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Conserved domains on  [gi|951093158|ref|WP_057584847|]
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MULTISPECIES: GntR family transcriptional regulator [unclassified Streptomyces]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
34-261 8.80e-70

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 214.73  E-value: 8.80e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158  34 QLADLLRRQLLTGGFPAGT-LPHEATLAADYRASRNTVREALDLLRAEGLVERLPGVGTIVVAQKYPHGLDRLMGLAETL 112
Cdd:COG2188    9 QIADALRERIESGELPPGDrLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTSFTEEL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158 113 HEHGH-VTNEVRTMGPVAAPAPVADRLRVPPGADVLYIERLRRLGGVPLSLDLTYVPLDIGVDLLGADLENTDVFRLLEA 191
Cdd:COG2188   89 RARGRePSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETGSLYELLEE 168

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158 192 LTGQRLGHAEITLEAVNADAHSAAVLEAPRGAAVLMLERLTHLADGRPVDLEFIRFRGDRISMSGQLHRS 261
Cdd:COG2188  169 RYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRRR 238
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
34-261 8.80e-70

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 214.73  E-value: 8.80e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158  34 QLADLLRRQLLTGGFPAGT-LPHEATLAADYRASRNTVREALDLLRAEGLVERLPGVGTIVVAQKYPHGLDRLMGLAETL 112
Cdd:COG2188    9 QIADALRERIESGELPPGDrLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTSFTEEL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158 113 HEHGH-VTNEVRTMGPVAAPAPVADRLRVPPGADVLYIERLRRLGGVPLSLDLTYVPLDIGVDLLGADLENTDVFRLLEA 191
Cdd:COG2188   89 RARGRePSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETGSLYELLEE 168

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158 192 LTGQRLGHAEITLEAVNADAHSAAVLEAPRGAAVLMLERLTHLADGRPVDLEFIRFRGDRISMSGQLHRS 261
Cdd:COG2188  169 RYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRRR 238
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 113-253 3.44e-37

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 128.10  E-value: 3.44e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158  113 HEHGHVTNEVRTMGPVAAPAPVADRLRVPPGADVLYIERLRRLGGVPLSLDLTYVPLDIGVDLLGADLENTDVFRLLEAL 192
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 951093158  193 TGQRLGHAEITLEAVNADAHSAAVLEAPRGAAVLMLERLTHLADGRPVDLEFIRFRGDRIS 253
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 115-253 1.87e-31

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 113.16  E-value: 1.87e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158   115 HGHVTNEVRTMGPVAAPAPVADRLRVPPGADVLYIERLRRLGGVPLSLDLTYVPLDIGVDLLGADLEN--TDVFRLLEAL 192
Cdd:smart00866   3 GRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGslYEYLEERLGL 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 951093158   193 TGQRLGHAEITLEAVNADAHSAAVLEAPRGAAVLMLERLTHLADGRPVDLEFIRFRGDRIS 253
Cdd:smart00866  83 KIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 34-255 2.17e-27

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 105.64  E-value: 2.17e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158   34 QLADLLRRQLLTGGFPAGT-LPHEATLAADYRASRNTVREALDLLRAEGLVERLPGVGTIVVAQKYPHGLDRLMGLAETL 112
Cdd:TIGR02325  12 QIADKIEQEIAAGHLRAGDyLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLSARTRFSQNL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158  113 HEHG-HVTNEVRTMGPVAAPAPVADRLRVPPGADVLYIERLRRLGGVPLSLDLTYVPLDIGVDLLGADLENTDVFRLLEA 191
Cdd:TIGR02325  92 ADQGrEPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIGQAYAASGSITDALRE 171

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 951093158  192 LTGQRLGHAEITLEAVNADAHSAAVLEAPRGAAVLMLERLTHLADGRPVDLEFIRFRGDRISMS 255
Cdd:TIGR02325 172 QGVADYRRSSTRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADRVEFT 235
PRK11402 PRK11402
transcriptional regulator PhoB;
49-255 3.42e-21

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 89.12  E-value: 3.42e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158  49 PAGTLPHEATLAADYRASRNTVREALDLLRAEGLVERLPGVGTIVVAQKYPHGLDRLMGLAETLHEHGHVTNEVRTMGPV 128
Cdd:PRK11402  29 AGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSGFTDFGVSQGKATKEKVIEQER 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158 129 AAPAPVADRLRVPPGADVLYIERLRRLGGVPLSLDLTYVPLDIGVDLLGADLENTDVFRLLEALTGQRLGHAEITLEAVN 208
Cdd:PRK11402 109 VSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYVEGSSTYQLFQERFDTRVVSDKKTIDIFA 188

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 951093158 209 ADAHSAAVLEAPRGAAVLMLERLTHLADGRPVDLEFIRFRGDRISMS 255
Cdd:PRK11402 189 ATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTLT 235
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 34-93 9.39e-18

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 75.18  E-value: 9.39e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 951093158  34 QLADLLRRQLLTGGFPAGT-LPHEATLAADYRASRNTVREALDLLRAEGLVERLPGVGTIV 93
Cdd:cd07377    5 QIADQLREAILSGELKPGDrLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
34-261 8.80e-70

