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Conserved domains on  [gi|950436382|ref|WP_057360326|]
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putative lipid II flippase FtsW [Mycobacterium tuberculosis]

Protein Classification

putative peptidoglycan glycosyltransferase FtsW( domain architecture ID 10021166)

putative peptidoglycan glycosyltransferase FtsW (or cell division protein FtsW) is a peptidoglycan polymerase that is essential for cell division

EC:  2.4.1.129
Gene Ontology:  GO:0008955|GO:0051301
PubMed:  30692671

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ftsW TIGR02614
cell division protein FtsW; This family consists of FtsW, an integral membrane protein with ...
58-412 1.40e-139

cell division protein FtsW; This family consists of FtsW, an integral membrane protein with ten transmembrane segments. In general, it is one of two paralogs involved in peptidoglycan biosynthesis, the other being RodA, and is essential for cell division. All members of the seed alignment for this model are encoded in operons for the biosynthesis of UDP-N-acetylmuramoyl-pentapeptide, a precursor of murein (peptidoglycan). The FtsW designation is not used in endospore-forming bacterial (e.g. Bacillus subtilis), where the member of this family is designated SpoVE and three or more RodA/FtsW/SpoVE family paralogs are present. SpoVE acts in spore cortex formation and is dispensible for growth. Biological rolls for FtsW in cell division include recruitment of penicillin-binding protein 3 to the division site. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division]


:

Pssm-ID: 274232  Cd Length: 356  Bit Score: 406.95  E-value: 1.40e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382   58 HLIIAVAALLTTLGLIMVLSASAVRSYDDDGSAWVIFGKQVLWTLVGLIGGYVCLRMSVRFMRRIAFSGFAITIVMLVLV 137
Cdd:TIGR02614   2 RLLLFVVLLLLGIGLVMVYSASAAVALRLGGNPFYFLKRQLFYALLGLILMFVASRLPLRFWRKLSVPILLIAIVLLVLV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382  138 LVPGIGKEANGSRGWFVVAGFSMQPSELAKMAFAIWGAHLLAARRMERASLREMLIPLVPAAVVALALIVAQPDLGQTVS 217
Cdd:TIGR02614  82 LIPGIGKEVNGARRWIGLGGFSIQPSEFAKLALIIYLAWYLARKQKEVKSFLKFLPPLAVLGLLVGLLLLLQPDFGTTVV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382  218 MGIILLGLLWYAGLPLRVFLSSLAAVVVSAAILAVSAGYRSDRVRSWLNPENDPQDSGYQARQAKFALAQGGIFGDGLGQ 297
Cdd:TIGR02614 162 IFFITLGMLFLAGAPLRYFALLLLLGLLGGAILIVSSPYRMRRILSFLDPWADPFGSGYQLTQSLIALGSGGLFGVGLGN 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382  298 GVAKWNYLPNAHNDFIFAIIGEELGLVGALGLLGLFGLFAYTGMRIASRSADPFLRLLTATTTLWVLGQAFINIGYVIGL 377
Cdd:TIGR02614 242 SVQKLFYLPEAHTDFIFAVIGEELGFIGVLIVILLFAFLVWRGLRIALRAEDLFGRYLAAGITIWIGLQAFINIGVVLGL 321
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 950436382  378 LPVTGLQLPLISAGGTSTAATLSLIGIIANAARHE 412
Cdd:TIGR02614 322 LPTKGLTLPFISYGGSSLVATMIAIGLLLNISRER 356
 
Name Accession Description Interval E-value
ftsW TIGR02614
cell division protein FtsW; This family consists of FtsW, an integral membrane protein with ...
58-412 1.40e-139

cell division protein FtsW; This family consists of FtsW, an integral membrane protein with ten transmembrane segments. In general, it is one of two paralogs involved in peptidoglycan biosynthesis, the other being RodA, and is essential for cell division. All members of the seed alignment for this model are encoded in operons for the biosynthesis of UDP-N-acetylmuramoyl-pentapeptide, a precursor of murein (peptidoglycan). The FtsW designation is not used in endospore-forming bacterial (e.g. Bacillus subtilis), where the member of this family is designated SpoVE and three or more RodA/FtsW/SpoVE family paralogs are present. SpoVE acts in spore cortex formation and is dispensible for growth. Biological rolls for FtsW in cell division include recruitment of penicillin-binding protein 3 to the division site. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division]


