|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
19-302 |
1.02e-120 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 348.00 E-value: 1.02e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 19 SPLCLGAAPLGDMPEtfqySTSEEQALVTLRTAFESPINFIDTAAAYGEgeSERRIGKAIQANGglPAGYVLATKADRDF 98
Cdd:cd19090 1 SALGLGTAGLGGVFG----GVDDDEAVATIRAALDLGINYIDTAPAYGD--SEERLGLALAELP--REPLVLSTKVGRLP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 99 -KTGDFSGEQIKRSIEGSLERLGLDHLQYVYIHDPENTTFENVMGSGGPLEVLQKFQEQGVIDHIGISGGPIDMLIRYVE 177
Cdd:cd19090 73 eDTADYSADRVRRSVEESLERLGRDRIDLLMIHDPERVPWVDILAPGGALEALLELKEEGLIKHIGLGGGPPDLLRRAIE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 178 TGAFSAVETHNRYTLLNR-AAEPLLDVASRRDVAVINAAPYGSGILAKGPDAYARYAYSDAPPIVLERARMYAKVCQEYN 256
Cdd:cd19090 153 TGDFDVVLTANRYTLLDQsAADELLPAAARHGVGVINASPLGMGLLAGRPPERVRYTYRWLSPELLDRAKRLYELCDEHG 232
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 950277055 257 VPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELANYPIAPELW 302
Cdd:cd19090 233 VPLPALALRFLLRDPRISTVLVGASSPEELEQNVAAAEGPLPEELW 278
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
9-301 |
1.41e-78 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 241.30 E-value: 1.41e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 9 RPLGSTGLLISPLCLGAAPLGDMpetFQySTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQangGLP-AG 87
Cdd:cd19163 4 RKLGKTGLKVSKLGFGASPLGGV---FG-PVDEEEAIRTVHEALDSGINYIDTAPWYGQGRSETVLGKALK---GIPrDS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 88 YVLATKADR----DFKTGDFSGEQIKRSIEGSLERLGLDHLQYVYIHDPE-NTTFENVMGSGgpLEVLQKFQEQGVIDHI 162
Cdd:cd19163 77 YYLATKVGRygldPDKMFDFSAERITKSVEESLKRLGLDYIDIIQVHDIEfAPSLDQILNET--LPALQKLKEEGKVRFI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 163 GISGGPIDMLIRYVE--TGAFSAVETHNRYTLLNRAAEPLLDVASRRDVAVINAAPYGSGILA-KGPDAYARyaysdAPP 239
Cdd:cd19163 155 GITGYPLDVLKEVLErsPVKIDTVLSYCHYTLNDTSLLELLPFFKEKGVGVINASPLSMGLLTeRGPPDWHP-----ASP 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 950277055 240 IVLERARMYAKVCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELANYPIAPEL 301
Cdd:cd19163 230 EIKEACAKAAAYCKSRGVDISKLALQFALSNPDIATTLVGTASPENLRKNLEAAEEPLDAHL 291
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
21-304 |
1.22e-77 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 238.80 E-value: 1.22e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 21 LCLGAAPLGDMPETfqystSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQanGGLPAGYVLATKADRDFKT 100
Cdd:cd19162 3 LGLGAASLGNLARA-----GEDEAAATLDAAWDAGIRYFDTAPLYGLGLSERRLGAALA--RHPRAEYVVSTKVGRLLEP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 101 G------------DFSGEQIKRSIEGSLERLGLDHLQYVYIHDPENTTFEnvmGSGGPLEVLQKFQEQGVIDHIGISGGP 168
Cdd:cd19162 76 GaagrpagadrrfDFSADGIRRSIEASLERLGLDRLDLVFLHDPDRHLLQ---ALTDAFPALEELRAEGVVGAIGVGVTD 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 169 IDMLIRYVETGAFSAVETHNRYTLLNR-AAEPLLDVASRRDVAVINAAPYGSGILAKGPDAYARYAYSDAPPIVLERARM 247
Cdd:cd19162 153 WAALLRAARRADVDVVMVAGRYTLLDRrAATELLPLCAAKGVAVVAAGVFNSGILATDDPAGDRYDYRPATPEVLARARR 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 950277055 248 YAKVCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELANYPIAPELWSA 304
Cdd:cd19162 233 LAAVCRRYGVPLPAAALQFPLRHPAVASVVVGAASPAELRDNLALLRTPIPAEFWAE 289
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
8-315 |
2.82e-75 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 233.53 E-value: 2.82e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 8 KRPLGSTGLLISPLCLGAAPLGDMPETfqysTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQanGGLPAG 87
Cdd:COG0667 3 YRRLGRSGLKVSRLGLGTMTFGGPWGG----VDEAEAIAILDAALDAGINFFDTADVYGPGRSEELLGEALK--GRPRDD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 88 YVLATKADRDFKTG----DFSGEQIKRSIEGSLERLGLDHLQYVYIHDPE-NTTFENVMGsggpleVLQKFQEQGVIDHI 162
Cdd:COG0667 77 VVIATKVGRRMGPGpngrGLSREHIRRAVEASLRRLGTDYIDLYQLHRPDpDTPIEETLG------ALDELVREGKIRYI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 163 GISGGPIDMLIRYVETGA----FSAVEthNRYTLLNRAAE-PLLDVASRRDVAVINAAPYGSGILAKGPDAYARYAYSD- 236
Cdd:COG0667 151 GVSNYSAEQLRRALAIAEglppIVAVQ--NEYSLLDRSAEeELLPAARELGVGVLAYSPLAGGLLTGKYRRGATFPEGDr 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 237 ---------APPIVLERARMYAKVCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELANYPIAPELWSAFDA 307
Cdd:COG0667 229 aatnfvqgyLTERNLALVDALRAIAAEHGVTPAQLALAWLLAQPGVTSVIPGARSPEQLEENLAAADLELSAEDLAALDA 308
|
....*...
gi 950277055 308 IGYDTEDP 315
Cdd:COG0667 309 ALAAVPAP 316
|
|
| AKR_AKR15A |
cd19152 |
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ... |
19-304 |
2.00e-68 |
|
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 215.94 E-value: 2.00e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 19 SPLCLGAAPLGDMPEtfqySTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQANGglPAGYVLATKADR-- 96
Cdd:cd19152 1 PKLGFGTAPLGNLYE----AVSDEEAKATLVAAWDLGIRYFDTAPWYGAGLSEERLGAALRELG--REDYVISTKVGRll 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 97 --------DFKTG-----------DFSGEQIKRSIEGSLERLGLDHLQYVYIHDPENTT--------FENVMGSGGPleV 149
Cdd:cd19152 75 vplqevepTFEPGfwnplpfdavfDYSYDGILRSIEDSLQRLGLSRIDLLSIHDPDEDLagaesdehFAQAIKGAFR--A 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 150 LQKFQEQGVIDHIGISGGPIDMLIRYVETGAFSAVETHNRYTLLN-RAAEPLLDVASRRDVAVINAAPYGSGILAkGPDA 228
Cdd:cd19152 153 LEELREEGVIKAIGLGVNDWEVILRILEEADLDWVMLAGRYTLLDhSAARELLPECEKRGVKVVNAGPFNSGFLA-GGDN 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 950277055 229 YARYAYSDAPPIVLERARMYAKVCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELANYPIAPELWSA 304
Cdd:cd19152 232 FDYYEYGPAPPELIARRDRIEALCEQHGVSLAAAALQFALAPPAVASVAPGASSPERVEENVALLATEIPAAFWEE 307
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
19-305 |
5.57e-62 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 199.47 E-value: 5.57e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 19 SPLCLGAAPLGDMpetfqY-STSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQANGglPAGYVLATKADRD 97
Cdd:cd19161 1 SELGLGTAGLGNL-----YtAVSNADADATLDAAWDSGIRYFDTAPMYGHGLAEHRLGDFLREKP--RDEFVLSTKVGRL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 98 FK---------------------TGDFSGEQIKRSIEGSLERLGLDHLQYVYIHD---------PENTTFENVMGSGgpL 147
Cdd:cd19161 74 LKparegsvpdpngfvdplpfeiVYDYSYDGIMRSFEDSLQRLGLNRIDILYVHDigvythgdrKERHHFAQLMSGG--F 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 148 EVLQKFQEQGVIDHIGISGGPIDMLIRYVETGAFSAVETHNRYTLLNRAA-EPLLDVASRRDVAVINAAPYGSGILAKGP 226
Cdd:cd19161 152 KALEELKKAGVIKAFGLGVNEVQICLEALDEADLDCFLLAGRYSLLDQSAeEEFLPRCEQRGTSLVIGGVFNSGILATGT 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 950277055 227 DAYARYAYSDAPPIVLERARMYAKVCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELANYPIAPELWSAF 305
Cdd:cd19161 232 KSGAKFNYGDAPAEIISRVMEIEKICDAYNVPLAAAALQFPLRHPAVASVLTGARNPAQLRQNVEAFQTDIPEELWQAL 310
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
9-308 |
5.62e-52 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 173.81 E-value: 5.62e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 9 RPLGSTGLLISPLCLGAAPLGDMpetFQYsTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQANGGLPAGY 88
Cdd:PLN02587 2 RELGSTGLKVSSVGFGASPLGSV---FGP-VSEEDAIASVREAFRLGINFFDTSPYYGGTLSEKVLGKALKALGIPREKY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 89 VLATKADRDFKTGDFSGEQIKRSIEGSLERLGLDHLQYVYIHDPENTTFENVMGSGGPleVLQKFQEQGVIDHIGISGGP 168
Cdd:PLN02587 78 VVSTKCGRYGEGFDFSAERVTKSVDESLARLQLDYVDILHCHDIEFGSLDQIVNETIP--ALQKLKESGKVRFIGITGLP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 169 IDMLiRYV----ETGAFSAVETHNRYTLLNRAAEPLLDVASRRDVAVINAAPYGSGILA-KGPDayaryAYSDAPPIVLE 243
Cdd:PLN02587 156 LAIF-TYVldrvPPGTVDVILSYCHYSLNDSSLEDLLPYLKSKGVGVISASPLAMGLLTeNGPP-----EWHPAPPELKS 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 950277055 244 RARMYAKVCQEYNVPLAAAALQFSLRDLRIASTVVGMSKP----ERVAQTIELANYPIAPELWSAFDAI 308
Cdd:PLN02587 230 ACAAAATHCKEKGKNISKLALQYSLSNKDISTTLVGMNSVqqveENVAAATELETSGIDEELLSEVEAI 298
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
21-308 |
4.92e-51 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 170.57 E-value: 4.92e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 21 LCLGAAPLGDMPETFqystSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQANGGLPAGYVLATKADRDFKT 100
Cdd:pfam00248 1 IGLGTWQLGGGWGPI----SKEEALEALRAALEAGINFIDTAEVYGDGKSEELLGEALKDYPVKRDKVVIATKVPDGDGP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 101 GDFSG--EQIKRSIEGSLERLGLDHLQYVYIHDPE-NTTFENVMGsggpleVLQKFQEQGVIDHIGISGGPIDmLIRYVE 177
Cdd:pfam00248 77 WPSGGskENIRKSLEESLKRLGTDYIDLYYLHWPDpDTPIEETWD------ALEELKKEGKIRAIGVSNFDAE-QIEKAL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 178 TGA---FSAVEthNRYTLLNRAAEP-LLDVASRRDVAVINAAPYGSGILAKG-------PDAYARYAYSDAPPIVLERAR 246
Cdd:pfam00248 150 TKGkipIVAVQ--VEYNLLRRRQEEeLLEYCKKNGIPLIAYSPLGGGLLTGKytrdpdkGPGERRRLLKKGTPLNLEALE 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 950277055 247 MYAKVCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELANYPIAPELWSAFDAI 308
Cdd:pfam00248 228 ALEEIAKEHGVSPAQVALRWALSKPGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDEL 289
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
8-291 |
3.98e-48 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 161.11 E-value: 3.98e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 8 KRPLGSTGLLISPLCLGAAPLGDMPEtfqystseEQALVTLRTAFESPINFIDTAAAYGEgeSERRIGKAIQANGGlpaG 87
Cdd:cd19100 1 YRRLGRTGLKVSRLGFGGGPLGRLSQ--------EEAAAIIRRALDLGINYFDTAPSYGD--SEEKIGKALKGRRD---K 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 88 YVLATKadrdfkTGDFSGEQIKRSIEGSLERLGLDHLQYVYIHDPEN-TTFENVMGSGGPLEVLQKFQEQGVIDHIGISG 166
Cdd:cd19100 68 VFLATK------TGARDYEGAKRDLERSLKRLGTDYIDLYQLHAVDTeEDLDQVFGPGGALEALLEAKEEGKIRFIGISG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 167 GPIDMLIRYVETGAFSAVETH-NR-YTLLNRAAEPLLDVASRRDVAVINAAPYGSGILAKGpdayaryaysdappivler 244
Cdd:cd19100 142 HSPEVLLRALETGEFDVVLFPiNPaGDHIDSFREELLPLAREKGVGVIAMKVLAGGRLLSG------------------- 202
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 950277055 245 armyakvcqeyNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIE 291
Cdd:cd19100 203 -----------DPLDPEQALRYALSLPPVDVVIVGMDSPEELDENLA 238
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
16-288 |
5.01e-48 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 161.11 E-value: 5.01e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 16 LLISPLCLGAAPLGdmpETFQYSTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQANGGLPagyVLATKAD 95
Cdd:cd19086 1 LEVSEIGFGTWGLG---GDWWGDVDDAEAIRALRAALDLGINFFDTADVYGDGHSERLLGKALKGRRDKV---VIATKFG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 96 RDFKTG-----DFSGEQIKRSIEGSLERLGLDHLQYVYIHDPenttFENVMGSGGPLEVLQKFQEQGVIDHIGISGGPID 170
Cdd:cd19086 75 NRFDGGperpqDFSPEYIREAVEASLKRLGTDYIDLYQLHNP----PDEVLDNDELFEALEKLKQEGKIRAYGVSVGDPE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 171 MLIRYVETGAFSAVEThnRYTLLNRAAE-PLLDVASRRDVAVINAAPYGSGILA-Kgpdayaryaysdappivlerarmy 248
Cdd:cd19086 151 EALAALRRGGIDVVQV--IYNLLDQRPEeELFPLAEEHGVGVIARVPLASGLLTgK------------------------ 204
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 950277055 249 akvcqeynvpLAAAALQFSLRDLRIASTVVGMSKPERVAQ 288
Cdd:cd19086 205 ----------LAQAALRFILSHPAVSTVIPGARSPEQVEE 234
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
6-293 |
1.14e-46 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 157.75 E-value: 1.14e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 6 LSKRPLGSTGLLISPLCLGAAPLGDmpetfqystsEEQALVtlRTAFESPINFIDTAAAYGEGESERRIGKAIQANGglP 85
Cdd:cd19105 1 MPYRTLGKTGLKVSRLGFGGGGLPR----------ESPELL--RRALDLGINYFDTAEGYGNGNSEEIIGEALKGLR--R 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 86 AGYVLATKAdrDFKTGDFSGEQIKRSIEGSLERLGLDHLQYVYIHDPENTtfENVMGSGGPLEVLQKFQEQGVIDHIGIS 165
Cdd:cd19105 67 DKVFLATKA--SPRLDKKDKAELLKSVEESLKRLQTDYIDIYQLHGVDTP--EERLLNEELLEALEKLKKEGKVRFIGFS 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 166 --GGPIDMLIRYVETGAFSAVEThnRYTLLNRAAE--PLLDVASRRDVAVINAAPYGSGILAKGPDAYARyaysdAPPIv 241
Cdd:cd19105 143 thDNMAEVLQAAIESGWFDVIMV--AYNFLNQPAEleEALAAAAEKGIGVVAMKTLAGGYLQPALLSVLK-----AKGF- 214
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 950277055 242 lerarmyakvcqeynvPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELA 293
Cdd:cd19105 215 ----------------SLPQAALKWVLSNPRVDTVVPGMRNFAELEENLAAA 250
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
19-291 |
1.81e-46 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 157.40 E-value: 1.81e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 19 SPLCLGAAPLGDMPETFqystSEEQALVTLRTAFESPINFIDTAAAYGEgeSERRIGKAIQanGGLPAGYVLATKA---- 94
Cdd:cd19095 1 SVLGLGTSGIGRVWGVP----SEAEAARLLNTALDLGINLIDTAPAYGR--SEERLGRALA--GLRRDDLFIATKVgthg 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 95 DRDFKTGDFSGEQIKRSIEGSLERLGLDHLQYVYIHDPENTTFENVMgsggpLEVLQKFQEQGVIDHIGISGGPIDmLIR 174
Cdd:cd19095 73 EGGRDRKDFSPAAIRASIERSLRRLGTDYIDLLQLHGPSDDELTGEV-----LETLEDLKAAGKVRYIGVSGDGEE-LEA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 175 YVETGAFSAVETHnrYTLLNRAAEPLLDVASRRdvavinaapyGSGILAKGPDAYARYAYSDAPPIVLERARMYAKVCQE 254
Cdd:cd19095 147 AIASGVFDVVQLP--YNVLDREEEELLPLAAEA----------GLGVIVNRPLANGRLRRRVRRRPLYADYARRPEFAAE 214
|
250 260 270
....*....|....*....|....*....|....*...
