|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
12-442 |
1.44e-139 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 406.85 E-value: 1.44e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 12 VFRVLLEFSIPFVIANVIQALYGAVDLLVIGKYCTPESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMNAKEEVR 91
Cdd:cd13138 1 ILKTLLLFALPLLLSNLLQQLYNLVDLLIVGQFLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 92 KTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSKRPMMFIA 171
Cdd:cd13138 81 KAVGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFVI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 172 LACVLNIVGDVVLTGILGMGVAGVAIATIGSQAVSMICAIWYLNRNQFIFTFRFANLKIDRDKALELAKVGIPISLQECM 251
Cdd:cd13138 161 IACVLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKLPFKLSLKDFRFDKEILKEILKIGLPSALQQSL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 252 VRLSFLYLTSVTNRLGVYAAAAVGVASKYDVFAMLPATSIANALAAITAQNYGAGKPERAKRSLTAGLAFAVAASAVFWL 331
Cdd:cd13138 241 VSISFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIIIL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 332 WAQVSPQTMIGIFSDNQDIIAAGIPFFTSCSYDYLAVSFVFCLNGYLNGRSKTIFTMISCCFGALALRMPLIWLVYSRWP 411
Cdd:cd13138 321 LVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAYLLSRLTG 400
|
410 420 430
....*....|....*....|....*....|.
gi 944163901 412 DNLFRIGTIAPLVSGFMACYTLIYVIYGFWK 442
Cdd:cd13138 401 LGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
7-405 |
4.27e-86 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 269.71 E-value: 4.27e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 7 LTEGNVFRVLLEFSIPFVIANVIQALYGAVDLLVIGKYcTPESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMNA 86
Cdd:COG0534 1 LTEGPILKLLLRLALPIILGNLLQSLYGLVDTIFVGRL-GTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 87 KEEVRKTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSKRP 166
Cdd:COG0534 80 REEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 167 MMFIALACVLNIVGDVVLTGILGMGVAGVAIATIGSQAVSMICAIWYLNRNQFIFTFRFANLKIDRDKALELAKVGIPIS 246
Cdd:COG0534 160 MIIMLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIGLPAG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 247 LQECMVRLSFLYLTSVTNRLGVYAAAAVGVASKYDVFAMLPATSIANALAAITAQNYGAGKPERAKRSLTAGLAFAVAAS 326
Cdd:COG0534 240 LQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIG 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 944163901 327 AVFWLWAQVSPQTMIGIFSDNQDIIAAGIPFFTSCSYDYLAVSFVFCLNGYLNGRSKTIFTMISCCFGALALRMPLIWL 405
Cdd:COG0534 320 LLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYL 398
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
14-442 |
2.82e-60 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 202.74 E-value: 2.82e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 14 RVLLEFSIPFVIANVIQALYGAVDLLVIGKYcTPESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMNAKEEVRKT 93
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRL-GAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 94 IGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSKRPMMFIALA 173
Cdd:cd13137 80 LGQSLLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 174 CVLNIVGDVVLT----GILGMGVAGVAIATIGSQAVSMICAIWYLNRNQFIFTFRFANLKIDRDKALELAKVGIPISLQE 249
Cdd:cd13137 160 NVLNIVLDYVLIfglwGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLPIKISFKGFRLDRKIIKKLLRIGLPAGLEQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 250 CMVRLSFLYLTSVTNRLGVYAAAAVGVASKYDVFAMLPATSIANALAAITAQNYGAGKPERAKRS--LTAGLAFAVAASA 327
Cdd:cd13137 240 LLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYgkRALRLGVLFMGLL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 328 VFWLWAQvsPQTMIGIFSDNQDIIAAGIPF--FTSCSYDYLAVSFVfcLNGYLNGRSKTIFTMISCCFGALALRMPLIWL 405
Cdd:cd13137 320 GLLLFIF--APPLASLFTPDPEVIELGVLYlrIVALSQPFLAISFV--LSGALRGAGDTRPPLIINLISMWLVRLPLAYL 395
|
410 420 430
....*....|....*....|....*....|....*..
gi 944163901 406 VYSRWPDNLFRIGTIAPLVSGFMACYTLIYVIYGFWK 442
Cdd:cd13137 396 LGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKWK 432
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
4-405 |
1.70e-58 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 198.57 E-value: 1.70e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 4 ENNLTEGNVFRVLLEFSIPFVIANVIQALYGAVDLLVIGKYcTPESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTG 83
Cdd:cd13142 1 RENILEGSILRTLLKLAWPIIVSNLLQVAYNLADTFWLGRL-GADAVAAPSISWPLIFLFISLGGGLTVAGTALVAQYTG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 84 MNAKEEVRKTIGTTLSIFGAAAVVLTVLMLFFT-PAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGD 162
Cdd:cd13142 80 AGDYDKANKVAGQTFSFVIILSLILAVLGYILSrPLLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 163 SKRPMMFIALACVLNIVGDVVL----TGILGMGVAGVAIATIGSQAVSMICAIWYLNRNQFIFTFRFANLKIDRDKALEL 238
Cdd:cd13142 160 TKTPMKIMFGSVLLNVILDPLLifgiGPFPGLGVAGAALATVISRGIAAVIGLYLLFKGRVGLKISLRDLKPDWEWLKKI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 239 AKVGIPISLQECMVRLSFLYLTSVTNRLGVYAAAAVGVASKYDVFAMLPATSIANALAAITAQNYGAGKPERAKRSLTAG 318
Cdd:cd13142 240 FRIGLPSSIEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 319 LAFAVAASAVFWLWAQVSPQTMIGIFSDNQDIIAAGIPFFTscsydYLAVSFVF-----CLNGYLNGRSKTIFTMISCCF 393
Cdd:cd13142 320 ALLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLR-----IVAPSFPFfglfqVINGAFRGSGHTLTAMIISIL 394
|
410
....*....|..
gi 944163901 394 GALALRMPLIWL 405
Cdd:cd13142 395 RLWVIRIPLAYL 406
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
11-378 |
1.25e-48 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 171.92 E-value: 1.25e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 11 NVFRVLLEFSIPFVIANVIQALYGAVDLLVIGKYCTPESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMNAKEEV 90
Cdd:cd13143 1 PIGKLFLKFALPAIIGMLVNGLYNIVDGIFVGHGVGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 91 RKTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSKRPMMFI 170
Cdd:cd13143 81 NRIFSTALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 171 ALACVLNIVGDVVLTGILGMGVAGVAIATIGSQAVSMICAIWYLNRNQFIFTFRFANLKIDRDKALELAKVGIPISLQEc 250
Cdd:cd13143 161 LIGAVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLRFKLSLKIIKEILALGFPSFLMQ- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 251 mvrLSFLYLTSVTNRLGVYAAAAVG-----VASKYDVFAMLPATSIANALAAITAQNYGAGKPERAKRSLTAGLAFAVAA 325
Cdd:cd13143 240 ---LSSSVVTIVLNLTLLGYGGDIGvaafgIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIY 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 944163901 326 SAVFWLWAQVSPQTMIGIFSDNQDIIAAGIPFFTSCSYDYLAVSFVFCLNGYL 378
Cdd:cd13143 317 GLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYF 369
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
16-359 |
1.24e-46 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 166.91 E-value: 1.24e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 16 LLEFSIPFVIANVIQALYGAVDLLVIGKYCTpESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMNAKEEVRKTIG 95
Cdd:cd13134 5 LFALAWPIFIELLLQMLLGTIDTFMLSRYSD-NAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIAG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 96 TTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSKRPMMFIALACV 175
Cdd:cd13134 84 VALLFNLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 176 LNIVGD-VVLTGILG---MGVAGVAIATIGSQAVSMICAIWYLNRNQFIFTFRFANLKIDRDKALELAKVGIPISLQECM 251
Cdd:cd13134 164 LNIVGNyLLIFGWFGlpkLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLKDLRPFPKKLLKKILKIGLPSAGEELS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 252 VRLSFLYLTSVTNRLGVYAAAAVGVASKYDVFAMLPATSIANALAAITAQNYGAGKPERA----KRSLTAGLAFAVAASA 327
Cdd:cd13134 244 YNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAykrvLKSLKIGLLVSLAVAL 323
|
330 340 350
....*....|....*....|....*....|..