Pssm-ID: 274232  Cd Length: 356  Bit Score: 406.95  E-value: 1.40e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382   58 HLIIAVAALLTTLGLIMVLSASAVRSYDDDGSAWVIFGKQVLWTLVGLIGGYVCLRMSVRFMRRIAFSGFAITIVMLVLV 137
Cdd:TIGR02614   2 RLLLFVVLLLLGIGLVMVYSASAAVALRLGGNPFYFLKRQLFYALLGLILMFVASRLPLRFWRKLSVPILLIAIVLLVLV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382  138 LVPGIGKEANGSRGWFVVAGFSMQPSELAKMAFAIWGAHLLAARRMERASLREMLIPLVPAAVVALALIVAQPDLGQTVS 217
Cdd:TIGR02614  82 LIPGIGKEVNGARRWIGLGGFSIQPSEFAKLALIIYLAWYLARKQKEVKSFLKFLPPLAVLGLLVGLLLLLQPDFGTTVV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382  218 MGIILLGLLWYAGLPLRVFLSSLAAVVVSAAILAVSAGYRSDRVRSWLNPENDPQDSGYQARQAKFALAQGGIFGDGLGQ 297
Cdd:TIGR02614 162 IFFITLGMLFLAGAPLRYFALLLLLGLLGGAILIVSSPYRMRRILSFLDPWADPFGSGYQLTQSLIALGSGGLFGVGLGN 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382  298 GVAKWNYLPNAHNDFIFAIIGEELGLVGALGLLGLFGLFAYTGMRIASRSADPFLRLLTATTTLWVLGQAFINIGYVIGL 377
Cdd:TIGR02614 242 SVQKLFYLPEAHTDFIFAVIGEELGFIGVLIVILLFAFLVWRGLRIALRAEDLFGRYLAAGITIWIGLQAFINIGVVLGL 321
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 950436382  378 LPVTGLQLPLISAGGTSTAATLSLIGIIANAARHE 412
Cdd:TIGR02614 322 LPTKGLTLPFISYGGSSLVATMIAIGLLLNISRER 356
FTSW_RODA_SPOVE pfam01098
Cell cycle protein; This entry includes the following members; FtsW, RodA, SpoVE
57-412 1.80e-137

Cell cycle protein; This entry includes the following members; FtsW, RodA, SpoVE


Pssm-ID: 426047  Cd Length: 356  Bit Score: 401.64  E-value: 1.80e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382   57 FHLIIAVAALLTTLGLIMVLSASAVRSYDDDGSAWVIFGKQVLWTLVGLIGGYVCLRMSVRFMRRIAFSGFAITIVMLVL 136
Cdd:pfam01098   1 RRLLFIVLLLLGALGLVMVYSASAVTSLVLFGDSFFFFKRQLVYLLLGFIAFWVLLRIPLRFLRKWAFYLFIIGLLLLVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382  137 VLVpgIGKEANGSRGWFVVAGFSMQPSELAKMAFAIWGAHLLAAR-RMERASLREMLIPLVpAAVVALALIVAQPDLGQT 215
Cdd:pfam01098  81 VFV--IGPSANGAKRWIRLGGFSIQPSEFMKIALTLFLAAYLSRKpDNVRPRLRGFLPPLV-IIALAAGLILLQPDLGTA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382  216 VSMGIILLGLLWYAGLPLRVFLSSLAAVVVSAAILAVSAGYRSDRVRSWLNPENDPQDSGYQARQAKFALAQGGIFGDGL 295
Cdd:pfam01098 158 VLLGIILLVMLFLSGLSWRLFIALVLIGVSPIVWLILLEDYQIKRVTSFLDPFKDPLGSGYQIIQSLIAIGSGGIFGKGL 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382  296 GQGVAKWNYLPNAHNDFIFAIIGEELGLVGALGLLGLFGLFAYTGMRIASRSADPFLRLLTATTTLWVLGQAFINIGYVI 375
Cdd:pfam01098 238 GNGQQKLGYLPEAHTDFIFAVIGEELGFVGVLILLALFGLLIYRGLRIARRARDRFGSLLAVGISLLIFIQSFINIGMVS 317
                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 950436382  376 GLLPVTGLQLPLISAGGTSTAATLSLIGIIANAARHE 412
Cdd:pfam01098 318 GLLPVTGLPLPFFSYGGSSLLATLALFGILLNISREL 354
FtsW COG0772
Peptodoglycan polymerase FtsW/RodA/SpoVE [Cell cycle control, cell division, chromosome ...
58-415 2.15e-118

