|
Name |
Accession |
Description |
Interval |
E-value |
| TrpE |
COG0147 |
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, ... |
12-456 |
1.01e-164 |
|
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Anthranilate/para-aminobenzoate synthases component I is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis
Pssm-ID: 439917 [Multi-domain] Cd Length: 416 Bit Score: 470.74 E-value: 1.01e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 12 RKPKYVTISSDCDFFGMFKKVEKQfANCFMLESLGEESYISRHSIIGFDPEKLLWAEGNTLFIqeRDGETASYESDNPYY 91
Cdd:COG0147 2 RIPVYRELLALETPVSLFLKLADG-PYAFLLESAEGGEKWGRYSFIGADPLATLTVRGGRVTI--EGGGEVEPSEGDPLD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 92 LLRSIVPQNIISRG-----YAGGLTGYIGYDAMNYFE--PTLNLQTSDMFDgFRFGLYKDGLILDKMTGQVFyfyydqdr 164
Cdd:COG0147 79 ALRALLARFRLPPLpglppFTGGLVGYFGYDLVRYFErlPDLAPDDLGLPD-AALGLYDRLLVFDHLKGTRS-------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 165 selvqslldapvpengslvvtpageSMTREEHAQAVAKVKQDIIDGKIFQTEVGFKKWFDLEGDTIAIYEQMRIVNPSPQ 244
Cdd:COG0147 150 -------------------------NFTREEYLAAVERAKEYIRAGDIFQVVLSQRFSAPFEGDPLALYRALRRINPSPY 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 245 MYYLKFGEQKVIGASPELLFRLRQGEMETFPLAGTAKRGVDEKEDVALARALLNDPKEIAEHNMIVDLHRNDIGRVARFG 324
Cdd:COG0147 205 MFYLRFGDFAIVGSSPERLVRVEDGRVETRPIAGTRPRGATPEEDAALAEELLADEKERAEHLMLVDLARNDLGRVCEPG 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 325 TVKVRSLMDIKRFSHVQHISSEIVGIIADDQDMFSALASNFPAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGQFSFNG 404
Cdd:COG0147 285 SVKVPELMVVERYSHVMHLVSTVTGRLRPGLDALDALRATFPAGTLTGAPKIRAMEIIDELEPTRRGVYGGAVGYLSFDG 364
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 943635177 405 DCHFAIPIRTVFAKGNKAYVQTCGGNVYDSNAEGEYEEIQRKFAGTKRVLDQ 456
Cdd:COG0147 365 NMDLAIAIRTAVVKDGRAYVQAGAGIVADSDPEAEYQETLNKARALLRALEL 416
|
|
| TrpE-arch |
TIGR01820 |
anthranilate synthase component I, archaeal clade; This model represents an archaeal clade of ... |
26-455 |
9.68e-135 |
|
anthranilate synthase component I, archaeal clade; This model represents an archaeal clade of anthranilate synthase component I enzymes. This enzyme is responsible for the first step of tryptophan biosynthesis from chorismate. The Sulfolobus enzyme has been reported to be part of a gene cluster for Trp biosynthesis [Amino acid biosynthesis, Aromatic amino acid family]
Pssm-ID: 273819 [Multi-domain] Cd Length: 435 Bit Score: 395.19 E-value: 9.68e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 26 FGMFKKVEKQFANCFMLESLGEESYISRHSIIGFDPEKLLWAEGNTLF--IQERDGETASYESdNPYYLLRSIVPQNIiS 103
Cdd:TIGR01820 2 LELYKAIRADGDYAFLLESAEKPSKKARYSFIGWDPEFVVRINGKGKSveGIPEDGDVVDKLR-NAFPKLKGINIPGE-D 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 104 RGYAGGLTGYIGYDAM-NYFEPTLNLQTSDMFDGF-RFGLYKDGLILDKMTGQVFYFYYDQDRSEL---VQSLLDAPVPE 178
Cdd:TIGR01820 80 RRFKGGLVGYIAYDAVrDYWEGIVDLKRKAEDWPPaEFFIYPNTIVYDHLEGKVYYVSTPEPEAELeriVERAKRATDPG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 179 NGSLVVTPAGESmTREEHAQAVAKVKQDIIDGKIFQTEVGFKKWFDLEGDTIAIYEQMRIVNPSPQMYYLKFGEQKVIGA 258
Cdd:TIGR01820 160 EAGVSFEGESLS-DREEFEEAVEEAKEYIFAGDIFQVVLSREYEYRLDGDPFELYYNLREINPSPYMFLLKFGDRYLVGS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 259 SPELLFRLRQGEMETFPLAGTAKRGVDEKEDVALARALLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKVRSLMDIKRFS 338
Cdd:TIGR01820 239 SPETLVRVEGRTVETNPIAGTRPRGATPEEDERLAKELLSDEKERAEHVMLVDLARNDVRKVSEPGSVKVPEFMYVEKYS 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 339 HVQHISSEIVGIIADDQDMFSALASNFPAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGQFSFNGDCHFAIPIRTVFAK 418
Cdd:TIGR01820 319 HVQHIESTVIGTLKKDYDAFDALRATFPAGTLSGAPKIRAMEIIDELEKEPRGVYGGGVGYFSWNGDADFAIAIRTAEID 398
|
410 420 430
....*....|....*....|....*....|....*..
gi 943635177 419 GNKAYVQTCGGNVYDSNAEGEYEEIQRKFAGTKRVLD 455
Cdd:TIGR01820 399 KDKLRIQAGAGIVADSIPEREFEETENKMKAVLKAIG 435
|
|
| trpE_most |
TIGR00564 |
anthranilate synthase component I, non-proteobacterial lineages; This enzyme resembles some ... |
40-455 |
4.79e-130 |
|
anthranilate synthase component I, non-proteobacterial lineages; This enzyme resembles some other chorismate-binding enzymes, including para-aminobenzoate synthase (pabB) and isochorismate synthase. There is a fairly deep split between two sets, seen in the pattern of gaps as well as in amino acid sequence differences. Archaeal enzymes have been excluded from this model (and are now found in TIGR01820) as have a clade of enzymes which constitute a TrpE paralog which may have PabB activity (TIGR01824). This allows the B. subtilus paralog which has been shown to have PabB activity to score below trusted to this model. This model contains sequences from gram-positive bacteria, certain proteobacteria, cyanobacteria, plants, fungi and assorted other bacteria.A second family of TrpE enzymes is modelled by TIGR00565. The breaking of the TrpE family into these diverse models allows for the separation of the models for the related enzyme, PabB. [Amino acid biosynthesis, Aromatic amino acid family]
Pssm-ID: 273142 [Multi-domain] Cd Length: 454 Bit Score: 383.99 E-value: 4.79e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 40 FMLESLGEESYISRHSIIGFDPEKLLWAEGNTLfIQERDGETASYEsDNPYYLLRSIVPQNIISR------GYAGGLTGY 113
Cdd:TIGR00564 19 FLLESAEPGSERGRYSFIGLNPVLTIKTEGGTE-YLGADDRRSGIV-GNPLDEIRDVMETFAQHSdpelpiPFTGGAVGY 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 114 IGYDAMNYFEP-TLNLQ-TSDMFDGfRFGLYKDGLILDKMTGQVF---YFYYDQDRS----------ELVQSLLDAPVPE 178
Cdd:TIGR00564 97 LGYDTVRLFEKiTLPPPdPLNLPDA-YLMLCDDFIIFDHVTDKLYlihNNRTTASRSakaaadarleALVADLQDPLLPE 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 179 NGSLVVT--PAGESMTREEHAQAVAKVKQDIIDGKIFQTEVGFKKWFDLEGDTIAIYEQMRIVNPSPQMYYLKFGEQKVI 256
Cdd:TIGR00564 176 VPVPYPAalSFTSNYEKEEYEANVAKAKEYIKAGDIFQVVLSQRFEAKTEAPPFELYRVLRIVNPSPYMYYLDFGDFQIV 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 257 GASPELLFRLRQGEMETFPLAGTAKRGVDEKEDVALARALLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKVRSLMDIKR 336
Cdd:TIGR00564 256 GSSPELLVKVTGGRITTRPIAGTRKRGATPEEDEALAEELLADEKERAEHLMLVDLGRNDIGRVCEPGSVEVPEFMKIER 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 337 FSHVQHISSEIVGIIADDQDMFSALASNFPAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGQFSFNGDCHFAIPIRTVF 416
Cdd:TIGR00564 336 YSHVMHIVSTVEGRLKDGLTAIDALRATFPAGTVSGAPKIRAMELIDELEPEKRGIYGGAVGYLSFDGDMDTAIAIRTMV 415
|
410 420 430
....*....|....*....|....*....|....*....
gi 943635177 417 AKGNKAYVQTCGGNVYDSNAEGEYEEIQRKFAGTKRVLD 455
Cdd:TIGR00564 416 VKDGKAYVQAGGGIVADSDPEAEYEETLNKARALLRAIE 454
|
|
| Chorismate_bind |
pfam00425 |
chorismate binding enzyme; This family includes the catalytic regions of the chorismate ... |
194-446 |
8.22e-102 |
|
chorismate binding enzyme; This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.
