|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
3-263 |
9.07e-147 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 411.64 E-value: 9.07e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 3 RLVTFADGTTVPALGQGTWELGDDPAWRDEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGRRDEVFLVSKVRP 82
Cdd:cd19138 1 RTVTLPDGTKVPALGQGTWYMGEDPAKRAQEIEALRAGIDLGMTLIDTAEMYGDGGSEELVGEAIRGRRDKVFLVSKVLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 83 ENASEMKMMLACEKSLERLGVERLDLYLLHWEGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDIEGGEDCAA 162
Cdd:cd19138 81 SNASRQGTVRACERSLRRLGTDYLDLYLLHWRGGVPLAETVAAMEELKKEGKIRAWGVSNFDTDDMEELWAVPGGGNCAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 163 NQLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRGE-----LLEQPLIRDIANRHSASPAQVALAAVLRQDGVIAIPKA 237
Cdd:cd19138 161 NQVLYNLGSRGIEYDLLPWCREHGVPVMAYSPLAQGGllrrgLLENPTLKEIAARHGATPAQVALAWVLRDGNVIAIPKS 240
|
250 260
....*....|....*....|....*.
gi 946884465 238 SSVEHVEANADALDIQFDLEDLERLD 263
Cdd:cd19138 241 GSPEHARENAAAADLELTEEDLAELD 266
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
9-269 |
3.56e-110 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 318.92 E-value: 3.56e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 9 DGTTVPALGQGTWELGDDpawrdEEQQALARGIDLGMTLIDTAELYGdgrSERLVGEVIAG---RRDEVFLVSKVRPENA 85
Cdd:COG0656 1 NGVEIPALGLGTWQLPGE-----EAAAAVRTALEAGYRHIDTAAMYG---NEEGVGEAIAAsgvPREELFVTTKVWNDNH 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 86 SEMKMMLACEKSLERLGVERLDLYLLHWEGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDiEGGEDCAANQL 165
Cdd:COG0656 73 GYDDTLAAFEESLERLGLDYLDLYLIHWPGPGPYVETWRALEELYEEGLIRAIGVSNFDPEHLEELLA-ETGVKPAVNQV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 166 LYNLASRgvEFDLFPWMQARDMPMMAYSPLGRGELLEQPLIRDIANRHSASPAQVALAAVLRQdGVIAIPKASSVEHVEA 245
Cdd:COG0656 152 ELHPYLQ--QRELLAFCREHGIVVEAYSPLGRGKLLDDPVLAEIAEKHGKTPAQVVLRWHLQR-GVVVIPKSVTPERIRE 228
|
250 260 270
....*....|....*....|....*....|
gi 946884465 246 NADALDIQFDLEDLERLDAA------FPPP 269
Cdd:COG0656 229 NLDAFDFELSDEDMAAIDALdrgerlGPDP 258
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
10-263 |
1.62e-106 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 309.54 E-value: 1.62e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWELG----DDPAWRDEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGR-RDEVFLVSKVRPEN 84
Cdd:cd19072 1 GEEVPVLGLGTWGIGggmsKDYSDDKKAIEALRYAIELGINLIDTAEMYGGGHAEELVGKAIKGFdREDLFITTKVSPDH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 85 ASEMKMMLACEKSLERLGVERLDLYLLHWEGH-VPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDIEGGEDCAAN 163
Cdd:cd19072 81 LKYDDVIKAAKESLKRLGTDYIDLYLIHWPNPsIPIEETLRAMEELVEEGKIRYIGVSNFSLEELEEAQSYLKKGPIVAN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 164 QLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRGELL---EQPLIRDIANRHSASPAQVALAAVLRQDGVIAIPKASSV 240
Cdd:cd19072 161 QVEYNLFDREEESGLLPYCQKNGIAIIAYSPLEKGKLSnakGSPLLDEIAKKYGKTPAQIALNWLISKPNVIAIPKASNI 240
|
250 260
....*....|....*....|...
gi 946884465 241 EHVEANADALDIQFDLEDLERLD 263
Cdd:cd19072 241 EHLEENAGALGWELSEEDLQRLD 263
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
10-271 |
2.00e-80 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 245.09 E-value: 2.00e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWELGDDPAWRDEEQ--QALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGR-RDEVFLVSKV------ 80
Cdd:COG0667 10 GLKVSRLGLGTMTFGGPWGGVDEAEaiAILDAALDAGINFFDTADVYGPGRSEELLGEALKGRpRDDVVIATKVgrrmgp 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 81 --RPENASEMKMMLACEKSLERLGVERLDLYLLHW-EGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDI-EG 156
Cdd:COG0667 90 gpNGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRpDPDTPIEETLGALDELVREGKIRYIGVSNYSAEQLRRALAIaEG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 157 GEDCAANQLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRG-------------------------ELLEQPL-----I 206
Cdd:COG0667 170 LPPIVAVQNEYSLLDRSAEEELLPAARELGVGVLAYSPLAGGlltgkyrrgatfpegdraatnfvqgYLTERNLalvdaL 249
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 946884465 207 RDIANRHSASPAQVALAAVLRQDGVI-AIPKASSVEHVEANADALDIQFDLEDLERLDAAFPPPKH 271
Cdd:COG0667 250 RAIAAEHGVTPAQLALAWLLAQPGVTsVIPGARSPEQLEENLAAADLELSAEDLAALDAALAAVPA 315
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
13-263 |
3.77e-73 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 225.87 E-value: 3.77e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 13 VPALGQGTWELGDDPAWRDEEQQ---ALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGRRDEVFLVSKV--------- 80
Cdd:cd19084 4 VSRIGLGTWAIGGTWWGEVDDQEsieAIKAAIDLGINFFDTAPVYGFGHSEEILGKALKGRRDDVVIATKCglrwdggkg 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 81 RPENASEMKMMLACEKSLERLGVERLDLYLLHW-EGHVPLEETVEAFRDLVDEGMIARWGVSNLDLramEQLMDIEGGED 159
Cdd:cd19084 84 VTKDLSPESIRKEVEQSLRRLQTDYIDLYQIHWpDPNTPIEETAEALEKLKKEGKIRYIGVSNFSV---EQLEEARKYGP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 160 CAANQLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRG---------------------------------ELLEQplI 206
Cdd:cd19084 161 IVSLQPPYSMLEREIEEELLPYCRENGIGVLPYGPLAQGlltgkykkeptfppddrrsrfpffrgenfeknlEIVDK--L 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 946884465 207 RDIANRHSASPAQVALAAVLRQDGV-IAIPKASSVEHVEANADALDIQFDLEDLERLD 263
Cdd:cd19084 239 KEIAEKYGKSLAQLAIAWTLAQPGVtSAIVGAKNPEQLEENAGALDWELTEEELKEID 296
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
13-265 |
7.45e-73 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 225.16 E-value: 7.45e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 13 VPALGQGTWELGDDPAWRDEEQQ----ALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGRRDEVFLVSKVRPENASEM 88
Cdd:cd19085 1 VSRLGLGCWQFGGGYWWGDQDDEesiaTIHAALDAGINFFDTAEAYGDGHSEEVLGKALKGRRDDVVIATKVSPDNLTPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 89 KMMLACEKSLERLGVERLDLYLLHW-EGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDIegGEdCAANQLLY 167
Cdd:cd19085 81 DVRKSCERSLKRLGTDYIDLYQIHWpSSDVPLEETMEALEKLKEEGKIRAIGVSNFGPAQLEEALDA--GR-IDSNQLPY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 168 NLASRGVEFDLFPWMQARDMPMMAYSPLGRG----------------------------------ELLEqpLIRDIANRH 213
Cdd:cd19085 158 NLLWRAIEYEILPFCREHGIGVLAYSPLAQGlltgkfssaedfppgdartrlfrhfepgaeeetfEALE--KLKEIADEL 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 946884465 214 SASPAQVALAAVLRQDGVI-AIPKASSVEHVEANADALDIQFDLEDLERLDAA 265
Cdd:cd19085 236 GVTMAQLALAWVLQQPGVTsVIVGARNPEQLEENAAAVDLELSPSVLERLDEI 288
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
10-263 |
1.22e-67 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 210.89 E-value: 1.22e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWELG--DDPAW-RDEEQ-QALARGIDLGMTLIDTAELYGDGRSERLVGEVIAG-RRDEVFLVSKVRPEN 84
Cdd:cd19137 1 GEKIPALGLGTWGIGgfLTPDYsRDEEMvELLKTAIELGYTHIDTAEMYGGGHTEELVGKAIKDfPREDLFIVTKVWPTN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 85 ASEMKMMLACEKSLERLGVERLDLYLLHWEG-HVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDIeGGEDCAAN 163
Cdd:cd19137 81 LRYDDLLRSLQNSLRRLDTDYIDLYLIHWPNpNIPLEETLSAMAEGVRQGLIRYIGVSNFNRRLLEEAISK-SQTPIVCN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 164 QLLYNLASRG-VEFDLFPWMQARDMPMMAYSPLGRGELLEQPLIRDIANRHSASPAQVALAAVLRQDGVIAIPKASSVEH 242
Cdd:cd19137 160 QVKYNLEDRDpERDGLLEYCQKNGITVVAYSPLRRGLEKTNRTLEEIAKNYGKTIAQIALAWLIQKPNVVAIPKAGRVEH 239
|
250 260
....*....|....*....|.
gi 946884465 243 VEANADALDIQFDLEDLERLD 263
Cdd:cd19137 240 LKENLKATEIKLSEEEMKLLD 260
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
13-263 |
6.13e-66 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 205.58 E-value: 6.13e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 13 VPALGQGTWELGDDpawrdEEQQALARGIDLGMTLIDTAELYGDgrsERLVGEVIAG---RRDEVFLVSKVRPENASEMK 89
Cdd:cd19073 1 IPALGLGTWQLRGD-----DCANAVKEALELGYRHIDTAEIYNN---EAEVGEAIAEsgvPREDLFITTKVWRDHLRPED 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 90 MMLACEKSLERLGVERLDLYLLHWEGH-VPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDIeGGEDCAANQllyn 168
Cdd:cd19073 73 LKKSVDRSLEKLGTDYVDLLLIHWPNPtVPLEETLGALKELKEAGKVKSIGVSNFTIELLEEALDI-SPLPIAVNQ---- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 169 lasrgVEF-------DLFPWMQARDMPMMAYSPLGRGELLEQPLIRDIANRHSASPAQVALAAvLRQDGVIAIPKASSVE 241
Cdd:cd19073 148 -----VEFhpflyqaELLEYCRENDIVITAYSPLARGEVLRDPVIQEIAEKYDKTPAQVALRW-LVQKGIVVIPKASSED 221
|
250 260
....*....|....*....|..
gi 946884465 242 HVEANADALDIQFDLEDLERLD 263
Cdd:cd19073 222 HLKENLAIFDWELTSEDVAKID 243
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
16-265 |
2.01e-64 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 203.31 E-value: 2.01e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 16 LGQGTWELGDDPAW--RDEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGR---RDEVFLVSKVR------PEN 84
Cdd:pfam00248 1 IGLGTWQLGGGWGPisKEEALEALRAALEAGINFIDTAEVYGDGKSEELLGEALKDYpvkRDKVVIATKVPdgdgpwPSG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 85 ASEMKMMLACEKSLERLGVERLDLYLLHW-EGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDiEGGEDCAAN 163
Cdd:pfam00248 81 GSKENIRKSLEESLKRLGTDYIDLYYLHWpDPDTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKALT-KGKIPIVAV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 164 QLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRGELLEQ---------------------------PLIRDIANRHSAS 216
Cdd:pfam00248 160 QVEYNLLRRRQEEELLEYCKKNGIPLIAYSPLGGGLLTGKytrdpdkgpgerrrllkkgtplnlealEALEEIAKEHGVS 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 946884465 217 PAQVALAAVLRQDGV-IAIPKASSVEHVEANADALDIQFDLEDLERLDAA 265
Cdd:pfam00248 240 PAQVALRWALSKPGVtIPIPGASNPEQLEDNLGALEFPLSDEEVARIDEL 289
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
14-248 |
6.97e-64 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 200.05 E-value: 6.97e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 14 PALGQGTWELGDDPAwRDEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGR--RDEVFLVSKV--------RPE 83
Cdd:cd06660 1 SRLGLGTMTFGGDGD-EEEAFALLDAALEAGGNFFDTADVYGDGRSERLLGRWLKGRgnRDDVVIATKGghppggdpSRS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 84 NASEMKMMLACEKSLERLGVERLDLYLLHW-EGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDI---EGGED 159
Cdd:cd06660 80 RLSPEHIRRDLEESLRRLGTDYIDLYYLHRdDPSTPVEETLEALNELVREGKIRYIGVSNWSAERLAEALAYakaHGLPG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 160 CAANQLLYNLASRGV-EFDLFPWMQARDMPMMAYSPLGRGelleqplirdianrhsasPAQVALAAVLRQDGV-IAIPKA 237
Cdd:cd06660 160 FAAVQPQYSLLDRSPmEEELLDWAEENGLPLLAYSPLARG------------------PAQLALAWLLSQPFVtVPIVGA 221
|
250
....*....|.
gi 946884465 238 SSVEHVEANAD 248
Cdd:cd06660 222 RSPEQLEENLA 232
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
10-264 |
2.58e-63 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 199.41 E-value: 2.58e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWELGDDPAWRdeeqqALARGIDLGMTLIDTAELYGdgrSERLVGEVIAG---RRDEVFLVSKVRPENAS 86
Cdd:cd19140 5 GVRIPALGLGTYPLTGEECTR-----AVEHALELGYRHIDTAQMYG---NEAQVGEAIAAsgvPRDELFLTTKVWPDNYS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 87 EMKMMLACEKSLERLGVERLDLYLLHWEGH-VPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDIeGGEDCAANQl 165
Cdd:cd19140 77 PDDFLASVEESLRKLRTDYVDLLLLHWPNKdVPLAETLGALNEAQEAGLARHIGVSNFTVALLREAVEL-SEAPLFTNQ- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 166 lynlasrgVEF----DLFPWMQA---RDMPMMAYSPLGRGELLEQPLIRDIANRHSASPAQVALAAVLRQDGVIAIPKAS 238
Cdd:cd19140 155 --------VEYhpylDQRKLLDAareHGIALTAYSPLARGEVLKDPVLQEIGRKHGKTPAQVALRWLLQQEGVAAIPKAT 226
|
250 260
....*....|....*....|....*.
gi 946884465 239 SVEHVEANADALDIQFDLEDLERLDA 264
Cdd:cd19140 227 NPERLEENLDIFDFTLSDEEMARIAA 252
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
13-264 |
3.45e-63 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 198.73 E-value: 3.45e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 13 VPALGQGTWELGDDpAWRDEEQQALargiDLGMTLIDTAELYGDgrsERLVGEVIAG---RRDEVFLVSKVRPENASEMK 89
Cdd:cd19139 1 IPAFGLGTFRLKDD-VVIDSVRTAL----ELGYRHIDTAQIYDN---EAAVGQAIAEsgvPRDELFITTKIWIDNLSKDK 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 90 MMLACEKSLERLGVERLDLYLLHW---EGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDIEGGEDCAANQLL 166
Cdd:cd19139 73 LLPSLEESLEKLRTDYVDLTLIHWpspNDEVPVEEYIGALAEAKEQGLTRHIGVSNFTIALLDEAIAVVGAGAIATNQIE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 167 YN--LASRGvefdLFPWMQARDMPMMAYSPLGRGELLEQPLIRDIANRHSASPAQVALAAVLrQDGVIAIPKASSVEHVE 244
Cdd:cd19139 153 LSpyLQNRK----LVAHCKQHGIHVTSYMTLAYGKVLDDPVLAAIAERHGATPAQIALAWAM-ARGYAVIPSSTKREHLR 227
|
250 260
....*....|....*....|
gi 946884465 245 ANADALDIQFDLEDLERLDA 264
Cdd:cd19139 228 SNLLALDLTLDADDMAAIAA 247
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
13-263 |
3.83e-63 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 200.15 E-value: 3.83e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 13 VPALGQGTWELGDDPAW------RDEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGR--RDEVFLVSKVRPE- 83
Cdd:cd19093 2 VSPLGLGTWQWGDRLWWgygeygDEDLQAAFDAALEAGVNLFDTAEVYGTGRSERLLGRFLKELgdRDEVVIATKFAPLp 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 84 -NASEMKMMLACEKSLERLGVERLDLYLLHWEGHV--PLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDI--EGGE 158
Cdd:cd19093 82 wRLTRRSVVKALKASLERLGLDSIDLYQLHWPGPWysQIEALMDGLADAVEEGLVRAVGVSNYSADQLRRAHKAlkERGV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 159 DCAANQLLYNLASRGVEFD-LFPWMQARDMPMMAYSPLGRGEL----------------------LE--QPLI---RDIA 210
Cdd:cd19093 162 PLASNQVEYSLLYRDPEQNgLLPACDELGITLIAYSPLAQGLLtgkyspenpppggrrrlfgrknLEkvQPLLdalEEIA 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 946884465 211 NRHSASPAQVALAAVLRQdGVIAIPKASSVEHVEANADALDIQFDLEDLERLD 263
Cdd:cd19093 242 EKYGKTPAQVALNWLIAK-GVVPIPGAKNAEQAEENAGALGWRLSEEEVAELD 293
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
13-263 |
3.58e-60 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 191.16 E-value: 3.58e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 13 VPALGQGTWELGDDPAwrdeeQQALARGIDLGMTLIDTAELYGDgrsERLVGEVIAG---RRDEVFLVSKVRPENASEMK 89
Cdd:cd19071 1 MPLIGLGTYKLKPEET-----AEAVLAALEAGYRHIDTAAAYGN---EAEVGEAIREsgvPREELFITTKLWPTDHGYER 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 90 MMLACEKSLERLGVERLDLYLLHW-------EGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDiEGGEDCAA 162
Cdd:cd19071 73 VREALEESLKDLGLDYLDLYLIHWpvpgkegGSKEARLETWRALEELVDEGLVRSIGVSNFNVEHLEELLA-AARIKPAV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 163 NQllynlasrgVEF-------DLFPWMQARDMPMMAYSPLGRGE--LLEQPLIRDIANRHSASPAQVALAAVLrQDGVIA 233
Cdd:cd19071 152 NQ---------IELhpylqqkELVEFCKEHGIVVQAYSPLGRGRrpLLDDPVLKEIAKKYGKTPAQVLLRWAL-QRGVVV 221
|
250 260 270
....*....|....*....|....*....|
gi 946884465 234 IPKASSVEHVEANADALDIQFDLEDLERLD 263
Cdd:cd19071 222 IPKSSNPERIKENLDVFDFELSEEDMAAID 251
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
12-249 |
3.58e-55 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 178.05 E-value: 3.58e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 12 TVPALGQGTWELG-DDPAWRDEEQ--QALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGRRDEVFLVSKV-------- 80
Cdd:cd19086 2 EVSEIGFGTWGLGgDWWGDVDDAEaiRALRAALDLGINFFDTADVYGDGHSERLLGKALKGRRDKVVIATKFgnrfdggp 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 81 -RPENASEMKMMLACEKSLERLGVERLDLYLLH--WEGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDiegG 157
Cdd:cd19086 82 eRPQDFSPEYIREAVEASLKRLGTDYIDLYQLHnpPDEVLDNDELFEALEKLKQEGKIRAYGVSVGDPEEALAALR---R 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 158 EDCAANQLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRGELleqplirdianrhSASPAQVALAAVLRQDGV-IAIPK 236
Cdd:cd19086 159 GGIDVVQVIYNLLDQRPEEELFPLAEEHGVGVIARVPLASGLL-------------TGKLAQAALRFILSHPAVsTVIPG 225
|
250
....*....|...