Peptodoglycan polymerase FtsW/RodA/SpoVE [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440535  Cd Length: 371  Bit Score: 353.26  E-value: 2.15e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382  58 HLIIAVAALLTTLGLIMVLSASAVRSYDDDGSAWVIFGKQVLWTLVGLIGGYVCLRMSVRFMRRIAFSGFAITIVMLVLV 137
Cdd:COG0772   15 WLLLLLVLLLLGIGLVMVYSASSALAARKGGDPFYFFKRQLIWLLLGLVLMLVVSRIDYRRLRRLAYPLYLLGLVLLLLV 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382 138 LVpgIGKEANGSRGWFVVAGFSMQPSELAKMAFAIWGAHLLAARRMERASLREMLIPLVPAAVVALaLIVAQPDLGQTVS 217
Cdd:COG0772   95 LL--FGTEVNGARRWISLGGFSFQPSEFAKLALILFLASYLSRKRDKLKDLKGLLPPLLLIGLPVG-LILLQPDLGTALV 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382 218 MGIILLGLLWYAGLPLRVFLSSLAAVVVSAAILAVSAGYRSDRVRSWLNPENDPQDSGYQARQAKFALAQGGIFGDGLGQ 297
Cdd:COG0772  172 LFAIFLGMLFVAGLPWKYLLGLLLLGVAAAVLLILLKPYQRARILAFLDPWADPLGAGYQIIQSLIAIGSGGLFGKGLGN 251
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382 298 GVAKWNYLPNAHNDFIFAIIGEELGLVGALGLLGLFGLFAYTGMRIASRSADPFLRLLTATTTLWVLGQAFINIGYVIGL 377
Cdd:COG0772  252 GTQKLGYLPEAHTDFIFAVIGEELGFIGALLVLLLFLLLIYRGLRIALRARDPFGRLLAAGIASLIFFQAFINIGMVTGL 331
                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 950436382 378 LPVTGLQLPLISAGGTSTAATLSLIGIIANAARHEPEA 415
Cdd:COG0772  332 LPVTGVPLPFISYGGSSLLANMIALGLLLSISRRRRRA 369
PRK10774 PRK10774
cell division protein FtsW; Provisional
67-394 3.90e-49

cell division protein FtsW; Provisional


Pssm-ID: 182719  Cd Length: 404  Bit Score: 174.20  E-value: 3.90e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382  67 LTTLGLIMVLSASAVRSYDDDGSAWVIFGKQVLWTLVGLIGGYVCLRMSVRFMRRIAFSGFAITIVMLVLVLVpgIGKEA 146
Cdd:PRK10774  45 LAAIGFVMVTSASMPVGQRLANDPFLFAKRDAVYLILAFGLALITLRLPMEFWQRYSATMLLGSIIMLLIVLV--VGSSV 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382 147 NGSRGWFVVAGFSMQPSELAKMAFAIWGAHLLAARRME-RASLREMLIPLvpAAVVALA-LIVAQPDLGQTVSMGIILLG 224
Cdd:PRK10774 123 NGASRWIALGPLRIQPAELTKLSLFCYLANYLVRKVDEvRNNFWGFLKPM--GVMLVLAvLLLAQPDLGTVVVLFVTTLA 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382 225 LLWYAGLPLRVFLSSLAAVVVSAAILAVSAGYRSDRVRSWLNPENDPQDSGYQARQAKFALAQGGIFGDGLGQGVAKWNY 304
Cdd:PRK10774 201 MLFLAGAKLWQFIAIIGMGISAVVLLILAEPYRIRRVTSFWNPWEDPFGSGYQLTQSLMAFGRGELWGQGLGNSVQKLEY 280
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382 305 LPNAHNDFIFAIIGEELGLVGALGLLGLFGLFAYTGMRIASRSAD---PFLRLLTATTTLWVLGQAFINIGYVIGLLPVT 381
Cdd:PRK10774 281 LPEAHTDFIFSIIGEELGYIGVVLALLMVFFVAFRAMSIGRKALEidqRFSGFLACSIGIWFSFQALVNVGAAAGMLPTK 360
                        330
                 ....*....|...
gi 950436382 382 GLQLPLISAGGTS 394
Cdd:PRK10774 361 GLTLPLISYGGSS 373
RodA_shape NF037961
rod shape-determining protein RodA; Proteins of this family are members of the FtsW/RodA/SpoVE ...
59-394 5.33e-27