Pssm-ID: 425674 [Multi-domain] Cd Length: 255 Bit Score: 304.48 E-value: 8.22e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 194 EEHAQAVAKVKQDIIDGKIFQ----TEvgFKKWFDLEGDTIAIYEQMRIVNPSPQMYYLKFGEQKVIGASPELLFRLRQG 269
Cdd:pfam00425 1 EDYLAAVEKAKEAIRAGDLYKvvlsRR--LTLPLAGDIDPLALYRRLRARNPAPYSFYFRTGDFTFLGASPERLLSVDGG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 270 EMETFPLAGTAKRGVDEKEDVALARALLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKVRSLMDIKRFSHVQHISSEIVG 349
Cdd:pfam00425 79 RIITEPIAGTRPRGKDPAEDEALAAELLADPKERAEHLMVVDLIRNDLGRVCVPGSVKVPELPEVERYGTVQHLVSTISG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 350 IIADDQDMFSALASNFPAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGQFSFNGDCHFAIPIRTVFAKGNKAYVQTCGG 429
Cdd:pfam00425 159 RLKPGLSLLDLLKALFPTGAVTGAPKKRAMEIIRELEPFPRGLYAGAVGYLDPDGDADFAVAIRTALVDNGRARLYAGAG 238
|
250
....*....|....*..
gi 943635177 430 NVYDSNAEGEYEEIQRK 446
Cdd:pfam00425 239 IVADSDPEAEWEETEAK 255
|
|
| PRK13572 |
PRK13572 |
anthranilate synthase component I; Provisional |
34-455 |
7.24e-101 |
|
anthranilate synthase component I; Provisional
Pssm-ID: 237432 [Multi-domain] Cd Length: 435 Bit Score: 308.59 E-value: 7.24e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 34 KQFANCFMLESLGEESYISRHSIIGFDPEKLLWAEGNTlfiqERDGETASYESdNPYYLLRSIVPQNIISRGYAGGLTGY 113
Cdd:PRK13572 19 RDEGYPFILESAEKGQRKARYTYISANPEFMVRIGNKT----KVDGETISKES-NPFKALKENFKITQSGDRFTGGFVGY 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 114 IGYDAM-NYFEptlnlqtSDMFDGFRFGLYKDGLILDKMTGQvFYFYYDQDRSE-------LVQSLLDAPVP-ENGSLVV 184
Cdd:PRK13572 94 IAYDAVhNYIG-------GKIEEPSVFGYYDHVFVYDHVTRK-FYFHSLNNNPEelfnaekIVEKAKRFEIEeEDGGSEV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 185 tpAGESMTREEHAQAVAKVKQDIIDGKIFQTEVGFKKWFDLEGDTIAIYEQMRIVNPSPQMYYLKFgEQKVIGASPELLF 264
Cdd:PRK13572 166 --LGCDADREEFVEMVEKAKEYIYSGDVFQVVLSREYRLKTDLSPFQLYRNLREINPSPYMFLLEF-DKDVVGASPETMA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 265 RLRQGEMETFPLAGTAKRGVDEKEDVALARALLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKVRSLMDIKRFSHVQHIS 344
Cdd:PRK13572 243 SVENNILKINPIAGTAPRGKTEEEDKKLAEALLSDEKERAEHVMLVDLARNDVRKVSKSGSVRLERFFDVVKYSHVQHIE 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 345 SEIVGIIADDQDMFSALASNFPAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGQFSFNGDCHFAIPIRTVFAKGnKAYV 424
Cdd:PRK13572 323 SEVVGELKEDSTMFDAIEAAFPAGTLTGAPKFRAMEIIDELEKSRRKVYGGAVGYFSNSGNADLAIAIRMAEIDK-VCRV 401
|
410 420 430
....*....|....*....|....*....|.
gi 943635177 425 QTCGGNVYDSNAEGEYEEIQRKFAGTKRVLD 455
Cdd:PRK13572 402 RAGAGIVADSVPEKEFYETERKMAAVLKALG 432
|
|
| PRK13574 |
PRK13574 |
anthranilate synthase component I; Provisional |
19-451 |
1.08e-95 |
|
anthranilate synthase component I; Provisional
Pssm-ID: 184155 [Multi-domain] Cd Length: 420 Bit Score: 294.80 E-value: 1.08e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 19 ISSDCDFFGMFKKVEKQFANCFMLESLGEESYISRHSIIGfdpekllWAEGNTLFI-QERDGETASYESDnpyyllrsiV 97
Cdd:PRK13574 6 INEFASPFEVFKCIERDFKVAGLLESIGGPQYKARYSVIA-------WGTNGYLKIhDDPVNILNSYLKD---------L 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 98 PQNIISRGYAGGLTGYIGYDAMNYFEPTLNLQTS-DMFDGFRFGLYKDGLILDKMTGQVfyfYYDQDRSELvqslldAPV 176
Cdd:PRK13574 70 KLVDIPGLFKGGMIGYISYDAVRFWEKIRDLKPAaEDWPYAEFFIPDNIIIYDHNEGKV---YVNGDLSSV------GGC 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 177 PENGSLVVTPAGESMTREEHAQAVAKVKQDIIDGKIFQTEVGFKKWFDLEGDTIAIYEQMRIVNPSPQMYYLKFGEQKVI 256
Cdd:PRK13574 141 GDMGEFKISFYDESLNKNNYEKIVSESLEYIRSGYIFQVVLSRFYRYLFSGDPLRIYYNLRRINPSPYMFYLKFDERYLI 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 257 GASPELLFRLRQGEMETFPLAGTAKRGVDEKEDVALARALLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKVRSLMDIKR 336
Cdd:PRK13574 221 GSSPELLFRVQDNIVETYPIAGTRPRGSDQEEDLKLELELMNSEKDKAEHLMLVDLARNDLGKVCVPGTVRVPELMYVEK 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 337 FSHVQHISSEIVGIIADDQDMFSALASNFPAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGQFSFNGDCHFAIPIRTVF 416
Cdd:PRK13574 301 YSHVQHIVSKVIGTLKKKYNALDVLKATFPAGTVSGAPKPMAMNIIETLEEYKRGPYAGAVGFISADGNAEFAIAIRTAF 380
|
410 420 430
....*....|....*....|....*....|....*
gi 943635177 417 AKGNKAYVQTCGGNVYDSNAEGEYEEIQRKFAGTK 451
Cdd:PRK13574 381 LNKDLLRIQAGAGIVYDSNPESEYFETEHKLRALK 415
|
|
| PLN02445 |
PLN02445 |
anthranilate synthase component I |
40-455 |
4.00e-95 |
|
anthranilate synthase component I
Pssm-ID: 215244 [Multi-domain] Cd Length: 523 Bit Score: 296.59 E-value: 4.00e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 40 FMLESL---GEESYISRHSIIGFDPEKLLWAEGNTLFIQERDGETASYES-DNPYYLLRSIV----PQNI--ISRGYAGG 109
Cdd:PLN02445 42 FLFESVepgSQSSNVGRYSVVGAQPAMEIVAKENKVTIMDHEKGTRTEEIvEDPMEIPRRISekwnPQLIdgLPDVFCGG 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 110 LTGYIGYDAMNYFE---------PTLNLQTSDMfdgfRFGLYKDGLILDKMTGQVFYFYY---DQDRS------------ 165
Cdd:PLN02445 122 WVGYFSYDTVRYVEkkklpfsgaPEDDRNLPDI----HLGLYDDVIVFDHVEKKAYVIHWvrlDRYSSveeayedgmkrl 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 166 -ELVQSLLDAPVPE--NGSLVV------TPAGES-MTREEHAQAVAKVKQDIIDGKIFQteVGFKKWFdlEGDTIA---- 231
Cdd:PLN02445 198 eALVSRLQDINPPKlsPGSVKLstnqfgPSLEKSnMTSEEYKNAVLQAKEHILAGDIFQ--IVLSQRF--ERRTFAdpfe 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 232 IYEQMRIVNPSPQMYYLKFGEQKVIGASPELLFRLRQGEMETFPLAGTAKRGVDEKEDVALARALLNDPKEIAEHNMIVD 311
Cdd:PLN02445 274 VYRALRIVNPSPYMIYLQARGCILVASSPEILTRVKKNKIVNRPLAGTRRRGKTPEEDKALEKDLLADEKQCAEHIMLVD 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 312 LHRNDIGRVARFGTVKVRSLMDIKRFSHVQHISSEIVGIIADDQDMFSALASNFPAGTLTGAPKIEAMKIIDDMEGDGRG 391
Cdd:PLN02445 354 LGRNDVGKVSKAGSVKVEKLMNIERYSHVMHISSTVTGELLDHLTSWDALRAALPVGTVSGAPKVRAMELIDELEVTRRG 433
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 392 PYGGAVGQFSFNGDCHFAIPIRT-VFAKGNK-----------------AYVQTCGGNVYDSNAEGEYEEIQRKFAGTKRV 453
Cdd:PLN02445 434 PYSGGFGGVSFTGDMDIALALRTmVFPTAARydtmysykdtnsrrewvAHLQAGAGIVADSDPEDEYRECVNKAAGLARA 513
|
..