gi 950277055 255 YNVPLAA-AALQFSLRDLRIASTVVGMSKPERVAQTIE 291
Cdd:cd19095 215 IGGATWAqAALRFVLSHPGVSSAIVGTTNPEHLEENLA 252
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
15-306 |
1.55e-45 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 156.53 E-value: 1.55e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 15 GLLISPLCLGAAPLGDmpeTFQYSTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQangglpaGY----VL 90
Cdd:cd19084 1 DLKVSRIGLGTWAIGG---TWWGEVDDQESIEAIKAAIDLGINFFDTAPVYGFGHSEEILGKALK-------GRrddvVI 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 91 ATK-----ADRDFKTGDFSGEQIKRSIEGSLERLGLDHLQYVYIHDP-ENTTFENVMgsggplEVLQKFQEQGVIDHIGI 164
Cdd:cd19084 71 ATKcglrwDGGKGVTKDLSPESIRKEVEQSLRRLQTDYIDLYQIHWPdPNTPIEETA------EALEKLKKEGKIRYIGV 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 165 SGGPIDMLIRYVETGAFSAVETHnrYTLLNRAAE-PLLDVASRRDVAVInaaPYGS---GILA----KGP-----DAYAR 231
Cdd:cd19084 145 SNFSVEQLEEARKYGPIVSLQPP--YSMLEREIEeELLPYCRENGIGVL---PYGPlaqGLLTgkykKEPtfppdDRRSR 219
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 950277055 232 YAYSDAP--PIVLERARMYAKVCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELANYPIAPELWSAFD 306
Cdd:cd19084 220 FPFFRGEnfEKNLEIVDKLKEIAEKYGKSLAQLAIAWTLAQPGVTSAIVGAKNPEQLEENAGALDWELTEEELKEID 296
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
8-308 |
1.73e-44 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 155.36 E-value: 1.73e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 8 KRPLGSTGLLISPLCLGAaplgdMPetFQYsTSEEQALVTLRTAFESPINFIDTAAAYgeGESERRIGKAIQangGLPAG 87
Cdd:COG1453 3 YRRLGKTGLEVSVLGFGG-----MR--LPR-KDEEEAEALIRRAIDNGINYIDTARGY--GDSEEFLGKALK---GPRDK 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 88 YVLATKADRDFKTgdfsGEQIKRSIEGSLERLGLDHLQYVYIH---DPEntTFENVMGSGGPLEVLQKFQEQGVIDHIGI 164
Cdd:COG1453 70 VILATKLPPWVRD----PEDMRKDLEESLKRLQTDYIDLYLIHglnTEE--DLEKVLKPGGALEALEKAKAEGKIRHIGF 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 165 SG-GPIDMLIRYVETGAFSAVETHnrYTLL---NRAAEPLLDVASRRDVAVINAAPYGSGILAKGPDAYARYAYSDAPPi 240
Cdd:COG1453 144 SThGSLEVIKEAIDTGDFDFVQLQ--YNYLdqdNQAGEEALEAAAEKGIGVIIMKPLKGGRLANPPEKLVELLCPPLSP- 220
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 241 vlerarmyakvcqeynvplAAAALQFSLRDLRIASTVVGMSKPERVAQTIELAN--YPIAPELWSAFDAI 308
Cdd:COG1453 221 -------------------AEWALRFLLSHPEVTTVLSGMSTPEQLDENLKTADnlEPLTEEELAILERL 271
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
8-309 |
1.64e-43 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 151.65 E-value: 1.64e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 8 KRPLGSTGLLISPLCLGAAPLGD-MPETfqystSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQangGLPA 86
Cdd:cd19104 2 YRRFGRTGLKVSELTFGGGGIGGlMGRT-----TREEQIAAVRRALDLGINFFDTAPSYGDGKSEENLGRALK---GLPA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 87 GYVLATKAD-RDFKTGDFSGeQIKRSIEGSLERLGLDHLQYVYIHD----------PENTTFENVMGSGGPLEVLQKFQE 155
Cdd:cd19104 74 GPYITTKVRlDPDDLGDIGG-QIERSVEKSLKRLKRDSVDLLQLHNrigderdkpvGGTLSTTDVLGLGGVADAFERLRS 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 156 QGVIDHIGISG-GPIDMLIRYVETGAFSAVETHnrYTLLN-----------RAAEP--LLDVASRRDVAVINAAPYGSGI 221
Cdd:cd19104 153 EGKIRFIGITGlGNPPAIRELLDSGKFDAVQVY--YNLLNpsaaearprgwSAQDYggIIDAAAEHGVGVMGIRVLAAGA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 222 LA------KGPDAYARYAYSdappIVLERARMYAKVCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELANY 295
Cdd:cd19104 231 LTtsldrgREAPPTSDSDVA----IDFRRAAAFRALAREWGETLAQLAHRFALSNPGVSTVLVGVKNREELEEAVAAEAA 306
|
330
....*....|....*
gi 950277055 296 -PIAPELWSAFDAIG 309
Cdd:cd19104 307 gPLPAENLARLEALW 321
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
28-294 |
1.79e-42 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 147.32 E-value: 1.79e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 28 LGDM--PETFQYSTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIqaNGGLPAGYVLATKAD-RDFKtgdfS 104
Cdd:cd19096 5 FGTMrlPESDDDSIDEEKAIEMIRYAIDAGINYFDTAYGYGGGKSEEILGEAL--KEGPREKFYLATKLPpWSVK----S 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 105 GEQIKRSIEGSLERLGLDHLQYVYIHDPENTTFENVMGSGGPLEVLQKFQEQGVIDHIGISG-GPIDMLIRYVETGAFSA 183
Cdd:cd19096 79 AEDFRRILEESLKRLGVDYIDFYLLHGLNSPEWLEKARKGGLLEFLEKAKKEGLIRHIGFSFhDSPELLKEILDSYDFDF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 184 VETHnrYTLLNR---AAEPLLDVASRRDVAVINAAPYGSGILAkgpdayaryaysDAPPIVLERARmyakvcqEYNVPLA 260
Cdd:cd19096 159 VQLQ--YNYLDQenqAGRPGIEYAAKKGMGVIIMEPLKGGGLA------------NNPPEALAILC-------GAPLSPA 217
|
250 260 270
....*....|....*....|....*....|....
gi 950277055 261 AAALQFSLRDLRIASTVVGMSKPERVAQTIELAN 294
Cdd:cd19096 218 EWALRFLLSHPEVTTVLSGMSTPEQLDENIAAAD 251
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
18-309 |
8.32e-41 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 143.88 E-value: 8.32e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 18 ISPLCLGAAPLGdmPETFQYSTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQangGLPAGYVLATKadrd 97
Cdd:cd19085 1 VSRLGLGCWQFG--GGYWWGDQDDEESIATIHAALDAGINFFDTAEAYGDGHSEEVLGKALK---GRRDDVVIATK---- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 98 FKTGDFSGEQIKRSIEGSLERLGLDHLQYVYIHDP-ENTTFENVMgsggplEVLQKFQEQGVIDHIGISG-GPIDMliry 175
Cdd:cd19085 72 VSPDNLTPEDVRKSCERSLKRLGTDYIDLYQIHWPsSDVPLEETM------EALEKLKEEGKIRAIGVSNfGPAQL---- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 176 VETGAFSAVETH-NRYTLLNRAAE-PLLDVASRRDVAVINAAPYGSGILAKGPDAYARYAYSDAppivleRARMYA---- 249
Cdd:cd19085 142 EEALDAGRIDSNqLPYNLLWRAIEyEILPFCREHGIGVLAYSPLAQGLLTGKFSSAEDFPPGDA------RTRLFRhfep 215
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 950277055 250 --------------KVCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELANYPIAPELWSAFDAIG 309
Cdd:cd19085 216 gaeeetfealeklkEIADELGVTMAQLALAWVLQQPGVTSVIVGARNPEQLEENAAAVDLELSPSVLERLDEIS 289
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
9-290 |
1.41e-40 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 143.44 E-value: 1.41e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 9 RPLGSTGLLISPLCLGAAPLGDMpetFQYSTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQANGGLPAGY 88
Cdd:cd19153 3 ETLEIALGNVSPVGLGTAALGGV---YGDGLEQDEAVAIVAEAFAAGINHFDTSPYYGAESSEAVLGKALAALQVPRSSY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 89 VLATKADRDFKTG-DFSGEQIKRSIEGSLERLGLDHLQYVYIHDPENTTFENVMGSGGPleVLQKFQEQGVIDHIGISGG 167
Cdd:cd19153 80 TVATKVGRYRDSEfDYSAERVRASVATSLERLHTTYLDVVYLHDIEFVDYDTLVDEALP--ALRTLKDEGVIKRIGIAGY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 168 PIDML---IRYVETGAFSAVETHNRYTLLNRA---AEPLLdvASRRDVAVINAAPYGSGIL-AKGPDayaryAYSDAPPI 240
Cdd:cd19153 158 PLDTLtraTRRCSPGSLDAVLSYCHLTLQDARlesDAPGL--VRGAGPHVINASPLSMGLLtSQGPP-----PWHPASGE 230
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 950277055 241 VLERARMYAKVCQEYNVPLAAAALQFSLRD-LRIASTVVGMSKPERVAQTI 290
Cdd:cd19153 231 LRHYAAAADAVCASVEASLPDLALQYSLAAhAGVGTVLLGPSSLAQLRSML 281
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
16-291 |
4.90e-40 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 142.03 E-value: 4.90e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 16 LLISPLCLGAAPLGdmpetFQYSTSEEQALVT--LRTAFESPINFIDTAAAYGEgeSERRIGKAIQA-NGGLP-AGYVLA 91
Cdd:cd19164 11 AGLPPLIFGAATFS-----YQYTTDPESIPPVdiVRRALELGIRAFDTSPYYGP--SEIILGRALKAlRDEFPrDTYFII 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 92 TKADR-DFKTGDFSGEQIKRSIEGSLERLGLDHLQYVYIHDPENTTFENVMGSggpLEVLQKFQEQGVIDHIGISGGPID 170
Cdd:cd19164 84 TKVGRyGPDDFDYSPEWIRASVERSLRRLHTDYLDLVYLHDVEFVADEEVLEA---LKELFKLKDEGKIRNVGISGYPLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 171 MLIRYVET------GAFSAVETHNRYTLLNR---AAEPLLDVASRRDVaVINAAPYGSGIL-AKGPDayaryAYSDAPPI 240
Cdd:cd19164 161 VLLRLAELarttagRPLDAVLSYCHYTLQNTtllAYIPKFLAAAGVKV-VLNASPLSMGLLrSQGPP-----EWHPASPE 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 950277055 241 VLERARMYAKVCQEYNVPLAAAALQFSLR-DLRIASTVVGMSKPERVAQTIE 291
Cdd:cd19164 235 LRAAAAKAAEYCQAKGTDLADVALRYALReWGGEGPTVVGCSNVDELEEAVE 286
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
19-291 |
4.29e-38 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 134.95 E-value: 4.29e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 19 SPLCLGAAPLGDMpetfqysTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQANgGLPAGYVLATKA---- 94
Cdd:cd06660 1 SRLGLGTMTFGGD-------GDEEEAFALLDAALEAGGNFFDTADVYGDGRSERLLGRWLKGR-GNRDDVVIATKGghpp 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 95 DRDFKTGDFSGEQIKRSIEGSLERLGLDHLQYVYIH-DPENTTFENVMgsggplEVLQKFQEQGVIDHIGISGGPIDMLI 173
Cdd:cd06660 73 GGDPSRSRLSPEHIRRDLEESLRRLGTDYIDLYYLHrDDPSTPVEETL------EALNELVREGKIRYIGVSNWSAERLA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 174 RYVETGA------FSAVEthNRYTLLNRAA--EPLLDVASRRDVAVInaaPYGSgiLAKGPdayaryaysdappivlera 245
Cdd:cd06660 147 EALAYAKahglpgFAAVQ--PQYSLLDRSPmeEELLDWAEENGLPLL---AYSP--LARGP------------------- 200
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 950277055 246 rmyakvcqeynvplAAAALQFSLRDLRIASTVVGMSKPERVAQTIE 291
Cdd:cd06660 201 --------------AQLALAWLLSQPFVTVPIVGARSPEQLEENLA 232
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
9-308 |
1.97e-37 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 135.39 E-value: 1.97e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 9 RPLGSTGLLISPLCLGAaplgdMpeTFQYSTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIqangglpAG- 87
Cdd:cd19087 4 RTLGRTGLKVSRLCLGT-----M--NFGGRTDEETSFAIMDRALDAGINFFDTADVYGGGRSEEIIGRWI-------AGr 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 88 ---YVLATKAdrDFKTGD------FSGEQIKRSIEGSLERLGLDHLQYVYIHDP-ENTTFENVmgsggpLEVLQKFQEQG 157
Cdd:cd19087 70 rddIVLATKV--FGPMGDdpndrgLSRRHIRRAVEASLRRLQTDYIDLYQMHHFdRDTPLEET------LRALDDLVRQG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 158 VIDHIGISGGPIDMLIRYVETGA---FSAVETHN-RYTLLNRAAEP-LLDVASRRDVAVINAAPYGSGILA------KGP 226
Cdd:cd19087 142 KIRYIGVSNFAAWQIAKAQGIAArrgLLRFVSEQpMYNLLKRQAELeILPAARAYGLGVIPYSPLAGGLLTgkygkgKRP 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 227 DAY-----ARYAYSDAPPIVLERARMYAKVCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELANYPIAPEL 301
Cdd:cd19087 222 ESGrlverARYQARYGLEEYRDIAERFEALAAEAGLTPASLALAWVLSHPAVTSPIIGPRTLEQLEDSLAALEITLTPEL 301
|
....*..