gi 944163901 328 VFWLWAqvspQTMIGIFSDNQDIIAAGIPFFT 359
Cdd:cd13134 324 LLALFR----EPILGLFTDDPEIIALGKTLLL 351
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
20-405 |
1.31e-44 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 160.95 E-value: 1.31e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 20 SIPFVIANVIQALYGAVDLLVIGKYCTpESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMNAKEEVRKTIGTTLS 99
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLG-DALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 100 IFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSKRPMMFIALACVLNIV 179
Cdd:cd12082 80 LAILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 180 GDVVLTGILG---MGVAGVAIATIGSQAVSMICAIWYLNRNQFIFTFRFANLKIDRDKALELAKVGIPISLQECMVRLSF 256
Cdd:cd12082 160 LDPLLIFGLGppeLGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 257 LYLTSVTNRLGVYAAAAV-GVASKYDVFAMLPATSIANALAAITAQNYGAGKPERAKRSLTAGLAFAVAASAVFWLWAQV 335
Cdd:cd12082 240 LIIVAIVAAFGGAAALAAyTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILL 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 336 SPQTMIGIFSDNQDIIAAGIPFFTSCSYDYLAVSFVFCLNGYLNGRSKTIFTMISCCFGALALRMPLIWL 405
Cdd:cd12082 320 FPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYV 389
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
10-406 |
1.49e-38 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 144.59 E-value: 1.49e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 10 GNVFRVLLEFSIPFVIANVIQALYGAVDLLVIGKYCTpESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMNAKEE 89
Cdd:cd13140 1 GPILKTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGS-DAVAAVGTAGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 90 VRKTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEES-FELAKLYVIICSCGILFICGYNAISAILRGYGDSKRPMM 168
Cdd:cd13140 80 ARKYARNALQLNLLLGILYGLLLLLFAKPLIGFFNLGDAEvISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 169 FIALACVLNIVGDVVLTGILG----MGVAGVAIATIGSQAVSMICAIWYLNRNQFIFTFRFANLKIDRDKALELAKVGIP 244
Cdd:cd13140 160 INAIGLVLNIILDPLLIFGFGpfpaLGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRILKRPDRKYIKEILKLGLP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 245 ISLQECMVRLSFLYLTSVTNRLGVYAAAAVGVASKYDVFAMLPATSIANALAAITAQNYGAGKPERAKRSLTAGLAFAVA 324
Cdd:cd13140 240 VALQSILFALISMILARIIASFGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKIASA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 325 ASAVFWLWAQVSPQTMIGIFSDNQDIIAAGIpfftscsyDYL---AVSFVF-CL----NGYLNGRSKTIF-TMISCCFGa 395
Cdd:cd13140 320 IGLFATLLLFFFGEPLFSLFIPDPETIAIGV--------DYLrilGFSQLFmCLeittTGAFNGLGRTKPpAIISIVFN- 390
|
410
....*....|.
gi 944163901 396 lALRMPLIWLV 406
Cdd:cd13140 391 -GLRIPLALLL 400
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-405 |
5.18e-37 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 140.45 E-value: 5.18e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 9 EGNVFRVLLEFSIPFVIANVIQALYGAVDLLVIGKYCTpESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMNAKE 88
Cdd:cd13144 3 SGPVLRLLLTMSIPAMISMLFQALYNIVDSIFVARLGE-NALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 89 EVRKTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSKRPMM 168
Cdd:cd13144 82 EANKAANNGLLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 169 FIALACVLNIVGDVVL----TGILGMGVAGVAIATIGSQAVSMICAIWYLNRNQFIFTFRFANLKIDRDKALELAKVGIP 244
Cdd:cd13144 162 AQLIGAIINIILDPILifglFGFPAMGIAGAAIATVIGQILAMFLAFFFLLRKNKDVQPDLRLFRPSLRIIKEIYAVGLP 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 245 ISLQECMVRLSFLYLTSVTNRLGVYAAAAVGVASKYDVFAMLPATSIANALAAITAQNYGAGKPERAKRSLTAGLAFAVA 324
Cdd:cd13144 242 SIIMQAISSVMVFGLNKILAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILIAVV 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 325 ASAVFWLWAQVSPQTMIGIFSDNQDIIAAGIPFFTSCSYDYLAVSFVFCLNGYLNGRSKTIFTMISCCFGALALRMPLIW 404
Cdd:cd13144 322 IMLAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVLLPLAW 401
|
.