gi 943635177 454 LD 455
Cdd:PLN02445 514 ID 515
|
|
| PRK13571 |
PRK13571 |
anthranilate synthase component I; Provisional |
40-461 |
5.99e-92 |
|
anthranilate synthase component I; Provisional
Pssm-ID: 184152 [Multi-domain] Cd Length: 506 Bit Score: 287.69 E-value: 5.99e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 40 FMLESLGEESYISRHSIIGFDPEKLLwaegntlfiQERDGETASY--------ESDNPYYLLRSIVPQNIISR-----GY 106
Cdd:PRK13571 51 FLLESAENGRSWSRWSFIGVGSPAAL---------TVRDGEAVWLgtppagapTGGDPLAALRATLELLATPRlpglpPL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 107 AGGLTGYIGYDAMNYFEPTLNLQTSDM-FDGFRFGLYKDGLILDKMTGQVFYF----------------YYD-QDRSELV 168
Cdd:PRK13571 122 TGGMVGFLGYDAVRRLERLPELAVDDLgLPEMLLLLATDLAAVDHHEGTITLIanavnwngtdervdaaYDDaVARLDVM 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 169 QSLLDAPVPENGSLVVTPAGE---SMTREEHAQAVAKVKQDIIDGKIFQTEVGFKKWFDLEGDTIAIYEQMRIVNPSPQM 245
Cdd:PRK13571 202 TAALAQPLPSTVATFSRPVPEfraQRTVEEFGAAVEKLVEEIRAGEAFQVVPSQRFEMDTTADPLDVYRVLRVTNPSPYM 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 246 YYLKFGEQK------VIGASPELLFRLRQGEMETFPLAGTAKRGVDEKEDVALARALLNDPKEIAEHNMIVDLHRNDIGR 319
Cdd:PRK13571 282 YLLRVPNSDggtdfsIVGSSPEALVTVTDGRATTHPIAGTRWRGATPEEDALLEKELLADPKERAEHLMLVDLGRNDLGR 361
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 320 VARFGTVKVRSLMDIKRFSHVQHISSEIVGIIADDQDMFSALASNFPAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGQ 399
Cdd:PRK13571 362 VCRPGTVRVVDFSHIERYSHVMHLVSTVTGELAEGRTALDAVTACFPAGTLSGAPKVRAMELIEELEPTRRGLYGGVVGY 441
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 943635177 400 FSFNGDCHFAIPIRTVFAKGNKAYVQTCGGNVYDSNAEGEYEEIQRKFAGtkrVLDQFAPAQ 461
Cdd:PRK13571 442 LDFAGDADTAIAIRTALMRDGTAYVQAGGGVVADSDPDYEDNEARNKAAA---VLRAIAAAE 500
|
|
| pabB |
TIGR00553 |
aminodeoxychorismate synthase, component I, bacterial clade; Members of this family, ... |
110-446 |
5.38e-81 |
|
aminodeoxychorismate synthase, component I, bacterial clade; Members of this family, aminodeoxychorismate synthase, component I (PabB), were designated para-aminobenzoate synthase component I until it was recognized that PabC, a lyase, completes the pathway of PABA synthesis. This family is closely related to anthranilate synthase component I (trpE), and both act on chorismate. The clade of PabB enzymes represented by this model includes sequences from Gram-positive and alpha and gamma Proteobacteria as well as Chlorobium, Nostoc, Fusobacterium and Arabidopsis. A closely related clade of fungal PabB enzymes is identified by TIGR01823, while another bacterial clade of potential PabB enzymes is more closely related to TrpE (TIGR01824). [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]
Pssm-ID: 273133 Cd Length: 328 Bit Score: 253.84 E-value: 5.38e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 110 LTGYIGYDAMnyfeptlnlqtsdmfDGFRFGLYKDGLILD----KMTGQVFYFYYDQDRSELVQSLLDAPVpeNGSLVVT 185
Cdd:TIGR00553 1 LVGYLSYEAG---------------PDAAFEPYDAALLADhrrtPLLRFLVFERVEAQPRAAVEAEDDAPA--DRQAPTS 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 186 PAGESMTREEHAQAVAKVKQDIIDGKIFQTEVGFKKWFDLEGDTIAIYEQMRIVNPSPQMYYLKFGEQKVIGASPELLFR 265
Cdd:TIGR00553 64 DIQSEMTRAEYGEAIDQLQDYIRAGDCYQANLTQQFHATWDGDPLAAFRKLRRRQPAPFSAFLDLGDGAILSLSPELFFS 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 266 LRQGEMETFPLAGTAKRGVDEKEDVALARALLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKVRSLMDIKRFSHVQHISS 345
Cdd:TIGR00553 144 IDGSEIETRPIKGTLPRGADPQEDRAQASALAESAKDRAENLMIVDLLRNDLGRIAEVGSVKVPELFVVETYPTVHQLVS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 346 EIVGIIADDQDMFSALASNFPAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGQFSFNGDCHFAIPIRTVFAKGNKAYVQ 425
Cdd:TIGR00553 224 TITARLREDLTLSDLFRALFPGGSITGAPKVRAMEIIDELEPQPRGVYCGAIGYLSPEGDMDFNVAIRTLTLDGGRAVYG 303
|
330 340
....*....|....*....|.
gi 943635177 426 TCGGNVYDSNAEGEYEEIQRK 446
Cdd:TIGR00553 304 VGGGIVADSDPEAEYRECLLK 324
|
|
| PabB-clade2 |
TIGR01824 |
aminodeoxychorismate synthase, component I, clade 2; This clade of sequences is more closely ... |
108-449 |
2.52e-76 |
|
aminodeoxychorismate synthase, component I, clade 2; This clade of sequences is more closely related to TrpE (anthranilate synthase, TIGR00564/TIGR01820/TIGR00565) than to the better characterized group of PabB enzymes (TIGR00553/TIGR01823). This clade includes one characterized enzyme from Lactococcus and the conserved function across the clade is supported by these pieces of evidence: 1) all genomes with a member in this clade also have a separate TrpE gene, 2) none of these genomes contain an aparrent PabB from any of the other PabB clades, 3) none of these sequences are found in a region of the genome in association with other Trp biosynthesis genes, 4) all of these genomes aparrently contain most if not all of the steps of the folate biosynthetic pathway (for which PABA is a precursor). Many of the sequences hit by this model are annotated as TrpE enzymes, however, we believe that all members of this clade are, in fact, PabB. The sequences from Bacillus halodurans and subtilus which score below the trusted cutoff for this model are also likely to be PabB enzymes, but are too closely related to TrpE to be separated at this time.