gi 950277055 302 WSAFDAI 308
Cdd:cd19087 302 LAEIDEL 308
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
15-301 |
7.05e-36 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 131.17 E-value: 7.05e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 15 GLLISPLCLGAAPlgdmpeTFQYSTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQangGLP-AGYVLATK 93
Cdd:cd19074 1 GLKVSELSLGTWL------TFGGQVDDEDAKACVRKAYDLGINFFDTADVYAAGQAEEVLGKALK---GWPrESYVISTK 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 94 AdrDFKTGD------FSGEQIKRSIEGSLERLGLDHLQYVYIHDPENTTfenvmgsggPL-EVLQKFQE---QGVIDHIG 163
Cdd:cd19074 72 V--FWPTGPgpndrgLSRKHIFESIHASLKRLQLDYVDIYYCHRYDPET---------PLeETVRAMDDlirQGKILYWG 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 164 ISGGPIDMLIRYVET----GAFSAVETHNRYTLLNRAAEP-LLDVASRRDVAVINAAPYGSGILA----KG--PDAYARY 232
Cdd:cd19074 141 TSEWSAEQIAEAHDLarqfGLIPPVVEQPQYNMLWREIEEeVIPLCEKNGIGLVVWSPLAQGLLTgkyrDGipPPSRSRA 220
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 950277055 233 AYSDAPPI--------VLERARMYAKVCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELANYPIAPEL 301
Cdd:cd19074 221 TDEDNRDKkrrlltdeNLEKVKKLKPIADELGLTLAQLALAWCLRNPAVSSAIIGASRPEQLEENVKASGVKLSPEV 297
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
11-286 |
6.84e-35 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 128.86 E-value: 6.84e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 11 LGSTGLLISPLCLGAAPLGDmPETFQYSTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQANGGLPAgYVL 90
Cdd:cd19079 5 LGNSGLKVSRLCLGCMSFGD-PKWRPWVLDEEESRPIIKRALDLGINFFDTANVYSGGASEEILGRALKEFAPRDE-VVI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 91 ATK----ADRDFKTGDFSGEQIKRSIEGSLERLGLDHLQYVYIH--DPeNTTFENVMgsggplEVLQKFQEQGVIDHIGI 164
Cdd:cd19079 83 ATKvyfpMGDGPNGRGLSRKHIMAEVDASLKRLGTDYIDLYQIHrwDY-ETPIEETL------EALHDVVKSGKVRYIGA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 165 SGGPIDMLIRYVET----GAFSAVETHNRYTLLNRAAE-PLLDVASRRDVAVINAAPYGSGILAkGP------------- 226
Cdd:cd19079 156 SSMYAWQFAKALHLaeknGWTKFVSMQNHYNLLYREEErEMIPLCEEEGIGVIPWSPLARGRLA-RPwgdtterrrsttd 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 950277055 227 DAYARYAYS-DAPPIVLERARMYAKvcqEYNVPLAAAALQFSLRDLRIASTVVGMSKPERV 286
Cdd:cd19079 235 TAKLKYDYFtEADKEIVDRVEEVAK---ERGVSMAQVALAWLLSKPGVTAPIVGATKLEHL 292
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
8-300 |
1.14e-32 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 123.15 E-value: 1.14e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 8 KRPLGSTGLLISPLCLGAAPLGDMPetfQYSTSEEQALV-TLRTAFESPINFIDTAAAYGEGESERRIGKAIQangGLPA 86
Cdd:cd19149 1 YRKLGKSGIEASVIGLGTWAIGGGP---WWGGSDDNESIrTIHAALDLGINLIDTAPAYGFGHSEEIVGKAIK---GRRD 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 87 GYVLATKA----DRD----FKTGD-------FSGEQIKRSIEGSLERLGLDHLQYVYIHDPENTT-FENVMgsggplEVL 150
Cdd:cd19149 75 KVVLATKCglrwDREggsfFFVRDgvtvyknLSPESIREEVEQSLKRLGTDYIDLYQTHWQDVETpIEETM------EAL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 151 QKFQEQGVIDHIGISGGPIDMLIRYVETGAFSAVEThnRYTLLNRAAEP-LLDVASRRDVAVINAAPYGSGILAKGPDAY 229
Cdd:cd19149 149 EELKRQGKIRAIGASNVSVEQIKEYVKAGQLDIIQE--KYSMLDRGIEKeLLPYCKKNNIAFQAYSPLEQGLLTGKITPD 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 230 ARYAYSDA--------PPIVLERARMYAK---VCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELANYPIA 298
Cdd:cd19149 227 REFDAGDArsgipwfsPENREKVLALLEKwkpLCEKYGCTLAQLVIAWTLAQPGITSALCGARKPEQAEENAKAGDIRLS 306
|
..
gi 950277055 299 PE 300
Cdd:cd19149 307 AE 308
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
18-308 |
4.69e-32 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 121.24 E-value: 4.69e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 18 ISPLCLGAAPLGDMPETFQYST-SEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQANGGLPAgyvLATK--- 93
Cdd:cd19102 1 LTTIGLGTWAIGGGGWGGGWGPqDDRDSIAAIRAALDLGINWIDTAAVYGLGHSEEVVGRALKGLRDRPI---VATKcgl 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 94 --ADRDFKTGDFSGEQIKRSIEGSLERLGLDHLQYVYIHDPENTTfenvmgsggPLE----VLQKFQEQGVIDHIGISGG 167
Cdd:cd19102 78 lwDEEGRIRRSLKPASIRAECEASLRRLGVDVIDLYQIHWPDPDE---------PIEeawgALAELKEEGKVRAIGVSNF 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 168 PIDMLIRYVETGAFSAVEthNRYTLLNRAAE-PLLDVASRRDVAVINAAPYGSGIL--AKGPDAYARYAYSDAPPivleR 244
Cdd:cd19102 149 SVDQMKRCQAIHPIASLQ--PPYSLLRRGIEaEILPFCAEHGIGVIVYSPMQSGLLtgKMTPERVASLPADDWRR----R 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 950277055 245 ARMYAK---------------VCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELANYPIAPELWSAFDAI 308
Cdd:cd19102 223 SPFFQEpnlarnlalvdalrpIAERHGRTVAQLAIAWVLRRPEVTSAIVGARRPDQIDETVGAADLRLTPEELAEIEAL 301
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
19-297 |
6.79e-32 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 119.55 E-value: 6.79e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 19 SPLCLGAAPLGdMPetfqYS-------TSEEQALVTLRTAFESPINFIDTAAAYgeGESERRIGKAIQANGGLpagyVLA 91
Cdd:cd19097 1 SKLALGTAQFG-LD----YGianksgkPSEKEAKKILEYALKAGINTLDTAPAY--GDSEKVLGKFLKRLDKF----KII 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 92 TKADRDFKTGDFSGEQIKRSIEGSLERLGLDHLQYVYIHDPenttfENVMGSGGPL-EVLQKFQEQGVIDHIGISGGPID 170
Cdd:cd19097 70 TKLPPLKEDKKEDEAAIEASVEASLKRLKVDSLDGLLLHNP-----DDLLKHGGKLvEALLELKKEGLIRKIGVSVYSPE 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 171 MLIRYVETGAFSAVEThnRYTLLNR--AAEPLLDVASRRDVAVinaapygsgilakgpdaYARYAY--------SDAPPI 240
Cdd:cd19097 145 ELEKALESFKIDIIQL--PFNILDQrfLKSGLLAKLKKKGIEI-----------------HARSVFlqglllmePDKLPA 205
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 950277055 241 VLERA----RMYAKVCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELANYPI 297
Cdd:cd19097 206 KFAPAkpllKKLHELAKKLGLSPLELALGFVLSLPEIDKIVVGVDSLEQLKEIIAAFKKPP 266
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
18-308 |
2.68e-31 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 119.59 E-value: 2.68e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 18 ISPLCLGAaplgdMpeTFQYSTSEEQALVTLRTAFESPINFIDTAAAY-------GEGESERRIGKAIQANGG---Lpag 87
Cdd:cd19094 1 VSEICLGT-----M--TWGEQNTEAEAHEQLDYAFDEGVNFIDTAEMYpvppspeTQGRTEEIIGSWLKKKGNrdkV--- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 88 yVLATK-----ADRDFKTGDFSG---EQIKRSIEGSLERLGLDHLQYVYIHDPENTTfeNVMGSGGP------------- 146
Cdd:cd19094 71 -VLATKvagpgEGITWPRGGGTRldrENIREAVEGSLKRLGTDYIDLYQLHWPDRYT--PLFGGGYYtepseeedsvsfe 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 147 --LEVLQKFQEQGVIDHIGISG----GpidmLIRYVETGafsavETH---------NRYTLLNRAAEPLL-DVASRRDVA 210
Cdd:cd19094 148 eqLEALGELVKAGKIRHIGLSNetpwG----VMKFLELA-----EQLglprivsiqNPYSLLNRNFEEGLaEACHRENVG 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 211 VINAAPYGSGIL-------AKGP-----DAYARYAYSDAPPIVLERARMYAKVCQEYNVPLAAAALQFSLRDLRIASTVV 278
Cdd:cd19094 219 LLAYSPLAGGVLtgkyldgAARPeggrlNLFPGYMARYRSPQALEAVAEYVKLARKHGLSPAQLALAWVRSRPFVTSTII 298
|
330 340 350
....*....|....*....|....*....|
gi 950277055 279 GMSKPERVAQTIELANYPIAPELWSAFDAI 308
Cdd:cd19094 299 GATTLEQLKENIDAFDVPLSDELLAEIDAV 328
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
9-308 |
4.92e-30 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 116.17 E-value: 4.92e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 9 RPLGSTGLLISPLCLGAAPLGDMPETFQ--YSTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIqanGGLPA 86
Cdd:cd19091 4 RTLGRSGLKVSELALGTMTFGGGGGFFGawGGVDQEEADRLVDIALDAGINFFDTADVYSEGESEEILGKAL---KGRRD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 87 GYVLATKAdrDFKTGD------FSGEQIKRSIEGSLERLGLDHLQYVYIHDPENTT-FENVmgsggpLEVLQKFQEQGVI 159
Cdd:cd19091 81 DVLIATKV--RGRMGEgpndvgLSRHHIIRAVEASLKRLGTDYIDLYQLHGFDALTpLEET------LRALDDLVRQGKV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 160 DHIGIS---GGPIDMLIRYVETGAFSAVETHN-RYTLLNRAAE-PLLDVASRRDVAVINAAPYGSGIL------AKGPDA 228
Cdd:cd19091 153 RYIGVSnfsAWQIMKALGISERRGLARFVALQaYYSLLGRDLEhELMPLALDQGVGLLVWSPLAGGLLsgkyrrGQPAPE 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 229 YARYAYSDAPPIVLERARMYA------KVCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELANYPIAPELW 302
Cdd:cd19091 233 GSRLRRTGFDFPPVDRERGYDvvdalrEIAKETGATPAQVALAWLLSRPTVSSVIIGARNEEQLEDNLGAAGLSLTPEEI 312
|
....*.
gi 950277055 303 SAFDAI 308
Cdd:cd19091 313 ARLDKV 318
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
9-306 |
4.49e-29 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 113.08 E-value: 4.49e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 9 RPLGSTGLLISPLCLGAAPLGdmpETFQYSTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQANGGlpaGY 88
Cdd:cd19080 1 RLLGRSGLRVSPLALGTMTFG---TEWGWGADREEARAMFDAYVEAGGNFIDTANNYTNGTSERLLGEFIAGNRD---RI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 89 VLATKADRDFKTGD--FSGEQIK---RSIEGSLERLGLDHLQYVYIHDPENTT-FENVMGSggpLEVLQKfqeQGVIDHI 162
Cdd:cd19080 75 VLATKYTMNRRPGDpnAGGNHRKnlrRSVEASLRRLQTDYIDLLYVHAWDFTTpVEEVMRA---LDDLVR---AGKVLYV 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 163 GISGGP------IDMLIRYVETGAFSAVETHnrYTLLNRAAE-PLLDVASRRDVAVINAAPYGSGIL----AKGPDAYAR 231
Cdd:cd19080 149 GISDTPawvvarANTLAELRGWSPFVALQIE--YSLLERTPErELLPMARALGLGVTPWSPLGGGLLtgkyQRGEEGRAG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 232 YAYSDAPPIVLERARMYA------KVCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELANYPIAPELWSAF 305
Cdd:cd19080 227 EAKGVTVGFGKLTERNWAivdvvaAVAEELGRSAAQVALAWVRQKPGVVIPIIGARTLEQLKDNLGALDLTLSPEQLARL 306
|
.
