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Conserved domains on  [gi|942463857|ref|WP_055319685|]
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hybrid sensor histidine kinase/response regulator [Vibrio crassostreae]

Protein Classification

hybrid sensor histidine kinase/response regulator( domain architecture ID 14293675)

hybrid sensor histidine kinase/response regulator, part of a two-component regulatory system, receives the signal from the sensor partner in a two-component system through its receiver (REC) domain and functions as a protein kinase that phosphorylates a target protein in response to various signals

CATH:  3.40.50.2300|3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0000160|GO:0000156|GO:0000155|GO:0004673|GO:0007165|GO:0005524
PubMed:  20226724|10339418|10637609
SCOP:  4003632|4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 728-845 2.29e-32

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


:

Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 121.88  E-value: 2.29e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 728 PTVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARS--PQTPIIAL 805
Cdd:COG0784    6 KRILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIRALPrlPDIPIIAL 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 942463857 806 SGESGQRELEMINQL-MDGRLEKPTSLNALQHVLDNWLEKD 845
Cdd:COG0784   86 TAYADEEDRERALEAgADDYLTKPVDPEELLEALRRLLARA 126
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 431-682 3.69e-31

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


:

Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 125.68  E-value: 3.69e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 431 DQMFSNEEISALQTLLTRVQSTIEADRR-----IRQSR-----ALANSIAHEMRNPLAQVQLHFEVLKQHIDNQAPAKQI 500
Cdd:COG4191  101 LDAEENAELEELERDITELERAEEELRElqeqlVQSEKlaalgELAAGIAHEINNPLAAILGNAELLRRRLEDEPDPEEL 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 501 LLDIENGQAAIQRGRQLIDIiLREVSDSSPEHgpVTMTSIHKAVDQAVS--HYGFENEKIIERIRLPQHADfVVKLNETL 578
Cdd:COG4191  181 REALERILEGAERAAEIVRS-LRAFSRRDEEE--REPVDLNELIDEALEllRPRLKARGIEVELDLPPDLP-PVLGDPGQ 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 579 FNFVIFNLIRNAIYYFDSYPDSQIEISTKIDSYENVLIFRDTGPGIDEAIAHKIFDDFFS------------YQksggsg 646
Cdd:COG4191  257 LEQVLLNLLINAIDAMEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTtkpvgkgtglglSI------ 330

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 942463857 647 lglgyCQRVMRSFGGRVECHSKLGEFTEFHLYFPVV 682
Cdd:COG4191  331 -----SYGIVEKHGGRIEVESEPGGGTTFTITLPLA 361
 
Name Accession Description Interval E-value
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 728-845 2.29e-32

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 121.88  E-value: 2.29e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 728 PTVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARS--PQTPIIAL 805
Cdd:COG0784    6 KRILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIRALPrlPDIPIIAL 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 942463857 806 SGESGQRELEMINQL-MDGRLEKPTSLNALQHVLDNWLEKD 845
Cdd:COG0784   86 TAYADEEDRERALEAgADDYLTKPVDPEELLEALRRLLARA 126
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 730-838 2.79e-31

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 118.34  E-value: 2.79e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKA---RSPQTPIIALS 806
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLLEKLGYEVDVAENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIRElegGGRRTPIIALT 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 942463857 807 GESGQRELEM-INQLMDGRLEKPTSLNALQHVL 838
Cdd:cd17546   81 ANALEEDREKcLEAGMDDYLSKPVKLDQLKEVL 113
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 431-682 3.69e-31

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 125.68  E-value: 3.69e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 431 DQMFSNEEISALQTLLTRVQSTIEADRR-----IRQSR-----ALANSIAHEMRNPLAQVQLHFEVLKQHIDNQAPAKQI 500
Cdd:COG4191  101 LDAEENAELEELERDITELERAEEELRElqeqlVQSEKlaalgELAAGIAHEINNPLAAILGNAELLRRRLEDEPDPEEL 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 501 LLDIENGQAAIQRGRQLIDIiLREVSDSSPEHgpVTMTSIHKAVDQAVS--HYGFENEKIIERIRLPQHADfVVKLNETL 578
Cdd:COG4191  181 REALERILEGAERAAEIVRS-LRAFSRRDEEE--REPVDLNELIDEALEllRPRLKARGIEVELDLPPDLP-PVLGDPGQ 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 579 FNFVIFNLIRNAIYYFDSYPDSQIEISTKIDSYENVLIFRDTGPGIDEAIAHKIFDDFFS------------YQksggsg 646
Cdd:COG4191  257 LEQVLLNLLINAIDAMEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTtkpvgkgtglglSI------ 330

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 942463857 647 lglgyCQRVMRSFGGRVECHSKLGEFTEFHLYFPVV 682
Cdd:COG4191  331 -----SYGIVEKHGGRIEVESEPGGGTTFTITLPLA 361
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 730-839 5.88e-22

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 91.44  E-value: 5.88e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857  730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSGES 809
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHG 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 942463857  810 gqrELEMINQL----MDGRLEKPTSLNALQHVLD 839
Cdd:pfam00072  81 ---DEDDAVEAleagADDFLSKPFDPDELLAAIR 111
PRK15347 PRK15347
two component system sensor kinase;
460-839 5.60e-20

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 95.48  E-value: 5.60e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 460 RQSRALaNSIAHEMRNPLAQVQLHFEVLKqhiDNQAPAKQI-LLDiengqAAIQRGRQLIDIILREVSDSSPEHGPVTM- 537
Cdd:PRK15347 397 RKSEHL-TTISHEIRTPLNGVLGALELLQ---NTPLTAEQMdLAD-----TARQCTLSLLAIINNLLDFSRIESGQMTLs 467

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 538 ---TSIHKAVDQA------------VSHYGFENEKI-----IERIRLPQhadfvvklnetlfnfVIFNLIRNAIYYFDSY 597
Cdd:PRK15347 468 leeTALLPLLDQAmltiqgpaqsksLTLRTFVGAHVplylhLDSLRLRQ---------------ILVNLLGNAVKFTETG 532

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 598 pdsqiEISTKIDSYENVLIFR--DTGPGIDEAIAHKIFDDFFSYQKSGGSGLG-LGYCQRVMRSFGGRVECHSKLGEFTE 674
Cdd:PRK15347 533 -----GIRLRVKRHEQQLCFTveDTGCGIDIQQQQQIFTPFYQADTHSQGTGLgLTIASSLAKMMGGELTLFSTPGVGSC 607

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 675 FHLYFPV----VPN-------APKA-------------DALRTPYFND----------WKHNQTTTQdktCADTQPTSSr 720
Cdd:PRK15347 608 FSLVLPLneyaPPEplkgelsAPLAlhrqlsawgitcqPGHQNPALLDpelaylpgrlYDLLQQIIQ---GAPNEPVIN- 683

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 721 eseshlAPT------VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQI-- 792
Cdd:PRK15347 684 ------LPLqpwqlqILLVDDVETNRDIIGMMLVELGQQVTTAASGTEALELGRQHRFDLVLMDIRMPGLDGLETTQLwr 757

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 942463857 793 --IKARSPQTPIIALSGESGQRELEMINQL-MDGRLEKPTSLNALQHVLD 839
Cdd:PRK15347 758 ddPNNLDPDCMIVALTANAAPEEIHRCKKAgMNHYLTKPVTLAQLARALE 807
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 711-841 8.96e-19

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 91.83  E-value: 8.96e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 711 CADTQPTSSRESESHLAP-TVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDA 789
Cdd:PRK11107 650 CHHKQPPLLPPTDESRLPlTVMAVDDNPANLKLIGALLEEQVEHVVLCDSGHQAVEQAKQRPFDLILMDIQMPGMDGIRA 729

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 942463857 790 SQIIKARS--PQTPIIALSGE--SGQRElEMINQLMDGRLEKPTSLNALQHVLDNW 841
Cdd:PRK11107 730 CELIRQLPhnQNTPIIAVTAHamAGERE-RLLSAGMDDYLAKPIDEAMLKQVLLRY 784
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 575-681 6.60e-18

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 80.00  E-value: 6.60e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857   575 NETLFNFVIFNLIRNAIYYfdSYPDSQIEISTKIDSYENVLIFRDTGPGIDEAIAHKIFDDFFSYQKSGGSGLGL----G 650
Cdd:smart00387   2 DPDRLRQVLSNLLDNAIKY--TPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTglglS 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 942463857   651 YCQRVMRSFGGRVECHSKLGEFTEFHLYFPV 681
Cdd:smart00387  80 IVKKLVELHGGEISVESEPGGGTTFTITLPL 110
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 582-679 9.85e-18

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 79.18  E-value: 9.85e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 582 VIFNLIRNAIYYfdSYPDSQIEISTKIDSYENVLIFRDTGPGIDEAIAHKIFDDFFSYQKSGGSGLG---LGYCQRVMRS 658
Cdd:cd00075    4 VLSNLLDNALKY--SPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTglgLAIVRRIVEA 81

                         90       100
                 ....*....|....*....|.
gi 942463857 659 FGGRVECHSKLGEFTEFHLYF 679
Cdd:cd00075   82 HGGRITVESEPGGGTTFTVTL 102
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 728-782 2.36e-13

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 65.28  E-value: 2.36e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 942463857   728 PTVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMP 782
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLKEEKPDLILLDIMMP 55
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 582-683 1.15e-11

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 62.00  E-value: 1.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857  582 VIFNLIRNAIYYfdSYPDSQIEISTKIDSyENVLIFRDTGPGIDEAIAHKIFDDFFSYQKSGGSGLGL--GYCQRVMRSF 659
Cdd:pfam02518   9 VLSNLLDNALKH--AAKAGEITVTLSEGG-ELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGGTGLglSIVRKLVELL 85

                          90       100
                  ....*....|....*....|....
gi 942463857  660 GGRVECHSKLGEFTEFHLYFPVVP 683
Cdd:pfam02518  86 GGTITVESEPGGGTTVTLTLPLAQ 109
 
Name Accession Description Interval E-value
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 728-845 2.29e-32

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 121.88  E-value: 2.29e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 728 PTVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARS--PQTPIIAL 805
Cdd:COG0784    6 KRILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIRALPrlPDIPIIAL 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 942463857 806 SGESGQRELEMINQL-MDGRLEKPTSLNALQHVLDNWLEKD 845
Cdd:COG0784   86 TAYADEEDRERALEAgADDYLTKPVDPEELLEALRRLLARA 126
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 730-838 2.79e-31

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 118.34  E-value: 2.79e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKA---RSPQTPIIALS 806
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLLEKLGYEVDVAENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIRElegGGRRTPIIALT 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 942463857 807 GESGQRELEM-INQLMDGRLEKPTSLNALQHVL 838
Cdd:cd17546   81 ANALEEDREKcLEAGMDDYLSKPVKLDQLKEVL 113
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 431-682 3.69e-31

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 125.68  E-value: 3.69e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 431 DQMFSNEEISALQTLLTRVQSTIEADRR-----IRQSR-----ALANSIAHEMRNPLAQVQLHFEVLKQHIDNQAPAKQI 500
Cdd:COG4191  101 LDAEENAELEELERDITELERAEEELRElqeqlVQSEKlaalgELAAGIAHEINNPLAAILGNAELLRRRLEDEPDPEEL 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 501 LLDIENGQAAIQRGRQLIDIiLREVSDSSPEHgpVTMTSIHKAVDQAVS--HYGFENEKIIERIRLPQHADfVVKLNETL 578
Cdd:COG4191  181 REALERILEGAERAAEIVRS-LRAFSRRDEEE--REPVDLNELIDEALEllRPRLKARGIEVELDLPPDLP-PVLGDPGQ 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 579 FNFVIFNLIRNAIYYFDSYPDSQIEISTKIDSYENVLIFRDTGPGIDEAIAHKIFDDFFS------------YQksggsg 646
Cdd:COG4191  257 LEQVLLNLLINAIDAMEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTtkpvgkgtglglSI------ 330

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 942463857 647 lglgyCQRVMRSFGGRVECHSKLGEFTEFHLYFPVV 682
Cdd:COG4191  331 -----SYGIVEKHGGRIEVESEPGGGTTFTITLPLA 361
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 727-839 1.19e-25

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 104.61  E-value: 1.19e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 727 APTVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKA--RSPQTPIIA 804
Cdd:COG3706    1 PARILVVDDDPTNRKLLRRLLEAAGYEVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRAdpRTADIPIIF 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 942463857 805 LSGESGQRELEMINQL-MDGRLEKPTSLNALQHVLD 839
Cdd:COG3706   81 LTALDDEEDRARALEAgADDYLTKPFDPEELLARVD 116
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
454-684 1.68e-25

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 106.14  E-value: 1.68e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 454 EADRRIRQSRALANSIAHEMRNPLAQVQLHFEVLKQHIDNQAPAKQILLDIengqaAIQRGRQLIDII--LREVSDSSPE 531
Cdd:COG2205    8 ELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEI-----IRESAERLLRLIedLLDLSRLESG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 532 HGPVTMT--SIHKAVDQAVSHYG--FENEKIIERIRLPQhADFVVKLNETLFNFVIFNLIRNAIYYfdSYPDSQIEISTK 607
Cdd:COG2205   83 KLSLELEpvDLAELLEEAVEELRplAEEKGIRLELDLPP-ELPLVYADPELLEQVLANLLDNAIKY--SPPGGTITISAR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 608 IDSYENVLIFRDTGPGIDEAIAHKIFDDFFSYQKSGGSGLG---LGYCQRVMRSFGGRVECHSKLGEFTEFHLYFPVVPN 684
Cdd:COG2205  160 REGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTglgLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAES 239
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
437-681 3.30e-25