Pssm-ID: 130883 Cd Length: 355 Bit Score: 242.76 E-value: 2.52e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 108 GGLTGYIGYDAMNYFEPTLNLQTSDMF----DGFRFGLykdGLILDKMTGQVFYFYYDQD------RSELVQSLLDAPVP 177
Cdd:TIGR01824 1 GGRLGWLAYDVARRLEGIPDLGTSDGGwpvaADFRYEA---AVARDHQRQIVALATVPAEtegefaTSSDQLPAVAAATS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 178 ENGSLVVTPAGE---SMTREEHAQAVAKVKQDIIDGKIFQTEVGfKKW---FDLEGDTIAIYEQMRIVNPSPQMYYLKFG 251
Cdd:TIGR01824 78 LPSPDVGPLPVDleaSIDRAAYETGVRRIKDYIRAGDVFQANLS-RRLtapIAADVDPLQLFLALRAPNPAPYAIYLEEP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 252 EQKVIGASPELLFRLRQGEMETFPLAGTAKRGVDEKEDVALARALLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKVRSL 331
Cdd:TIGR01824 157 GVDVASASPELFLAREGRVVQTRPIAGTRPRGATLAEDGALAAELLQHDKDRAEHVMIVDLERNDLGRVCATGTVRVPEL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 332 MDIKRFSHVQHISSEIVGIIADDQDMFSALASNFPAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGQFSFNGDCHFAIP 411
Cdd:TIGR01824 237 CAVESYSHVHHLVSRVTGRLREGAGLADLIRALFPGGSITGAPKVRAMEIIDELEPQPRGPYTGSVGWIDADGNADLNIL 316
|
330 340 350
....*....|....*....|....*....|....*...
gi 943635177 412 IRTVFAKGNKAYVQTCGGNVYDSNAEGEYEEIQRKFAG 449
Cdd:TIGR01824 317 IRTLEGGGAQLHFRTGAGIVADSDPAGEWDETEAKARA 354
|
|
| PRK09070 |
PRK09070 |
aminodeoxychorismate synthase component I; |
40-457 |
5.67e-73 |
|
aminodeoxychorismate synthase component I;
Pssm-ID: 236371 [Multi-domain] Cd Length: 447 Bit Score: 236.91 E-value: 5.67e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 40 FMLESLGEESYISRHSIIGFDPEKLLWAEGNTlfiQERDGETASYESDNPYYLLRSIVPQNIISR-GYAGGLTGYIGYDA 118
Cdd:PRK09070 26 ALLESSASGTAQGRWDVLLLAQGKCLRLDPDG---VTRQLLEGDFLDALDAAWQAERVPHDGESSlPFRGGWAVLLDYEL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 119 MNYFEPTLNLQTSDmfDGFRFGL---YKDGLILDKMTGQvFYFYYDQDRSELVQSLLD--APVPENGSLVVTPAGESMTR 193
Cdd:PRK09070 103 AGQVEPILKLPMRT--DGLPLALalrAPAAVLRDRHSGR-CVLVAEPGREHLLDQIEAdlAACAALPPLPVWLAPQAVEE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 194 EEHAQ---AVAKVKQDIIDGKIFQTEVGfKKW---FDLEGDTIAIYEQMRIVNPSPQMYYLKFGEQKVIGASPELLFRLR 267
Cdd:PRK09070 180 DPPERftdGVERVLDYIRAGDVFQVNLS-RAWqaqFANAVDPAALYARLRAANPAPFSGLFVAAGRAIVSSSPERLVSVQ 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 268 QGEMETFPLAGTAKRGVDEkEDVALARALLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKVRSLMDIKRFSHVQHISSEI 347
Cdd:PRK09070 259 GGVVQTRPIAGTRPRFAGD-DDAALIRELVGHPKERAEHVMLIDLERNDLGRICAPGSVEVDELMTVESYAHVHHIVSNV 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 348 VGIIADD---QDMFSALasnFPAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGQFSFNGDCHFAIPIRTVFAKGNKAYV 424
Cdd:PRK09070 338 RGRLRDGvtpGEVIRAV---FPGGTITGCPKVRCMQIIAELEQTPRGAYTGSFGYLNRDGDMDLNILIRTAEVQGNQVRF 414
|
410 420 430
....*....|....*....|....*....|...
gi 943635177 425 QTCGGNVYDSNAEGEYEEIQRKFAGTKRVLDQF 457
Cdd:PRK09070 415 RTGAGIVVDSDPERELDETRAKARGLLRALEQA 447
|
|
| PRK07508 |
PRK07508 |
aminodeoxychorismate synthase component I; |
102-449 |
2.87e-63 |
|
aminodeoxychorismate synthase component I;
Pssm-ID: 236035 [Multi-domain] Cd Length: 378 Bit Score: 209.48 E-value: 2.87e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 102 ISRGYAGG--LTGYIGYDAMNYFEPTLnlqTSDMFDGFRFGLykdglildkMTGQVFyfyydqdRSELVQSLLDAPVPEN 179
Cdd:PRK07508 38 MERARAAGkwLAGYLSYEAGYLLEPKL---APLMPEGRETPL---------LCFGVF-------DAPSPEAPAPARPSEN 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 180 GSLVVTPAGeSMTREEHAQAVAKVKQDIIDGKIFQTEVGFKKWFDLEGDTIAIYEQMRIVNPSPQMYYLKFGEQKVIGAS 259
Cdd:PRK07508 99 AARLRDPVA-RWDFADYAQRFERLHRHIRAGDCYQANLTFPLDARWGGDPLALFWALAARQPVGYGALVDLGGPVILSRS 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 260 PELLFRLR-QGEMETFPLAGTAKRGVDEKEDVALARALLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKVRSLMDIKRFS 338
Cdd:PRK07508 178 PELFFRVDgEGWIETHPMKGTAPRGATPAEDARLRAALLNDEKNQAENRMIVDLLRNDISRISEVGSLDVPELFDIETYP 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 339 HVQHISSEIVGIIADD---QDMFSALasnFPAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGQFSFNGDCHFAIPIRT- 414
Cdd:PRK07508 258 TVHQMVSRVRARLLPGlglADIFAAL---FPCGSITGAPKIRAMEILRELEPGPRDLYCGAIGWIAPDGRMRFNVAIRTl 334
|
330 340 350
....*....|....*....|....*....|....*..
gi 943635177 415 VFAKGNKAYVQTCGGNVYDSNAEGEYEEIQRK--FAG 449
Cdd:PRK07508 335 SLFPGGRAVFNVGGGIVFDSTAEAEYEECLLKarFAV 371
|
|
| pabB |
PRK15465 |
aminodeoxychorismate synthase component 1; |
52-457 |
5.82e-61 |
|
aminodeoxychorismate synthase component 1;
Pssm-ID: 185362 [Multi-domain] Cd Length: 453 Bit Score: 205.54 E-value: 5.82e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 52 SRHSIIGFDPEKLLWAEGNTLFIqeRDGETASYESDNPYYLLR------SIVPQNIISRGYAGGLTGYIGYDAMNYFE-- 123
Cdd:PRK15465 44 SRFDIVVADPICTLTTFGKETVV--SESEKRTTTTDDPLQVLQqvldraDIRPTHNEDLPFQGGALGLFGYDLGRRFEsl 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 124 PTLNLQTSDMFDgFRFGLYKDGLILDKMTGQVFYFYYDQDRSELvQSLLDAPVPENGSLVVTPAGES-MTREEHAQAVAK 202
Cdd:PRK15465 122 PEIAEQDIVLPD-MAVGIYDWALIVDHQRQTVSLLSHNDVNARR-AWLESQQFSPQEDFTLTSDWQSnMTREQYGEKFRQ 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 203 VKQDIIDGKIFQTEVGFKKWFDLEGDTIAIYEQMRIVNPSPQMYYLKFGEQKVIGASPELLFRLRQGEMETFPLAGTAKR 282
Cdd:PRK15465 200 VQEYLHSGDCYQVNLAQRFHATYSGDEWQAFLQLNQANRAPFSAFLRLEQGAILSLSPERFILCDNSEIQTRPIKGTLPR 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 283 GVDEKEDVALARALLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKVRSLMDIKRFSHVQHISSEIVGIIADDQDMFSALA 362
Cdd:PRK15465 280 LPDPQEDSKQAEKLANSAKDRAENLMIVDLMRNDIGRVAVAGSVKVPELFVVEPFPAVHHLVSTITARLPEQLHASDLLR 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 363 SNFPAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGQFSFNGDCHFAIPIRTVFAKGNKAYVQTCGGNVYDSNAEGEYEE 442
Cdd:PRK15465 360 AAFPGGSITGAPKVRAMEIIDELEPQRRNAWCGSIGYLSFCGNMDTSITIRTLTAINGQIYCSAGGGIVADSQEEAEYQE 439
|
410
....*....|....*
gi 943635177 443 iqrKFAGTKRVLDQF 457
Cdd:PRK15465 440 ---TFDKVNRILRQL 451
|
|
| PRK13564 |
PRK13564 |
anthranilate synthase component 1; |
116-442 |
7.32e-60 |
|
anthranilate synthase component 1;
Pssm-ID: 237428 [Multi-domain] Cd Length: 520 Bit Score: 204.30 E-value: 7.32e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 116 YDAMNYFEPTLNLQTSDMFDGFRFGLYKDGLILDKMTG----QVFYFYYD-------QDRSELVQSLLDAPVPENGSLVV 184
Cdd:PRK13564 152 YDLVAGFEPLPQLPAGNNCPDYCFYLAETLLVIDHQKKsarlQASLFTPDeeekqrlAARLAQLKQQLTQPAPPLPVTSV 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 185 TPAGE--SMTREEHAQAVAKVKQDIIDGKIFQteVGFKKWFDLE-GDTIAIYEQMRIVNPSPQMYYLKFGEQKVIGASPE 261
Cdd:PRK13564 232 PDMEVsvNISDEEFCAVVRKLKEHIRAGDIFQ--VVPSRRFSLPcPSPLAAYRVLKKSNPSPYMFYMQDEDFTLFGASPE 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 262 --LLFRLRQGEMETFPLAGTAKRGVDEkeDVALARALLN--------DPKEIAEHNMIVDLHRNDIGRVARFGTVKVRSL 331
Cdd:PRK13564 310 saLKYDASSRQVEIYPIAGTRPRGRRA--DGSIDRDLDSrielelrtDHKELAEHLMLVDLARNDLARICQPGSRYVADL 387
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 332 MDIKRFSHVQHISSEIVGIIADDQDMFSALASNFPAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGQFSFNGDCHFAIP 411
Cdd:PRK13564 388 LKVDRYSHVMHLVSRVVGELRHDLDALHAYRACMNMGTLTGAPKVRAMQLIREVEGQRRGSYGGAVGYLTGHGDLDTCIV 467
|
330 340 350
....*....|....*....|....*....|.