rod shape-determining protein RodA; Proteins of this family are members of the FtsW/RodA/SpoVE superfamily. It has been reported that RodA proteins play important roles in maintaining cell shape and antibiotic resistance in bacteria.


Pssm-ID: 411566  Cd Length: 415  Bit Score: 113.07  E-value: 5.33e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382  59 LIIAVAALLTTLGLIMVLSAS---AVRSYDDDGSawvIFGKQVLWTLVGLIGGYVCLRMSVRFMRRiaFSGFAITIVMLV 135
Cdd:NF037961   3 ITILLYLLLVGFGWLNIYSAShtgESTSIFDFSQ---IYGKQLIFIGLSFVLIILILAIEAKFYER--FSSIIYIISLLS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382 136 LVLVPGIGKEANGSRGWFVVAGFSMQPSELAKMAFAIWGAHLLAARRME----RASLREMLIPLVPAAvvalaLIVAQPD 211
Cdd:NF037961  78 LLGLFIFGKTINGATSWYAIGGFTLQPSEFAKAATALALAKYLSDIQTDikrfKDQLKAFAIILIPAI-----LILLQPD 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382 212 LGQTV---SMGIIL------LGLLWYAGLPLRVFLSSLA----AVVVSAAILAVSAGYRS-------------------- 258
Cdd:NF037961 153 AGSALvyfAFFFVLyreglpLIYLIIGFILILLFVLTLKfgpiWVLIIAALLIFLYYFLKkkkkppilkiiiillicilf 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382 259 -----------------DRVRSWLNPENDP-------QDSGYQARQAKFALAQGGIFGDGLGQGV-AKWNYLPNAHNDFI 313
Cdd:NF037961 233 sfsvnfvydnvleqhhrDRFSLWLGLEKDPekleqmkKTIGYNTNQSEKAISSGGFTGKGFLEGTrTKGNFVPEQHTDYI 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382 314 FAIIGEELGLVGALGLLGLFGLFAYTGMRIASRSADPFLRLLTATTTLWVLGQAFINIGYVIGLLPVTGLQLPLISAGGT 393
Cdd:NF037961 313 FSTVGEEWGFLGSSLVVLLFVLLLLRIIYLAERQKSQFSRVYGYSVASILFIHFFINIGMVIGLIPTIGIPLPFFSYGGS 392

                 .
gi 950436382 394 S 394
Cdd:NF037961 393 G 393
 
Name Accession Description Interval E-value
ftsW TIGR02614
cell division protein FtsW; This family consists of FtsW, an integral membrane protein with ...
58-412 1.40e-139

cell division protein FtsW; This family consists of FtsW, an integral membrane protein with ten transmembrane segments. In general, it is one of two paralogs involved in peptidoglycan biosynthesis, the other being RodA, and is essential for cell division. All members of the seed alignment for this model are encoded in operons for the biosynthesis of UDP-N-acetylmuramoyl-pentapeptide, a precursor of murein (peptidoglycan). The FtsW designation is not used in endospore-forming bacterial (e.g. Bacillus subtilis), where the member of this family is designated SpoVE and three or more RodA/FtsW/SpoVE family paralogs are present. SpoVE acts in spore cortex formation and is dispensible for growth. Biological rolls for FtsW in cell division include recruitment of penicillin-binding protein 3 to the division site. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division]