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 107.69  E-value: 3.30e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 437 EEISALQTLLTRVQSTIEADRRIRQSRALANSIAHEMRNPLAQVQLHFEVLKQHIDnqAPAKQILLDIENgqaAIQRGRQ 516
Cdd:COG0642   85 LLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELD--EEQREYLETILR---SADRLLR 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 517 LIDIILR----EVSDSSPEHGPVtmtSIHKAVDQAVSHYGFE-NEKIIE-RIRLPQHADfVVKLNETLFNFVIFNLIRNA 590
Cdd:COG0642  160 LINDLLDlsrlEAGKLELEPEPV---DLAELLEEVVELFRPLaEEKGIElELDLPDDLP-TVRGDPDRLRQVLLNLLSNA 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 591 IYYfdSYPDSQIEISTKIDSYENVLIFRDTGPGIDEAIAHKIFDDFFSYQKSGGSGLG---LGYCQRVMRSFGGRVECHS 667
Cdd:COG0642  236 IKY--TPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTglgLAIVKRIVELHGGTIEVES 313

                        250
                 ....*....|....
gi 942463857 668 KLGEFTEFHLYFPV 681
Cdd:COG0642  314 EPGKGTTFTVTLPL 327
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 727-843 4.64e-23

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 98.31  E-value: 4.64e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 727 APTVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSP--QTPIIA 804
Cdd:COG3437    6 APTVLIVDDDPENLELLRQLLRTLGYDVVTAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLRADPStrDIPVIF 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 942463857 805 LSGESGQR-ELEMINQLMDGRLEKPTSLNALQHVLDNWLE 843
Cdd:COG3437   86 LTALADPEdRERALEAGADDYLTKPFDPEELLARVRNALE 125
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 728-844 8.44e-23

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 101.96  E-value: 8.44e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 728 PTVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSG 807
Cdd:COG2204    3 ARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVILLTG 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 942463857 808 ESgqrELEMINQLM----DGRLEKPTSLNALQHVLDNWLEK 844
Cdd:COG2204   83 YG---DVETAVEAIkagaFDYLTKPFDLEELLAAVERALER 120
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 731-828 1.90e-22

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 92.68  E-value: 1.90e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 731 LIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSGESG 810
Cdd:cd00156    1 LIVDDDPAIRELLKSLLEREGYEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAKAD 80

                         90
                 ....*....|....*....
gi 942463857 811 -QRELEMINQLMDGRLEKP 828
Cdd:cd00156   81 eEDAVRALELGADDYLVKP 99
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 729-828 4.03e-22

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 91.76  E-value: 4.03e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 729 TVLIVDDKEVQRTLVQMYLSRLG--VNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALS 806
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILEWEAgfEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIILS 80

                         90       100
                 ....*....|....*....|....*.
gi 942463857 807 GESgqrELEMINQLM----DGRLEKP 828
Cdd:COG4753   81 GYS---DFEYAQEAIklgaDDYLLKP 103
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 730-839 5.88e-22

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 91.44  E-value: 5.88e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857  730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSGES 809
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHG 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 942463857  810 gqrELEMINQL----MDGRLEKPTSLNALQHVLD 839
Cdd:pfam00072  81 ---DEDDAVEAleagADDFLSKPFDPDELLAAIR 111
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 728-834 1.36e-21

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 93.48  E-value: 1.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 728 PTVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSG 807
Cdd:COG0745    2 PRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLTA 81

                         90       100
                 ....*....|....*....|....*...
gi 942463857 808 ESGQRE-LEMINQLMDGRLEKPTSLNAL 834
Cdd:COG0745   82 RDDEEDrVRGLEAGADDYLTKPFDPEEL 109
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
454-688 1.58e-21

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 97.22  E-value: 1.58e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 454 EADRRIRQS------RALANSIAHEMRNPLAQVQLHFEVLKQHIDNqaPAKQILLD-IENgqaAIQRGRQLIDIILREVS 526
Cdd:COG3852  121 RLERELRRAeklaavGELAAGLAHEIRNPLTGIRGAAQLLERELPD--DELREYTQlIIE---EADRLNNLVDRLLSFSR 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 527 DSSPEHGPVtmtSIHKAVDQAVS--HYGFENEKIIER---IRLPQhadfvVKLNETLFNFVIFNLIRNAIyyfDSYPDS- 600
Cdd:COG3852  196 PRPPEREPV---NLHEVLERVLEllRAEAPKNIRIVRdydPSLPE-----VLGDPDQLIQVLLNLVRNAA---EAMPEGg 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 601 QIEISTKIDSYEN----------VLIFRDTGPGIDEAIAHKIFDDFFSyqksggsglglgyCQRVMRSFGGRVECHSKLG 670
Cdd:COG3852  265 TITIRTRVERQVTlgglrprlyvRIEVIDNGPGIPEEILDRIFEPFFTtkekgt-glglaiVQKIVEQHGGTIEVESEPG 343

                        250
                 ....*....|....*...
gi 942463857 671 EFTEFHLYFPVVPNAPKA 688
Cdd:COG3852  344 KGTTFRIYLPLEQAEEEP 361
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 728-807 4.19e-21

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 89.18  E-value: 4.19e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 728 PTVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSG 807
Cdd:cd17555    1 ATILVIDDDEVVRESIAAYLEDSGFQVLQAADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPDTPVIVVSG 80
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 729-828 2.79e-20

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 86.83  E-value: 2.79e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 729 TVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKArSPQT---PIIAL 805
Cdd:cd17548    1 KILIVEDNPLNMKLARDLLESAGYEVLEAADGEEALEIARKEKPDLILMDIQLPGMDGLEATRLLKE-DPATrdiPVIAL 79

                         90       100
                 ....*....|....*....|....*
gi 942463857 806 SGE--SGQRElEMINQLMDGRLEKP 828
Cdd:cd17548   80 TAYamKGDRE-KILEAGCDGYISKP 103
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 729-844 2.82e-20

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 87.72  E-value: 2.82e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 729 TVLIVDDKEVQRTLVQMYLSRLGVNSL--QAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALS 806
Cdd:COG4565    5 RVLIVEDDPMVAELLRRYLERLPGFEVvgVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDVIVIT 84

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 942463857 807 GESGQREL-EMINQLMDGRLEKPTSLNALQHVLDNWLEK 844
Cdd:COG4565   85 AARDPETVrEALRAGVVDYLIKPFTFERLREALERYLEY 123
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 465-686 4.81e-20

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 93.49  E-value: 4.81e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 465 LANSIAHEMRNPLAQVQLHFEVLKQHIDNQapakqilldIENGQAAIQRGrqlIDIILREVSD--------------SSP 530
Cdd:COG5000  204 LARRIAHEIKNPLTPIQLSAERLRRKLADK---------LEEDREDLERA---LDTIIRQVDRlkrivdefldfarlPEP 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 531 EHGPVTMTSIhkaVDQAVSHYGFENEKIIERIRLPQHADF-VVKLNETLFNFVIFNLIRNAIyyfDSYPDS-QIEISTKI 608
Cdd:COG5000  272 QLEPVDLNEL---LREVLALYEPALKEKDIRLELDLDPDLpEVLADRDQLEQVLINLLKNAI---EAIEEGgEIEVSTRR 345

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 942463857 609 DSYENVLIFRDTGPGIDEAIAHKIFDDFFSyqksggsglglGYCQRVMRSFGGRVECHSKLGEFTEFHLYFPVVPNAP 686
Cdd:COG5000  346 EDGRVRIEVSDNGPGIPEEVLERIFEPFFTtkpkg-tglglAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
PRK15347 PRK15347
two component system sensor kinase;
460-839 5.60e-20

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 95.48  E-value: 5.60e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 460 RQSRALaNSIAHEMRNPLAQVQLHFEVLKqhiDNQAPAKQI-LLDiengqAAIQRGRQLIDIILREVSDSSPEHGPVTM- 537
Cdd:PRK15347 397 RKSEHL-TTISHEIRTPLNGVLGALELLQ---NTPLTAEQMdLAD-----TARQCTLSLLAIINNLLDFSRIESGQMTLs 467

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 538 ---TSIHKAVDQA------------VSHYGFENEKI-----IERIRLPQhadfvvklnetlfnfVIFNLIRNAIYYFDSY 597
Cdd:PRK15347 468 leeTALLPLLDQAmltiqgpaqsksLTLRTFVGAHVplylhLDSLRLRQ---------------ILVNLLGNAVKFTETG 532

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 598 pdsqiEISTKIDSYENVLIFR--DTGPGIDEAIAHKIFDDFFSYQKSGGSGLG-LGYCQRVMRSFGGRVECHSKLGEFTE 674
Cdd:PRK15347 533 -----GIRLRVKRHEQQLCFTveDTGCGIDIQQQQQIFTPFYQADTHSQGTGLgLTIASSLAKMMGGELTLFSTPGVGSC 607

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 675 FHLYFPV----VPN-------APKA-------------DALRTPYFND----------WKHNQTTTQdktCADTQPTSSr 720
Cdd:PRK15347 608 FSLVLPLneyaPPEplkgelsAPLAlhrqlsawgitcqPGHQNPALLDpelaylpgrlYDLLQQIIQ---GAPNEPVIN- 683

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 721 eseshlAPT------VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQI-- 792
Cdd:PRK15347 684 ------LPLqpwqlqILLVDDVETNRDIIGMMLVELGQQVTTAASGTEALELGRQHRFDLVLMDIRMPGLDGLETTQLwr 757

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 942463857 793 --IKARSPQTPIIALSGESGQRELEMINQL-MDGRLEKPTSLNALQHVLD 839
Cdd:PRK15347 758 ddPNNLDPDCMIVALTANAAPEEIHRCKKAgMNHYLTKPVTLAQLARALE 807
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 731-809 2.92e-19

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 83.23  E-value: 2.92e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 731 LIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPII---ALSG 807
Cdd:cd17574    1 LVVEDDEEIAELLSDYLEKEGYEVDTAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIImltAKDE 80


                 ..
gi 942463857 808 ES 809
Cdd:cd17574   81 EE 82
KinC COG5807
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ...
 436-682 4.55e-19

Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444509 [Multi-domain]  Cd Length: 358  Bit Score: 89.84  E-value: 4.55e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 436 NEEISALQTLLTRVQSTIEADRRIRQSRAL------ANSIAHEMRNPLAQVQLHFEVLKQHI--DNQAPAKQILLDieng 507
Cdd:COG5807  115 DGVILGLITVYRDITKRKEAEDKLLRSEKLsvagelAAGIAHEIRNPLTSIKGFLQLLQESRedSEREEYFNIIIS---- 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 508 qaAIQRGRQLIDIILrevSDSSPEHGPVTMTSIHKAVDQ--AVSHYGFENEKIIERIRLPQHaDFVVKLNETLFNFVIFN 585
Cdd:COG5807  191 --EIDRINTIITELL---VLSKPKKFNFKKLNLNDVLEDviALLSTEAILKNISIKYDLADD-EPVINGDKNQLKQVFIN 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 586 LIRNAIyyfDSYPDS-QIEISTKIDSYENVLIFRDTGPGIDEAIAHKIFDDFFSyQKSGGSGLGLGYCQRVMRSFGGRVE 664
Cdd:COG5807  265 LIKNAI---EAMETGgNITIKTYVEGDFVVISVKDEGIGIPEEVLEKIGEPFFT-TKEEGTGLGLSICKKIIEEHNGTIE 340

                        250
                 ....*....|....*...
gi 942463857 665 CHSKLGEFTEFHLYFPVV 682
Cdd:COG5807  341 VESKPGKGTTFTIYLPLY 358
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 711-841 8.96e-19

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 91.83  E-value: 8.96e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 711 CADTQPTSSRESESHLAP-TVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDA 789
Cdd:PRK11107 650 CHHKQPPLLPPTDESRLPlTVMAVDDNPANLKLIGALLEEQVEHVVLCDSGHQAVEQAKQRPFDLILMDIQMPGMDGIRA 729

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 942463857 790 SQIIKARS--PQTPIIALSGE--SGQRElEMINQLMDGRLEKPTSLNALQHVLDNW 841
Cdd:PRK11107 730 CELIRQLPhnQNTPIIAVTAHamAGERE-RLLSAGMDDYLAKPIDEAMLKQVLLRY 784
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 729-807 1.06e-18

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 82.16  E-value: 1.06e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 729 TVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARsPQT---PII-- 803
Cdd:cd17538    1 KILVVDDEPANRELLEALLSAEGYEVLTADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLKED-PETrhiPVImi 79


                 ....*
gi 942463857 804 -ALSG 807
Cdd:cd17538   80 tALDD 84
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 730-807 2.06e-18

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 81.61  E-value: 2.06e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYL--SRLGVNS-LQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALS 806
Cdd:cd17536    1 VLIVDDEPLIREGLKKLIdwEELGFEVvGEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIILS 80


                 .
gi 942463857 807 G 807
Cdd:cd17536   81 G 81
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 200-684 4.54e-18

