNWQ--FTDYGPEYTAFS-GQGLDGGFF-NAPLKSLTQHGAALLVFYSNDIHATYKKVAQY 84
Cdd:cd06587    1 HVALRVPDLDASVAFYEEVLGFEvvSRNEGGGFAFLRlGPGLRLALLeGPEPERPGGGGLFHLAFEVDDVDEVDERLREA 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 941967792  85 GGK---IVKPIFEFPGGCRFHFTEPSGNEF 111
Cdd:cd06587   81 GAEgelVAPPVDDPWGGRSFYFRDPDGNLI 110
VOC_like cd07263
uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate ...
 67-113 3.99e-03

uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping


Pssm-ID: 319924 [Multi-domain]  Cd Length: 120  Bit Score: 34.58  E-value: 3.99e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 941967792  67 LVFYSNDIHATYKKVAQYGGKIVKPIFEFPGGCRFHFTEPSGNEFAV 113
Cdd:cd07263   72 ILLATDDIDATYERLTAAGVTFVQEPTQMGGGRVANFRDPDGNLFAL 118
COG3607 COG3607
Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function ...
 6-114 8.35e-03

Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function prediction only];


Pssm-ID: 442825  Cd Length: 126  Bit Score: 33.65  E-value: 8.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941967792   6 KLNYVEFPACDLTATKSFFTNV---FNWQFTDygPEYTAF-SGQGLDGGFF---------NAPLKSLTQHGAALLVFysN 72
Cdd:COG3607    3 RIIFVNLPVADLERSRAFYEALgftFNPQFSD--EGAACFvLGEGIVLMLLprekfatftGKPIADATGFTEVLLAL--N 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 941967792  73 -----DIHATYKKVAQYGGKIVKPIFEFPGGCRFHFTEPSGNefaVW 114
Cdd:COG3607   79 vesreEVDALVAKALAAGGTVLKPPQDVGGMYSGYFADPDGH---LW 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH