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Conserved domains on  [gi|942017053|ref|WP_055267537|]
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MULTISPECIES: MFS transporter [Bacillota]

Protein Classification

MFS transporter( domain architecture ID 11454559)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020|GO:0015293|GO:0008643
PubMed:  26098515|23403214|26758938|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
5-450 2.84e-80

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


:

Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 255.21  E-value: 2.84e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053   5 SKKQKVSIVEKMGLFMVCAGNIPLMGLLSGFFMIYYTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKFPvTKMGKF 84
Cdd:COG2211    2 AAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTR-TRWGRR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  85 RPMIILGTIICVINYILLWFGAVWIPVGKYVIVYVTYLLLGWTFDIMDISKNSLLPVMSADDKERNSLSLFNALGTMIGS 164
Cdd:COG2211   81 RPWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 165 AVLAVAAPILVA---EGTLQNYYVLIFGSMAMVLVLSIAGALCVKERVAFEGKKeeSYTFRELLQFLRYKPVWALFLVAL 241
Cdd:COG2211  161 LLASVLPPPLVAafgGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEK--VSLKESLKALLKNRPFLLLLLAYL 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 242 VVGVGSNIAGGAGAYFYTYILGD-MTLMSGVSLVSMITALVGIFLGPILANRFGKKQIFVMAIVVSIL-FSALRLIDVRS 319
Cdd:COG2211  239 LFFLALALVAALLLYYFKYVLGLsAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALgLLLLFFLGPGN 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 320 MLLIYISTVAGGVAGGCIAPLTTSIQADNTTYVQYKTGKRAEAAIASLTSFITKVAQGLGGAIPGYVLAATGFVTGsVAQ 399
Cdd:COG2211  319 LWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAG-AAQ 397

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 942017053 400 PESINTGIILCVLILPTILTAAGAILFGTqYTLDKKAVEEMHTAIAARSNK 450
Cdd:COG2211  398 SPSALTGIRLLFFLLPAVLLLLAALLLLF-YPLTRERHAEIRAELAARRAA 447
 
Name Accession Description Interval E-value
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
5-450 2.84e-80

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 255.21  E-value: 2.84e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053   5 SKKQKVSIVEKMGLFMVCAGNIPLMGLLSGFFMIYYTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKFPvTKMGKF 84
Cdd:COG2211    2 AAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTR-TRWGRR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  85 RPMIILGTIICVINYILLWFGAVWIPVGKYVIVYVTYLLLGWTFDIMDISKNSLLPVMSADDKERNSLSLFNALGTMIGS 164
Cdd:COG2211   81 RPWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 165 AVLAVAAPILVA---EGTLQNYYVLIFGSMAMVLVLSIAGALCVKERVAFEGKKeeSYTFRELLQFLRYKPVWALFLVAL 241
Cdd:COG2211  161 LLASVLPPPLVAafgGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEK--VSLKESLKALLKNRPFLLLLLAYL 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 242 VVGVGSNIAGGAGAYFYTYILGD-MTLMSGVSLVSMITALVGIFLGPILANRFGKKQIFVMAIVVSIL-FSALRLIDVRS 319
Cdd:COG2211  239 LFFLALALVAALLLYYFKYVLGLsAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALgLLLLFFLGPGN 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 320 MLLIYISTVAGGVAGGCIAPLTTSIQADNTTYVQYKTGKRAEAAIASLTSFITKVAQGLGGAIPGYVLAATGFVTGsVAQ 399
Cdd:COG2211  319 LWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAG-AAQ 397

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 942017053 400 PESINTGIILCVLILPTILTAAGAILFGTqYTLDKKAVEEMHTAIAARSNK 450
Cdd:COG2211  398 SPSALTGIRLLFFLLPAVLLLLAALLLLF-YPLTRERHAEIRAELAARRAA 447
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 15-433 3.28e-72

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 233.65  E-value: 3.28e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  15 KMGLFMVCAGNIPLMGLLSGFFMIYYTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKFPvTKMGKFRPMIILGTII 94
Cdd:cd17332    1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTR-SRWGRFRPWLLWGAIP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  95 CVINYILLWFGAVWIPVGKYVIVYVTYLLLGWTFDIMDISKNSLLPVMSADDKERNSLSLFNALGTMIGSAVLAVAAPIL 174
Cdd:cd17332   80 LALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 175 VAEGTLQNYYVLIFGSMAMVLVLSIAGALC----VKERV-AFEGKKEESYTFRELLQFLRYKPVWALFLVALVVGVGSNI 249
Cdd:cd17332  160 VAYFGGGNASRGYFLTALIIGIIGIILLLIcffgTRERVvPPEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 250 AGGAGAYFYTYILGDMTLMSGVSLVSMITALVGIFLGPILANRFGKKQIFVMAIVVSILFSALRLIDV-RSMLLIYISTV 328
Cdd:cd17332  240 VNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPpGNLVLILVLAV 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 329 AGGVAGGCIAPLTTSIQADNTTYVQYKTGKRAEAAIASLTSFITKVAQGLGGAIPGYVLAATGFVTGSVAQPESINTGII 408
Cdd:cd17332  320 LAGIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVANAAAQSASALNGIR 399

                        410       420
                 ....*....|....*....|....*
gi 942017053 409 LCVLILPTILTAAGAILFGTQYTLD 433
Cdd:cd17332  400 LLIAVLPAVLLLLALILMSFYPLDK 424
gph TIGR00792
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ...
 30-440 3.54e-68

sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273270  Cd Length: 437  Bit Score: 223.67  E-value: 3.54e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053   30 GLLSGFFMIYYTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKFPvTKMGKFRPMIILGTIICVINYILLWFGAVWI 109
Cdd:TIGR00792  16 AIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRTR-TRWGKFRPWLLIGAIPFSIVLVLLFTTPDFS 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  110 PVGKYVIVYVTYLLLGWTFDIMDISKNSLLPVMSADDKERNSLSLFNALGTMIGSAVLAVAAPILVAEGTLQNYYVLIFG 189
Cdd:TIGR00792  95 GTGKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRRFGATLGGLLVAVIVLPLVSYFGGGDDKFGWFM 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  190 SMAMV----LVLSIAGALCVKERV-AFEGKKEESYTFRELLQ-FLRYKPVWALFLVALVVGVGSNIAGGAGAYFYTYILG 263
Cdd:TIGR00792 175 FALVLaligVVSLIICFFGTKERYsEIPKNIEKKLSLKQIFKaLFKNDQLLILCLAYLFYNLAFNIKNGVQVYYFTYVLG 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  264 DMTLMSGVSLVSMITALVGIFLGPILANRFGKKQIFVMAIVVSILFSALRLIDVRSMLLIYISTVAGGVAGGCIAPLTTS 343
Cdd:TIGR00792 255 DPELFSYMGSIAIVAGLIGVLLFPRLVKKFGRKILFAGGILLMVLGYLIFFFAGSNLPLILVLIILAGFGQNIVTGLVWA 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  344 IQADNTTYVQYKTGKRAEAAIASLTSFITKVAQGLGGAIPGYVLAATGFVTGSVAQPESINtGIILCVLILPTILTAAGA 423
Cdd:TIGR00792 335 LVADTVDYGEWKTGIRAEGLVYSVRTFVRKLGQALAGFFVGLILGIIGYVANAAQSPITLN-GIKILMFAVPALFLLLAA 413

                         410
                  ....*....|....*..
gi 942017053  424 ILFGTQYTLDKKAVEEM 440
Cdd:TIGR00792 414 IIIGRFYKLTEKKHAEI 430
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 23-426 3.74e-64

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 212.94  E-value: 3.74e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053   23 AGNIPLMGLLSGFFMIYYTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKfPVTKMGKFRPMIILGTIICVINYILL 102
Cdd:pfam13347   7 LAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDR-TRTRWGRRRPWLLLSAIILAVSFILL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  103 WFGAVWIPVGKYVIVYVTYLLLGWTFDIMDISKNSLLPVMSADDKERNSLSLFNALGTMIGSAVLAVAAPILVA-EGTLQ 181
Cdd:pfam13347  86 FTPPELGRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVLiLGGTG 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  182 NYYVLIFGSMAMVLVLSIAG----ALCVKERVAFEGKKEE-----SYTFRELLQFLRYKPVWALFLVALVVGVGSNIAGG 252
Cdd:pfam13347 166 LERKGYRIFALIGAVLMLLGviitAAGTKERVSMRSKEDTgqkeaGSLLDMLKEVFRNRAFLILLASFLLAALAMGVLNG 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  253 AGAYFYTYILGDMTLMSGVSLVSMITALVGIFLGPILANRFGKKQIFVMAIVVSILFSALRLIDV-RSMLLIYISTVAGG 331
Cdd:pfam13347 246 LLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGpNNTLLFLVLYIIIG 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  332 VAGGCIAPLTTSIQADNTTYVQYKTGKRAEAAIASLTSFITKVAQGLGGAIPGYVLAATGFVTGSVAQPESINTGIILCV 411
Cdd:pfam13347 326 FGYGSSFFLPWSMLADVVDYGELRTGKRREGTFFAMWSFISKLATGVGLGVSGLLLSAFGYNAGDSVQSPQAVTAIRLLY 405

                         410
                  ....*....|....*
gi 942017053  412 LILPTILTAAGAILF 426
Cdd:pfam13347 406 AVLPAVLFLVALLLL 420
PRK10429 PRK10429
melibiose:sodium transporter MelB;
30-432 2.17e-43

melibiose:sodium transporter MelB;


Pssm-ID: 182453  Cd Length: 473  Bit Score: 158.72  E-value: 2.17e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  30 GLLSGFFMIYYTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKfPVTKMGKFRPMIILGTIICVINYILLwFGAVWI 109
Cdd:PRK10429  23 GIVYMYLMYYYTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVNN-TRSRWGKFKPWILIGTLANSVVLFLL-FSAHLF 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 110 P-VGKYVIVYVTYLLLGWTFDIMDISKNSLLPVMSADDKERNSLS----LFNALGTMIgsaVLAVAAPILVAEGT----- 179
Cdd:PRK10429 101 EgTAQYVFVCVTYILWGMTYTIMDIPFWSLVPTLTLDKREREQLVpyprFFASLAGFV---TAGFTLPFVNYVGGgdrgf 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 180 -LQNYYVLIfgsmAMVLVLSIAGALC-VKERVAF---EGKKEESYTFRELLQFL-RYKPVWALFLVALVVGVGSNIAGGA 253
Cdd:PRK10429 178 gFQMFTLVL----IAFFIVSTIITLRnVHEVYSSdnqVSAEGSHLTLKDIVALIyKNDQLSCLLGMALAYNIASNIINGF 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 254 GAYFYTYILGDMTLMSGVSLVSMITALVGIFLGPILANRFGKKQIFVMAIVVSILFSALRLI----DVRSMLLIYISTVA 329
Cdd:PRK10429 254 AIYYFTYVIGDADLFPYYLSYAGAANLVTLILFPRLVKSLSRRILWAGASIFPVLSCGVLLLmglaAPHNALLIVIAGIL 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 330 GGVAGGCIAPLTTSIQADNTTYVQYKTGKRAEAAIASLTSFITKVAQGLGGAIPGYVLAATGFVTGSVAQPESINtGIIL 409
Cdd:PRK10429 334 LNIGTALFWVLQVIMVADTVDYGEYKLGIRCESIAYSVQTMVVKGGSAFAAFFIGVVLGLIGYVPNVEQSAQTLL-GMQF 412

                        410       420
                 ....*....|....*....|...
gi 942017053 410 CVLILPTILTAAGAILFGTQYTL 432
Cdd:PRK10429 413 IMIGLPTLFFMITLVLYFRYYRL 435
 
Name Accession Description Interval E-value
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
5-450 2.84e-80

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 255.21  E-value: 2.84e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053   5 SKKQKVSIVEKMGLFMVCAGNIPLMGLLSGFFMIYYTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKFPvTKMGKF 84
Cdd:COG2211    2 AAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTR-TRWGRR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  85 RPMIILGTIICVINYILLWFGAVWIPVGKYVIVYVTYLLLGWTFDIMDISKNSLLPVMSADDKERNSLSLFNALGTMIGS 164
Cdd:COG2211   81 RPWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 165 AVLAVAAPILVA---EGTLQNYYVLIFGSMAMVLVLSIAGALCVKERVAFEGKKeeSYTFRELLQFLRYKPVWALFLVAL 241
Cdd:COG2211  161 LLASVLPPPLVAafgGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEK--VSLKESLKALLKNRPFLLLLLAYL 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 242 VVGVGSNIAGGAGAYFYTYILGD-MTLMSGVSLVSMITALVGIFLGPILANRFGKKQIFVMAIVVSIL-FSALRLIDVRS 319
Cdd:COG2211  239 LFFLALALVAALLLYYFKYVLGLsAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALgLLLLFFLGPGN 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 320 MLLIYISTVAGGVAGGCIAPLTTSIQADNTTYVQYKTGKRAEAAIASLTSFITKVAQGLGGAIPGYVLAATGFVTGsVAQ 399
Cdd:COG2211  319 LWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAG-AAQ 397

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 942017053 400 PESINTGIILCVLILPTILTAAGAILFGTqYTLDKKAVEEMHTAIAARSNK 450
Cdd:COG2211  398 SPSALTGIRLLFFLLPAVLLLLAALLLLF-YPLTRERHAEIRAELAARRAA 447
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 15-433 3.28e-72

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 233.65  E-value: 3.28e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  15 KMGLFMVCAGNIPLMGLLSGFFMIYYTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKFPvTKMGKFRPMIILGTII 94
Cdd:cd17332    1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTR-SRWGRFRPWLLWGAIP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  95 CVINYILLWFGAVWIPVGKYVIVYVTYLLLGWTFDIMDISKNSLLPVMSADDKERNSLSLFNALGTMIGSAVLAVAAPIL 174
Cdd:cd17332   80 LALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 175 VAEGTLQNYYVLIFGSMAMVLVLSIAGALC----VKERV-AFEGKKEESYTFRELLQFLRYKPVWALFLVALVVGVGSNI 249
Cdd:cd17332  160 VAYFGGGNASRGYFLTALIIGIIGIILLLIcffgTRERVvPPEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 250 AGGAGAYFYTYILGDMTLMSGVSLVSMITALVGIFLGPILANRFGKKQIFVMAIVVSILFSALRLIDV-RSMLLIYISTV 328
Cdd:cd17332  240 VNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPpGNLVLILVLAV 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 329 AGGVAGGCIAPLTTSIQADNTTYVQYKTGKRAEAAIASLTSFITKVAQGLGGAIPGYVLAATGFVTGSVAQPESINTGII 408
Cdd:cd17332  320 LAGIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVANAAAQSASALNGIR 399

                        410       420
                 ....*....|....*....|....*
gi 942017053 409 LCVLILPTILTAAGAILFGTQYTLD 433
Cdd:cd17332  400 LLIAVLPAVLLLLALILMSFYPLDK 424
gph TIGR00792
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ...
 30-440 3.54e-68

sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273270  Cd Length: 437  Bit Score: 223.67  E-value: 3.54e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053   30 GLLSGFFMIYYTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKFPvTKMGKFRPMIILGTIICVINYILLWFGAVWI 109
Cdd:TIGR00792  16 AIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRTR-TRWGKFRPWLLIGAIPFSIVLVLLFTTPDFS 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  110 PVGKYVIVYVTYLLLGWTFDIMDISKNSLLPVMSADDKERNSLSLFNALGTMIGSAVLAVAAPILVAEGTLQNYYVLIFG 189
Cdd:TIGR00792  95 GTGKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRRFGATLGGLLVAVIVLPLVSYFGGGDDKFGWFM 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  190 SMAMV----LVLSIAGALCVKERV-AFEGKKEESYTFRELLQ-FLRYKPVWALFLVALVVGVGSNIAGGAGAYFYTYILG 263
Cdd:TIGR00792 175 FALVLaligVVSLIICFFGTKERYsEIPKNIEKKLSLKQIFKaLFKNDQLLILCLAYLFYNLAFNIKNGVQVYYFTYVLG 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  264 DMTLMSGVSLVSMITALVGIFLGPILANRFGKKQIFVMAIVVSILFSALRLIDVRSMLLIYISTVAGGVAGGCIAPLTTS 343
Cdd:TIGR00792 255 DPELFSYMGSIAIVAGLIGVLLFPRLVKKFGRKILFAGGILLMVLGYLIFFFAGSNLPLILVLIILAGFGQNIVTGLVWA 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  344 IQADNTTYVQYKTGKRAEAAIASLTSFITKVAQGLGGAIPGYVLAATGFVTGSVAQPESINtGIILCVLILPTILTAAGA 423
Cdd:TIGR00792 335 LVADTVDYGEWKTGIRAEGLVYSVRTFVRKLGQALAGFFVGLILGIIGYVANAAQSPITLN-GIKILMFAVPALFLLLAA 413

                         410
                  ....*....|....*..
gi 942017053  424 ILFGTQYTLDKKAVEEM 440
Cdd:TIGR00792 414 IIIGRFYKLTEKKHAEI 430
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 23-426 3.74e-64

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 212.94  E-value: 3.74e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053   23 AGNIPLMGLLSGFFMIYYTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKfPVTKMGKFRPMIILGTIICVINYILL 102
Cdd:pfam13347   7 LAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDR-TRTRWGRRRPWLLLSAIILAVSFILL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  103 WFGAVWIPVGKYVIVYVTYLLLGWTFDIMDISKNSLLPVMSADDKERNSLSLFNALGTMIGSAVLAVAAPILVA-EGTLQ 181
Cdd:pfam13347  86 FTPPELGRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVLiLGGTG 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  182 NYYVLIFGSMAMVLVLSIAG----ALCVKERVAFEGKKEE-----SYTFRELLQFLRYKPVWALFLVALVVGVGSNIAGG 252
Cdd:pfam13347 166 LERKGYRIFALIGAVLMLLGviitAAGTKERVSMRSKEDTgqkeaGSLLDMLKEVFRNRAFLILLASFLLAALAMGVLNG 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  253 AGAYFYTYILGDMTLMSGVSLVSMITALVGIFLGPILANRFGKKQIFVMAIVVSILFSALRLIDV-RSMLLIYISTVAGG 331
Cdd:pfam13347 246 LLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGpNNTLLFLVLYIIIG 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  332 VAGGCIAPLTTSIQADNTTYVQYKTGKRAEAAIASLTSFITKVAQGLGGAIPGYVLAATGFVTGSVAQPESINTGIILCV 411
Cdd:pfam13347 326 FGYGSSFFLPWSMLADVVDYGELRTGKRREGTFFAMWSFISKLATGVGLGVSGLLLSAFGYNAGDSVQSPQAVTAIRLLY 405

                         410
                  ....*....|....*
gi 942017053  412 LILPTILTAAGAILF 426
Cdd:pfam13347 406 AVLPAVLFLVALLLL 420
PRK10429 PRK10429
melibiose:sodium transporter MelB;
30-432 2.17e-43

melibiose:sodium transporter MelB;


Pssm-ID: 182453  Cd Length: 473  Bit Score: 158.72  E-value: 2.17e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  30 GLLSGFFMIYYTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKfPVTKMGKFRPMIILGTIICVINYILLwFGAVWI 109
Cdd:PRK10429  23 GIVYMYLMYYYTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVNN-TRSRWGKFKPWILIGTLANSVVLFLL-FSAHLF 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 110 P-VGKYVIVYVTYLLLGWTFDIMDISKNSLLPVMSADDKERNSLS----LFNALGTMIgsaVLAVAAPILVAEGT----- 179
Cdd:PRK10429 101 EgTAQYVFVCVTYILWGMTYTIMDIPFWSLVPTLTLDKREREQLVpyprFFASLAGFV---TAGFTLPFVNYVGGgdrgf 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 180 -LQNYYVLIfgsmAMVLVLSIAGALC-VKERVAF---EGKKEESYTFRELLQFL-RYKPVWALFLVALVVGVGSNIAGGA 253
Cdd:PRK10429 178 gFQMFTLVL----IAFFIVSTIITLRnVHEVYSSdnqVSAEGSHLTLKDIVALIyKNDQLSCLLGMALAYNIASNIINGF 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 254 GAYFYTYILGDMTLMSGVSLVSMITALVGIFLGPILANRFGKKQIFVMAIVVSILFSALRLI----DVRSMLLIYISTVA 329
Cdd:PRK10429 254 AIYYFTYVIGDADLFPYYLSYAGAANLVTLILFPRLVKSLSRRILWAGASIFPVLSCGVLLLmglaAPHNALLIVIAGIL 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 330 GGVAGGCIAPLTTSIQADNTTYVQYKTGKRAEAAIASLTSFITKVAQGLGGAIPGYVLAATGFVTGSVAQPESINtGIIL 409
Cdd:PRK10429 334 LNIGTALFWVLQVIMVADTVDYGEYKLGIRCESIAYSVQTMVVKGGSAFAAFFIGVVLGLIGYVPNVEQSAQTLL-GMQF 412

                        410       420
                 ....*....|....*....|...
gi 942017053 410 CVLILPTILTAAGAILFGTQYTL 432
Cdd:PRK10429 413 IMIGLPTLFFMITLVLYFRYYRL 435
PRK09848 PRK09848
glucuronide transporter; Provisional
 29-447 4.45e-42

glucuronide transporter; Provisional


Pssm-ID: 182109 [Multi-domain]  Cd Length: 448  Bit Score: 154.56  E-value: 4.45e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  29 MGLLsgFFMIYYTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKFPvTKMGKFRPMIILGTIICVINYILL-WFGAV 107
Cdd:PRK09848  26 MGAL--FLLSYYTDVAGVGAAAAGTMLLLVRVFDAFADVFAGRVVDSVN-TRWGKFRPFLLFGTAPLMIFSVLVfWVPTD 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 108 WIPVGKYVIVYVTYLLLGWTFDIMDISKNSLLPVMSADDKERNSLS---------LFNALGTMIGSAVLAVAAPILVAEG 178
Cdd:PRK09848 103 WSHSSKVVYAYLTYMGLGLCYSLVNIPYGSLATAMTQQPQSRARLGaargiaaslTFVCLAFLIGPSIKNSSPEEMVSVY 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 179 TlqnYYVLIFGSMAMVLVLsiagaLCVKERVAFEGKKEESYTFRELLQFL-RYKPVWALFLVALVVGVGSNIAGGAGAYF 257
Cdd:PRK09848 183 H---FWTIVLAIAGMVLYF-----ICFKSTRENVVRIVAQPSLKISLQTLkRNRPLFMLCIGALCVLISTFAVSASSLFY 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 258 YTYILGDMTLMSgvsLVSMITALVGIFLG----PILANRFGKKQIFVMAIVVSIL-FSALRLIDVRSMLLIYISTVAGGV 332
Cdd:PRK09848 255 VRYVLNDTGLFT---VLVLVQNLVGTVASaplvPGMVARIGKKNTFLIGALLGTCgYLLFFWVSVWSLPVALVALAIASI 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 333 AGGCIAPLTTSIQADNTTYVQYKTGKRAEAAIASLTSFITKVAQGLGGAIPGYVLAATGFVTGSVAQPESInTGIILCVL 412
Cdd:PRK09848 332 GQGVTMTVMWALEADTVEYGEYLTGVRIEGLTYSLFSFTRKCGQAIGGSIPAFILGLSGYIANQVQTPEVI-MGIRTSIA 410

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 942017053 413 ILPTILTaAGAILFGTQYTLDKKAVEEMHTAIAAR 447
Cdd:PRK09848 411 LVPCGFM-LLAFVIIWFYPLTDKKFKEIVVEIDNR 444
PRK09669 PRK09669
putative symporter YagG; Provisional
 35-440 5.56e-37

putative symporter YagG; Provisional


Pssm-ID: 236610  Cd Length: 444  Bit Score: 140.63  E-value: 5.56e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  35 FFMIY-YTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKfPVTKMGKFRPMIILGTI----ICVINYILLWFGavwi 109
Cdd:PRK09669  30 LFLAYfYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDR-TRTRHGQFRPYLLWFAIpfgvVCLLTFYTPDFG---- 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 110 PVGKYVIVYVTYLLLGWTFDIMDISKNSLLPVMSADDKERNSLSLFNALGTMIGSAVLAVAAPILVA---EGTLQNYYvl 186
Cdd:PRK09669 105 ATGKIIYACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIGGLIVSVIALPLVDilgKGDEQKGY-- 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 187 iFGSMAMVLVLSIAGALC----VKERVAFEGKKEESyTFRELLQFLRYKPVWALFLVALVVGVGSNIAGGAGAYFYTYIL 262
Cdd:PRK09669 183 -FYAMMVMGLLGVVLFFCcffmTKERYTPEVDNSSS-VWKDLKLLLGNSQWRIMFIFNVVLLTAVVTRGGATLYYVNYVL 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 263 GDMTLMSGVSLVSMITALVGIFLGPILANRFGKKQIFVMAIVVSILFSALRLIDVRSML-LIYISTVAGGVAGGCIAPLT 341
Cdd:PRK09669 261 LRPDLATLFLVTGMIAGLFGALLSERLLGKFDRVRAFKWTIVAFVILSALIFFIPPSNVwLIFALNILFNFIQNLTTPLQ 340

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 342 TSIQADNTTYVQYKTGKRAEAAIASLTSFITKVAQGLGGAIPGYVLAATGFVTGSVAQPESINTGIILCVLILPTILTAA 421
Cdd:PRK09669 341 WSMFSDVVDYEEKRSGRRLDGLVFSTNLFAIKLGLAIGGAVVGWILAWVDYVGGAAVQSASVLTTINLLFTVIPGVLFAG 420

                        410
                 ....*....|....*....
gi 942017053 422 GAILFgTQYTLDKKAVEEM 440
Cdd:PRK09669 421 MAIIL-NFYKLNDARVEAI 438
MFS_NLS1_MFSD2A cd17451
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ...
 34-426 1.16e-27

Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341009  Cd Length: 419  Bit Score: 114.14  E-value: 1.16e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  34 GFFM-IYYTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKFPVTKMGKFRPMIILGTIICVINYILLWFgAVWIPVG 112
Cdd:cd17451   19 GFFLqIYLLDVAQLDPFYASIILFVGRAWDAITDPTVGFFVSKSPWTRFGRLMPWIIFSTPFAVLSYFLIWF-VPDFSQG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 113 KYVIVYVTYLLLGWTFDIMDISKNSLLPVMSADDKERNSLSLF----NALGTMIGSAV---LAVAAPILVAEGTLQNYYV 185
Cdd:cd17451   98 KVMWYLLFYCLFQTLQTCFHVPYSALTMFISTEQKERDSATAYrmtvEVLGTVLGTAIqgqIVGMAAYMIAAGVICAIYV 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 186 LIfgsmAMVLVLSIAgalcvKERVAFEGKKEESYTFRELLQF-LRYKPVWALFLVALVVGVGSNIAGGAGAYFYTYILGD 264
Cdd:cd17451  178 LC----AIILFLGVR-----EQREPCELKSQKPVSFFKGLKLvMSHGPYIKLITGFLFTSLAFMLLEGNFALFCTYTLGF 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 265 MTLMSGVSLVSMITALVGIFLGPILANRFGKKQIFVMAIVVSILFSALRLIDVRSMLLIYISTVAGGVAGGCIAPLTTSI 344
Cdd:cd17451  249 RNDFQNILLVIMLSATLTIPFWQWFLTRFGKKTAVYIGISSAVPFLILVVLVESNLIVTYVVSVAAGVSVAAAFLLPWSM 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 345 QAD--NTTYVQYKTGKRAEAAIASLTSFITKVAQGLGGAIPGYVLAATGFVTGSVAQPESINTGIILCVLILPTILTAAG 422
Cdd:cd17451  329 LPDvvDDFKLKNPDSQGHEAIFYSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPEEVNLTLKMLVSAAPVVLILLG 408