gi 944163901 405 L 405
Cdd:cd13144 402 L 402
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
6-420 |
6.21e-36 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 137.83 E-value: 6.21e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 6 NLTEGNVFRVLLEFSIPFVIANVIQALYGAVDLLVIGKYcTPESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMN 85
Cdd:cd13141 3 DLTQGSIPKHIISMALPIAIGMIIQTLYFLVDLYFVGQL-GDAALAGVSLAGNVMFFVMALTQVLNVGTAALVSHAVGRK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 86 AKEEVRKTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAK--LYVIICSCGILFIcgYNAISAILRGYGDS 163
Cdd:cd13141 82 DQGEANAVFNQSLLLAAVLGLVVLVLGYLFGRLYLETLAADAATVEAATtyLYWFIPSLALQFI--LTVLGAALRGTGIV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 164 KrPMMFI-ALACVLNIV-GDVVLTG---ILGMGVAGVAIATIGSQAVSMICAIWYLNRNQFIFTFRFANLKIDRDKALEL 238
Cdd:cd13141 160 K-PFMVIqILAVLLNIIlAPILITGwgtGRALGVAGAGLASSISVAIAVVLLLYYFLRLEKYLRLDLALWRPDLPTWKRL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 239 AKVGIPISLQecmVRLSFLYLTS---VTNRLGVYAAAAVGVASKYDVFAMLPATSIANALAAITAQNYGAGKPERAKRSL 315
Cdd:cd13141 239 LKIGLPSGGE---FLLTFVYMAViywALRPFGAAAQAGFGIGSRIMQSLFLPAMAIAFAAPAIAGQNFGAGNYDRVRETF 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 316 TAGLAFAVAASAVFWLWAQVSPQTMIGIFSDNQDIIAAGIPFFTSCSYDYLAVSFVFCLNGYLNGRSKTIFTMISCCFGA 395
Cdd:cd13141 316 RITAILTTALMLVLTLLCQLVPELLVTPFSDDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQALGNTWPSLLSSASRL 395
|
410 420
....*....|....*....|....*
gi 944163901 396 LALRMPLIWLvySRWPDnlFRIGTI 420
Cdd:cd13141 396 LTFALPVIWL--SAQPD--FRIEQI 416
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
6-438 |
1.21e-35 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 136.96 E-value: 1.21e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 6 NLTEGNVFRVLLEFSIPFVIANVIQALYGAVDLLVIGKYCTpESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMN 85
Cdd:cd13145 1 DLTKGPIPKLIRKLAIPASVGFFFNTMFNVVDTFFAGKIST-EALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 86 AKEEVRKTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSKR 165
Cdd:cd13145 80 DRRKARRYAAQGLSFGIILAILLTVIGLFAAPPLFRLLGAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 166 PMMFIALACVLNIVGDVVLT----GILGMGVAGVAIATIGSQAVSMICAIWYLNRNQFIFTFRFANLKIDRDKALELAKV 241
Cdd:cd13145 160 YRNFLIIGFFLNIILDPLFIfgggGIPAMGVSGIALATIISQFIGMFYLLYKVRKSGIISGCRLRDFIPRLDVYKEILKQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 242 GIPISLQECMVRLSFLYLTSVTNRLGVYAAAAVGVASKYDVFAMLPATSIANALAAITAQNYGAGKPERA----KRSLTA 317
Cdd:cd13145 240 GFPASLNMMTIGLGIFVITYFVGQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVretyKKALKY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 318 GLAFAVAASAVFWLwaqvSPQTMIGIFSDNQDIIAAGIPFFTSCSYDYLAVSFVFCLNGYLNGRSKTIFTMISCCFGALA 397
Cdd:cd13145 320 GFVIMVVATVFLLF----FAEPLMSLFTNDPAVIAIGAGYLRIDALIFYAYVVLFISVSVLQGLKRPIFALWIGLYRQLV 395
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 944163901 398 LRMPLIWLVYSRWPDNLFRIGTIAPLVSGFMACYTLIYVIY 438
Cdd:cd13145 396 GPALVFWLLVNVLGLGVTGIWWGIFTIVWSAAIIALLYTRR 436
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
13-410 |
9.95e-34 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 131.14 E-value: 9.95e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 13 FRVLLEFSIPFVIANVIQALYGAVDLLVIGKYCTPESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMNAKEEVRK 92
Cdd:cd13136 2 HREILALALPAILSNITVPLLGLVDTAVVGHLGSAAYLGAVALGTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEAIA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 93 TIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSKRPMMFIAL 172
Cdd:cd13136 82 LLVRALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQIV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 173 ACVLNIVGDVVLTGILGMGVAGVAIATIGSQAVSMICAIWYLNRNQFIFTFRFANLKIDRDKALELAKVGIPISLQECMV 252
Cdd:cd13136 162 GNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSRRLPSKAALKRLFKLNRDIFIRTLAL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 253 RLSFLYLTSVTNRLGVYAAAAVGVASKYDVFAMLPATSIANALAAITAQNYGAGKPERA----KRSLTAGLAFAVAASAV 328
Cdd:cd13136 242 LAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAArrvaRRLLQWGLGLGVLLALL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 329 FWLwaqvSPQTMIGIFSDNQDIIAAGIPFFTSCSYDYLAVSFVFCLNGYLNGRSKTIFTMIScCFGALALRMPLIWLVYS 408
Cdd:cd13136 322 FFL----GGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNS-MLVSLAVFLPLLFLLVP 396
|
..
gi 944163901 409 RW 410
Cdd:cd13136 397 LW 398
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
6-405 |
1.10e-32 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 128.58 E-value: 1.10e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 6 NLTEGNVFRVLLEFSIPFVIANVIQALYGAVDLLVIGKYCTPEsVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMN 85
Cdd:cd13149 1 KLTEGSIPRHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKE-LAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 86 AKEEVRKTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSKR 165
Cdd:cd13149 80 DRNKAKRLATDSLILSLLLSVIVSLLGLFTIPPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 166 PMMFIALACVLNIVGDVVLT----GILGMGVAGVAIATIGSQAVSMICAIWYLNRNQFIFTFRFANLKIDRDKALELAKV 241
Cdd:cd13149 160 PSLVMLGAALVNVILDPILIfgfgPIPGMGIAGAAIATVISRALGLGAALYFLHYHHRLIDFSEPSLKALFRSWKDILSI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 242 GIPISLQECMVRLSFLYLTSVTNRLGVYAAAAVGVASKYDVFAMLPATSIANALAAITAQNYGAGKPERAKRSLTAGLAF 321
Cdd:cd13149 240 GIPAALSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKF 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 322 AVAASAVFWLWAQVSPQTMIGIFSDNQDIIAAGIPFFTSCSYDYLAVSFVFCLNGYLNGRSKTIFTMISCCFGALALRMP 401
Cdd:cd13149 320 SLIYGAILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRVFLLYIP 399
|
....
gi 944163901 402 LIWL 405
Cdd:cd13149 400 LAYV 403
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
22-353 |
7.31e-32 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 124.28 E-value: 7.31e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 22 PFVIANVIQALYGAVDLLVIGKYcTPESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMNAKEEVRKTIGTTLSIF 101
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHL-GPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 102 GAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSKRPMMFIALACVLNIVGD 181
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 182 VVLT-GILG-MGVAGVAIATIGSQAVSMICAIWYLNRNQFIFTFRFANLKIDRDKALELAKVGIPISLQECMVRLSFLYL 259
Cdd:TIGR00797 160 YILIfGKFGfLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 260 TSVTNRLGVYAAAAVGVASKYDVFAMLPATSIANALAAITAQNYGAGKPERAKRSLTAGLAFAVAASAVFWLWAQVSPQT 339
Cdd:TIGR00797 240 ALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFREF 319
|
330
....*....|....
gi 944163901 340 MIGIFSDNQDIIAA 353
Cdd:TIGR00797 320 IARLFTNDPEVLEL 333
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
14-407 |
2.26e-31 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 124.95 E-value: 2.26e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 14 RVLLEFSIPFVIANVIQALYGAVDLLVIGKYcTPESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMNAKEEVRKT 93
Cdd:cd13133 5 REILKIALPLVLSMLSQTVMGFTDRAFLGRL-SEVALAASGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 94 IGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSKRPMMFIALA 173
Cdd:cd13133 84 LWQGLYFSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVM 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 174 CVLNIVGDVVLT-GILG---MGVAGVAIATIGSQAVSMICAIWYL----NRNQFIFtfrFANLKIDRDKALELAKVGIPI 245
Cdd:cd13133 164 VVVNIVLDYALIfGKLGfpaMGIAGAAIATVIAEAVSLLFFLLLLfrrkNRRRFGL---RRAWRFDRELLRRILRLGLPS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 246 SLQECMVRLSFLYLTSVTNRLGVYAAAAVGVASKYDVFAMLPATSIANALAAITAQNYGAGKPERAKRSLTAGLAFAVAA 325
Cdd:cd13133 241 GLQFFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 326 SAVFWLWAQVSPQTMIGIFSDNQD---IIAAGIPF--FTSCSYDYLAVSFVFClnGYLNGRSKTIFTMISCCFGALALRM 400
Cdd:cd13133 321 MLLLGILFLLFPELLLSIFTPGADfalIAELAVPLlrFVAAYILFDALALVFA--GALRGAGDTRFVMLAELIVAWLYLL 398
|
....*..
