|
Name |
Accession |
Description |
Interval |
E-value |
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
9-880 |
0e+00 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 1535.38 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 9 YDPQQVESAAQKYWDATRAFEVDETSDKPKYYCLSMLPYPSGALHMGHVRNYTIGDVISRYKRMTGHNVLQPMGWDAFGL 88
Cdd:COG0495 5 YNPKEIEKKWQKYWEENGTFKADEDSSKPKYYVLDMFPYPSGRLHMGHVRNYTIGDVVARYKRMQGYNVLHPMGWDAFGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 89 PAENAAIKNKTAPAAWTYKNIDHMRSQLQSLGYAIDWSREFATCRPDYYVHEQRMFTRLMRKGLAYRRNAVVNWDPVDQT 168
Cdd:COG0495 85 PAENAAIKNGVHPAEWTYENIANMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYEKGLAYRKEAPVNWCPVDQT 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 169 VLANEQVIDGRGWRSGALVEKREIPQWFLRITDYAQELLDGLDELDGWPESVKTMQRNWIGRSEGLEIQFDVRDVDgsal 248
Cdd:COG0495 165 VLANEQVIDGRCWRCGAPVEKKELPQWFLKITDYADELLDDLDKLDGWPEKVKTMQRNWIGRSEGAEVDFPVEGSD---- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 249 DPLRVFTTRPDTVMGVTFVSIAAEHPLALHAA--KNNPELAAMLADLKQGGVSEAELETQEKRGMDTGLRALHPVTGEPV 326
Cdd:COG0495 241 EKITVFTTRPDTLFGATFMVLAPEHPLVKELAtpEQNAAVAAFIEEAKKKSEIERTSETKEKTGVFTGLYAINPLTGEKI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 327 PVWVANFVLMGYGTGAVMAVPGHDQRDNEVANKYGLPIKQVIALKDARTEEErnwdgsrWQDWYSDKSRafeLVNSAEFD 406
Cdd:COG0495 321 PIWIADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIAPEDGDDPDI-------LEEAYTGDGV---LINSGEFD 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 407 GLDFQGAFEALAERFERKAQGQRRVNYRLRDWGVSRQRYWGCPIPVIYCAKCGAVPVPEEQLPVVLPEDVAFSGTG-SPI 485
Cdd:COG0495 391 GLDSEEAKEAIIEWLEEKGLGKRKVNYRLRDWLISRQRYWGEPIPIIHCEDCGVVPVPEDQLPVELPEDVDFDPTGgSPL 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 486 KTDPEWRKTTCPDCGGAAERETDTFDTFMESSWYYARYTSPGARDA-VDK-RGNYWLPVDQYIGGIEHAILHLMYFRFYH 563
Cdd:COG0495 471 ARAPEWVNVTCPKCGGPARRETDTMDTFVDSSWYYLRYTDPHNDEApFDPeAANYWLPVDQYIGGIEHAILHLLYARFFT 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 564 KLLRDARMVDSNEPARNLLCQGMVIaetyyrpnpdgskdwinpadvEVQRDergritgatliadgqPVVVGGTEKMSKSK 643
Cdd:COG0495 551 KVLRDLGLVSFDEPFKRLLTQGMVL---------------------EVGKD---------------GVVIGGIEKMSKSK 594
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 644 NNGVDPQAMVGKYGADTVRLFSMFAAPPEQSLEWNEAGVDGMARFLRRLWAQVQKHAADGAapvLDVAALDANQKALRRK 723
Cdd:COG0495 595 GNVVDPDEIIEKYGADTLRLFEMFAGPPERDLEWSDSGVEGAYRFLNRVWRLVVDEAEALK---LDVADLSEADKELRRA 671
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 724 THETIGKVGDDYGRRHsFNTAIAAVMELMNALAKFEDGSEQGRAVRQEALQAIVLLLNPITPHASHALWQVLGHGETLLe 803
Cdd:COG0495 672 LHKTIKKVTEDIERLR-FNTAIAALMELVNALYKAKDSGEADRAVLREALETLVLLLAPFAPHIAEELWERLGHEGSVA- 749
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 950753960 804 DQPFPQADAGALVRDALTLAVQVNGKLRGTIEVAADAAREQVEALALAEPNAARFMEGLTVRKIIIVPGKIVNIVAA 880
Cdd:COG0495 750 DAPWPEADEAALVEDEVTIVVQVNGKVRGKIEVPADASKEELEAAALADEKVQKFLEGKTIRKVIVVPGKLVNIVVK 826
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
9-880 |
0e+00 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 1219.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 9 YDPQQVESAAQKYWDATRAFEVDETSDKPKYYCLSMLPYPSGALHMGHVRNYTIGDVISRYKRMTGHNVLQPMGWDAFGL 88
Cdd:TIGR00396 1 YNHIEIEEKWQQKWDENKTFKVTDDSSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 89 PAENAAIKNKTAPAAWTYKNIDHMRSQLQSLGYAIDWSREFATCRPDYYVHEQRMFTRLMRKGLAYRRNAVVNWDPVDQT 168
Cdd:TIGR00396 81 PAENAAIKRGIHPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEADVNWCPNDGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 169 VLANEQVI-DGRGWRSGALVEKREIPQWFLRITDYAQELLDGLDELDGWPESVKTMQRNWIGRSEGLEIQFDVRDVDgsa 247
Cdd:TIGR00396 161 VLANEQVDsDGRSWRGDTPVEKKELKQWFLKITAYAEELLNDLEELDHWPESVKEMQRNWIGKSEGVEITFKIADHD--- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 248 lDPLRVFTTRPDTVMGVTFVSIAAEHPLALHAAKNNPELAAMLADLKQGGVSEAELETQEKRGMDTGLRALHPVTGEPVP 327
Cdd:TIGR00396 238 -EKITVFTTRPDTIFGVTYLALAPEHPLVEKAAENNPKVAAFIKKILNKTVAERTKATKEKKGVDTGIKAIHPLTGEKIP 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 328 VWVANFVLMGYGTGAVMAVPGHDQRDNEVANKYGLPIKQVI--ALKDARTEEERNWDGsrwqdwysdksrafELVNSAEF 405
Cdd:TIGR00396 317 IWVANYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVIdpAEKDLSLTAAYTEDG--------------VLVNSGEF 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 406 DGLDFQGAFEALAERFERKAQGQRRVNYRLRDWGVSRQRYWGCPIPVIYCAKCGAVPVPEEQLPVVLPEDVAFSGTG-SP 484
Cdd:TIGR00396 383 NGLNSSEARNAIIDMLEKEGKGKRKVNYRLRDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEDLPVILPEDVVYDGDGgSP 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 485 IKTDPEWRKTTCPDCGGAAERETDTFDTFMESSWYYARYTSPGARD--AVDKRGNYWLPVDQYIGGIEHAILHLMYFRFY 562
Cdd:TIGR00396 463 LSRIPEWVNVTCPSCGKPALRETDTMDTFAGSSWYYLRYLDPKNTDgpFDKEKAEYWLPVDLYIGGIEHAILHLLYARFF 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 563 HKLLRDARMVDSNEPARNLLCQGMVIAETYYrpnPDGSKdwinPADVEVQRDERGritgatLIADGQPVVVGGTEKMSKS 642
Cdd:TIGR00396 543 HKFLRDIGYVNTKEPFKKLINQGMVLGFYYP---PNGKV----PADVLTERDEKG------KDKAGGELVYVGYEKMSKS 609
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 643 KNNGVDPQAMVGKYGADTVRLFSMFAAPPEQSLEWNEAGVDGMARFLRRLWAQVQKHAADGAAPVLDVAALDANQKALRR 722
Cdd:TIGR00396 610 KGNGIDPQEIVESYGADALRLFIMFMGPIAASLEWNESGLEGARRFLDRVWNLVYEITGELDAASLTVTALEEAQKELRR 689
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 723 KTHETIGKVGDDYGRRHSFNTAIAAVMELMNALAKFEDgseqgRAVRQEALQAIVLLLNPITPHASHALWQVLGHGETLL 802
Cdd:TIGR00396 690 DVHKFLKKVTEDLEKRESFNTAISAMMELLNKLYKAKK-----EALMLEYLKGFVTVLSPFAPHLAEELWEKLGSEPFII 764
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 950753960 803 EDQPFPQADAGALVRDALTLAVQVNGKLRGTIEVAADAAREQVEALALAEPNAARFMEGLTVRKIIIVPGKIVNIVAA 880
Cdd:TIGR00396 765 DNAKWPVVDETALVEDKTLIVVQVNGKFRAKITVPKDADEEQVEELAKQDPEVKKYLENKTIKKVIYVPGKLVNFVIK 842
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
2-879 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 844.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 2 TSVEPNVYDPQQVESAAQKYWDATRAFEVDETSD--KPKYYCLSMLPYPSGA-LHMGHVRNYTIGDVISRYKRMTGHNVL 78
Cdd:PLN02563 73 TPAAKRAYPFHEIEPKWQRYWEENRTFRTPDDVDtsKPKFYVLDMFPYPSGAgLHVGHPEGYTATDILARYKRMQGYNVL 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 79 QPMGWDAFGLPAENAAIKNKTAPAAWTYKNIDHMRSQLQSLGYAIDWSREFATCRPDYYVHEQRMFTRLMRKGLAYRRNA 158
Cdd:PLN02563 153 HPMGWDAFGLPAEQYAIETGTHPKITTLKNIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEV 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 159 VVNWDPVDQTVLANEQVIDGRGWRSGALVEKREIPQWFLRITDYAQELLDGLDELDgWPESVKTMQRNWIGRSEGLEIQF 238
Cdd:PLN02563 233 PVNWCPALGTVLANEEVVDGLSERGGHPVIRKPMRQWMLKITAYADRLLEDLDDLD-WPESIKEMQRNWIGRSEGAELDF 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 239 DVRDVDGSALD-PLRVFTTRPDTVMGVTFVSIAAEHPLAlhAAKNNPELAAMLADLKQGGVSEAELE----TQEKRGMDT 313
Cdd:PLN02563 312 SVLDGEGKERDeKITVYTTRPDTLFGATYLVVAPEHPLL--SSLTTAEQKEAVEEYVDAASRKSDLErtelQKEKTGVFT 389
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 314 GLRALHPVTGEPVPVWVANFVLMGYGTGAVMAVPGHDQRDNEVANKYGLPIKQVIAlkdarteeerNWDGSRWqdwysDK 393
Cdd:PLN02563 390 GSYAINPATGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVK----------PADGNED-----DA 454
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 394 SRAFE----LVNSAE----FDGLDFQGAFEALAERFERKAQGQRRVNYRLRDWGVSRQRYWGCPIPVIYCAKCG-AVPVP 464
Cdd:PLN02563 455 EKAYTgegvIVNSSSsgldINGLSSKEAAKKVIEWLEETGNGKKKVNYKLRDWLFARQRYWGEPIPVVFLEDSGePVPVP 534
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 465 EEQLPVVLPEDVAFSGTGS---PIKTDPEWRKTTCPDCGGAAERETDTFDTFMESSWYYARYTSPGARDA-VDK-RGNYW 539
Cdd:PLN02563 535 ESDLPLTLPELDDFTPTGTgepPLAKAVSWVNTVDPSSGKPARRETNTMPQWAGSCWYYLRFMDPKNSNAlVDKeKEKYW 614
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 540 LPVDQYIGGIEHAILHLMYFRFYHKLLRDARMVDSNEPARNLLCQGMVIAETYYRPNPDGSKDWINpADVEVQRDERG-- 617
Cdd:PLN02563 615 MPVDLYVGGAEHAVLHLLYARFWHKVLYDIGVVSTKEPFQCLVNQGMILGEVEYTAFKDSDGEYVS-ADTADRLGELQqe 693
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 618 RITGATLIADGQPVVVGGTE---------KMSKSKNNGVDPQAMVGKYGADTVRLFSMFAAPPEQSLEWNEAGVDGMARF 688
Cdd:PLN02563 694 KIPEEKVIKSGDSFVLKDDPsirliarahKMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWSTSGVEGVHRF 773
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 689 LRRLWAQVQKHAA-DGAAPVLDVAALDANQKALRRKTHETIGKVGDDYgRRHSFNTAIAAVMELMNALAKFEDgseqgra 767
Cdd:PLN02563 774 LGRTWRLVVGAPLpDGSFRDGTVVTDEEPSLEQLRLLHKCIAKVTEEI-ESTRFNTAISAMMEFTNAAYKWDK------- 845
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 768 VRQEALQAIVLLLNPITPHASHALWQVLGHgETLLEDQPFPQADAGALVRDALTLAVQVNGKLRGTIEVAADAAREQVEA 847
Cdd:PLN02563 846 VPREAIEPFVLLLSPYAPHLAEELWFRLGH-SNSLAYEPWPEANPSYLVDDTVVLPVQINGKTRGTIEVEEGCSEDDAFA 924
|
890 900 910
....*....|....*....|....*....|..