                 ....
gi 942017053 423 AILF 426
Cdd:cd17451  409 LLLF 412
PRK11462 PRK11462
putative transporter; Provisional
 6-450 1.79e-24

putative transporter; Provisional


Pssm-ID: 183145  Cd Length: 460  Bit Score: 105.40  E-value: 1.79e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053   6 KKQKVSIVEKMGLFMVCAGNIPLMGLLSGFFMIYYTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKfPVTKMGKFR 85
Cdd:PRK11462   2 KSEVLSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADR-TRSRWGKFR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  86 PMIILGTIICVINYILLWFGAVWIPVGKYVIVYVTYLLLGWTFDIMDISKNSLLPVMSADDKERNSLSLFN-ALGTMIGS 164
Cdd:PRK11462  81 PWVLFGALPFGIVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRfVLATAGGM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 165 AVLAVAAPILVAEGTLQNYYVLIFGSMAMVLVLSIAGALC---VKERVAfegKKEESYTFRELLQFLRYKPVWALFLVAL 241
Cdd:PRK11462 161 LSTVLMMPLVNLIGGDNKPLGFQGGIAVLSVVAFMMLAFCfftTKERVE---APPTTTSMREDLRDIWQNDQWRIVGLLT 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 242 VVGV-GSNIAGGAGAYFYTYILGDMTLMSGVSLVSMITALVGIFLGPILANRFGKKQIFVMA-IVVSILFSALRLIDVRS 319
Cdd:PRK11462 238 IFNIlAVCVRGGAMMYYVTWILGTPEVFVAFLTTYCVGNLIGSALAKPLTDWKCKVTIFWWTnALLAVISLAMFFVPMQA 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 320 MLLIYISTVAGGVAGGCIAPLTTSIQADNTTYVQYKTGKRAEAAIASLTSFITKVAQGLGGAIPGYVLAATGFVTGSVAQ 399
Cdd:PRK11462 318 SITMFVFIFVIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKAQ 397

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 942017053 400 PESINTGIILCVLILPTILTAAGAILFGTQYTLD----KKAVEEMhtAIAARSNK 450
Cdd:PRK11462 398 NSATISIIIALFTIVPAICYLLSAIIAKRYYSLTthnlKTVMEQL--AQGKRRCQ 450
MFS_MFSD2B cd17452
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily ...
 24-426 1.37e-18

Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily domain-containing protein 2B (MFSD2B) is closely related to MFSD2A, and their conserved genomic structure suggests that they are derived from the duplication of an ancestral gene. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer identified MFSD2B as a potential risk or protect factor in the prognosis of lung adenocarcinoma. MFSD2B belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341010  Cd Length: 416  Bit Score: 87.57  E-value: 1.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  24 GNIP--LMGLLSGFFM-IYYTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKFPVTKMGKFRPMIILGTIICVINYI 100
Cdd:cd17452    7 GGAPnqVAGSATAFFLqIYLLDIAQITPFQASLVLFVGKAWGAATDPVVGFFISKSKWTKIGRLMPWMLGCTPFIVVSYF 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 101 LLWFGAVWIpVGKYVIVYVTYLLLGWTFDIMDISKNSLLPVMSADDKERNSLSLF----NALGTMIGSAV--LAVAAPIL 174
Cdd:cd17452   87 FLWFVPPFT-TGRFLWYLTFYCLFQALATCFHVPYSALTMFLSTDQRERDSATAYrmtvEVLGTLVGAAVqgQIVASAYM 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 175 VAEGTLQNYYvlifgsmamvLVLSIAGALCVKER---VAFEGKKEESYtFRELLQFLRYKPVWALFLVALVVGVGSNIAG 251
Cdd:cd17452  166 IAAGVIGGLY----------LLCISVLFLGVKERddpYAPKSGKAIPF-FKGLSLTMRHGPYLKLTASFLFISAAVQLEQ 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 252 GAGAYFYTYILGDMTLMSGVSLVSMITALVGIFLGPILANRFGKKQIFvMAIVVSILFSALrLIDVRSMLLIYISTVAGG 331
Cdd:cd17452  235 SNFVLFCTHAVDLHDHFQNLVLTILVSAVVSIPFWQWFLQRFGKKAAA-CGISWMIPFAIM-LVTIPNLIVAYVVAFVSG 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 332 VAGGCIAPLTTSIQAD--NTTYVQYKTGKRAEAAIASLTSFITKVAQGLGGAIPGYVLAATGFVTGSVAQPESINTGIIL 409
Cdd:cd17452  313 LSIAASLLLPWSMLPDvvDDFRLQNPHGKGLETIFYSSYVFFTKLSAGIALGISTLSLEFAGYETGACKQPESVVLTLKL 392

                        410
                 ....*....|....*..
gi 942017053 410 CVLILPTILTAAGAILF 426
Cdd:cd17452  393 LIGAAPTCMILIGLCIL 409
MFS_MFSD2 cd17392
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator ...
 34-426 1.35e-15

Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator superfamily domain-containing protein 2 (MFSD2) subfamily is composed of two vertebrate members, MFSD2A amd MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD2 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340950  Cd Length: 446  Bit Score: 78.67  E-value: 1.35e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  34 GFFM-IYYTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKFPVTKMGKFRPMIILGTIICVINYILLWFgavwIPVG 112
Cdd:cd17392   19 GFFLqIFLLDVAQMGAFSVSLILFVGRVWDAVTDPLVGYFISRSQRTGIGRLMPWIVFSTPLIILAYFFLWF----LPPF 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 113 KYVIVYvTYLLLGWTFDIM----DISKNSLLPVMSADDKERNSLSLF----NALGTMIGSAVL--------------AVA 170
Cdd:cd17392   95 TSLSGL-WYLTFYCLFETFmtcfHVPYSALTMFLGGCQRERDSATAYrmtvEVFGTLMGATIQgqivgvahrprrqdCTA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 171 APILVAEGT--LQNYYVLIFGSMAMVLVLSIAGA----LCVKERVA-FEGKKEESYTF-RELLQFLRYKPVWALFLVALV 242
Cdd:cd17392  174 TPGTSDHPVtvLPNTRRAYLIAALVVVVLYFVCCsilfLGVKEQPDpLSPASGPGLSYlAGLKLVTGHPPYLKLVIGFLF 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 243 VGVGSNIAGGAGAYFYTYILGDMTLMSGVSLVSMITALVGIFLGPILANRFGKKQIFVMAIVVSILFSALRLIDVRSMLL 322
Cdd:cd17392  254 SSLAFQMEQGNFVLFCTHAAGLGDHFQHLVLAILVSATLSIPLWQWVLQRRGKKTTSFIGISAMVPFLILLALVPSNLPV 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 323 IYISTVAGGVAGGCIAPLTTSIQAD--NTTYVQYKTGKRAEAAIASLTSFITKVAQGLGGAIPGYVLAATGFVTGSVAQP 400
Cdd:cd17392  334 AYVVAVVSGVSLAALFLLPWSMLPDvvDDFQLKNPHCPGLEPIFYSCYVFFTKLGGGLSLGISTLSLHFSGYKAGACKQP 413