gi 944163901 401 PLIWLVY 407
Cdd:cd13133 399 PPAYLLV 405
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
14-315 |
1.35e-30 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 122.65 E-value: 1.35e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 14 RVLLEFSIPFVIANVIQALYGAVDLL-VIGkyCTPESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMNAKEEVRK 92
Cdd:cd13147 9 KAIIKLSIPMIIAMLLQTLYNLVDAIwVAG--LGADALAAIGFVFPLFMIIIGLGNGLGAGASSAISRRIGAKDKEGADN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 93 TIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTpEESFELAKLY-VIICSCGILFICGyNAISAILRGYGDSKRPMMFIA 171
Cdd:cd13147 87 AAVHSILLGLIISIILTIVLLPFLEPILVLMGA-GEVLDLAVDYgRIIFLGSIFLIFN-NVAYGILRGEGDTKRAMYAMV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 172 LACVLNIVGDVVLTGILGMGVAGVAIATIGSQA-VSMICAIWYLNRNQFIFTFRFANLKIDRDKALELAKVGIPISLQEC 250
Cdd:cd13147 165 AGSILNIILDPIFIYTLGLGIAGAAWATVISMLiSSLVLLYWFFVKKDTYVSLSLKNFKFDKKIVKDILKVGIPASLEQL 244
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 944163901 251 MVRLSFLYLTSVTNRLGVYAAAAVGVAS-KYDVFAMLPATSIANALAAITAQNYGAGKPERAKRSL 315
Cdd:cd13147 245 IMSVLMIILNLILVIVAGTDGVAVYTAGwRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAY 310
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
3-405 |
2.26e-29 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 119.25 E-value: 2.26e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 3 QENNLTEGNVFRVLLEFSIPFVIANVIQALYGAVDLLVIGKYcTPESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYT 82
Cdd:cd13139 3 KEQDFTSGSLNRAIFLLAIPMVLEMVMESLFAVVDLYFVSRL-GALAIATVGLTESVLTIVYSIAIGLSMAATALVARRI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 83 GMNAKEEVRKTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGD 162
Cdd:cd13139 82 GEKDPEGAGFAAVQAILLGVALSLILSILGYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 163 SKRPMMFIALACVLNIVGDVVLTGILG----MGVAGVAIATIGSQAVSMICAIWYLNRNQFIFTFRFANLKIDRDKALEL 238
Cdd:cd13139 162 AAIAMRSLWLANGLNIILDPLFIFGLGpipaMGVTGAAIATTIGRSIGVLYQLYHLFKGKGRIQIRRRHLKLDWAIIKKI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 239 AKVGIPISLQECMVRLSFLYLTSVTNRLGVYAAAAVGVASKYDVFAMLPATSIANALAAITAQNYGAGKPERAKRSLTAG 318
Cdd:cd13139 242 IKIAVGGILQFLIASSSWIFLVRIIAEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVWRA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 319 LAFAVAASAVFWLWAQVSPQTMIGIFSDNQDIIAAGIP--FFTSCSYDYLAVSFVfcLNGYLNGRSKTIFTMISCCFGAL 396
Cdd:cd13139 322 GKYNMVFLGIVSLVFFLFAEPLVSFFTTDPEVIAIAVEalRIISLGYIFYGYGMV--LSQAFNGAGDTKTPTLINLVGFW 399
|
....*....
gi 944163901 397 ALRMPLIWL 405
Cdd:cd13139 400 LFQIPLAYL 408
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
13-357 |
4.56e-26 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 109.51 E-value: 4.56e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 13 FRVLLEFSIPFVIANVIQALYGAVDLLVIGKYcTPESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMNAKEEVRK 92
Cdd:cd13131 2 LRALLRLALPILIAQLAQMAMGFVDTVMAGRL-GADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 93 TIGTTLsIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSKRPMMFIAL 172
Cdd:cd13131 81 AVRQGL-WLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 173 ACVLNIVGDVVLT-GILG---MGVAGVAIATIGSQAVSMICAIWYLNRN----QFIFTFRFAnlKIDRDKALELAKVGIP 244
Cdd:cd13131 160 ALVLNIPLNYVLIfGKFGlpaLGGAGAGLATAIVYWLMFLALAFYIRRHkrfrRYRLFARFW--RPDWARLKELLRLGLP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 245 ISLQ---E---------CMVRLSFLYL------TSVTNrlgvyaaaavgvaskydVFAMLPaTSIANALAAITAQNYGAG 306
Cdd:cd13131 238 IGLTiffEvslfaavalLMGRLGTTVLaahqiaLNFAS-----------------LLFMVP-LGISMAATVRVGFALGAG 299
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 944163901 307 KPERAKR----SLTAGLAFAVAASAVFWLWaqvsPQTMIGIFSDNQDIIAAGIPF 357
Cdd:cd13131 300 DPADARRaglvGLGLGVGFAALTALLLLLF----PEQIAGLYTNDPAVIALAASL 350
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-406 |
7.94e-26 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 109.03 E-value: 7.94e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 9 EGNVFRVLLEFSIPFVIANVIQALYGAVDLLVIGKY--CTPESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMNA 86
Cdd:cd13146 3 SGPISPLLIRLALPILIGQLFQLLYNITDTIWISMIdpSDPALVGGIGLVFPLGMIFLALGNGIQVGVSSLLARAIGAQR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 87 KEEVRKTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSKRP 166
Cdd:cd13146 83 AKELDQAADSGLALALLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYM 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 167 MMFIALACVLNIVGDVVLTGILGMGVAGVAIATIGSQAVSMICAIWYLNRNQFIFTFRFANLKIDRDKALELAKVGIPIS 246
Cdd:cd13146 163 MMAMLIGTVVNIVLDPILIFVFDMGVKGAALATVLAQAISLLYLLYVFLIGKSNVTIHIKLSNISSSVIVEILRVGLPQM 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 247 LQECMVRLSFLYLTSVTNRLGVYAAAAVGVASKYDVFAMLPATSIANALAAITAQNYGAGKPERAKRSLTAGLAFAVAAS 326
Cdd:cd13146 243 LLQLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVV 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 327 AVFWLWAQVSPQTMIGIFSDNQDIIAAGIPFFTSCSYDYLAVSFVFCLNGYLNGRSKTIFTMISCCFGALALRMPLIWLV 406
Cdd:cd13146 323 LVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLLTLIRHVFLSVPVVYLL 402
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-354 |
3.60e-23 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 101.19 E-value: 3.60e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 7 LTEGNVFRVLLEFSIPFVIANVIQALYGAVDLLVIGKYCTpESVAAVSTGTQVTqIITSMITGLTLGGTI--MVGKYTGM 84
Cdd:cd13148 5 LLTAPILPTLLRLALPNILALLVQTLVGLAETYFVGQLGT-DALAGVALVFPLL-MLTQMMSNGAMGGGVssAIARALGA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 85 NAKEEVRKTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSK 164
Cdd:cd13148 83 GDRERAEALVWHALVIALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGNMR 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 165 RPMMFIALACVLNIV--GDVVL--TGILGMGVAGVAIATIGSQAVSMICAIWYLNRNQFIFTFRFANLKIDRDKALELAK 240
Cdd:cd13148 163 VPALVTLVGAVVQIPlsPGLILgwGPLPRLGVAGAAVAAVLYYALAALVLLRYLASGRSRLRLRLRALRLERRLFRDILR 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 241 VGIPISLQECMVRLSFLYLTSVTNRLGVYAAAAVGVASKYDvFAMLP-ATSIANALAAITAQNYGAGKPERAKRSLTAGL 319
Cdd:cd13148 243 VGLLAALSPLQTNLTVLLLTGLVGRFGTAALAGYGIGSRLE-FLLIPlVFGLGAAMTAMVGMNIGAGQIARARRIAWTGA 321
|
330 340 350
....*....|....*....|....*....|....*
gi 944163901 320 AFAVAASAVFWLWAQVSPQTMIGIFSDNQDIIAAG 354
Cdd:cd13148 322 LMAAVLAGAIGLVLALFPELWLGLFTHDPAVLAAG 356