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 214.73  E-value: 8.80e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158  34 QLADLLRRQLLTGGFPAGT-LPHEATLAADYRASRNTVREALDLLRAEGLVERLPGVGTIVVAQKYPHGLDRLMGLAETL 112
Cdd:COG2188    9 QIADALRERIESGELPPGDrLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTSFTEEL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158 113 HEHGH-VTNEVRTMGPVAAPAPVADRLRVPPGADVLYIERLRRLGGVPLSLDLTYVPLDIGVDLLGADLENTDVFRLLEA 191
Cdd:COG2188   89 RARGRePSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETGSLYELLEE 168

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158 192 LTGQRLGHAEITLEAVNADAHSAAVLEAPRGAAVLMLERLTHLADGRPVDLEFIRFRGDRISMSGQLHRS 261
Cdd:COG2188  169 RYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRRR 238
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 113-253 3.44e-37

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 128.10  E-value: 3.44e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158  113 HEHGHVTNEVRTMGPVAAPAPVADRLRVPPGADVLYIERLRRLGGVPLSLDLTYVPLDIGVDLLGADLENTDVFRLLEAL 192
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 951093158  193 TGQRLGHAEITLEAVNADAHSAAVLEAPRGAAVLMLERLTHLADGRPVDLEFIRFRGDRIS 253
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 115-253 1.87e-31

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 113.16  E-value: 1.87e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158   115 HGHVTNEVRTMGPVAAPAPVADRLRVPPGADVLYIERLRRLGGVPLSLDLTYVPLDIGVDLLGADLEN--TDVFRLLEAL 192
Cdd:smart00866   3 GRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGslYEYLEERLGL 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 951093158   193 TGQRLGHAEITLEAVNADAHSAAVLEAPRGAAVLMLERLTHLADGRPVDLEFIRFRGDRIS 253
Cdd:smart00866  83 KIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 34-255 2.17e-27

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 105.64  E-value: 2.17e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158   34 QLADLLRRQLLTGGFPAGT-LPHEATLAADYRASRNTVREALDLLRAEGLVERLPGVGTIVVAQKYPHGLDRLMGLAETL 112
Cdd:TIGR02325  12 QIADKIEQEIAAGHLRAGDyLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLSARTRFSQNL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158  113 HEHG-HVTNEVRTMGPVAAPAPVADRLRVPPGADVLYIERLRRLGGVPLSLDLTYVPLDIGVDLLGADLENTDVFRLLEA 191
Cdd:TIGR02325  92 ADQGrEPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIGQAYAASGSITDALRE 171

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 951093158  192 LTGQRLGHAEITLEAVNADAHSAAVLEAPRGAAVLMLERLTHLADGRPVDLEFIRFRGDRISMS 255
Cdd:TIGR02325 172 QGVADYRRSSTRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADRVEFT 235
PRK11402 PRK11402
transcriptional regulator PhoB;
49-255 3.42e-21

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 89.12  E-value: 3.42e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158  49 PAGTLPHEATLAADYRASRNTVREALDLLRAEGLVERLPGVGTIVVAQKYPHGLDRLMGLAETLHEHGHVTNEVRTMGPV 128
Cdd:PRK11402  29 AGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSGFTDFGVSQGKATKEKVIEQER 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158 129 AAPAPVADRLRVPPGADVLYIERLRRLGGVPLSLDLTYVPLDIGVDLLGADLENTDVFRLLEALTGQRLGHAEITLEAVN 208
Cdd:PRK11402 109 VSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYVEGSSTYQLFQERFDTRVVSDKKTIDIFA 188

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 951093158 209 ADAHSAAVLEAPRGAAVLMLERLTHLADGRPVDLEFIRFRGDRISMS 255
Cdd:PRK11402 189 ATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTLT 235
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 34-93 9.39e-18

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 75.18  E-value: 9.39e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 951093158  34 QLADLLRRQLLTGGFPAGT-LPHEATLAADYRASRNTVREALDLLRAEGLVERLPGVGTIV 93
Cdd:cd07377    5 QIADQLREAILSGELKPGDrLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
PRK09764 PRK09764
GntR family transcriptional regulator;
34-238 3.11e-15

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 72.94  E-value: 3.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158  34 QLADLLRRQLLTGGFPAG-TLPHEATLAADYRASRNTVREALDLLRAEGLVERLPGVGTIVVAQKYPHGLDRLMGLAETL 112
Cdd:PRK09764   9 QIADRIREQIARGELKPGdALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLTSFDEKL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158 113 -HEHGHVTNEVRTMGPVAAPAPVADRLRVPPGADVLYIERLRRLGGVPLSLDLTYVPLDIGVDLLGADLENTDvFRLLEA 191
Cdd:PRK09764  89 sDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSK-YHFIEE 167

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 951093158 192 LTGQRLGHAEITLEAVNADAHSAAVLEAPRGAAVLMLERLTHLADGR 238
Cdd:PRK09764 168 VKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGR 214
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 34-255 5.23e-13