gi 950277055 306 D 306
Cdd:cd19080 307 D 307
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
18-224 |
1.06e-28 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 111.16 E-value: 1.06e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 18 ISPLCLGAAPLGdMPETFQYSTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIqanGGLPAGYVLATKA--- 94
Cdd:cd19088 1 VSRLGYGAMRLT-GPGIWGPPADREEAIAVLRRALELGVNFIDTADSYGPDVNERLIAEAL---HPYPDDVVIATKGglv 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 95 ---DRDFKTgDFSGEQIKRSIEGSLERLGLDHLQYVYIH--DPEnTTFENvmgsggPLEVLQKFQEQGVIDHIGISGGPI 169
Cdd:cd19088 77 rtgPGWWGP-DGSPEYLRQAVEASLRRLGLDRIDLYQLHriDPK-VPFEE------QLGALAELQDEGLIRHIGLSNVTV 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 950277055 170 DMLIRYVETGAFSAVEthNRYTLLNRAAEPLLDVASRRDVAVINAAPYGSGILAK 224
Cdd:cd19088 149 AQIEEARAIVRIVSVQ--NRYNLANRDDEGVLDYCEAAGIAFIPWFPLGGGDLAQ 201
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
10-306 |
1.90e-28 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 111.54 E-value: 1.90e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 10 PLGSTGLLISPLCLGAAplgdmpeTFQYSTSEEQALVTLRTAFESPINFIDTAAAYG-------EGESERRIGKAIQANG 82
Cdd:cd19081 1 PLGRTGLSVSPLCLGTM-------VFGWTADEETSFALLDAFVDAGGNFIDTADVYSawvpgnaGGESETIIGRWLKSRG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 83 GLPAgYVLATK--ADRDFKTGDFSGEQIKRSIEGSLERLGLDHLQYVYIH--DPENTTFEnvmgsggPLEVLQKFQEQGV 158
Cdd:cd19081 74 KRDR-VVIATKvgFPMGPNGPGLSRKHIRRAVEASLRRLQTDYIDLYQAHwdDPATPLEE-------TLGALNDLIRQGK 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 159 IDHIGISGGPIDMLIRYVETG------AFSAVETHnrYTLLNRAA--EPLLDVASRRDVAVINAAPYGSGILAkgpdayA 230
Cdd:cd19081 146 VRYIGASNYSAWRLQEALELSrqhglpRYVSLQPE--YNLVDRESfeGELLPLCREEGIGVIPYSPLAGGFLT------G 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 231 RYAYSDAPPIVLERARMYAK---------------VCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELANY 295
Cdd:cd19081 218 KYRSEADLPGSTRRGEAAKRylnerglrildaldeVAAEHGATPAQVALAWLLARPGVTAPIAGARTVEQLEDLLAAAGL 297
|
330
....*....|.
gi 950277055 296 PIAPELWSAFD 306
Cdd:cd19081 298 RLTDEEVARLD 308
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
8-308 |
7.24e-28 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 109.82 E-value: 7.24e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 8 KRPLGSTGLLISPLCLGAAPLGDmpETFQYSTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQanGGLPAG 87
Cdd:cd19083 1 KVKLGKSDIDVNPIGLGTNAVGG--HNLYPNLDEEEGKDLVREALDNGVNLLDTAFIYGLGRSEELVGEVLK--EYNRNE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 88 YVLATKADRDFKTGDF----SGEQIKRSIEGSLERLGLDHLQYVYIHDP-ENTTFENVMGSggplevLQKFQEQGVIDHI 162
Cdd:cd19083 77 VVIATKGAHKFGGDGSvlnnSPEFLRSAVEKSLKRLNTDYIDLYYIHFPdGETPKAEAVGA------LQELKDEGKIRAI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 163 GISGGPIDMLIRYVETGAFSAVEthNRYTLLNRAAEP-LLDVASRRDVAVINAAPYGSGILA-------KGPDAYAR--Y 232
Cdd:cd19083 151 GVSNFSLEQLKEANKDGYVDVLQ--GEYNLLQREAEEdILPYCVENNISFIPYFPLASGLLAgkytkdtKFPDNDLRndK 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 950277055 233 AYSDAPPIV--LERARMYAKVCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELANYPIAPELWSAFDAI 308
Cdd:cd19083 229 PLFKGERFSenLDKVDKLKSIADEKGVTVAHLALAWYLTRPAIDVVIPGAKRAEQVIDNLKALDVTLTEEEIAFIDAL 306
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
13-302 |
1.53e-27 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 108.80 E-value: 1.53e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 13 STGLLISPLCLGAAPLGDMPETfqystsEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQANGGLPAGYVLAT 92
Cdd:cd19092 1 PEGLEVSRLVLGCMRLADWGES------AEELLSLIEAALELGITTFDHADIYGGGKCEELFGEALALNPGLREKIEIQT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 93 KAD-------RDFKTG--DFSGEQIKRSIEGSLERLGLDHLQYVYIH------DPENTTfenvmgsggplEVLQKFQEQG 157
Cdd:cd19092 75 KCGirlgddpRPGRIKhyDTSKEHILASVEGSLKRLGTDYLDLLLLHrpdplmDPEEVA-----------EAFDELVKSG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 158 VIDHIGIS---GGPIDMLIRYVEtgaFSAVETHNRYTLLNraAEPL----LDVASRRDVAVINAAPYGSGILAKGPDAYA 230
Cdd:cd19092 144 KVRYFGVSnftPSQIELLQSYLD---QPLVTNQIELSLLH--TEAIddgtLDYCQLLDITPMAWSPLGGGRLFGGFDERF 218
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 950277055 231 ryaysdappivlERARMY-AKVCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELANYPIAPELW 302
Cdd:cd19092 219 ------------QRLRAAlEELAEEYGVTIEAIALAWLLRHPARIQPILGTTNPERIRSAVKALDIELTREEW 279
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
16-291 |
2.42e-27 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 108.56 E-value: 2.42e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 16 LLISPLCLGAAPLGDMPETFqystseEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQ---ANGGLP------- 85
Cdd:cd19099 1 LTLSSLGLGTYRGDSDDETD------EEYREALKAALDSGINVIDTAINYRGGRSERLIGKALReliEKGGIKrdevviv 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 86 --AGYV---------------------LATKADRDFKTGDFSGEQIKRSIEGSLERLGLDHLQYVYIHDPE-------NT 135
Cdd:cd19099 75 tkAGYIpgdgdeplrplkyleeklgrgLIDVADSAGLRHCISPAYLEDQIERSLKRLGLDTIDLYLLHNPEeqllelgEE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 136 TFENVMGSGgpLEVLQKFQEQGVIDHIGIS---------GGPIDMLIRYVETGA---------FSAVET---------HN 188
Cdd:cd19099 155 EFYDRLEEA--FEALEEAVAEGKIRYYGIStwdgfrappALPGHLSLEKLVAAAeevggdnhhFKVIQLplnllepeaLT 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 189 RYTLLNRAAEPLLDVASRRDVAVINAAPYGSGILAKGpdayaryaysdaPPIVLERARMYAKvcqeynvPLAAAALQFSL 268
Cdd:cd19099 233 EKNTVKGEALSLLEAAKELGLGVIASRPLNQGQLLGE------------LRLADLLALPGGA-------TLAQRALQFAR 293
|
330 340
....*....|....*....|...
gi 950277055 269 RDLRIASTVVGMSKPERVAQTIE 291
Cdd:cd19099 294 STPGVDSALVGMRRPEHVDENLA 316
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
18-264 |
1.39e-25 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 103.46 E-value: 1.39e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 18 ISPLCLGAAPLGDMPETFQYSTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQANgGLPAGYVLATKADRD 97
Cdd:cd19093 2 VSPLGLGTWQWGDRLWWGYGEYGDEDLQAAFDAALEAGVNLFDTAEVYGTGRSERLLGRFLKEL-GDRDEVVIATKFAPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 98 FKTgdFSGEQIKRSIEGSLERLGLDHLQYVYIHDPenttFENVMGSGGPLEVLQKFQEQGVIDHIGISGGPIDMLIRyve 177
Cdd:cd19093 81 PWR--LTRRSVVKALKASLERLGLDSIDLYQLHWP----GPWYSQIEALMDGLADAVEEGLVRAVGVSNYSADQLRR--- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 178 tgAFSAVETH--------NRYTLLNRAAEP--LLDVASRRDVAVINAAPYGSGIL---------AKGPDA--YARYAYSD 236
Cdd:cd19093 152 --AHKALKERgvplasnqVEYSLLYRDPEQngLLPACDELGITLIAYSPLAQGLLtgkyspenpPPGGRRrlFGRKNLEK 229
|
250 260 270
....*....|....*....|....*....|
gi 950277055 237 APPI--VLERarmyakVCQEYNVPLAAAAL 264
Cdd:cd19093 230 VQPLldALEE------IAEKYGKTPAQVAL 253
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
9-296 |
4.47e-24 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 99.64 E-value: 4.47e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 9 RPLGSTGLLISPLCLGaaplgdMPETFQYSTSEEQALVTLRTAFESPINFIDTAAAYG--EGESERRIGKAIQANgglPA 86
Cdd:cd19089 2 RRCGRSGLHLPAISLG------LWHNFGDYTSPEEARELLRTAFDLGITHFDLANNYGppPGSAEENFGRILKRD---LR 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 87 GY----VLATKADrdFKT-----GDF-SGEQIKRSIEGSLERLGLDHLQYVYIHDPENTTfenvmgsggPLEV----LQK 152
Cdd:cd19089 73 PYrdelVISTKAG--YGMwpgpyGDGgSRKYLLASLDQSLKRMGLDYVDIFYHHRYDPDT---------PLEEtmtaLAD 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 153 FQEQGVIDHIGISGGPIDMLIRYVET----GAfSAVETHNRYTLLNRAAEP-LLDVASRRDVAVINAAPYGSGILA---- 223
Cdd:cd19089 142 AVRSGKALYVGISNYPGAKARRAIALlrelGV-PLIIHQPRYSLLDRWAEDgLLEVLEEAGIGFIAFSPLAQGLLTdkyl 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 224 KGPDAYARYAYSDA-------PPIVLERARMYAKVCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELANYP 296
Cdd:cd19089 221 NGIPPDSRRAAESKflteealTPEKLEQLRKLNKIAAKRGQSLAQLALSWVLRDPRVTSVLIGASSPSQLEDNVAALKNL 300
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
8-223 |
7.39e-24 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 98.83 E-value: 7.39e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 8 KRPLGSTGLLISPLCLGAaplgdMPETFQYST-SEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQANGGlpa 86
Cdd:cd19076 2 TRKLGTQGLEVSALGLGC-----MGMSAFYGPaDEEESIATLHRALELGVTFLDTADMYGPGTNEELLGKALKDRRD--- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 87 GYVLATK--ADRDFKTG----DFSGEQIKRSIEGSLERLGLDHLQYVYIH--DPeNTTFENVMGsggpleVLQKFQEQGV 158
Cdd:cd19076 74 EVVIATKfgIVRDPGSGfrgvDGRPEYVRAACEASLKRLGTDVIDLYYQHrvDP-NVPIEETVG------AMAELVEEGK 146
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 950277055 159 IDHIGISGGPIDMLIRYVETGAFSAVEThnRYTLLNRAAEP-LLDVASRRDVAVINAAPYGSGILA 223
Cdd:cd19076 147 VRYIGLSEASADTIRRAHAVHPITAVQS--EYSLWTRDIEDeVLPTCRELGIGFVAYSPLGRGFLT 210
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
41-300 |
2.07e-23 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 96.91 E-value: 2.07e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 41 EEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIqangglpAGY-----VLATKADRDFktgdFSGEQIKRSIEGS 115
Cdd:cd19072 25 DKKAIEALRYAIELGINLIDTAEMYGGGHAEELVGKAI-------KGFdredlFITTKVSPDH----LKYDDVIKAAKES 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 116 LERLGLDHLQYVYIHDPenttfenvmGSGGPLE----VLQKFQEQGVIDHIGISGGPIDMLIRYVET---GAFSAVETHn 188
Cdd:cd19072 94 LKRLGTDYIDLYLIHWP---------NPSIPIEetlrAMEELVEEGKIRYIGVSNFSLEELEEAQSYlkkGPIVANQVE- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 189 rYTLLNRAAEP-LLDVASRRDVAVINAAPYGSGILakgpdayaryaysdappIVLERARMYAKVCQEYNVPLAAAALQFS 267
Cdd:cd19072 164 -YNLFDREEESgLLPYCQKNGIAIIAYSPLEKGKL-----------------SNAKGSPLLDEIAKKYGKTPAQIALNWL 225
|
250 260 270
....*....|....*....|....*....|...
gi 950277055 268 LRDLRIAsTVVGMSKPERVAQTIELANYPIAPE 300
Cdd:cd19072 226 ISKPNVI-AIPKASNIEHLEENAGALGWELSEE 257
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
23-308 |
5.33e-23 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 96.47 E-value: 5.33e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 23 LGAAPLGDMPETFQYSTSEEqalvTLRTAFESPINFIDTAAAYGEGESERRIGKAIQANgglpAGYVLATKAdRDFKTGD 102
Cdd:cd19075 5 LGTMTFGSQGRFTTAEAAAE----LLDAFLERGHTEIDTARVYPDGTSEELLGELGLGE----RGFKIDTKA-NPGVGGG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 103 FSGEQIKRSIEGSLERLGLDHLQYVYIHDPENTTfenvmgsggPLEV-LQKFQE---QGVIDHIGISGGPIDMLIRYVET 178
Cdd:cd19075 76 LSPENVRKQLETSLKRLKVDKVDVFYLHAPDRST---------PLEEtLAAIDElykEGKFKEFGLSNYSAWEVAEIVEI 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 179 gafsaVETHN---------RYTLLNRAAEP-LLDVASRRDVAVINAAPYGSGILAKgpdayaRYAYSDAP---------- 238
Cdd:cd19075 147 -----CKENGwvlptvyqgMYNAITRQVETeLFPCLRKLGIRFYAYSPLAGGFLTG------KYKYSEDKagggrfdpnn 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 239 ------------PIVLERARMYAKVCQEYNVPLAAAA---------LQFSLRDlRIastVVGMSKPERVAQTIE-LANYP 296
Cdd:cd19075 216 algklyrdrywkPSYFEALEKVEEAAEKEGISLAEAAlrwlyhhsaLDGEKGD-GV---ILGASSLEQLEENLAaLEKGP 291
|
330
....*....|..