                        410       420
                 ....*....|....*....|....*.
gi 942017053 401 ESINTGIILCVLILPTILTAAGAILF 426
Cdd:cd17392  414 EEVVVTLKVLIAPVPICLILAGLVLF 439
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 18-395 3.05e-11

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 64.76  E-value: 3.05e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  18 LFMVCAGNIPLMGLLSGFFMIYYTnVVGLEPAALATLFLISKVVDGISDPIMGYFLDKFPvtkmgkFRPMIILGTIICVI 97
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQ-SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFG------RRPVLLLGLLLFAL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  98 NYILLWFgavwipVGKYVIVYVTYLLLGWTFDIMDISKNSLLpVMSADDKERNSLSLFNALGTMIGSAVLAVAAPILVAE 177
Cdd:cd06174   74 GALLFAF------APSFWLLLLGRFLLGLGSGLIDPAVLALI-ADLFPERERGRALGLLQAFGSVGGILGPLLGGILASS 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 178 GTLQNYYVLIFgSMAMVLVLSIAGALCVKERVAFEGKKEESYTFRELLQFL----RYKPVWALFLVA-LVVGVGSNIAGG 252
Cdd:cd06174  147 LGFGWRAVFLI-AAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLkrvlKNPGLWLLLLAIfLVNLAYYSFSTL 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 253 AGAYFYTYILGDMTLMSGVSLVSMITALVGIFLGPILANR-FGKKQIFVMAIVVSILFSALrLIDVRSMLLIYISTVAGG 331
Cdd:cd06174  226 LPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLAL-LLLAPSLLLLLLLLLLLG 304

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 942017053 332 VAGGCIAPLTTSiqadnttYVQYKTGKRAEAAIASLTSFITKVAQGLGGAIPGYVLAATGFVTG 395
Cdd:cd06174  305 FGLGGLLPLSFA-------LIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTG 361
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
34-414 1.05e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 56.81  E-value: 1.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  34 GFFMIYYTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKFPVtkmgkfRPMIILGTIICVINYILLWFgavwipVGK 113
Cdd:COG2223   25 SVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGP------RRVLLIGLLLLGIGLLLLAL------AVS 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 114 YVIVYVTYLLLGWTFDIMDISKNSLLPVMSADDKERNSLSLFNALGtMIGSAVLAVAAPILVAEGTLQNYYVLIfgsMAM 193
Cdd:COG2223   93 YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGG-NLGAAVAAFLAPLLIAAFGWRNAFLIL---GIL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 194 VLVLSIAGALCVKERVAFEGKKEESyTFRELLQFLRYKPVWALFLvALVVGVGSNIAGGAGAYFYTYILGDMTLMSGVSL 273
Cdd:COG2223  169 LLVVAVLAWLFLRDPPAGAAAAAKA-SLRDQLEALRDPRFWLLSL-LYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLL 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 274 VSM--ITALVGIFLGPILANRFGKKQIFVMAIVVSILFSALRLIDVRSMLLIYISTVAGGVAGGCIAPLTTSIQADNtty 351
Cdd:COG2223  247 AALfaLLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDI--- 323

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 942017053 352 vqykTGKRAEAAIASLTSFItkvaQGLGGAIPGYVLAATGFVTGSVAQPESINTGIILCVLIL 414
Cdd:COG2223  324 ----FPTKNAGAVYGLVGAA----GGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVL 378
MFS_1 pfam07690
Major Facilitator Superfamily;
29-345 1.72e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 49.72  E-value: 1.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053   29 MGLLSGFFMIYYTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKFPVtkmgkfRPMIILGTIICVINYILLWFGAVW 108
Cdd:pfam07690  12 RSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGR------RRVLLIGLLLFALGLLLLLFASSL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  109 ipvgkyVIVYVTYLLLGWTFDIMDISKNSLLpVMSADDKERNSLSLFNALGTMIGSAVLAVAAPILVAEGTLQNYYvLIF 188
Cdd:pfam07690  86 ------WLLLVLRVLQGLGAGALFPAALALI-ADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF-LIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  189 GSMAMVLVLSIAGALCVKERVAFEGKKEESYTFRELLQFLRYKPVWALFLVALVVGVGSNIAGGAGAYFYTYILGDMTLM 268
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  269 SGVSLVSMITALVGIFLGPILANRFGKKQIFVMAIVVSILFS---ALRLIDVRSMLLIYISTVAGGVAGGCIAPLTTSIQ 345
Cdd:pfam07690 238 GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAlglLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVS 317
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 31-391 2.82e-06

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 49.38  E-value: 2.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  31 LLSGFFMIYYTNVVGLEPAALATLFL-----ISKVVDGISDPIMGYFLDKfpvtkMGKFRPMIILGTIICVINYILLWF- 104
Cdd:COG2270   29 ITTFVFPPYFTSVAALGDPAAATALWgyalaIAGLLVALLAPVLGAIADR-----SGRKKPFLAFFTLLGVLATAALFFv 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 105 --GAVWIPVGKYVIVYVtylllgwTFDIMDISKNSLLPVMsADDKERNSLSlfnALGTM---IGSAVLAVAAPILVAEGT 179
Cdd:COG2270  104 apGGLWLGLLLFVLANI-------GFEGSLVFYNAFLPDI-ATPEEIGRVS---GLGWAlgyLGGVLLLLINLALFLKPE 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 180 LqnyyvliFGSMAMVLVLSIAGALC--------------VKERVAFEGKKEESY---TFREL---LQFLRYKPVWALFLV 239
Cdd:COG2270  173 A-------FGLPDAGEAVRISFLLTalwwllfalplflfLPERPRPGPAPPRGAvraGFRELrrtLRELRRYRDLLRFLL 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 240 ALVV---GVGSNIAggAGAYFYTYILG-DMTLMSGVSLVSMITALVGIFLGPILANRFGKKQIFVMAIVVSILFSALrLI 315
Cdd:COG2270  246 AYFFyrdGVQTVIA--FAGIYAAGVLGfSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLA-AY 322