gi 943635177 412 IRTVFAKGNKAYVQTCGGNVYDSNAEGEYEE 442
Cdd:PRK13564 468 IRSAFVENGIATVQAGAGVVLDSDPQSEADE 498
|
|
| PRK05940 |
PRK05940 |
anthranilate synthase component I; |
41-442 |
2.11e-59 |
|
anthranilate synthase component I;
Pssm-ID: 235651 [Multi-domain] Cd Length: 463 Bit Score: 201.50 E-value: 2.11e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 41 MLES----LGEESYISRHSIIGFDPEKL-LW--AEGNTL-FIQErdgetasyesdnpyYLLRSIVPQNIISR-GYAGGLT 111
Cdd:PRK05940 36 LLESpyptPADYPPLSRYSICAGSPRKPrLWtpKLGEILpFLRQ--------------LLARSLDPSALPEHlPFTGGWL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 112 GYIGYD------AMNYFEP-TLNLQTSDMFDGFRFGlykdglILDKMTGQVFYFYYDQDRSELVQSLLDAPVPENGSLVV 184
Cdd:PRK05940 102 GWLGYDlaweieRLPHLNPdPLPFPVAYWYEPESFA------ILDHQEQILWLAASDPSQLDRLEQQLEQPTPEPDLPLD 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 185 TPAGES-----MTREEHAQAVAKVKQDIIDGKIFQTEVGFKKWFDLEGDTIAIYEQMRIVNPSPQMYYLK--FGEqkVIG 257
Cdd:PRK05940 176 LRTPPSslifyTTQQEYEAAVRQAKKYIQAGDIFQANLSLRFQTTTSADSWQIYRRLQQINPSPFASYWRtpWGD--VVS 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 258 ASPELLFRLRQGEMETFPLAGTAKRGVDEKEDVALARALLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKVRSLMDIKRF 337
Cdd:PRK05940 254 CSPERLVQLQGNQAQTRPIAGTRPRGKTPAEDQQLAEELLSNIKERAEHIMLVDLERNDLGRVCQWGSVEVDELLTIERY 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 338 SHVQHISSEIVGIIADDQDMFSALASNFPAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGQFSFNGDCHFAIPIRTVF- 416
Cdd:PRK05940 334 SHVIHLVSNVVGTLQPNRDAIDLIRALFPGGTITGCPKVRCMEIIEELEPVRRNLFYGSCGYLDQRGNLDLNILIRTLLy 413
|
410 420 430
....*....|....*....|....*....|
gi 943635177 417 ----AKGNKAYVQTCGGNVYDSNAEGEYEE 442
Cdd:PRK05940 414 tplsRGLSTIWGQVGAGIVADSDPEKEWLE 443
|
|
| PRK13567 |
PRK13567 |
anthranilate synthase component I; Provisional |
41-446 |
3.83e-58 |
|
anthranilate synthase component I; Provisional
Pssm-ID: 184148 [Multi-domain] Cd Length: 468 Bit Score: 198.44 E-value: 3.83e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 41 MLESLGEESYISRHSIIGFDPEKLLWAEGNTLFIQERDGETAsyESDNPYYLLRSIVPQ--NIISRGYAGGL---TGYIG 115
Cdd:PRK13567 26 ILESTNQQQTKGRYSVVIFDIYGTLTLDNDVLSVSTLKESYQ--ITERPYHYLTTKINEdyHNIQDEQLKSLpfiSGYVG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 116 ---YDAMNYFEPTL------NLQTSD-----MFDGFRFGLYKDGLILdkMTGQVFYFYYDQDRSELVQSLLDA-----PV 176
Cdd:PRK13567 104 tcsFDLVRHEFPKLqsiqleDHKQHDvrlymVEQVYVFDHYKDELYI--IATNQFSNSTKSDLENRVNKSIEDltkiqPF 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 177 PENGSLVVTPAG--ESMTREEHAQAVAKVKQDIIDGKIFQTE----VGFKKWF--DLEGDTIAIYEQMRIVNPSPQMYYL 248
Cdd:PRK13567 182 MPTQDFDFKTKEiqSNISEERFIEMIQYFKEKITEGDMFQVVpsriYKYAHHAsqHLNQLSFQLYQNLKRQNPSPYMYYL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 249 KFGEQKVIGASPELLFRLRQGEMETFPLAGTAKRGVDEKEDVALARALLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKV 328
Cdd:PRK13567 262 NIDQPYIVGSSPESFVSVKDQIVTTNPIAGTIQRGETTQIDNENMKQLLNDPKECSEHRMLVDLGRNDIHRVSKIGTSKI 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 329 RSLMDIKRFSHVQHISSEIVGIIADDQDMFSALASNFPAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGQFSFNGDCHF 408
Cdd:PRK13567 342 TKLMVIEKYEHVMHIVSEVTGKINQNLSPMTVIANLLPTGTVSGAPKLRAIERIYEQYPHKRGVYSGGVGYINCNHNLDF 421
|
410 420 430
....*....|....*....|....*....|....*...