Pssm-ID: 274232  Cd Length: 356  Bit Score: 406.95  E-value: 1.40e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382   58 HLIIAVAALLTTLGLIMVLSASAVRSYDDDGSAWVIFGKQVLWTLVGLIGGYVCLRMSVRFMRRIAFSGFAITIVMLVLV 137
Cdd:TIGR02614   2 RLLLFVVLLLLGIGLVMVYSASAAVALRLGGNPFYFLKRQLFYALLGLILMFVASRLPLRFWRKLSVPILLIAIVLLVLV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382  138 LVPGIGKEANGSRGWFVVAGFSMQPSELAKMAFAIWGAHLLAARRMERASLREMLIPLVPAAVVALALIVAQPDLGQTVS 217
Cdd:TIGR02614  82 LIPGIGKEVNGARRWIGLGGFSIQPSEFAKLALIIYLAWYLARKQKEVKSFLKFLPPLAVLGLLVGLLLLLQPDFGTTVV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382  218 MGIILLGLLWYAGLPLRVFLSSLAAVVVSAAILAVSAGYRSDRVRSWLNPENDPQDSGYQARQAKFALAQGGIFGDGLGQ 297
Cdd:TIGR02614 162 IFFITLGMLFLAGAPLRYFALLLLLGLLGGAILIVSSPYRMRRILSFLDPWADPFGSGYQLTQSLIALGSGGLFGVGLGN 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382  298 GVAKWNYLPNAHNDFIFAIIGEELGLVGALGLLGLFGLFAYTGMRIASRSADPFLRLLTATTTLWVLGQAFINIGYVIGL 377
Cdd:TIGR02614 242 SVQKLFYLPEAHTDFIFAVIGEELGFIGVLIVILLFAFLVWRGLRIALRAEDLFGRYLAAGITIWIGLQAFINIGVVLGL 321
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 950436382  378 LPVTGLQLPLISAGGTSTAATLSLIGIIANAARHE 412
Cdd:TIGR02614 322 LPTKGLTLPFISYGGSSLVATMIAIGLLLNISRER 356
FTSW_RODA_SPOVE pfam01098
Cell cycle protein; This entry includes the following members; FtsW, RodA, SpoVE
57-412 1.80e-137

Cell cycle protein; This entry includes the following members; FtsW, RodA, SpoVE


Pssm-ID: 426047  Cd Length: 356  Bit Score: 401.64  E-value: 1.80e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382   57 FHLIIAVAALLTTLGLIMVLSASAVRSYDDDGSAWVIFGKQVLWTLVGLIGGYVCLRMSVRFMRRIAFSGFAITIVMLVL 136
Cdd:pfam01098   1 RRLLFIVLLLLGALGLVMVYSASAVTSLVLFGDSFFFFKRQLVYLLLGFIAFWVLLRIPLRFLRKWAFYLFIIGLLLLVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382  137 VLVpgIGKEANGSRGWFVVAGFSMQPSELAKMAFAIWGAHLLAAR-RMERASLREMLIPLVpAAVVALALIVAQPDLGQT 215
Cdd:pfam01098  81 VFV--IGPSANGAKRWIRLGGFSIQPSEFMKIALTLFLAAYLSRKpDNVRPRLRGFLPPLV-IIALAAGLILLQPDLGTA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382  216 VSMGIILLGLLWYAGLPLRVFLSSLAAVVVSAAILAVSAGYRSDRVRSWLNPENDPQDSGYQARQAKFALAQGGIFGDGL 295
Cdd:pfam01098 158 VLLGIILLVMLFLSGLSWRLFIALVLIGVSPIVWLILLEDYQIKRVTSFLDPFKDPLGSGYQIIQSLIAIGSGGIFGKGL 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382  296 GQGVAKWNYLPNAHNDFIFAIIGEELGLVGALGLLGLFGLFAYTGMRIASRSADPFLRLLTATTTLWVLGQAFINIGYVI 375
Cdd:pfam01098 238 GNGQQKLGYLPEAHTDFIFAVIGEELGFVGVLILLALFGLLIYRGLRIARRARDRFGSLLAVGISLLIFIQSFINIGMVS 317
                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 950436382  376 GLLPVTGLQLPLISAGGTSTAATLSLIGIIANAARHE 412
Cdd:pfam01098 318 GLLPVTGLPLPFFSYGGSSLLATLALFGILLNISREL 354
FtsW COG0772
Peptodoglycan polymerase FtsW/RodA/SpoVE [Cell cycle control, cell division, chromosome ...
58-415 2.15e-118