gi 950277055 297 IAPELWSAFDAI 308
Cdd:cd19075 292 LPEEVVKAIDEA 303
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
19-294 |
4.06e-20 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 88.38 E-value: 4.06e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 19 SPLCLGAAPLGDMpetfqysTSEEQALVTLRTAFESPINFIDTAAAYG----EGESERRIGKAIQANgGLPAGYVLATK- 93
Cdd:cd19082 1 SRIVLGTADFGTR-------IDEEEAFALLDAFVELGGNFIDTARVYGdwveRGASERVIGEWLKSR-GNRDKVVIATKg 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 94 ---ADRDFKTGDFSGEQIKRSIEGSLERLGLDHLQYVYIH-DPENTTFENVMgsggplEVLQKFQEQGVIDHIGISGGPI 169
Cdd:cd19082 73 ghpDLEDMSRSRLSPEDIRADLEESLERLGTDYIDLYFLHrDDPSVPVGEIV------DTLNELVRAGKIRAFGASNWST 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 170 DMLIRYVETGA------FSAVETHnrYTLLNRAAEPLLDVAS------------RRDVAVINAAPYGSGILAKG------ 225
Cdd:cd19082 147 ERIAEANAYAKahglpgFAASSPQ--WSLARPNEPPWPGPTLvamdeemrawheENQLPVFAYSSQARGFFSKRaaggae 224
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 226 -PDAYARYAYSDAPPIVLERARmyaKVCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELAN 294
Cdd:cd19082 225 dDSELRRVYYSEENFERLERAK---ELAEEKGVSPTQIALAYVLNQPFPTVPIIGPRTPEQLRDSLAAAD 291
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
39-222 |
6.56e-20 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 88.13 E-value: 6.56e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 39 TSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIqANGGLPAGYVLATKA-----DRDFKTGDFSGEQIKRSIE 113
Cdd:cd19148 22 TDEKEAIETIHKALDLGINLIDTAPVYGFGLSEEIVGKAL-KEYGKRDRVVIATKVglewdEGGEVVRNSSPARIRKEVE 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 114 GSLERLGLDHLQYVYIHDPENTT-FENVMgsggplEVLQKFQEQGVIDHIGISGGPIDMLIRYVETGAFSAVEThnRYTL 192
Cdd:cd19148 101 DSLRRLQTDYIDLYQVHWPDPLVpIEETA------EALKELLDEGKIRAIGVSNFSPEQMETFRKVAPLHTVQP--PYNL 172
|
170 180 190
....*....|....*....|....*....|.
gi 950277055 193 LNRAAE-PLLDVASRRDVAVINAAPYGSGIL 222
Cdd:cd19148 173 FEREIEkDVLPYARKHNIVTLAYGALCRGLL 203
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
15-236 |
1.49e-19 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 86.90 E-value: 1.49e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 15 GLLISPLCLGAapLGdMPETFQYSTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIqangglpAGY----VL 90
Cdd:cd19078 1 GLEVSAIGLGC--MG-MSHGYGPPPDKEEMIELIRKAVELGITFFDTAEVYGPYTNEELVGEAL-------KPFrdqvVI 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 91 ATKADRDF-------KTGDFSGEQIKRSIEGSLERLGLDHLQYVYIH--DPeNTTFENVMGsggpleVLQKFQEQGVIDH 161
Cdd:cd19078 71 ATKFGFKIdggkpgpLGLDSRPEHIRKAVEGSLKRLQTDYIDLYYQHrvDP-NVPIEEVAG------TMKELIKEGKIRH 143
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 950277055 162 IGISGGPIDMLIRYVETGAFSAVEthNRYTLLNRAAE-PLLDVASRRDVAVINAAPYGSGILAKGPDAYARYAYSD 236
Cdd:cd19078 144 WGLSEAGVETIRRAHAVCPVTAVQ--SEYSMMWREPEkEVLPTLEELGIGFVPFSPLGKGFLTGKIDENTKFDEGD 217
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
6-222 |
1.37e-17 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 81.72 E-value: 1.37e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 6 LSKRPLGSTGLLISPLCLGAAPLGDMPETfqySTSEEQALVTLRTAFESPINFIDTAAAYGEgeSERRIGKAIQANGGLP 85
Cdd:cd19144 1 IPTRTLGRNGPSVPALGFGAMGLSAFYGP---PKPDEERFAVLDAAFELGCTFWDTADIYGD--SEELIGRWFKQNPGKR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 86 AGYVLATK--ADRDFKTGDF----SGEQIKRSIEGSLERLGLDHLQYVYIH--DPEnTTFENVMGSggplevLQKFQEQG 157
Cdd:cd19144 76 EKIFLATKfgIEKNVETGEYsvdgSPEYVKKACETSLKRLGVDYIDLYYQHrvDGK-TPIEKTVAA------MAELVQEG 148
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 950277055 158 VIDHIGISGGPIDMLIRYVETGAFSAVET-HNRYTL-LNRAAEPLLDVASRRDVAVINAAPYGSGIL 222
Cdd:cd19144 149 KIKHIGLSECSAETLRRAHAVHPIAAVQIeYSPFSLdIERPEIGVLDTCRELGVAIVAYSPLGRGFL 215
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
40-300 |
1.89e-17 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 80.01 E-value: 1.89e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 40 SEEQALVTLRTAFESPINFIDTAAAYgegESERRIGKAIQANGGLPAGYVLATKADRDFktgdFSGEQIKRSIEGSLERL 119
Cdd:cd19073 12 RGDDCANAVKEALELGYRHIDTAEIY---NNEAEVGEAIAESGVPREDLFITTKVWRDH----LRPEDLKKSVDRSLEKL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 120 GLDHLQYVYIHDPENTT-FENVmgsggpLEVLQKFQEQGVIDHIGISGGPIDML---IRYVETG-AFSAVETHnryTLLN 194
Cdd:cd19073 85 GTDYVDLLLIHWPNPTVpLEET------LGALKELKEAGKVKSIGVSNFTIELLeeaLDISPLPiAVNQVEFH---PFLY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 195 RAAepLLDVASRRDVAVINAAPygsgiLAKGPDAyaryaysDAPPIVlerarmyaKVCQEYNVPLAaaalQFSLRDLRIA 274
Cdd:cd19073 156 QAE--LLEYCRENDIVITAYSP-----LARGEVL-------RDPVIQ--------EIAEKYDKTPA----QVALRWLVQK 209
|
250 260
....*....|....*....|....*...
gi 950277055 275 STVV--GMSKPERVAQTIELANYPIAPE 300
Cdd:cd19073 210 GIVVipKASSEDHLKENLAIFDWELTSE 237
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
9-308 |
5.25e-17 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 79.95 E-value: 5.25e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 9 RPLGSTGLLISPLCLGAAPlgdmpeTFQYSTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQaNGGLP-AG 87
Cdd:cd19143 4 RRLGRSGLKVSALSFGSWV------TFGNQVDVDEAKECMKAAYDAGVNFFDNAEVYANGQSEEIMGQAIK-ELGWPrSD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 88 YVLATK------ADRDFKTGdFSGEQIKRSIEGSLERLGLDHLQYVYIHDPENTTfenvmgsggPL-EVLQKFQEqgVID 160
Cdd:cd19143 77 YVVSTKifwgggGPPPNDRG-LSRKHIVEGTKASLKRLQLDYVDLVFCHRPDPAT---------PIeETVRAMND--LID 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 161 HiGisggpidmLIRYVETGAFSAVETHN------RYTLLNRAAE-PLLDVASRRDVAVINA-------------APYGSG 220
Cdd:cd19143 145 Q-G--------KAFYWGTSEWSAQQIEEaheiadRLGLIPPVMEqPQYNLFHRERVEVEYAplyekyglgtttwSPLASG 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 221 IL----AKGPDAYARYAYSDAP----------PIVLERARMYAKVCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERV 286
Cdd:cd19143 216 LLtgkyNNGIPEGSRLALPGYEwlkdrkeelgQEKIEKVRKLKPIAEELGCSLAQLAIAWCLKNPNVSTVITGATKVEQL 295
|
330 340
....*....|....*....|....
gi 950277055 287 AQTIE-LANYP-IAPELWSAFDAI 308
Cdd:cd19143 296 EENLKaLEVLPkLTPEVMEKIEAI 319
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
34-226 |
5.57e-17 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 78.94 E-value: 5.57e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 34 TFQYSTSEEQALVtlRTAFESPINFIDTAAAYGegeSERRIGKAIqANGGLPAGYV-LATKADRDfktgDFSGEQIKRSI 112
Cdd:COG0656 12 TWQLPGEEAAAAV--RTALEAGYRHIDTAAMYG---NEEGVGEAI-AASGVPREELfVTTKVWND----NHGYDDTLAAF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 113 EGSLERLGLDHLQYVYIHDPENTTFENVMgsggplEVLQKFQEQGVIDHIGISGGPIDMLIR-YVETGAFSAV---ETHn 188
Cdd:COG0656 82 EESLERLGLDYLDLYLIHWPGPGPYVETW------RALEELYEEGLIRAIGVSNFDPEHLEElLAETGVKPAVnqvELH- 154
|
170 180 190
....*....|....*....|....*....|....*...
gi 950277055 189 rytLLNRAAEpLLDVASRRDVAVINAAPYGSGILAKGP 226
Cdd:COG0656 155 ---PYLQQRE-LLAFCREHGIVVEAYSPLGRGKLLDDP 188
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
12-296 |
1.16e-16 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 78.98 E-value: 1.16e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 12 GSTGLLISPLCLGaaplgdMPETFQYSTSEEQALVTLRTAFESPINFIDTAAAYGE--GESERRIGKAIQANgglPAGY- 88
Cdd:cd19151 6 GRSGLKLPAISLG------LWHNFGDVDRYENSRAMLRRAFDLGITHFDLANNYGPppGSAEENFGRILKED---LKPYr 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 89 ---VLATKADR---DFKTGDF-SGEQIKRSIEGSLERLGLDHLQYVYIHDPE-NTTFENVMGSggplevLQKFQEQGVID 160
Cdd:cd19151 77 delIISTKAGYtmwPGPYGDWgSKKYLIASLDQSLKRMGLDYVDIFYHHRPDpETPLEETMGA------LDQIVRQGKAL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 161 HIGISGGPIDmliryvETG-AFSAVET-------HN-RYTLLNRAAEP-LLDVASRRDVAVINAAPYGSGILA----KGP 226
Cdd:cd19151 151 YVGISNYPPE------EAReAAAILKDlgtpcliHQpKYSMFNRWVEEgLLDVLEEEGIGCIAFSPLAQGLLTdrylNGI 224
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 950277055 227 DAYARYAYSDAP-------PIVLERARMYAKVCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELANYP 296
Cdd:cd19151 225 PEDSRAAKGSSFlkpeqitEEKLAKVRRLNEIAQARGQKLAQMALAWVLRNKRVTSVLIGASKPSQIEDAVGALDNR 301
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
8-226 |
1.42e-16 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 78.63 E-value: 1.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 8 KRPLGSTGLLISPLCLGAaplgdMPETFQYST--SEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQangGLP 85
Cdd:cd19145 2 RVKLGSQGLEVSAQGLGC-----MGLSGDYGApkPEEEGIALIHHAFNSGVTFLDTSDIYGPNTNEVLLGKALK---DGP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 86 AGYV-LATKAdrDFKTGDFSGEQIK------RS-IEGSLERLGLDHLQYVYIHDPENTT-FENVMGSggplevLQKFQEQ 156
Cdd:cd19145 74 REKVqLATKF--GIHEIGGSGVEVRgdpayvRAaCEASLKRLDVDYIDLYYQHRIDTTVpIEITMGE------LKKLVEE 145
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 950277055 157 GVIDHIGISGGPIDMLIRYVETGAFSAVEThnRYTLLNR-AAEPLLDVASRRDVAVINAAPYGSGILAKGP 226
Cdd:cd19145 146 GKIKYIGLSEASADTIRRAHAVHPITAVQL--EWSLWTRdIEEEIIPTCRELGIGIVPYSPLGRGFFAGKA 214
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
15-224 |
1.55e-15 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 74.91 E-value: 1.55e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 15 GLLISPLCLGAAPLGDMpETFQYStSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQangGLPAGYVLATKa 94
Cdd:cd19137 1 GEKIPALGLGTWGIGGF-LTPDYS-RDEEMVELLKTAIELGYTHIDTAEMYGGGHTEELVGKAIK---DFPREDLFIVT- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 95 dRDFKTgDFSGEQIKRSIEGSLERLGLDHLQYVYIHDPE-NTTFENVMGSggplevLQKFQEQGVIDHIGISGGPIDMLI 173
Cdd:cd19137 75 -KVWPT-NLRYDDLLRSLQNSLRRLDTDYIDLYLIHWPNpNIPLEETLSA------MAEGVRQGLIRYIGVSNFNRRLLE 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 950277055 174 RYVETGAFSAVETHNRYTLLNRAAEP--LLDVASRRDVAVINAAPYGSGILAK 224
Cdd:cd19137 147 EAISKSQTPIVCNQVKYNLEDRDPERdgLLEYCQKNGITVVAYSPLRRGLEKT 199
|
|
| AKR_AKR9A3_9B1-4 |
cd19147 |
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ... |
11-198 |
1.79e-15 |
|
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381373 [Multi-domain] Cd Length: 319 Bit Score: 75.63 E-value: 1.79e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 11 LGST-GLLISPLCLGAAPLGDMPETFQYSTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQANgGLPAGYV 89
Cdd:cd19147 2 LSKTaGIRVSPLILGAMSIGDAWSGFMGSMDKEQAFELLDAFYEAGGNFIDTANNYQDEQSETWIGEWMKSR-KNRDQIV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 90 LATKADRDFKTGD--------FSGEQiKR----SIEGSLERLGLDHLQYVYIHDPENTT-FENVMGSggplevLQKFQEQ 156
Cdd:cd19147 81 IATKFTTDYKAYEvgkgkavnYCGNH-KRslhvSVRDSLRKLQTDWIDILYVHWWDYTTsIEEVMDS------LHILVQQ 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 950277055 157 GVIDHIGISGGPIdmlirYVETGAFSAVETH---------NRYTLLNRAAE 198
Cdd:cd19147 154 GKVLYLGVSDTPA-----WVVSAANYYATAHgktpfsvyqGRWNVLNRDFE 199
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
30-309 |
3.60e-14 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 71.28 E-value: 3.60e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 30 DMPE----TFQYSTSEEQALVTlrTAFESPINFIDTAAAYGegeSERRIGKAIQANGGLPAGYVLATKadrdFKTGDFSG 105
Cdd:cd19127 8 EMPAlglgVFQTPPEETADAVA--TALADGYRLIDTAAAYG---NEREVGEGIRRSGVDRSDIFVTTK----LWISDYGY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 106 EQIKRSIEGSLERLGLDHLQYVYIHDPENTTFENVMGSGGPLEvlqKFQEQGVIDHIGISGGPIDMLIRYVE-TG---AF 181
Cdd:cd19127 79 DKALRGFDASLRRLGLDYVDLYLLHWPVPNDFDRTIQAYKALE---KLLAEGRVRAIGVSNFTPEHLERLIDaTTvvpAV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 182 SAVETHNRYTllnraAEPLLDVASRRDVAVINAAPYGsGILAKGPDAyaryaySDAPPIVLERARMyAKVCQEYNVPLAA 261
Cdd:cd19127 156 NQVELHPYFS-----QKDLRAFHRRLGIVTQAWSPIG-GVMRYGASG------PTGPGDVLQDPTI-TGLAEKYGKTPAQ 222
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 950277055 262 AALQFSLRDLRIAstVVGMSKPERVAQTIELANYPIAPELWSAFDAIG 309
Cdd:cd19127 223 IVLRWHLQNGVSA--IPKSVHPERIAENIDIFDFALSAEDMAAIDALD 268
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
28-308 |
3.85e-14 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 72.19 E-value: 3.85e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 28 LGDMpeTFQYSTSEEQALVTLRTAFESPINFIDTAAAY-------GEGESERRIGKAIQANGGLPAgYVLATKADRDFKT 100
Cdd:PRK10625 18 LGTM--TFGEQNSEADAHAQLDYAVAQGINLIDVAEMYpvpprpeTQGLTETYIGNWLAKRGSREK-LIIASKVSGPSRN 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 101 GDFS--------GEQIKRSIEGSLERLGLDHLQYVYIHDPENTTfeNVMGSGG--------------PLEVLQKFQEQGV 158
Cdd:PRK10625 95 NDKGirpnqaldRKNIREALHDSLKRLQTDYLDLYQVHWPQRPT--NCFGKLGyswtdsapavslleTLDALAEQQRAGK 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 159 IDHIGISGGPIDMLIRYVETGAF----SAVETHNRYTLLNRAAE-PLLDVASRRDVAVINAAPYGSGIL-------AKGP 226
Cdd:PRK10625 173 IRYIGVSNETAFGVMRYLHLAEKhdlpRIVTIQNPYSLLNRSFEvGLAEVSQYEGVELLAYSCLAFGTLtgkylngAKPA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 227 DA-------YARYAYSDAPPIVLErarmYAKVCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELANYPIAP 299
Cdd:PRK10625 253 GArntlfsrFTRYSGEQTQKAVAA----YVDIAKRHGLDPAQMALAFVRRQPFVASTLLGATTMEQLKTNIESLHLTLSE 328
|
....*....