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
22-183 |
8.07e-20 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 86.08 E-value: 8.07e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 22 PFVIANVIQALYGAVDLLVIGKYcTPESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMNAKEEVRKTIGTTLSIF 101
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHL-GAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 102 GAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSKRPMMFIALACVLNIVGD 181
Cdd:pfam01554 80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 944163901 182 VV 183
Cdd:pfam01554 160 YL 161
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
16-357 |
8.50e-19 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 88.12 E-value: 8.50e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 16 LLEFSIPFVIANVIQALYGAVDLLVIGKyCTPESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMNAKEEVRKTIG 95
Cdd:cd13135 3 INHIAIPLILQNLVSQLQMLVDRAFLGR-ISIRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDYAI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 96 TTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSKRPMMFIALACV 175
Cdd:cd13135 82 SSIVYNSIIGVILFLLWLFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIKNL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 176 LNIVGDVVLT----GILGMGVAGVAIATIGSQAVSMICAIwYLNRNQFIFTFRFANLKIDRDK---ALELAKVGIPISLQ 248
Cdd:cd13135 162 LNVILDYVLIfgnfGFPRLGIIGAAIATTIANVLNLIILV-YLCRKIKKLTFKLSNTKVLKANirpYKFTIKLGLPLGGE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 249 ECMVRLSFLYLTSVTNRLGVYAAAAVGVASKYDVFAMLPATSIANALAAITAQNYGAGKPERAKRSLTAGLAFAVAASAV 328
Cdd:cd13135 241 EFLWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIYIA 320
|
330 340
....*....|....*....|....*....
gi 944163901 329 FWLWAQVSPQTMIGIFSDNQDIIAAGIPF 357
Cdd:cd13135 321 AAIVFLAFPYKILSLFTNDPELINYSIPY 349
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
12-213 |
9.04e-18 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 85.20 E-value: 9.04e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 12 VFRVLLEFSIPFVIANVIQALYGAVDLLVIGKYcTPESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMNAKEEVR 91
Cdd:COG0534 227 ILKRILRIGLPAGLQQLAESLGFLVLNALVARL-GTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRAR 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 92 KTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSKRPMMFIA 171
Cdd:COG0534 306 RAARLALLLALGIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISL 385
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 944163901 172 LACVLNIVGDVVLTGILGMGVAGVAIATIGSQAVSMICAIWY 213
Cdd:COG0534 386 LRLWLVRLPLAYLLAFLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
12-355 |
3.36e-16 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 80.42 E-value: 3.36e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 12 VFRVLLEFSIPFVIANVIQALYGAVDLLVIGKYCTPESVAAVSTGTQVTQIItsmitgltLGGTIMVGK--------YTG 83
Cdd:PRK09575 10 IYRTFWRYTIPSIAAMLVNGLYQIVDGIFIGHYVGAEGLAGINMAWPVIGII--------LGIGLMVGMgtgsllsiKRG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 84 MNAKEEVRKTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDS 163
Cdd:PRK09575 82 EGDLEKAKRILTTGLLLLLLLGPIVSVILFLFADDFLRAQGAEGRTLELALQYIQVLIWGCLFTLGAIALPFLLRNDESP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 164 KRPMMFIALACVLNIVGDVVLTGILGMGVAGVAIATIGSQAVSMICAIWYLNRNQFIFTFRFANLKIDRDKALELAKVGi 243
Cdd:PRK09575 162 NLATGLMVIGALINIVLDYLFIGWLDWGLTGAAIATALAQLVVTVLGLGYFFSSRANIRLTLKELRFNWSLAPKIVLLG- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 244 piSLQECMvrlsFLYLTSVT---NRLGVYAAAAVGVASkydvFAM---------LPATSIANALAAITAQNYGAGKPERA 311
Cdd:PRK09575 241 --SSSFFM----YLYGSFVValhNRLFMEYGSALTVGA----YAIvgylmvlyyLVAEGIAEGMQPPVSYYFGARQYDNI 310
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 944163901 312 KRSLTAGLAFAVAASAVFWLWAQVSPQTMIGIF-SDNQDIIAAGI 355
Cdd:PRK09575 311 KKLLKLAMKVTVLAGIAWVLLLNLFPETMIALFnSGDSELIAETI 355
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
11-211 |
1.47e-15 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 77.68 E-value: 1.47e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 11 NVFRVLLEFSIPFVIANVIQALYGAVDLLVIGKYCTPESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMNAKEEV 90
Cdd:COG2244 170 GLWGLVLKYSLPLLLSGLLGLLLTNLDRLLLGALLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREEL 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 91 RKTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEesFELAKLYVIICSCGILFICGYNAISAILRGYGDSKRPMMFI 170
Cdd:COG2244 250 RRLYRKALRLLLLLGLPLALGLALLAPPLLSLLFGPE--YAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIIS 327
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 944163901 171 ALACVLNIVGDVVLtgILGMGVAGVAIATIGSQAVSMICAI 211
Cdd:COG2244 328 LIGAVLNLVLNLLL--IPRYGLVGAAIATLLSYLVLLLLLL 366
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
11-215 |
6.79e-13 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 69.88 E-value: 6.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 11 NVFRVLLEFSIPFVIANVIQALYGAVDLLVIGKYCTPESVA---AVSTGTQVTQIITSMITGLTLggTIMVGKYTgmNAK 87
Cdd:cd13128 203 KLAKELLRFSIPLALSGIFSLIYTRIDTIMLGYFLGDAAVGiynAAYRIAELLLFIPSAISTALF--PRISELYK--NDK 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 88 EEVRKTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEesFELAKLYVIICSCGILFICGYNAISAILRGYGDSKRPM 167
Cdd:cd13128 279 DELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEE--YLPAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTL 356
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 944163901 168 MFIALACVLNIVGDVVLtgILGMGVAGVAIATIGSQAVSMICAIWYLN 215
Cdd:cd13128 357 KILLIGALLNVILNLLL--IPKYGIIGAAIATLISEFIIFILLLYLLK 402
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
11-202 |
3.57e-12 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 67.73 E-value: 3.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 11 NVFRVLLEFSIPFVIANVIQALYGAVDLLVIGKYCTPESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMNAKEEV 90
Cdd:cd12082 216 ELLRRLLRIGLPSAIQNSLLSLGLLIIVAIVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRA 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 91 RKTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSKRPMMFI 170
Cdd:cd12082 296 RRITWVALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVS 375
|
170 180 190
....*....|....*....|....*....|..