gi 950753960 848 LALAEPNAARFMEGLTVRKIIIVPGKIVNIVA 879
Cdd:PLN02563 925 LASQDEKLSKYLDGKEIKKRIYVPGKILNVIL 956
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
38-677 |
1.49e-103 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 323.43 E-value: 1.49e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 38 KYYCLSMLPYPSGALHMGHVRNYTIGDVISRYKRMTGHNVLQPMGWDAFGLPAENAAIKNKTAPAAWTYKNIDHMRSQLQ 117
Cdd:cd00812 1 KFYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDWTEYNIKKMKEQLK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 118 SLGYAIDWSREFATCRPDYYVHEQRMFTRLMRKGLAYRRNAVVNWDpvdqtvlaneqvidgrgwrsgalvekREIPQWFL 197
Cdd:cd00812 81 RMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC--------------------------KLLDQWFL 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 198 RITDYAqelldgldeldgWPESVKTMqrnwigrsegleiqfdvrdvdgsaLDPLRVFttrPDTVmgvtfvsiaaehplal 277
Cdd:cd00812 135 KYSETE------------WKEKLLKD------------------------LEKLDGW---PEEV---------------- 159
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 278 haaknnpelaamladlkqggvseaeletqekrgmdtglralhpvtgepvpvwvanfvlmgygtgavmavpghdqrdneva 357
Cdd:cd00812 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 358 nkyglpikqvialkdarteeernwdgsrwqdwysdksrafelvnsaefdgldfqgafealaerfeRKAQgqrrvnyrlRD 437
Cdd:cd00812 160 -----------------------------------------------------------------RAMQ---------EN 165
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 438 W-GVSRQRYWGCPIPViycakcgavpvpeeqlpvvlpedvafsgtgspiktdpewrkttcpdcggaaereTDTFDTFMES 516
Cdd:cd00812 166 WiGCSRQRYWGTPIPW------------------------------------------------------TDTMESLSDS 191
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 517 SWYYARYTSP--------GARDAVDKRGNYWLPVDQYIGGIEHAILHLMYFRFYHKLLRDARMVdSNEPARNLLCQGMvi 588
Cdd:cd00812 192 TWYYARYTDAhnleqpyeGDLEFDREEFEYWYPVDIYIGGKEHAPNHLLYSRFNHKALFDEGLV-TDEPPKGLIVQGM-- 268
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 589 aetyyrpnpdgskdwinpadvevqrdergritgatliadgqpvVVGGTEKMSKSKNNGVDPQAMVGKYGADTVRLFSMFA 668
Cdd:cd00812 269 -------------------------------------------VLLEGEKMSKSKGNVVTPDEAIKKYGADAARLYILFA 305
|
....*....
gi 950753960 669 APPEQSLEW 677
Cdd:cd00812 306 APPDADFDW 314
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
225-422 |
5.11e-95 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 295.99 E-value: 5.11e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 225 RNWIGRSEGLEIQFDVRDVDGSaldpLRVFTTRPDTVMGVTFVSIAAEHPLALHAAKNNPELAAMLADLKQGGVSEAELE 304
Cdd:pfam13603 1 RNWIGRSEGAEITFPVEGTDEK----IEVFTTRPDTLMGVTFVALAPEHPLVEKLAEKNPEVAAFIEECKNTSEIERTSE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 305 TQEKRGMDTGLRALHPVTGEPVPVWVANFVLMGYGTGAVMAVPGHDQRDNEVANKYGLPIKQVIALKDArteeerNWDGS 384
Cdd:pfam13603 77 TKEKEGVFTGLYAIHPITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIQPEDG------DLDLD 150
|
170 180 190
....*....|....*....|....*....|....*...
gi 950753960 385 RWQDWYSDKSRafeLVNSAEFDGLDFQGAFEALAERFE 422
Cdd:pfam13603 151 IMTEAYTEEGI---LVNSGEFDGLDSEEAKEAIIKKLE 185
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
5-812 |
1.39e-86 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 294.66 E-value: 1.39e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 5 EPNVYDPQQVESAAQKYWDATRAFEVDETSDKPKYYCLSMLPYPSGALHMGHVRNYTIGDVISRYKRMTGHNVLQPMGWD 84
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKPDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 85 AFGLPAEN-----AAIKNKTAPAA-----------WTYKNIDHMRSQLQSLGYAIDWSREFATCRPDYYVHEQRMFTRLM 148
Cdd:TIGR00422 81 HAGIATQVkvekkLGAEGKTKHDLgreefrekiweWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 149 RKGLAYRRNAVVNWDPVDQTVLANEQVIdgrgwrsgalVEKREIPQWFLRitdyaqelldgldeldgWPesvktmqrnwi 228
Cdd:TIGR00422 161 EKGLIYRGEYLVNWDPKLNTAISDIEVE----------YKEVKGKLYYIR-----------------YP----------- 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 229 grsegleiqfdvrdVDGSALDPLRVFTTRPDTVMGVTFVsiaAEHPlalhaakNNPELAAMLadlkqggvseaeletqek 308
Cdd:TIGR00422 203 --------------LANGSKDYLVVATTRPETMFGDTAV---AVHP-------EDERYKHLI------------------ 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 309 rgmdtGLRALHPVTGEPVPVWVANFVLMGYGTGAVMAVPGHDQRDNEVANKYGLPIKQVIALKDARTEEERNWDG-SRWQ 387
Cdd:TIGR00422 241 -----GKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDEDGLLNENAGKYQGlTRFE 315
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 388 -----------------------------------------DWYSD-KSRAFELVNSAEFDGLDFqgafeaLAERFErka 425
Cdd:TIGR00422 316 arkkivedlkeegllvkiephthnvgtcwrsgtvvepllskQWFVKvEKLADKALEAAEEGEIKF------VPKRME--- 386
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 426 qgqRRVNY---RLRDWGVSRQRYWGCPIPVIYCAKCGAVPVPEEQLPVVlpedvafsgtgSPIKTDPEWRkttcpdcgga 502
Cdd:TIGR00422 387 ---KRYLNwlrNIKDWCISRQLIWGHRIPVWYCKECGEVYVAKEEPLPD-----------DKTNTGPSVE---------- 442
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 503 AERETDTFDTFMeSSWYYARYTSPGARDAVDKRGNYwlPVDQYIGGieHAILhlmyfRFYHkllrdARMVDSNE------ 576
Cdd:TIGR00422 443 LEQDTDVLDTWF-SSSLWPFSTLGWPDETKDLKKFY--PTDLLVTG--YDII-----FFWV-----ARMIFRSLaltgqv 507
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 577 PARNLLCQGMViaetyyrpnpdgskdwinpadvevqRDERGRitgatliadgqpvvvggteKMSKSKNNGVDPQAMVGKY 656
Cdd:TIGR00422 508 PFKEVYIHGLV-------------------------RDEQGR-------------------KMSKSLGNVIDPLDVIEKY 543
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 657 GADTVRLFSMFAAPPEQSLEWNEAGVDGMARFLRRLWaQVQKHAADGAAPVLDVAALDANQKALRR----KTHETIGKVG 732
Cdd:TIGR00422 544 GADALRFTLASLVTPGDDINFDWKRVESARNFLNKLW-NASRFVLMNLSDDLELSGGEEKLSLADRwilsKLNRTIKEVR 622
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 733 ---DDYGrrhsFNTAIAAVMELM--------NALAKFEDGS---EQGRAVRQEA---LQAIVLLLNPITPHASHALWQVL 795
Cdd:TIGR00422 623 kalDKYR----FAEAAKALYEFIwndfcdwyIELVKYRLYNgneAEKKAARDTLyyvLDKALRLLHPFMPFITEEIWQHF 698
|
890
....*....|....*..
