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Conserved domains on  [gi|948209549|ref|WP_056867311|]
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GNAT family N-acetyltransferase [Rathayibacter sp. Leaf296]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10006425)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate; similar to Escherichia coli uncharacterized protein YjdJ

CATH:  3.40.630.30
EC:  2.3.1.-|2.3.-.-
Gene Ontology:  GO:0008080|GO:0016746
PubMed:  10940244|9175471|15581578|27367672|26818562
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YidJ COG2388
Predicted acetyltransferase, GNAT superfamily [General function prediction only];
4-87 1.64e-26

Predicted acetyltransferase, GNAT superfamily [General function prediction only];


:

Pssm-ID: 441953 [Multi-domain]  Cd Length: 88  Bit Score: 92.91  E-value: 1.64e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948209549  4 DFRRVDDASRYELHQDGALVGVLDYRENDEAVSLVRSFTSPPFRGRGLAGELVAFAVDDIEtSSARRIVPLCWYVGQWFE 83
Cdd:COG2388   2 EITHNEEKGRFELEVDGELAGELTYRLEGGVIIITHTEVPPALRGQGIASALVEAALDDAR-ERGLKVVPLCPFVAAYFE 80


                ....
gi 948209549 84 EHPE 87
Cdd:COG2388  81 RHPE 84
 
Name Accession Description Interval E-value
YidJ COG2388
Predicted acetyltransferase, GNAT superfamily [General function prediction only];
4-87 1.64e-26

Predicted acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 441953 [Multi-domain]  Cd Length: 88  Bit Score: 92.91  E-value: 1.64e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948209549  4 DFRRVDDASRYELHQDGALVGVLDYRENDEAVSLVRSFTSPPFRGRGLAGELVAFAVDDIEtSSARRIVPLCWYVGQWFE 83
Cdd:COG2388   2 EITHNEEKGRFELEVDGELAGELTYRLEGGVIIITHTEVPPALRGQGIASALVEAALDDAR-ERGLKVVPLCPFVAAYFE 80


                ....
gi 948209549 84 EHPE 87
Cdd:COG2388  81 RHPE 84
Acetyltransf_CG pfam14542
GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both ...
 13-91 1.40e-22

GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.


Pssm-ID: 434030 [Multi-domain]  Cd Length: 79  Bit Score: 82.95  E-value: 1.40e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948209549  13 RYELHQDG-ALVGVLDYRENDEAVSLVRSFTSPPFRGRGLAGELVAFAVDDIETSSaRRIVPLCWYVGQWFEEHPEKSHL 91
Cdd:pfam14542  1 RFEIRVDGgAEVAFLTYRRGDGVLIITHTEVPPALRGQGIASKLVKAALDDAREEG-LKIVPLCSYVAAYLEKHPEYADL 79
 
Name Accession Description Interval E-value
YidJ COG2388
Predicted acetyltransferase, GNAT superfamily [General function prediction only];
4-87 1.64e-26

Predicted acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 441953 [Multi-domain]  Cd Length: 88  Bit Score: 92.91  E-value: 1.64e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948209549  4 DFRRVDDASRYELHQDGALVGVLDYRENDEAVSLVRSFTSPPFRGRGLAGELVAFAVDDIEtSSARRIVPLCWYVGQWFE 83
Cdd:COG2388   2 EITHNEEKGRFELEVDGELAGELTYRLEGGVIIITHTEVPPALRGQGIASALVEAALDDAR-ERGLKVVPLCPFVAAYFE 80


                ....
gi 948209549 84 EHPE 87
Cdd:COG2388  81 RHPE 84
Acetyltransf_CG pfam14542
GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both ...
 13-91 1.40e-22

GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.


Pssm-ID: 434030 [Multi-domain]  Cd Length: 79  Bit Score: 82.95  E-value: 1.40e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948209549  13 RYELHQDG-ALVGVLDYRENDEAVSLVRSFTSPPFRGRGLAGELVAFAVDDIETSSaRRIVPLCWYVGQWFEEHPEKSHL 91
Cdd:pfam14542  1 RFEIRVDGgAEVAFLTYRRGDGVLIITHTEVPPALRGQGIASKLVKAALDDAREEG-LKIVPLCSYVAAYLEKHPEYADL 79
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
16-72 2.35e-04

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 37.09  E-value: 2.35e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 948209549  16 LHQDGALVGVLD-YRENDEAVSLVRSFTSPPFRGRGLAGELVAFAVDDIETSSARRIV 72
Cdd:COG2153   39 AYDDGELVATARlLPPGDGEAKIGRVAVLPEYRGQGLGRALMEAAIEEARERGARRIV 96
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 18-71 1.07e-03

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 35.35  E-value: 1.07e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 948209549  18 QDGALVGVLDYRENDEAVSLVRS-FTSPPFRGRGLAGELVAFAVDDIETSSARRI 71
Cdd:COG1246   35 EDGEIVGCAALHPLDEDLAELRSlAVHPDYRGRGIGRRLLEALLAEARELGLKRL 89
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
41-72 9.46e-03

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 32.19  E-value: 9.46e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 948209549 41 FTSPPFRGRGLAGELVAFAVDDIETSSARRIV 72
Cdd:COG3393  22 YTHPEYRGRGLASALVAALAREALARGARTPF 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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