gi 944163901 171 ALACVLNIVGDVVLTGILGMGVAGVAIATIGS 202
Cdd:cd12082 376 LLSYWVVRLPLAYVLAYLGLGLYGIWLALVIS 407
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
10-216 |
1.49e-11 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 65.95 E-value: 1.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 10 GNVFRVLLEFSIPFVIANVIQALYGAVD------LLVIGKYCTPESVAA----VSTGTQVTQIITSMITGLTLGGTIMVG 79
Cdd:cd13124 220 KEILKELLSYAIPITLSSLILPLLQLIDsftvprRLQAAGLSESEATALygilTGRAQPLVQLPTVIATALSTSLVPAIS 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 80 KYTGMNAKEEVRKTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIicscGILFICGYNAISAILRG 159
Cdd:cd13124 300 EAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDSEGGLILQILAP----SILFLSLQQVTAAILQG 375
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 944163901 160 YGDSKRPMMFIALACVLNIVGDVVLTGILGMgvAGVAIATIGSQAVSMICAIWYLNR 216
Cdd:cd13124 376 LGKVKIPVINLLIGLLVKIVLNYVLIPIFGI--YGAAIATVIGFLVAALLNLRALKK 430
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
48-212 |
8.67e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 57.13 E-value: 8.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 48 ESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMNAKEEVRKTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPE 127
Cdd:cd13134 261 AALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLVSLAVALLLALFREPILGLFTDDP 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 128 ESFELAKlYVIICSCGILFICGYNAISA-ILRGYGDSKRPMMF---------IALACVLNIVgdvvltgiLGMGVAGVAI 197
Cdd:cd13134 341 EIIALGK-TLLLISILLEPGRAFNIVLIgSLRAAGDARFPVLIgiismwgisVPLAYLLGIV--------LGLGLLGVWI 411
|
170
....*....|....*
gi 944163901 198 ATIGSQAVSMICAIW 212
Cdd:cd13134 412 AFAADEWVRGIIMLW 426
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
58-226 |
4.35e-08 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 55.16 E-value: 4.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 58 QVTQIITSMITGLTLGGTI------MVGKYTGMNAKEEVRKTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLL--KTPEES 129
Cdd:COG0728 39 FVAFRIPNLLRRLFAEGALsaafvpVLAEALEKEGEEEARRFASRVLTLLLLVLLVLTLLGILFAPLLVKLLapGFDPEK 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 130 FELAKLYVIICSCGILFICGYNAISAILRGYGDSKRPMMFIALACVLNIVGDVVLTGILGMGVAGVAIATIGSQAVSMIC 209
Cdd:COG0728 119 FALAVALTRIMFPYILFIGLSALLGGVLNARGRFAAPALAPVLLNLVIIAGLLLLAPLFGPGIYALAWGVLLGGVLQLLI 198
|
170
....*....|....*..
gi 944163901 210 AIWYLNRNQFIFTFRFA 226
Cdd:COG0728 199 QLPALRRLGLRLRPRFD 215
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
87-225 |
1.15e-07 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 53.61 E-value: 1.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 87 KEEVRKTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLL--KTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSK 164
Cdd:cd13123 67 EEEARRFASRVLTLLLLVLLLLTLLGILFAPLLVKLLapGFSGDKFELAVALTRIMFPYLLFISLSALLGGILNAHGRFF 146
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 944163901 165 RPMMFIALACVLNIVGDVVLTGILGMGVAGVAIATIGSQAVSMICAIWYLNRNQFIFTFRF 225
Cdd:cd13123 147 APALAPVLLNLVIIAGLLLLAPLFDLGIYALAWGVLLGGVLQLLVQLPALRRLGFRFRPRL 207
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
244-405 |
1.45e-07 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 51.03 E-value: 1.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 244 PISLQECMVRLSFLYLTSVTNRLGVYAAAAVGVASKYDVFAMLPATSIANALAAITAQNYGAGKPERAKRSLTAGLAFAV 323
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 324 AASAVFWLWAQVSPQTMIGIFSDNQDIIAAGIPFFTSCSYDYLAVSFVFCLNGYLNGRSKTIFTMISCCFGALaLRMPLI 403
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLL-LNIPLN 159
|
..