gi 950277055 300 ELWSAFDAI 308
Cdd:PRK10625 329 EVLAEIEAV 337
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
13-168 |
4.85e-14 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 71.69 E-value: 4.85e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 13 STGLLISPLCLGAAPLGDMPETFQYSTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQANGGLPAgYVLAT 92
Cdd:cd19146 6 TAGVRVSPLCLGAMSFGEAWKSMMGECDKETAFKLLDAFYEQGGNFIDTANNYQGEESERWVGEWMASRGNRDE-MVLAT 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 93 KADRDFKTGD-------FSGEQIKR---SIEGSLERLGLDHLQYVYIH--DpENTTFENVMGSggplevLQKFQEQGVID 160
Cdd:cd19146 85 KYTTGYRRGGpikiksnYQGNHAKSlrlSVEASLKKLQTSYIDILYVHwwD-YTTSIPELMQS------LNHLVAAGKVL 157
|
....*...
gi 950277055 161 HIGISGGP 168
Cdd:cd19146 158 YLGVSDTP 165
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
9-132 |
5.19e-14 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 71.34 E-value: 5.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 9 RPLGSTGLLISPLCLGAAPlgdmpeTFQYSTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQANGGLPAGY 88
Cdd:cd19142 4 RNLGKSGLRVSNVGLGTWS------TFSTAISEEQAEEIVTLAYENGINYFDTSDAFTSGQAETELGRILKKKGWKRSSY 77
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 950277055 89 VLATKADRDFKTGD--FSGEQIKRSIEGSLERLGLDHLQYVYIH--DP 132
Cdd:cd19142 78 IVSTKIYWSYGSEErgLSRKHIIESVRASLRRLQLDYIDIVIIHkaDP 125
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
13-306 |
5.55e-14 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 70.74 E-value: 5.55e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 13 STGLLISPLCLGAAPLGDMPETFQystSEEQALvtlRTAFESPINFIDTAAAYGEGESERRIGKAIqangglpAGY---- 88
Cdd:cd19138 6 PDGTKVPALGQGTWYMGEDPAKRA---QEIEAL---RAGIDLGMTLIDTAEMYGDGGSEELVGEAI-------RGRrdkv 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 89 -----VLATKADRdfktgdfsgEQIKRSIEGSLERLGLDHLQYVYIHDPENTTFENVMgsggplEVLQKFQEQGVIDHIG 163
Cdd:cd19138 73 flvskVLPSNASR---------QGTVRACERSLRRLGTDYLDLYLLHWRGGVPLAETV------AAMEELKKEGKIRAWG 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 164 ISG-GPIDMLIRYVETGAFSAVETHNRYTLLNRAAE-PLLDVASRRDVAVINAAPYGSG-ILAKGpdayaryaysdappi 240
Cdd:cd19138 138 VSNfDTDDMEELWAVPGGGNCAANQVLYNLGSRGIEyDLLPWCREHGVPVMAYSPLAQGgLLRRG--------------- 202
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 950277055 241 VLERARMyAKVCQEYNVPLAAAALQFSLRDlriaSTVVGM---SKPERVAQTIELANYPIAPELWSAFD 306
Cdd:cd19138 203 LLENPTL-KEIAARHGATPAQVALAWVLRD----GNVIAIpksGSPEHARENAAAADLELTEEDLAELD 266
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
34-226 |
6.97e-14 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 70.37 E-value: 6.97e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 34 TFQYStsEEQALVTLRTAFESPINFIDTAAAYGegeSERRIGKAIqANGGLPAGYV-LATKADRDfktgDFSGEQIKRSI 112
Cdd:cd19140 15 TYPLT--GEECTRAVEHALELGYRHIDTAQMYG---NEAQVGEAI-AASGVPRDELfLTTKVWPD----NYSPDDFLASV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 113 EGSLERLGLDHLQYVYIHDPENTtfenvMGSGGPLEVLQKFQEQGVIDHIGISGGPIDML---IRYVETGAFS-AVETHn 188
Cdd:cd19140 85 EESLRKLRTDYVDLLLLHWPNKD-----VPLAETLGALNEAQEAGLARHIGVSNFTVALLreaVELSEAPLFTnQVEYH- 158
|
170 180 190
....*....|....*....|....*....|....*...
gi 950277055 189 ryTLLNRAaePLLDVASRRDVAVINAAPYGSGILAKGP 226
Cdd:cd19140 159 --PYLDQR--KLLDAAREHGIALTAYSPLARGEVLKDP 192
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
9-294 |
4.36e-13 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 68.86 E-value: 4.36e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 9 RPLGSTGLLISPLCLGaaplgdMPETFQYSTSEEQALVTLRTAFESPINFIDTAAAYG--EGESERRIGKAIQANGglpA 86
Cdd:PRK09912 16 RYCGKSGLRLPALSLG------LWHNFGHVNALESQRAILRKAFDLGITHFDLANNYGppPGSAEENFGRLLREDF---A 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 87 GY----VLATKADRDFKTGDF-SGEQIK---RSIEGSLERLGLDHLQYVYIHD-PENTTFENVMGSggplevLQKFQEQG 157
Cdd:PRK09912 87 AYrdelIISTKAGYDMWPGPYgSGGSRKyllASLDQSLKRMGLEYVDIFYSHRvDENTPMEETASA------LAHAVQSG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 158 VIDHIGISGGPIDMLIRYVE---TGAFSAVETHNRYTLLNRAAEP--LLDVASRRDVAVINAAPYGSGIL---------- 222
Cdd:PRK09912 161 KALYVGISSYSPERTQKMVEllrEWKIPLLIHQPSYNLLNRWVDKsgLLDTLQNNGVGCIAFTPLAQGLLtgkylngipq 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 950277055 223 -------AKGPDAYARYAYSDAPpivLERARMYAKVCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTIELAN 294
Cdd:PRK09912 241 dsrmhreGNKVRGLTPKMLTEAN---LNSLRLLNEMAQQRGQSMAQMALSWLLKDERVTSVLIGASRAEQLEENVQALN 316
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
9-136 |
8.83e-13 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 67.86 E-value: 8.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 9 RPLGSTGLLISPLCLGAAPlgdmpeTFQYSTSEEQA--LVTLrtAFESPINFIDTAAAYGEGESERRIGKAIQANGGLPA 86
Cdd:cd19141 3 RNLGKSGLRVSCLGLGTWV------TFGSQISDEVAeeLVTL--AYENGINLFDTAEVYAAGKAEIVLGKILKKKGWRRS 74
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 950277055 87 GYVLATK---ADRDFKTGDFSGEQIKRSIEGSLERLGLDHLQYVYIHDPENTT 136
Cdd:cd19141 75 SYVITTKifwGGKAETERGLSRKHIIEGLKASLERLQLEYVDIVFANRPDPNT 127
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
9-290 |
1.17e-12 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 67.48 E-value: 1.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 9 RPLGSTGLLISPLCLGaaplgdMPETFQYSTSEEQALVTLRTAFESPINFIDTAAAYGE--GESERRIGKAIQANgglPA 86
Cdd:cd19150 3 RRCGKSGLKLPALSLG------LWHNFGDDTPLETQRAILRTAFDLGITHFDLANNYGPppGSAEENFGRILRED---FA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 87 GY----VLATKADRDFKTGDFsGEQIKR-----SIEGSLERLGLDHLQYVYIH--DPEnTTFENVMGSggplevlqkfqe 155
Cdd:cd19150 74 GYrdelIISTKAGYDMWPGPY-GEWGSRkyllaSLDQSLKRMGLDYVDIFYSHrfDPD-TPLEETMGA------------ 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 156 qgvIDHIGISGGPIdmlirYVETGAFSAVETHN-----------------RYTLLNRAAEP--LLDVASRRDVAVINAAP 216
Cdd:cd19150 140 ---LDHAVRSGKAL-----YVGISSYSPERTREaaailrelgtpllihqpSYNMLNRWVEEsgLLDTLQELGVGCIAFTP 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 217 YGSGILAK----GPDAYAR------YAYSDAPPIVLERARMYAKVCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERV 286
Cdd:cd19150 212 LAQGLLTDkylnGIPEGSRaskersLSPKMLTEANLNSIRALNEIAQKRGQSLAQMALAWVLRDGRVTSALIGASRPEQL 291
|
....
gi 950277055 287 AQTI 290
Cdd:cd19150 292 EENV 295
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
9-148 |
2.23e-12 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 66.55 E-value: 2.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 9 RPLGSTGLLISplCLGaapLGDMPeTFQYSTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQANGGLPAGY 88
Cdd:cd19160 6 RNLGKSGLRVS--CLG---LGTWV-TFGSQISDETAEDLLTVAYEHGVNLFDTAEVYAAGKAERTLGNILKSKGWRRSSY 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 950277055 89 VLATK----ADRDFKTGdFSGEQIKRSIEGSLERLGLDHLQYVyihdpenttFENVMGSGGPLE 148
Cdd:cd19160 80 VVTTKiywgGQAETERG-LSRKHIIEGLRGSLDRLQLEYVDIV---------FANRSDPNSPME 133
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
19-165 |
2.59e-12 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 66.20 E-value: 2.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 19 SPLCLGAAPLGDmpetfqySTSEEQALVTLRTAFESPINFIDTAAAYGE-------GESERRIGKAIQANGGLPAgYVLA 91
Cdd:cd19752 1 SELCLGTMYFGT-------RTDEETSFAILDRYVAAGGNFLDTANNYAFwteggvgGESERLIGRWLKDRGNRDD-VVIA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 92 TK---ADRDFKTGDF-----SGEQIKRSIEGSLERLGLDH--LQYVYIHDPeNTTFENVMgsggplEVLQKFQEQGVIDH 161
Cdd:cd19752 73 TKvgaGPRDPDGGPEspeglSAETIEQEIDKSLRRLGTDYidLYYAHVDDR-DTPLEETL------EAFNELVKAGKVRA 145
|
....
gi 950277055 162 IGIS 165
Cdd:cd19752 146 IGAS 149
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
14-223 |
3.11e-12 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 66.11 E-value: 3.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 14 TGLLISPLCLGAAPLGDMPEtfqySTSEEQALVTLRTAFESPINFIDTAAAYGEGE---SERRIGKAIQANGGLPAGYVL 90
Cdd:cd19077 1 NGKLVGPIGLGLMGLTWRPN----PTPDEEAFETMKAALDAGSNLWNGGEFYGPPDphaNLKLLARFFRKYPEYADKVVL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 91 ATK--ADRDFKTGDFSGEQIKRSIEGSLERLGLDhlQYVYIHDP----ENTTFENVMgsggplEVLQKFQEQGVIDHIGI 164
Cdd:cd19077 77 SVKggLDPDTLRPDGSPEAVRKSIENILRALGGT--KKIDIFEParvdPNVPIEETI------KALKELVKEGKIRGIGL 148
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 950277055 165 SGGPIDMLIRYVETGAFSAVETHnrYTLLNRAAEP--LLDVASRRDVAVINAAPYGSGILA 223
Cdd:cd19077 149 SEVSAETIRRAHAVHPIAAVEVE--YSLFSREIEEngVLETCAELGIPIIAYSPLGRGLLT 207
|
|
| PRK10376 |
PRK10376 |
putative oxidoreductase; Provisional |
42-218 |
7.89e-12 |
|
putative oxidoreductase; Provisional
Pssm-ID: 236676 [Multi-domain] Cd Length: 290 Bit Score: 64.61 E-value: 7.89e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 42 EQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQAnggLPAGYVLATK--ADRDFKTG---DFSGEQIKRSIEGSL 116
Cdd:PRK10376 40 DAAIAVLREAVALGVNHIDTSDFYGPHVTNQLIREALHP---YPDDLTIVTKvgARRGEDGSwlpAFSPAELRRAVHDNL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 117 ERLGLDHLQYVY------IHDPENTTFENvmgsggPLEVLQKFQEQGVIDHIGISggpiDMLIRYVETGAFSA--VETHN 188
Cdd:PRK10376 117 RNLGLDVLDVVNlrlmgdGHGPAEGSIEE------PLTVLAELQRQGLVRHIGLS----NVTPTQVAEARKIAeiVCVQN 186
|
170 180 190
....*....|....*....|....*....|
gi 950277055 189 RYTLLNRAAEPLLDVASRRDVAVINAAPYG 218
Cdd:PRK10376 187 HYNLAHRADDALIDALARDGIAYVPFFPLG 216
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
40-308 |
2.94e-11 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 62.57 E-value: 2.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 40 SEEQALVTLRTAFESPINFIDTAAAYGegeSERRIGKAIQANGgLPAGYVLATKadrDFKTGDFSGEQIKRSIEGSLERL 119
Cdd:cd19134 22 SDDEAERSVSAALEAGYRLIDTAAAYG---NEAAVGRAIAASG-IPRGELFVTT---KLATPDQGFTASQAACRASLERL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 120 GLDHLQYVYIHDPENTTFENVMGSGGplevLQKFQEQGVIDHIGISGGPIDMLIRYV----ETGAFSAVETHnryTLLNR 195
Cdd:cd19134 95 GLDYVDLYLIHWPAGREGKYVDSWGG----LMKLREEGLARSIGVSNFTAEHLENLIdltfFTPAVNQIELH---PLLNQ 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 196 AAepLLDVASRRDVAVINAAPYGSGILAKGPDAYAryaysdappIVLERARMYAKVCQEYNVPLAAAAlqfslrdlrias 275
Cdd:cd19134 168 AE--LRKVNAQHGIVTQAYSPLGVGRLLDNPAVTA---------IAAAHGRTPAQVLLRWSLQLGNVV------------ 224
|
250 260 270
....*....|....*....|....*....|...