Peptodoglycan polymerase FtsW/RodA/SpoVE [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440535  Cd Length: 371  Bit Score: 353.26  E-value: 2.15e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382  58 HLIIAVAALLTTLGLIMVLSASAVRSYDDDGSAWVIFGKQVLWTLVGLIGGYVCLRMSVRFMRRIAFSGFAITIVMLVLV 137
Cdd:COG0772   15 WLLLLLVLLLLGIGLVMVYSASSALAARKGGDPFYFFKRQLIWLLLGLVLMLVVSRIDYRRLRRLAYPLYLLGLVLLLLV 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382 138 LVpgIGKEANGSRGWFVVAGFSMQPSELAKMAFAIWGAHLLAARRMERASLREMLIPLVPAAVVALaLIVAQPDLGQTVS 217
Cdd:COG0772   95 LL--FGTEVNGARRWISLGGFSFQPSEFAKLALILFLASYLSRKRDKLKDLKGLLPPLLLIGLPVG-LILLQPDLGTALV 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382 218 MGIILLGLLWYAGLPLRVFLSSLAAVVVSAAILAVSAGYRSDRVRSWLNPENDPQDSGYQARQAKFALAQGGIFGDGLGQ 297
Cdd:COG0772  172 LFAIFLGMLFVAGLPWKYLLGLLLLGVAAAVLLILLKPYQRARILAFLDPWADPLGAGYQIIQSLIAIGSGGLFGKGLGN 251
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382 298 GVAKWNYLPNAHNDFIFAIIGEELGLVGALGLLGLFGLFAYTGMRIASRSADPFLRLLTATTTLWVLGQAFINIGYVIGL 377
Cdd:COG0772  252 GTQKLGYLPEAHTDFIFAVIGEELGFIGALLVLLLFLLLIYRGLRIALRARDPFGRLLAAGIASLIFFQAFINIGMVTGL 331
                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 950436382 378 LPVTGLQLPLISAGGTSTAATLSLIGIIANAARHEPEA 415
Cdd:COG0772  332 LPVTGVPLPFISYGGSSLLANMIALGLLLSISRRRRRA 369
spoVE TIGR02615
stage V sporulation protein E; This model represents an exception within the members of the ...
59-410 2.91e-69

stage V sporulation protein E; This model represents an exception within the members of the FtsW model TIGR02614. This exception occurs only in endospore-forming genera such as Bacillus, Geobacillus, and Oceanobacillus. Like FtsW, members are found in a peptidoglycan operon context, but in these genera they part of a larger set of paralogs (not just the pair FtsW and RodA) and are required specifically for sporulation, not for viability. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Sporulation and germination]