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 88.30  E-value: 4.54e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 200 LVFMLSTATIHLGMTYFLRDFSLTWLPPALSISEMLFVGYALLTSRFYSVKYLAYMSLNALLVCAILVIPFGAIFIPLTE 279
Cdd:COG4251   10 LLLLLLLLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLEL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 280 DNQWLIAIPICALIGITWHVLYKRVSRYASFFVYGNKTTPVQQILALEEDFKLSIDDAMRRLGSLLQIPEDKLRLVNSNY 359
Cdd:COG4251   90 ALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILA 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 360 NETFYEDYLSTSKSVLVFDELSEELDYTAPAKRSINALYEKMSSNNTALVMPLFGQGKSVTHLLVSSHKSNDQMFSNEEI 439
Cdd:COG4251  170 LLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLI 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 440 SALQTLLTRVQSTIEADRRIRQSRAL----------ANSIAHEMRNPLAQVQLHFEVLKQHIDNQAPAKqILLDIENGQA 509
Cdd:COG4251  250 LVLELLELRLELEELEEELEERTAELersneeleqfAYVASHDLREPLRKISGFSQLLEEDYGDKLDEE-GREYLERIRD 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 510 AIQRGRQLIDIILR--EVSDSSPEHGPVTMTSIHKAVDQAVSHYGFENEKIIERIRLPqhadfVVKLNETLFNFVIFNLI 587
Cdd:COG4251  329 AAERMQALIDDLLAysRVGRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLP-----TVRGDPTLLRQVFQNLI 403

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 588 RNAIYYFDSYPDSQIEISTKIDSYENVLIFRDTGPGIDEAIAHKIFDDFfsyQKsggSGLGLGY---------CQRVMRS 658
Cdd:COG4251  404 SNAIKYSRPGEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIF---QR---LHSRDEYegtgiglaiVKKIVER 477

                        490       500
                 ....*....|....*....|....*.
gi 942463857 659 FGGRVECHSKLGEFTEFHLYFPVVPN 684
Cdd:COG4251  478 HGGRIWVESEPGEGATFYFTLPKAPA 503
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 730-838 5.44e-18

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 80.25  E-value: 5.44e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSR-LGVN-SLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALsg 807
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESePDIEvVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVL-- 78

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 942463857 808 eSGQRELEMINQLMD----GRLEKPTS----LNALQHVL 838
Cdd:cd17535   79 -TAHDDPEYVLRALKagaaGYLLKDSSpeelIEAIRAVA 116
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 575-681 6.60e-18

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 80.00  E-value: 6.60e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857   575 NETLFNFVIFNLIRNAIYYfdSYPDSQIEISTKIDSYENVLIFRDTGPGIDEAIAHKIFDDFFSYQKSGGSGLGL----G 650
Cdd:smart00387   2 DPDRLRQVLSNLLDNAIKY--TPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTglglS 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 942463857   651 YCQRVMRSFGGRVECHSKLGEFTEFHLYFPV 681
Cdd:smart00387  80 IVKKLVELHGGEISVESEPGGGTTFTITLPL 110
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 728-813 9.53e-18

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 79.57  E-value: 9.53e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 728 PTVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSG 807
Cdd:cd17554    1 KKILVVDDEENIRELYKEELEDEGYEVVTAGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDLPVIICTA 80


                 ....*.
gi 942463857 808 ESGQRE 813
Cdd:cd17554   81 YSEYKS 86
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 582-679 9.85e-18

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 79.18  E-value: 9.85e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 582 VIFNLIRNAIYYfdSYPDSQIEISTKIDSYENVLIFRDTGPGIDEAIAHKIFDDFFSYQKSGGSGLG---LGYCQRVMRS 658
Cdd:cd00075    4 VLSNLLDNALKY--SPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTglgLAIVRRIVEA 81

                         90       100
                 ....*....|....*....|.
gi 942463857 659 FGGRVECHSKLGEFTEFHLYF 679
Cdd:cd00075   82 HGGRITVESEPGGGTTFTVTL 102
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
322-684 1.18e-17

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 86.14  E-value: 1.18e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 322 QILALEEDFKLSIDDAMRRLGSLLQIPEDKLRLVNSNYNETFYEDYLSTSKSVLVFDELSEELDYTAPAKRSINALYEKM 401
Cdd:COG5002   24 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLI 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 402 SSNNTALVMPLFGQGKSVTHLLVSSHKSNDQMFSNEEISALQTLLTRVQSTIEADRRIRQSRA--LANsIAHEMRNPLAQ 479
Cdd:COG5002  104 LLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRRefVAN-VSHELRTPLTS 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 480 VQLHFEVLKQHIDNQAPAKQILLDIENGQAaiQRGRQLIDIILrEVS--DSSPEHGPVTMTSIHKAVDQAVSHYGFENEK 557
Cdd:COG5002  183 IRGYLELLLDGAADDPEERREYLEIILEEA--ERLSRLVNDLL-DLSrlESGELKLEKEPVDLAELLEEVVEELRPLAEE 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 558 iiERIRL---PQHADFVVKLNETLFNFVIFNLIRNAIYYfdSYPDSQIEISTKIDSYENVLIFRDTGPGIDEAIAHKIFD 634
Cdd:COG5002  260 --KGIELeldLPEDPLLVLGDPDRLEQVLTNLLDNAIKY--TPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFE 335

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 942463857 635 DFFSYQKSGGSGL-----GLGYCQRVMRSFGGRVECHSKLGEFTEFHLYFPVVPN 684
Cdd:COG5002  336 RFYRVDKSRSRETggtglGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 730-807 3.48e-17

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 78.20  E-value: 3.48e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSR------LGVnslqAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPqTPII 803
Cdd:cd17541    3 VLIVDDSAVMRKLLSRILESdpdievVGT----ARDGEEALEKIKELKPDVITLDIEMPVMDGLEALRRIMAERP-TPVV 77


                 ....
gi 942463857 804 ALSG 807
Cdd:cd17541   78 MVSS 81
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 582-858 4.03e-17

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 86.15  E-value: 4.03e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 582 VIFNLIRNAIYYFDsypdsQIEISTKIdSYEN--VLIFR--DTGPGIDEAIAHKIFDDFfsYQKSGGSGLGLG------- 650
Cdd:PRK11091 402 ILWNLISNAVKFTQ-----QGGVTVRV-RYEEgdMLTFEveDSGIGIPEDELDKIFAMY--YQVKDSHGGKPAtgtgigl 473

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 651 -YCQRVMRSFGGRVECHSKLGEFTEFHLYFPVvpnapkadalrtpyfndwkhnqtttqdkTCADTQPTSSRESESHLAPT 729
Cdd:PRK11091 474 aVSKRLAQAMGGDITVTSEEGKGSCFTLTIHA----------------------------PAVAEEVEDAFDEDDMPLPA 525

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 --VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQ---TPIIA 804
Cdd:PRK11091 526 lnILLVEDIELNVIVARSVLEKLGNSVDVAMTGKEALEMFDPDEYDLVLLDIQLPDMTGLDIARELRERYPRedlPPLVA 605

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 942463857 805 LSGESGQRELEMINQLMDGRLEKPTSLNALQHVLDN-WLEKDWASNASKEAEGEE 858
Cdd:PRK11091 606 LTANVLKDKKEYLDAGMDDVLSKPLSVPALTAMIKKfWDTQDDEESTVTTEESSK 660
Spo0F COG5803
Stage 0 sporulation initiation response regulator Spo0F [Cell cycle control, cell division, ...
 729-821 5.89e-17

Stage 0 sporulation initiation response regulator Spo0F [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444505 [Multi-domain]  Cd Length: 119  Bit Score: 77.53  E-value: 5.89e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 729 TVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSGE 808
Cdd:COG5803    4 KILIVDDQAGIRMLLKEVLKKEGYEVFQAANGKEALEKVKELKPDLVLLDMKMPGMDGIEILKEIKEIDPDIPVIMMTAY 83

                         90
                 ....*....|...
gi 942463857 809 SgqrELEMINQLM 821
Cdd:COG5803   84 G---ELDMVEEAK 93
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 728-828 7.35e-17

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 77.32  E-value: 7.35e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 728 PTVLIVDDKEVQRTLVQMYLSRLGVNSL-QAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALS 806
Cdd:cd17542    1 KKVLIVDDAAFMRMMLKDILTKAGYEVVgEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIMCS 80

                         90       100
                 ....*....|....*....|....
gi 942463857 807 GeSGQREL--EMINQLMDGRLEKP 828
Cdd:cd17542   81 A-MGQEEMvkEAIKAGAKDFIVKP 103
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
727-806 4.32e-16

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 81.82  E-value: 4.32e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 727 APTVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALS 806
Cdd:PRK11361   4 INRILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILMT 83
KinD COG5808
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ...
 443-682 1.72e-15

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444510 [Multi-domain]  Cd Length: 454  Bit Score: 79.79  E-value: 1.72e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 443 QTLLTRVQSTIEADRrIRQSRALANSIAHEMRNPLAQVQLHFEVLK-QHIDNQapaKQILLDIengqaaIQrgrQLIDII 521
Cdd:COG5808  223 KTLLERVIQEINTQK-LELIGTFAASTAHEIRNPLTSIKGFIQLLQeKYPELE---DQKYFDI------IQ---EEIQRI 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 522 LREVSD----SSPEHGPVTMTSIHKAVDQAVS--HYGFENEKIIERIRLPQHaDFVVKLNETLFNFVIFNLIRNAIYYFD 595
Cdd:COG5808  290 NQIVSEflvlGKPTAKKLELDDLNELIEEILSiiDSEANLKNIRVEKQSLDE-PLHIKCDKDRIKQVLLNLIKNAIEAMK 368

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 596 SypDSQIEISTKIDSYENVLIFRDTGPGIDEAIAHKIFDDFFSyQKSGGSGLGLGYCQRVMRSFGGRVECHSKLGEFTEF 675
Cdd:COG5808  369 E--GGKLTISIENDDEKAVIEVIDNGEGIPEDIIDEIFEPFVT-TKEGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTF 445


                 ....*..
gi 942463857 676 HLYFPVV 682
Cdd:COG5808  446 TIRLPLK 452
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 730-807 1.01e-14

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 70.99  E-value: 1.01e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSG 807
Cdd:cd17550    1 ILIVDDEEDIRESLSGILEDEGYEVDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIMISG 78
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 729-803 2.07e-14

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 73.70  E-value: 2.07e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 942463857 729 TVLIVDDKEVQRTLVQMYLSRLGVNSL--QAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPII 803
Cdd:COG3279    3 KILIVDDEPLARERLERLLEKYPDLEVvgEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPII 79
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 730-814 2.97e-14

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 69.75  E-value: 2.97e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSL-QAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPqTPIIALSGE 808
Cdd:cd19932    3 VLIAEDEALIRMDLREMLEEAGYEVVgEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENI-APIVLLTAY 81


                 ....*.
gi 942463857 809 SgQREL 814
Cdd:cd19932   82 S-QQDL 86
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 730-838 8.46e-14

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 68.25  E-value: 8.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSP--QTPIIALSG 807
Cdd:cd17580    1 ILVVDDNEDAAEMLALLLELEGAEVTTAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLRELPWlaNTPAIALTG 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 942463857 808 eSGQRElEMINQL---MDGRLEKPTSLNALQHVL 838
Cdd:cd17580   81 -YGQPE-DRERALeagFDAHLVKPVDPDELIELI 112
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 728-782 2.36e-13

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 65.28  E-value: 2.36e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 942463857   728 PTVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMP 782
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLKEEKPDLILLDIMMP 55
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 730-806 9.01e-13

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 65.22  E-value: 9.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKArSPQT---PIIALS 806
Cdd:cd19920    1 ILIVDDVPDNLRLLSELLRAAGYRVLVATDGQQALQRAQAEPPDLILLDVMMPGMDGFEVCRRLKA-DPATrhiPVIFLT 79
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 727-809 9.57e-13

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 67.25  E-value: 9.57e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 727 APTVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALS 806
Cdd:COG4567    4 DRSLLLVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVVLT 83


                 ...
gi 942463857 807 GES 809
Cdd:COG4567   84 GYA 86
orf27 CHL00148
Ycf27; Reviewed
 730-807 1.04e-12

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 68.59  E-value: 1.04e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSpQTPIIALSG 807
Cdd:CHL00148   9 ILVVDDEAYIRKILETRLSIIGYEVITASDGEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEIRKES-DVPIIMLTA 85
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 730-838 1.20e-12

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 65.25  E-value: 1.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSR-LGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSGE 808
Cdd:cd17593    3 VLICDDSSMARKQLARALPAdWDVEITFAENGEEALEILREGRIDVLFLDLTMPVMDGYEVLEALPVEQLETKVIVVSGD 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 942463857 809 SGQRELEMINQL-MDGRLEKPTSLNALQHVL 838
Cdd:cd17593   83 VQPEAKERVLELgALAFLKKPFDPEKLAQLL 113
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 728-843 1.40e-12

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 65.12  E-value: 1.40e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 728 PTVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSG 807
Cdd:cd17569    1 PTILLVDDEPNILKALKRLLRREGYEVLTATSGEEALEILKQEPVDVVISDQRMPGMDGAELLKRVRERYPDTVRILLTG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 942463857 808 ESGQREL-EMINQlmdGR----LEKPTSLNALQHVLDNWLE 843
Cdd:cd17569   81 YADLDAAiEAINE---GEiyrfLTKPWDDEELKETIRQALE 118
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 465-686 1.43e-12