gi 946884465 237 ASSVEHVEANADA 249
Cdd:cd19086 226 ARSPEQVEENAAA 238
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
10-264 |
1.80e-54 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 178.62 E-value: 1.80e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWELGDDPAWRDEEQQALARGI----DLGMTLIDTAELYGDGRSERLVGEVIAGRRDEVFLVSK------ 79
Cdd:cd19149 8 GIEASVIGLGTWAIGGGPWWGGSDDNESIRTIhaalDLGINLIDTAPAYGFGHSEEIVGKAIKGRRDKVVLATKcglrwd 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 80 --------------VRpENASEMKMMLACEKSLERLGVERLDLYLLHW-EGHVPLEETVEAFRDLVDEGMIARWGVSNLD 144
Cdd:cd19149 88 reggsfffvrdgvtVY-KNLSPESIREEVEQSLKRLGTDYIDLYQTHWqDVETPIEETMEALEELKRQGKIRAIGASNVS 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 145 LRAMEQLMdiEGGEdCAANQLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRG-------------------------- 198
Cdd:cd19149 167 VEQIKEYV--KAGQ-LDIIQEKYSMLDRGIEKELLPYCKKNNIAFQAYSPLEQGlltgkitpdrefdagdarsgipwfsp 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 946884465 199 -------ELLEQplIRDIANRHSASPAQVALAAVLRQDGVI-AIPKASSVEHVEANADALDIQFDLEDLERLDA 264
Cdd:cd19149 244 enrekvlALLEK--WKPLCEKYGCTLAQLVIAWTLAQPGITsALCGARKPEQAEENAKAGDIRLSAEDIATMRS 315
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
9-262 |
3.69e-54 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 177.41 E-value: 3.69e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 9 DGTTVPALGQGTWELGDDPAWRDEEQ--QALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGRRDEVFLVSKV------ 80
Cdd:cd19076 8 QGLEVSALGLGCMGMSAFYGPADEEEsiATLHRALELGVTFLDTADMYGPGTNEELLGKALKDRRDEVVIATKFgivrdp 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 81 ---------RPENASEmkmmlACEKSLERLGVERLDLYLLH-WEGHVPLEETVEAFRDLVDEGMIARWGVSNL---DLRA 147
Cdd:cd19076 88 gsgfrgvdgRPEYVRA-----ACEASLKRLGTDVIDLYYQHrVDPNVPIEETVGAMAELVEEGKVRYIGLSEAsadTIRR 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 148 MEQLMDIeggedcAANQLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRG----------------------------- 198
Cdd:cd19076 163 AHAVHPI------TAVQSEYSLWTRDIEDEVLPTCRELGIGFVAYSPLGRGfltgaikspedlpeddfrrnnprfqgenf 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 946884465 199 ----ELLEQplIRDIANRHSASPAQVALAAVLRQ-DGVIAIPKASSVEHVEANADALDIQFDLEDLERL 262
Cdd:cd19076 237 dknlKLVEK--LEAIAAEKGCTPAQLALAWVLAQgDDIVPIPGTKRIKYLEENVGALDVVLTPEELAEI 303
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
13-255 |
9.53e-54 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 175.10 E-value: 9.53e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 13 VPALGQGTWELGDDPAW---RDEEQ--QALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGRRDEVFLVSK---VRPE- 83
Cdd:cd19088 1 VSRLGYGAMRLTGPGIWgppADREEaiAVLRRALELGVNFIDTADSYGPDVNERLIAEALHPYPDDVVIATKgglVRTGp 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 84 -----NASEMKMMLACEKSLERLGVERLDLYLLHWEG-HVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDIegg 157
Cdd:cd19088 81 gwwgpDGSPEYLRQAVEASLRRLGLDRIDLYQLHRIDpKVPFEEQLGALAELQDEGLIRHIGLSNVTVAQIEEARAI--- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 158 EDCAANQLLYNLASRGVEfDLFPWMQARDMPMMAYSPLGRGELLEQ-PLIRDIANRHSASPAQVALAAVLRQ-DGVIAIP 235
Cdd:cd19088 158 VRIVSVQNRYNLANRDDE-GVLDYCEAAGIAFIPWFPLGGGDLAQPgGLLAEVAARLGATPAQVALAWLLARsPVMLPIP 236
|
250 260
....*....|....*....|
gi 946884465 236 KASSVEHVEANADALDIQFD 255
Cdd:cd19088 237 GTSSVEHLEENLAAAGLRLS 256
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
10-265 |
1.24e-51 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 171.26 E-value: 1.24e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWELGDDPAWR--------DEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGRRDEVFLVSKVR 81
Cdd:cd19091 10 GLKVSELALGTMTFGGGGGFFgawggvdqEEADRLVDIALDAGINFFDTADVYSEGESEEILGKALKGRRDDVLIATKVR 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 82 ---PEN-----ASEMKMMLACEKSLERLGVERLDLYLLH-WEGHVPLEETVEAFRDLVDEGMIARWGVSNLdlrAMEQLM 152
Cdd:cd19091 90 grmGEGpndvgLSRHHIIRAVEASLKRLGTDYIDLYQLHgFDALTPLEETLRALDDLVRQGKVRYIGVSNF---SAWQIM 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 153 ------DIEGGEDCAANQLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRGELL-----EQPL---------------- 205
Cdd:cd19091 167 kalgisERRGLARFVALQAYYSLLGRDLEHELMPLALDQGVGLLVWSPLAGGLLSgkyrrGQPApegsrlrrtgfdfppv 246
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 946884465 206 -----------IRDIANRHSASPAQVALAAVLRQDGV-IAIPKASSVEHVEANADALDIQFDLEDLERLDAA 265
Cdd:cd19091 247 drergydvvdaLREIAKETGATPAQVALAWLLSRPTVsSVIIGARNEEQLEDNLGAAGLSLTPEEIARLDKV 318
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
10-267 |
1.48e-51 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 170.83 E-value: 1.48e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWELGDDpAWRDEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGRRDEVFLVSKV------RPE 83
Cdd:cd19087 10 GLKVSRLCLGTMNFGGR-TDEETSFAIMDRALDAGINFFDTADVYGGGRSEEIIGRWIAGRRDDIVLATKVfgpmgdDPN 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 84 N--ASEMKMMLACEKSLERLGVERLDLYLLH-WEGHVPLEETVEAFRDLVDEGMIARWGVSN---------LDLRAMEQL 151
Cdd:cd19087 89 DrgLSRRHIRRAVEASLRRLQTDYIDLYQMHhFDRDTPLEETLRALDDLVRQGKIRYIGVSNfaawqiakaQGIAARRGL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 152 MDIEggedcaANQLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRG------------------------ELLEQPLIR 207
Cdd:cd19087 169 LRFV------SEQPMYNLLKRQAELEILPAARAYGLGVIPYSPLAGGlltgkygkgkrpesgrlveraryqARYGLEEYR 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 946884465 208 DIANRHSA-------SPAQVALAAVLRQDGVIA-IPKASSVEHVEANADALDIQFDLEDLERLDAAFP 267
Cdd:cd19087 243 DIAERFEAlaaeaglTPASLALAWVLSHPAVTSpIIGPRTLEQLEDSLAALEITLTPELLAEIDELFP 310
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
10-263 |
1.67e-51 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 170.84 E-value: 1.67e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWELGDdPAWR----DEEQ--QALARGIDLGMTLIDTAELYGDGRSERLVGEVIA--GRRDEVFLVSKVR 81
Cdd:cd19079 9 GLKVSRLCLGCMSFGD-PKWRpwvlDEEEsrPIIKRALDLGINFFDTANVYSGGASEEILGRALKefAPRDEVVIATKVY 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 82 PENASEMKM--------MLACEKSLERLGVERLDLYLLH-WEGHVPLEETVEAFRDLVDEGMIARWGVSNL---DLRAME 149
Cdd:cd19079 88 FPMGDGPNGrglsrkhiMAEVDASLKRLGTDYIDLYQIHrWDYETPIEETLEALHDVVKSGKVRYIGASSMyawQFAKAL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 150 QLMDIEGGEDCAANQLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRG----------ELLEQPL-------------- 205
Cdd:cd19079 168 HLAEKNGWTKFVSMQNHYNLLYREEEREMIPLCEEEGIGVIPWSPLARGrlarpwgdttERRRSTTdtaklkydyftead 247
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 946884465 206 ------IRDIANRHSASPAQVALAAVLRQDGVIA-IPKASSVEHVEANADALDIQFDLEDLERLD 263
Cdd:cd19079 248 keivdrVEEVAKERGVSMAQVALAWLLSKPGVTApIVGATKLEHLEDAVAALDIKLSEEEIKYLE 312
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
15-265 |
1.13e-50 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 168.62 E-value: 1.13e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 15 ALGQGTWELGDDPAWRDEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGRRDEVFLVSKVRPENASEMK----- 89
Cdd:cd19102 10 AIGGGGWGGGWGPQDDRDSIAAIRAALDLGINWIDTAAVYGLGHSEEVVGRALKGLRDRPIVATKCGLLWDEEGRirrsl 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 90 ----MMLACEKSLERLGVERLDLYLLHW-EGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDIEGgedCAANQ 164
Cdd:cd19102 90 kpasIRAECEASLRRLGVDVIDLYQIHWpDPDEPIEEAWGALAELKEEGKVRAIGVSNFSVDQMKRCQAIHP---IASLQ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 165 LLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRGEL----------------------------LEQPL-----IRDIAN 211
Cdd:cd19102 167 PPYSLLRRGIEAEILPFCAEHGIGVIVYSPMQSGLLtgkmtpervaslpaddwrrrspffqepnLARNLalvdaLRPIAE 246
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 946884465 212 RHSASPAQVALAAVLRQDGVI-AIPKASSVEHVEANADALDIQFDLEDLERLDAA 265
Cdd:cd19102 247 RHGRTVAQLAIAWVLRRPEVTsAIVGARRPDQIDETVGAADLRLTPEELAEIEAL 301
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
14-264 |
3.05e-50 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 166.27 E-value: 3.05e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 14 PALGQGTWELGDDpawrDEEQQALARGIDLGMTLIDTAELYgdgRSERLVGEVIAG-------RRDEVFLVSKVRPENAS 86
Cdd:cd19136 2 PILGLGTFRLRGE----EEVRQAVDAALKAGYRLIDTASVY---RNEADIGKALRDllpkyglSREDIFITSKLAPKDQG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 87 EMKMMLACEKSLERLGVERLDLYLLHWEG----------HVPLE-ETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMdie 155
Cdd:cd19136 75 YEKARAACLGSLERLGTDYLDLYLIHWPGvqglkpsdprNAELRrESWRALEDLYKEGKLRAIGVSNYTVRHLEELL--- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 156 ggEDC----AANQllynlasrgVEF-------DLFPWMQARDMPMMAYSPLGRGEL--LEQPLIRDIANRHSASPAQVAL 222
Cdd:cd19136 152 --KYCevppAVNQ---------VEFhphlvqkELLKFCKDHGIHLQAYSSLGSGDLrlLEDPTVLAIAKKYGRTPAQVLL 220
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 946884465 223 AAVLrQDGVIAIPKASSVEHVEANADALDIQFDLEDLERLDA 264
Cdd:cd19136 221 RWAL-QQGIGVIPKSTNPERIAENIKVFDFELSEEDMAELNA 261
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
1-264 |
6.71e-48 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 160.18 E-value: 6.71e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 1 MTRLVTFADGTTVPALGQGTWELGDdpawrdEEQQALARGI-DLGMTLIDTAELYGdgrSERLVGEVIAG---RRDEVFL 76
Cdd:cd19135 1 GTPTVRLSNGVEMPILGLGTSHSGG------YSHEAVVYALkECGYRHIDTAKRYG---CEELLGKAIKEsgvPREDLFL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 77 VSKVRPENASEMKMMLACEKSLERLGVERLDLYLLHWEG-HVP-------LEETVEAFRDLVDEGMIARWGVSNLDLRAM 148
Cdd:cd19135 72 TTKLWPSDYGYESTKQAFEASLKRLGVDYLDLYLLHWPDcPSSgknvketRAETWRALEELYDEGLCRAIGVSNFLIEHL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 149 EQLMdieggEDCA----ANQLLYNLASRGVEfdLFPWMQARDMPMMAYSPLGRGELLEQPLIRDIANRHSASPAQVALAA 224
Cdd:cd19135 152 EQLL-----EDCSvvphVNQVEFHPFQNPVE--LIEYCRDNNIVFEGYCPLAKGKALEEPTVTELAKKYQKTPAQILIRW 224
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 946884465 225 VLrQDGVIAIPKASSVEHVEANADALDIQFDLEDLERLDA 264
Cdd:cd19135 225 SI-QNGVVTIPKSTKEERIKENCQVFDFSLSEEDMATLDS 263
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
12-264 |
9.42e-48 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 159.80 E-value: 9.42e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 12 TVPALGQGTWELGDDPAwRDEEQQALargiDLGMTLIDTAELYGDgrsERLVGEVIAG---RRDEVFLVSKVRPENASEM 88
Cdd:PRK11172 2 SIPAFGLGTFRLKDQVV-IDSVKTAL----ELGYRAIDTAQIYDN---EAAVGQAIAEsgvPRDELFITTKIWIDNLAKD 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 89 KMMLACEKSLERLGVERLDLYLLHW---EGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDIEGGEDCAANQL 165
Cdd:PRK11172 74 KLIPSLKESLQKLRTDYVDLTLIHWpspNDEVSVEEFMQALLEAKKQGLTREIGISNFTIALMKQAIAAVGAENIATNQI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 166 -----LYNLAsrgvefdLFPWMQARDMPMMAYSPLGRGELLEQPLIRDIANRHSASPAQVALAAVLrQDGVIAIPKASSV 240
Cdd:PRK11172 154 elspyLQNRK-------VVAFAKEHGIHVTSYMTLAYGKVLKDPVIARIAAKHNATPAQVILAWAM-QLGYSVIPSSTKR 225
|
250 260
....*....|....*....|....
gi 946884465 241 EHVEANADALDIQFDLEDLERLDA 264
Cdd:PRK11172 226 ENLASNLLAQDLQLDAEDMAAIAA 249
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
4-262 |
2.28e-47 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 158.69 E-value: 2.28e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 4 LVTFADGTTVPALGQGTWELGDDpawrdEEQQALARGIDLGMTLIDTAELYGDgrsERLVGEVIAG---RRDEVFLVSKV 80
Cdd:cd19131 1 TITLNDGNTIPQLGLGVWQVSND-----EAASAVREALEVGYRSIDTAAIYGN---EEGVGKAIRAsgvPREELFITTKL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 81 RPENASEMKMMLACEKSLERLGVERLDLYLLHWEghVPLEET-VEAFRDLVD---EGMIARWGVSNLDLRAMEQLMDiEG 156
Cdd:cd19131 73 WNSDQGYDSTLRAFDESLRKLGLDYVDLYLIHWP--VPAQDKyVETWKALIElkkEGRVKSIGVSNFTIEHLQRLID-ET 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 157 GEDCAANQLlyNLASRGVEFDLFPWMQARDMPMMAYSPLGRGELLEQPLIRDIANRHSASPAQValaaVLR---QDGVIA 233
Cdd:cd19131 150 GVVPVVNQI--ELHPRFQQRELRAFHAKHGIQTESWSPLGQGGLLSDPVIGEIAEKHGKTPAQV----VIRwhlQNGLVV 223
|
250 260
....*....|....*....|....*....