Pssm-ID: 131664  Cd Length: 354  Bit Score: 226.19  E-value: 2.91e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382   59 LIIAVAALLTTLGLIMVLSASAVRSYDDDGSAWVIFGKQVLWTLVGLIGGYVCLRMSVRFMRRIAFSGFAITIVMLVLVL 138
Cdd:TIGR02615   3 LLLIVIMLLVAIGVVMVYSASAYWAEYKFNDSFYFLKRQLLWAILGVFAMFFTMNIDYHTWKRWAKMLMVICFVLLLLVL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382  139 VPGIGKEANGSRGWFVVAGFSMQPSELAKMAFAIWGAHLLAARRMERASLREMLIPLVPAAVVALALIVAQPDLGQTVSM 218
Cdd:TIGR02615  83 IPGVGMERNGARRWIGVGAFSIQPSEIAKYALIIYLAKSLSEKQEYITSFRKGVIPYLLLAGFAFGLIMLQPNLSTATVI 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382  219 GIILLGLLWYAGLPLRVFLSSLAAVVVSAAILAVSAGYRSDRVRSWLNPENDPQDSGYQARQAKFALAQGGIFGDGLGQG 298
Cdd:TIGR02615 163 VMVCFIMLFVAGARLSHFIALVGIGISGGVALILSAPFRIGRILSFLNPWEDPLGSGYQIIQSLYALGSGGLFGVGLGQS 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382  299 VAKWNYLPNAHNDFIFAIIGEELGLVGALGLLGLFGLFAYTGMRIASRSADPFLRLLTATTTLWVLGQAFINIGYVIGLL 378
Cdd:TIGR02615 243 RQKCFYLPEPHNDFIFAIIGEELGLIGGTFIILLFVILLWRGIRIALKAPDLFGTLLAVGITSMIGIQAMINIAVVTGSI 322
                         330       340       350
                  ....*....|....*....|....*....|..
gi 950436382  379 PVTGLQLPLISAGGTSTAATLSLIGIIANAAR 410
Cdd:TIGR02615 323 PVTGVTLPFISYGGSSLTLMMMAVGILLNISR 354
PRK10774 PRK10774
cell division protein FtsW; Provisional
67-394 3.90e-49

cell division protein FtsW; Provisional


Pssm-ID: 182719  Cd Length: 404  Bit Score: 174.20  E-value: 3.90e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382  67 LTTLGLIMVLSASAVRSYDDDGSAWVIFGKQVLWTLVGLIGGYVCLRMSVRFMRRIAFSGFAITIVMLVLVLVpgIGKEA 146
Cdd:PRK10774  45 LAAIGFVMVTSASMPVGQRLANDPFLFAKRDAVYLILAFGLALITLRLPMEFWQRYSATMLLGSIIMLLIVLV--VGSSV 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382 147 NGSRGWFVVAGFSMQPSELAKMAFAIWGAHLLAARRME-RASLREMLIPLvpAAVVALA-LIVAQPDLGQTVSMGIILLG 224
Cdd:PRK10774 123 NGASRWIALGPLRIQPAELTKLSLFCYLANYLVRKVDEvRNNFWGFLKPM--GVMLVLAvLLLAQPDLGTVVVLFVTTLA 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382 225 LLWYAGLPLRVFLSSLAAVVVSAAILAVSAGYRSDRVRSWLNPENDPQDSGYQARQAKFALAQGGIFGDGLGQGVAKWNY 304
Cdd:PRK10774 201 MLFLAGAKLWQFIAIIGMGISAVVLLILAEPYRIRRVTSFWNPWEDPFGSGYQLTQSLMAFGRGELWGQGLGNSVQKLEY 280
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382 305 LPNAHNDFIFAIIGEELGLVGALGLLGLFGLFAYTGMRIASRSAD---PFLRLLTATTTLWVLGQAFINIGYVIGLLPVT 381
Cdd:PRK10774 281 LPEAHTDFIFSIIGEELGYIGVVLALLMVFFVAFRAMSIGRKALEidqRFSGFLACSIGIWFSFQALVNVGAAAGMLPTK 360
                        330
                 ....*....|...
gi 950436382 382 GLQLPLISAGGTS 394
Cdd:PRK10774 361 GLTLPLISYGGSS 373
PRK10794 PRK10794
rod shape-determining protein RodA;
131-411 1.20e-31

rod shape-determining protein RodA;