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 70.77  E-value: 1.43e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 465 LANSIAHEMRNPLAqvqlhfeVLKQHIdnqapakQILLDIENGQaaiqrGRQLIDIILRE-------VSD----SSPEHG 533
Cdd:COG5809  273 LAAGIAHEIRNPLT-------SLKGFI-------QLLKDTIDEE-----QKTYLDIMLSEldriesiISEflvlAKPQAI 333

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 534 PVTMTSIHKAVDQAVSHygFENEKIIERIRLpqHADFV-----VKLNETLFNFVIFNLIRNAIyyfDSYPDS-QIEISTK 607
Cdd:COG5809  334 KYEPKDLNTLIEEVIPL--LQPQALLKNVQI--ELELEddipdILGDENQLKQVFINLLKNAI---EAMPEGgNITIETK 406

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 608 IDSYENVLI-FRDTGPGIDEAIAHKIFDDFFSyQKSGGSGLGLGYCQRVMRSFGGRVECHSKLGEFTEFHLYFPVVPNAP 686
Cdd:COG5809  407 AEDDDKVVIsVTDEGCGIPEERLKKLGEPFYT-TKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKLSEQ 485
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 730-835 1.89e-12

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 64.61  E-value: 1.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSpQTPIIALSGES 809
Cdd:cd18159    1 ILIVEDDETIASLLKKHLEKWGYEVVLIEDFEDVLEEFLQFKPDLVLLDINLPYFDGFYWCREIRQIS-NVPIIFISSRD 79

                         90       100
                 ....*....|....*....|....*..
gi 942463857 810 GQRELEM-INQLMDGRLEKPTSLNALQ 835
Cdd:cd18159   80 DNMDQVMaINMGGDDYITKPFDLDVLL 106
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 729-824 2.06e-12

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 64.91  E-value: 2.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 729 TVLIVDDKEVQRTLVQMYLSRLGVNSL--QAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIkarspqtpiiaLS 806
Cdd:COG2197    3 RVLIVDDHPLVREGLRALLEAEPDIEVvgEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL-----------LT 71

                         90
                 ....*....|....*...
gi 942463857 807 gesgQRELEMINQLMDGR 824
Cdd:COG2197   72 ----PREREVLRLLAEGL 85
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 729-810 3.20e-12

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 63.86  E-value: 3.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 729 TVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFdasQIIKA-----RSPQTPII 803
Cdd:cd17562    2 KILAVDDSASIRQMVSFTLRGAGYEVVEAADGRDALSKAQSKKFDLIITDQNMPNMDGI---ELIKElrklpAYKFTPIL 78


                 ....*..
gi 942463857 804 ALSGESG 810
Cdd:cd17562   79 MLTTESS 85
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 729-839 3.43e-12

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 66.13  E-value: 3.43e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 729 TVLIVDDK-EVQRTLVQMyLSRLGVNSL-QAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIkARSPQTPIIALS 806
Cdd:COG3707    5 RVLVVDDEpLRRADLREG-LREAGYEVVaEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQI-SEERPAPVILLT 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 942463857 807 GESGQRELEMINQL-MDGRLEKPTSLNALQHVLD 839
Cdd:COG3707   83 AYSDPELIERALEAgVSAYLVKPLDPEDLLPALE 116
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 728-807 4.46e-12

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 63.58  E-value: 4.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 728 PTVLIVDDKEVQRTLVQMYLSRLGVNSL-QAKNGENAVELFRTHKVDLILMDVQMP-IMNGFDASQIIKARSPqTPIIAL 805
Cdd:cd17534    1 KKILIVEDEAIIALDLKEILESLGYEVVgIADSGEEAIELAEENKPDLILMDINLKgDMDGIEAAREIREKFD-IPVIFL 79


                 ..
gi 942463857 806 SG 807
Cdd:cd17534   80 TA 81
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 728-814 5.86e-12

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 63.23  E-value: 5.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 728 PTVLIVDDKEVQRTLVQMYLSRLGVNSLQA-KNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSP--QTPIIA 804
Cdd:cd17551    1 MRILIVDDNPTNLLLLEALLRSAGYLEVVSfTDPREALAWCRENPPDLILLDYMMPGMDGLEFIRRLRALPGleDVPIVM 80

                         90
                 ....*....|
gi 942463857 805 LSGeSGQREL 814
Cdd:cd17551   81 ITA-DTDREV 89
REC_ETR-like cd19933
phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and ...
 730-838 7.25e-12

phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and similar proteins; Plant ethylene receptors contain N-terminal transmembrane domains that contain an ethylene binding site and also serve in localization of the receptor to the endoplasmic reticulum or the Golgi apparatus and a C-terminal histidine kinase (HK)-like domain. There are five ethylene receptors (ETR1, ERS1, ETR2, ERS2, and EIN4) in Arabidopsis thaliana. ETR1, ETR2, and EIN4 also contain REC domains C-terminal to the HK domain. ETR1 and ERS1 belong to subfamily 1, and have functional HK domains while ETR2, ERS2, and EIN4 belong to subfamily 2, and lack the necessary residues for HK activity and may function as serine/threonine kinases. The plant hormone ethylene plays an important role in plant growth and development. It regulates seed germination, seedling growth, leaf and petal abscission, fruit ripening, organ senescence, and pathogen responses. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381160 [Multi-domain]  Cd Length: 117  Bit Score: 62.80  E-value: 7.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELF--RTHKVDLILMDVQMPIMNGFD-ASQIIKARSPQTP--IIA 804
Cdd:cd19933    3 VLLVDDNAVNRMVTKGLLEKLGCEVTTVSSGEECLNLLasAEHSFQLVLLDLCMPEMDGFEvALRIRKLFGRRERplIVA 82

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 942463857 805 LSGESGQRELEMINQL-MDGRLEKPTSLNALQHVL 838
Cdd:cd19933   83 LTANTDDSTREKCLSLgMNGVITKPVSLHALGDEL 117
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 582-683 1.15e-11

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 62.00  E-value: 1.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857  582 VIFNLIRNAIYYfdSYPDSQIEISTKIDSyENVLIFRDTGPGIDEAIAHKIFDDFFSYQKSGGSGLGL--GYCQRVMRSF 659
Cdd:pfam02518   9 VLSNLLDNALKH--AAKAGEITVTLSEGG-ELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGGTGLglSIVRKLVELL 85

                          90       100
                  ....*....|....*....|....
gi 942463857  660 GGRVECHSKLGEFTEFHLYFPVVP 683
Cdd:pfam02518  86 GGTITVESEPGGGTTVTLTLPLAQ 109
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
730-806 1.68e-11

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 66.71  E-value: 1.68e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSR------LGVnslqAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPqTPII 803
Cdd:PRK00742   6 VLVVDDSAFMRRLISEILNSdpdievVGT----APDGLEAREKIKKLNPDVITLDVEMPVMDGLDALEKIMRLRP-TPVV 80


                 ...
gi 942463857 804 ALS 806
Cdd:PRK00742  81 MVS 83
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
439-637 1.80e-11

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 66.53  E-value: 1.80e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 439 ISALQTLLTRVQSTIeadrriRQSRALANSIAHEMRNPLAQVQLHFEVL-KQHIDNQAPAkqilldiengqaaIQRGRQL 517
Cdd:PRK10755 120 TSALNQLVSRLTSTL------DQERLFTADVAHELRTPLAGIRLHLELLeKQHHIDVAPL-------------IARLDQM 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 518 IDII-----LREVSD--SSPEHGPVTMtsIHKAVDQAVSHYGFENEKIIERIRLPQHA-DFVVKLNETLFNFVIFNLIRN 589
Cdd:PRK10755 181 MHTVeqllqLARAGQsfSSGHYQTVKL--LEDVILPSQDELSEMLEQRQQTLLLPESAaDITVQGDATLLRLLLRNLVEN 258

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 942463857 590 AIYYfdSYPDSQIEISTKIDSYENVLIFRDTGPGIDEAIAHKIFDDFF 637
Cdd:PRK10755 259 AHRY--SPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFV 304
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 465-682 4.91e-11

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 65.91  E-value: 4.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 465 LANSIAHEMRNPLAQVQLHFEVLKQHIDNQAPAKQILLDiENGQA--------------AIQRGRQLIDIILREVsdssp 530
Cdd:COG5805  290 LAAGIAHEIRNPLTSIKGFLQLLQPGIEDKEEYFDIMLS-ELDRIesiiseflalakpqAVNKEKENINELIQDV----- 363

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 531 ehgpvTMTSIHKAVDQAVSHYGFENEKIIErirlpqhadfvVKLNETLFNFVIFNLIRNAIyyfDSYPD-SQIEISTKID 609
Cdd:COG5805  364 -----VTLLETEAILHNIQIRLELLDEDPF-----------IYCDENQIKQVFINLIKNAI---EAMPNgGTITIHTEEE 424

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 942463857 610 SYENVLIFRDTGPGIDEAIAHKIFDDFFSyQKSGGSGLGLGYCQRVMRSFGGRVECHSKLGEFTEFHLYFPVV 682
Cdd:COG5805  425 DNSVIIRVIDEGIGIPEERLKKLGEPFFT-TKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPLS 496
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 731-806 5.43e-11

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 60.36  E-value: 5.43e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 942463857 731 LIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIK--ARSPQTPIIALS 806
Cdd:cd19937    1 LVVDDEEDIVELLKYNLEKEGYEVVTAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILRsdPKTSSIPIIMLT 78
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 730-820 5.85e-11

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 60.64  E-value: 5.85e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRL-GVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKArSPQT---PIIAL 805
Cdd:cd17552    4 ILVIDDEEDIREVVQACLEKLaGWEVLTASSGQEGLEKAATEQPDAILLDVMMPDMDGLATLKKLQA-NPETqsiPVILL 82

                         90
                 ....*....|....*
gi 942463857 806 SGESGQRELEMINQL 820
Cdd:cd17552   83 TAKAQPSDRQRFASL 97
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 730-807 9.49e-11

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 59.84  E-value: 9.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHK-VDLILMDVQMPIMNGFDASQIIKARSP--QTPIIALS 806
Cdd:cd17544    3 VLVVDDSATSRNHLRALLRRHNFQVLEAANGQEALEVLEQHPdIKLVITDYNMPEMDGFELVREIRKKYSrdQLAIIGIS 82


                 .
gi 942463857 807 G 807
Cdd:cd17544   83 A 83
PRK13557 PRK13557
histidine kinase; Provisional
 619-819 1.00e-10

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 65.08  E-value: 1.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 619 DTGPGIDEAIAHKIFDDFFSYQ---KSGGSGLGLGYcqRVMRSFGGRVECHSKLGEFTEFHLYFPVVpnapkadalrtpy 695
Cdd:PRK13557 331 DTGSGMPPEILARVMDPFFTTKeegKGTGLGLSMVY--GFAKQSGGAVRIYSEVGEGTTVRLYFPAS------------- 395

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 696 fndwkhnqtttqDKTCADTQPTSSRESESHLAPTVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTH-KVDL 774
Cdd:PRK13557 396 ------------DQAENPEQEPKARAIDRGGTETILIVDDRPDVAELARMILEDFGYRTLVASNGREALEILDSHpEVDL 463

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 942463857 775 ILMDVQMP-IMNGFDASQIIKARSPQTPIIALSG---ESGQR------ELEMINQ 819
Cdd:PRK13557 464 LFTDLIMPgGMNGVMLAREARRRQPKIKVLLTTGyaeASIERtdaggsEFDILNK 518
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 728-809 1.11e-10

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 59.32  E-value: 1.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 728 PTVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSpQTPIIALSG 807
Cdd:cd17619    1 PHILIVEDEPVTRATLKSYFEQEGYDVSEAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELREQS-EVGIILVTG 79


                 ..
gi 942463857 808 ES 809
Cdd:cd17619   80 RD 81
PRK10337 PRK10337
sensor protein QseC; Provisional
 439-630 2.01e-10

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 63.90  E-value: 2.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 439 ISALQTLLTRVQSTIEADRRIrQSRAlansiAHEMRNPLAQVQLHFEVLKQHIDNQAPAKQILLDIENGqaaIQRGRQLI 518
Cdd:PRK10337 220 VEALNQLFARTHAMMVRERRF-TSDA-----AHELRSPLAALKVQTEVAQLSDDDPQARKKALLQLHAG---IDRATRLV 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 519 DIIL---REVSDSSPEHgpVTMTSIHKAVDQAV-SHYGFENEKIIErIRLPQHADFVVKL-NETLFNFVIFNLIRNAIYY 593
Cdd:PRK10337 291 DQLLtlsRLDSLDNLQD--VAEIPLEDLLQSAVmDIYHTAQQAGID-VRLTLNAHPVIRTgQPLLLSLLVRNLLDNAIRY 367

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 942463857 594 fdSYPDSQIEISTKidsyENVLIFRDTGPGI-DEAIAH 630
Cdd:PRK10337 368 --SPQGSVVDVTLN----ARNFTVRDNGPGVtPEALAR 399
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 730-814 2.16e-10

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 58.89  E-value: 2.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGV-NSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQ--TPIIALS 806
Cdd:cd19923    3 VLVVDDFSTMRRIIKNLLKELGFnNVEEAEDGVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIRADGALshLPVLMVT 82


                 ....*...
gi 942463857 807 GESGQREL 814
Cdd:cd19923   83 AEAKKENV 90
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 730-836 2.17e-10

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 58.72  E-value: 2.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSGES 809
Cdd:cd17553    3 ILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYG 82