gi 943635177 409 AIPIRTVFAKGNKAYVQTCGGNVYDSNAEGEYEEIQRK 446
Cdd:PRK13567 422 ALAIRTMMIDEQYINVEAGCGVVYDSIPEKELNETKLK 459
|
|
| MenF |
COG1169 |
Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites ... |
176-454 |
1.84e-45 |
|
Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; Isochorismate synthase EntC is part of the Pathway/BioSystem: Menaquinone biosynthesis
Pssm-ID: 440783 [Multi-domain] Cd Length: 353 Bit Score: 161.47 E-value: 1.84e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 176 VPEngSLVVTPAGESMTREEHAQAVAKVKQDIIDG---KIF---QTEVGFKKWFDLEgdtiAIYEQMRIVNPSPQMYYLK 249
Cdd:COG1169 73 LPR--LLLRRSRRGVPDPAEWREAVAQALEAIRAGeldKVVlarALDLTLDEPIDPR----ALLARLRRRNPDCYTFAVE 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 250 FGEQKV-IGASPELLFRLRQGEMETFPLAGTAKRGVDEKEDVALARALLNDPKEIAEHNMIVDlhrnDI-GRVARFG-TV 326
Cdd:COG1169 147 LGAGDGfVGASPERLVRRRGGQLTTEALAGTAPRGADPEEDAALAAALLASEKDRREHALVVD----SIrEALAPLCsSL 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 327 KVRSLMDIKRFSHVQHISSEIVGIIADDQDMFSALASNFPAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGQFSFNGDC 406
Cdd:COG1169 223 DVPEEPELLRLRNVQHLATPITGTLDPGVSALDLAAALHPTPAVGGTPREAALALIRELEPFDRGWYAGPVGWVDADGDG 302
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 943635177 407 HFAIPIRTVFAKGNKAYVQTCGGNVYDSNAEGEYEEIQRKFAGTKRVL 454
Cdd:COG1169 303 EFAVAIRSALIDGNRARLFAGAGIVAGSDPEAEWAETEAKLRTMLRAL 350
|
|
| isochor_syn |
TIGR00543 |
isochorismate synthases; This enzyme interconverts chorismate and isochorismate. In E. coli, ... |
170-454 |
2.16e-42 |
|
isochorismate synthases; This enzyme interconverts chorismate and isochorismate. In E. coli, different loci encode isochorismate synthases for the pathways of menaquinone biosynthesis and enterobactin biosynthesis (via salicilate) and fail to complement each other. Among isochorismate synthases, the N-terminal domain is poorly conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]
Pssm-ID: 273127 Cd Length: 351 Bit Score: 153.29 E-value: 2.16e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 170 SLLDAPVPENGSLVVTPA-GESMTREEHAQAVAKVKQDIIDG---KIF---QTEVGFKKWFDLegdtIAIYEQMRIVNPS 242
Cdd:TIGR00543 65 SSGIRPLRALPEQMTTLTtGEDPDKAAWRTAVEEALENIRQGpldKVVlarALTLKFADDIDP----IAVLANLRQQYPN 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 243 PQMYYLKFGEQKV-IGASPELLFRLRQGEMETFPLAGTAKRGVDEKEDVALARALLNDPKEIAEHNMIVDLHRNDIGRVA 321
Cdd:TIGR00543 141 AYIFLLEPPQGGVfLGATPERLLSREKGELLTEALAGTAPRSADPEEDRKLGELLLKDDKNLREHRLVVEYIRRRLQPIC 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 322 RfgTVKVRSLMDIKRFSHVQHISSEIVGIIADDQDMFSALASNFPAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGQFS 401
Cdd:TIGR00543 221 T--SLDVSETPELLKLANVQHLYTPISARLKDGDSLLDLLKQLHPTPAVGGLPREEALDFIREHEPFDRGLYAAPLGWLD 298
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 943635177 402 FNGDCHFAIPIRTVFAKGNKAYVQTCGGNVYDSNAEGEYEEIQRKFAGTKRVL 454
Cdd:TIGR00543 299 GEGNGEFAVGIRSALVEDGQVRLYAGAGIVADSDPESEWEETELKLQTMLRAL 351
|
|
| PRK13566 |
PRK13566 |
anthranilate synthase component I; |
186-446 |
3.99e-42 |
|
anthranilate synthase component I;
Pssm-ID: 237429 [Multi-domain] Cd Length: 720 Bit Score: 158.93 E-value: 3.99e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 186 PAGESMTREEHAQAVAKVKQDIIDGKIFQTEVGFKKWFDLEGDTIAIYEQMRIVNPSPQMYYLKFGEQK-VIGASPELLF 264
Cdd:PRK13566 236 PGFADHAPGEYAALVEKAKESFRRGDLFEVVPGQTFYEPCERSPSEIFRRLKEINPSPYGFFINLGDGEyLVGASPEMFV 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 265 RLRQGEMETFPLAGTAKRGVDEKEDVALARALLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKVRSLMDIKRFSHVQHIS 344
Cdd:PRK13566 316 RVEGRRVETCPISGTIKRGADAIGDAEQIRKLLNSKKDESELTMCTDVDRNDKSRVCEPGSVKVIGRRQIEMYSRLIHTV 395
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 345 SEIVGIIADDQDMFSALASNFPAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGQFSFNGDCHFAIPIRTVFAKGNKAYV 424
Cdd:PRK13566 396 DHVEGRLRPGFDALDAFLTHAWAVTVTGAPKLWAMQFIEDHERSPRRWYGGAVGMVGFDGDMNTGLTLRTIRIKDGVAEV 475
|
250 260
....*....|....*....|....*
gi 943635177 425 Q---TCggnVYDSNAEGEYEEIQRK 446
Cdd:PRK13566 476 RvgaTL---LFDSDPEAEEAETELK 497
|
|
| PLN02889 |
PLN02889 |
oxo-acid-lyase/anthranilate synthase |
192-443 |
5.29e-41 |
|
oxo-acid-lyase/anthranilate synthase
Pssm-ID: 215481 [Multi-domain] Cd Length: 918 Bit Score: 156.55 E-value: 5.29e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 192 TREEHAQAVAKVKQDIIDGKIFQ---TEVGFKKWFDLegDTIAIYEQMRIVNPSPQMYYLKFGEQK--VIGASPELLFRL 266
Cdd:PLN02889 642 SREQYIKDVQKCLKYIKDGESYElclTTQMRKRIGEI--DSLGLYLHLREKNPAPYAAWLNFSNENlcICSSSPERFLKL 719
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 267 -RQGEMETFPLAGTAKRGVDEKEDVALARALLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKVRSLMDIKRFSHVQHISS 345
Cdd:PLN02889 720 dRNGMLEAKPIKGTIARGSTPEEDEQLKLQLQYSEKDQAENLMIVDLLRNDLGRVCEPGSVHVPNLMDVESYTTVHTMVS 799
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 346 EIVGIIADDQDMFSALASNFPAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGQFSFNGDCHFAIPIRTVFAKGNKAYVQ 425
Cdd:PLN02889 800 TIRGKKRSNMSPVDCVRAAFPGGSMTGAPKLRSMELLDSLESSSRGIYSGSIGFFSYNQTFDLNIVIRTVVIHEGEASIG 879
|
250
....*....|....*...
gi 943635177 426 TCGGNVYDSNAEGEYEEI 443
Cdd:PLN02889 880 AGGAIVALSNPEDEYEEM 897
|
|
| PRK06404 |
PRK06404 |
anthranilate synthase component I; Reviewed |
242-446 |
3.49e-40 |
|
anthranilate synthase component I; Reviewed
Pssm-ID: 102361 [Multi-domain] Cd Length: 351 Bit Score: 147.32 E-value: 3.49e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 242 SPQMYYLKFGEQKVIGASPELLFRLRQGEMETFPLAGTAKRGVDEKEdvalaraLLNDPKEIAEHNMIVDLHRNDIGRVA 321
Cdd:PRK06404 151 SRYVFYYRFGKYRVVGSSPENVFTVNGNIINVDPIAGTYDDKILSNE-------LLNSEKDKLEHRMLLDLARNDLSKFA 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 322 RFGTVKVRSLMDIKRFSHVQHISSEIVGIIAdDQDMFSALASNFPAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGQFS 401
Cdd:PRK06404 224 DIGTLNVDKVMKIEEFSSVKHLVSQVTAKFS-NASYRDILASMFPAGTVSGSPKERAIEIINKYEETPRGPYGGAIGIIS 302
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 943635177 402 fNGDCHFAIPIRTVFAKGNKAYVQTCGGNVYDSNAEGEYEEIQRK 446
Cdd:PRK06404 303 -KGYTDMALVIRTAYSHGNGFRVRAGAGIVKDSDPEDEVNEIYSK 346
|
|
| PRK05877 |
PRK05877 |
aminodeoxychorismate synthase component I; Provisional |
161-461 |
4.81e-38 |
|
aminodeoxychorismate synthase component I; Provisional
Pssm-ID: 235634 [Multi-domain] Cd Length: 405 Bit Score: 142.92 E-value: 4.81e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 161 DQDRSELVQSLLDAPVPE--NGSLVVTPAG---------ESMTREEHAQAVAKVKQDIIDGKIFQTEVGFKKWFDLEGDT 229
Cdd:PRK05877 98 DRDGQWWYESLSGAPDPDwlASALATTRARpappcridwTPPDRAAHRDGVLACLEAIAAGEVYQACVCTQFTGTVTGSP 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 230 IAIY-EQMRIVNPSPQMYyLKFGEQKVIGASPELLFRLRQGEMETFPLAGTAKRGVDekedvalARALLNDPKEIAEHNM 308
Cdd:PRK05877 178 LDFFaDGVARTAPARAAY-LAGDWGAVASLSPELFLRRRGSVVTSSPIKGTLPLDAD-------PSALRASAKDVAENIM 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 309 IVDLHRNDIGRVARFGTVKVRSLMDIKRFSHVQHISSEIVGIIADDQDMFSALASNFPAGTLTGAPKIEAMKIIDDMEGD 388
Cdd:PRK05877 250 IVDLVRNDLGRVARTGTVTVPELLVVRPAPGVWHLVSTVSAQVPDELPMSDLLDATFPPASVTGTPKLRARELISQWEPV 329
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 943635177 389 GRGPYGGAVGQFSFNGDCHFAIPIRTV-FAKGNKAYVQTCGGNVYDSNAEGEYEEIQRKFAGTKRVLDQFAPAQ 461
Cdd:PRK05877 330 RRGIYCGTVGLASPVAGCELNVAIRTVeFDADGNAVLGVGGGITADSDPDAEWQECLHKAAPIVGLPAAATSAP 403
|
|
| salicyl_syn |
TIGR03494 |
salicylate synthase; Members of this protein family are salicylate synthases, bifunctional ... |
174-448 |
1.60e-36 |
|
salicylate synthase; Members of this protein family are salicylate synthases, bifunctional enzymes that make salicylate, in two steps, from chorismate. Members are homologous to anthranilate synthase component I from Trp biosynthesis. Members typically are found in gene regions associated with siderophore or other secondary metabolite biosynthesis.