gi 944163901 404 WL 405
Cdd:pfam01554 160 YL 161
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
14-319 |
6.91e-07 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 51.35 E-value: 6.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 14 RVLLEFSIPFVIANVIQALYGAVDLLVIGKYcTPESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMNAKEEVRKT 93
Cdd:PRK01766 12 RQLLALALPILLAQVAQTAMGFVDTVMAGGV-SATDLAAVAIGTSIWLPVILFGHGLLLALTPIVAQLNGAGRRERIAHQ 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 94 IGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAisaiLRGYGDS---KRPMMFI 170
Cdd:PRK01766 91 VRQGLWLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQV----LRSFIDGlgkTKPTMVI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 171 ALACVL-NIVGDVVLT-GILGM---GVAGVAIATIGSQAVSMICAIWYLNRNQFIFTFR-FANL-KIDRDKALELAKVGI 243
Cdd:PRK01766 167 GFLGLLiNIPLNYIFIyGKFGFpelGGVGCGVATAIVYWVMFLAMLIYIKRARRFRDFRlFKGLyKPDWAVIKRLLKLGL 246
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 944163901 244 PISLQECMVRLSFLYLTSVTNRLGVYAAAAVGVASKYDVFA-MLPaTSIANALAAITAQNYGAGKPERAKRSLTAGL 319
Cdd:PRK01766 247 PIGLAIFFEVSLFAVVTLLVSPLGTVTVAAHQIALNFSSLLfMLP-LSLAMALTIRVGFELGAGRTLDARQYAYIGL 322
|
|
| MATE_like_10 |
cd13125 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
25-243 |
9.19e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240530 [Multi-domain] Cd Length: 409 Bit Score: 51.00 E-value: 9.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 25 IANVIQALYGAVDLLVIGKYCTPESVAAVSTGTQVTQIITSMIT-GLTLGGTimvgKYTGMNA--KEEVRKTIGTTLSI- 100
Cdd:cd13125 8 ISTLIKILAGLIINKVVAVYLGPSGVALLGQLQNFVTILQTIAGgGINNGVV----KYTAEYKddEEKLARVWSTAFRIt 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 101 FGAAAVVLTVLMLFFTPAVLRLLKTPEESFelaklYVIICSCGILFICGYNAISAILRGYGDSKRpmmFIALACVLNIVG 180
Cdd:cd13125 84 LILSILGGLLLLLFSKPLSSLLFGDIDYSW-----VFILLGLALPLFALNNLLLAILNGLKEIKR---YALINIISSLIG 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 944163901 181 DVV-LTGILGMGVAGVAIATIGSQAVSMICAIWYLNRNQFiFTFRFANLKIDRDKALELAKVGI 243
Cdd:cd13125 156 LLVsVLLVYFYGLKGALLALVLNQSLIFLVTLIYSRKQPW-FKLKYLWGRLDKDIIKKLLKFSL 218
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
21-216 |
1.64e-06 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 50.15 E-value: 1.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 21 IPFVIANVIQALYGAVDLlVIGKYCTPESVAAVSTGTQVTQIITSMItGLTLGGTIM--VGKYTGMNAKEEVRKTIGTTL 98
Cdd:COG0728 229 LPALLGVSVSQINLLVDT-ILASFLPEGSVSALYYADRLYQLPLGLF-GVAIGTALLprLSRAAAAGDLEEFRRTLSRGL 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 99 SIFGAAAVVLTVLMLFFTPAVLRLL----KTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSKRPMMFIALAC 174
Cdd:COG0728 307 RLVLLLTLPAAVGLIVLAEPIVRLLfergAFTAEDTALTALALAAYALGLPAFALVKVLARAFYARQDTRTPVRIAVIAV 386
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 944163901 175 VLNIVGDVVLTGIlgMGVAGVAIATIGSQAVSMICAIWYLNR 216
Cdd:COG0728 387 VVNIVLNLLLVPP--LGHAGLALATSLSALVNALLLLVLLRR 426
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
21-216 |
1.98e-06 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 49.76 E-value: 1.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 21 IPFVIANVIQALYGAVDLlVIGKYCTPESVAAVSTGTQVTQIITSMItGLTLGGTIM--VGKYTGMNAKEEVRKTIGTTL 98
Cdd:cd13123 222 LPALLGVSVSQINLLVDT-ILASFLPEGSISALYYADRLYQLPLGIF-GVAIATALLprLSRLAAAGDLDEFRRTLSRGL 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 99 SIFGAAAVVLTVLMLFFTPAVLRLL----KTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSKRPMMFIALAC 174
Cdd:cd13123 300 RLVLFLLLPAAVGLIVLAEPIVRLLfergAFTAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIAVIAV 379
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 944163901 175 VLNIVGDVVLTGIlgMGVAGVAIATIGSQAVSMICAIWYLNR 216
Cdd:cd13123 380 AVNILLNLLLIKP--LGHVGLALATSLSAWVNALLLLVLLRR 419
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
16-216 |
2.25e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 49.61 E-value: 2.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 16 LLEFSIPFVIANVIQALYGAVDLLVIGKYcTPESVAAVSTGTQVTQIitSMITGLTLGGTI--MVGKYTGMNAKEEVRKT 93
Cdd:cd13149 236 ILSIGIPAALSNILTPLSAAFITALVATY-GPAAVAAFGVATRIESF--AFIIVMALSSALgpFVGQNWGAGQYERVQEG 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 94 IGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSKRPMMFIAL- 172
Cdd:cd13149 313 LKISLKFSLIYGAILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIr 392
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 944163901 173 ACVLNIvgDVVLTGILGMGVAGVAIATIGSQAVSMICAIWYLNR 216
Cdd:cd13149 393 VFLLYI--PLAYVGSHLLGFAGVFIGALAGNLIAGILAYFIAKK 434
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
47-218 |
2.59e-06 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 49.42 E-value: 2.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 47 PESVAAVSTGTQVTQIITsMIT-GLTLGGTIMVGKYTGMNAKEEVRKTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKT 125
Cdd:cd13131 261 TTVLAAHQIALNFASLLF-MVPlGISMAATVRVGFALGAGDPADARRAGLVGLGLGVGFAALTALLLLLFPEQIAGLYTN 339
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 126 PEESFELAKLYVIIcSCGILFICGYNAISA-ILRGYGDSKRPMmFIALAC--VLNIVGDVVLTGILGMGVAGVAIATIGS 202
Cdd:cd13131 340 DPAVIALAASLLVF-AALFQLFDGIQVVAAgALRGYKDTRVPF-LLALISywGIGLPLGYLLAFTTGLGAFGVWIGLIIG 417
|
170
....*....|....*.
gi 944163901 203 QAVSMICAIWYLNRNQ 218
Cdd:cd13131 418 LALAAILLLWRFRRLQ 433
|
|
| PRK10367 |
PRK10367 |
DNA-damage-inducible SOS response protein; Provisional |
14-305 |
8.31e-06 |
|
DNA-damage-inducible SOS response protein; Provisional
Pssm-ID: 182413 [Multi-domain] Cd Length: 441 Bit Score: 47.81 E-value: 8.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 14 RVLLEFSIPFVIANVIQALYGAVDLLVIGKYCTPESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMNAKEEVRKT 93
Cdd:PRK10367 9 KALWRLALPMIFSNITVPLLGLVDTAVIGHLDSPVYLGGVAVGATATSFLFMLLLFLRMSTTGLTAQAFGAKNPQALARA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 94 IGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVII------CSCGILFICGYnaisaiLRGYGDSKRPM 167
Cdd:PRK10367 89 LVQPLLLALGAGALIALLRTPLIDLALHIVGGSEAVLEQARRFLEIrwlsapASLANLVLLGW------LLGVQYARAPV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 168 MFIALACVLNIVGDVVLTGILGMGVAGVAIATIGSQAVSMICAIWYLNRNQFIFTFRFANLKID-RDKALELAKVGIPIS 246
Cdd:PRK10367 163 ILLVVGNILNIVLDLWLVMGLHMNVQGAALATVIAEYATLLIGLLMVRKVLKLRGISLEMLKTAwRGNFRRLLALNRDIM 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 944163901 247 LQECMVRLSFLYLTSVTNRLGVYAAAAVGVASKYDVFAMLPATSIANALAAITAQNYGA 305