                         90       100
                 ....*....|....*....|....*..
gi 942463857 810 gqrELEMINQLMDgrlekptsLNALQH 836
Cdd:cd17553   83 ---ELDMIQESKE--------LGALTH 98
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
712-838 2.26e-10

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 64.61  E-value: 2.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 712 ADTQPTSSRESESHLAPTVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQ 791
Cdd:PRK10841 786 ANALPSTDKAVSDNDDMMILVVDDHPINRRLLADQLGSLGYQCKTANDGVDALNVLSKNHIDIVLTDVNMPNMDGYRLTQ 865

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 942463857 792 IIKARSPQTPII-----ALSgESGQRELEminQLMDGRLEKPTSLNALQHVL 838
Cdd:PRK10841 866 RLRQLGLTLPVIgvtanALA-EEKQRCLE---AGMDSCLSKPVTLDVLKQTL 913
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 730-802 4.60e-10

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 57.16  E-value: 4.60e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPI 802
Cdd:cd19926    1 VLVVDDEPDIRELLEITLGRMGLDVRSARNVKEARELLASEPYDLCLTDMRLPDGSGLELVQHIQQRLPQTPV 73
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
459-835 6.88e-10

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 63.21  E-value: 6.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857  459 IRQSRALAnSIAHEMRNPLAQVQLHFEVLK-QHIDNQAPAKQILLDIENGQAAIQRGRQLIDIILREVSDSSPEHGPVTM 537
Cdd:PRK09959  710 VAKSQFLA-TMSHEIRTPISSIMGFLELLSgSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDI 788

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857  538 TSIhkaVDQAVSHYG-FENEKIIE---RIRLPQHadFVVKLNETLFNFVIFNLIRNAIYYfdsYPDSQIEISTK---IDS 610
Cdd:PRK09959  789 PTL---VQNTCHSFGaIAASKSIAlscSSTFPDH--YLVKIDPQAFKQVLSNLLSNALKF---TTEGAVKITTSlghIDD 860

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857  611 YENV--LIFRDTGPGIDEAIAHKIFDDFFSY---QKSGGSGLGLGYCQRVMRSFGGRVECHSKLGEFTEFHLYFPVvpna 685
Cdd:PRK09959  861 NHAVikMTIMDSGSGLSQEEQQQLFKRYSQTsagRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPV---- 936

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857  686 pkadalrtpyfndwKHNQTTTQDKTCADtQPTSSRESEShlaptVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVE 765
Cdd:PRK09959  937 --------------EISQQVATVEAKAE-QPITLPEKLS-----ILIADDHPTNRLLLKRQLNLLGYDVDEATDGVQALH 996

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 942463857  766 LFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSGESGQRELEM-INQLMDGRLEKPTSLNALQ 835
Cdd:PRK09959  997 KVSMQHYDLLITDVNMPNMDGFELTRKLREQNSSLPIWGLTANAQANEREKgLSCGMNLCLFKPLTLDVLK 1067
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 730-803 7.40e-10

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 57.21  E-value: 7.40e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPII 803
Cdd:cd17572    1 VLLVEDSPSLAALYQEYLSDEGYKVTHVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVI 74
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
448-838 7.55e-10

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 62.77  E-value: 7.55e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 448 RVQSTIEA-DRRIRQSR------ALANSIAHEMRNPLAQVQLHFEVLKQHIDNQAPAKQILLDIENgqaAIQRGRQLIDI 520
Cdd:PRK13837 429 RLETERDAlERRLEHARrleavgTLASGIAHNFNNILGAILGYAEMALNKLARHSRAARYIDEIIS---AGARARLIIDQ 505

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 521 ILrevSDSSPEHGPVTMTSIHKAVDQAVShygfenekiIERIRLPQHADF---------VVKLNETLFNFVIFNLIRNAI 591
Cdd:PRK13837 506 IL---AFGRKGERNTKPFDLSELVTEIAP---------LLRVSLPPGVELdfdqdqepaVVEGNPAELQQVLMNLCSNAA 573

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 592 YYFDsyPDSQIEIS--------TKIDSYEN-------VLIFRDTGPGIDEAIAHKIFDDFFSyQKSGGSGLGLGYCQRVM 656
Cdd:PRK13837 574 QAMD--GAGRVDISlsraklraPKVLSHGVlppgryvLLRVSDTGAGIDEAVLPHIFEPFFT-TRAGGTGLGLATVHGIV 650

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 657 RSFGGRVECHSKLGEFTEFHLYFPVVPNAPKAdalrtpyfndwkhnqttTQDKTCADTQPTSSREseshlapTVLIVDDk 736
Cdd:PRK13837 651 SAHAGYIDVQSTVGRGTRFDVYLPPSSKVPVA-----------------PQAFFGPGPLPRGRGE-------TVLLVEP- 705

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 737 evQRTLVQMY---LSRLGVNSLQAKNGENAVELFRT--HKVDLILmdVQMPIMNGFDASQIIKARSPQTPIIAL---SGE 808
Cdd:PRK13837 706 --DDATLERYeekLAALGYEPVGFSTLAAAIAWISKgpERFDLVL--VDDRLLDEEQAAAALHAAAPTLPIILGgnsKTM 781

                        410       420       430
                 ....*....|....*....|....*....|
gi 942463857 809 SGQRELEMINQLMdgrLEKPTSLNALQHVL 838
Cdd:PRK13837 782 ALSPDLLASVAEI---LAKPISSRTLAYAL 808
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 729-806 9.46e-10

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 56.98  E-value: 9.46e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 942463857 729 TVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALS 806
Cdd:cd17615    1 RVLVVDDEPNITELLSMALRYEGWDVETAADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVLFLT 78
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 730-806 1.09e-09

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 56.54  E-value: 1.09e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSpQTPIIALS 806
Cdd:cd17623    1 ILLIDDDRELTELLTEYLEMEGFNVRAAHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKTS-QVPVLMLT 76
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
408-683 1.33e-09

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 61.52  E-value: 1.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 408 LVMPLFGQGksvTHLLVSS---HKSNDQMfsneeISALQTLLTRVQSTiEADRRIRQSRALAN------SIAHEMRNPLA 478
Cdd:PRK11360 336 ISFPGRDRT---IELSVSTsllHNTHGEM-----IGALVIFSDLTERK-RLQRRVARQERLAAlgelvaGVAHEIRNPLT 406

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 479 QVQLHFEVLKQHIDNQAPakqilldiengqaaiqrgRQLIDIILREVsdsspehgpvtmTSIHKAVDQAV-----SHYGF 553
Cdd:PRK11360 407 AIRGYVQIWRQQTSDPPS------------------QEYLSVVLREV------------DRLNKVIDQLLefsrpRESQW 456

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 554 E----NEKIIERIRLPQHA------DFVVKLNETL---------FNFVIFNLIRNAIYYFDSypDSQIEISTKIDSYENV 614
Cdd:PRK11360 457 QpvslNALVEEVLQLFQTAgvqarvDFETELDNELppiwadpelLKQVLLNILINAVQAISA--RGKIRIRTWQYSDGQV 534

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 615 LI-FRDTGPGIDEAIAHKIFDDFFSyQKSGGSGLGLGYCQRVMRSFGGRVECHSKLGEFTEFHLYFPVVP 683
Cdd:PRK11360 535 AVsIEDNGCGIDPELLKKIFDPFFT-TKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINP 603
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 730-810 1.62e-09

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 56.23  E-value: 1.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELF---------RTHKVDLILMDVQMPIMNGFDASQIIKA--RSP 798
Cdd:cd19924    1 ILVVDDSPTARKQLRDLLKNLGFEIAEAVDGEEALNKLenlakegndLSKELDLIITDIEMPKMDGYELTFELRDdpRLA 80

                         90
                 ....*....|..
gi 942463857 799 QTPIIALSGESG 810
Cdd:cd19924   81 NIPVILNSSLSG 92
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 729-846 1.75e-09

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 56.66  E-value: 1.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 729 TVLIVDDKEVQRTLVQMYLSRLGV-NSLQ-AKNGENAVE-LFRT------HKVDLILMDVQMPIMNGFDASQIIKArSPQ 799
Cdd:cd17557    1 TILLVEDNPGDAELIQEAFKEAGVpNELHvVRDGEEALDfLRGEgeyadaPRPDLILLDLNMPRMDGFEVLREIKA-DPD 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 942463857 800 T---PIIALSGESGQRELEMINQL-MDGRLEKPTSLNALQHVLDNwLEKDW 846
Cdd:cd17557   80 LrriPVVVLTTSDAEEDIERAYELgANSYIVKPVDFEEFVEAIRS-LGEYW 129
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 730-807 2.16e-09

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 55.43  E-value: 2.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTH-KVDLILMDVQMP-IMNGFDASQIIKARSPQTPIIALSG 807
Cdd:cd18161    1 VLVVEDDPDVRRLTAEVLEDLGYTVLEAASGDEALDLLESGpDIDLLVTDVIMPgGMNGSQLAEEARRRRPDLKVLLTSG 80
PRK09483 PRK09483
response regulator; Provisional
 729-806 2.61e-09

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 58.19  E-value: 2.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 729 TVLIVDDKEVQRTLVQMYLSRL-GVNSL-QAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALS 806
Cdd:PRK09483   3 NVLLVDDHELVRAGIRRILEDIkGIKVVgEACCGEDAVKWCRTNAVDVVLMDMNMPGIGGLEATRKILRYTPDVKIIMLT 82
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 728-806 2.71e-09

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 55.72  E-value: 2.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 728 PTVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARS--PQTPIIAL 805
Cdd:cd17618    1 RTILIVEDEPAIREMIAFNLERAGFDVVEAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLKRDEmtRDIPIIML 80


                 .
gi 942463857 806 S 806
Cdd:cd17618   81 T 81
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 582-638 3.23e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 55.16  E-value: 3.23e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 942463857 582 VIFNLIRNAIYYFDSYPDSQIEISTKIDSYENVLIFRDTGPGIDEAIAHKIFDDFFS 638
Cdd:cd16976    4 VLMNLLQNALDAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFT 60
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 730-806 5.63e-09

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 54.70  E-value: 5.63e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALS 806
Cdd:cd17627    1 ILVVDDDRAVRESLRRSLRFEGYEVETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLT 77
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 729-834 6.20e-09

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 54.37  E-value: 6.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 729 TVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSpQTPIIALSGE 808
Cdd:cd17594    1 HVLVVDDDAAMRHLLILYLRERGFDVTAAADGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTIRARS-DVPIIIISGD 79

                         90       100
                 ....*....|....*....|....*...
gi 942463857 809 SGQRELEMINQLM--DGRLEKPTSLNAL 834
Cdd:cd17594   80 RRDEIDRVVGLELgaDDYLAKPFGLREL 107
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
730-803 6.69e-09

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 58.35  E-value: 6.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSR------LGVnslqAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPqTPII 803
Cdd:PRK12555   3 IGIVNDSPLAVEALRRALARdpdhevVWV----ATDGAQAVERCAAQPPDVILMDLEMPRMDGVEATRRIMAERP-CPIL 77
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
730-842 8.37e-09

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 58.89  E-value: 8.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSGES 809
Cdd:PRK10365   8 ILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIMTAYS 87

                         90       100       110
                 ....*....|....*....|....*....|....
gi 942463857 810 G-QRELEMINQLMDGRLEKPTSLNALQHVLDNWL 842
Cdd:PRK10365  88 SvETAVEALKTGALDYLIKPLDFDNLQATLEKAL 121
REC_typeA_ARR cd17581
phosphoacceptor receiver (REC) domain of type A Arabidopsis response regulators (ARRs) and ...
 730-835 9.42e-09

phosphoacceptor receiver (REC) domain of type A Arabidopsis response regulators (ARRs) and similar proteins; Type-A response regulators of Arabidopsis (ARRs) are involved in cytokinin signaling, which involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Type-A ARRs function downstream of and are regulated by type-B ARRs, which are a class of MYB-type transcription factors. As primary cytokinin response genes, type-A ARRs act as redundant negative feedback regulators of cytokinin signaling by inactivating the phosphorelay. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-A ARRs are similar in domain structure to CheY, in that they lack a typical output domain and only contain a stand-alone receiver (REC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381119 [Multi-domain]  Cd Length: 122  Bit Score: 54.29  E-value: 9.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVEL-----------FRTHKVDLILMDVQMPIMNGFDASQIIKARSP 798
Cdd:cd17581    1 VLAVDDSLVDRKVIERLLRISSCRVTAVDSGKRALEFlgledeedssnFNEPKVNMIITDYCMPGMTGYDLLKKVKESSA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 942463857 799 --QTPIIALSGESgqrELEMINQLMDGRLE----KPTSLNALQ 835
Cdd:cd17581   81 lkEIPVVIMSSEN---IPTRISRCLEEGAEdfllKPVKLADVK 120
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 245-684 1.21e-08