Pssm-ID: 182737  Cd Length: 370  Bit Score: 125.62  E-value: 1.20e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382 131 IVMLVLVLVPGIGKEANGSRGWFVVAGFSMQPSELAKMAFAiwgahLLAARRMER----ASLREMLIPLVPAAVVALaLI 206
Cdd:PRK10794  81 ICIILLVAVDAFGQISKGAQRWLDLGIVRFQPSEIAKIAVP-----LMVARFINRdvcpPSLKNTAIALVLIFMPTL-LV 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382 207 VAQPDLGQTVSMGIILLGLLWYAGLPLRvfLSSLAAVVVSAAI----LAVSAGYRSDRVRSWLNPENDPQDSGYQARQAK 282
Cdd:PRK10794 155 AAQPDLGTSILVALSGLFVLFLSGLSWR--LIGVAVVLVAAFIpilwFFLMHDYQRQRVMMLLDPESDPLGAGYHIIQSK 232
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382 283 FALAQGGIFGDGLGQGV-AKWNYLPNAHNDFIFAIIGEELGLVGALGLLGLFGLFAYTGMRIASRSADPFLRLLTATTTL 361
Cdd:PRK10794 233 IAIGSGGLRGKGWLHGTqSQLEFLPERHTDFIFAVLAEELGLVGVLILLALYILLIMRGLWIAARAQTTFGRVMAGGLML 312
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 950436382 362 WVLGQAFINIGYVIGLLPVTGLQLPLISAGGTSTAATLSLIGIIANAARH 411
Cdd:PRK10794 313 ILFVYVFVNIGMVSGILPVVGVPLPLVSYGGSALIVLMAGFGIVMSIHTH 362
RodA_shape NF037961
rod shape-determining protein RodA; Proteins of this family are members of the FtsW/RodA/SpoVE ...
59-394 5.33e-27

rod shape-determining protein RodA; Proteins of this family are members of the FtsW/RodA/SpoVE superfamily. It has been reported that RodA proteins play important roles in maintaining cell shape and antibiotic resistance in bacteria.


Pssm-ID: 411566  Cd Length: 415  Bit Score: 113.07  E-value: 5.33e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382  59 LIIAVAALLTTLGLIMVLSAS---AVRSYDDDGSawvIFGKQVLWTLVGLIGGYVCLRMSVRFMRRiaFSGFAITIVMLV 135
Cdd:NF037961   3 ITILLYLLLVGFGWLNIYSAShtgESTSIFDFSQ---IYGKQLIFIGLSFVLIILILAIEAKFYER--FSSIIYIISLLS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382 136 LVLVPGIGKEANGSRGWFVVAGFSMQPSELAKMAFAIWGAHLLAARRME----RASLREMLIPLVPAAvvalaLIVAQPD 211
Cdd:NF037961  78 LLGLFIFGKTINGATSWYAIGGFTLQPSEFAKAATALALAKYLSDIQTDikrfKDQLKAFAIILIPAI-----LILLQPD 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382 212 LGQTV---SMGIIL------LGLLWYAGLPLRVFLSSLA----AVVVSAAILAVSAGYRS-------------------- 258
Cdd:NF037961 153 AGSALvyfAFFFVLyreglpLIYLIIGFILILLFVLTLKfgpiWVLIIAALLIFLYYFLKkkkkppilkiiiillicilf 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382 259 -----------------DRVRSWLNPENDP-------QDSGYQARQAKFALAQGGIFGDGLGQGV-AKWNYLPNAHNDFI 313
Cdd:NF037961 233 sfsvnfvydnvleqhhrDRFSLWLGLEKDPekleqmkKTIGYNTNQSEKAISSGGFTGKGFLEGTrTKGNFVPEQHTDYI 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950436382 314 FAIIGEELGLVGALGLLGLFGLFAYTGMRIASRSADPFLRLLTATTTLWVLGQAFINIGYVIGLLPVTGLQLPLISAGGT 393
Cdd:NF037961 313 FSTVGEEWGFLGSSLVVLLFVLLLLRIIYLAERQKSQFSRVYGYSVASILFIHFFINIGMVIGLIPTIGIPLPFFSYGGS 392

                 .
gi 950436382 394 S 394
Cdd:NF037961 393 G 393
PRK10995 PRK10995
MarC family NAAT transporter;
74-133 4.40e-03

MarC family NAAT transporter;


Pssm-ID: 236814  Cd Length: 221  Bit Score: 38.79  E-value: 4.40e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 950436382  74 MVLS-ASAVRSyDDDGSAWVIFGKQVLWTLVGLIGGYVCLRMSVRFMRRIAFSGF-AITIVM 133
Cdd:PRK10995 137 MIISsASTIAE-GSTFADWVLMVAPPLIFLLVALILWGSLRSSGAIMRLLGKGGIeAISRLM 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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