gi 946884465 234 IPKASSVEHVEANADALDIQFDLEDLERL 262
Cdd:cd19131 224 IPKSVTPSRIAENFDVFDFELDADDMQAI 252
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
15-263 |
8.44e-47 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 158.54 E-value: 8.44e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 15 ALGQGTweLGDDPAW---RDEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGRRDEVFLVSK----VRPENA-- 85
Cdd:cd19080 14 ALGTMT--FGTEWGWgadREEARAMFDAYVEAGGNFIDTANNYTNGTSERLLGEFIAGNRDRIVLATKytmnRRPGDPna 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 86 ---SEMKMMLACEKSLERLGVERLDLYLLH-WEGHVPLEETVEAFRDLVDEGMIARWGVSNLD---LRAMEQLMDIEGGE 158
Cdd:cd19080 92 ggnHRKNLRRSVEASLRRLQTDYIDLLYVHaWDFTTPVEEVMRALDDLVRAGKVLYVGISDTPawvVARANTLAELRGWS 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 159 DCAANQLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRGEL--------------------LEQPLI----------RD 208
Cdd:cd19080 172 PFVALQIEYSLLERTPERELLPMARALGLGVTPWSPLGGGLLtgkyqrgeegrageakgvtvGFGKLTernwaivdvvAA 251
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 946884465 209 IANRHSASPAQVALAAVLRQDGV-IAIPKASSVEHVEANADALDIQFDLEDLERLD 263
Cdd:cd19080 252 VAEELGRSAAQVALAWVRQKPGVvIPIIGARTLEQLKDNLGALDLTLSPEQLARLD 307
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
5-264 |
3.42e-46 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 155.43 E-value: 3.42e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 5 VTFADGTTVPALGQGTWELGDDpawrDEEQQALARGIDLGMTLIDTAELYGDgrsERLVGEVI--AG-RRDEVFLVSKVR 81
Cdd:cd19133 1 VTLNNGVEMPILGFGVFQIPDP----EECERAVLEAIKAGYRLIDTAAAYGN---EEAVGRAIkkSGiPREELFITTKLW 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 82 PENASEMKMMLACEKSLERLGVERLDLYLLHWeghvPLEETVEAFR---DLVDEGMIARWGVSNLDlraMEQLMD-IEGG 157
Cdd:cd19133 74 IQDAGYEKAKKAFERSLKRLGLDYLDLYLIHQ----PFGDVYGAWRameELYKEGKIRAIGVSNFY---PDRLVDlILHN 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 158 EDC-AANQllynlasrgVEFDLF-------PWMQARDMPMMAYSPLGRG--ELLEQPLIRDIANRHSASPAQValaaVLR 227
Cdd:cd19133 147 EVKpAVNQ---------IETHPFnqqieavEFLKKYGVQIEAWGPFAEGrnNLFENPVLTEIAEKYGKSVAQV----ILR 213
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 946884465 228 ---QDGVIAIPKASSVEHVEANADALDIQFDLEDLERLDA 264
Cdd:cd19133 214 wliQRGIVVIPKSVRPERIAENFDIFDFELSDEDMEAIAA 253
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
27-266 |
7.02e-45 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 153.73 E-value: 7.02e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 27 PAWRDEEQQALAR-GIDLGMTLIDTAELYGDGRSERLVGEVIAGR-RDEVFLVSK---------VRPENASEMkMMLACE 95
Cdd:cd19083 28 PNLDEEEGKDLVReALDNGVNLLDTAFIYGLGRSEELVGEVLKEYnRNEVVIATKgahkfggdgSVLNNSPEF-LRSAVE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 96 KSLERLGVERLDLYLLHW-EGHVPLEETVEAFRDLVDEGMIARWGVSNLDLramEQLMDIEGGEDCAANQLLYNLASRGV 174
Cdd:cd19083 107 KSLKRLNTDYIDLYYIHFpDGETPKAEAVGALQELKDEGKIRAIGVSNFSL---EQLKEANKDGYVDVLQGEYNLLQREA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 175 EFDLFPWMQARDMPMMAYSPLGRGELL----------------EQPL---------------IRDIANRHSASPAQVALA 223
Cdd:cd19083 184 EEDILPYCVENNISFIPYFPLASGLLAgkytkdtkfpdndlrnDKPLfkgerfsenldkvdkLKSIADEKGVTVAHLALA 263
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 946884465 224 AVLRQDGV-IAIPKASSVEHVEANADALDIQFDLEDLERLDAAF 266
Cdd:cd19083 264 WYLTRPAIdVVIPGAKRAEQVIDNLKALDVTLTEEEIAFIDALF 307
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
5-264 |
8.10e-45 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 152.16 E-value: 8.10e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 5 VTFADGTTVPALGQGTWELGDDpawrDEEQQALARGIDLGMTLIDTAELYGDgrsERLVGEVIAGR---RDEVFLVSKVR 81
Cdd:cd19157 2 VTLNNGVKMPWLGLGVFKVEEG----SEVVNAVKTALKNGYRSIDTAAIYGN---EEGVGKGIKESgipREELFITSKVW 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 82 PENASEMKMMLACEKSLERLGVERLDLYLLHWEGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMdieggEDC- 160
Cdd:cd19157 75 NADQGYDSTLKAFEASLERLGLDYLDLYLIHWPVKGKYKETWKALEKLYKDGRVRAIGVSNFQVHHLEDLL-----ADAe 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 161 ---AANQLLYNlaSRGVEFDLFPWMQARDMPMMAYSPLGRGELLEQPLIRDIANRHSASPAQValaaVLR---QDGVIAI 234
Cdd:cd19157 150 ivpMVNQVEFH--PRLTQKELRDYCKKQGIQLEAWSPLMQGQLLDNPVLKEIAEKYNKSVAQV----ILRwdlQNGVVTI 223
|
250 260 270
....*....|....*....|....*....|
gi 946884465 235 PKASSVEHVEANADALDIQFDLEDLERLDA 264
Cdd:cd19157 224 PKSIKEHRIIENADVFDFELSQEDMDKIDA 253
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
9-264 |
8.10e-45 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 153.21 E-value: 8.10e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 9 DGTTVPALGQGTWELGDDPAWRdeeqQALARGIDLGMTLIDTAELYGDgrsERLVGEVIAG-------RRDEVFLVSKVR 81
Cdd:cd19116 7 DGNEIPAIALGTWKLKDDEGVR----QAVKHAIEAGYRHIDTAYLYGN---EAEVGEAIREkiaegvvKREDLFITTKLW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 82 PENASEMKMMLACEKSLERLGVERLDLYLLHW----------EGHVPLE-------ETVEAFRDLVDEGMIARWGVSNLD 144
Cdd:cd19116 80 NSYHEREQVEPALRESLKRLGLDYVDLYLIHWpvafkenndsESNGDGSlsdidylETWRGMEDLVKLGLTRSIGVSNFN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 145 LRAMEQLMdieggEDC----AANQLLYNLASrgVEFDLFPWMQARDMPMMAYSPLGRGEL---------LEQPLIRDIAN 211
Cdd:cd19116 160 SEQINRLL-----SNCnikpAVNQIEVHPTL--TQEKLVAYCQSNGIVVMAYSPFGRLVPrgqtnppprLDDPTLVAIAK 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 946884465 212 RHSASPAQVALAAVLrQDGVIAIPKASSVEHVEANADALDIQFDLEDLERLDA 264
Cdd:cd19116 233 KYGKTTAQIVLRYLI-DRGVVPIPKSSNKKRIKENIDIFDFQLTPEEVAALNS 284
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
9-264 |
1.09e-44 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 151.65 E-value: 1.09e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 9 DGTTVPALGQGTWELGDDPAWRdeeqqALARGIDLGMTLIDTAELYGdgrSERLVGEVIAGR---RDEVFLVSKVRPENA 85
Cdd:cd19132 3 DGTQIPAIGFGTYPLKGDEGVE-----AVVAALQAGYRLLDTAFNYE---NEGAVGEAVRRSgvpREELFVTTKLPGRHH 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 86 SEMKMMLACEKSLERLGVERLDLYLLHWeghvPLE------ETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDiEGGED 159
Cdd:cd19132 75 GYEEALRTIEESLYRLGLDYVDLYLIHW----PNPsrdlyvEAWQALIEAREEGLVRSIGVSNFLPEHLDRLID-ETGVT 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 160 CAANQllynlasrgVEFD-LFP------WMQARDMPMMAYSPLGRGE-LLEQPLIRDIANRHSASPAQVALAAVLrQDGV 231
Cdd:cd19132 150 PAVNQ---------IELHpYFPqaeqraYHREHGIVTQSWSPLGRGSgLLDEPVIKAIAEKHGKTPAQVVLRWHV-QLGV 219
|
250 260 270
....*....|....*....|....*....|...
gi 946884465 232 IAIPKASSVEHVEANADALDIQFDLEDLERLDA 264
Cdd:cd19132 220 VPIPKSANPERQRENLAIFDFELSDEDMAAIAA 252
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
10-263 |
2.07e-44 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 152.37 E-value: 2.07e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWELGddpaWRDEEQQA---LARGIDLGMTLIDTAELYGD-------GRSERLVGEVIA--GRRDEVFLV 77
Cdd:cd19081 6 GLSVSPLCLGTMVFG----WTADEETSfalLDAFVDAGGNFIDTADVYSAwvpgnagGESETIIGRWLKsrGKRDRVVIA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 78 SKVRPENA------SEMKMMLACEKSLERLGVERLDLYLLH-WEGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQ 150
Cdd:cd19081 82 TKVGFPMGpngpglSRKHIRRAVEASLRRLQTDYIDLYQAHwDDPATPLEETLGALNDLIRQGKVRYIGASNYSAWRLQE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 151 LMDI---EGGEDCAANQLLYNLASRG-VEFDLFPWMQARDMPMMAYSPLGRGEL-----LEQPL---------------- 205
Cdd:cd19081 162 ALELsrqHGLPRYVSLQPEYNLVDREsFEGELLPLCREEGIGVIPYSPLAGGFLtgkyrSEADLpgstrrgeaakrylne 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 946884465 206 --------IRDIANRHSASPAQVALAAVLRQDGVIA-IPKASSVEHVEANADALDIQFDLEDLERLD 263
Cdd:cd19081 242 rglrildaLDEVAAEHGATPAQVALAWLLARPGVTApIAGARTVEQLEDLLAAAGLRLTDEEVARLD 308
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
5-264 |
9.37e-43 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 146.92 E-value: 9.37e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 5 VTFADGTTVPALGQGTWELGDDpawrdEEQQALARGIDLGMTLIDTAELYGDgrsERLVGEVIAGR---RDEVFLVSKVR 81
Cdd:cd19134 3 VTLNDDNTMPVIGLGVGELSDD-----EAERSVSAALEAGYRLIDTAAAYGN---EAAVGRAIAASgipRGELFVTTKLA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 82 PENASEMKMMLACEKSLERLGVERLDLYLLHWEGhVPLEETVEAFRDLV---DEGMIARWGVSNLDLRAMEQLMDIEGgE 158
Cdd:cd19134 75 TPDQGFTASQAACRASLERLGLDYVDLYLIHWPA-GREGKYVDSWGGLMklrEEGLARSIGVSNFTAEHLENLIDLTF-F 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 159 DCAANQLlynlasrgvefDLFPWMQARDMP---------MMAYSPLGRGELLEQPLIRDIANRHSASPAQVALAAVLrQD 229
Cdd:cd19134 153 TPAVNQI-----------ELHPLLNQAELRkvnaqhgivTQAYSPLGVGRLLDNPAVTAIAAAHGRTPAQVLLRWSL-QL 220
|
250 260 270
....*....|....*....|....*....|....*
gi 946884465 230 GVIAIPKASSVEHVEANADALDIQFDLEDLERLDA 264
Cdd:cd19134 221 GNVVISRSSNPERIASNLDVFDFELTADHMDALDG 255
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
10-266 |
9.67e-43 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 147.76 E-value: 9.67e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQG----TWELGDdPAWRDEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGRRDEVFLVSK--VRPE 83
Cdd:cd19078 1 GLEVSAIGLGcmgmSHGYGP-PPDKEEMIELIRKAVELGITFFDTAEVYGPYTNEELVGEALKPFRDQVVIATKfgFKID 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 84 NASEMKMML---------ACEKSLERLGVERLDLYLLH-WEGHVPLEETVEAFRDLVDEGMIARWGVSnldlrameqlmd 153
Cdd:cd19078 80 GGKPGPLGLdsrpehirkAVEGSLKRLQTDYIDLYYQHrVDPNVPIEEVAGTMKELIKEGKIRHWGLS------------ 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 154 iEGGED----------CAANQLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRG------------------------- 198
Cdd:cd19078 148 -EAGVEtirrahavcpVTAVQSEYSMMWREPEKEVLPTLEELGIGFVPFSPLGKGfltgkidentkfdegddraslprft 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 946884465 199 -ELLEQ-----PLIRDIANRHSASPAQVALAAVLRQDG-VIAIPKASSVEHVEANADALDIQFDLEDLERLDAAF 266
Cdd:cd19078 227 pEALEAnqalvDLLKEFAEEKGATPAQIALAWLLAKKPwIVPIPGTTKLSRLEENIGAADIELTPEELREIEDAL 301
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
3-264 |
3.95e-42 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 146.02 E-value: 3.95e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 3 RLVTFADGTTVPALGQGTWELGddpawRDEEQQALARGIDLGMTLIDTAELYGDgrsERLVGEVIAG-------RRDEVF 75
Cdd:cd19123 2 KTLPLSNGDLIPALGLGTWKSK-----PGEVGQAVKQALEAGYRHIDCAAIYGN---EAEIGAALAEvfkegkvKREDLW 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 76 LVSK----------VRPenasemkmmlACEKSLERLGVERLDLYLLHWE-------------------GHVPLEETVEAF 126
Cdd:cd19123 74 ITSKlwnnshapedVLP----------ALEKTLADLQLDYLDLYLMHWPvalkkgvgfpesgedllslSPIPLEDTWRAM 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 127 RDLVDEGMIARWGVSNLDLRAMEQLMDiEGGEDCAANQllynlasrgVEfdLFPWMQARDM---------PMMAYSPLGR 197
Cdd:cd19123 144 EELVDKGLCRHIGVSNFSVKKLEDLLA-TARIKPAVNQ---------VE--LHPYLQQPELlafcrdngiHLTAYSPLGS 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 198 GE------------LLEQPLIRDIANRHSASPAQVALA-AVLRqdGVIAIPKASSVEHVEANADALDIQFDLEDLERLDA 264
Cdd:cd19123 212 GDrpaamkaegepvLLEDPVINKIAEKHGASPAQVLIAwAIQR--GTVVIPKSVNPERIQQNLEAAEVELDASDMATIAA 289
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
5-264 |
8.21e-42 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 144.12 E-value: 8.21e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 5 VTFADGTTVPALGQGTWELGDDpawrDEEQQALARGIDLGMTLIDTAELYgdgRSERLVGEVIAGR---RDEVFLVSKVR 81
Cdd:cd19126 1 VTLNNGTRMPWLGLGVFQTPDG----DETERAVQTALENGYRSIDTAAIY---KNEEGVGEAIRESgvpREELFVTTKLW 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 82 PENASEMKMMLACEKSLERLGVERLDLYLLHWEGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMdieggEDC- 160
Cdd:cd19126 74 NDDQRARRTEDAFQESLDRLGLDYVDLYLIHWPGKDKFIDTWKALEKLYASGKVKAIGVSNFQEHHLEELL-----AHAd 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 161 ---AANQLLYNlaSRGVEFDLFPWMQARDMPMMAYSPLGRGELLEQPLIRDIANRHSASPAQValaaVLR---QDGVIAI 234
Cdd:cd19126 149 vvpAVNQVEFH--PYLTQKELRGYCKSKGIVVEAWSPLGQGGLLSNPVLAAIGEKYGKSAAQV----VLRwdiQHGVVTI 222
|
250 260 270
....*....|....*....|....*....|
gi 946884465 235 PKASSVEHVEANADALDIQFDLEDLERLDA 264
Cdd:cd19126 223 PKSVHASRIKENADIFDFELSEDDMTAIDA 252
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
8-258 |
5.51e-41 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 143.08 E-value: 5.51e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 8 ADGTTVPALGQGTWELGDDPAWRDEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIA---GRRDEVFLVSK----- 79
Cdd:cd19092 1 PEGLEVSRLVLGCMRLADWGESAEELLSLIEAALELGITTFDHADIYGGGKCEELFGEALAlnpGLREKIEIQTKcgirl 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 80 --------VRPENASEMKMMLACEKSLERLGVERLDLYLLHWEGhvPL---EETVEAFRDLVDEGMIARWGVSNLD---L 145
Cdd:cd19092 81 gddprpgrIKHYDTSKEHILASVEGSLKRLGTDYLDLLLLHRPD--PLmdpEEVAEAFDELVKSGKVRYFGVSNFTpsqI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 146 RAMEQLMDIEggedCAANQLLYNLASRGVEFD-LFPWMQARDMPMMAYSPLGRGELL------EQPL---IRDIANRHSA 215
Cdd:cd19092 159 ELLQSYLDQP----LVTNQIELSLLHTEAIDDgTLDYCQLLDITPMAWSPLGGGRLFggfderFQRLraaLEELAEEYGV 234
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 946884465 216 SPAQVALAAVLRQ-DGVIAIPKASSVEHVEANADALDIQFDLED 258
Cdd:cd19092 235 TIEAIALAWLLRHpARIQPILGTTNPERIRSAVKALDIELTREE 278
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
10-255 |
1.43e-40 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 141.96 E-value: 1.43e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTW-----ELGDDPAwrdeeQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAG-RRDEVFLVSKVR-- 81
Cdd:cd19074 1 GLKVSELSLGTWltfggQVDDEDA-----KACVRKAYDLGINFFDTADVYAAGQAEEVLGKALKGwPRESYVISTKVFwp 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 82 --PENA----SEMKMMLACEKSLERLGVERLDLYLLH-WEGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDI 154
Cdd:cd19074 76 tgPGPNdrglSRKHIFESIHASLKRLQLDYVDIYYCHrYDPETPLEETVRAMDDLIRQGKILYWGTSEWSAEQIAEAHDL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 155 ---EGGEDCAANQLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRGEL---------------LEQPLIRD-------- 208
Cdd:cd19074 156 arqFGLIPPVVEQPQYNMLWREIEEEVIPLCEKNGIGLVVWSPLAQGLLtgkyrdgipppsrsrATDEDNRDkkrrlltd 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 946884465 209 -----------IANRHSASPAQVALAAVLRQDGVI-AIPKASSVEHVEANADALDIQFD 255
Cdd:cd19074 236 enlekvkklkpIADELGLTLAQLALAWCLRNPAVSsAIIGASRPEQLEENVKASGVKLS 294
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
5-264 |
1.60e-39 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 138.42 E-value: 1.60e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 5 VTFADGTTVPALGQGTWELGDDpawrDEEQQALARGIDLGMTLIDTAELYgdgRSERLVGEVIAG---RRDEVFLVSKVR 81
Cdd:cd19156 1 VKLANGVEMPRLGLGVWRVQDG----AEAENAVKWAIEAGYRHIDTAAIY---KNEEGVGQGIREsgvPREEVFVTTKLW 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 82 PENASEMKMMLACEKSLERLGVERLDLYLLHWEGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMdieggEDCA 161
Cdd:cd19156 74 NSDQGYESTLAAFEESLEKLGLDYVDLYLIHWPVKGKFKDTWKAFEKLYKEKKVRAIGVSNFHEHHLEELL-----KSCK 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 162 ----ANQLlyNLASRGVEFDLFPWMQARDMPMMAYSPLGRGELLEQPLIRDIANRHSASPAQValaaVLR---QDGVIAI 234
Cdd:cd19156 149 vapmVNQI--ELHPLLTQEPLRKFCKEKNIAVEAWSPLGQGKLLSNPVLKAIGKKYGKSAAQV----IIRwdiQHGIITI 222