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 57.94  E-value: 1.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 245 RFYSVKYLAYMSLNALLVCAILVIPFGAIFIPLTEDNQWLIAIPICALIGITWHVLYKRVSRYASFFVYgnkttpVQQIL 324
Cdd:COG3290    6 LLLLLLLILLILILILLLLLLIILLLILLLVLLLLLFLLFVIILLLLLLILLLILLLLLLLLLAALLLK------LLEEI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 325 ALEEDFKLSIDDAMRRlGSLLQIPEDKLRLVNSNYNETFYEDYLSTSksvlvFDELSEELDYTAPAKRSINALYEKMSSN 404
Cdd:COG3290   80 ARLVEEREAVLESIRE-GVIAVDRDGRITLINDAARRLLGLDAIGRP-----IDEVLAEVLETGERDEEILLNGRVLVVN 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 405 ntalVMPLFGQGKSVTHLLVSSHKSndqmfsneEISALQTLLTRVQSTIEADRRIRqsralansiaHEMRNplaqvQLHf 484
Cdd:COG3290  154 ----RVPIRDDGRVVGAVATFRDRT--------ELERLEEELEGVKELAEALRAQR----------HDFRN-----HLH- 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 485 eVLKQHIDNQAP--AKQILLDI-ENGQAAIQRGRQ-----LIDIILREVSDSSPEHGpVTMTsihkavdqavshygFENE 556
Cdd:COG3290  206 -TISGLLQLGEYdeALEYIDEIsEELQELIDSLLSrignpVLAALLLGKAARARERG-IDLT--------------IDID 269

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 557 KIIERIRLPQHaDFVVklnetlfnfVIFNLIRNAIYYFDSYPDSQIEISTKIDSYENVLIFR--DTGPGIDEAIAHKIFD 634
Cdd:COG3290  270 SDLPDLPLSDT-DLVT---------ILGNLLDNAIEAVEKLPEEERRVELSIRDDGDELVIEveDSGPGIPEELLEKIFE 339

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 942463857 635 DFFS-----------YQksggsglglgyCQRVMRSFGGRVECHSKLGEFTEFHLYFPVVPN 684
Cdd:COG3290  340 RGFStklgegrglglAL-----------VKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 728-807 1.39e-08

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 53.60  E-value: 1.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 728 PTVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSG 807
Cdd:cd17563    1 KSLLLVDDDEVFAERLARALERRGFEVETAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVVLTG 80
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
435-637 1.40e-08

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 58.11  E-value: 1.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 435 SNEEISALQTLLTRVQSTIEADRRIRqsRALANSIAHEMRNPLAQVQLHFEVLKQHIDNQAPAKQILLdiengQAAIQRG 514
Cdd:PRK10549 215 SRDELGRLAQDFNQLASTLEKNEQMR--RDFMADISHELRTPLAVLRGELEAIQDGVRKFTPESVASL-----QAEVGTL 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 515 RQLIDIiLREVSDSspEHGPV----TMTSIHKAVDQAVSHYG--FENEKIIERIRLPQHADFVV---KLNEtLFNfvifN 585
Cdd:PRK10549 288 TKLVDD-LHQLSLS--DEGALayrkTPVDLVPLLEVAGGAFRerFASRGLTLQLSLPDSATVFGdpdRLMQ-LFN----N 359

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 942463857 586 LIRNAIYYFDSypDSQIEISTKIDSYENVLIFRDTGPGIDEAIAHKIFDDFF 637
Cdd:PRK10549 360 LLENSLRYTDS--GGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFY 409
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 730-810 1.47e-08

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 53.57  E-value: 1.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSGES 809
Cdd:cd17616    1 VLLIEDDSATAQSIELMLKSEGFNVYTTDLGEEGLDLGKLYDYDIILLDLNLPDMSGYEVLRTLRLAKVKTPILILSGLA 80


                 .
gi 942463857 810 G 810
Cdd:cd17616   81 D 81
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 730-803 1.51e-08

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 53.70  E-value: 1.51e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSL--QAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARsPQTPII 803
Cdd:cd17532    1 ALIVDDEPLAREELRYLLEEHPDIEIvgEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLSKL-AKPPLI 75
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 730-803 1.83e-08

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 53.43  E-value: 1.83e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 942463857 730 VLIVDDKEVQR-TLVQMYLSRLGVNSL-QAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPII 803
Cdd:cd19930    1 VLIAEDQEMVRgALAALLELEDDLEVVaQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREELPDTKVL 76
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 730-813 2.07e-08

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 53.10  E-value: 2.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARS--PQTPIIALSG 807
Cdd:cd17598    1 ILIVEDSPTQAEQLKHILEEQGYKVQVARNGREALAMLAEHRPTLVISDIVMPEMDGYELCRKIKSDPdlKDIPVILLTT 80


                 ....*.
gi 942463857 808 ESGQRE 813
Cdd:cd17598   81 LSDPRD 86
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 730-806 2.65e-08

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 52.81  E-value: 2.65e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSpQTPIIALS 806
Cdd:cd17614    1 ILVVDDEKPISDILKFNLTKEGYEVVTAYDGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTS-NVPIIMLT 76
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 729-841 3.13e-08

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 52.63  E-value: 3.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 729 TVLIVDDKEVQRTLVQMYLSRLG--VNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALS 806
Cdd:cd19925    2 NVLIVEDDPMVAEIHRAYVEQVPgfTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVVT 81

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 942463857 807 GEsgqRELEMINQLMDG----RLEKPTSLNALQHVLDNW 841
Cdd:cd19925   82 AA---NDVETVREALRLgvvdYLIKPFTFERLRQRLERY 117
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 728-809 5.29e-08

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 51.89  E-value: 5.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 728 PTVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSG 807
Cdd:cd19919    1 KTVWIVDDDSSIRWVLERALAGAGLTVTSFENAQEALAALASSQPDVLISDIRMPGMDGLALLAQIKQRHPDLPVIIMTA 80


                 ..
gi 942463857 808 ES 809
Cdd:cd19919   81 HS 82
pleD PRK09581
response regulator PleD; Reviewed
 729-809 5.49e-08

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 56.06  E-value: 5.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 729 TVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKArSPQT---PII-- 803
Cdd:PRK09581   4 RILVVDDIPANVKLLEAKLLAEYYTVLTASSGAEAIAICEREQPDIILLDVMMPGMDGFEVCRRLKS-DPATthiPVVmv 82


                 ....*..
gi 942463857 804 -ALSGES 809
Cdd:PRK09581  83 tALDDPE 89
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
 730-809 5.62e-08

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 51.35  E-value: 5.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGvnsLQAKNGENAVELFR---THKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALS 806
Cdd:cd19928    1 ILVADDDRAIRTVLTQALGRAG---YEVRTTGNAATLWRwveEGEGDLVITDVVMPDENGLDLIPRIKKARPDLPIIVMS 77


                 ...
gi 942463857 807 GES 809
Cdd:cd19928   78 AQN 80
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 731-834 6.76e-08

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 51.45  E-value: 6.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 731 LIV-DDKEVQRTLVQMyLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSGES 809
Cdd:cd17625    1 LVVeDEKDLSEAITKH-LKKEGYTVDVCFDGEEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLREEGIETPVLLLTALD 79

                         90       100
                 ....*....|....*....|....*.
gi 942463857 810 G-QRELEMINQLMDGRLEKPTSLNAL 834
Cdd:cd17625   80 AvEDRVKGLDLGADDYLPKPFSLAEL 105
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 730-787 8.72e-08

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 50.84  E-value: 8.72e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGF 787
Cdd:cd19927    1 ILLVDDDPGIRLAVKDYLEDQGFTVIAASNGLEALDLLNQYIPDLIISDIIMPGVDGY 58
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 730-806 1.09e-07

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 50.52  E-value: 1.09e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSpQTPIIALS 806
Cdd:cd19936    1 IALVDDDRNILTSVSMALEAEGFSVETYTDGASALDGLNARPPDLAILDIKMPRMDGMELLQRLRQKS-TLPVIFLT 76
PRK10610 PRK10610
chemotaxis protein CheY;
731-844 1.35e-07

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 51.13  E-value: 1.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 731 LIVDDKEVQRTLVQMYLSRLGVNSLQ-AKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARS--PQTPIIALSG 807
Cdd:PRK10610   9 LVVDDFSTMRRIVRNLLKELGFNNVEeAEDGVDALNKLQAGGFGFVISDWNMPNMDGLELLKTIRADGamSALPVLMVTA 88

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 942463857 808 ESGQRELEMINQL-MDGRLEKPTSLNALQHVLDNWLEK 844
Cdd:PRK10610  89 EAKKENIIAAAQAgASGYVVKPFTAATLEEKLNKIFEK 126
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 730-830 1.38e-07

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 50.83  E-value: 1.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQtPIIALSGES 809
Cdd:cd19939    2 ILIVEDELELARLTRDYLIKAGLEVSVFTDGQRAVRRIIDEQPSLVVLDIMLPGMDGLTVCREVREHSHV-PILMLTART 80

                         90       100
                 ....*....|....*....|....*..
gi 942463857 810 gqrelEMINQLM------DGRLEKPTS 830
Cdd:cd19939   81 -----EEMDRVLglemgaDDYLCKPFS 102
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 730-806 1.46e-07

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 50.13  E-value: 1.46e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 942463857 730 VLIV-DDKEVQRTLVQMyLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALS 806
Cdd:cd19935    1 ILVVeDEKKLAEYLKKG-LTEEGYAVDVAYDGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAGKQTPVLMLT 77
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 730-809 1.77e-07

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 50.55  E-value: 1.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSpQTPIIALSGES 809
Cdd:cd17626    3 ILVVDDDAALAEMIGIVLRGEGFDPAFCGDGTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQIRAES-GVPIVMLTAKS 81
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 582-680 2.66e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 49.59  E-value: 2.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 582 VIFNLIRNAiyyFDS-----YPDSQIEISTKIDSYENVLIFRDTGPGIDEAIAHKIFDDFFSYQKSGGSGLGLGYCQRVM 656
Cdd:cd16915    4 IVGNLIDNA---LDAlaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGERGIGLALVRQSV 80

                         90       100
                 ....*....|....*....|....
gi 942463857 657 RSFGGRVECHSKLGEFTEFHLYFP 680
Cdd:cd16915   81 ERLGGSITVESEPGGGTTFSIRIP 104
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 730-813 2.79e-07

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 49.47  E-value: 2.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSpQTPIIALSGES 809
Cdd:cd17620    1 ILVIEDEPQIRRFLRTALEAHGYRVFEAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRLREWS-AVPVIVLSARD 79


                 ....
gi 942463857 810 GQRE 813
Cdd:cd17620   80 EESD 83
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 727-806 4.89e-07

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 51.57  E-value: 4.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 727 APTVLIVDDKEVQRTLVQMYLS---RLGVNSlQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPII 803
Cdd:PRK10651   6 PATILLIDDHPMLRTGVKQLISmapDITVVG-EASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLSGRIV 84


                 ...
gi 942463857 804 ALS 806
Cdd:PRK10651  85 VFS 87
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
730-828 5.14e-07

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 51.73  E-value: 5.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRThKVDLILMDVQMPIMNGFDASQIIKARSpQTPIIALSGES 809
Cdd:PRK10955   4 ILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLLDD-SIDLLLLDVMMPKKNGIDTLKELRQTH-QTPVIMLTARG 81

                         90       100
                 ....*....|....*....|..
gi 942463857 810 GqrELEMINQL---MDGRLEKP 828
Cdd:PRK10955  82 S--ELDRVLGLelgADDYLPKP 101
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 730-806 6.55e-07

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 48.91  E-value: 6.55e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSpQTPIIALS 806
Cdd:cd17622    3 ILLVEDDPKLARLIADFLESHGFNVVVEHRGDRALEVIAREKPDAVLLDIMLPGIDGLTLCRDLRPKY-QGPILLLT 78
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 582-680 6.78e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 48.55  E-value: 6.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 582 VIFNLIRNAIYYFDSYPDS--QIEISTKIDSYENVLIF-RDTGPGIDEAIAHKIFDDFFSyQKSGGSGLGLGYCQRVMRS 658
Cdd:cd16920    4 VLINLVRNGIEAMSEGGCErrELTIRTSPADDRAVTISvKDTGPGIAEEVAGQLFDPFYT-TKSEGLGMGLSICRSIIEA 82

                         90       100
                 ....*....|....*....|..
gi 942463857 659 FGGRVECHSKLGEFTEFHLYFP 680
Cdd:cd16920   83 HGGRLSVESPAGGGATFQFTLP 104
PRK10766 PRK10766
two-component system response regulator TorR;
726-807 7.21e-07

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 50.81  E-value: 7.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 726 LAPTVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSpQTPIIAL 805
Cdd:PRK10766   1 MSYHILVVEDEPVTRARLQGYFEQEGYTVSEAASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELRSRS-TVGIILV 79


                 ..
gi 942463857 806 SG 807
Cdd:PRK10766  80 TG 81
PRK10693 PRK10693
two-component system response regulator RssB;
756-806 7.23e-07

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 51.92  E-value: 7.23e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 942463857 756 QAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALS 806
Cdd:PRK10693   2 LAANGVDALELLGGFTPDLIICDLAMPRMNGIEFVEHLRNRGDQTPVLVIS 52
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 730-838 7.31e-07

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 48.78  E-value: 7.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHK--VDLILMDVQMPIMNGFDASQIIKArSPQTPIIALSg 807
Cdd:cd17584    1 VLVVDDDPTCLAILKRMLLRCGYQVTTCTDAEEALSMLRENKdeFDLVITDVHMPDMDGFEFLELIRL-EMDLPVIMMS- 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 942463857 808 eSGQRELEMINQLMDGR---LEKPTSLNAL----QHVL 838
Cdd:cd17584   79 -ADGSTSTVMKGLAHGAcdyLLKPVSIEDLkniwQHVV 115
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 730-844 2.13e-06