gi 950277055 276 tVVGMSKPERVAQTIELANYPIAPELWSAFDAI 308
Cdd:cd19134 225 -ISRSSNPERIASNLDVFDFELTADHMDALDGL 256
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
34-187 |
4.16e-11 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 62.21 E-value: 4.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 34 TFQYSTSEEqALVTLRTAFESPINFIDTAAAYGegeSERRIGKAIQANGglpagyvlatkADRD--FKT-----GDFSGE 106
Cdd:cd19133 16 VFQIPDPEE-CERAVLEAIKAGYRLIDTAAAYG---NEEAVGRAIKKSG-----------IPREelFITtklwiQDAGYE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 107 QIKRSIEGSLERLGLDHLQYVYIHDPenttFENVMGSGGPLEVLQKfqeQGVIDHIGISGGPIDMLIRYVETG----AFS 182
Cdd:cd19133 81 KAKKAFERSLKRLGLDYLDLYLIHQP----FGDVYGAWRAMEELYK---EGKIRAIGVSNFYPDRLVDLILHNevkpAVN 153
|
....*
gi 950277055 183 AVETH 187
Cdd:cd19133 154 QIETH 158
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
34-165 |
4.00e-10 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 59.18 E-value: 4.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 34 TFQYsTSEEQALVTLRTAFESPINFIDTAAAYGegeSERRIGKAIQAnggLPAGYVLatKADRDFKTG-----DFSGEQI 108
Cdd:cd19136 8 TFRL-RGEEEVRQAVDAALKAGYRLIDTASVYR---NEADIGKALRD---LLPKYGL--SREDIFITSklapkDQGYEKA 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 950277055 109 KRSIEGSLERLGLDHLQYVYIH----------DPENTTFENvmgsgGPLEVLQKFQEQGVIDHIGIS 165
Cdd:cd19136 79 RAACLGSLERLGTDYLDLYLIHwpgvqglkpsDPRNAELRR-----ESWRALEDLYKEGKLRAIGVS 140
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
37-300 |
6.71e-10 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 58.65 E-value: 6.71e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 37 YSTSEEQALVTLRTAFESPINFIDTAAAYGegeSERRIGKAIqANGGLPagyvlatkadRD--FKTG-----DFSGEQIK 109
Cdd:cd19071 9 YKLKPEETAEAVLAALEAGYRHIDTAAAYG---NEAEVGEAI-RESGVP----------REelFITTklwptDHGYERVR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 110 RSIEGSLERLGLDHLQYVYIHDPenTTFENVMGSGGPLEV---LQKFQEQGVIDHIGISGGPIDMLIRYVETG----AFS 182
Cdd:cd19071 75 EALEESLKDLGLDYLDLYLIHWP--VPGKEGGSKEARLETwraLEELVDEGLVRSIGVSNFNVEHLEELLAAArikpAVN 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 183 AVETHnrytLLNRAAEpLLDVASRRDVAVINAAPYGSGILAkgpdayaryaysdappiVLERARMyAKVCQEYNVPLAAA 262
Cdd:cd19071 153 QIELH----PYLQQKE-LVEFCKEHGIVVQAYSPLGRGRRP-----------------LLDDPVL-KEIAKKYGKTPAQV 209
|
250 260 270
....*....|....*....|....*....|....*....
gi 950277055 263 ALQFSL-RDLriaSTVVGMSKPERVAQTIELANYPIAPE 300
Cdd:cd19071 210 LLRWALqRGV---VVIPKSSNPERIKENLDVFDFELSEE 245
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
9-136 |
1.01e-09 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 58.90 E-value: 1.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 9 RPLGSTGLLISplCLGaapLGDMPeTFQYSTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQANGGLPAGY 88
Cdd:cd19159 4 RNLGKSGLRVS--CLG---LGTWV-TFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSL 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 950277055 89 VLATKADRDFKTGDFSGEQIKRSIEG---SLERLGLDHLQYVYIHDPENTT 136
Cdd:cd19159 78 VITTKLYWGGKAETERGLSRKHIIEGlkgSLQRLQLEYVDVVFANRPDSNT 128
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
39-191 |
1.05e-09 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 58.15 E-value: 1.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 39 TSEEQALVTLRTAFESPINFIDTAAAYGegeSERRIGKAIQANGGLPAGYVLATKadrdFKTGDFSGEQIKRSIEGSLER 118
Cdd:cd19131 20 VSNDEAASAVREALEVGYRSIDTAAIYG---NEEGVGKAIRASGVPREELFITTK----LWNSDQGYDSTLRAFDESLRK 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 119 LGLDHLQYVYIHDPenttfenVMGSGGPLEV---LQKFQEQGVIDHIGISGGPIDMLIRYV-ETG---AFSAVETHNRYT 191
Cdd:cd19131 93 LGLDYVDLYLIHWP-------VPAQDKYVETwkaLIELKKEGRVKSIGVSNFTIEHLQRLIdETGvvpVVNQIELHPRFQ 165
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
9-290 |
1.14e-09 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 58.56 E-value: 1.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 9 RPLGSTGLLISPLCLGAAPlgdmpeTFQYSTSEEQALVTLRTAFESPINFIDTAAAYGEGESERRIGKAIQANGGLPAGY 88
Cdd:cd19158 4 RNLGKSGLRVSCLGLGTWV------TFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 89 VLATKADRDFKTGDFSGEQIKRSIEG---SLERLGLDHLQYVYIHDPE-NTTFENVmgsggpLEVLQKFQEQGVIDHIGI 164
Cdd:cd19158 78 VITTKIFWGGKAETERGLSRKHIIEGlkaSLERLQLEYVDVVFANRPDpNTPMEET------VRAMTHVINQGMAMYWGT 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 165 SG-GPIDMLIRYVETGAFSAVE---THNRYTLLNR--AAEPLLDVASRRDVAVINAAPYGSGILAKGPDA----YAR--- 231
Cdd:cd19158 152 SRwSSMEIMEAYSVARQFNLIPpicEQAEYHMFQRekVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSgippYSRasl 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 950277055 232 --YAYSDAPPIVLERARMYAK------VCQEYNVPLAAAALQFSLRDLRIASTVVGMSKPERVAQTI 290
Cdd:cd19158 232 kgYQWLKDKILSEEGRRQQAKlkelqaIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENI 298
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
13-300 |
1.14e-09 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 58.45 E-value: 1.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 13 STGLLISPLCLGaaplgdmpeTFQySTSEEQALVTLRTAFESPINFIDTAAAYGegeSERRIGKAIQ---ANGGLPAGYV 89
Cdd:cd19116 6 NDGNEIPAIALG---------TWK-LKDDEGVRQAVKHAIEAGYRHIDTAYLYG---NEAEVGEAIRekiAEGVVKREDL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 90 -LATKADRDFktgdFSGEQIKRSIEGSLERLGLDHLQYVYIHDPENTTFENVMGSGGPLEV-----------LQKFQEQG 157
Cdd:cd19116 73 fITTKLWNSY----HEREQVEPALRESLKRLGLDYVDLYLIHWPVAFKENNDSESNGDGSLsdidyletwrgMEDLVKLG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 158 VIDHIGISG---GPIDMLIRYVETG-AFSAVETHNRYTllnraAEPLLDVASRRDVAVINAAPYGSGILAKGPDAYARYa 233
Cdd:cd19116 149 LTRSIGVSNfnsEQINRLLSNCNIKpAVNQIEVHPTLT-----QEKLVAYCQSNGIVVMAYSPFGRLVPRGQTNPPPRL- 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 234 ysdAPPIVLERARMYAKvcqeynvplaaAALQFSLRDLrIASTVVGMSK---PERVAQTIELANYPIAPE 300
Cdd:cd19116 223 ---DDPTLVAIAKKYGK-----------TTAQIVLRYL-IDRGVVPIPKssnKKRIKENIDIFDFQLTPE 277
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
50-209 |
1.24e-09 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 58.11 E-value: 1.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 50 TAFESPINFIDTAAAYGEGESERRIGKAIQANGglPAGYVLATKadrdFKTG--DFSGEQIKRSIEGSLERLGLDHLQYV 127
Cdd:cd19103 40 KAMAAGLNLWDTAAVYGMGASEKILGEFLKRYP--REDYIISTK----FTPQiaGQSADPVADMLEGSLARLGTDYIDIY 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 128 YIHDPENTTfenvmgsgGPLEVLQKFQEQGVIDHIGISG---GPIDMLIRYVETGAF--SAVETHnrYTLLNRAAEP--L 200
Cdd:cd19103 114 WIHNPADVE--------RWTPELIPLLKSGKVKHVGVSNhnlAEIKRANEILAKAGVslSAVQNH--YSLLYRSSEEagI 183
|
....*....
gi 950277055 201 LDVASRRDV 209
Cdd:cd19103 184 LDYCKENGI 192
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
51-310 |
1.04e-07 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 52.23 E-value: 1.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 51 AFESPINFIDTAAAYGegeSERRIGKAIQANGGLPAGYVLATKADRdfktgdfSGEQIKRSIEGSLERLGLDHLQYVYIH 130
Cdd:cd19120 34 ALKAGFRHIDTAEMYG---NEKEVGEALKESGVPREDLFITTKVSP-------GIKDPREALRKSLAKLGVDYVDLYLIH 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 131 DPENTTFenvmGSGGPLEV---LQKFQEQGVIDHIGISGGPIDMLIRYVETG----AFSAVETHnryTLLNRAAEPLLDV 203
Cdd:cd19120 104 SPFFAKE----GGPTLAEAwaeLEALKDAGLVRSIGVSNFRIEDLEELLDTAkikpAVNQIEFH---PYLYPQQPALLEY 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 204 ASRRDVAVinaAPYGSgiLAkgpdAYARYAYSDAPPIVlerarmyAKVCQEYNVPLAAAALQFSL-RDLRIASTVvgmSK 282
Cdd:cd19120 177 CREHGIVV---SAYSP--LS----PLTRDAGGPLDPVL-------EKIAEKYGVTPAQVLLRWALqKGIVVVTTS---SK 237
|
250 260
....*....|....*....|....*...
gi 950277055 283 PERVAQTIELANYPIAPELWSAFDAIGY 310
Cdd:cd19120 238 EERMKEYLEAFDFELTEEEVEEIDKAGK 265
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
34-226 |
1.18e-07 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 51.84 E-value: 1.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 34 TFQYSTSEEQALVTlrTAFESPINFIDTAAAYGegeSERRIGKAIQANGGLPAGYVLATKADRDfktgDFSGEQIKRSIE 113
Cdd:cd19130 17 VFKVPPADTQRAVA--TALEVGYRHIDTAAIYG---NEEGVGAAIAASGIPRDELFVTTKLWND----RHDGDEPAAAFA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 114 GSLERLGLDHLQYVYIHDPenttfenVMGSGGPLEVLQKFQE---QGVIDHIGISGGPIDMLIRYVE----TGAFSAVET 186
Cdd:cd19130 88 ESLAKLGLDQVDLYLVHWP-------TPAAGNYVHTWEAMIElraAGRTRSIGVSNFLPPHLERIVAatgvVPAVNQIEL 160
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 950277055 187 HNRYTllNRAAEpllDVASRRDVAVINAAPYGSGILAKGP 226
Cdd:cd19130 161 HPAYQ--QRTIR---DWAQAHDVKIEAWSPLGQGKLLGDP 195
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
59-184 |
1.48e-07 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 51.50 E-value: 1.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 59 IDTAAAYgegESERRIGKAIQANGGLPAGYVLATKadrdFKTGDFSGEQIKRSIEGSLERLGLDHLQYVYIHDPenttfe 138
Cdd:cd19132 37 LDTAFNY---ENEGAVGEAVRRSGVPREELFVTTK----LPGRHHGYEEALRTIEESLYRLGLDYVDLYLIHWP------ 103
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 950277055 139 nVMGSGGPLEVLQKF---QEQGVIDHIGISGGP---IDMLIRyvETGAFSAV 184
Cdd:cd19132 104 -NPSRDLYVEAWQALieaREEGLVRSIGVSNFLpehLDRLID--ETGVTPAV 152
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
49-226 |
1.56e-06 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 48.50 E-value: 1.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 49 RTAFESPINFIDTAAAYgegESERRIGKAIQANGgLPAGYV-LATKadrdFKTGDFSGEQIKRSIEGSLERLGLDHLQYV 127
Cdd:cd19139 21 RTALELGYRHIDTAQIY---DNEAAVGQAIAESG-VPRDELfITTK----IWIDNLSKDKLLPSLEESLEKLRTDYVDLT 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 128 YIHDPentTFENVMGSGGPLEVLQKFQEQGVIDHIGISGGPIDMLIRYVETGAFSAVETH----NRYtLLNRAaepLLDV 203
Cdd:cd19139 93 LIHWP---SPNDEVPVEEYIGALAEAKEQGLTRHIGVSNFTIALLDEAIAVVGAGAIATNqielSPY-LQNRK---LVAH 165
|
170 180
....*....|....*....|...
gi 950277055 204 ASRRDVAVINAAPYGSGILAKGP 226
Cdd:cd19139 166 CKQHGIHVTSYMTLAYGKVLDDP 188
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
37-223 |
1.65e-06 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 48.74 E-value: 1.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 37 YSTSEEQALVTLRTAFESPINFIDTAAAYGEGES-ERRIGKAIQANGGLPAGYVLATKADRDFKTGDFSGEQIKRSIEGS 115
Cdd:cd19101 18 GIRDEDAAVRAMAAYVDAGLTTFDCADIYGPAEElIGEFRKRLRRERDAADDVQIHTKWVPDPGELTMTRAYVEAAIDRS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 116 LERLGLDHLQYVYIH--DPENTTFENVMGSggplevLQKFQEQGVIDHIGISGGPIDMLIRYVETGaFSAVETHNRYTLL 193
Cdd:cd19101 98 LKRLGVDRLDLVQFHwwDYSDPGYLDAAKH------LAELQEEGKIRHLGLTNFDTERLREILDAG-VPIVSNQVQYSLL 170
|
170 180 190
....*....|....*....|....*....|....