|
250 260 270
....*....|....*....|....*....|
gi 946884465 235 PKASSVEHVEANADALDIQFDLEDLERLDA 264
Cdd:cd19156 223 PKSVHEERIQENFDVFDFELTAEEIRQIDG 252
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
16-251 |
2.59e-37 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 133.84 E-value: 2.59e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 16 LGQGTWELGDDPAWRDEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGRRDevFLV-SKVRPENA---SEMKMM 91
Cdd:cd19075 5 LGTMTFGSQGRFTTAEAAAELLDAFLERGHTEIDTARVYPDGTSEELLGELGLGERG--FKIdTKANPGVGgglSPENVR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 92 LACEKSLERLGVERLDLYLLHWEGH-VPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDIeggedCAAN------- 163
Cdd:cd19075 83 KQLETSLKRLKVDKVDVFYLHAPDRsTPLEETLAAIDELYKEGKFKEFGLSNYSAWEVAEIVEI-----CKENgwvlptv 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 164 -QLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRG--------------------------------------ELLEqp 204
Cdd:cd19075 158 yQGMYNAITRQVETELFPCLRKLGIRFYAYSPLAGGfltgkykysedkagggrfdpnnalgklyrdrywkpsyfEALE-- 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 946884465 205 LIRDIANRHSASPAQVALAAVL--------RQDGVIAipKASSVEHVEANADALD 251
Cdd:cd19075 236 KVEEAAEKEGISLAEAALRWLYhhsaldgeKGDGVIL--GASSLEQLEENLAALE 288
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
5-264 |
4.82e-37 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 132.92 E-value: 4.82e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 5 VTFADGTTVPALGQGTWELGDDpawrdEEQQALARGIDLGMTLIDTAELYgdgRSERLVGEVIA-------GRRDEVFLV 77
Cdd:cd19154 4 ITLSNGVKMPLIGLGTWQSKGA-----EGITAVRTALKAGYRLIDTAFLY---QNEEAIGEALAelleegvVKREDLFIT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 78 SKVRPENASEMKMMLACEKSLERLGVERLDLYLLH--W-----EGH-------------VPLEETVEAFRDLVDEGMIAR 137
Cdd:cd19154 76 TKLWTHEHAPEDVEEALRESLKKLQLEYVDLYLIHapAafkddEGEsgtmengmsihdaVDVEDVWRGMEKVYDEGLTKA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 138 WGVSNLDLRAMEQLMDIeGGEDCAANQL---LYNlasrgVEFDLFPWMQARDMPMMAYSPLGR---------------GE 199
Cdd:cd19154 156 IGVSNFNNDQIQRILDN-ARVKPHNNQVechLYF-----PQKELVEFCKKHNISVTSYATLGSpgranftkstgvspaPN 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 946884465 200 LLEQPLIRDIANRHSASPAQVALAAVLrQDGVIAIPKASSVEHVEANADALDIQFDLEDLERLDA 264
Cdd:cd19154 230 LLQDPIVKAIAEKHGKTPAQVLLRYLL-QRGIAVIPKSATPSRIKENFNIFDFSLSEEDMATLEE 293
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
9-269 |
8.40e-37 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 132.95 E-value: 8.40e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 9 DGTTVPALGQGTWEL--GDDPAWRDEEQQA-LARGIDLGMTLIDTAELYGDgrSERLVGEVIA---GRRDEVFLVSKV-- 80
Cdd:cd19144 9 NGPSVPALGFGAMGLsaFYGPPKPDEERFAvLDAAFELGCTFWDTADIYGD--SEELIGRWFKqnpGKREKIFLATKFgi 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 81 --------RPENASEMKMMLACEKSLERLGVERLDLYLLH-WEGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQL 151
Cdd:cd19144 87 eknvetgeYSVDGSPEYVKKACETSLKRLGVDYIDLYYQHrVDGKTPIEKTVAAMAELVQEGKIKHIGLSECSAETLRRA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 152 MDIeggEDCAANQLLYNLASRGVEFDLFPWMQA-RDM--PMMAYSPLGRG------------------------------ 198
Cdd:cd19144 167 HAV---HPIAAVQIEYSPFSLDIERPEIGVLDTcRELgvAIVAYSPLGRGfltgairspddfeegdfrrmaprfqaenfp 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 946884465 199 ---ELLEQplIRDIANRHSASPAQVALAAVLRQ-DGVIAIPKASSVEHVEANADALDIQFDLEDL---ERLDAAFPPP 269
Cdd:cd19144 244 knlELVDK--IKAIAKKKNVTAGQLTLAWLLAQgDDIIPIPGTTKLKRLEENLGALKVKLTEEEEkeiREIAEEAEVV 319
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
10-200 |
1.60e-36 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 131.66 E-value: 1.60e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWELGDDPAWRDEEQQALA---RGIDLGMTLIDTAELYGDGRSERLVGEVIA--GRRDEVFLVSKV---- 80
Cdd:cd19148 1 DLPVSRIALGTWAIGGWMWGGTDEKEAIEtihKALDLGINLIDTAPVYGFGLSEEIVGKALKeyGKRDRVVIATKVglew 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 81 -----RPENASEMKMMLACEKSLERLGVERLDLYLLHW-EGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLmdi 154
Cdd:cd19148 81 deggeVVRNSSPARIRKEVEDSLRRLQTDYIDLYQVHWpDPLVPIEETAEALKELLDEGKIRAIGVSNFSPEQMETF--- 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 946884465 155 EGGEDCAANQLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRGEL 200
Cdd:cd19148 158 RKVAPLHTVQPPYNLFEREIEKDVLPYARKHNIVTLAYGALCRGLL 203
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
5-264 |
4.69e-36 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 129.26 E-value: 4.69e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 5 VTFADGTTVPALGQGTWELgdDPAwrdEEQQALARGIDLGMTLIDTAELYGDgrsERLVGEVIAGR---RDEVFLVSKVR 81
Cdd:cd19130 2 IVLNDGNSIPQLGYGVFKV--PPA---DTQRAVATALEVGYRHIDTAAIYGN---EEGVGAAIAASgipRDELFVTTKLW 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 82 PENASEMKMMLACEKSLERLGVERLDLYLLHWeghvPLE------ETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDiE 155
Cdd:cd19130 74 NDRHDGDEPAAAFAESLAKLGLDQVDLYLVHW----PTPaagnyvHTWEAMIELRAAGRTRSIGVSNFLPPHLERIVA-A 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 156 GGEDCAANQLlyNLASRGVEFDLFPWMQARDMPMMAYSPLGRGELLEQPLIRDIANRHSASPAQvalaAVLR---QDGVI 232
Cdd:cd19130 149 TGVVPAVNQI--ELHPAYQQRTIRDWAQAHDVKIEAWSPLGQGKLLGDPPVGAIAAAHGKTPAQ----IVLRwhlQKGHV 222
|
250 260 270
....*....|....*....|....*....|..
gi 946884465 233 AIPKASSVEHVEANADALDIQFDLEDLERLDA 264
Cdd:cd19130 223 VFPKSVRRERMEDNLDVFDFDLTDTEIAAIDA 254
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
5-264 |
2.79e-35 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 127.52 E-value: 2.79e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 5 VTFADGTTVPALGQGTWELgddPAwrDEEQQALARGIDLGMTLIDTAELYGDgrsERLVGEVI---AGRRDEVFLVSKVR 81
Cdd:cd19127 1 ITLNNGVEMPALGLGVFQT---PP--EETADAVATALADGYRLIDTAAAYGN---EREVGEGIrrsGVDRSDIFVTTKLW 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 82 PENASEMKMMLACEKSLERLGVERLDLYLLHWEGHVPLEETVEAFRDL---VDEGMIARWGVSNLDLRAMEQLMDiEGGE 158
Cdd:cd19127 73 ISDYGYDKALRGFDASLRRLGLDYVDLYLLHWPVPNDFDRTIQAYKALeklLAEGRVRAIGVSNFTPEHLERLID-ATTV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 159 DCAANQllynlasrgVEfdLFPWMQARDM---------PMMAYSPLG------------RGELLEQPLIRDIANRHSASP 217
Cdd:cd19127 152 VPAVNQ---------VE--LHPYFSQKDLrafhrrlgiVTQAWSPIGgvmrygasgptgPGDVLQDPTITGLAEKYGKTP 220
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 946884465 218 AQValaaVLR---QDGVIAIPKASSVEHVEANADALDIQFDLEDLERLDA 264
Cdd:cd19127 221 AQI----VLRwhlQNGVSAIPKSVHPERIAENIDIFDFALSAEDMAAIDA 266
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
12-248 |
4.44e-35 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 128.20 E-value: 4.44e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 12 TVPALGQGTWELGDDPAWRDEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAG-------RRDEVFLVSKV---- 80
Cdd:cd19099 2 TLSSLGLGTYRGDSDDETDEEYREALKAALDSGINVIDTAINYRGGRSERLIGKALREliekggiKRDEVVIVTKAgyip 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 81 --RPENASEMKMML---------------------------ACEKSLERLGVERLDLYLLHW-EGHVP----------LE 120
Cdd:cd19099 82 gdGDEPLRPLKYLEeklgrglidvadsaglrhcispayledQIERSLKRLGLDTIDLYLLHNpEEQLLelgeeefydrLE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 121 ETVEAFRDLVDEGMIARWGVS-------------NLDLRAMEQLMDIEGGED--CAANQLLYNLASRG-------VEFDL 178
Cdd:cd19099 162 EAFEALEEAVAEGKIRYYGIStwdgfrappalpgHLSLEKLVAAAEEVGGDNhhFKVIQLPLNLLEPEaltekntVKGEA 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 946884465 179 FPWMQA---RDMPMMAYSPLGRGELL-EQPLIRDIANRHSASPAQVALAAVLRQDGVI-AIPKASSVEHVEANAD 248
Cdd:cd19099 242 LSLLEAakeLGLGVIASRPLNQGQLLgELRLADLLALPGGATLAQRALQFARSTPGVDsALVGMRRPEHVDENLA 316
|
|
| AKR_AKR1E1-2 |
cd19110 |
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ... |
13-267 |
7.54e-34 |
|
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.
Pssm-ID: 381336 [Multi-domain] Cd Length: 301 Bit Score: 124.69 E-value: 7.54e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 13 VPALGQGTWElgddpAWRDEEQQALARGIDLGMTLIDTAELYgdgRSERLVGEVI-------AGRRDEVFLVSKVRPENA 85
Cdd:cd19110 4 IPAVGLGTWK-----ASPGEVTEAVKVAIDAGYRHFDCAYLY---HNESEVGAGIrekikegVVRREDLFIVSKLWCTCH 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 86 SEMKMMLACEKSLERLGVERLDLYLLHW-------EGHVPLEE-------------TVEAFRDLVDEGMIARWGVSNLDL 145
Cdd:cd19110 76 KKSLVKTACTRSLKALKLNYLDLYLIHWpmgfkpgEPDLPLDRsgmvipsdtdfldTWEAMEDLVIEGLVKNIGVSNFNH 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 146 RAMEQLMDIEGgedcaanqLLYNLASRGVEF-------DLFPWMQARDMPMMAYSPLGRG----ELLEQPLIRDIANRHS 214
Cdd:cd19110 156 EQLERLLNKPG--------LRVKPVTNQIEChpyltqkKLISFCQSRNVSVTAYRPLGGScegvDLIDDPVIQRIAKKHG 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 946884465 215 ASPAQVaLAAVLRQDGVIAIPKASSVEHVEANADALDIQF---DLEDLERLD-----AAFP 267
Cdd:cd19110 228 KSPAQI-LIRFQIQRNVIVIPKSVTPSRIKENIQVFDFELtehDMDNLLSLDrnlrlATFP 287
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
10-265 |
9.50e-34 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 123.50 E-value: 9.50e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGT---WELGDDPAWRDEEQQALARGIDLGMTLIDTAELYGDgrsERLVGEVIA---GRRDEVFLVSKVRPE 83
Cdd:cd19120 1 GSKIPAIAFGTgtaWYKSGDDDIQRDLVDSVKLALKAGFRHIDTAEMYGN---EKEVGEALKesgVPREDLFITTKVSPG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 84 NASEMKmmlACEKSLERLGVERLDLYLLHW-----EGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDiegge 158
Cdd:cd19120 78 IKDPRE---ALRKSLAKLGVDYVDLYLIHSpffakEGGPTLAEAWAELEALKDAGLVRSIGVSNFRIEDLEELLD----- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 159 DC----AANQLLYN--LASRGVefDLFPWMQARDMPMMAYSPL-----GRGELLEQPLiRDIANRHSASPAQVALAAVLr 227
Cdd:cd19120 150 TAkikpAVNQIEFHpyLYPQQP--ALLEYCREHGIVVSAYSPLspltrDAGGPLDPVL-EKIAEKYGVTPAQVLLRWAL- 225
|
250 260 270
....*....|....*....|....*....|....*...
gi 946884465 228 QDGVIAIPKASSVEHVEANADALDIQFDLEDLERLDAA 265
Cdd:cd19120 226 QKGIVVVTTSSKEERMKEYLEAFDFELTEEEVEEIDKA 263
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
10-250 |
1.80e-33 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 122.31 E-value: 1.80e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTwelgddPAWRDEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAG-RRDEVFLVSKVRPENASE- 87
Cdd:cd19105 10 GLKVSRLGFGG------GGLPRESPELLRRALDLGINYFDTAEGYGNGNSEEIIGEALKGlRRDKVFLATKASPRLDKKd 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 88 ----MKMMlacEKSLERLGVERLDLYLLHW----EGHVPLEETVEAFRDLVDEGMIaRW-GVSNLDlrAMEQLMD--IEG 156
Cdd:cd19105 84 kaelLKSV---EESLKRLQTDYIDIYQLHGvdtpEERLLNEELLEALEKLKKEGKV-RFiGFSTHD--NMAEVLQaaIES 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 157 GE-DCAanQLLYNLASRGVEFD-LFPWMQARDMPMMAYSPLGRGelLEQPLIRDIANRHSASPAQVALAAVLRQDGV-IA 233
Cdd:cd19105 158 GWfDVI--MVAYNFLNQPAELEeALAAAAEKGIGVVAMKTLAGG--YLQPALLSVLKAKGFSLPQAALKWVLSNPRVdTV 233
|
250
....*....|....*..
gi 946884465 234 IPKASSVEHVEANADAL 250
Cdd:cd19105 234 VPGMRNFAELEENLAAA 250
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
41-251 |
3.48e-33 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 122.66 E-value: 3.48e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 41 IDLGMTLIDTAELYGD----GRSERLVGEVIAGR--RDEVFLVSK-----VRPENASEM--KMMLA-CEKSLERLGVERL 106
Cdd:cd19082 27 VELGGNFIDTARVYGDwverGASERVIGEWLKSRgnRDKVVIATKgghpdLEDMSRSRLspEDIRAdLEESLERLGTDYI 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 107 DLYLLHW-EGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDI---EGGEDCAANQLLYNLA---------SRG 173
Cdd:cd19082 107 DLYFLHRdDPSVPVGEIVDTLNELVRAGKIRAFGASNWSTERIAEANAYakaHGLPGFAASSPQWSLArpneppwpgPTL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 174 VEFD--LFPWMQARDMPMMAYSPLGRG--------ELLEQPLIRD----------------IANRHSASPAQVALAAVLR 227
Cdd:cd19082 187 VAMDeeMRAWHEENQLPVFAYSSQARGffskraagGAEDDSELRRvyyseenferlerakeLAEEKGVSPTQIALAYVLN 266
|
250 260
....*....|....*....|....*
gi 946884465 228 QD-GVIAIPKASSVEHVEANADALD 251
Cdd:cd19082 267 QPfPTVPIIGPRTPEQLRDSLAAAD 291
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
10-262 |
2.92e-32 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 120.62 E-value: 2.92e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWELGDDPAWRDEEQQALA---RGIDLGMTLIDTAELYGDGRSERLVGEVI-AGRRDEVFLVSKVRPENA 85
Cdd:cd19145 9 GLEVSAQGLGCMGLSGDYGAPKPEEEGIAlihHAFNSGVTFLDTSDIYGPNTNEVLLGKALkDGPREKVQLATKFGIHEI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 86 SEMKMML---------ACEKSLERLGVERLDLYLLHWEGH-VPLEETVEAFRDLVDEGMIARWGVSNL---DLRAMEQLM 152
Cdd:cd19145 89 GGSGVEVrgdpayvraACEASLKRLDVDYIDLYYQHRIDTtVPIEITMGELKKLVEEGKIKYIGLSEAsadTIRRAHAVH 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 153 DIeggedcAANQLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRG---------ELLEQPLIR---------------- 207
Cdd:cd19145 169 PI------TAVQLEWSLWTRDIEEEIIPTCRELGIGIVPYSPLGRGffagkakleELLENSDVRkshprfqgenleknkv 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 946884465 208 ------DIANRHSASPAQVALAAVLRQ-DGVIAIPKASSVEHVEANADALDIQFDLEDLERL 262
Cdd:cd19145 243 lyerveALAKKKGCTPAQLALAWVLHQgEDVVPIPGTTKIKNLNQNIGALSVKLTKEDLKEI 304
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
7-264 |
4.34e-32 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 120.18 E-value: 4.34e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 7 FADGTTVPALGQGTWElgDDPAwrdEEQQALARGIDLGMTLIDTAELYGDgrsERLVGEVI--------AGRRDEVFLVS 78
Cdd:cd19106 1 LHTGQKMPLIGLGTWK--SKPG---QVKAAVKYALDAGYRHIDCAAVYGN---EQEVGEALkekvgpgkAVPREDLFVTS 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 79 KV-----RPENASEmkmmlACEKSLERLGVERLDLYLLHW---------------EG-----HVPLEETVEAFRDLVDEG 133
Cdd:cd19106 73 KLwntkhHPEDVEP-----ALRKTLKDLQLDYLDLYLIHWpyafergdnpfpknpDGtirydSTHYKETWKAMEKLVDKG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 134 MIARWGVSNLDLRAMEQLMDIeGGEDCAANQLL---YNLASRGVEFdlfpwMQARDMPMMAYSPLGR--------GE--L 200
Cdd:cd19106 148 LVKAIGLSNFNSRQIDDILSV-ARIKPAVLQVEchpYLAQNELIAH-----CKARGLVVTAYSPLGSpdrpwakpDEpvL 221
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 946884465 201 LEQPLIRDIANRHSASPAQValaaVLR---QDGVIAIPKASSVEHVEANADALDIQFDLEDLERLDA 264
Cdd:cd19106 222 LEEPKVKALAKKYNKSPAQI----LLRwqvQRGVVVIPKSVTPSRIKQNIQVFDFTLSPEEMKQLDA 284
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
14-249 |
5.55e-32 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 118.49 E-value: 5.55e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 14 PALGQGTWELGDDPAWRDEEQ--QALARGIDLGMTLIDTAELYGdgRSERLVGEVIAG-RRDEVFLVSKVRPENASEMKM 90
Cdd:cd19095 1 SVLGLGTSGIGRVWGVPSEAEaaRLLNTALDLGINLIDTAPAYG--RSEERLGRALAGlRRDDLFIATKVGTHGEGGRDR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 91 ML--------ACEKSLERLGVERLDLYLLHW-EGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQlmdIEGGE-DC 160
Cdd:cd19095 79 KDfspaairaSIERSLRRLGTDYIDLLQLHGpSDDELTGEVLETLEDLKAAGKVRYIGVSGDGEELEAA---IASGVfDV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 161 AanQLLYNLASRGVEfDLFPWMQARDMPMMAYSPLGRGELLEQ-----------PLIRDIANRHSASPAQVALAAVLRQD 229
Cdd:cd19095 156 V--QLPYNVLDREEE-ELLPLAAEAGLGVIVNRPLANGRLRRRvrrrplyadyaRRPEFAAEIGGATWAQAALRFVLSHP 232
|
250 260
....*....|....*....|.