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 47.87  E-value: 2.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDD-KEVQRTLVQMyLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSGE 808
Cdd:cd17549    1 VLLVDDdADVREALQQT-LELAGFRVRAFADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELDPDLPVILITGH 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 942463857 809 SgqrELEMINQLM-DGR---LEKPTSLNALQHVLDNWLEK 844
Cdd:cd17549   80 G---DVPMAVEAMrAGAydfLEKPFDPERLLDVVRRALEK 116
PRK10604 PRK10604
sensor protein RstB; Provisional
 465-636 2.42e-06

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 50.76  E-value: 2.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 465 LANSIAHEMRNPLAQVQLHFEVLkqhiDNQAPAKQILLDIENGQAaiqrgRQLIDIILREVSDSSPEHgPVTMTSI---- 540
Cdd:PRK10604 215 LIDGIAHELRTPLVRLRYRLEMS----DNLSAAESQALNRDIGQL-----EALIEELLTYARLDRPQN-ELHLSEPdlpa 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 541 ----HKAVDQAVSHygfenEKIIErIRLPQHADFVVkLNETLFNFVIFNLIRNAIyyfdSYPDSQIEISTKIDSYENVLI 616
Cdd:PRK10604 285 wlstHLADIQAVTP-----EKTVR-LDTPHQGDYGA-LDMRLMERVLDNLLNNAL----RYAHSRVRVSLLLDGNQACLI 353

                        170       180
                 ....*....|....*....|
gi 942463857 617 FRDTGPGIDEAIAHKIFDDF 636
Cdd:PRK10604 354 VEDDGPGIPPEERERVFEPF 373
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 729-857 4.43e-06

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 48.17  E-value: 4.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 729 TVLIVDDKEVQRTLVQMYLSRLGvnsLQAKNGENAVELFRTHKVDL---ILMDVQMPIMNGFDASQIIKARSPQTPIIAL 805
Cdd:COG4566    1 TVYIVDDDEAVRDSLAFLLESAG---LRVETFASAEAFLAALDPDRpgcLLLDVRMPGMSGLELQEELAARGSPLPVIFL 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 942463857 806 SGESgqrELEMINQLMdgR------LEKPTSLNALQHVLDNWLEKDWASNASKEAEGE 857
Cdd:COG4566   78 TGHG---DVPMAVRAM--KagavdfLEKPFDDQALLDAVRRALARDRARRAERARRAE 130
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 730-806 5.25e-06

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 46.32  E-value: 5.25e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 942463857 730 VLIV-DDKEVQRTLVQmYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALS 806
Cdd:cd17624    1 ILLVeDDALLGDGLKT-GLRKAGYAVDWVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLILT 77
ompR PRK09468
osmolarity response regulator; Provisional
 730-816 5.49e-06

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 48.43  E-value: 5.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALS--G 807
Cdd:PRK09468   8 ILVVDDDMRLRALLERYLTEQGFQVRSAANAEQMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQNNPTPIIMLTakG 87

                         90
                 ....*....|.
gi 942463857 808 ESGQR--ELEM 816
Cdd:PRK09468  88 EEVDRivGLEI 98
REC_TPR cd17589
phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...
 730-835 6.85e-06

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.


Pssm-ID: 381123 [Multi-domain]  Cd Length: 115  Bit Score: 45.72  E-value: 6.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDD-KEVQRTLVQMyLSRLGVNSLQ-AKNGENAVELFRTHKVDLILMDVQMPimNGFDASQII------KARSPQTP 801
Cdd:cd17589    1 FLIVDDqPTFRSMLKSM-LRSLGVTRIDtASSGEEALRMCENKTYDIVLCDYNLG--KGKNGQQLLeelrhkKLISPSTV 77

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 942463857 802 IIALSGESGQrelEMINQLM----DGRLEKPTSLNALQ 835
Cdd:cd17589   78 FIMVTGESSR---AMVLSALelepDDYLLKPFTVSELR 112
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 582-680 6.96e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 45.40  E-value: 6.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 582 VIFNLIRNAIYYFDSYPDSQIEISTKIDSYENVLIFRDTGPGIDEAIAHKIFDDFfsyQKSGGSGLGL------GYCQRV 655
Cdd:cd16921    4 VLTNLLGNAIKFRRPRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIF---QRLHSREEYEgtgvglAIVRKI 80

                         90       100
                 ....*....|....*....|....*
gi 942463857 656 MRSFGGRVECHSKLGEFTEFHLYFP 680
Cdd:cd16921   81 IERHGGRIWLESEPGEGTTFYFTLP 105
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 730-829 7.22e-06

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 45.80  E-value: 7.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSL--QAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSG 807
Cdd:cd19931    1 VLLIDDHPLLRKGIKQLIELDPDFTVvgEASSGEEGIELAERLDPDLILLDLNMKGMSGLDTLKALREEGVSARIVILTV 80

                         90       100
                 ....*....|....*....|...
gi 942463857 808 ESGQREL-EMINQLMDGRLEKPT 829
Cdd:cd19931   81 SDAEDDVvTALRAGADGYLLKDM 103
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 730-809 8.47e-06

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 49.10  E-value: 8.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSGES 809
Cdd:PRK10923   6 VWVVDDDSSIRWVLERALAGAGLTCTTFENGNEVLEALASKTPDVLLSDIRMPGMDGLALLKQIKQRHPMLPVIIMTAHS 85
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 730-810 8.52e-06

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 45.05  E-value: 8.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFD------ASQIIKArspqTPII 803
Cdd:cd17602    1 VACVDDRPSIQKMIEYFLEKQGFRVVVIDDPLRALTTLLNSKPDLILIDIDMPDLDGYElcsllrKSSALKD----TPII 76


                 ....*..
gi 942463857 804 ALSGESG 810
Cdd:cd17602   77 MLTGKDG 83
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 578-681 9.07e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 45.11  E-value: 9.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 578 LFNFVIFNLIRNAIYYFDSYpdSQIEISTKIDSYENVLIFRDTGPGIDEAIAHKIFDDFFSYQKSGG-SGLGLGYCQRVM 656
Cdd:cd16943    3 QLNQVLLNLLVNAAQAMEGR--GRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEgTGLGLSLSYRII 80

                         90       100
                 ....*....|....*....|....*
gi 942463857 657 RSFGGRVECHSKLGEFTEFHLYFPV 681
Cdd:cd16943   81 QKHGGTIRVASVPGGGTRFTIILPI 105
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 585-637 9.85e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 45.01  E-value: 9.85e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 942463857 585 NLIRNAIyyfdSYPDSQIEISTKIDSYENVLIFRDTGPGIDEAIAHKIFDDFF 637
Cdd:cd16949    7 NVLRNAL----RYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFY 55
envZ PRK09467
osmolarity sensor protein; Provisional
 454-636 1.01e-05

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 48.75  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 454 EADRRIrqsraLANSIAHEMRNPLAQVQLHFEVLKQhiDNQAPAKQILLDIENGQAAIQrgrQLIDIIlREVSDSSPEhg 533
Cdd:PRK09467 226 EDDRTL-----LMAGVSHDLRTPLTRIRLATEMMSE--EDGYLAESINKDIEECNAIIE---QFIDYL-RTGQEMPME-- 292

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 534 PVTMTSIHKAVDQAVSHYgfenEKIIErirlpqhadfvVKLNETLFNF---------VIFNLIRNAIyyfdSYPDSQIEI 604
Cdd:PRK09467 293 MADLNALLGEVIAAESGY----EREIE-----------TALQPGPIEVpmnpiaikrALANLVVNAA----RYGNGWIKV 353

                        170       180       190
                 ....*....|....*....|....*....|..
gi 942463857 605 STKIDSYENVLIFRDTGPGIDEAIAHKIFDDF 636
Cdd:PRK09467 354 SSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPF 385
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 729-807 2.09e-05

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 44.03  E-value: 2.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 729 TVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHK-VDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSG 807
Cdd:cd18160    1 TILLADDEPSVRKFIVTTLKKAGYAVTEAESGAEALEKLQQGKdIDIVVTDIVMPEMDGIELAREARKIDPDVKILFISG 80
PRK15115 PRK15115
response regulator GlrR; Provisional
 724-843 2.68e-05

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 47.52  E-value: 2.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 724 SHLAPTVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPII 803
Cdd:PRK15115   2 SRKPAHLLLVDDDPGLLKLLGMRLTSEGYSVVTAESGQEALRVLNREKVDLVISDLRMDEMDGMQLFAEIQKVQPGMPVI 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 942463857 804 ALSGE-SGQRELEMINQLMDGRLEKPTSLNALQHVLDNWLE 843
Cdd:PRK15115  82 ILTAHgSIPDAVAATQQGVFSFLTKPVDRDALYKAIDDALE 122
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 581-680 3.61e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 43.43  E-value: 3.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 581 FVIFNLIRNAIYYFDSypDSQIEISTKIDSYENVLIFRDTGPGIDEAIAHKIFDDFFSYQ---KSGGSGLGLGY-CQRVM 656
Cdd:cd16948    8 FIIGQIVSNALKYSKQ--GGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGEngrNFQESTGMGLYlVKKLC 85

                         90       100
                 ....*....|....*....|....
gi 942463857 657 RSFGGRVECHSKLGEFTEFHLYFP 680
Cdd:cd16948   86 DKLGHKIDVESEVGEGTTFTITFP 109
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
 730-834 4.69e-05

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 43.19  E-value: 4.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSGE- 808
Cdd:cd17573    1 ILLIEDDSTLGKEISKGLNEKGYQADVAESLKDGEYYIDIRNYDLVLVSDKLPDGNGLSIVSRIKEKHPSIVVIVLSDNp 80

                         90       100
                 ....*....|....*....|....*.
gi 942463857 809 SGQRELEMINQLMDGRLEKPTSLNAL 834
Cdd:cd17573   81 KTEQEIEAFKEGADDYIAKPFDFKVL 106
PRK09303 PRK09303
histidine kinase;
431-681 5.54e-05

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 46.48  E-value: 5.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 431 DQMFS----NEeisalqTLLTRVQStieadrrirQSRALAnSIAHEMRNPLAQVQLHFEVLKQhidnqapaKQILLDIEN 506
Cdd:PRK09303 132 DELFVlrqeNE------TLLEQLKF---------KDRVLA-MLAHDLRTPLTAASLALETLEL--------GQIDEDTEL 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 507 GQAAIQR-----GRQLIDI------ILrEVSDSSPE-----HGPVTMTSIHKAV-DQAVSHYGFENEKIIERI--RLPQ- 566
Cdd:PRK09303 188 KPALIEQlqdqaRRQLEEIerlitdLL-EVGRTRWEalrfnPQKLDLGSLCQEViLELEKRWLAKSLEIQTDIpsDLPSv 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 567 HADfvvklnETLFNFVIFNLIRNAIYYfdSYPDSQIEI------STKIDsyenVLIfRDTGPGIDEAIAHKIFDDFFSYQ 640
Cdd:PRK09303 267 YAD------QERIRQVLLNLLDNAIKY--TPEGGTITLsmlhrtTQKVQ----VSI-CDTGPGIPEEEQERIFEDRVRLP 333

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 942463857 641 KSGGSG---LGLGYCQRVMRSFGGRVECHSKLGEFTEFHLYFPV 681
Cdd:PRK09303 334 RDEGTEgygIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLPV 377
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 728-811 5.76e-05

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 45.34  E-value: 5.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 728 PTVLIVDDKE-VQRTLVQMyLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALS 806
Cdd:PRK11083   4 PTILLVEDEQaIADTLVYA-LQSEGFTVEWFERGLPALDKLRQQPPDLVILDVGLPDISGFELCRQLLAFHPALPVIFLT 82


                 ....*
gi 942463857 807 GESGQ 811
Cdd:PRK11083  83 ARSDE 87
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 463-519 6.98e-05

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 41.43  E-value: 6.98e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 942463857 463 RALANSIAHEMRNPLAQVQLHFEVLKQHIDNQAPAKQILLDIengQAAIQRGRQLID 519
Cdd:cd00082    5 GEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERI---REEAERLLRLIN 58
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 582-681 8.01e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 42.48  E-value: 8.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 582 VIFNLIRNAIYYfdsYPDSQIEISTKIDSYEN---VLIF--RDTGPGIDEAIAHKIFDDFFsyQKSGGSGLG-------L 649
Cdd:cd16922    4 ILLNLLGNAIKF---TEEGEVTLRVSLEEEEEdgvQLRFsvEDTGIGIPEEQQARLFEPFS--QADSSTTRKyggtglgL 78

                         90       100       110
                 ....*....|....*....|....*....|..
gi 942463857 650 GYCQRVMRSFGGRVECHSKLGEFTEFHLYFPV 681
Cdd:cd16922   79 AISKKLVELMGGDISVESEPGQGSTFTFTLPL 110
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 438-843 8.78e-05

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 46.44  E-value: 8.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 438 EISALqtLLTRVQSTIEADRRIRQSRALANSIAHEMRNPLAQVQLHFEVLKqhiDNQAPAKQIlldiENGQAAIQRGRQL 517
Cdd:PRK11466 422 ELQEL--VIEHRQARAEAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLA---DNPALNAQR----DDLRAITDSGESL 492

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 518 IdIILREVSD-SSPEHGPVTMtsihkavdqAVSHYGFENEKIIERI------RLPQH-----ADFVVKLNETL------F 579
Cdd:PRK11466 493 L-TILNDILDySAIEAGGKNV---------SVSDEPFEPRPLLESTlqlmsgRVKGRpirlaTDIADDLPTALmgdprrI 562