Pssm-ID: 132533 [Multi-domain] Cd Length: 425 Bit Score: 139.14 E-value: 1.60e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 174 APVPENGSLVVTPAGESMtREEHAQAVAKVKQDIIDGKIFQTEVGFKKWFDLEgdtiAIYEQMRIVNPSPQMYYLKFGEQ 253
Cdd:TIGR03494 147 APLPQARAVDTATDPSAY-RARVARAVAEIAAGRYHKVILSRAVPLPFAIDFP----ATLLLGRRHNTPVRSFLLRLGGI 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 254 KVIGASPELLFRLRQ-GEMETFPLAGTAKRGVDEKEDVALARALLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKVRSLM 332
Cdd:TIGR03494 222 EALGFSPELVMSVRAdGKVVTEPLAGTRALGGGPEHDKQLRDELLSDSKEIVEHAISVKEAIEELEQVCEPGTVVVEDFM 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 333 DIKRFSHVQHISSEIVGIIADDQDMFSALASNFPAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGQFSFNGDCHFAIPI 412
Cdd:TIGR03494 302 TVRERGSVQHLGSTVSGQLAPSKDAWDAFEVLFPAITASGIPKAAALEAIMRLEKTPRGLYSGAVLLLDADGTLDAALVL 381
|
250 260 270
....*....|....*....|....*....|....*.
gi 943635177 413 RTVFAKGNKAYVQTCGGNVYDSNAEGEYEEIQRKFA 448
Cdd:TIGR03494 382 RAAYQDSGRTWLQAGAGIIAQSTPERELTETCEKLA 417
|
|
| PRK07093 |
PRK07093 |
para-aminobenzoate synthase component I; Validated |
191-446 |
1.58e-32 |
|
para-aminobenzoate synthase component I; Validated
Pssm-ID: 235932 [Multi-domain] Cd Length: 323 Bit Score: 125.75 E-value: 1.58e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 191 MTREEHAQAVAKVKQDIIDGK------IFQTEVgfKKWFDLEgdtiAIYEQmrivnpSPQMYYLKFGEQKVIgASPELLF 264
Cdd:PRK07093 71 ISFEEYQQGFELVQEEIQAGNsyllnlTYPTPI--ETNLSLE----EIFQA------SKAKYKLLFKDQFVC-FSPEPFV 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 265 RLRQGEMETFPLAGTAkrgvdekeDVALARA---LLNDPKEIAEHNMIVDLHRNDIGRVARfgTVKVrslmdiKRFSHVQ 341
Cdd:PRK07093 138 RIEDNKISTYPMKGTI--------DASLPNAeekLLNDEKEFAEHATIVDLLRNDLSMVAK--NVRV------TRFRYID 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 342 HI----------SSEIVGIIADD-----QDMFSALasnFPAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGqfSFNG-D 405
Cdd:PRK07093 202 KIktnkgeilqtSSEISGTLPENwqeniGDILAKL---LPAGSITGAPKEKTVEIIEQAEGYERGFYTGVFG--YFDGeS 276
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 943635177 406 CHFAIPIRTVFAKGNKAYVQTCGGNVYDSNAEGEYEEIQRK 446
Cdd:PRK07093 277 LDSAVMIRFIEQENDGLYFKSGGGITIDSDLKDEYNELIQK 317
|
|
| PRK07054 |
PRK07054 |
isochorismate synthase; |
234-456 |
9.56e-31 |
|
isochorismate synthase;
Pssm-ID: 235920 [Multi-domain] Cd Length: 475 Bit Score: 123.72 E-value: 9.56e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 234 EQMRIVNPSPQMYYLKFGEQKVIGASPELLFRLRQGEMETFPLAGTAKRGVDEKEDVALARALLNDPKEIAEHNMIVDLH 313
Cdd:PRK07054 237 RRLRLRDPHAHLFAFRRGNACFLGATPERLVRVAAGDLHTHALAGTIARGADPAEDARLGAALMASAKDRLEHALVVDAI 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 314 RNDIGRVARfgTVKVRSLMDIKRFSHVQHISSEIVGIIADDQDMFSALASNFPAGTLTGAPKIEAMKIIDDMEGDGRGPY 393
Cdd:PRK07054 317 RAALAPLSR--ALDIPDQPSLHRLPRLQHLSTPIRATLAPDATLLQVVAALHPTPAVGGHPRAAALDYIRAHEGFDRGWY 394
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 943635177 394 GGAVGQFSFNGDCHFAIPIRTVFAKGNKAYVQTCGGNVYDSNAEGEYEEIQRKFAGTKRVLDQ 456
Cdd:PRK07054 395 AAPIGWLDAHGNGDFAVALRSALITGGACRLFAGCGIVADSEPASEYRETCLKLSGMREALRA 457
|
|
| PRK07912 |
PRK07912 |
salicylate synthase; |
126-448 |
4.02e-28 |
|
salicylate synthase;
Pssm-ID: 169151 [Multi-domain] Cd Length: 449 Bit Score: 116.04 E-value: 4.02e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 126 LNLQTSDMFD--GFRFGLYKDGLI--LDKMT----------------GQVFYFYYDQDRSELVQSLLDAPVPE---NGSL 182
Cdd:PRK07912 98 LLLETDQAFGwvAFEFGVYRYGLQqrLAPGTplarvfsprtrivvteKGIRLFGAGIRHREAIDRLLATGVREvpqSRSV 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 183 VVTPAGeSMTREEHAQAVAKVK----QDIIDGKifQTEVGFKKwfdlegDTIAIYEQMRIVNPSPQMYYLKFGEQKVIGA 258
Cdd:PRK07912 178 DVSDDP-SGYRDRVAVAVAEIAagryHKVILSR--CVEVPFAV------DFPATYRLGRRHNTPVRSFLLRLGGIRALGY 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 259 SPELLFRLRQ-GEMETFPLAGTAKRGVDEKEDVaLARA-LLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKVRSLMDIKR 336
Cdd:PRK07912 249 SPELVTAVRAdGVVITEPLAGTRAFGRGAAIDR-LARDdLESNSKEIVEHAISVRSSLAEITEIAEPGSAAVIDFMTVRE 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 337 FSHVQHISSEIVGIIADDQDMFSALASNFPAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGQFSFNGDCHFAIPIRTVF 416
Cdd:PRK07912 328 RGSVQHLGSTVRGRLDASSDRMDALEALFPAVTASGIPKAAGVDAIFRLDEAPRGLYSGAVVMLSADGGLDAALTLRAAY 407
|
330 340 350
....*....|....*....|....*....|..
gi 943635177 417 AKGNKAYVQTCGGNVYDSNAEGEYEEIQRKFA 448
Cdd:PRK07912 408 QVGGRTWLRAGAGIIEESEPEREFEETCEKLS 439
|
|
| PRK06772 |
PRK06772 |
salicylate synthase; |
178-448 |
1.24e-22 |
|
salicylate synthase;
Pssm-ID: 102546 [Multi-domain] Cd Length: 434 Bit Score: 99.81 E-value: 1.24e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 178 ENGSLVVTPAgesMTREEHAQAVAKVKQDIIDGKIFQTEVGFKKWFDLEGDTIAIYEQMRIVNPSPQMYYLKFGEQKVIG 257
Cdd:PRK06772 160 QNAPLAVDTA---LNGEAYKQQVARAVAEIRRGEYVKVIVSRAIPLPSRIDMPATLLYGRQANTPVRSFMFRQEGREALG 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 258 ASPELLFRLRQGEMETFPLAGTAKRGVDEKEDVALARALLNDPKEIAEHNMIVDLHRNDIGRVARFGTVKVRSLMDIKRF 337
Cdd:PRK06772 237 FSPELVMSVTGNKVVTEPLAGTRDRMGNPEHNKAKEAELLHDSKEVLEHILSVKEAIAELEAVCQPGSVVVEDLMSVRQR 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 338 SHVQHISSEIVGIIADDQDMFSALASNFPAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGQFSfngDCHF--AIPIRTV 415
Cdd:PRK06772 317 GSVQHLGSGVSGQLAENKDAWDAFTVLFPSITASGIPKNAALNAIMQIEKTPRELYSGAILLLD---DTRFdaALVLRSV 393
|
250 260 270
....*....|....*....|....*....|...