gi 946884465 230 GV-IAIPKASSVEHVEANADA 249
Cdd:cd19095 233 GVsSAIVGTTNPEHLEENLAA 253
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
4-259 |
5.98e-32 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 119.02 E-value: 5.98e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 4 LVTFADGTTVPALGQGTWELGDDpawrdEEQQALARGIDLGMTLIDTAELYGDgrsERLVGEVIAGR---RDEVFLVSKV 80
Cdd:PRK11565 6 VIKLQDGNVMPQLGLGVWQASNE-----EVITAIHKALEVGYRSIDTAAIYKN---EEGVGKALKEAsvaREELFITTKL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 81 RpeNASEMKMMLACEKSLERLGVERLDLYLLHWEghVPLEET-VEAFRDLVD---EGMIARWGVSNLDLRAMEQLMDiEG 156
Cdd:PRK11565 78 W--NDDHKRPREALEESLKKLQLDYVDLYLMHWP--VPAIDHyVEAWKGMIElqkEGLIKSIGVCNFQIHHLQRLID-ET 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 157 GEDCAANQLlynlasrgvefDLFPWMQARDM---------PMMAYSPLGRG--ELLEQPLIRDIANRHSASPAQValaaV 225
Cdd:PRK11565 153 GVTPVINQI-----------ELHPLMQQRQLhawnathkiQTESWSPLAQGgkGVFDQKVIRDLADKYGKTPAQI----V 217
|
250 260 270
....*....|....*....|....*....|....*..
gi 946884465 226 LR---QDGVIAIPKASSVEHVEANADALDIQFDLEDL 259
Cdd:PRK11565 218 IRwhlDSGLVVIPKSVTPSRIAENFDVFDFRLDKDEL 254
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
37-264 |
8.74e-32 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 119.59 E-value: 8.74e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 37 LARGIDLGMTLIDTAELY-------GDGRSERLVGEVIA--GRRDEVFLVSKV------------RPENASEMKMMLACE 95
Cdd:cd19094 24 LDYAFDEGVNFIDTAEMYpvppspeTQGRTEEIIGSWLKkkGNRDKVVLATKVagpgegitwprgGGTRLDRENIREAVE 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 96 KSLERLGVERLDLYLLHW-------------------EGHVPLEETVEAFRDLVDEGMIARWGVSN---LDLRAMEQLMD 153
Cdd:cd19094 104 GSLKRLGTDYIDLYQLHWpdrytplfgggyytepseeEDSVSFEEQLEALGELVKAGKIRHIGLSNetpWGVMKFLELAE 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 154 IEGGEDCAANQLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRGEL-------------------------LEQPLIR- 207
Cdd:cd19094 184 QLGLPRIVSIQNPYSLLNRNFEEGLAEACHRENVGLLAYSPLAGGVLtgkyldgaarpeggrlnlfpgymarYRSPQALe 263
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 946884465 208 ------DIANRHSASPAQVALAAVLRQDGVI-AIPKASSVEHVEANADALDIQFDLEDLERLDA 264
Cdd:cd19094 264 avaeyvKLARKHGLSPAQLALAWVRSRPFVTsTIIGATTLEQLKENIDAFDVPLSDELLAEIDA 327
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
31-251 |
1.56e-31 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 118.20 E-value: 1.56e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 31 DEEQ--QALARGIDLGMTLIDTAELYG-------DGRSERLVGEVIA--GRRDEVFLVSKVR------------PENASE 87
Cdd:cd19752 15 DEETsfAILDRYVAAGGNFLDTANNYAfwteggvGGESERLIGRWLKdrGNRDDVVIATKVGagprdpdggpesPEGLSA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 88 MKMMLACEKSLERLGVERLDLYLLHWEG-HVPLEETVEAFRDLVDEGMIARWGVSNLD---LRAMEQLMDIEGGEDCAAN 163
Cdd:cd19752 95 ETIEQEIDKSLRRLGTDYIDLYYAHVDDrDTPLEETLEAFNELVKAGKVRAIGASNFAawrLERARQIARQQGWAEFSAI 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 164 QLLYNL----------ASRGVEFDLFPWMQAR-DMPMMAYSPLGRG-------ELLEQ----------PLIRDIANRHSA 215
Cdd:cd19752 175 QQRHSYlrprpgadfgVQRIVTDELLDYASSRpDLTLLAYSPLLSGaytrpdrPLPEQydgpdsdarlAVLEEVAGELGA 254
|
250 260 270
....*....|....*....|....*....|....*..
gi 946884465 216 SPAQVALAAVLRQD-GVIAIPKASSVEHVEANADALD 251
Cdd:cd19752 255 TPNQVVLAWLLHRTpAIIPLLGASTVEQLEENLAALD 291
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
9-263 |
5.30e-31 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 116.60 E-value: 5.30e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 9 DGTTVPALGQGTwelGDDPAWRDEEQQALARGIDLGMTLIDTAELYGdgrSERLVGEVIA--------GRRDEVFLVSKV 80
Cdd:cd19124 1 SGQTMPVIGMGT---ASDPPSPEDIKAAVLEAIEVGYRHFDTAAAYG---TEEALGEALAealrlglvKSRDELFVTSKL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 81 RPENASEMKMMLACEKSLERLGVERLDLYLLHW---------------EGHVPL--EETVEAFRDLVDEGMIARWGVSNL 143
Cdd:cd19124 75 WCSDAHPDLVLPALKKSLRNLQLEYVDLYLIHWpvslkpgkfsfpieeEDFLPFdiKGVWEAMEECQRLGLTKAIGVSNF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 144 DLRAMEQLMDIEGGEDcAANQLLYNLAsrgvefdlfpWMQ--------ARDMPMMAYSPLGRG-------ELLEQPLIRD 208
Cdd:cd19124 155 SCKKLQELLSFATIPP-AVNQVEMNPA----------WQQkklrefckANGIHVTAYSPLGAPgtkwgsnAVMESDVLKE 223
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 946884465 209 IANRHSASPAQVALAAVLRQdGVIAIPKASSVEHVEANADALDIQFDLEDLERLD 263
Cdd:cd19124 224 IAAAKGKTVAQVSLRWVYEQ-GVSLVVKSFNKERMKQNLDIFDWELTEEDLEKIS 277
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
3-263 |
6.96e-31 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 116.29 E-value: 6.96e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 3 RLVTFADGTTVPALGQGTWELGDDPAwrdeeQQALARGIDLGMTLIDTAELYGDgrsERLVGEVI-------AGRRDEVF 75
Cdd:cd19125 1 RFFKLNTGAKIPAVGLGTWQADPGVV-----GNAVKTAIKEGYRHIDCAAIYGN---EKEIGKALkklfedgVVKREDLF 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 76 LVSKVRPENASEMKMMLACEKSLERLGVERLDLYLLHWEGHV---------------PLEETVEAFRDLVDEGMIARWGV 140
Cdd:cd19125 73 ITSKLWCTDHAPEDVPPALEKTLKDLQLDYLDLYLIHWPVRLkkgahmpepeevlppDIPSTWKAMEKLVDSGKVRAIGV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 141 SNLDLRAMEQLMDIEGGEDcAANQllynlasrgVEF-------DLFPWMQARDMPMMAYSPLGRGE-------LLEQPLI 206
Cdd:cd19125 153 SNFSVKKLEDLLAVARVPP-AVNQ---------VEChpgwqqdKLHEFCKSKGIHLSAYSPLGSPGttwvkknVLKDPIV 222
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 946884465 207 RDIANRHSASPAQVALAAVLrQDGVIAIPKASSVEHVEANADALDIQFDLEDLERLD 263
Cdd:cd19125 223 TKVAEKLGKTPAQVALRWGL-QRGTSVLPKSTNEERIKENIDVFDWSIPEEDFAKFS 278
|
|
| AKR_AKR3D1 |
cd19121 |
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ... |
10-263 |
9.89e-31 |
|
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.
Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 115.71 E-value: 9.89e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWElgddpAWRDEEQQALARGIDLGMTLIDTAELYGDgrsERLVG----EVIAG--RRDEVFLVSKVRpe 83
Cdd:cd19121 9 GASIPAVGLGTWQ-----AKAGEVKAAVAHALKIGYRHIDGALCYQN---EDEVGegikEAIAGgvKREDLFVTTKLW-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 84 NASEMKMMLACEKSLERLGVERLDLYLLHW------EGHVPLEETVE-AFRDLV-DEGMIARW---------------GV 140
Cdd:cd19121 79 STYHRRVELCLDRSLKSLGLDYVDLYLVHWpvllnpNGNHDLFPTLPdGSRDLDwDWNHVDTWkqmekvlktgktkaiGV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 141 SNLDLRAMEQLMDiEGGEDCAANQLlyNLASRGVEFDLFPWMQARDMPMMAYSPLGR--GELLEQPLIRDIANRHSASPA 218
Cdd:cd19121 159 SNYSIPYLEELLK-HATVVPAVNQV--ENHPYLPQQELVDFCKEKGILIEAYSPLGStgSPLISDEPVVEIAKKHNVGPG 235
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 946884465 219 QVALA-AVLRqdGVIAIPKASSVEHVEANADALDiqFDLEDLERLD 263
Cdd:cd19121 236 TVLISyQVAR--GAVVLPKSVTPDRIKSNLEIID--LDDEDMNKLN 277
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
10-248 |
2.95e-30 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 113.35 E-value: 2.95e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWELGDDPawRDEEQQALARGIDLGMTLIDTAELYGDgrSERLVGEVIAGRRDEVFLVSKVRPENASEMK 89
Cdd:cd19100 8 GLKVSRLGFGGGPLGRLS--QEEAAAIIRRALDLGINYFDTAPSYGD--SEEKIGKALKGRRDKVFLATKTGARDYEGAK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 90 MMLacEKSLERLGVERLDLYLLHwegHVPLEETV----------EAFRDLVDEGMIARWGVSNLDLRAMEQLMDIeggED 159
Cdd:cd19100 84 RDL--ERSLKRLGTDYIDLYQLH---AVDTEEDLdqvfgpggalEALLEAKEEGKIRFIGISGHSPEVLLRALET---GE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 160 CAANQLLYNLASRGV---EFDLFPWMQARDMPMMAYSPLGRGELLeqplirdiaNRHSASPAQvALAAVLRQDGV-IAIP 235
Cdd:cd19100 156 FDVVLFPINPAGDHIdsfREELLPLAREKGVGVIAMKVLAGGRLL---------SGDPLDPEQ-ALRYALSLPPVdVVIV 225
|
250
....*....|...
gi 946884465 236 KASSVEHVEANAD 248
Cdd:cd19100 226 GMDSPEELDENLA 238
|
|
| AKR_AKR1B1-19 |
cd19107 |
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ... |
10-262 |
3.73e-30 |
|
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.
Pssm-ID: 381333 [Multi-domain] Cd Length: 307 Bit Score: 114.82 E-value: 3.73e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWElgdDPAWRDEEqqALARGIDLGMTLIDTAELYgdgRSERLVGEVI-------AGRRDEVFLVSKVRP 82
Cdd:cd19107 1 GAKMPILGLGTWK---SPPGQVTE--AVKVAIDAGYRHIDCAYVY---QNENEVGEAIqekikeqVVKREDLFIVSKLWC 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 83 ENASEMKMMLACEKSLERLGVERLDLYLLHW-------EGHVPLEE-------------TVEAFRDLVDEGMIARWGVSN 142
Cdd:cd19107 73 TFHEKGLVKGACQKTLSDLKLDYLDLYLIHWptgfkpgKELFPLDEsgnvipsdttfldTWEAMEELVDEGLVKAIGVSN 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 143 LDLRAMEQLMDIEGgedcaanqLLYNLASRGVEF-------DLFPWMQARDMPMMAYSPLGRGE----------LLEQPL 205
Cdd:cd19107 153 FNHLQIERILNKPG--------LKYKPAVNQIEChpyltqeKLIQYCQSKGIVVTAYSPLGSPDrpwakpedpsLLEDPK 224
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 946884465 206 IRDIANRHSASPAQVaLAAVLRQDGVIAIPKASSVEHVEANADALDIQFDLEDLERL 262
Cdd:cd19107 225 IKEIAAKHNKTTAQV-LIRFPIQRNLVVIPKSVTPERIAENFKVFDFELSSEDMATI 280
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
10-265 |
5.53e-30 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 115.69 E-value: 5.53e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWelgddPAWRDEEQQA---LARGIDLGMTLIDTAelYGDGRSERLVGEVIAGRRDEVFLVSK--VRPEN 84
Cdd:COG1453 10 GLEVSVLGFGGM-----RLPRKDEEEAealIRRAIDNGINYIDTA--RGYGDSEEFLGKALKGPRDKVILATKlpPWVRD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 85 ASEMKMMLacEKSLERLGVERLDLYLLH-------WEGHVPLEETVEAFRDLVDEGMIARWGVS---NLDLraMEQLmdI 154
Cdd:COG1453 83 PEDMRKDL--EESLKRLQTDYIDLYLIHglnteedLEKVLKPGGALEALEKAKAEGKIRHIGFSthgSLEV--IKEA--I 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 155 EGGE-DCAanQLLYNLAsrgveFDLFPWMQA-------RDMPMMAYSPLGRGELLEQPLIRDIANRHSASPAQVALAAVL 226
Cdd:COG1453 157 DTGDfDFV--QLQYNYL-----DQDNQAGEEaleaaaeKGIGVIIMKPLKGGRLANPPEKLVELLCPPLSPAEWALRFLL 229
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 946884465 227 RQDGV-IAIPKASSVEHVEANADALD--IQFDLEDLERLDAA 265
Cdd:COG1453 230 SHPEVtTVLSGMSTPEQLDENLKTADnlEPLTEEELAILERL 271
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
14-251 |
3.13e-29 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 111.11 E-value: 3.13e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 14 PALGQGTW---ELGDDPAWRDEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGR-RDEVFLVSKV---RPENAS 86
Cdd:cd19096 1 SVLGFGTMrlpESDDDSIDEEKAIEMIRYAIDAGINYFDTAYGYGGGKSEEILGEALKEGpREKFYLATKLppwSVKSAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 87 EMKMMLacEKSLERLGVERLDLYLLHWEGHVPLEET------VEAFRDLVDEGMIARWGVSNLDlrAMEQLMDIEGGEDC 160
Cdd:cd19096 81 DFRRIL--EESLKRLGVDYIDFYLLHGLNSPEWLEKarkgglLEFLEKAKKEGLIRHIGFSFHD--SPELLKEILDSYDF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 161 AANQLLYNL-------ASRGVEfdlfpWMQARDMPMMAYSPLGRGELLEQP-LIRDIANRHSASPAQVALAAVLRQDGV- 231
Cdd:cd19096 157 DFVQLQYNYldqenqaGRPGIE-----YAAKKGMGVIIMEPLKGGGLANNPpEALAILCGAPLSPAEWALRFLLSHPEVt 231
|
250 260
....*....|....*....|
gi 946884465 232 IAIPKASSVEHVEANADALD 251
Cdd:cd19096 232 TVLSGMSTPEQLDENIAAAD 251
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
14-249 |
1.54e-28 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 109.95 E-value: 1.54e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 14 PALGQGTWELGDDPAWRDEEQ--QALARGIDLGMTLIDTAELYGDgrSERLVGEVIAG-RRDEVFLVSKVRPENA----- 85
Cdd:cd19090 1 SALGLGTAGLGGVFGGVDDDEavATIRAALDLGINYIDTAPAYGD--SEERLGLALAElPREPLVLSTKVGRLPEdtady 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 86 SEMKMMLACEKSLERLGVERLDLYLLH------WEGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLmdIEGGE- 158
Cdd:cd19090 79 SADRVRRSVEESLERLGRDRIDLLMIHdpervpWVDILAPGGALEALLELKEEGLIKHIGLGGGPPDLLRRA--IETGDf 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 159 DCAANQLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRGELLEQPL--------------------IRDIANRHSASPA 218
Cdd:cd19090 157 DVVLTANRYTLLDQSAADELLPAAARHGVGVINASPLGMGLLAGRPPervrytyrwlspelldrakrLYELCDEHGVPLP 236
|
250 260 270
....*....|....*....|....*....|..