gi 950753960 796 GHGETLLEDQPFPQADA 812
Cdd:TIGR00422 699 KEGADSIMLQSYPVVDA 715
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
6-849 |
6.44e-75 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 261.28 E-value: 6.44e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 6 PNVYDPQQVESAAQKYWDATRAFEVDETSDKPKYYCLSMLPYPSGALHMGHVRNYTIGDVISRYKRMTGHNVLQPMGWDA 85
Cdd:PRK13208 7 PKKYDPEELEEKWQKIWEEEGTYKFDPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWDD 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 86 FGLPAENAAIKNKTAPAA-------------WTYKNIDHMRSQLQSLGYAIDWSREFATCRPDYYVHEQRMFTRLMRKGL 152
Cdd:PRK13208 87 NGLPTERKVEKYYGIRKDdisreefielcreLTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDLYKKGL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 153 AYRRNAVVNWDPVDQTVLANeqvidgrgwrsgALVEKREIPQWFLRITdyaqelldgldeldgwpesvktmqrnwigrse 232
Cdd:PRK13208 167 IYRAEAPVLWCPRCETAIAQ------------AEVEYREREGKLNYIK-------------------------------- 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 233 gleiqFDVrdVDGsalDPLRVFTTRPDtVMGVTfVSIAAehplalhaaknNPElaamladlkqggvseaeletqekrgmD 312
Cdd:PRK13208 203 -----FPV--EDG---EEIEIATTRPE-LLPAC-VAVVV-----------HPD--------------------------D 233
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 313 T------GLRALHPVTGEPVPVWVANFVLMGYGTGAVMAVPGHDQRDNEVANKYGLPIKQVI----------------AL 370
Cdd:PRK13208 234 ErykhlvGKTAIVPLFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIIIdedgrmteaagklaglTI 313
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 371 KDARTE-----EERNWDGSRWQ-------DWYSDKSraFELVNSAEF--DGLDFQGAFEALAERFERKAQgqrrvNYRLR 436
Cdd:PRK13208 314 EEARKKivedlKSGGLLGKQEPikhnvkfCERCDTP--LEILVTRQWfiKVLDLKEELLERGKEINWYPE-----HMRVR 386
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 437 ----------DWGVSRQRYWGCPIPVIYCAKCGAVPVP-EEQLPVVlpedvafsgtgsPIKTDPEWRKttCPDCG-GAAE 504
Cdd:PRK13208 387 lenwieglnwDWCISRQRYFGTPIPVWYCKDCGHPILPdEEDLPVD------------PTKDEPPGYK--CPQCGsPGFE 452
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 505 RETDTFDTFMESSwyyaryTSPgardavdkrgnywlpvdQYIGGIEH-AILHLMYFRF--------------YHKLLRdA 569
Cdd:PRK13208 453 GETDVMDTWATSS------ITP-----------------LIVTGWERdEDLFEKVFPMdlrpqghdiirtwlFYTILR-A 508
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 570 RMVDSNEPARNLLCQGMVIAetyyrpnPDGskdwinpadvevqrdergritgatliadgqpvvvggtEKMSKSKNNGVDP 649
Cdd:PRK13208 509 YLLTGKLPWKNIMISGMVLD-------PDG-------------------------------------KKMSKSKGNVVTP 544
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 650 QAMVGKYGADTVRLFSMfAAPPEQSLEWNEAGVDGMARFLRRLW------AQVQKHAADGAAPVLdvAALDanqKALRRK 723
Cdd:PRK13208 545 EELLEKYGADAVRYWAA-SARLGSDTPFDEKQVKIGRRLLTKLWnasrfvLHFSADPEPDKAEVL--EPLD---RWILAK 618
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 724 THETIGKVGDDYgRRHSFNTAIAAVM------------ELMNALAKFEDGSEQGRAVR---QEALQAIVLLLNPITPHAS 788
Cdd:PRK13208 619 LAKVVEKATEAL-ENYDFAKALEEIEsffwhvfcddylELVKSRAYGEDEEEEQKSARytlYTVLDTLLRLLAPFLPFIT 697
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 950753960 789 HALWQVLGHGETLLEDQPFPQADAGAL-VRDALTLAVQVNGKLRG--------------TIEVAADAAREQVEALA 849
Cdd:PRK13208 698 EEVWSWLYGGSVHRASWPEPDEELIDEeDEELGELAKEILSAVRKykseaglslnaplkKVEVYGPADLELLEAAE 773
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
19-677 |
3.10e-60 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 215.74 E-value: 3.10e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 19 QKYWDATRAFEVDETSDKPK-YYCLSM-LPYPSGALHMGHVRNYTIGDVISRYKRMTGHNVLQPMGWDAFGLPAENA--- 93
Cdd:pfam00133 3 YEFWDEQGYFKPELEKRKGKpSFTIHDgPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVvek 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 94 --AIKNKTAPA------------AWTYKNIDHMRSQLQSLGYAIDWSREFATCRPDYYVHEQRMFTRLMRKGLAYRRNAV 159
Cdd:pfam00133 83 klGIKEKKTRHkygreefrekcrEWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGKKL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 160 VNWDPVDQTVLANeqvidgrgwrsgALVEKREI--PQWFLRItdyaqelldgldeldgwpesvktmqrnwigrsegleiq 237
Cdd:pfam00133 163 VNWSPALNTALSN------------LEVEYKDVkgPSIHVAF-------------------------------------- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 238 fdvrDVDGSALDPLRVFTTRPDTVMGVTFVSIAAEhplaLHAAKNNPELAAMLADLKQGGVSEAELETQEK-RGMD-TGL 315
Cdd:pfam00133 193 ----PLADDEGASLVIWTTTPWTLPGNTAVAVNPE----FDYVITGEGYILAEALLKSLYKKGTDKKILEDfRGKElEGK 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 316 RALHPVTGEPVPVWVANFVLMGYGTGAVMAVPGHDQRDNEVANKYGLPIKQVIALKDARTEEERNWDGSRWQD------- 388
Cdd:pfam00133 265 EAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPVDDDGTFTEEAPDFQGVYRFDarkkive 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 389 ---------------------WYSDKSRAFELVNS--AEFDGLDFQgAFEALAERFERKAQGQRRVNYRL---RDWGVSR 442
Cdd:pfam00133 345 lltekglllkiepfthsypfcWRSGTPIIPRATPQwfVRMDELADQ-ALEAVEKVQFVPKSGEKRYFNWLaniQDWCISR 423
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 443 QRYWGCPIPVIYCAKCGAVPVPEEqlpvvLPEDVAFSGTGSPIKTDPEWR-KTTCPDCGGAAERETDTFDTFMES-SWYY 520
Cdd:pfam00133 424 QRWWGHPIPAWVSKDTEEVVCRGE-----LFELVAGRFEEEGSIKWLHREaKDKLGYGKGTLEQDEDVLDTWFSSgSWPF 498
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 521 ARYTSPgARDAVDKRGNYwlPVDQYIGGIEhailhLMYFRFYHKLLRDARMVDSnEPARNLLCQGMViaetyyrpnpdgs 600
Cdd:pfam00133 499 STLGWP-FVNTEEFKKFF--PADMLLEGSD-----QTRGWFYRMIMLSTALTGS-VPFKNVLVHGLV------------- 556
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 950753960 601 kdwinpadvevqRDERGRitgatliadgqpvvvggteKMSKSKNNGVDPQAMVGKYGADTVRLFsMFAAPPEQSLEW 677
Cdd:pfam00133 557 ------------RDEQGR-------------------KMSKSLGNVIDPLDVIDKYGADALRLW-LANSDYGRDINL 601
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
5-845 |
3.14e-60 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 220.71 E-value: 3.14e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 5 EPNVYDPQQVESAAQKYWDATRAFE--VDETSDKPKYYCLSMLPYPSGALHMGHVRNYTIGDVISRYKRMTGHNVLQPMG 82
Cdd:TIGR00392 2 FPMRGNLSKREEKILAFWQENDIFEkvKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 83 WDAFGLPAENAAIKNKTAPA-------------------AWtyKNIDHMRSQLQSLGYAIDWSREFATCRPDYYVHEQRM 143
Cdd:TIGR00392 82 WDTHGLPIEHKVEKKLGISGkkeissleieefrekcrefAL--KQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 144 FTRLMRKGLAYRRNAVVNWDPVDQTVLANEQVidgrgwrsgalvekreipqwflritdyaqelldgldELDGWPESVKtm 223
Cdd:TIGR00392 160 FKEAHEKGLLYRGLKPVYWSPRCRTALAEAEV------------------------------------EYKENYKDVK-- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 224 qrnwigrSEGLEIQFDVRDVD----GSALDPLRVFTTRPDTVMGVTFVSIAAEHPLALHAAKNNPELAAMLADL-----K 294
Cdd:TIGR00392 202 -------DPSIYVKFPVKKDKktylKVKLSSLLIWTTTPWTLPSNLAIAVHPDFEYALVQDNTKVEYFILAKKLveklyN 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 295 QGGVSEAELETQEKRGMDtGLRALHPVTGEPVPVWVANFVLMGY-------GTGAVMAVPGHDQRDNEVANKYGLPIKQV 367
Cdd:TIGR00392 275 KAGSDYEIIKTFKGSDLE-GLEYEHPLYDFVSQLKEGAPVVIGGdhvttedGTGIVHTAPGHGEEDYEIGKKYGLEVLSP 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 368 IALKDARTEEERNWDGSRWQDwySDKSraFELVNSAEFDGLDFQGAFeALAERFERK--------------AQGQ----- 428
Cdd:TIGR00392 354 VDEKGVYTEGVNDFQGRFVKD--ADKD--IIKANKIIIEQLKDKGLL-LKAEKITHSyphcwrtktpviyrATEQwfikt 428
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 429 -----------RRVNY-------RL-------RDWGVSRQRYWGCPIPVIYCAKCGAVPVPE-----EQLPVVLPEDVAF 478
Cdd:TIGR00392 429 kdikdqmleqiKKVNWvpewgegRFgnwlenrPDWCISRQRYWGIPIPIWYCEDTGEPIVVGsieelIELIELKGIDAWF 508
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 479 SGTGSPIKTDpewrKTTCPDCGGAAERETDTFDTFMES-SWYYArytSPGARDAVDKRGNYWlPVDQYIGGIEHailhlm 557
Cdd:TIGR00392 509 EDLHRDFLDK----ITLKSGDGGEYRRVPDVLDVWFDSgSMPYA---SIHYPFENEKFKEVF-PADFILEGSDQ------ 574
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 558 yFR--FYHKLLRdARMVDSNEPARNLLCQGMVIaetyyrpnpdgskdwinpadvevqrDERGRitgatliadgqpvvvgg 635
Cdd:TIGR00392 575 -TRgwFYSSLAI-GTALFGQAPYKNVITHGFTL-------------------------DEKGR----------------- 610
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 636 teKMSKSKNNGVDPQAMVGKYGADTVRLFsMFAAPPEQSLEWNEAGVDGMARFLRRLWAQVQKHAA-----------DGA 704
Cdd:TIGR00392 611 --KMSKSLGNVVDPLKVINKYGADILRLY-VASSDPWEDLRFSDEILKQVVEKYRKIRWNTYRFLLtyanldkfdplFNS 687
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 705 APVLDVAALD----ANQKALRRKTHETIGKvgddygrrHSFNTAIAAVME-LMNALAKF-----------EDGSEQGRAV 768
Cdd:TIGR00392 688 VAVEKFPEEDrwilSRLNSLVEEVNEALEK--------YNFHKVLRALQDfIVEELSNWyiriirdrlycEAKDNDKRAA 759
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 769 RQ---EALQAIVLLLNPITPHASHALWQVL--GHGETLLEDQPFPQADAGALVRdALTLAVQVNGKlrgtIEVAADAARE 843
Cdd:TIGR00392 760 QTtlyYALLTLVRLLAPFLPHTAEEIYQNLpgGEEEESVHLNLWPEVDEEFIDE-ALEANMAIVRE----IVEAFLALRD 834
|
..