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 580 NFVIFNLIRNAIYYFDsypDSQIEISTKIDSYENVLIFRDTGPGIDEAIAHKIFDDFFSYQ-KSGGSGLGLGYCQRVMRS 658
Cdd:PRK11466 563 RQVITNLLSNALRFTD---EGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSgKRGGTGLGLTISSRLAQA 639

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 659 FGGRVECHSKLGEFTEFHLYFPV-VPNAPKADALRTPyfndWKHNQTTtqdktcadtqptssreseshlapTVLIVDDKE 737
Cdd:PRK11466 640 MGGELSATSTPEVGSCFCLRLPLrVATAPVPKTVNQA----VRLDGLR-----------------------LLLIEDNPL 692

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 738 VQRTLVQMyLSRLGVNSLQAKNGENAVELF-RTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSG---ESGQRe 813
Cdd:PRK11466 693 TQRITAEM-LNTSGAQVVAVGNAAQALETLqNSEPFAAALVDFDLPDYDGITLARQLAQQYPSLVLIGFSAhviDETLR- 770

                        410       420       430
                 ....*....|....*....|....*....|
gi 942463857 814 lEMINQLMDGRLEKPTSLNALQHVLDNWLE 843
Cdd:PRK11466 771 -QRTSSLFRGIIPKPVPREVLGQLLAHYLQ 799
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
 728-807 9.67e-05

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 43.12  E-value: 9.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 728 PTVLIVDDkEVQrtlVQMYLSRL---GVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIA 804
Cdd:cd17596    1 PTILVVDD-EVR---SLEALRRTleeDFDVLTAASAEEALAILEEEWVQVILCDQRMPGTTGVEFLKEVRERWPEVVRII 76


                 ...
gi 942463857 805 LSG 807
Cdd:cd17596   77 ISG 79
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 730-787 1.44e-04

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 41.83  E-value: 1.44e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 942463857 730 VLIVDDKEVQRTLVQMYLSR------LGVnslqAKNGENAVELFRTHKVDLILMDVQMPIMNGF 787
Cdd:cd17561    4 VLIADDNREFVQLLEEYLNSqpdmevVGV----AHNGQEALELIEEKEPDVLLLDIIMPHLDGI 63
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 582-680 1.52e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 42.00  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 582 VIFNLIRNAIYYFDSyPDSQIEISTKIDSYENVLIFR----------DTGPGIDEAIAHKIFDDFFSyQKSGGSGLGLGY 651
Cdd:cd16918    4 VFLNLVRNAAQALAG-SGGEIILRTRTQRQVTLGHPRhrlalrvsviDNGPGIPPDLQDTIFYPMVS-GRENGTGLGLAI 81

                         90       100
                 ....*....|....*....|....*....
gi 942463857 652 CQRVMRSFGGRVECHSKLGEfTEFHLYFP 680
Cdd:cd16918   82 AQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
436-637 1.63e-04

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 44.92  E-value: 1.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 436 NEEISALQTLLTRVQStieadrrirqsraLANSIAHEMRNPLAQVQLHFEVLK---------QHIDNQApakqilldien 506
Cdd:PRK09470 230 NQMVTALERMMTSQQR-------------LLSDISHELRTPLTRLQLATALLRrrqgeskelERIETEA----------- 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 507 gqaaiQRGRQLIDIIL---REVSDSSPEHGPVTMTSIHKAV-DQAvshyGFENEKIIERIRLPQHAD-FVVKLNETLFNF 581
Cdd:PRK09470 286 -----QRLDSMINDLLvlsRNQQKNHLERETFKANSLWSEVlEDA----KFEAEQMGKSLTVSAPPGpWPINGNPNALAS 356

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 942463857 582 VIFNLIRNAIYYfdsyPDSQIEISTKIDSYENVLIFRDTGPGIDEAIAHKIFDDFF 637
Cdd:PRK09470 357 ALENIVRNALRY----SHTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFY 408
PRK15369 PRK15369
two component system response regulator;
730-840 1.66e-04

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 43.91  E-value: 1.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQ----RTLVQMYlSRLGVNSlQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIAL 805
Cdd:PRK15369   6 ILLVDDHELIingiKNMLAPY-PRYKIVG-QVDNGLEVYNACRQLEPDIVILDLGLPGMNGLDVIPQLHQRWPAMNILVL 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 942463857 806 SGESgqRELEMINQLMDGRL-------EKPTSLNALQHVLDN 840
Cdd:PRK15369  84 TARQ--EEHMASRTLAAGALgyvlkksPQQILLAAIQTVAVG 123
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 463-522 1.67e-04

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 40.24  E-value: 1.67e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857   463 RALANSIAHEMRNPLAQVQLHFEVLKQHIDNqAPAKQILLDIengQAAIQRGRQLIDIIL 522
Cdd:smart00388   3 REFLANLSHELRTPLTAIRGYLELLLDTELS-EEQREYLETI---LREAERLLRLINDLL 58
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 460-522 1.84e-04

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 40.27  E-value: 1.84e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 942463857  460 RQSRALANsIAHEMRNPLAQVQLHFEVLKQHIDNQAPAKQilldIENGQAAIQRGRQLIDIIL 522
Cdd:pfam00512   1 AKSEFLAN-LSHELRTPLTAIRGYLELLRDEKLDEEQREY----LETILRSAERLLRLINDLL 58
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 730-803 2.09e-04

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 41.84  E-value: 2.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLgvnsLQAKNGENAVELF-------------RTHKVDLILMDVQMPIMNGFDASQIIKAR 796
Cdd:cd17533    3 IFILEDDKIQRVRLEEIIENI----LKIENIEYVIELTgkteellekikerGKNGIYFLDIDIKMEEKNGLEVAQKIRKY 78


                 ....*..
gi 942463857 797 SPQTPII 803
Cdd:cd17533   79 DPYAIII 85
PRK11173 PRK11173
two-component response regulator; Provisional
 728-786 2.94e-04

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 43.47  E-value: 2.94e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 942463857 728 PTVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNG 786
Cdd:PRK11173   4 PHILIVEDELVTRNTLKSIFEAEGYDVFEATDGAEMHQILSENDINLVIMDINLPGKNG 62
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 582-636 3.99e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 40.49  E-value: 3.99e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 942463857 582 VIFNLIRNAIyyfdSYPDSQIEISTKIDSYENVLIFRDTGPGIDEAIAHKIFDDF 636
Cdd:cd16939    4 ALDNLLRNAL----RYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPF 54
REC_RocR cd17530
phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR ...
 729-838 4.15e-04

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381086 [Multi-domain]  Cd Length: 123  Bit Score: 40.89  E-value: 4.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 729 TVLIVDDKEVQRTLVQMYLSRLGVNSLQ-AKNGENAVELFRTHKVDLILMDVQMPIMNG-----------FDASQIIKar 796
Cdd:cd17530    2 RVLVLDDDPFQCMMAATILEDLGPGNVDeADDGREALVILLCNAPDIIICDLKMPDMDGieflrhlaeshSNAAVILM-- 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 942463857 797 SPQTPIIALSGESGQRELEMinQLMdGRLEKPTSLNALQHVL 838
Cdd:cd17530   80 SGLDGGILESAETLAGANGL--NLL-GTLSKPFSPEELTELL 118
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 582-680 4.18e-04

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 43.75  E-value: 4.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 582 VIFNLIRNAIYYFDSYPDSQIEISTkidSYEN-VLIFR--DTGPGIDEAIAHKIFDDFFSyQKSGGSGLGLGYCQRVMRS 658
Cdd:PRK11086 437 ILGNLIENALEAVGGEEGGEISVSL---HYRNgWLHCEvsDDGPGIAPDEIDAIFDKGYS-TKGSNRGVGLYLVKQSVEN 512

                         90       100
                 ....*....|....*....|..
gi 942463857 659 FGGRVECHSKLGEFTEFHLYFP 680
Cdd:PRK11086 513 LGGSIAVESEPGVGTQFFVQIP 534
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 730-811 4.60e-04

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 40.26  E-value: 4.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSpQTPIIALSGES 809
Cdd:cd17621    1 VLVVEDEESFSDPLAYLLRKEGFEVTVATDGPAALAEFDRAGADIVLLDLMLPGLSGTEVCRQLRARS-NVPVIMVTAKD 79


                 ..
gi 942463857 810 GQ 811
Cdd:cd17621   80 SE 81
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 468-666 5.14e-04

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 43.68  E-value: 5.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 468 SIAHEMRNPLAQVQLHFEVLKQHIdnqaPAKQILLDIENGQAAIQRGRQLIDIILREvsdSSPE--HGPVTMTSIHKA-- 543
Cdd:PRK11100 262 TLTHELKSPLAAIRGAAELLQEDP----PPEDRARFTGNILTQSARLQQLIDRLLEL---ARLEqrQELEVLEPVALAal 334

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 544 VDQAVSHY--GFENEKIIERIRLPqhaDFVVKLNETLFNFVIFNLIRNAIYYfdSYPDSQIEISTKIDSYENVLIFRDTG 621
Cdd:PRK11100 335 LEELVEAReaQAAAKGITLRLRPD---DARVLGDPFLLRQALGNLLDNAIDF--SPEGGTITLSAEVDGEQVALSVEDQG 409

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 942463857 622 PGI-DEAIAhKIFDDFFSYQKSGGSGLGL----GYCQRVMRSFGGRVECH 666
Cdd:PRK11100 410 PGIpDYALP-RIFERFYSLPRPANGRKSTglglAFVREVARLHGGEVTLR 458
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
729-809 7.80e-04

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 41.79  E-value: 7.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 729 TVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGEN--AVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALS 806
Cdd:PRK09935   5 SVIIMDTHPIIRMSIEVLLQKNSELQIVLKTDDYriTIDYLRTRPVDLIIMDIDLPGTDGFTFLKRIKQIQSTVKVLFLS 84


                 ...
gi 942463857 807 GES 809
Cdd:PRK09935  85 SKS 87
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 729-806 1.99e-03

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 38.90  E-value: 1.99e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 942463857 729 TVLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKaRSPQTPIIALS 806
Cdd:cd19938    1 RILIVEDEPKLAQLLIDYLRAAGYAPTLLAHGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREIR-RFSDVPIIMVT 77
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
729-809 2.49e-03

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 40.26  E-value: 2.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 729 TVLIVDDKEVQRTLVQMYLSRLGVNSL-QAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALSG 807
Cdd:PRK09958   2 NAIIIDDHPLAIAAIRNLLIKNDIEILaELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVSA 81


                 ..
gi 942463857 808 ES 809
Cdd:PRK09958  82 KN 83
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 730-806 2.65e-03

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 40.29  E-value: 2.65e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 942463857 730 VLIVDDKEVQRTLVQMYLSRLGVNSLQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALS 806
Cdd:PRK09836   3 LLIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKGMPILLLT 79
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 582-637 4.03e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 37.75  E-value: 4.03e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 942463857 582 VIFNLIRNAIYYfdSYPDSQIEIsTKIDSYENVLI-FRDTGPGIDEAIAHKIFDDFF 637
Cdd:cd16923    4 VFSNLLSNAIKY--SPENTRIYI-TSFLTDDVVNImFKNPSSHPLDFKLEKLFERFY 57
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 583-664 4.91e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 37.44  E-value: 4.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 583 IFNLIRNAIyyfDSYPDS-QIEISTKIDSYENVLIFRDTGPGIDEAIAHKIFDDFFSYQKSGGSGLGL----GYCQRVMR 657
Cdd:cd16945    9 INNLLDNAI---DFSPEGgLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKSTglglAFVQEVAQ 85


                 ....*..
gi 942463857 658 SFGGRVE 664
Cdd:cd16945   86 LHGGRIT 92
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 579-680 6.21e-03

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 37.36  E-value: 6.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 579 FNFVIFNLIRNAiyyFDSYPDS-QIEISTKIDSYEN---------------VLIFRDTGPGIDEAIAHKIFDDFFSYQ-- 640
Cdd:cd16919    1 LELAILNLAVNA---RDAMPEGgRLTIETSNQRVDAdyalnyrdlipgnyvCLEVSDTGSGMPAEVLRRAFEPFFTTKev 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 942463857 641 -KSGGSGLGLGYcqRVMRSFGGRVECHSKLGEFTEFHLYFP 680
Cdd:cd16919   78 gKGTGLGLSMVY--GFVKQSGGHLRIYSEPGVGTTVRIYLP 116
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 577-637 6.85e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 37.39  E-value: 6.85e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 942463857 577 TLFNFVIFNLIRNAIYYfdSYPDSQIEISTKIDSYENVLIfRDTGPGIDEAIAHKIFDDFF 637
Cdd:cd16940   12 LLLFLLLRNLVDNAVRY--SPQGSRVEIKLSADDGAVIRV-EDNGPGIDEEELEALFERFY 69
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
730-834 8.24e-03

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 38.68  E-value: 8.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942463857 730 VLIVDDKEVQRTLVQMYL---SRLGVNSlQAKNGENAVELFRTHKVDLILMDVQMPIMNGFDASQIIKARSPQTPIIALS 806
Cdd:PRK10403   9 VLIVDDHPLMRRGVRQLLeldPGFEVVA-EAGDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILT 87

                         90       100
                 ....*....|....*....|....*....
gi 942463857 807 GESGQREL-EMINQLMDGRLEKPTSLNAL 834
Cdd:PRK10403  88 VSDASSDVfALIDAGADGYLLKDSDPEVL 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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