gi 946884465 219 QVALAAVLRQDGVIA-IPKASSVEHVEANADA 249
Cdd:cd19090 237 ALALRFLLRDPRISTvLVGASSPEELEQNVAA 268
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
10-263 |
1.78e-28 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 109.90 E-value: 1.78e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWELGDDpawrdEEQQALARGIDLGMTLIDTAELYGDgrsERLVGEVIAGR---RDEVFLVSKV------ 80
Cdd:cd19117 11 GAEIPAVGLGTWQSKPN-----EVAKAVEAALKAGYRHIDTAAIYGN---EEEVGQGIKDSgvpREEIFITTKLwctwhr 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 81 RPENAsemkmmlaCEKSLERLGVERLDLYLLHWEghVPL------------------------EETVEAFRDLVDEGMIA 136
Cdd:cd19117 83 RVEEA--------LDQSLKKLGLDYVDLYLMHWP--VPLdpdgndflfkkddgtkdhepdwdfIKTWELMQKLPATGKVK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 137 RWGVSNLDLRAMEQLMDIEGGEDC-AANQ--LLYNLASRgvefDLFPWMQARDMPMMAYSPLGR--GELLEQPLIRDIAN 211
Cdd:cd19117 153 AIGVSNFSIKNLEKLLASPSAKIVpAVNQieLHPLLPQP----KLVDFCKSKGIHATAYSPLGStnAPLLKEPVIIKIAK 228
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 946884465 212 RHSASPAQVALAAVLrQDGVIAIPKASSVEHVEANADAldiqFDL--EDLERLD 263
Cdd:cd19117 229 KHGKTPAQVIISWGL-QRGYSVLPKSVTPSRIESNFKL----FTLsdEEFKEID 277
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
10-263 |
2.30e-28 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 109.90 E-value: 2.30e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWElgddpAWRDEEQQALARGIDLGMTLIDTAELYGDgrsERLVGEVIAG-------RRDEVFLVSKVRP 82
Cdd:cd19111 1 GFPMPVIGLGTYQ-----SPPEEVRAAVDYALFVGYRHIDTALSYQN---EKAIGEALKWwlkngklKREEVFITTKLPP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 83 ENASEMKMMLACEKSLERLGVERLDLYLLHWEGHV--------------PLEETVEAFRDLVDEGMIARWGVSNLDLRAM 148
Cdd:cd19111 73 VYLEFKDTEKSLEKSLENLKLPYVDLYLIHHPCGFvnkkdkgerelassDVTSVWRAMEALVSEGKVKSIGLSNFNPRQI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 149 EQLMDIegGEDCAAN-QLLYNLASRgvEFDLFPWMQARDMPMMAYSPLG---RGE---------LLEQPLIRDIANRHSA 215
Cdd:cd19111 153 NKILAY--AKVKPSNlQLECHAYLQ--QRELRKFCNKKNIVVTAYAPLGspgRANqslwpdqpdLLEDPTVLAIAKELDK 228
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 946884465 216 SPAQVALAAVLrQDGVIAIPKASSVEHVEANADALDIQFDLEDLERLD 263
Cdd:cd19111 229 TPAQVLLRFVL-QRGTGVLPKSTNKERIEENFEVFDFELTEEHFKKLK 275
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
30-266 |
2.42e-28 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 110.43 E-value: 2.42e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 30 RDEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGRRDEVFLVSKVR--PENASEMKMML--ACEKSLERLGVER 105
Cdd:cd19104 31 REEQIAAVRRALDLGINFFDTAPSYGDGKSEENLGRALKGLPAGPYITTKVRldPDDLGDIGGQIerSVEKSLKRLKRDS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 106 LDLYLLH--------WEGHVPL--------EETVEAFRDLVDEGMIARWGVSNLD-LRAMEQLmdIEGGEDCAAnQLLYN 168
Cdd:cd19104 111 VDLLQLHnrigderdKPVGGTLsttdvlglGGVADAFERLRSEGKIRFIGITGLGnPPAIREL--LDSGKFDAV-QVYYN 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 169 L-----------ASRGVEFD-LFPWMQARDMPMMAYSPLGRGEL-------LEQPL---------------IRDIANRHS 214
Cdd:cd19104 188 LlnpsaaearprGWSAQDYGgIIDAAAEHGVGVMGIRVLAAGALttsldrgREAPPtsdsdvaidfrraaaFRALAREWG 267
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 946884465 215 ASPAQVALAAVLRQDGV-IAIPKASSVEHVE-----ANADALDIqfdlEDLERLDAAF 266
Cdd:cd19104 268 ETLAQLAHRFALSNPGVsTVLVGVKNREELEeavaaEAAGPLPA----ENLARLEALW 321
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
12-265 |
3.30e-28 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 109.61 E-value: 3.30e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 12 TVPALGQGTWEL-GDDPAWRDEEQ--QALARGIDLGMTLIDTAELYGdgRSERLVGEVIAGRRDEVFLVSKVR------P 82
Cdd:cd19101 1 TISRVINGMWQLsGGHGGIRDEDAavRAMAAYVDAGLTTFDCADIYG--PAEELIGEFRKRLRRERDAADDVQihtkwvP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 83 ENaSEMKMMLAC-----EKSLERLGVERLDLYLLHW-----EGHVpleETVEAFRDLVDEGMIARWGVSNLDLRAMEQLM 152
Cdd:cd19101 79 DP-GELTMTRAYveaaiDRSLKRLGVDRLDLVQFHWwdysdPGYL---DAAKHLAELQEEGKIRHLGLTNFDTERLREIL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 153 DieGGEDCAANQLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRGEL----LEQP------------------------ 204
Cdd:cd19101 155 D--AGVPIVSNQVQYSLLDRRPENGMAALCEDHGIKLLAYGTLAGGLLsekyLGVPeptgpaletrslqkyklmidewgg 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 946884465 205 ---------LIRDIANRHSASPAQVALAAVLRQDGVIA-IPKASSVEHVEANADALDIQFDLEDLERLDAA 265
Cdd:cd19101 233 wdlfqellrTLKAIADKHGVSIANVAVRWVLDQPGVAGvIVGARNSEHIDDNVRAFSFRLDDEDRAAIDAV 303
|
|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
5-264 |
1.82e-26 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 105.26 E-value: 1.82e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 5 VTFADGTTVPALGQGTWELGddpawRDEEQQALARGIDLGMTLIDTAELYGdgrSERLVGEVIAG-------RRDEVFLV 77
Cdd:cd19112 3 ITLNSGHKMPVIGLGVWRME-----PGEIKELILNAIKIGYRHFDCAADYK---NEKEVGEALAEafktglvKREDLFIT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 78 SKVRpeNASEMKMMLACEKSLERLGVERLDLYLLHW------------------------EGHVPLEETVEAFRDLVDEG 133
Cdd:cd19112 75 TKLW--NSDHGHVIEACKDSLKKLQLDYLDLYLVHFpvatkhtgvgttgsalgedgvldiDVTISLETTWHAMEKLVSAG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 134 MIARWGVSNLDLRAMEqlmdieggeDC--------AANQL-LYNLASRGvefDLFPWMQARDMPMMAYSPLGRG------ 198
Cdd:cd19112 153 LVRSIGISNYDIFLTR---------DClayskikpAVNQIeTHPYFQRD---SLVKFCQKHGISVTAHTPLGGAaanaew 220
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 199 ----ELLEQPLIRDIANRHSASPAQVALAAVLrQDGVIAIPKASSVEHVEANADALDIQFDLEDLERLDA 264
Cdd:cd19112 221 fgsvSPLDDPVLKDLAKKYGKSAAQIVLRWGI-QRNTAVIPKSSKPERLKENIDVFDFQLSKEDMKLIKS 289
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
11-265 |
3.21e-26 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 104.34 E-value: 3.21e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 11 TTVPALGQGTWELGDDPAW----------RDEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGR-RDEVFLVSK 79
Cdd:cd19103 2 KKLPKIALGTWSWGSGGAGgdqvfgnhldEDTLKAVFDKAMAAGLNLWDTAAVYGMGASEKILGEFLKRYpREDYIISTK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 80 VRPENASE----MKMMLacEKSLERLGVERLDLYLLHWEGHVP--LEETVeafrDLVDEGMIARWGVSNLDLRAMEQLMD 153
Cdd:cd19103 82 FTPQIAGQsadpVADML--EGSLARLGTDYIDIYWIHNPADVErwTPELI----PLLKSGKVKHVGVSNHNLAEIKRANE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 154 I--EGGEDCAANQLLYNLASRGVEFD-LFPWMQARDMPMMAYSPL-------------------GRGE----LLEQ---- 203
Cdd:cd19103 156 IlaKAGVSLSAVQNHYSLLYRSSEEAgILDYCKENGITFFAYMVLeqgalsgkydtkhplpegsGRAEtynpLLPQleel 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 946884465 204 -PLIRDIANRHSASPAQVALA-AVLRqdGVIAIPKASSVEHVEANADALDIQFDLEDLERLDAA 265
Cdd:cd19103 236 tAVMAEIGAKHGASIAQVAIAwAIAK--GTTPIIGVTKPHHVEDAARAASITLTDDEIKELEQL 297
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
2-263 |
3.55e-26 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 104.53 E-value: 3.55e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 2 TRLVTFADGTTVPALGQGTWELGDDpawrdEEQQALARGIDLGMTLIDTAELYGDgrsERLVGEVI-----AGR--RDEV 74
Cdd:cd19155 1 RNCVTFNNGEKMPVVGLGTWQSSPE-----EIETAVDTALEAGYRHIDTAYVYRN---EAAIGNVLkkwidSGKvkREEL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 75 FLVSKVRPENASEMKMMLACEKSLERLGVERLDLYLLHWEGHVPLEE----------------------TVEAFRDLVDE 132
Cdd:cd19155 73 FIVTKLPPGGNRREKVEKFLLKSLEKLQLDYVDLYLIHFPVGSLSKEddsgkldptgehkqdyttdlldIWKAMEAQVDQ 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 133 GMIARWGVSNLDLRAMEQLMDIEGGEDcAANQLLYNLASRgvEFDLFPWMQARDMPMMAYSPLG---------------- 196
Cdd:cd19155 153 GLTRSIGLSNFNREQMARILKNARIKP-ANLQVELHVYLQ--QKDLVDFCSTHSITVTAYAPLGspgaahfspgtgspsg 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 946884465 197 -RGELLEQPLIRDIANRHSASPAQVALAAVLrQDGVIAIPKASSVEHVEANADALDIQFDLEDLERLD 263
Cdd:cd19155 230 sSPDLLQDPVVKAIAERHGKSPAQVLLRWLM-QRGVVVIPKSTNAARIKENFQVFDFELTEADMAKLS 296
|
|
| AKR_AKR1C1-35 |
cd19108 |
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ... |
3-263 |
5.04e-26 |
|
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.
Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 103.85 E-value: 5.04e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 3 RLVTFADGTTVPALGQGTWELGDDPAWRDEEQQALArgIDLGMTLIDTAELYGDgrsERLVGEVI-----AG--RRDEVF 75
Cdd:cd19108 1 QRVKLNDGHFIPVLGFGTYAPEEVPKSKALEATKLA--IDAGFRHIDSAYLYQN---EEEVGQAIrskiaDGtvKREDIF 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 76 LVSKV-----RPEnasemkMMLAC-EKSLERLGVERLDLYLLHW-------EGHVPLEE-------------TVEAFRDL 129
Cdd:cd19108 76 YTSKLwctfhRPE------LVRPAlEKSLKKLQLDYVDLYLIHFpvalkpgEELFPKDEngklifdtvdlcaTWEAMEKC 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 130 VDEGMIARWGVSNLDLRAMEQLMDIEG---GEDCaaNQL---LYNLASRGVEFdlfpwMQARDMPMMAYSPLG--RGE-- 199
Cdd:cd19108 150 KDAGLAKSIGVSNFNRRQLEMILNKPGlkyKPVC--NQVechPYLNQSKLLDF-----CKSKDIVLVAYSALGsqRDKew 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 946884465 200 -------LLEQPLIRDIANRHSASPAQVALAAVLrQDGVIAIPKASSVEHVEANADALDIQFDLEDLERLD 263
Cdd:cd19108 223 vdqnspvLLEDPVLCALAKKHKRTPALIALRYQL-QRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKALD 292
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
14-259 |
5.45e-26 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 103.88 E-value: 5.45e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 14 PALGQGTWEL-GDDPAWrdEEQQALARG-IDLGMTLIDTAELYG--DGRSERLVGEVI----AGRRDEVFLVSKV----- 80
Cdd:cd19089 12 PAISLGLWHNfGDYTSP--EEARELLRTaFDLGITHFDLANNYGppPGSAEENFGRILkrdlRPYRDELVISTKAgygmw 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 81 -RP-ENASEMKMMLA-CEKSLERLGVERLDLYLLH-WEGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDI-- 154
Cdd:cd19089 90 pGPyGDGGSRKYLLAsLDQSLKRMGLDYVDIFYHHrYDPDTPLEETMTALADAVRSGKALYVGISNYPGAKARRAIALlr 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 155 EGGEDCAANQLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRGELLEQPLIRD-------------------------- 208
Cdd:cd19089 170 ELGVPLIIHQPRYSLLDRWAEDGLLEVLEEAGIGFIAFSPLAQGLLTDKYLNGIppdsrraaeskflteealtpekleql 249
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 946884465 209 -----IANRHSASPAQVALAAVLRQDGVI-AIPKASSVEHVEANADALD-IQFDLEDL 259
Cdd:cd19089 250 rklnkIAAKRGQSLAQLALSWVLRDPRVTsVLIGASSPSQLEDNVAALKnLDFSEEEL 307
|
|
| AKR_AKR3B1-3 |
cd19118 |
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ... |
9-264 |
9.65e-26 |
|
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.
Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 102.49 E-value: 9.65e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 9 DGTTVPALGQGTWElgddpAWRDEEQQALARGIDLGMTLIDTAELYGDGRS-----ERLVGEVIAGRRDEVFLVSKV--- 80
Cdd:cd19118 3 TGNKIPAIGLGTWQ-----AEPGEVGAAVKIALKAGYRHLDLAKVYQNQHEvgqalKELLKEEPGVKREDLFITSKLwnn 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 81 --RPENASEmkmmlACEKSLERLGVERLDLYLLHWEGH-------------------------VPLEETVEAFRDLVDEG 133
Cdd:cd19118 78 shRPEYVEP-----ALDDTLKELGLDYLDLYLIHWPVAfkptgdlnpltavptnggevdldlsVSLVDTWKAMVELKKTG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 134 MIARWGVSNLDLRAMEQLMDiEGGEDCAANQLLYN--LASRgvefDLFPWMQARDMPMMAYSPLGR---GE--LLEQPLI 206
Cdd:cd19118 153 KVKSIGVSNFSIDHLQAIIE-ETGVVPAVNQIEAHplLLQD----ELVDYCKSKNIHITAYSPLGNnlaGLplLVQHPEV 227
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 946884465 207 RDIANRHSASPAQVALAAVLrQDGVIAIPKASSVEHVEANADalDIQFDLEDLERLDA 264
Cdd:cd19118 228 KAIAAKLGKTPAQVLIAWGI-QRGHSVIPKSVTPSRIRSNFE--QVELSDDEFNAVTA 282
|
|
| AKR_AKR3C1 |
cd19119 |
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ... |
2-263 |
6.59e-25 |
|
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 100.65 E-value: 6.59e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 2 TRLVTFADGTTVPALGQGTWELGDDpawRDEEQQALARGIDLGMTLIDTAELYGdgrSERLVGEVIAG-------RRDEV 74
Cdd:cd19119 1 EISFKLNTGASIPALGLGTASPHED---RAEVKEAVEAAIKEGYRHIDTAYAYE---TEDFVGEAIKRaiddgsiKREEL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 75 FLVSKVRPENASEMKMMLacEKSLERLGVERLDLYLLHWEghVPL----EETVEAFRDLVDEGMIAR---------W--- 138
Cdd:cd19119 75 FITTKVWPTFYDEVERSL--DESLKALGLDYVDLLLVHWP--VCFekdsDDSGKPFTPVNDDGKTRYaasgdhittYkql 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 139 ------------GVSNLDLRAMEQLMDieggeDC----AANQLlyNLASRGVEFDLFPWMQARDMPMMAYSPLG--RGEL 200
Cdd:cd19119 151 ekiyldgrakaiGVSNYSIVYLERLIK-----ECkvvpAVNQV--ELHPHLPQMDLRDFCFKHGILVTAYSPLGshGAPN 223
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 946884465 201 LEQPLIRDIANRHSASPAQVALAAVLRQdGVIAIPKASSVEHVEANADAldIQFDLEDLERLD 263
Cdd:cd19119 224 LKNPLVKKIAEKYNVSTGDILISYHVRQ-GVIVLPKSLKPVRIVSNGKI--VSLTKEDLQKLD 283
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
20-263 |
2.11e-24 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 99.24 E-value: 2.11e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 20 TWelGDDPAWRDEEQQALARGIDLGMTLIDTAELYGDGR---SERLVGEVIAGR---RDEVFLVSK-----------VRP 82
Cdd:cd19077 16 TW--RPNPTPDEEAFETMKAALDAGSNLWNGGEFYGPPDphaNLKLLARFFRKYpeyADKVVLSVKggldpdtlrpdGSP 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 83 ENasemkMMLACEKSLERLG-VERLDLY-LLHWEGHVPLEETVEAFRDLVDEGMIARWGVSNLD---LRAMEQLMDIegg 157
Cdd:cd19077 94 EA-----VRKSIENILRALGgTKKIDIFePARVDPNVPIEETIKALKELVKEGKIRGIGLSEVSaetIRRAHAVHPI--- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 158 edcAANQLLYNLASRGVEF-DLFPWMQARDMPMMAYSPLGRG--------------------------ELLEQPL----- 205
Cdd:cd19077 166 ---AAVEVEYSLFSREIEEnGVLETCAELGIPIIAYSPLGRGlltgriksladipegdfrrhldrfngENFEKNLklvda 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 206 IRDIANRHSASPAQVALAAVLRQDG--VIAIPKASSVEHVEANADALDIQFDLEDLERLD 263
Cdd:cd19077 243 LQELAEKKGCTPAQLALAWILAQSGpkIIPIPGSTTLERVEENLKAANVELTDEELKEIN 302
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
14-251 |
1.18e-23 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 97.04 E-value: 1.18e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 14 PALGQGTWELGDDPAW-RDEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGR-RDEVFLVSKV----------- 80
Cdd:cd19162 1 PRLGLGAASLGNLARAgEDEAAATLDAAWDAGIRYFDTAPLYGLGLSERRLGAALARHpRAEYVVSTKVgrllepgaagr 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 81 -----RPENASEMKMMLACEKSLERLGVERLDLYLLHWEG---HVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLM 152
Cdd:cd19162 81 pagadRRFDFSADGIRRSIEASLERLGLDRLDLVFLHDPDrhlLQALTDAFPALEELRAEGVVGAIGVGVTDWAALLRAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 153 DiEGGEDCAANQLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRGELLE----------QPL----------IRDIANR 212
Cdd:cd19162 161 R-RADVDVVMVAGRYTLLDRRAATELLPLCAAKGVAVVAAGVFNSGILATddpagdrydyRPAtpevlararrLAAVCRR 239
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 946884465 213 HSASPAQVALAAVLRQDGVIAI-PKASSVEHVEANADALD 251
Cdd:cd19162 240 YGVPLPAAALQFPLRHPAVASVvVGAASPAELRDNLALLR 279
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
13-269 |
1.37e-23 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 98.00 E-value: 1.37e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 13 VPALGQGTWELGDDPAWRDEEQQ---ALARGIDLgmtlIDTAELY-------GDGRSERLVGEVIAGR--RDEVFLVSKV 80
Cdd:PRK10625 13 VSTLGLGTMTFGEQNSEADAHAQldyAVAQGINL----IDVAEMYpvpprpeTQGLTETYIGNWLAKRgsREKLIIASKV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 81 -----------RPENASEMK-MMLACEKSLERLGVERLDLYLLHWEGH------------------VPLEETVEAFRDLV 130
Cdd:PRK10625 89 sgpsrnndkgiRPNQALDRKnIREALHDSLKRLQTDYLDLYQVHWPQRptncfgklgyswtdsapaVSLLETLDALAEQQ 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 131 DEGMIARWGVSNLD----LRAMeQLMDIEGGEDCAANQLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRGEL------ 200
Cdd:PRK10625 169 RAGKIRYIGVSNETafgvMRYL-HLAEKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLAFGTLtgkyln 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 201 ----------LEQPLIR--------------DIANRHSASPAQVALAAVLRQDGVIA-IPKASSVEHVEANADALDIQFD 255
Cdd:PRK10625 248 gakpagarntLFSRFTRysgeqtqkavaayvDIAKRHGLDPAQMALAFVRRQPFVAStLLGATTMEQLKTNIESLHLTLS 327
|
330
....*....|....*....
gi 946884465 256 LEDLERLDAA-----FPPP 269
Cdd:PRK10625 328 EEVLAEIEAVhqvytYPAP 346
|
|
| AKR_AKR2B1-10 |
cd19113 |
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ... |
4-264 |
1.79e-23 |
|
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.