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 942017053 316 DVRSMLLIYIstvAGGVAGGCIAPlttsIQADNTTYVQYKTGKRAEAAIASLTSFITKVAQGLGGAIPGYVLAATG 391
Cdd:COG2270  323 FLTTALAFWI---LGLLIGLVMGG----IQALSRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTG 391
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
16-344 5.56e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 48.05  E-value: 5.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  16 MGLFMVCAGNIPLMGLLSGFFMIYYTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKFPvtkmgkFRPMIILGTIIC 95
Cdd:COG2814   12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFG------RRRVLLLGLLLF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  96 VINYILLWFgavwipVGKYVIVYVTYLLLGWTFDIMDISKNSLLPVMsADDKERNSLSLFNALGTMIGSAVLAVAAPILV 175
Cdd:COG2814   86 ALGSLLCAL------APSLWLLLAARFLQGLGAGALFPAALALIADL-VPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 176 AegtLQNYYVLIFGSMAMVLVLSIAGALCVKERVAFEGKKEEsytfRELLQFLRYKPVWALFLVALVVGVGSNIAGGAGA 255
Cdd:COG2814  159 D---LFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLR----GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLP 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 256 YFYTYILG-DMTLMSGVSLVSMITALVGIFLGPILANRFGKKQIFVMAIVVSILFSALrLIDVRSMLLIYISTVAGGVAG 334
Cdd:COG2814  232 LYLQEVLGlSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLL-LALAGSLWLLLLALFLLGFGF 310

                        330
                 ....*....|
gi 942017053 335 GCIAPLTTSI 344
Cdd:COG2814  311 GLLFPLLQAL 320
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
64-370 6.33e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 48.31  E-value: 6.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  64 ISDPIMGYFLDKFPvtkmgkFRPMIILGTIICVINYILLWFGAVwipvgkYVIVYVTYLLLGWTFDIMDISKNSLLPVMS 143
Cdd:COG0738   58 LASLPAGRLIDRFG------YKRGLLLGLLLMALGLLLFALAPS------YPLLLLALFLLGLGLGLLDVAANPYVAALG 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 144 ADDKER--NSLSLFNALGTMIGSAVLAVAAPILVAEGTLQNYYVlifgsMAMVLVLSIAGALCVKERVAFEGKKEESYTF 221
Cdd:COG0738  126 PETAASrlNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLI-----LAVLLLLLALLFLRSKLPEIEEEEEEAAGSA 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 222 RELLQFLRYKPVWALFLVALVVGVGSNIAGGAGAYFYTYILGDMTLMSGVSL-VSMITALVGIFLGPILANRFGKKQIFV 300
Cdd:COG0738  201 ASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLsLFWGGMTIGRFLGGFLLKRFGPVRLLR 280

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 301 MAIVVSILFSALrLIDVRSMLLIYISTVAGGVAGGCIAPLTTSIQADNttyvqykTGKRAEAAIASLTSF 370
Cdd:COG0738  281 LSALLAAVGLLL-ALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDG-------LGKRTAAAVSAVLIM 342
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
229-392 2.84e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.12  E-value: 2.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 229 RYKPVWALFLVALVVGVGSNIAGGAGAYFYTYILGDMTLMSGVSLVSMITALVGIFLGPILANRFGKKQIFVMAIVVSIL 308
Cdd:COG2814    8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 309 FSALRLIdVRSMLLIYISTVAGGVAGGCIAPLTTSIQADNTtyvqykTGKRAEAAIASLTSFITkVAQGLGGAIPGYVLA 388
Cdd:COG2814   88 GSLLCAL-APSLWLLLAARFLQGLGAGALFPAALALIADLV------PPERRGRALGLLGAGLG-LGPALGPLLGGLLAD 159


                 ....
gi 942017053 389 ATGF 392
Cdd:COG2814  160 LFGW 163
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 44-305 4.56e-05

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 45.70  E-value: 4.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  44 VGLEPAALATLFLISKVVDGISDPIMGYFLDKFpVTKMGKFRPMIILGTIICVINYILLWFGAV---WIPVGKYVIVYVT 120
Cdd:cd17313   29 LGLSHALIGFVWTLGPILGLFVQPLVGSLSDRC-NSRIGRRRPFILVGAPLAALGLILIPNAADiglALGDGPRTWALVL 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 121 YLLLGWTFDI-MDISKN---SLLPVMSADDKERNSLSLFN---ALGTMIGSAVLAVAAPILVAEGTLQNYYVLIFGSMAM 193
Cdd:cd17313  108 FVLGIVLLDFaMNVCQGpvrALLPDLVPPEQRSKANGIINfmgGLGGVLGYLLGAILWDHNWFGFALGGNLKVPFYIGAI 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 194 VLVLSIAGALCVKERVAF-------EGKKEESYTFRELLQFLRYKP--VWALFLVALVV-------------GVGSNIAG 251
Cdd:cd17313  188 ILLVCVLVTLFFVKEPPLspeagehSENPSLGEVLKSLLKLLKIMPrsLLRLLLVIFFWwiaffpfelfftdYMGEEVYH 267

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 942017053 252 GAGAYFYTYILGDMTLMSGVSLVSMITALVGIFLGPiLANRFGKKQIFVMAIVV 305
Cdd:cd17313  268 GTSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGK-LGKKIGRKKVYLIGLVL 320
MFS_MFSD12 cd17491
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ...
 34-174 8.61e-05

Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341044  Cd Length: 438  Bit Score: 44.56  E-value: 8.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  34 GFFMIYYTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKfpVTKMGKF-RPMI--ILGTIICVINYILLW---FG-- 105
Cdd:cd17491   20 TYLLVYFHLVLGFSSALAGILLLIGQVADAISTPLVGYESDR--TNGCGKYgRRKSwhLIGTICVLLSFPFIFnpcLGcs 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 942017053 106 ---AVWIPVgKYVIVYVTYLLLGWTFdiMDISKNSLLPVMSADDKERNSLSLFNALGTMIGS-AVLAVAAPIL 174
Cdd:cd17491   98 dstSEWAKL-VYYGPFIIIFQFGWAA--VQISHLSLIPELTSDEHERVELTALRYAFTVIANiTVYLIAWLLL 167
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 35-311 1.22e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 44.14  E-value: 1.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  35 FFMIYYTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKFPvtkmgkFRPMIILGTIICVINYILLWFGAVWIPvgkY 114
Cdd:cd17329   21 FMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFG------RKPVMLAGLLLRALGFALLGFAHSPWL---F 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 115 VIVYVtylLLGWTFDIMDISKNSLLPVMSADDKERNSLSLFNALGTmigsavLAVAAPILVAEGTLQNYYVLIFGSMAMV 194
Cdd:cd17329   92 AIALV---LTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAIN------LGVAIGPLLGGLLLLYSFRLLFLAAAVL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 195 LVLSIAG-ALCVKERVAFEGKKEESYTFRELLQFLRYKPVWALFLVALVVGVGSNIAGGAGAYFYTYILGDMTLMsgVSL 273
Cdd:cd17329  163 FLLAALVlLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESL--LGL 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 942017053 274 VSMITALVGIFLGPILANRFGKKQIFVMAIVVSILFSA 311
Cdd:cd17329  241 LLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAI 278
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 29-202 1.40e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 43.72  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  29 MGLLSGFFMIYYTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKFPvtkmgkFRPMIILGTIICVINYILLWFgavw 108
Cdd:cd17325  215 FGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIG------RKPLILIGLLLSAVALLLLPL---- 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 109 ipVGKYVIVYVTYLLLGWTFDIMDISKNSLLPVMSADDKERNSLSLFNALGTmIGSAVLAVAAPILVAEGTLQNYYVLIF 188
Cdd:cd17325  285 --ATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFS-LGMVLGPLLGGFLYDAFGFATPFLAAA 361