gi 943635177 416 FAKGNKAYVQTCGGNVYDSNAEGEYEEIQRKFA 448
Cdd:PRK06772 394 FQDSQRCWIQAGAGIIAQSTPERELTETREKLA 426
|
|
| PLN02786 |
PLN02786 |
isochorismate synthase |
228-461 |
5.14e-19 |
|
isochorismate synthase
Pssm-ID: 178383 [Multi-domain] Cd Length: 533 Bit Score: 89.46 E-value: 5.14e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 228 DTIAIYEQMRIVNPSPQMYYLKF-GEQKVIGASPELLFRLRQGEMETFPLAGTAKRGVDEKEDVALARALLNDPKEIAEH 306
Cdd:PLN02786 298 DPIAWLACLQVEGQNAYQFCLQPpDAPAFIGNTPEQLFHRKGLGVCSEALAATRPRGGSSARDLQIELDLLTSPKDDLEF 377
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 307 NMIVDLHRNDIGRVARfgTVKVRSLMDIKRFSHVQHISSEIVGIIADDQDMFSALASNFPAGTLTGAPKIEAMKIIDDME 386
Cdd:PLN02786 378 SIVRENIREKLEAICD--RVVVEPHKAIRKLARVQHLYAQLAGRLRSEDDEFDILAALHPTPAVCGHPTEEARLLIAETE 455
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 943635177 387 GDGRGPYGGAVGQFSfNGDCHFAIPIRTVFA-KGNKAYVQTCGGNVYDSNAEGEYEEIQRK---FAGTKRVLDQFAPAQ 461
Cdd:PLN02786 456 SFDRGMYAGPVGWFG-GGESEFAVGIRSALVeKGLGALIYAGTGIVEGSNPSSEWNELELKisqFTKSLEHESALSPQN 533
|
|
| PRK06923 |
PRK06923 |
isochorismate synthase DhbC; Validated |
256-447 |
3.84e-14 |
|
isochorismate synthase DhbC; Validated
Pssm-ID: 235886 [Multi-domain] Cd Length: 399 Bit Score: 74.00 E-value: 3.84e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 256 IGASPELLFRLRQGEMETFPLAGTAKRGVDEKEDVALARALLNDPKEIAEHNMIVDlhrndigRVARFGTVKVRSLMDIK 335
Cdd:PRK06923 192 IGASPELLVSRHGMQVISNPLAGSRPRSDDPVEDKRRAEELLSSPKDLHEHAVVVE-------AVAAALRPYCHTLHVPE 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 336 RFSHVQ-----HISSEIVGIIADDQDMFSALASNF-PAGTLTGAPKIEAMKIIDDMEGDGRGPYGGAVGQFSFNGDCHFA 409
Cdd:PRK06923 265 KPSVIHteamwHLSTEVKGELKDPNTSSLELAIALhPTPAVCGTPTEEAREAIQQIEPFDREFFTGMLGWSDLNGDGEWI 344
|
170 180 190
....*....|....*....|....*....|....*...
gi 943635177 410 IPIRTVFAKGNKAYVQTCGGNVYDSNAEGEYEEIQRKF 447
Cdd:PRK06923 345 VTIRCAEVEENTLRLYAGAGVVAESKPEDELAETSAKF 382
|
|
| Anth_synt_I_N |
pfam04715 |
Anthranilate synthase component I, N terminal region; Anthranilate synthase (EC:4.1.3.27) ... |
38-156 |
3.92e-11 |
|
Anthranilate synthase component I, N terminal region; Anthranilate synthase (EC:4.1.3.27) catalyzes the first step in the biosynthesis of tryptophan. Component I catalyzes the formation of anthranilate using ammonia and chorismate. The catalytic site lies in the adjacent region, described in the chorismate binding enzyme family (pfam00425). This region is involved in feedback inhibition by tryptophan. This family also contains a region of Para-aminobenzoate synthase component I (EC 4.1.3.-).
Pssm-ID: 428082 [Multi-domain] Cd Length: 140 Bit Score: 60.79 E-value: 3.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 38 NCFMLESLGEESyiSRHSIIGFDPEKLLWAEGNTLFIQERDGETASYEsDNPYYLLR------SIVPQNIISRGYAGGLT 111
Cdd:pfam04715 17 HSFLLESAEGGE--GRYSFIGINPLLTIKSKNGEVSVSGPDGQELEQE-DGPLDALRallarfRIEDSPPTLPPFSGGLV 93
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 943635177 112 GYIGYDAMNYFE--PTLNLQTSDMFDgFRFGLYKDGLILDKMTGQVF 156
Cdd:pfam04715 94 GYLGYDLVRYIEklPRTAPDDLNLPD-ARLILYEDLIVFDHQENKLY 139
|
|
| PRK15016 |
PRK15016 |
isochorismate synthase EntC; Provisional |
228-442 |
2.06e-10 |
|
isochorismate synthase EntC; Provisional
Pssm-ID: 184977 [Multi-domain] Cd Length: 391 Bit Score: 62.20 E-value: 2.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 228 DTIAIYEQMRIVNPSPQMYYLKFGEQKVI-GASPELLFRLRQGEMETFPLAGTAKRGVDEKEDVALARALLNDPKEIAEH 306
Cdd:PRK15016 163 DSGALLERLIAQNPVSYNFHVPLADGGVLlGASPELLLRKDGERFSSLPLAGSARRQPDEVLDREAGNRLLASEKDRHEH 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 307 NMIVDLHRNDIGRvaRFGTVKVRSLMDIKRFSHVQHISSEIVGIIADDQDMFSALASNFPAGTLTGAPKIEAMKIIDDME 386
Cdd:PRK15016 243 ELVTQAMKEVLRE--RSSELHVPSSPQLITTPTLWHLATPFEGKANAQENALTLACLLHPTPALSGFPHQAAKQVIAELE 320
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 943635177 387 GDGRGPYGGAVGQFSFNGDCHFAIPIRTVFAKGNKAYVQTCGGNVYDSNAEGEYEE 442
Cdd:PRK15016 321 PFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRE 376
|
|
| PRK15012 |
PRK15012 |
menaquinone-specific isochorismate synthase; Provisional |
223-454 |
2.37e-10 |
|
menaquinone-specific isochorismate synthase; Provisional
Pssm-ID: 184974 [Multi-domain] Cd Length: 431 Bit Score: 62.17 E-value: 2.37e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 223 FDLEGDTIAIYEQMRIVNPSPQMYYLKF-GEQKVIGASPELLFRLRQGEMETFPLAGTAKRGVDEKEDVALARALLNDPK 301
Cdd:PRK15012 201 FASPVNAAAMMAASRRLNLNCYHFYMAFdAENAFLGSSPERLWRRRDKALRTEALAGTVANHPDDKQAQQLGEWLMADDK 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943635177 302 EIAEHNMIVDlhrnDIGRVARFGTVKVRSL-MDIKRFSHVQHISSEIVGII--ADDQDMFSALAsnfPAGTLTGAPKIEA 378
Cdd:PRK15012 281 NQRENMLVVE----DICQRLQADTQTLDVLpPQVLRLRKVQHLRRCIWTSLnkADDVICLHQLQ---PTAAVAGLPRDLA 353
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 943635177 379 MKIIDDMEGDGRGPYGGAVGQFSFNgDCHFAIPIRTVFAKGNKAYVQTCGGNVYDSNAEGEYEEIQRKFAGTKRVL 454
Cdd:PRK15012 354 RQFIARHEPFTREWYAGSAGYLSLQ-QSEFCVSLRSAKVSGNVVRLYAGAGIVRGSDPEQEWQEIDNKAAGLRTLL 428
|
|
| |