Pssm-ID: 381339 [Multi-domain] Cd Length: 310 Bit Score: 97.13 E-value: 1.79e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 4 LVTFADGTTVPALGQGTWELGDDPAwrdeeQQALARGIDLGMTLIDTAELYGDgrsERLVGEVIAG-------RRDEVFL 76
Cdd:cd19113 2 DIKLNSGYKMPSVGFGCWKLDNATA-----ADQIYQAIKAGYRLFDGAEDYGN---EKEVGEGVNRaideglvKREELFL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 77 VSKV-----RPENASemkmmLACEKSLERLGVERLDLYLLHW--------------------------EGHVPLEETVEA 125
Cdd:cd19113 74 TSKLwnnfhDPKNVE-----TALNKTLSDLKLDYVDLFLIHFpiafkfvpieekyppgfycgdgdnfvYEDVPILDTWKA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 126 FRDLVDEGMIARWGVSNLDLRAMEQLmdIEGGE-DCAANQL---LYNLASRGVEFdlfpwMQARDMPMMAYSPLG----- 196
Cdd:cd19113 149 LEKLVDAGKIKSIGVSNFPGALILDL--LRGATiKPAVLQIehhPYLQQPKLIEY-----AQKAGITITAYSSFGpqsfv 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 197 ---------RGELLEQPLIRDIANRHSASPAQVALAAVlRQDGVIAIPKASSVEHVEANADALDIQF---DLEDLERLDA 264
Cdd:cd19113 222 elnqgralnTPTLFEHDTIKSIAAKHNKTPAQVLLRWA-TQRGIAVIPKSNLPERLLQNLSVNDFDLtkeDFEEIAKLDI 300
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
14-260 |
1.13e-22 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 94.13 E-value: 1.13e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 14 PALGQGTWELGDDpawrdEEQQALARGIDLGMTLIDTAELYGDgrsERLVGEVIAG-------RRDEVFLVSKVRPENAS 86
Cdd:cd19128 2 PRLGFGTYKITES-----ESKEAVKNAIKAGYRHIDCAYYYGN---EAFIGIAFSEifkdggvKREDLFITSKLWPTMHQ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 87 EMKMMLACEKSLERLGVERLDLYLLHW--------------------EGHVPLEETVEAFRDLVDEGMIARWGVSNLDLR 146
Cdd:cd19128 74 PENVKEQLLITLQDLQLEYLDLFLIHWplafdmdtdgdprddnqiqsLSKKPLEDTWRAMEQCVDEKLTKNIGVSNYSTK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 147 AMEQLMDIeggedCA----ANQL---LYNLASRGVEFDLfpwmqARDMPMMAYSPLG------RGELLEQPLIRDIANRH 213
Cdd:cd19128 154 LLTDLLNY-----CKikpfMNQIechPYFQNDKLIKFCI-----ENNIHVTAYRPLGgsygdgNLTFLNDSELKALATKY 223
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 946884465 214 SASPAQVALAAVLRQ--DGVIAIPKASSVEHVEANADALDIQFDLEDLE 260
Cdd:cd19128 224 NTTPPQVIIAWHLQKwpKNYSVIPKSANKSRCQQNFDINDLALTKEDMD 272
|
|
| AKR_AKR2C1 |
cd19114 |
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ... |
10-263 |
1.77e-22 |
|
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 94.16 E-value: 1.77e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWELGDDpawrdEEQQALARGIDLGMTLIDTAELYGD----GRS-ERLVGEVIAgRRDEVFLVSKVRPEN 84
Cdd:cd19114 1 GDKMPLVGFGTAKIKAN-----ETEEVIYNAIKVGYRLIDGALLYGNeaevGRGiRKAIQEGLV-KREDLFIVTKLWNNF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 85 ASEMKMMLACEKSLERLGVERLDLYLLHWE--------------------------GHVPLEETVEAFRDLVDEGMIARW 138
Cdd:cd19114 75 HGKDHVREAFDRQLKDYGLDYIDLYLIHFPipaayvdpaenypflwkdkelkkfplEQSPMQECWREMEKLVDAGLVRNI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 139 GVSNLDLRAMEQLmdieggedcaanqLLYNLASRGV-EFDLFP---------WMQARDMPMMAYSPLGRG---------- 198
Cdd:cd19114 155 GIANFNVQLILDL-------------LTYAKIKPAVlQIEHHPylqqkrlidWAKKQGIQITAYSSFGNAvytkvtkhlk 221
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 946884465 199 ---ELLEQPLIRDIANRHSASPAQVALAAVLrQDGVIAIPKASSVEHVEANADALDIQFDLEDLERLD 263
Cdd:cd19114 222 hftNLLEHPVVKKLADKHKRDTGQVLLRWAV-QRNITVIPKSVNVERMKTNLDITSYKLDEEDMEALY 288
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
10-251 |
1.16e-21 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 91.84 E-value: 1.16e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWELGDDPAWRDEEQ--QALARGIDLGMTLIDTAELYGDGRSERLVGEVIAG-RRDEVFLVSKV-RPE-- 83
Cdd:cd19163 10 GLKVSKLGFGASPLGGVFGPVDEEEaiRTVHEALDSGINYIDTAPWYGQGRSETVLGKALKGiPRDSYYLATKVgRYGld 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 84 -----NASEMKMMLACEKSLERLGVERLDLYLLHWEGHVP-----LEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMD 153
Cdd:cd19163 90 pdkmfDFSAERITKSVEESLKRLGLDYIDIIQVHDIEFAPsldqiLNETLPALQKLKEEGKVRFIGITGYPLDVLKEVLE 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 154 IEGGE-DCAANQLLYNLASRGVEfDLFPWMQARDMPMMAYSPLGRGELLEQPL---------IRDIANRHSA-------S 216
Cdd:cd19163 170 RSPVKiDTVLSYCHYTLNDTSLL-ELLPFFKEKGVGVINASPLSMGLLTERGPpdwhpaspeIKEACAKAAAycksrgvD 248
|
250 260 270
....*....|....*....|....*....|....*.
gi 946884465 217 PAQVALAAVLRQDGVIA-IPKASSVEHVEANADALD 251
Cdd:cd19163 249 ISKLALQFALSNPDIATtLVGTASPENLRKNLEAAE 284
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
10-265 |
2.09e-21 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 91.50 E-value: 2.09e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWELGDDPAWRDEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAG---RRDEVFLVSKV------ 80
Cdd:cd19143 10 GLKVSALSFGSWVTFGNQVDVDEAKECMKAAYDAGVNFFDNAEVYANGQSEEIMGQAIKElgwPRSDYVVSTKIfwgggg 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 81 RPENA---SEMKMMLACEKSLERLGVERLDLYLLHW-EGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDI-- 154
Cdd:cd19143 90 PPPNDrglSRKHIVEGTKASLKRLQLDYVDLVFCHRpDPATPIEETVRAMNDLIDQGKAFYWGTSEWSAQQIEEAHEIad 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 155 -EGGEDCAANQLLYNLASRG-VEFDLFPWMQARDMPMMAYSPL----------------GRGELLEQPLIRD-------- 208
Cdd:cd19143 170 rLGLIPPVMEQPQYNLFHRErVEVEYAPLYEKYGLGTTTWSPLasglltgkynngipegSRLALPGYEWLKDrkeelgqe 249
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 209 ----------IANRHSASPAQVALAAVLRQDGV-IAIPKASSVEHVEANADALDI--QFDLEDLERLDAA 265
Cdd:cd19143 250 kiekvrklkpIAEELGCSLAQLAIAWCLKNPNVsTVITGATKVEQLEENLKALEVlpKLTPEVMEKIEAI 319
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
10-248 |
4.05e-21 |
|
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 90.21 E-value: 4.05e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTweLGDDPAwrdEEQQALARGIDLGMTLIDTAELYgdgRSERLVGEVI-----AG--RRDEVFLVSKVRP 82
Cdd:cd19129 3 SGAIPALGFGT--LIPDPS---ATRNAVKAALEAGFRHFDCAERY---RNEAEVGEAMqevfkAGkiRREDLFVTTKLWN 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 83 ENASEMKMMLACEKSLERLGVERLDLYLLH---------------------WEGHVPLEETVEAFRDLVDEGMIARWGVS 141
Cdd:cd19129 75 TNHRPERVKPAFEASLKRLQLDYLDLYLIHtpfafqpgdeqdprdangnviYDDGVTLLDTWRAMERLVDEGRCKAIGLS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 142 NLDLramEQLMDIegGEDCAANQLLYNLASRGV--EFDLFPWMQARDMPMMAYSPLGRG---ELLEQPLIRDIANRHSAS 216
Cdd:cd19129 155 DVSL---EKLREI--FEAARIKPAVVQVESHPYlpEWELLDFCKNHGIVLQAFAPLGHGmepKLLEDPVITAIARRVNKT 229
|
250 260 270
....*....|....*....|....*....|...
gi 946884465 217 PAQVALA-AVLRQDGVIAIPKASSveHVEANAD 248
Cdd:cd19129 230 PAQVLLAwAIQRGTALLTTSKTPS--RIRENFD 260
|
|
| AKR_AKR2D1 |
cd19115 |
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ... |
1-264 |
4.44e-21 |
|
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.
Pssm-ID: 381341 [Multi-domain] Cd Length: 311 Bit Score: 90.56 E-value: 4.44e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 1 MTRLVTFADGTTVPALGQGTWELGDDPAwRDEEQQAlargIDLGMTLIDTAELYGDgrsERLVGEVIAG-------RRDE 73
Cdd:cd19115 1 ASPTVKLNSGYDMPLVGFGLWKVNNDTC-ADQVYNA----IKAGYRLFDGACDYGN---EVEAGQGVARaikegivKRED 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 74 VFLVSKVRPENASEMKMMLACEKSLERLGVERLDLYLLH-------------------------WEGHVPLEETVEAFRD 128
Cdd:cd19115 73 LFIVSKLWNTFHDGERVEPICRKQLADWGIDYFDLFLIHfpialkyvdpavryppgwfydgkkvEFSNAPIQETWTAMEK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 129 LVDEGMIARWGVSNLdlrameqlmdieggedcaANQLLYNL--------ASRGVEF-------DLFPWMQARDMPMMAYS 193
Cdd:cd19115 153 LVDKGLARSIGVSNF------------------SAQLLMDLlryarirpATLQIEHhpyltqpRLVKYAQKEGIAVTAYS 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 194 ---PLGRGE-----------LLEQPLIRDIANRHSASPAQValaaVLR---QDGVIAIPKASSVEHVEANADALDIQFDL 256
Cdd:cd19115 215 sfgPQSFLEldlpgakdtppLFEHDVIKSIAEKHGKTPAQV----LLRwatQRGIAVIPKSNNPKRLAQNLDVTGFDLEA 290
|
....*...
gi 946884465 257 EDLERLDA 264
Cdd:cd19115 291 EEIKAISA 298
|
|
| AKR_AKR1D1-3 |
cd19109 |
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ... |
10-264 |
8.63e-21 |
|
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.
Pssm-ID: 381335 [Multi-domain] Cd Length: 308 Bit Score: 89.86 E-value: 8.63e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWElgdDP--AWRDEEQQALARGIDLGMTLIDTAELYgdgRSERLVGEVIAG-------RRDEVFLVSKV 80
Cdd:cd19109 1 GNSIPIIGLGTYS---EPktTPKGACAEAVKVAIDTGYRHIDGAYIY---QNEHEVGQAIREkiaegkvKREDIFYCGKL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 81 RPENASEMKMMLACEKSLERLGVERLDLYLLHW-------EGHVPLEE-------------TVEAFRDLVDEGMIARWGV 140
Cdd:cd19109 75 WNTCHPPELVRPTLERTLKVLQLDYVDLYIIEMpmafkpgDEIYPRDEngkwlyhktnlcaTWEALEACKDAGLVKSIGV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 141 SNLDLRAMEQLMDIEGgedcaanqLLYNLASRGVEF-------DLFPWMQARDMPMMAYSPLG--RGE---------LLE 202
Cdd:cd19109 155 SNFNRRQLELILNKPG--------LKHKPVSNQVEChpyftqpKLLEFCQQHDIVIVAYSPLGtcRDPiwvnvssppLLE 226
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 946884465 203 QPLIRDIANRHSASPAQVALAAVLrQDGVIAIPKASSVEHVEANADALDIQFDLEDLERLDA 264
Cdd:cd19109 227 DPLLNSIGKKYNKTAAQVVLRFNI-QRGVVVIPKSFNPERIKENFQIFDFSLTEEEMKDIEA 287
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
37-252 |
1.26e-20 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 88.35 E-value: 1.26e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 37 LARGIDLGMTLIDTAELYGDgrSERLVGEVIAgRRDEVFLVSKVRPENASEMK----MMLACEKSLERLGVERLDLYLLH 112
Cdd:cd19097 32 LEYALKAGINTLDTAPAYGD--SEKVLGKFLK-RLDKFKIITKLPPLKEDKKEdeaaIEASVEASLKRLKVDSLDGLLLH 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 113 WEGHVPL--EETVEAFRDLVDEGMIARWGVSnldLRAMEQLMDIEGGEDCAANQLLYN--------------LASRGVEF 176
Cdd:cd19097 109 NPDDLLKhgGKLVEALLELKKEGLIRKIGVS---VYSPEELEKALESFKIDIIQLPFNildqrflksgllakLKKKGIEI 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 177 dlfpwmQARdmpmmaySPLGRGELLEQPL---------------IRDIANRHSASPAQVALAAVLRQDG----VIAIpka 237
Cdd:cd19097 186 ------HAR-------SVFLQGLLLMEPDklpakfapakpllkkLHELAKKLGLSPLELALGFVLSLPEidkiVVGV--- 249
|
250
....*....|....*
gi 946884465 238 SSVEHVEANADALDI 252
Cdd:cd19097 250 DSLEQLKEIIAAFKK 264
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
10-260 |
1.67e-20 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 89.05 E-value: 1.67e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWE-LGDDPAWrdEEQQALARG-IDLGMTLIDTAELYGD--GRSE----RLVGEVIAGRRDEVFLVSKV- 80
Cdd:cd19150 9 GLKLPALSLGLWHnFGDDTPL--ETQRAILRTaFDLGITHFDLANNYGPppGSAEenfgRILREDFAGYRDELIISTKAg 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 81 -------RPENASEMKMMLACEKSLERLGVERLDLYLLH-WEGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLM 152
Cdd:cd19150 87 ydmwpgpYGEWGSRKYLLASLDQSLKRMGLDYVDIFYSHrFDPDTPLEETMGALDHAVRSGKALYVGISSYSPERTREAA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 153 DI--EGGEDCAANQLLYNLASRGVE-FDLFPWMQARDMPMMAYSPLGRGELLEQPL------------------------ 205
Cdd:cd19150 167 AIlrELGTPLLIHQPSYNMLNRWVEeSGLLDTLQELGVGCIAFTPLAQGLLTDKYLngipegsraskerslspkmltean 246
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 946884465 206 ------IRDIANRHSASPAQVALAAVLRQDGVI-AIPKASSVEHVEANADALD-IQFDLEDLE 260
Cdd:cd19150 247 lnsiraLNEIAQKRGQSLAQMALAWVLRDGRVTsALIGASRPEQLEENVGALDnLTFSADELA 309
|
|
| PRK10376 |
PRK10376 |
putative oxidoreductase; Provisional |
10-264 |
3.12e-20 |
|
putative oxidoreductase; Provisional
Pssm-ID: 236676 [Multi-domain] Cd Length: 290 Bit Score: 87.72 E-value: 3.12e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWELGDD-----PAWRDEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGRRDEVFLVSKV---R 81
Cdd:PRK10376 14 GRSVNRLGYGAMQLAGPgvfgpPKDRDAAIAVLREAVALGVNHIDTSDFYGPHVTNQLIREALHPYPDDLTIVTKVgarR 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 82 PENAS--------EMKMmlACEKSLERLGVERLDLYLLHWEG--HVP----LEETVEAFRDLVDEGMIARWGVSNLDLRA 147
Cdd:PRK10376 94 GEDGSwlpafspaELRR--AVHDNLRNLGLDVLDVVNLRLMGdgHGPaegsIEEPLTVLAELQRQGLVRHIGLSNVTPTQ 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 148 MEQ---LMDIEggedCAANQllYNLASRGVefDLFPWMQARD-MPMMAYSPLGRGELLEQPLIRDIANRHSASPAQVALA 223
Cdd:PRK10376 172 VAEarkIAEIV----CVQNH--YNLAHRAD--DALIDALARDgIAYVPFFPLGGFTPLQSSTLSDVAASLGATPMQVALA 243
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 946884465 224 AVL-RQDGVIAIPKASSVEHVEANADALDIQFDLEDLERLDA 264
Cdd:PRK10376 244 WLLqRSPNILLIPGTSSVAHLRENLAAAELVLSEEVLAELDG 285
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
10-260 |
6.56e-18 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 81.68 E-value: 6.56e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWELGDDPAWRDEEQQALARGIDLGMTLIDTAELYGD--GRSE----RLVGEVIAGRRDEVFLVSKVR-- 81
Cdd:cd19151 9 GLKLPAISLGLWHNFGDVDRYENSRAMLRRAFDLGITHFDLANNYGPppGSAEenfgRILKEDLKPYRDELIISTKAGyt 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 82 ----P--ENASEMKMMLACEKSLERLGVERLDLYLLHW-EGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDI 154
Cdd:cd19151 89 mwpgPygDWGSKKYLIASLDQSLKRMGLDYVDIFYHHRpDPETPLEETMGALDQIVRQGKALYVGISNYPPEEAREAAAI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 155 --EGGEDCAANQLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRG------------------------------ELLE 202
Cdd:cd19151 169 lkDLGTPCLIHQPKYSMFNRWVEEGLLDVLEEEGIGCIAFSPLAQGlltdrylngipedsraakgssflkpeqiteEKLA 248
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 946884465 203 Q-PLIRDIANRHSASPAQVALAAVLRQDGVI-AIPKASSVEHVEANADALD-IQFDLEDLE 260
Cdd:cd19151 249 KvRRLNEIAQARGQKLAQMALAWVLRNKRVTsVLIGASKPSQIEDAVGALDnREFSEEELA 309
|
|
| AKR_AKR15A |
cd19152 |
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ... |
14-250 |
4.26e-17 |
|
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 79.19 E-value: 4.26e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 14 PALGQGTWELGD--DPAWRDEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGR-RDEVFLVSKV----RPENAS 86
Cdd:cd19152 1 PKLGFGTAPLGNlyEAVSDEEAKATLVAAWDLGIRYFDTAPWYGAGLSEERLGAALRELgREDYVISTKVgrllVPLQEV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 87 EMKM--------------------MLAC-EKSLERLGVERLDLYLLH-------WEGHVPLEETV--EAFRDLV---DEG 133
Cdd:cd19152 81 EPTFepgfwnplpfdavfdysydgILRSiEDSLQRLGLSRIDLLSIHdpdedlaGAESDEHFAQAikGAFRALEelrEEG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 134 MIARWGVSNLDLRAMEQLMDiEGGEDC--AANQllYNLASRGVEFDLFPWMQARDMPMMAYSPLGRGELLEQPL------ 205
Cdd:cd19152 161 VIKAIGLGVNDWEVILRILE-EADLDWvmLAGR--YTLLDHSAARELLPECEKRGVKVVNAGPFNSGFLAGGDNfdyyey 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 946884465 206 -------------IRDIANRHSASPAQVALAAVLRQDGVIA-IPKASSVEHVEANADAL 250
Cdd:cd19152 238 gpappeliarrdrIEALCEQHGVSLAAAALQFALAPPAVASvAPGASSPERVEENVALL 296
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
10-263 |
1.04e-16 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 78.88 E-value: 1.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWELGDDPAWRDEEQQALARGIDLGMTLIDTAELYGD--GRSE----RLVGEVIAGRRDEVFLVSKVRPE 83
Cdd:PRK09912 22 GLRLPALSLGLWHNFGHVNALESQRAILRKAFDLGITHFDLANNYGPppGSAEenfgRLLREDFAAYRDELIISTKAGYD 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 84 -------NASEMKMMLAC-EKSLERLGVERLDLYLLHW-EGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDI 154
Cdd:PRK09912 102 mwpgpygSGGSRKYLLASlDQSLKRMGLEYVDIFYSHRvDENTPMEETASALAHAVQSGKALYVGISSYSPERTQKMVEL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 155 --EGGEDCAANQLLYNLASRGVE-FDLFPWMQARDMPMMAYSPLGRGELLEQ---------------------------- 203
Cdd:PRK09912 182 lrEWKIPLLIHQPSYNLLNRWVDkSGLLDTLQNNGVGCIAFTPLAQGLLTGKylngipqdsrmhregnkvrgltpkmlte 261
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 946884465 204 ------PLIRDIANRHSASPAQVALAAVLRQDGVIAI-PKASSVEHVEANADAL-DIQFDLEDLERLD 263
Cdd:PRK09912 262 anlnslRLLNEMAQQRGQSMAQMALSWLLKDERVTSVlIGASRAEQLEENVQALnNLTFSTEELAQID 329
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
44-267 |
1.05e-16 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 78.62 E-value: 1.05e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 44 GMTLIDTAELYGDGRSERLVGEVIAGR--RDEVFLVSK----VRPENASEMK----------MMLACEKSLERLGVERLD 107
Cdd:cd19146 48 GGNFIDTANNYQGEESERWVGEWMASRgnRDEMVLATKyttgYRRGGPIKIKsnyqgnhaksLRLSVEASLKKLQTSYID 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 108 LYLLH-WEGHVPLEETVEAFRDLVDEGMIARWGVSN----LDLRAMEQLMDiEGGEDCAANQLLYNLASRGVEFDLFPWM 182
Cdd:cd19146 128 ILYVHwWDYTTSIPELMQSLNHLVAAGKVLYLGVSDtpawVVSKANAYARA-HGLTQFVVYQGHWSAAFRDFERDILPMC 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 183 QARDMPMMAYSPLGRGELLEQPLIRD------------------------IANRHSASPAQVALAAVLRQDG-VIAIPKA 237
Cdd:cd19146 207 EAEGMALAPWGVLGQGQFRTEEEFKRrgrsgrkggpqtekerkvseklekVAEEKGTAITSVALAYVMHKAPyVFPIVGG 286
|
250 260 270
....*....|....*....|....*....|
gi 946884465 238 SSVEHVEANADALDIQFDLEDLERLDAAFP 267
Cdd:cd19146 287 RKVEHLKGNIEALGISLSDEEIQEIEDAYP 316
|
|
| AKR_AKR3E1 |
cd19122 |
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ... |
6-264 |
1.96e-16 |
|
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.
Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 77.28 E-value: 1.96e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 6 TFADGTTVPALGQGTWElgdDPAWRDEEQQALARGIDLGMTLIDTAELYgdgRSERLVGEVI--------AGRRDEVFLV 77
Cdd:cd19122 2 TLNNGVKIPAVGFGTFA---NEGAKGETYAAVTKALDVGYRHLDCAWFY---LNEDEVGDAVrdflkenpSVKREDLFIC 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 78 SKV-----RPENasemkMMLACEKSLERLGVERLDLYLLHW--------EGHVPL----------------EETVEAFRD 128
Cdd:cd19122 76 TKVwnhlhEPED-----VKWSIDNSLKNLKLDYIDLFLVHWpiaaekndQRSPKLgpdgkyvilkdltenpEPTWRAMEE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 129 LVDEGMIARWGVSNLDLRAMEQLMDIEGGEDcAANQLLYNLASRGVEfdLFPWMQARDMPMMAYSPLGR-------GELL 201
Cdd:cd19122 151 IYESGKAKAIGVSNWTIPGLKKLLSFAKVKP-HVNQIEIHPFLPNEE--LVDYCFSNDILPEAYSPLGSqnqvpstGERV 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 946884465 202 -EQPLIRDIANRHSASPAQVALAAVLRQdGVIAIPKASSVEHVEANADALDIQfDlEDLERLDA 264
Cdd:cd19122 228 sENPTLNEVAEKGGYSLAQVLIAWGLRR-GYVVLPKSSTPSRIESNFKSIELS-D-EDFEAINQ 288
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
14-253 |
8.03e-15 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 73.13 E-value: 8.03e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 14 PALGQGTWELGD--DPAWRDEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGR-RDEVFLVSKV----RPENAS 86
Cdd:cd19161 1 SELGLGTAGLGNlyTAVSNADADATLDAAWDSGIRYFDTAPMYGHGLAEHRLGDFLREKpRDEFVLSTKVgrllKPAREG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 87 EMK---------------------MMLACEKSLERLGVERLDLYLLHWEGHVPLEETVE-------------AFRDLVDE 132
Cdd:cd19161 81 SVPdpngfvdplpfeivydysydgIMRSFEDSLQRLGLNRIDILYVHDIGVYTHGDRKErhhfaqlmsggfkALEELKKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 133 GMIARWGVSNLDLRAMEQLMDiEGGEDCAANQLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRG-------------- 198
Cdd:cd19161 161 GVIKAFGLGVNEVQICLEALD-EADLDCFLLAGRYSLLDQSAEEEFLPRCEQRGTSLVIGGVFNSGilatgtksgakfny 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 946884465 199 -----ELLEQPL-IRDIANRHSASPAQVALAAVLRQDGVIAI-PKASSVEHVEANADALDIQ 253
Cdd:cd19161 240 gdapaEIISRVMeIEKICDAYNVPLAAAALQFPLRHPAVASVlTGARNPAQLRQNVEAFQTD 301
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
10-252 |
2.10e-13 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 68.72 E-value: 2.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWELGD---DPAWRDEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGR---RDEVFLVSKV--- 80
Cdd:cd19153 9 LGNVSPVGLGTAALGGvygDGLEQDEAVAIVAEAFAAGINHFDTSPYYGAESSEAVLGKALAALqvpRSSYTVATKVgry 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 81 RPE--NASEMKMMLACEKSLERLGVERLDLYLLHWEGHVP----LEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMD- 153
Cdd:cd19153 89 RDSefDYSAERVRASVATSLERLHTTYLDVVYLHDIEFVDydtlVDEALPALRTLKDEGVIKRIGIAGYPLDTLTRATRr 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 154 -IEGGEDCAANQLLYNLASRGVEFDLfPWMQARDMPMMAY-SPLGRGELLEQ------PLIRDIanRHSASPAQVALAAV 225
Cdd:cd19153 169 cSPGSLDAVLSYCHLTLQDARLESDA-PGLVRGAGPHVINaSPLSMGLLTSQgpppwhPASGEL--RHYAAAADAVCASV 245
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 946884465 226 LRQDGVIAIPKA--------------SSVEHVEANADALDI 252
Cdd:cd19153 246 EASLPDLALQYSlaahagvgtvllgpSSLAQLRSMLAAVDA 286
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
10-252 |
2.66e-12 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 65.88 E-value: 2.66e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWELGDDPAWRDEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAG---RRDEVFLVSKVRPENAS 86
Cdd:cd19158 10 GLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKkgwRRSSLVITTKIFWGGKA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 87 EMKMMLA-------CEKSLERLGVERLDLYLLHW-EGHVPLEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMDIEGGE 158
Cdd:cd19158 90 ETERGLSrkhiiegLKASLERLQLEYVDVVFANRpDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 159 DCA---ANQLLYNLASR-GVEFDLFPWMQARDMPMMAYSPL-----------------------------------GRGE 199
Cdd:cd19158 170 NLIppiCEQAEYHMFQReKVEVQLPELFHKIGVGAMTWSPLacgivsgkydsgippysraslkgyqwlkdkilseeGRRQ 249
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 946884465 200 LLEQPLIRDIANRHSASPAQVALAAVLRQDGVIAI-PKASSVEHVEANADALDI 252
Cdd:cd19158 250 QAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVlLGASNAEQLMENIGAIQV 303
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
10-252 |
4.08e-12 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 65.16 E-value: 4.08e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTW-----ELGDDPAwrdEEQQALArgIDLGMTLIDTAELYGDGRSERLVGEVI---AGRRDEVFLVSKV- 80
Cdd:cd19141 9 GLRVSCLGLGTWvtfgsQISDEVA---EELVTLA--YENGINLFDTAEVYAAGKAEIVLGKILkkkGWRRSSYVITTKIf 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 81 ---RPENA---SEMKMMLACEKSLERLGVERLDLYLLHW-EGHVPLEETVEAFRDLVDEGMIARWGVSNLDlrAMEqLMD 153
Cdd:cd19141 84 wggKAETErglSRKHIIEGLKASLERLQLEYVDIVFANRpDPNTPMEEIVRAFTHVINQGMAMYWGTSRWS--AME-IME 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 154 IEGgedcAANQllYNLASRGVEFDLFPWMQARDMPM-------------MAYSPLGRGELL------------------- 201
Cdd:cd19141 161 AYS----VARQ--FNLIPPIVEQAEYHLFQREKVEMqlpelfhkigvgaMTWSPLACGILSgkyddgvpeysraslkgyq 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 946884465 202 -------------EQPLIRD---IANRHSASPAQVALAAVLRQDGV-IAIPKASSVEHVEANADALDI 252
Cdd:cd19141 235 wlkekilseegrrQQAKLKElqiIADRLGCTLPQLAIAWCLKNEGVsSVLLGASSTEQLYENLQAIQV 302
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
10-252 |
1.06e-11 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 63.91 E-value: 1.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTW-----ELGDDPAwrdeeQQALARGIDLGMTLIDTAELYGDGRSERLVGEVI---AGRRDEVFLVSKVR 81
Cdd:cd19159 10 GLRVSCLGLGTWvtfggQISDEVA-----ERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIkkkGWRRSSLVITTKLY 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 82 PENASEMKMMLA-------CEKSLERLGVERLDLYLLHW-EGHVPLEETVEAFRDLVDEGMIARWGVSNLDlrAMEQLMD 153
Cdd:cd19159 85 WGGKAETERGLSrkhiiegLKGSLQRLQLEYVDVVFANRpDSNTPMEEIVRAMTHVINQGMAMYWGTSRWS--AMEIMEA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 154 IEGGEDC-----AANQLLYNLASR-GVEFDLFPWMQARDMPMMAYSPLGRGELL-------------------------- 201
Cdd:cd19159 163 YSVARQFnmippVCEQAEYHLFQReKVEVQLPELYHKIGVGAMTWSPLACGIISgkygngvpessraslkcyqwlkeriv 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 946884465 202 ------EQPLIRD---IANRHSASPAQVALAAVLRQDGVIAIPKASS-VEHVEANADALDI 252
Cdd:cd19159 243 seegrkQQNKLKDlspIAERLGCTLPQLAVAWCLRNEGVSSVLLGSStPEQLIENLGAIQV 303
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
10-141 |
2.05e-11 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 63.25 E-value: 2.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWELGDDPawrDEEQQA---LARGIDLGMTLIDTAELYGDGRSERLVGEVI---AGRRDEVFLVSKVRPE 83
Cdd:cd19142 10 GLRVSNVGLGTWSTFSTA---ISEEQAeeiVTLAYENGINYFDTSDAFTSGQAETELGRILkkkGWKRSSYIVSTKIYWS 86
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 946884465 84 NASE-----MKMMLAC-EKSLERLGVERLDLYLLH-WEGHVPLEETVEAFRDLVDEGMIARWGVS 141
Cdd:cd19142 87 YGSEerglsRKHIIESvRASLRRLQLDYIDIVIIHkADPMCPMEEVVRAMSYLIDNGLIMYWGTS 151
|
|
| AKR_AKR9A3_9B1-4 |
cd19147 |
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ... |
10-263 |
2.63e-11 |
|
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381373 [Multi-domain] Cd Length: 319 Bit Score: 62.92 E-value: 2.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWELGDdpAWR------DEEQ--QALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGR--RDEVFLVSK 79
Cdd:cd19147 7 GIRVSPLILGAMSIGD--AWSgfmgsmDKEQafELLDAFYEAGGNFIDTANNYQDEQSETWIGEWMKSRknRDQIVIATK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 80 V----------RPENA-----SEMKMMLACEKSLERLGVERLDLYLLH-WEGHVPLEETVEAFRDLVDEGMIARWGVSNL 143
Cdd:cd19147 85 FttdykayevgKGKAVnycgnHKRSLHVSVRDSLRKLQTDWIDILYVHwWDYTTSIEEVMDSLHILVQQGKVLYLGVSDT 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 144 D---LRAMEQLMDIEGGEDCAANQLLYNLASRGVEFDLFPWMQARDMPMMAYSPLGRGELLE-----------QPLIR-- 207
Cdd:cd19147 165 PawvVSAANYYATAHGKTPFSVYQGRWNVLNRDFERDIIPMARHFGMALAPWDVLGGGKFQSkkaveerkkngEGLRSfv 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 946884465 208 -----------------DIANRH-SASPAQVALAAVL-RQDGVIAIPKASSVEHVEANADALDIQFDLEDLERLD 263
Cdd:cd19147 245 ggteqtpeevkisealeKVAEEHgTESVTAIALAYVRsKAPNVFPLVGGRKIEHLKDNIEALSIKLTPEEIEYLE 319
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
10-252 |
3.96e-11 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 62.31 E-value: 3.96e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTW-----ELGDDPAwrdeeQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAG---RRDEVFLVSKVR 81
Cdd:cd19160 12 GLRVSCLGLGTWvtfgsQISDETA-----EDLLTVAYEHGVNLFDTAEVYAAGKAERTLGNILKSkgwRRSSYVVTTKIY 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 82 PENASEMKMMLA-------CEKSLERLGVERLDLYLLH-WEGHVPLEETVEAFRDLVDEGMIARWGVSNLDlrAMEQLMD 153
Cdd:cd19160 87 WGGQAETERGLSrkhiiegLRGSLDRLQLEYVDIVFANrSDPNSPMEEIVRAMTYVINQGMAMYWGTSRWS--AMEIMEA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 154 IEGGEDC-----AANQLLYNLASR-GVEFDLFPWMQARDMPMMAYSPLGRGELL-------------------------- 201
Cdd:cd19160 165 YSVARQFnlippVCEQAEYHLFQReKVEMQLPELYHKIGVGSVTWSPLACGLITgkydgrvpdtcraavkgyqwlkekvq 244
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 946884465 202 ------EQPLIRD---IANRHSASPAQVALAAVLRQDGVIAI-PKASSVEHVEANADALDI 252
Cdd:cd19160 245 seegkkQQAKVKElhpIADRLGCTVAQLAIAWCLRSEGVSSVlLGVSSAEQLIENLGSIQV 305
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
34-145 |
2.99e-10 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 59.60 E-value: 2.99e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 34 QQALARGIDLGMTLIDTAELYGDgrSERLVGEVIAGRRDE-----VFLVSKVRPE-----NASEMKMMLACEKSLERLGV 103
Cdd:cd19164 37 VDIVRRALELGIRAFDTSPYYGP--SEIILGRALKALRDEfprdtYFIITKVGRYgpddfDYSPEWIRASVERSLRRLHT 114
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 946884465 104 ERLDLYLLHWEGHVPLEETVEA---FRDLVDEGMIARWGVSNLDL 145
Cdd:cd19164 115 DYLDLVYLHDVEFVADEEVLEAlkeLFKLKDEGKIRNVGISGYPL 159
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
10-203 |
5.78e-07 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 49.78 E-value: 5.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 10 GTTVPALGQGTWELGD--DPAWRDEEQQALARGIDLGMTLIDTAELYGDGRSERLVGEVIAGR---RDEVFLVSK----V 80
Cdd:PLN02587 8 GLKVSSVGFGASPLGSvfGPVSEEDAIASVREAFRLGINFFDTSPYYGGTLSEKVLGKALKALgipREKYVVSTKcgryG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946884465 81 RPENASEMKMMLACEKSLERLGVERLDLYLLH--WEGHVP--LEETVEAFRDLVDEGMIARWGVSNLDLRAMEQLMD--I 154
Cdd:PLN02587 88 EGFDFSAERVTKSVDESLARLQLDYVDILHCHdiEFGSLDqiVNETIPALQKLKESGKVRFIGITGLPLAIFTYVLDrvP 167
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 946884465 155 EGGEDCAANQLLYNLASRGVEfDLFPWMQARDMPMMAYSPLGRGELLEQ 203
Cdd:PLN02587 168 PGTVDVILSYCHYSLNDSSLE-DLLPYLKSKGVGVISASPLAMGLLTEN 215
|
|
| AKR_unchar |
cd19098 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
205-268 |
2.14e-04 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381324 [Multi-domain] Cd Length: 318 Bit Score: 41.95 E-value: 2.14e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 946884465 205 LIRDIANRHSASPAQVALAAVLRQDGV-IAIPKASSVEHVEANADALDIQFDLEDLERL-DAAFPP 268
Cdd:cd19098 240 VLKAVADRLGVTPDALALAAVLAQPFVdVVLSGAATPEQLRSNLRALDVSLDLELLAALaDLAEPP 305
|
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