gi 950753960 844 QV 845
Cdd:TIGR00392 835 AA 836
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
9-812 |
1.64e-57 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 213.40 E-value: 1.64e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 9 YDPQQVESAAQKYWDATRAFE--VDETSDKPKYYclsmL----PYPSGALHMGHVRNYTIGDVISRYKRMTGHNVL-QPm 81
Cdd:COG0060 16 ANLPKREPEILKFWEENDIYEksREARAGRPKFV----LhdgpPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPyVP- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 82 GWDAFGLPAENAAIKN--KTAPA----------------AWTYknIDHMRSQLQSLGYAIDWSREFATCRPDYYVHEQRM 143
Cdd:COG0060 91 GWDCHGLPIELKVEKElgIKKKDiekvgiaefrekcreyALKY--VDEQREDFKRLGVWGDWDNPYLTMDPEYEESIWWA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 144 FTRLMRKGLAYRRNAVVNWDPVDQTVLANeqvidgrgwrsgALVEKREipqwflrITDYAqelLDgldeldgwpesVKtm 223
Cdd:COG0060 169 LKKLYEKGLLYKGLKPVPWCPRCGTALAE------------AEVEYKD-------VTSPS---IY-----------VK-- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 224 qrnwigrsegleiqFDVRDVDGSALDP---LRVFTTRPDTVMGVTFVSIAAEHPLALhAAKNNPE---LAAMLAD--LKQ 295
Cdd:COG0060 214 --------------FPVKDEKALLLLEdayLVIWTTTPWTLPANLAVAVHPDIDYVL-VEVTGGErliLAEALVEavLKE 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 296 GGVSEAELEtQEKRGMD-TGLRALHP-----VTGEPVPVWVANFVLMGYGTGAV-MAvPGHDQRDNEVANKYGLPIKQVI 368
Cdd:COG0060 279 LGIEDYEVL-ATFKGAElEGLRYEHPfyyvvGYDRAHPVILGDYVTTEDGTGIVhTA-PGHGEDDFEVGKKYGLPVLNPV 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 369 alkDAR---TEEERNWDGSRWQD----------------------------WYSD------------------KSRAFEL 399
Cdd:COG0060 357 ---DDDgrfTEEAPLFAGLFVKDanpaiiedlkergallarekithsyphcWRCKtpliyratpqwfismdklRDRALEA 433
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 400 VNSAEFD---GldfQGAFEA-LAERferkaqgqrrvnyrlRDWGVSRQRYWGCPIPVIYCAKCGAVPVPEEqlpVV--LP 473
Cdd:COG0060 434 IEKVNWIpewG---EGRFGNmLENR---------------PDWCISRQRYWGVPIPIWVCEDCGELHRTEE---VIgsVA 492
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 474 EDVAFSGTGSPIKTDPE--W--RKTTCPDCGGAAERETDTFDTFMES--SWYyarytspgardAV-DKRGNYWLPVDQYI 546
Cdd:COG0060 493 ELLEEEGADAWFELDLHrpFldETLKCPKCGGTMRRVPDVLDVWFDSgsMHF-----------AVlENREELHFPADFYL 561
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 547 GGI-EHailhlmyfR--FYHkLLRDARMVDSNEPARNLLCQGMVIaetyyrpnpdgskdwinpadvevqrDERGRitgat 623
Cdd:COG0060 562 EGSdQT--------RgwFYS-SLLTSTALFGRAPYKNVLTHGFVL-------------------------DEDGR----- 602
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 624 liadgqpvvvggteKMSKSKNNGVDPQAMVGKYGADTVRLFsMFAAPPEQSLEWNEAGVDGMARFLRRLW-------AQV 696
Cdd:COG0060 603 --------------KMSKSLGNVVDPQEVIDKYGADILRLW-VASSDYWGDLRFSDEILKEVRDVYRRLRntyrfllANL 667
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 697 -----QKHA-ADGAAPVLDVAALDanqkalrrKTHETIGKVGDDYgRRHSFNTAIAAVMELMN-------------ALAK 757
Cdd:COG0060 668 ddfdpAEDAvPYEDLPELDRWILS--------RLNELIKEVTEAY-DNYDFHRAYRALHNFCVedlsnwyldiskdRLYT 738
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 950753960 758 FEDGSEQGRAVRQ---EALQAIVLLLNPITPHASHALWQVLGHGET---LLEDqpFPQADA 812
Cdd:COG0060 739 EAADSLDRRAAQTtlyEVLETLVRLLAPILPFTAEEIWQNLPGEAEesvHLAD--WPEVDE 797
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
46-673 |
2.03e-52 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 187.84 E-value: 2.03e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 46 PYPSGALHMGHVRNYTIGDVISRYKRMTGHNVLQPMGWDAFGLPAEN-----AAIKNKTAPAA-----------WTYKNI 109
Cdd:cd00817 10 PNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVvvekkLGIEGKTRHDLgreeflekcweWKEESG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 110 DHMRSQLQSLGYAIDWSREFATCRPDYYVHEQRMFTRLMRKGLAYRRNAVVNWDPVDQTVLANEQVidgrGWRSGALVEK 189
Cdd:cd00817 90 GKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV----CSRSGDVIEP 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 190 REIPQWFLRITDYAQELLDGLDELDgwpesvktmqrnwigrsegleIQFdvrdvdgsaldplrvfttrpdtvmgvtfvsi 269
Cdd:cd00817 166 LLKPQWFVKVKDLAKKALEAVKEGD---------------------IKF------------------------------- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 270 aaehplalhaaknnpelaamladlkqggvseaeletqekrgmdtglralhpvtgepvpvwvanfvlmgygtgavmaVPGH 349
Cdd:cd00817 194 ----------------------------------------------------------------------------VPER 197
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 350 DQRdnevankyglpikqvialkdarteeernwdgsRWQDWYSDksrafelvnsaefdgldfqgafealaerferkaqgqr 429
Cdd:cd00817 198 MEK--------------------------------RYENWLEN------------------------------------- 208
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 430 rvnyrLRDWGVSRQRYWGCPIPVIYCAKCGAVPV-PEEQLPVvlpedvafsgtgspiktdPEWRKTTCPDCGGAA-ERET 507
Cdd:cd00817 209 -----IRDWCISRQLWWGHRIPAWYCKDGGHWVVaREEDEAI------------------DKAAPEACVPCGGEElKQDE 265
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 508 DTFDTFMeSSWYYARYTSPGARDAVDKRGNYwlPVDQYIGGieHAILhlmyfRFYHkllrdARMV------DSNEPARNL 581
Cdd:cd00817 266 DVLDTWF-SSSLWPFSTLGWPEETKDLKKFY--PTSLLVTG--HDII-----FFWV-----ARMImrglklTGKLPFKEV 330
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 582 LCQGMViaetyyrpnpdgskdwinpadvevqRDERGRitgatliadgqpvvvggteKMSKSKNNGVDPQAMVGKYGADTV 661
Cdd:cd00817 331 YLHGLV-------------------------RDEDGR-------------------KMSKSLGNVIDPLDVIDGYGADAL 366
|
650
....*....|..
gi 950753960 662 RLFSMFAAPPEQ 673
Cdd:cd00817 367 RFTLASAATQGR 378
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
52-835 |
4.45e-49 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 187.77 E-value: 4.45e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 52 LHMGHVRNYTIGDVISRYKRMTGHNVLQPMGWDAFGLP----AEnaAIKNKTAPAAWTYKNI------------------ 109
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPilgiAE--RIARGDPETIELYKSLygipeeelekfkdpeyiv 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 110 ----DHMRSQLQSLGYAIDWSREFATCRPDY--YVHEQrmFTRLMRKGLAYRRNAVVNWDPVDQTVLANEQVIDGrgwrs 183
Cdd:PRK12300 79 eyfsEEAKEDMKRIGYSIDWRREFTTTDPEYskFIEWQ--FRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDG----- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 184 galvEKREIPQWFLritdyaqelldgldeldgwpesvktmqrnwigrsegleIQFdvRDVDGSALdPlrVFTTRPDTVMG 263
Cdd:PRK12300 152 ----EEPEIVEYTL--------------------------------------IKF--EESEDLIL-P--AATLRPETIFG 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 264 VTFVSIaaehplalhaaknNPELAAMLADLKqGG---VSEA---ELETQ--------EKRGMD-TGLRALHPVTGEPVPV 328
Cdd:PRK12300 185 VTNLWV-------------NPDATYVKAEVD-GEkwiVSKEaaeKLSFQdrdveiieEIKGSElIGKKVKNPVTGKEVPI 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 329 WVANFVLMGYGTGAVMAVPGH---------DQRDNEVANKYGLPIKqVIALKD-----ARTEEER----NWDGSRWQDwy 390
Cdd:PRK12300 251 LPADFVDPDNGTGVVMSVPAHapydyvalrDLKKNKELLDVIEPIP-LIEVEGygefpAKEVVEKlgikSQEDPELEE-- 327
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 391 sdksrAFELVNSAEF-------DGLDFQG-----AFEALAERFERKAQG-------QRRV-------------------- 431
Cdd:PRK12300 328 -----ATKEVYRAEFhkgvlkeNTGEYAGkpvreAREKITKDLIEKGIAdimyefsNRPVycrcgtecvvkvvkdqwfid 402
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 432 ----------------------NYR---------LRDWGVSRQRYWGCPIP-------------VIYCA------KCGAV 461
Cdd:PRK12300 403 ysdpewkelahkaldnmeiipeEYRkefentidwLKDRACARRRGLGTRLPwdeewiieslsdsTIYMAyytiahKIREY 482
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 462 PVPEEQLPvvlPE--DVAFSGTGSPiktdpewrkttcpdcgGAAERETDTFDTFMEsswyyarytspGARDAVdkrgNYW 539
Cdd:PRK12300 483 GIKPEQLT---PEffDYVFLGKGDP----------------EEVSKKTGIPKEILE-----------EMREEF----LYW 528
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 540 LPVDQYIGGIEHAILHLMYFRFYHKLLRDarmvdsnepaRNLLCQGMVIAETyyrpnpdgskdwinpadvevqrdergri 619
Cdd:PRK12300 529 YPVDWRHSGKDLIPNHLTFFIFNHVAIFP----------EEKWPRGIVVNGF---------------------------- 570
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 620 tgatliadgqpVVVGGtEKMSKSKNNGVDPQAMVGKYGADTVRLFSMFAAPPEQSLEWNEAGVDGMARFLRRLWAQVQKH 699
Cdd:PRK12300 571 -----------VLLEG-KKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSAELLQDADWREKEVESVRRQLERFYELAKEL 638
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 700 AADGAAPVLDvaALDanqKALRRKTHETIGKVGDDYgrrHSFNTAIAAVM---ELMNALAKFED-GSEQGRAVRQEALQA 775
Cdd:PRK12300 639 IEIGGEEELR--FID---KWLLSRLNRIIKETTEAM---ESFQTRDAVQEafyELLNDLRWYLRrVGEANNKVLREVLEI 710
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 776 IVLLLNPITPHASHALWQVLGHgETLLEDQPFPQADAgALVRDALTLAVQVngkLRGTIE 835
Cdd:PRK12300 711 WIRLLAPFTPHLAEELWHKLGG-EGFVSLEKWPEPDE-SKIDEEAELAEEY---VKRLIE 765
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
677-795 |
1.65e-44 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 156.23 E-value: 1.65e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 677 WNEAGVDGMARFLRRLWAQVQKHAADGAAPVLDvAALDANQKALRRKTHETIGKVGDDYGRRHsFNTAIAAVMELMNALA 756
Cdd:cd07958 1 WSDSGVEGAYRFLNRVWRLVTELAEALAAPAAA-AELSEEDKELRRKLHKTIKKVTEDIERLR-FNTAIAALMELVNALY 78
|
90 100 110
....*....|....*....|....*....|....*....
gi 950753960 757 KFEDGSEQGRAVRQEALQAIVLLLNPITPHASHALWQVL 795
Cdd:cd07958 79 KYKKKDAQHAAVLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
1-812 |
2.95e-44 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 172.60 E-value: 2.95e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 1 MTSVEPNVYDPQQVESAAQKYWDATRAFEVDETSDKPkyYCLsMLPYP--SGALHMGHVRNYTIGDVISRYKRMTGHNVL 78
Cdd:PRK05729 1 MMMELPKTYDPKEVEAKWYQKWEEKGYFKPDDNSKKP--FSI-VIPPPnvTGSLHMGHALNNTLQDILIRYKRMQGYNTL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 79 -QP--------------------------MGWDAFglpaenaaIKnktapAAWTYKNI--DHMRSQLQSLGYAIDWSREF 129
Cdd:PRK05729 78 wLPgtdhagiatqmvverqlaaegksrhdLGREKF--------LE-----KVWEWKEEsgGTITNQLRRLGASCDWSRER 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 130 ATCRPDYY--VHEqrMFTRLMRKGLAYRRNAVVNWDPVDQTVLANEQvidgrgwrsgalVEKREIPQ--WFLRitdYAqe 205
Cdd:PRK05729 145 FTMDEGLSkaVRE--VFVRLYEKGLIYRGKRLVNWDPKLQTALSDLE------------VEYKEVKGklWHIR---YP-- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 206 LLDGldeldgwpesvktmqrnwigrSEGLEIqfdvrdvdgsAldplrvfTTRPDTVMGVTFVSIaaehplalhaaknNPE 285
Cdd:PRK05729 206 LADG---------------------SDYLVV----------A-------TTRPETMLGDTAVAV-------------NPE 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 286 lAAMLADLKqggvseaeletqekrgmdtGLRALHPVTGEPVPVwVA-NFVLMGYGTGAVMAVPGHDQRDNEVANKYGLPI 364
Cdd:PRK05729 235 -DERYKHLI-------------------GKTVILPLVGREIPI-IAdEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPM 293
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 365 KQVIAlKDARTEEernwdgsrwqdwysdksrafelvNSAEFDGLD-FQgAFEALAERFE--------------------- 422
Cdd:PRK05729 294 INIMD-EDGTINE-----------------------NPGEYQGLDrFE-ARKAIVADLEelgllvkiephthsvghsdrs 348
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 423 -----------------------RKAQGQRRVN---------YR-----LRDWGVSRQRYWGCPIPVIYCaKCGAVPVPE 465
Cdd:PRK05729 349 gvviepylsdqwfvkmkplakpaLEAVENGEIKfvperwektYFhwmenIQDWCISRQLWWGHRIPAWYD-EDGEVYVGR 427
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 466 eqlpvvlpedvafsgtgspikTDPEwrkttcpDCGGAA-ERETDTFDT-FmeSS---------WyyarytsPGARDAVDk 534
Cdd:PRK05729 428 ---------------------EEPE-------AREKALlTQDEDVLDTwF--SSalwpfstlgW-------PEKTEDLK- 469
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 535 rgnYWLPVDQYIGGieHAILhlmyFrFYhkllrDARMVDS------NEPARNLLCQGMViaetyyrpnpdgskdwinpad 608
Cdd:PRK05729 470 ---RFYPTSVLVTG--FDII----F-FW-----VARMIMMglhftgQVPFKDVYIHGLV--------------------- 513
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 609 vevqRDERGRitgatliadgqpvvvggteKMSKSKNNGVDPQAMVGKYGADTVRLFSMFAAPPEQSLEWNEAGVDGMARF 688
Cdd:PRK05729 514 ----RDEQGR-------------------KMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIRFDEERVEGYRNF 570
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 689 LRRLW-----AQVQKHAADGAAPVLDVAALDANQKALRRkTHETIGKVG---DDYGrrhsFNTAIAAVMELM-NA----- 754
Cdd:PRK05729 571 ANKLWnasrfVLMNLEGADVGELPDPEELSLADRWILSR-LNRTVAEVTealDKYR----FDEAARALYEFIwNEfcdwy 645
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 950753960 755 --LAKFEDGSEQGRAVRQEA---LQAIVLLLNPITPHASHALWQVLGHGETL--LEDQPFPQADA 812
Cdd:PRK05729 646 leLAKPVLQEAAKRATRATLayvLEQILRLLHPFMPFITEELWQKLAPLGIEesIMLAPWPEADE 710
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
6-812 |
3.39e-41 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 163.30 E-value: 3.39e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 6 PNVYDPQQVESAAQKYWDATRAFEVDETSDKPKYyCLsMLPYP--SGALHMGHVRNYTIGDVISRYKRMTGHNVL-QP-- 80
Cdd:COG0525 4 PKTYDPKEVEAKWYQYWEENGYFKADPDSDKEPF-TI-VIPPPnvTGSLHMGHALNNTLQDILIRYKRMQGYNTLwQPgt 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 81 ------------------------MGWDAFglpaenaaIKnktapAAWTYKNI--DHMRSQLQSLGYAIDWSRE-FaTCR 133
Cdd:COG0525 82 dhagiatqavverqlaeegksrhdLGREKF--------LE-----RVWEWKEEsgGTITNQLRRLGASCDWSRErF-TMD 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 134 PDYY--VheQRMFTRLMRKGLAYRRNAVVNWDPVDQTVLANEQvidgrgwrsgalVEKREIPQ--WFLRitdYaqELLDG 209
Cdd:COG0525 148 EGLSkaV--REVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLE------------VEHEEVKGhlWHIR---Y--PLADG 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 210 ldeldgwpesvktmqrnwigrSEGLEIqfdvrdvdgsAldplrvfTTRPDTVMGVTFVsiaAEHPlalhaaknNPElaaM 289
Cdd:COG0525 209 ---------------------SGYIVV----------A-------TTRPETMLGDTAV---AVHP--------EDE---R 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 290 LADLKqggvseaeletqekrgmdtGLRALHPVTGEPVPVwVA-NFVLMGYGTGAVMAVPGHDQRDNEVANKYGLPIKQVI 368
Cdd:COG0525 237 YKHLI-------------------GKTVILPLVGREIPI-IAdEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIL 296
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 369 AlKDARTEEernwdgsrwqdwysdksrafelvNSAEFDGLDfqgafealaeRFE-RKA---------------------- 425
Cdd:COG0525 297 D-EDGTINE-----------------------NAGKYRGLD----------RFEaRKAivadleelgllvkvephkhsvg 342
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 426 QGQR-------------------------------RVN---------YR-----LRDWGVSRQRYWGCPIPVIYCAKcGA 460
Cdd:COG0525 343 HSDRsgtviepylsdqwfvkmkplakpaieavedgEIKfvperwektYFhwmenIRDWCISRQLWWGHRIPAWYCPD-GE 421
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 461 VPVPEeqlpvvlpedvafsgtgspikTDPEwrktTCPDCGGAA-ERETDTFDT-FmeSSW------------------YY 520
Cdd:COG0525 422 VYVAR---------------------TEPE----ACAKAGSVNlTQDEDVLDTwF--SSAlwpfstlgwpektedlkyFY 474
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 521 arytsPG-----ARDavdkrgnywlpvdqyiggiehaILhlmyFrFYhkllrDARMVDS------NEPARNLLCQGMVia 589
Cdd:COG0525 475 -----PTsvlvtGFD----------------------II----F-FW-----VARMIMMglhftgEVPFKDVYIHGLV-- 515
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 590 etyyrpnpdgskdwinpadvevqRDERGRitgatliadgqpvvvggteKMSKSKNNGVDPQAMVGKYGADTVRLFSMFAA 669
Cdd:COG0525 516 -----------------------RDEQGR-------------------KMSKSKGNVIDPLDLIDKYGADALRFTLAALA 553
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 670 PPEQSLEWNEAGVDGMARFLRRLW-----AQVQKHAADGAAPVLDVAALDANqKALRRKTHETIGKVGDDYgrrHSFNTA 744
Cdd:COG0525 554 SPGRDIKFDEERVEGYRNFANKLWnasrfVLMNLEGFDPGLDPDPEELSLAD-RWILSRLNKTIAEVTEAL---EKYRFD 629
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 745 IAAvmelmNALAKF------------------EDGSEQGRAVRQ---EALQAIVLLLNPITPHASHALWQVL--GHGETL 801
Cdd:COG0525 630 EAA-----QALYDFvwnefcdwylelakprlyGGDEAAKRETRAtlvYVLEQILRLLHPFMPFITEEIWQKLppRKEGES 704
|
970
....*....|.
gi 950753960 802 LEDQPFPQADA 812
Cdd:COG0525 705 IMLAPWPEADE 715
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
38-260 |
1.67e-36 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 140.25 E-value: 1.67e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 38 KYYCLSMLPYPSGALHMGHVRNYTIGDVISRYKRMTGHNVLQPMGWDAFGLPAENAA-----IKNKT--------APAAW 104
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAerkggRKKKTiwieefreDPKEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 105 TYKNIDHMRSQLQSLGYAIDWSREFATCRPDYYVHEQRMFTRLMRKGLAYRRNAVVnwdpvdqtvlaneqvidgrgwrsg 184
Cdd:cd00668 81 VEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHPV------------------------ 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 185 alvekREIPQWFLRITDYAQELLDGLDELDGWPESVKTMQRNW--------IGRSE--GLEIQFDVRDV--DgSALDPLR 252
Cdd:cd00668 137 -----RITEQWFFDMPKFKEKLLKALRRGKIVPEHVKNRMEAWleslldwaISRQRywGTPLPEDVFDVwfD-SGIGPLG 210
|
....*...
gi 950753960 253 VFTTRPDT 260
Cdd:cd00668 211 SLGYPEEK 218
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
9-795 |
3.35e-34 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 141.67 E-value: 3.35e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 9 YDPQQVESAAQKYWDATRAFEVDET-SDKPKYYCLSMLPYPSGALHMGHVRNYTIGDVISRYKRMTGHNVLQPMGWDAFG 87
Cdd:PRK14900 19 YEHREVEARWYPFWQERGYFHGDEHdRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 88 LPAENAAIK--NKTAPA---------------AWTYKNIDHMRSQLQSLGYAIDWSREFATCRPDYYVHEQRMFTRLMRK 150
Cdd:PRK14900 99 IATQMIVEKelKKTEKKsrhdlgreaflervwAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHEE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 151 GLAYRRNAVVNWDPVDQTVLANEQvidgrgwrsgalVEKREIPQWflRITDYAQELLDGLDEldgwpesvktmqrnwigr 230
Cdd:PRK14900 179 GLIYREKKLINWCPDCRTALSDLE------------VEHEEAHQG--ELWSFAYPLADGSGE------------------ 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 231 segleiqfdvrdvdgsaldpLRVFTTRPDTVMGVTFVSIaaeHPLalhaaknnpelaamladlkqggvseaeletqEKRG 310
Cdd:PRK14900 227 --------------------IVVATTRPETMLGDTAVAV---HPL-------------------------------DPRY 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 311 MD-TGLRALHPVTGEPVPVwVANFVLMG--YGTGAVMAVPGHDQRDNEVANKYGLPIKQVIAlKDAR-TEEERNWDGsrw 386
Cdd:PRK14900 253 MAlHGKKVRHPITGRTFPI-VADAILVDpkFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIG-PDGRmTAEAGPLAG--- 327
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 387 QDWYSDKSRAFELVnsAEfDGLDfQGA----------------------------FEALAE-RFERKAQGQRRV------ 431
Cdd:PRK14900 328 LDRFEARKEVKRLL--AE-QGLD-RGAkphvlplgrcqrsatilepllsdqwyvrIEPLARpAIEAVEQGRTRFipeqwt 403
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 432 -NY-----RLRDWGVSRQRYWGCPIPVIYCAKcGAVPVPEEQlpvvlPEdvafsgtgspiktdpewrktTCPDCGGAAER 505
Cdd:PRK14900 404 nTYmawmrNIHDWCISRQLWWGHQIPAWYCPD-GHVTVARET-----PE--------------------ACSTCGKAELR 457
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 506 E-TDTFDTFMESS-WYYARYTSPgaRDAVDKRGNYwlPVDQYIGGiehailHLMYFRFYHKLLRDARMVDSNEPARNLLC 583
Cdd:PRK14900 458 QdEDVLDTWFSSGlWPFSTMGWP--EQTDTLRTFY--PTSVMETG------HDIIFFWVARMMMMGLHFMGEVPFRTVYL 527
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 584 QGMViaetyyrpnpdgskdwinpadvevqRDERGritgatliadgqpvvvggtEKMSKSKNNGVDPQAMVGKYGADTVRl 663