Cdd:PRK10367 243 LRSLLLQLCFGAITVLGARLGSDIIAVNAVLMTLLTFTAYALDGFAYAVEAHSGQAYGA 301
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
13-218 |
8.41e-06 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 47.95 E-value: 8.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 13 FRVLLEFSIPFVIANVIQALYGAVDLLVIGKYCTPEsVAAVSTGTQVTQI-ITSMITGLTLGGTIMVGKYTGMNAKEEVR 91
Cdd:cd13132 2 AKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLE-LAAASLASSFANVtGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 92 KTIGTTLSIFGAAAVVLTVLmLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSKRPMMFIA 171
Cdd:cd13132 81 VYLQRALVILLLCCVPISLL-WLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISL 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 944163901 172 LACVLNIVGDVVLTGILGMGVAGVAIATIGSQ---AVSMICAIWYLNRNQ 218
Cdd:cd13132 160 VALLLNILLNYLLVFVLGLGFIGAALATSISYwliVVLLLLYIFFSKGHK 209
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
25-247 |
5.41e-05 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 45.23 E-value: 5.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 25 IANVIQALYGAVDLLVIGKYCTPESVAAVSTgTQVTQIITSMITGLTLGGTIMvgKYTGMNAKEEVRKTIGTTLSIFGAA 104
Cdd:cd13128 10 VGNIISKLLGFLVRVYLARYLGPEGFGILSL-ALAFVGLFSIFADLGLPTALV--REIARYRKEKIREIISTSLVLKLIL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 105 AVVLTVLMLFFTPavlrllkTPEESFELAKLYVIICSCGILFICGYNAISAILRGYGDSKRPMMFIALACVLNIVGDVVL 184
Cdd:cd13128 87 GILALLLLFLFAF-------LIAFYDPELVLLLYILALSLPFSALNSLFRGIFQGFEKMKYIVIARIIESVLSLILALIL 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 944163901 185 TgILGMGVAGVAIATIGSQAVSMICAIWYLNRNqfifTFRFANLKIDRDKALELAKVGIPISL 247
Cdd:cd13128 160 V-LLGGGLIGFALAYLIASVLSAILLLYIYRKK----ILLPKFFSFDLKLAKELLRFSIPLAL 217
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
141-216 |
8.56e-05 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 42.56 E-value: 8.56e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 944163901 141 SCGILFICGYNAISAILRGYGDSKRPMMFIALACVLNIVGDVVLtgILGMGVAGVAIATIGSQAVSMICAIWYLNR 216
Cdd:pfam14667 6 ALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNLLL--IPLFGIVGAAIATVISLLVVALLNLYYLRR 79
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
77-297 |
9.77e-05 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 44.38 E-value: 9.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 77 MVGKYTGMNAKEEVRKTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFelaklYVIIC-SCGILFIcgynAISA 155
Cdd:cd13124 58 LVAEYNALGDYKGARRIFRVSLILLLILGLVFFLLLFFGAPFLAQLLLGDPRLA-----PVIRAlAPAILIV----PLLS 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 156 ILRGYGDSKRPMMFIALACVL----NIVGDVVLTGIL-------GMGVAGVAIATIGSQAVSMICAIWYLNRNQFIFTFR 224
Cdd:cd13124 129 VLRGYFQGLQNMTPTAVSQVIeqivRVIVILVLAYLLlpvggglYYAAAGATFGAVIGALAGLLVLLYYYRKKRRELKRL 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 225 FANLKIDRDKALELAK----VGIPISLqeCMVRLSFLYLT---SVTNRLGVYAAAAVGVASKYDVFA-------MLPaTS 290
Cdd:cd13124 209 LRKSPRSKISTKEILKellsYAIPITL--SSLILPLLQLIdsfTVPRRLQAAGLSESEATALYGILTgraqplvQLP-TV 285
|
....*..
gi 944163901 291 IANALAA 297
Cdd:cd13124 286 IATALST 292
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
13-216 |
2.38e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 43.24 E-value: 2.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 13 FRVLLEFSIPFVIANVIQALYGAVDLLVIGKYCTPESVAAVSTGTQVTQIITSMITgltlgGTIMVGKYTGM----NAKE 88
Cdd:cd13127 198 LKELLSFGSKLLGSNLLNYFSRNLDNLIIGKFLGAAALGYYSRAYRLALLPVQNIT-----GPITRVLFPALsrlqDDPE 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 89 EVRKTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEesFELAKLYVIICSCGILFICGYNAISAILRGYGDSKRPMM 168
Cdd:cd13127 273 RLRRAYLKALRLLALITFPLMVGLALLAEPLVLLLLGEK--WLPAVPILQILALAGLFQPLSSLNGSLLLALGRTDLLLK 350
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 944163901 169 FIALACVLNIVgdVVLTGILGmGVAGVAIATIGSQAVSMICAIWYLNR 216
Cdd:cd13127 351 LGLIKAVLTVL--ALLIGIPY-GIIGVAIAYVIASLLSFPLNLYLAGR 395
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
77-217 |
2.73e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 39.90 E-value: 2.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 77 MVGKYTGMNAKEEVRKTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVIICSCGILFICGYNAISAI 156
Cdd:cd13139 301 LVGQNLGAGQPDRAEKSVWRAGKYNMVFLGIVSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQA 380
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 944163901 157 LRGYGDSKRPMMfIALAC--VLNIVGDVVLTGILGMGVAGVAIATIGSQAVSMICAIWYLNRN 217
Cdd:cd13139 381 FNGAGDTKTPTL-INLVGfwLFQIPLAYLLARHLNLGPKGVFIAIPIAETVLAIAAIILFRRG 442
|
|
| PRK10189 |
PRK10189 |
EmmdR/YeeO family multidrug/toxin efflux MATE transporter; |
13-251 |
4.15e-03 |
|
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
Pssm-ID: 182293 [Multi-domain] Cd Length: 478 Bit Score: 39.33 E-value: 4.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 13 FRVLLEFSIPFVIANVIQALYGAVD-LLV--IGKyctpESVAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMNAKEE 89
Cdd:PRK10189 28 WREITPLAVPIFIENLCVLLMGVLStFLVswLGK----EAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRR 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 90 VRKTIGTTLSIFGAAAVVLTVLMLFFTPAVLRLL--KTPEESFELAKLYVIicscgiLFICGYNAI------SAILRGYG 161
Cdd:PRK10189 104 ARAAARQSLVIMTLFAVLLAVLIHFFGEQIIDLVagDATPEVKALALTYLE------LTVWSYPAAaitligSGALRGAG 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 162 DSKRPMMFIALACVLNIV-GDVVLTGIL---GMGVAGVAIATIGSQAVSMICAIWYLN-------RNQFIFTFRFANLKI 230
Cdd:PRK10189 178 NTKIPLLINGGMNILNIIiSSILIYGLFswqGLGFVGAGLGLTISRYIGAVAIIWVLMigfnpalRISLKSYFKPLNFAI 257
|
250 260
....*....|....*....|.
gi 944163901 231 DRdkalELAKVGIPISLQECM 251
Cdd:PRK10189 258 IW----EVMGIGIPASIESVL 274
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
13-139 |
6.35e-03 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 38.77 E-value: 6.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944163901 13 FRVLLeFSIPFVIANVIQALYGAVDLlvigkyctpesvAAVSTGTQVTQIITSMITGLTLGGTIMVGKYTGMNAKEEVRK 92
Cdd:TIGR00797 227 FRVIL-ESLSFALLALLVARLGSIAL------------AAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKE 293
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 944163901 93 TIGTTLSIFGAAAVVLTVLMLFFTPAVLRLLKTPEESFELAKLYVII 139
Cdd:TIGR00797 294 VARVALKLSLLLGLVLAIILILFREFIARLFTNDPEVLELAAIYLIF 340
|
|
| |