                        170
                 ....*....|....
gi 942017053 189 GSMAMVLVLSIAGA 202
Cdd:cd17325  362 ALLLLAAVLFLLLR 375
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
34-395 2.51e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 42.93  E-value: 2.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  34 GFFMIYYTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKFPVtkmgkfRPMIILGTIICVInyILLWFGAVWipvgK 113
Cdd:COG2271   30 SVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGR------RRVLAIGLLLWGL--ATLLFGFAT----S 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 114 YVIVYVTYLLLGWTFDIMDISKNSLLpVMSADDKERNSLSLFNALGTMIGSAVLAVAAPILVAegtlqnyyvlIFGSMAM 193
Cdd:COG2271   98 FWQLLLLRFLLGLGEAGFFPAALKLI-AEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA----------AFGWRAA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 194 VLVLSIAGALCVkervafegkkeesytfreLLQFlrykpvWALFLVALVVGVGSNIAGGAGAYFYTYILG-DMTLMSGVS 272
Cdd:COG2271  167 FLILGLPGLLLA------------------LLRF------WLLALAYFLVYFALYGFLTWLPTYLVEVRGlSLAQAGLLL 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 273 LVSMITALVGIFLGPILANRFGKKQIFVMAIVVSILFSALRLID-VRSMLLIYISTVAGGVAGGCIAPLTTSIQADNtty 351
Cdd:COG2271  223 SLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLAlLPSPALAIALLFLAGFGLGGAFGLLWALAAEL--- 299

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 942017053 352 vqykTGKRAEAAIASLTSFITKVAQGLGGAIPGYVLAATGFVTG 395
Cdd:COG2271  300 ----FPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339
MFS_Atg22_like cd17483
Autophagy-related protein 22 and similar proteins; member of the Major Facilitator Superfamily ...
 82-309 5.87e-04

Autophagy-related protein 22 and similar proteins; member of the Major Facilitator Superfamily of transporters; Atg22 (also known as Aut4) protein functions as a vacuolar effluxer which mediates the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation. Members of this family belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341036  Cd Length: 467  Bit Score: 42.26  E-value: 5.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  82 GKFRPMIILGTII--CVINYILLWFGAVWIPVGKYVIVYVTYLLLGWTFDIMdiskNSLLPVMSADDK------------ 147
Cdd:cd17483   94 GNYRKRLLLTFTIigSISSILFLFVPSPSLWWLAALLYIVSNICYGASLVFY----NSFLPILARNHPdvraardkgssl 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 148 -----------ERNSLSLFNALGTMIG--SAVLA---VAAPILVAEGTLQNYYVLIFGSMAMVLVLSIAGALCVKERVAF 211
Cdd:cd17483  170 saeateeeislEEKVSSRISSLGFASGyvGGIIVqiiSIIILFVLGNSIVSLRIAIAVVGVWWLIFSVPTFLWLKPRPGP 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 212 EGKKEESY-------TFRELLQFLRYKPVwALFLVA-LVVGVGSNIAGGAGAYFYTYILGDMTLMSGV-SLVSMITALVG 282
Cdd:cd17483  250 PLPGGSHPifyswksLFRTLKHARKLPET-FIFLLAwFFLSDGINTISSTAVLFAKSQLHMSTLQLILiGLLTPITAILG 328

                        250       260
                 ....*....|....*....|....*....
gi 942017053 283 IFLGPILANRF--GKKQIFVMAIVVSILF 309
Cdd:cd17483  329 AFFFPRIQRRFnlSTKTMLMLIVVLTALI 357
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 221-392 9.28e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.38  E-value: 9.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 221 FRELLQFLRYKPVWALFLVALVVGvgsniagGAGAYFYTYI---LGDMTLMSGVS-----LVSMITALVGIFLGPILANR 292
Cdd:cd17324  188 LSSLLLLLRNPRLRLAYLITFLLF-------GGFFALYTYLapfLTDVPGFSSSAiigllLLFGVAGVVGSPLAGRLADR 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 293 FGKKQIFVMAIVVSILFSALRLIDVRSMLLIYISTVAGGVAGGCIAPLTTSIqadnttyvqYKTGKRAEAAIASLTSFIT 372
Cdd:cd17324  261 GGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRV---------LRLAPEARGLASSLYLAAY 331

                        170       180
                 ....*....|....*....|
gi 942017053 373 KVAQGLGGAIPGYVLAATGF 392
Cdd:cd17324  332 NLGGALGAALGGLVLDHGGW 351
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 216-346 9.34e-04

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 41.36  E-value: 9.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 216 EESYTFRELLQFLR--YKPVWALFLV---ALVVGVGSNIAGGAGAYFYT-YILGDMTLMSGVS--------LVSMITALV 281
Cdd:cd17369  200 EETPVFRRAKEAGQvvRAPLVEVLRRhwrALLLAIGLRLAENVLFYLFTtFALSYATQTLGVDrstvllavLIASVVAAI 279

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 942017053 282 GIFLGPILANRFGKKQIFVMAIVVSIL--FSALRLIDVRSMLLIYISTVaggVAGGCIAPLTTSIQA 346
Cdd:cd17369  280 TIPLFGWLSDRVGRRPVYLAGALLAALfaFPFFWLLDTGSTWLIVLAAV---VVLGVLHGMMYGPQA 343
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 39-392 2.78e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 39.87  E-value: 2.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053  39 YYTNVVGLEPAALATLFLISKVVDGISDPIMGYFLDKFpvtkmgKFRPMIILGTIICVINYILLWFgavwipVGKYVIVY 118
Cdd:cd17325   21 LYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRF------GRKRLLLLGLLLLAVSTLLFAF------ATSYWQLL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 119 VTYLLLGWTFDIMDISKNSLLPVMSADDKERNSLSLFNA---LGTMIGSAVLAVAAPILVaegtlqnyYVLIFGSMAMVL 195
Cdd:cd17325   89 LARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSaigLGFLIGPLLGGLLADALG--------YRAPFLVCAALA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 196 VLSIAGALCVKER---VAFEGKKEESYTFRELLQFLRYKPVWALFLVALVVGVGSNIAGGAGAYFYTYILGDMTLMSGVS 272
Cdd:cd17325  161 LLALVLALLLLPEprpPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942017053 273 L-VSMITALVGIFLGPILANRFGKKQIFVMAIVVSILFSALrLIDVRSMLLIYISTVAGGVAGGCIAPLTTSIQADNTTy 351
Cdd:cd17325  241 FgAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLL-LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVP- 318

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 942017053 352 vqyktgKRAEAAIASLTSFITKVAQGLGGAIPGYVLAATGF 392
Cdd:cd17325  319 ------PEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGF 353
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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