Cdd:PRK14900 528 HPMV-------------------------RDEKG-------------------QKMSKTKGNVIDPLVITEQYGADALR- 562
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 664 FSMFAAPPE-QSLEWNEAGVDGMARFLRRLW-------AQVQKHAADGAAPVlDVAALDANQ---KALRRKTHETIGKVg 732
Cdd:PRK14900 563 FTLAALTAQgRDIKLAKERIEGYRAFANKLWnasrfalMNLSGYQERGEDPA-RLARTPADRwilARLQRAVNETVEAL- 640
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 950753960 733 DDYGRRHSFNTAIAAV--------MELMN-ALAKFEDGSEQG-RAVRQEALQAIVLLLNPITPHASHALWQVL 795
Cdd:PRK14900 641 EAFRFNDAANAVYAFVwhelcdwyIELAKeALASEDPEARRSvQAVLVHCLQTSYRLLHPFMPFITEELWHVL 713
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
15-663 |
1.05e-27 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 120.65 E-value: 1.05e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 15 ESAAQKYWDATRAFE-VDETSDKPKYYCLSMLPYPSGALHMGHVRNYTIGDVISRYKRMTGHNVLQPMGWDAFGLPAE-- 91
Cdd:PLN02843 9 EPEIQKLWEENQVYKrVSDRNNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIElk 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 92 -----NAAIKNKTAP-------AAWTYKNIDHMRSQLQSLGYAIDWSREFATCRPDYYVHEQRMFTRLMRKGLAYRRNAV 159
Cdd:PLN02843 89 vlqslDQEARKELTPiklrakaAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGRKP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 160 VNWDPVDQTVLANEQVIDGRGWRSGALVEKreipqwfLRITDYAQELLDGLDE-LDG-----WPESVKTMQRNwIGRSEG 233
Cdd:PLN02843 169 VHWSPSSRTALAEAELEYPEGHVSKSIYVA-------FPVVSPSETSPEELEEfLPGlslaiWTTTPWTMPAN-AAVAVN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 234 LEIQFDVRDVDGSALDPLRVFTTRPDTV------MGVTFVSIAAEHPLALhAAKNNPELAAmladlkQGGVSEAELEtqe 307
Cdd:PLN02843 241 DKLQYSVVEVQSFSEDESTSGGNKKKRPgnvlkeQQKLFLIVATDLVPAL-EAKWGVKLVV------LKTFPGSDLE--- 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 308 krgmdtGLRALHPVTGEPVPVWVA-NFVLMGYGTGAVMAVPGHDQRDNEVANKYGLPIKQVIALKDARTEEERNWDGSRW 386
Cdd:PLN02843 311 ------GCRYIHPLYNRESPVVIGgDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQFSGLSV 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 387 Q-----------------------------DWYSDKSRAFELVNS--AEFDGLDfQGAFEALAERFERKAQGQRR----V 431
Cdd:PLN02843 385 LgegnaavvealdeagsllmeeayghkypyDWRTKKPTIFRATEQwfASVEGFR-QAALDAIDKVKWIPAQGENRiramV 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 432 NYRlRDWGVSRQRYWGCPIPVIYCAKCGAVPVPEEQLPVVlPEDVAFSGTGSPIKTD-----PEWRKTTCPDcggaAERE 506
Cdd:PLN02843 464 SGR-SDWCISRQRTWGVPIPVFYHVETKEPLMNEETIAHV-KSIVAQKGSDAWWYMDvedllPEKYRDKASD----YEKG 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 507 TDTFDTFMES--SWyyarytspgaRDAVDKRGNYWLPVDQYIGGIEHailHLMYFRfyHKLLRDarmVDSN--EPARNLL 582
Cdd:PLN02843 538 TDTMDVWFDSgsSW----------AGVLGSREGLSYPADLYLEGSDQ---HRGWFQ--SSLLTS---VATKgkAPYKSVL 599
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 583 CQGMVIaetyyrpnpdgskdwinpadvevqrDERGritgatliadgqpvvvggtEKMSKSKNNGVDPQAMV--GK----- 655
Cdd:PLN02843 600 THGFVL-------------------------DEKG-------------------FKMSKSLGNVVDPRLVIegGKnqkqe 635
|
730
....*....|
gi 950753960 656 --YGADTVRL 663
Cdd:PLN02843 636 paYGADVLRL 645
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
37-228 |
1.65e-26 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 111.56 E-value: 1.65e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 37 PKYYCLSMLPYPSGALHMGHVRNYTIGDVISRYKRMTGHNVLQPMGWDAFGLPAENAA-----IKNKTAPAAWT------ 105
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVekelgISGKKDIEKMGiaefna 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 106 ------YKNIDHMRSQLQSLGYAIDWSREFATCRPDYYVHEQRMFTRLMRKGLAYRRNAVVNWdPVDQtvlaneqvidgr 179
Cdd:cd00818 81 kcrefaLRYVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW-PLIY------------ 147
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 950753960 180 gwrsgalvekREIPQWFLRITDYAQELLDGLDELDGWPESVKTMQRNWI 228
Cdd:cd00818 148 ----------RATPQWFIRVTKIKDRLLEANDKVNWIPEWVKNRFGNWL 186
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
38-235 |
1.51e-24 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 105.31 E-value: 1.51e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 38 KYYCLSMLPYPSGALHMGHVRNYTIGDVISRYKRMTGHNVLQPMGWDAFGLPAENAAIKNKTAPAAWTYKNIDHMRSQLQ 117
Cdd:cd00814 1 KVLITTALPYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGVTPQELCDKYHEIFKDLFK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 118 SLGYAID-WSRefaTCRPDYYVHEQRMFTRLMRKGLAYRRNAVVNWDPVDQTVLAneqvidgrgwrsgalvEKREIPQWF 196
Cdd:cd00814 81 WLNISFDyFIR---TTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLP----------------EWREEEHYF 141
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 950753960 197 LRITDYAQELLDGLD--ELDGWPESVKTMQRNWIgrSEGLE 235
Cdd:cd00814 142 FRLSKFQDRLLEWLEknPDFIWPENARNEVLSWL--KEGLK 180
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
20-809 |
1.08e-23 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 107.72 E-value: 1.08e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 20 KYWDATRAFE--VDETSDKpkyYCLSMLPyP--SGALHMGHVRNYTIGDVISRYKRMTGHNVLQPMGWDAFGLPAENAAI 95
Cdd:PLN02943 71 NWWESQGYFKpnFDRGGDP---FVIPMPP-PnvTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQLVVE 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 96 KNKTAPA----------------AWTYKNIDHMRSQLQSLGYAIDWSREFATCRPDYYVHEQRMFTRLMRKGLAYRRNAV 159
Cdd:PLN02943 147 KMLASEGikrtdlgrdeftkrvwEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGSYM 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 160 VNWDPVDQTVLANEQVidgrgwrsgalvekreipqwflritDYAQElldgldeldgwpesvktmqrnwigrsEGLEIQFD 239
Cdd:PLN02943 227 VNWSPNLQTAVSDLEV-------------------------EYSEE--------------------------PGTLYYIK 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 240 VRdVDGSALDPLRVFTTRPDTVMGVTFVSIaaehplalhaaknNPElaamladlkqggvseaeletQEKRGMDTGLRALH 319
Cdd:PLN02943 256 YR-VAGGSEDFLTIATTRPETLFGDVAIAV-------------NPE--------------------DDRYSKYIGKMAIV 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 320 PVT-GEPVPVWVANFVLMGYGTGAVMAVPGHDQRDNEVANKYGLPIKQVIAlKDARTEEERN--WDGSRWQDWySD---- 392
Cdd:PLN02943 302 PMTyGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMN-KDGTLNEVAGlyWFEAREKLW-SDleet 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 393 ---------------KSRAFE----LVNSAEFDGLD----------FQGAFEALAERFErKAQGQRRVNyrLRDWGVSRQ 443
Cdd:PLN02943 380 glavkkephtlrvprSQRGGEviepLVSKQWFVTMEplaekalkavENGELTIIPERFE-KIYNHWLSN--IKDWCISRQ 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 444 RYWGCPIPVIYC--AKCgavpvpEEQLPVVLPEDVAFSGTGSPIKTDPEwrkttcpdcggaAERETDTFDTFMESSWYya 521
Cdd:PLN02943 457 LWWGHRIPVWYIvgKDC------EEDYIVARSAEEALEKAREKYGKDVE------------IYQDPDVLDTWFSSALW-- 516
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 522 RYTSPGARDAVDKRGNYWLPVDQYIGGieHAILHLMYfrfyhkllrdARMV------DSNEPARNLLCQGMViaetyyrp 595
Cdd:PLN02943 517 PFSTLGWPDVSAEDFKKFYPTTVLETG--HDILFFWV----------ARMVmmgiefTGTVPFSYVYLHGLI-------- 576
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 596 npdgskdwinpadvevqRDERGRitgatliadgqpvvvggteKMSKSKNNGVDPQAMVGKYGADTVRlFSMFAAPPEQSL 675
Cdd:PLN02943 577 -----------------RDSQGR-------------------KMSKTLGNVIDPLDTIKEFGTDALR-FTLALGTAGQDL 619
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 676 EWNEAGVDGMARFLRRLWaQVQKHAADGAAPVLDVAA--------LDANQKALR---------RKTHETIGKVGDDYgRR 738
Cdd:PLN02943 620 NLSTERLTSNKAFTNKLW-NAGKFVLQNLPSQSDTSAwehilackFDKEESLLSlplpecwvvSKLHELIDSVTTSY-DK 697
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 739 HSFNTAIAAVMELM-------------NALAKFEDGS--EQGRAVRQEALQAIVLLLNPITPHASHALWQVLGHGETLLE 803
Cdd:PLN02943 698 YFFGDVGREIYDFFwsdfadwyieaskTRLYHSGDNSalSRAQAVLLYVFENILKLLHPFMPFVTEELWQALPYRKEALI 777
|
....*.
gi 950753960 804 DQPFPQ 809
Cdd:PLN02943 778 VSPWPQ 783
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
39-244 |
4.56e-23 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 102.37 E-value: 4.56e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 39 YYCLSMLPYPSGALHMGHVRNYTIGDVISRYKRMTGHNVLQPMGWDAFGLPAENAAIKNKTAPAAWTYKNIDHMRSQLQS 118
Cdd:pfam09334 1 ILVTTALPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGITPEELVDRYHEIHREDFKK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 119 LGYAIDwsrefatcrpDYY-----VHE---QRMFTRLMRKGLAYRRNAVVNWDPVDQTVLANEQVI---------DGRGW 181
Cdd:pfam09334 81 FNISFD----------DYGrttseRHHelvQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVEgtcphcgseDARGD 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 182 R--------------------SGALVEKREIPQWFLRITDYAQELLDGLDELD-GWPESVKTMQRNWIgrSEGLEiQFDV 240
Cdd:pfam09334 151 QcencgrhleptelinpkcviCGTTPEVKETEHYFFDLSKFQDKLREWIEENNpEWPENVKNMVLEWL--KEGLK-DRAI 227
|
....*
gi 950753960 241 -RDVD 244
Cdd:pfam09334 228 sRDLD 232
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
37-244 |
6.94e-23 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 103.65 E-value: 6.94e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 37 PKYYCLSMLPYPSGALHMGHVRNYTIGDVISRYKRMTGHNVLQPMGWDAFGLPAENAAIKNKTAPAAWTYKNIDHMRSQL 116
Cdd:COG0143 1 KKFLVTTAIPYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKEGITPQELVDRIHAEFKELF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 117 QSLGyaIDWsrefatcrpDYYV------HE---QRMFTRLMRKGLAYRRNAVVNWDPVDQT------------------- 168
Cdd:COG0143 81 EKLG--ISF---------DNFIrttspeHKelvQEIFQRLYDNGDIYKGEYEGWYCPECERflpdryvegtcpkcgaeda 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 169 ----------VLANEQVIDGRGWRSGALVEKREIPQWFLRITDYAQELLDGLDELDGWPESVKTMQRNWIgrSEGLEiQF 238
Cdd:COG0143 150 ygdqcencgaTLEPTELINPRSAISGAPPELREEEHYFFRLSKYQDRLLEWIEENPDIQPEVRNEVLSWL--KEGLQ-DL 226
|
....*..