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 66.72  E-value: 5.23e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158  34 QLADLLRRQLLTGGFpagtLPHEATLAADYRASRNTVREALDLLRAEGLVERLPGVGTIVVAQKYPHGLDRLMGLAETLH 113
Cdd:PRK10079  20 KLEQELRQHYRCGDY----LPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPYDYPLNAQARFSQNLL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158 114 EHG-HVTNEVRTMGPVAAPAPVADRLRVPPGADVLYIERLRRLGGVPLSLDLTYVPlDIGVDLLGADLENTDVFRLLEAL 192
Cdd:PRK10079  96 DQGsHPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLIDHYFA-DLTWWPTLQRFDSGSLHDFLREQ 174

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 951093158 193 TGQRLGHAEITLEAVNADAHSAAVLEAPRGAAVLMLERLTH-LADGRPVDLEFIRFRGDRISMS 255
Cdd:PRK10079 175 LGIALRRSQTRISARRAQAKESQLLEIPNMSPLLCVRTLNHrDGESSPAEYSVSLTRADMIEFT 238
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
34-105 6.07e-13

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 66.11  E-value: 6.07e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 951093158  34 QLADLLRRQLLTGGFPAGT-LPHEATLAADYRASRNTVREALDLLRAEGLVERLPGVGTIVVAQKYPHGLDRL 105
Cdd:COG2186   11 QVAEQLRELILSGELKPGDrLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLDPL 83
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
35-93 4.28e-12

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 59.90  E-value: 4.28e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158    35 LADLLRRQLLTGGFPAGT-LPHEATLAADYRASRNTVREALDLLRAEGLVERLPGVGTIV 93
Cdd:smart00345   1 VAERLREDIVSGELRPGDkLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 34-93 4.50e-12

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 59.94  E-value: 4.50e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 951093158   34 QLADLLRRQLLTGGFPAGT-LPHEATLAADYRASRNTVREALDLLRAEGLVERLPGVGTIV 93
Cdd:pfam00392   4 QVYARLREDILSGRLRPGDkLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
34-96 5.38e-11

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 58.27  E-value: 5.38e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 951093158  34 QLADLLRRQLLTGGFPAGT-LPHEATLAADYRASRNTVREALDLLRAEGLVERLPGVGTIVVAQ 96
Cdd:COG1725   14 QIADQIKEAIASGELKPGDrLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAED 77
PRK14999 PRK14999
histidine utilization repressor; Provisional
 49-258 3.49e-10

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 58.79  E-value: 3.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158  49 PAGTLPHEATLAADYRASRNTVREALDLLRAEGLVERLPGVGTIVVAQKYPHGLDRLMGLAETLHEHGHVTN-EVRTMGP 127
Cdd:PRK14999  32 PHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQSALFEVRSIAEEIAARRHQHRcEVLTLER 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951093158 128 VAAPAPVADRLRVPPGADVLYIERLRRLGGVPLSLDLTYVPLDIGVDLLGADLENTDVFRLLEALTgqRLGHAEITLEAV 207
Cdd:PRK14999 112 VRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDYLTQDYRQTTPHAYLSRIA--PLTEGEHIVEAV 189

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 951093158 208 NADAHSAAVLEAPRGAAVLMLERLTHLAdGRPVDLEFIRFRGDRISMSGQL 258
Cdd:PRK14999 190 RATAQECAWLTIKEHEPCLLIRRTTWSA-SRIVSHARLLFPGSRYRLQGRF 239
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 34-96 3.52e-10

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 59.84  E-value: 3.52e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 951093158  34 QLADLLRRQLLTGGFPAGT-LPHEATLAADYRASRNTVREALDLLRAEGLVERLPGVGTIVVAQ 96
Cdd:COG1167   16 QLADALREAILSGRLPPGDrLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAAR 79
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
34-94 2.57e-09

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 55.70  E-value: 2.57e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 951093158  34 QLADLLRRQLLTGGFPAGTLPHEATLAADYRASRNTVREALDLLRAEGLVERLPGVGTIVV 94
Cdd:COG1802   15 QVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVA 75
PRK11523 PRK11523
transcriptional regulator ExuR;
34-99 2.44e-05

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 44.45  E-value: 2.44e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 951093158  34 QLADLLRRQLLTGGFPAG-TLPHEATLAADYRASRNTVREALDLLRAEGLVERLPGVGTIVVA--QKYP 99
Cdd:PRK11523  12 QLAAELKERIEQGVYLVGdKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSnqPRHQ 80
PRK10225 PRK10225
Uxu operon transcriptional regulator;
49-103 1.05e-03

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 39.62  E-value: 1.05e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 951093158  49 PAGTLPHEATLAADYRASRNTVREALDLLRAEGLVERLPGVGTIVVAQKYPHGLD 103
Cdd:PRK10225  29 PGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNTD 83
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
34-96 3.05e-03

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 38.08  E-value: 3.05e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 951093158  34 QLADLLRRQL----LTGGFPAG-TLPHEATLAADYRASRNTVREALDLLRAEGLVERLPGVGTIVVAQ 96
Cdd:PRK09464  10 KLSDVIEQQLefliLEGTLRPGeKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSS 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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