gi 950277055 194 NRAAE-PLLDVASRRDVAVInaaPYGS---GILA 223
Cdd:cd19101 171 DRRPEnGMAALCEDHGIKLL---AYGTlagGLLS 201
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
34-250 |
6.13e-06 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 47.11 E-value: 6.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 34 TFQYSTSEEQALVtlRTAFESPINFIDTAAAYGegeSERRIGKAIQ---ANGGLPAGYV-LATKAdrdfKTGDFSGEQIK 109
Cdd:cd19111 11 TYQSPPEEVRAAV--DYALFVGYRHIDTALSYQ---NEKAIGEALKwwlKNGKLKREEVfITTKL----PPVYLEFKDTE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 110 RSIEGSLERLGLDHLQYVYIHDPENTTFEnvmGSGGPLE-----------VLQKFQEQGVIDHIGISGGPIDMLIRYVet 178
Cdd:cd19111 82 KSLEKSLENLKLPYVDLYLIHHPCGFVNK---KDKGERElassdvtsvwrAMEALVSEGKVKSIGLSNFNPRQINKIL-- 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 950277055 179 gAFSAVETHNRYTLLNR--AAEPLLDVASRRDVAVINAAPYGSgilakgPDAYARYAYSDAP-----PIVLERARMYAK 250
Cdd:cd19111 157 -AYAKVKPSNLQLECHAylQQRELRKFCNKKNIVVTAYAPLGS------PGRANQSLWPDQPdlledPTVLAIAKELDK 228
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
40-165 |
6.24e-06 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 46.66 E-value: 6.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 40 SEEQALVTLRTAFESPINFIDTAAAYgegESERRIGKAIQANGGLPAGYVLATKADRDfktgDFSGEQIKRSIEGSLERL 119
Cdd:cd19126 21 DGDETERAVQTALENGYRSIDTAAIY---KNEEGVGEAIRESGVPREELFVTTKLWND----DQRARRTEDAFQESLDRL 93
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 950277055 120 GLDHLQYVYIHDPENTTFENVMgsggplEVLQKFQEQGVIDHIGIS 165
Cdd:cd19126 94 GLDYVDLYLIHWPGKDKFIDTW------KALEKLYASGKVKAIGVS 133
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
13-251 |
7.24e-06 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 46.55 E-value: 7.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 13 STGLLISPLCLGAAPLGdmpetfQYStsEEQALVTLRtafESPINFIDTAAAYGegeSERRIGKAIqANGGLPAGYV-LA 91
Cdd:cd19135 8 SNGVEMPILGLGTSHSG------GYS--HEAVVYALK---ECGYRHIDTAKRYG---CEELLGKAI-KESGVPREDLfLT 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 92 TKadrdFKTGDFSGEQIKRSIEGSLERLGLDHLQYVYIHDPenttfENVMGSGGPLEV-------LQKFQEQGVIDHIGI 164
Cdd:cd19135 73 TK----LWPSDYGYESTKQAFEASLKRLGVDYLDLYLLHWP-----DCPSSGKNVKETraetwraLEELYDEGLCRAIGV 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 165 SGGPIDMLIRYVETGAFSAVETHNRYTLLNRAAEpLLDVASRRDVAVINAAPygsgiLAKGPdayaryAYSDapPIVLER 244
Cdd:cd19135 144 SNFLIEHLEQLLEDCSVVPHVNQVEFHPFQNPVE-LIEYCRDNNIVFEGYCP-----LAKGK------ALEE--PTVTEL 209
|
....*..
gi 950277055 245 ARMYAKV 251
Cdd:cd19135 210 AKKYQKT 216
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
41-191 |
1.38e-05 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 45.84 E-value: 1.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 41 EEQALVTLRTAFESPINFIDTAAAYGegeSERRIGKAIQANGglpagyvlatkADRD--FKT-----GDFSGEQIKRSIE 113
Cdd:cd19157 23 GSEVVNAVKTALKNGYRSIDTAAIYG---NEEGVGKGIKESG-----------IPREelFITskvwnADQGYDSTLKAFE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 114 GSLERLGLDHLQYVYIHDPENTTFENVMgsggplEVLQKFQEQGVIDHIGISGGPI---DMLIRYVE-TGAFSAVETHNR 189
Cdd:cd19157 89 ASLERLGLDYLDLYLIHWPVKGKYKETW------KALEKLYKDGRVRAIGVSNFQVhhlEDLLADAEiVPMVNQVEFHPR 162
|
..
gi 950277055 190 YT 191
Cdd:cd19157 163 LT 164
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
37-187 |
6.19e-05 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 43.91 E-value: 6.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 37 YSTSEEQALVTLRTAFESPINFIDTAAAYGegeSERRIGKAIQANgGLPAGYVLATkadrdfkTGDFSGEQI--KRSIEG 114
Cdd:PRK11565 23 WQASNEEVITAIHKALEVGYRSIDTAAIYK---NEEGVGKALKEA-SVAREELFIT-------TKLWNDDHKrpREALEE 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 950277055 115 SLERLGLDHLQYVYIH--DPENTTFEnvmgsgGPLEVLQKFQEQGVIDHIGISGGPIDMLIRYV-ETG---AFSAVETH 187
Cdd:PRK11565 92 SLKKLQLDYVDLYLMHwpVPAIDHYV------EAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIdETGvtpVINQIELH 164
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
47-172 |
8.04e-05 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 43.47 E-value: 8.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 47 TLRTAFESPINFIDTAAAYGegeSERRIGKAIQANGGLPAGYVLATKadrdFKTGDFSGEQIKRSIEGSLERLGLDHLQY 126
Cdd:PRK11172 21 SVKTALELGYRAIDTAQIYD---NEAAVGQAIAESGVPRDELFITTK----IWIDNLAKDKLIPSLKESLQKLRTDYVDL 93
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 950277055 127 VYIHDPENttfenvmGSGGPLEV----LQKFQEQGVIDHIGISGGPIDML 172
Cdd:PRK11172 94 TLIHWPSP-------NDEVSVEEfmqaLLEAKKQGLTREIGISNFTIALM 136
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
42-226 |
1.02e-04 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 43.28 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 42 EQALVTLRTAFESPINFIDTAAAYgegESERRIGKAIQANGgLPAGYVLAT----KADRDFktgdfsgEQIKRSIEGSLE 117
Cdd:cd19156 23 AEAENAVKWAIEAGYRHIDTAAIY---KNEEGVGQGIRESG-VPREEVFVTtklwNSDQGY-------ESTLAAFEESLE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 118 RLGLDHLQYVYIHDPENTTFENVMgsggplEVLQKFQEQGVIDHIGISGGPI----DMLIRYVETGAFSAVETHnryTLL 193
Cdd:cd19156 92 KLGLDYVDLYLIHWPVKGKFKDTW------KAFEKLYKEKKVRAIGVSNFHEhhleELLKSCKVAPMVNQIELH---PLL 162
|
170 180 190
....*....|....*....|....*....|...
gi 950277055 194 NRaaEPLLDVASRRDVAVINAAPYGSGILAKGP 226
Cdd:cd19156 163 TQ--EPLRKFCKEKNIAVEAWSPLGQGKLLSNP 193
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
37-219 |
1.35e-04 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 42.78 E-value: 1.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 37 YSTSEEQALVTLRTAFESPINFIDTAAAYgegESERRIGKAIQANggLPAGYV------LATKAdrdfKTGDFSGEQIKR 110
Cdd:cd19154 20 WQSKGAEGITAVRTALKAGYRLIDTAFLY---QNEEAIGEALAEL--LEEGVVkredlfITTKL----WTHEHAPEDVEE 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 111 SIEGSLERLGLDHLQYVYIHDP--------ENTTFENVMGSGGPLEV------LQKFQEQGVIDHIGISGGPIDMLIRYV 176
Cdd:cd19154 91 ALRESLKKLQLEYVDLYLIHAPaafkddegESGTMENGMSIHDAVDVedvwrgMEKVYDEGLTKAIGVSNFNNDQIQRIL 170
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 950277055 177 ETG----AFSAVETHnrytlLNRAAEPLLDVASRRDVAVINAAPYGS 219
Cdd:cd19154 171 DNArvkpHNNQVECH-----LYFPQKELVEFCKKHNISVTSYATLGS 212
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
59-309 |
3.65e-04 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 41.56 E-value: 3.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 59 IDTAAAYGegeSERRIGKAIQAngGLPAGYVlatkaDRD--FKTG-----DFSGEQIKRSIEGSLERLGLDHLQYVYIHD 131
Cdd:cd19125 41 IDCAAIYG---NEKEIGKALKK--LFEDGVV-----KREdlFITSklwctDHAPEDVPPALEKTLKDLQLDYLDLYLIHW 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 132 PENTTFENVMgsGGPLEVLQ-----------KFQEQGVIDHIGISGGPIDMLIRYVETG----AFSAVETHNrytlLNRA 196
Cdd:cd19125 111 PVRLKKGAHM--PEPEEVLPpdipstwkameKLVDSGKVRAIGVSNFSVKKLEDLLAVArvppAVNQVECHP----GWQQ 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 197 AEpLLDVASRRDVAVINAAPYGSGilakgpdaYARYAYSD--APPIVlerarmyAKVCQEYNVPLAAAALQFSLRdlRIA 274
Cdd:cd19125 185 DK-LHEFCKSKGIHLSAYSPLGSP--------GTTWVKKNvlKDPIV-------TKVAEKLGKTPAQVALRWGLQ--RGT 246
|
250 260 270
....*....|....*....|....*....|....*
gi 950277055 275 STVVGMSKPERVAQTIELANYPIAPELWSAFDAIG 309
Cdd:cd19125 247 SVLPKSTNEERIKENIDVFDWSIPEEDFAKFSSIE 281
|
|
| AKR_AKR2C1 |
cd19114 |
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ... |
59-233 |
6.29e-04 |
|
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 41.00 E-value: 6.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 59 IDTAAAYG-EGESERRIGKAIQANGGLPAGYVLATKADRDFKtgdfSGEQIKRSIEGSLERLGLDHLQYVYIHDP----- 132
Cdd:cd19114 34 IDGALLYGnEAEVGRGIRKAIQEGLVKREDLFIVTKLWNNFH----GKDHVREAFDRQLKDYGLDYIDLYLIHFPipaay 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 133 ----ENTTFENVMGSGGPLEV-----------LQKFQEQGVIDHIGISGGPIDM---LIRYVETG-AFSAVETHNrYTLL 193
Cdd:cd19114 110 vdpaENYPFLWKDKELKKFPLeqspmqecwreMEKLVDAGLVRNIGIANFNVQLildLLTYAKIKpAVLQIEHHP-YLQQ 188
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 950277055 194 NRaaepLLDVASRRDVAVINAAPYGSGILAKGPDAYARYA 233
Cdd:cd19114 189 KR----LIDWAKKQGIQITAYSSFGNAVYTKVTKHLKHFT 224
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
50-165 |
1.08e-03 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 40.17 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 50 TAFESPINFIDTAAAYGegeSERRIGKAIQANGGLPAGYVLATKADRDFKtgdfsgEQIKRSIEGSLERLGLDHLQYVYI 129
Cdd:cd19117 35 AALKAGYRHIDTAAIYG---NEEEVGQGIKDSGVPREEIFITTKLWCTWH------RRVEEALDQSLKKLGLDYVDLYLM 105
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 950277055 130 H-----DPENTTFENVMGSGGPL-----------EVLQKFQEQGVIDHIGIS 165
Cdd:cd19117 106 HwpvplDPDGNDFLFKKDDGTKDhepdwdfiktwELMQKLPATGKVKAIGVS 157
|
|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
60-300 |
1.38e-03 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 39.78 E-value: 1.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 60 DTAAAYGegeSERRIGKAIQAngGLPAGYVlatKADRDFKTGDF---SGEQIKRSIEGSLERLGLDHLQYVYIHDPENT- 135
Cdd:cd19112 42 DCAADYK---NEKEVGEALAE--AFKTGLV---KREDLFITTKLwnsDHGHVIEACKDSLKKLQLDYLDLYLVHFPVATk 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 136 -----TFENVMGSGGPLEV------------LQKFQEQGVIDHIGISGGPI----DMLIRYVETGAFSAVETHNRYTlln 194
Cdd:cd19112 114 htgvgTTGSALGEDGVLDIdvtislettwhaMEKLVSAGLVRSIGISNYDIfltrDCLAYSKIKPAVNQIETHPYFQ--- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 195 raAEPLLDVASRRDVAVINAAPYGSGIlakgpdAYARYAYSDAP---PIVLERARMYAKVcqeynvpLAAAALQFSLRdl 271
Cdd:cd19112 191 --RDSLVKFCQKHGISVTAHTPLGGAA------ANAEWFGSVSPlddPVLKDLAKKYGKS-------AAQIVLRWGIQ-- 253
|
250 260
....*....|....*....|....*....
gi 950277055 272 RIASTVVGMSKPERVAQTIELANYPIAPE 300
Cdd:cd19112 254 RNTAVIPKSSKPERLKENIDVFDFQLSKE 282
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
47-132 |
3.07e-03 |
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Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 38.59 E-value: 3.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 47 TLRTAFESPINFIDTAAAYgegESERRIGKAIQAngGLPAGYV------LATKadrdFKTGDFSGEQIKRSIEGSLERLG 120
Cdd:cd19129 24 AVKAALEAGFRHFDCAERY---RNEAEVGEAMQE--VFKAGKIrredlfVTTK----LWNTNHRPERVKPAFEASLKRLQ 94
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90
....*....|..
gi 950277055 121 LDHLQYVYIHDP 132
Cdd:cd19129 95 LDYLDLYLIHTP 106
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| AKR_unchar |
cd19098 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
19-264 |
3.76e-03 |
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uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381324 [Multi-domain] Cd Length: 318 Bit Score: 38.48 E-value: 3.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 19 SPLCLGAAPLG-----------DMPETFQYSTSEEQALVTLRTAFESPINFIDTAAAYgeGESERRIGKAIQANGGLPAG 87
Cdd:cd19098 1 PRLGLGLAALGrpgyinlghaaDLGSGRSVEAMRAHTHAVLDAAWAAGVRYFDAARSY--GRAEEFLGSWLRSRNIAPDA 78
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 88 YVLATK------ADRDFKTG-----DFSGEQIKRSIEGSLERLGlDHLQYVYIHdpeNTTFEN-VMGSGGPLEVLQKFQE 155
Cdd:cd19098 79 VFVGSKwgytytADWQVDAAvhevkDHSLARLLKQWEETRSLLG-KHLDLYQIH---SATLESgVLEDADVLAALAELKA 154
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170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950277055 156 QGVidHIGIS-GGP--IDMLIRYVET---GA--FSAVE-THNrytLLNRAAEPLLDVASRRDVAVINAAPYGSGILAKGP 226
Cdd:cd19098 155 EGV--KIGLSlSGPqqAETLRRALEIeidGArlFDSVQaTWN---LLEQSAGEALEEAHEAGMGVIVKEALANGRLTDRN 229
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250 260 270
....*....|....*....|....*....|....*...
gi 950277055 227 DAyaryaysdapPIVLERARMYAKVCQEYNVPLAAAAL 264
Cdd:cd19098 230 PS----------PELAPLMAVLKAVADRLGVTPDALAL 257
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