gi 950753960 239 DV-RDVD 244
Cdd:COG0143 227 SIsRDFD 233
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
1-454 |
2.25e-22 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 103.44 E-value: 2.25e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 1 MTSVEPNVYDPQQVESAAQKYWDATRAFEVDETSDKPKYYCLSMLPYPSGALHMGHVRNYTIGDVISRYKRMTGHNVLQP 80
Cdd:PLN02381 92 LSSQMAKQYSPSAVEKSWYAWWEKSGYFGADAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWV 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 81 MGWDAFGLPAENAAIKN---------------KTAPAAWTYKNI--DHMRSQLQSLGYAIDWSREFATcrpdyyVHEQR- 142
Cdd:PLN02381 172 PGVDHAGIATQVVVEKKlmrerhltrhdigreEFVSEVWKWKDEygGTILNQLRRLGASLDWSRECFT------MDEQRs 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 143 -----MFTRLMRKGLAYRRNAVVNWDPVDQTVLANEQV--IDGRGwRSGALVEKREIPQWFLRITDYAQELLDGLDEldg 215
Cdd:PLN02381 246 kavteAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEVdyIDIKE-RTLLKVPGYDKPVEFGVLTSFAYPLEGGLGE--- 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 216 wpesvktmqrnwigrsegleiqfdvrdvdgsaldpLRVFTTRPDTVMGVTFVSIAAEHPLALHAAknnpelaamladlkq 295
Cdd:PLN02381 322 -----------------------------------IVVATTRIETMLGDTAIAIHPDDERYKHLH--------------- 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 296 ggvseaeletqekrgmdtGLRALHPVTGEPVPVWV-ANFVLMGYGTGAVMAVPGHDQRDNEVANKY-------------- 360
Cdd:PLN02381 352 ------------------GKFAVHPFNGRKLPIICdAILVDPNFGTGAVKITPAHDPNDFEVGKRHnlefiniftddgki 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 361 ---------GLP-----------IKQVIALKDARTEEERNWDGSRWQDWYSDKSRAFELVNSAEFDGLDFQGAFEALAER 420
Cdd:PLN02381 414 nsnggsefaGMPrfaareavieaLQKKGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWFVNCSSMAKQALDAAIDGENKK 493
|
490 500 510
....*....|....*....|....*....|....*...
gi 950753960 421 FE----RKAQGQRRVNYRLRDWGVSRQRYWGCPIPVIY 454
Cdd:PLN02381 494 LEfipkQYLAEWKRWLENIRDWCISRQLWWGHRIPAWY 531
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
6-471 |
3.35e-22 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 102.78 E-value: 3.35e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 6 PNVYDPQQVESAAQKYWDAT---RAFEVDETSDKPKYYcLSMLPYP--SGALHMGHVRNYTIGDVISRYKRMTGHNVLQP 80
Cdd:PTZ00419 25 AASYDPKEVESGWYEWWEKSgffKPAEDAKSLNSGKKF-VIVLPPPnvTGYLHIGHALTGAIQDSLIRYHRMKGDETLWV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 81 MGWDAFGLPAENAAIK------NKTAPA-----------AWTYKNIDHMRSQLQSLGYAIDWSREFATcrpdyyVHEQR- 142
Cdd:PTZ00419 104 PGTDHAGIATQVVVEKklmkeeNKTRHDlgreeflkkvwEWKDKHGNNICNQLRRLGSSLDWSREVFT------MDEQRs 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 143 -----MFTRLMRKGLAYRRNAVVNWDPVDQTVLaneqvidgrgwrSGALVEKREIPQ-WFLRITDYaqellDGLDELdGW 216
Cdd:PTZ00419 178 kavkeAFVRLYEDGLIYRDTRLVNWCCYLKTAI------------SDIEVEFEEIEKpTKITIPGY-----DKKVEV-GV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 217 PESVKTMqrnwigrsegleiqfdvrdVDGSALDPLRVFTTRPDTVMGVTFVSIaaeHPLalhaaknnpelaamladlkqg 296
Cdd:PTZ00419 240 LWHFAYP-------------------LEDSGQEEIVVATTRIETMLGDVAVAV---HPK--------------------- 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 297 gvseaeletqEKRGMD-TGLRALHP-VTGEPVPVwVAN--FVLMGYGTGAVMAVPGHDQRDNEVANKYGLPIKQVIALKD 372
Cdd:PTZ00419 277 ----------DERYKKlHGKELIHPfIPDRKIPI-IADdeLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFTLDG 345
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 373 ARTEEERNWDG---------------------------------SRWQD---------WYSD----KSRAFELVNSAEfd 406
Cdd:PTZ00419 346 KINENGGEFAGmhrfdcrrkieeelkemgllrdkvpnpmrlprcSRSGDivepmlipqWYVNckdmAKRAVEAVRNGE-- 423
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 950753960 407 gldfqgaFEALAERFErkaqgqrRVNYR----LRDWGVSRQRYWGCPIPVIYCAKCGAVPVPEEQLPVV 471
Cdd:PTZ00419 424 -------LKIIPSSHE-------NVWYHwlenIQDWCISRQLWWGHRIPAYRVISKGPETDPSDEEPWV 478
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
633-803 |
1.27e-15 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 80.93 E-value: 1.27e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 633 VGGtEKMSKSKNNGVDPQAMVGKYGADTVRLFSMFAAPPEQSLEWNEAG---------VDGMARFLRRLWAQVQKHaADG 703
Cdd:COG0143 323 VEG-EKMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPFGQDGDFSWEDfvarvnsdlANDLGNLASRTLSMIHKY-FDG 400
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 704 AAPvlDVAALDANQKALRRKTHETIGKVGDDYGRRHsFNTAIAAVMEL---MN---------ALAKFEDGSEQGRAVRQ- 770
Cdd:COG0143 401 KVP--EPGELTEADEELLAEAEAALEEVAEAMEAFE-FRKALEEIMALaraANkyidetapwKLAKDEDPERLATVLYTl 477
|
170 180 190
....*....|....*....|....*....|....
gi 950753960 771 -EALQAIVLLLNPITPHASHALWQVLGHGETLLE 803
Cdd:COG0143 478 lEALRILAILLKPFLPETAEKILEQLGLEGDELT 511
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
38-221 |
4.95e-15 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 78.77 E-value: 4.95e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 38 KYYCLSMLPYPSGALHMGHVRNYTIGDVISRYKRMTGHNVLQPMGWDAFGLPAENAAIKNKTAPAAWTYKNIDHMRSQLQ 117
Cdd:PRK11893 2 KFYITTPIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAEEAGISPQELADRNSAAFKRLWE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 118 SLGYAID-WSRefaTCRPDYYVHEQRMFTRLMRKGLAYRRNAVVNWDPVDQTVLANEQVIDGRGW--RSGALVEKREIPQ 194
Cdd:PRK11893 82 ALNISYDdFIR---TTDPRHKEAVQEIFQRLLANGDIYLGKYEGWYCVRCEEFYTESELIEDGYRcpPTGAPVEWVEEES 158
|
170 180
....*....|....*....|....*....
gi 950753960 195 WFLRITDYAQELLDGLDELDGW--PESVK 221
Cdd:PRK11893 159 YFFRLSKYQDKLLELYEANPDFiqPASRR 187
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
622-804 |
1.06e-14 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 77.61 E-value: 1.06e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 622 ATLIADGQPV----------VVGGtEKMSKSKNNGVDPQAMVGKYGADTVRLFSMFAAPPEQS--------LEW-NEAGV 682
Cdd:PRK11893 274 AFLMAAGLPLpkrvfahgflTLDG-EKMSKSLGNVIDPFDLVDEYGVDAVRYFLLREIPFGQDgdfsreafINRiNADLA 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 683 DGMARFLRRLWAQVQKHaADGAAPvlDVAALDANQKALRRKTHETIGKVGDDYGRRhSFNTAIAAVMELMNALAKFEDGS 762
Cdd:PRK11893 353 NDLGNLAQRTLSMIAKN-FDGKVP--EPGALTEADEALLEAAAALLERVRAAMDNL-AFDKALEAILALVRAANKYIDEQ 428
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 950753960 763 -------------EQGRAVRQEALQAIVLLLNPITPHASHALWQVLGHGETLLED 804
Cdd:PRK11893 429 apwslaktdperlATVLYTLLEVLRGIAVLLQPVMPELAAKILDQLGVEEDENRD 483
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
718-840 |
6.03e-14 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 69.74 E-value: 6.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 718 KALRRKTHETIGKVGDDYgRRHSFNTAIAAVMELM-NALAKF-----------EDGSEQGRAVRQEALQAIVLLLNPITP 785
Cdd:pfam08264 2 RWILSRLNKLIKEVTEAY-ENYRFNTAAQALYEFFwNDLSDWylelikdrlygEEPDSRAQTTLYEVLETLLRLLAPFMP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 786 HASHALWQvlghgETLLEDQPFPQADAGALV-----RDALTLAVQVNGKLRGTIEVAADA 840
Cdd:pfam08264 81 FITEELWQ-----KESIHLAPWPEDAELEEAeleeaFELRQEIVQAIRKLRSELKIKKSL 135
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
45-244 |
9.37e-12 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 68.64 E-value: 9.37e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 45 LPYPSGALHMGHVRNYTIGDVISRYKRMTGHNVLQPMGWDAFGLPAENAAIKNKTAPAAW--TYKNIdHMRSqLQSLGYA 122
Cdd:PRK00133 10 LPYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKEGITPEELiaRYHAE-HKRD-FAGFGIS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 123 ID-WSRefaTCRPDYYVHEQRMFTRLMRKGLAYRRNAVVNWDPVDQTVL-------------ANEQ-------------- 174
Cdd:PRK00133 88 FDnYGS---THSEENRELAQEIYLKLKENGYIYEKTIEQLYDPEKGMFLpdrfvkgtcpkcgAEDQygdncevcgatysp 164
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 950753960 175 --VIDGRGWRSGALVEKREIPQWFLRITDYAQELLDGLDELDGWPESVKTMQRNWIgrSEGLEiQFDV-RDVD 244
Cdd:PRK00133 165 teLINPKSAISGATPVLKESEHFFFKLPRFEEFLKEWITRSGELQPNVANKMKEWL--EEGLQ-DWDIsRDAP 234
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
4-92 |
2.63e-11 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 67.83 E-value: 2.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 4 VEPNVYDPQQVESAAQKYWDATRAFE--VDETSDKPKYYCLSMLPYPSGALHMGHVRNYTIGDVISRYKRMTGHNVLQPM 81
Cdd:PLN02882 3 CEGKDFSFPKQEEKILSLWSEIDAFKtqLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRF 82
|
90
....*....|.
gi 950753960 82 GWDAFGLPAEN 92
Cdd:PLN02882 83 GWDCHGLPVEY 93
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
637-804 |
3.46e-11 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 66.75 E-value: 3.46e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 637 EKMSKSKNNGVDPQAMVGKYGADTVRLFSMFAAPpeqslewneAGVDG-------MARF-----------LRRLWAQVQK 698
Cdd:PRK12267 298 GKMSKSKGNVVDPEELVDRYGLDALRYYLLREVP---------FGSDGdfspealVERInsdlandlgnlLNRTVAMINK 368
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 699 HaADGAAP-VLDVAALDAnqkALRRKTHETIGKVgDDYGRRHSFNTAIAAVMEL---MN---------ALAKFEDGSEQG 765
Cdd:PRK12267 369 Y-FDGEIPaPGNVTEFDE---ELIALAEETLKNY-EELMEELQFSRALEEVWKLisrANkyidetapwVLAKDEGKKERL 443
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 950753960 766 RAVRQ---EALQAIVLLLNPITPHASHALWQVLGHGETLLED 804
Cdd:PRK12267 444 ATVMYhlaESLRKVAVLLSPFMPETSKKIFEQLGLEEELTSW 485
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
631-857 |
1.10e-08 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 58.58 E-value: 1.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 631 VVVGGtEKMSKSKNNGVDPQAMVGKYGADTVRLFsMFAAPPEQSLEWNEAGVDGMARFLRRLWAQVQKHAADGAAPVLDV 710
Cdd:COG0215 259 LTVNG-EKMSKSLGNFFTVRDLLKKYDPEVLRFF-LLSAHYRSPLDFSEEALEEAEKALERLYNALRRLEEALGAADSSA 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 711 AALDanqkALRRKTHETIgkvGDDygrrhsFNT--AIAAVMELMNALAKFEDGSEqGRAVRQEALQAIVLLLnpitphas 788
Cdd:COG0215 337 EEIE----ELREEFIAAM---DDD------FNTpeALAVLFELVREINKALDEGE-DKAALAALAALLRALG-------- 394
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 950753960 789 halwQVLGhgetLLEDQPFPQADAGalvrdaltlavqvngklrgtievAADAAREQVEALaLAEPNAAR 857
Cdd:COG0215 395 ----GVLG----LLLLEPEAWQGAA-----------------------EDELLDALIEAL-IEERAEAR 431
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
14-96 |
2.04e-08 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 58.16 E-value: 2.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 14 VESAAQKYWDATRAFEVDETSDKP----KYYCLSMLPYPSGALHMGHVRNYTIGDVISRYKRMTGHNVLQPMGWDAFGLP 89
Cdd:PLN02959 18 IEVAVQKWWEEEKVFEAEAGDEPPkpgeKFFGNFPYPYMNGLLHLGHAFSLSKLEFAAAYHRLRGANVLLPFAFHCTGMP 97
|
....*..
gi 950753960 90 AENAAIK 96
Cdd:PLN02959 98 IKASADK 104
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
34-151 |
3.13e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 57.50 E-value: 3.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 34 SDKPKYYCLSMLPYPSGALHMGHVrnYT--IGDVISRYKRMTGHNVLQPMGWDAFGLPAENAAIKNKTAPAAWTykniDH 111
Cdd:PRK12267 1 MMKKTFYITTPIYYPNGKPHIGHA--YTtiAADALARYKRLQGYDVFFLTGTDEHGQKIQQAAEKAGKTPQEYV----DE 74
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 950753960 112 MRSQLQSLGYAIDWSrefatcrPDYYV------HE---QRMFTRLMRKG 151
Cdd:PRK12267 75 ISAGFKELWKKLDIS-------YDKFIrttderHKkvvQKIFEKLYEQG 116
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
3-683 |
6.45e-06 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 49.97 E-value: 6.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 3 SVEPNVYDPQQvesAAQKYWDATRAFEVDE--TSDKPKYYCLSMLPYPSGALHMGHVRNYTIGDVISRYKRMTGHNVLQP 80
Cdd:PTZ00427 69 SENPNIVEEEE---KVLKYWKSIDAFNTSNklAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERK 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 81 MGWDAFGLPAE----------------NAAI---KNKTAPAAWTYKNidHMRSQLQSLGYAIDWSREFATCRPDYYVHEQ 141
Cdd:PTZ00427 146 FGWDCHGLPIEyeiekenninkkedilKMGIdvyNEKCRGIVLKYSN--EWVKTVERIGRWIDFKNDYKTMDKTFMESVW 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 142 RMFTRLMRKGLAYRRNAVVNWDPVDQTVLANEQVIdgrgwrsgalVEKREIPQ-----WFLRITDY--AQELLDGLDELD 214
Cdd:PTZ00427 224 WVFSELYKNNYVYKSFKVMPYSCKCNTPISNFELN----------LNYKDTPDpsiiiSFVLCSDFpkVEEECNIEEDKQ 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 215 GWPESVKTMQRNwiGRSEGLEIQFDVRDVDGSALD-PLRVFTTRPDTVMGVTFVSIaAEH--PLALHAAKNNP------- 284
Cdd:PTZ00427 294 LLGEKYSVLYNN--KRENSNNGNNNSTNNVCYAQHsEILAWTTTPWTLPSNLALCV-NEHftYLRIHHVKSNRvvivgec 370
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 285 ELAAMLADLKQgGVSEAELETQEKRGMDTGLR---------ALHPVTGEPVPVWVANFVLMGYGTGAVMAVPGHDQRDNE 355
Cdd:PTZ00427 371 RLEWIMKELKW-NVEDLKIVNRFKGKELKGLRykplftnfyEKYNFKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFR 449
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 356 VANKYGL----------PI-------KQVIALKDARTEEERNwdgsRWQDWYSDKSRAFE---LVNSAEFDGL-DFQGAF 414
Cdd:PTZ00427 450 VCKKNGVidpeknifidPLdangyftNEVEEVQNLYIKEADN----VIKKKLKNENRLLSnntIVHSYPFCWRsDTPLIY 525
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 415 EALAERFERKAQGQRRV------NYRL----------------RDWGVSRQRYWGCPIPvIYCakcgavpvPEEQLPVVL 472
Cdd:PTZ00427 526 RAIPAWFIRVSNSTNELvknnetTYWIpahikekkfhnwikdaKDWCISRNRYWGTPIP-IWA--------DEKMETVIC 596
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 473 PEDVAFSGTGSPIKT---------DPEWRKTTCPDCGGAAERETDTFDTFMES-SWYYARYTSPGARDAVDKRGNYwlPV 542
Cdd:PTZ00427 597 VESIKHLEELSGVKNindlhrhfiDHIEIKNPKGKTYPKLKRIPEVFDCWFESgSMPYAKVHYPFSTEKEDFHKIF--PA 674
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 543 DQYIGGIEHAilhlmyFRFYHKLLRDARMVDSNEPARNLLCQGMVIAetyyrpnpdgskdwinpadvevqrdergritga 622
Cdd:PTZ00427 675 DFIAEGLDQT------RGWFYTLLVISTLLFDKAPFKNLICNGLVLA--------------------------------- 715
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 950753960 623 tliADGQpvvvggteKMSKSKNNGVDPQAMVGKYGADTVRLFSMFA-APPEQSLEWNEAGVD 683
Cdd:PTZ00427 716 ---SDGK--------KMSKRLKNYPDPLYILDKYGADSLRLYLINSvAVRAENLKFQEKGVN 766
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
637-673 |
8.70e-06 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 48.68 E-value: 8.70e-06
10 20 30
....*....|....*....|....*....|....*..
gi 950753960 637 EKMSKSKNNGVDPQAMVGKYGADTVRLFSMFAAPPEQ 673
Cdd:cd00814 279 KKMSKSRGNVVDPDDLLERYGADALRYYLLRERPEGK 315
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
677-793 |
7.16e-05 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 42.96 E-value: 7.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 677 WNEAGVDGMARFLRRLWAQVQKHAADGAapvlDVAALDANQKALRRKTHETIGKVGDDYgrrHSFNT--AI-AAVMELMN 753
Cdd:cd07959 1 FREEEANSAILRLERFYELAEELIETEG----ELEELTFIDRWLLSRLNRLIKETTEAY---ENMQFreALkEGLYELQN 73
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 950753960 754 ALAKFED--GSEQGRAVRQEALQAIVLLLNPITPHASHALWQ 793
Cdd:cd07959 74 DLDWYRErgGAGMNKDLLRRFIEVWTRLLAPFAPHLAEEIWH 115
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
701-795 |
1.47e-04 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 42.48 E-value: 1.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 701 ADGAAPVLDvaALDANQKALRRKTHETIGKVGDDYGRRHsFNTAIAAVMEL---MN---------ALAKFEDGSEQGRAV 768
Cdd:cd07957 24 FGGVVPEFG--GLTEEDEELLEEAEELLEEVAEAMEELE-FRKALEEIMELaraANkyidetapwKLAKEEDPERLATVL 100
|
90 100
....*....|....*....|....*....
gi 950753960 769 RQ--EALQAIVLLLNPITPHASHALWQVL 795
Cdd:cd07957 101 YVllELLRILAILLSPFMPETAEKILDQL 129
|
|
| ArgRS_core |
cd00671 |
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic ... |
46-78 |
4.48e-04 |
|
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. There are at least three subgroups of ArgRS. One type contains both characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. The second subtype lacks the KMSKS motif; however, it has a lysine N-terminal to the HIGH motif, which serves as the functional counterpart to the second lysine of the KMSKS motif. A third group, which is found primarily in archaea and a few bacteria, lacks both the KMSKS motif and the HIGH loop lysine.
Pssm-ID: 185675 [Multi-domain] Cd Length: 212 Bit Score: 42.55 E-value: 4.48e-04
10 20 30
....*....|....*....|....*....|...
gi 950753960 46 PYPSGALHMGHVRNYTIGDVISRYKRMTGHNVL 78
Cdd:cd00671 9 ANPTGPLHVGHLRNAIIGDSLARILEFLGYDVT 41
|
|
| argS |
TIGR00456 |
arginyl-tRNA synthetase; This model recognizes arginyl-tRNA synthetase in every completed ... |
46-78 |
7.34e-04 |
|
arginyl-tRNA synthetase; This model recognizes arginyl-tRNA synthetase in every completed genome to date. An interesting feature of the alignment of all arginyl-tRNA synthetases is a fairly deep split between two families. One family includes archaeal, eukaryotic and organellar, spirochete, E. coli, and Synechocystis sp. The second, sharing a deletion of about 25 residues in the central region relative to the first, includes Bacillus subtilis, Aquifex aeolicus, the Mycoplasmas and Mycobacteria, and the Gram-negative bacterium Helicobacter pylori. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273085 [Multi-domain] Cd Length: 563 Bit Score: 43.10 E-value: 7.34e-04
10 20 30
....*....|....*....|....*....|...
gi 950753960 46 PYPSGALHMGHVRNYTIGDVISRYKRMTGHNVL 78
Cdd:TIGR00456 121 ANPAGPLHVGHLRNAIIGDSLARILEFLGYDVI 153
|
|
| PLN02610 |
PLN02610 |
probable methionyl-tRNA synthetase |
43-101 |
2.83e-03 |
|
probable methionyl-tRNA synthetase
Pssm-ID: 215329 [Multi-domain] Cd Length: 801 Bit Score: 41.30 E-value: 2.83e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 950753960 43 SMLPYPSGALHMGHVrnytIG-----DVISRYKRMTGHNVLQPMGWDAFGLPAENAAIKNKTAP 101
Cdd:PLN02610 23 SALPYVNNVPHLGNI----IGcvlsaDVFARYCRLRGYNAIYICGTDEYGTATETKALEENCTP 82
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
679-784 |
3.31e-03 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 38.26 E-value: 3.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 679 EAGVDGMARFLRRLW--AQVQKHAADGAAPVLDVAALDANQKALRRKTHETIGKVGDDYgRRHSFNTAIAAVMELMNAL- 755
Cdd:cd07375 1 EERLKQARAFLNRLYrlLSFFRKALGGTQPKWDNELLEEADRELLARLQEFIKRTTNAL-EALDPTTAVQELFKFTNELn 79
|
90 100 110
....*....|....*....|....*....|....*...
gi 950753960 756 ---------AKFEDGSEQGRAVRQEALQAIVLLLNPIT 784
Cdd:cd07375 80 wyldelkpaLQTEELREAVLAVLRAALVVLTKLLAPFT 117
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
53-157 |
5.32e-03 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 40.09 E-value: 5.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 950753960 53 HMGHVRNYTIGDVISRYKRMTGHNVLQpmgwdafglpAEN----------AAIKNKTAPAAWTYKNIDHMRSQLQSLGya 122
Cdd:COG0215 37 HIGHARTFVVFDVLRRYLRYLGYKVTY----------VRNitdvddkiikRAAEEGESIWELAERYIAAFHEDMDALG-- 104
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 950753960 123 idwsrefaTCRPDYY------VHEQ-RMFTRLMRKGLAYRRN 157
Cdd:COG0215 105 --------VLPPDIEpratehIPEMiELIERLIEKGHAYEAD 138
|
|
| ArgS |
COG0018 |
Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Arginyl-tRNA ... |
48-77 |
8.78e-03 |
|
Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Arginyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439789 [Multi-domain] Cd Length: 574 Bit Score: 39.75 E-value: 8.78e-03
10 20 30
....*....|....*....|....*....|
gi 950753960 48 PSGALHMGHVRNYTIGDVISRYKRMTGHNV 77
Cdd:COG0018 127 PTKPLHVGHLRGAVIGDALARILEAAGYDV 156
|
|
| |
