|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
1-640 |
0e+00 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 1127.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 1 MRLFIAEKPSLARAIADILPkPHRRGDGFIAcGSDQMVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWRLQPRPS 80
Cdd:PRK07726 1 MRLFIAEKPSVGRDIADVLK-PHKKGDGYIE-GNGYIVTWAIGHLLELAEPEAYDERYKRWRLEDLPIIPEKWKLVVKKK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 81 VSKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLDLatekRQNVRRCLINDLNPQAVERAVERLRYNREFIPLCV 160
Cdd:PRK07726 79 TAKQFNVVKKLLKQATEIVIATDADREGELIAREILDYCGV----RKPIKRLWISSLTDKAIKRAFANLKPGKETIPLYY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 161 SALARARADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIEDFVAKDFFEVKAHIVtpADERFIALW 240
Cdd:PRK07726 155 SALARSRADWLVGINMTRAYTLLGRKAGYNGVLSVGRVQTPTLALVVRRDEEIENFVPKPYWEVEAHLT--PGERFTAKW 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 241 QPSDSCEsyqDEEGRLLHRPLAEHVVNRITGQPAIVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQRLY 320
Cdd:PRK07726 233 QPSEPYQ---DEEGRLLDRPLAEQVVARIQGQPAKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKETLDIAQSLY 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 321 ETHKLITYPRSDCRYLPEEHFAGRHSVLNAIS-IHQADLLPLEVMDSDRRNRCWDDKKVDAHHAIIPTARASKVN-LTAD 398
Cdd:PRK07726 310 ETHKLITYPRTDSRYLPEDMVATLPEVLNAISkVDPYLLLAPPVLDPSIRSRAWNDKKVTAHHAIIPTEQPPNLSkLSED 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 399 ESKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEgAPLPVVEKGAELLCERG 478
Cdd:PRK07726 390 ERKVYDLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWKALLGKKEEDEEKE-QPLPVLAKGDELKVEKG 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 479 EVVERQTQPPRPFTDASLLSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRALI 558
Cdd:PRK07726 469 EVKEGQTQPPKRFTEGTLLSAMENIARFVQDKELKKTLKETDGLGTEATRAGIIEKLFKRGYLEKKGKYIHATDKGKQLI 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 559 HALPDIAARPDMTAHWESTLTQISEKNCRYQDFMQPLVATLQDLISQAKQNRSPQVFRGLPaAPSGATKKRKKTPSKAKE 638
Cdd:PRK07726 549 DALPEELTSPDMTAKWEQALDQISEGQLSYQDFMQPLKQWLKQLVEQAKQSSEKYKFDNLT-GPKCPDCGKPMLKVKGKN 627
|
..
gi 951133904 639 NK 640
Cdd:PRK07726 628 GK 629
|
|
| topB |
TIGR01056 |
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ... |
1-635 |
0e+00 |
|
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273419 [Multi-domain] Cd Length: 660 Bit Score: 946.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 1 MRLFIAEKPSLARAIADILPKPHRrGDGFIACGSDQMVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWRLQPRPS 80
Cdd:TIGR01056 1 MTLVLCEKPSQARDLATVLAKKKK-GNGYLEIGVGGFVTWAVGHLVELAEPEEYDEKYKNWRTYDLPLEPEDWQLVVSDK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 81 VSKQLNVIKQLL--QQADEVVHAGDPDREGQLLVDEVLDYLDLAteKRQNVRRCLINDLNPQAVERAVERLRYNREFIPL 158
Cdd:TIGR01056 80 TKKQFNVIKRILkeNKVDEVVIATDPDREGELIAREILDYLKVT--DKVTIKRLWISSLVDSSIRKAFKNLRPKSETEGL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 159 CVSALARARADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIEDFVAKDFFEVKAHIVTPAdERFIA 238
Cdd:TIGR01056 158 YKSGVARARADWLVGINLTRAFTKLGREAGNDGVLSVGRVQTPTLAMVVKRENEIKNFVGKPFYEVSATINKDE-QEFTT 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 239 LWQPsdscesYQDEEGRLLHRPLAEHVVNRITGQPAIVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQR 318
Cdd:TIGR01056 237 EWQP------YKDEEERELHEFLAENVVTDLTQKPALVTDIEKERKKTSAPLFYDLSALQEDANKRFGISAKRTLDIAQK 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 319 LYETHKLITYPRSDCRYLPEEHFAGRHSVLNAISIHQADLLPLEVMDSDRRNRCWDDKKVDAHHAIIPTARAS-KVNLTA 397
Cdd:TIGR01056 311 LYETHKLITYPRTDSRYLPEDEKEMLLEVLDALKVITPALLPIKKRDELTNNRLWNDKKIEDHHAIIPTGNDFnLSDLSE 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 398 DESKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGAPLPVVEKGAELLCER 477
Cdd:TIGR01056 391 EERNVYKLIAQNYLMQFMPKEEYETTTIEIAIGKLMFEAKGKILQDNGWKALLGKQEEDEETEDTTLPAFQKGDELDVET 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 478 GEVVERQTQPPRPFTDASLLSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRAL 557
Cdd:TIGR01056 471 LELLEKQTKPPARYTEGTLLSAMTNPAAFVQDKGLKKTLKETKGLGTEATRADIIENLFKRGFIQKKKNKIYITKNGKLL 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 558 IHALPDIAARPDMTAHWESTLTQISEKNCRYQDFMQPLVATLQDLISQAKqnRSPQVFRGLPAAP----SGATKKRKKTP 633
Cdd:TIGR01056 551 CLLLPELLTKPDLTAQWEQYLNGISAGEKDDDDFINTINEMIKQTINEEK--KNPETIQKVAKEPvscgGIAKCPAKDNG 628
|
..
gi 951133904 634 SK 635
Cdd:TIGR01056 629 RL 630
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
1-593 |
2.47e-152 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 450.70 E-value: 2.47e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 1 MRLFIAEKPSLARAIADILpkphrrGDGFIacgsdqmVTWCVGHLLEQAQPD-AYDsryarwslADLPIIPEkwrLQPRP 79
Cdd:COG0550 1 KKLVIVESPAKAKTIAKYL------GKDYV-------VTASVGHLRDLPKPElDVD--------VENDFEPK---YEVIP 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 80 SVSKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLDlateKRQNVRRCLINDLNPQAVERAVERLRynREFIPLC 159
Cdd:COG0550 57 GKKKQVKELKKLAKKADEVILATDPDREGEAIAWHLLELLG----DKKPVKRVVFNEITKKAIKEAFKNPR--DIDMNLV 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 160 VSALARARADWLYGINMTRAYTILGRNAgydgvLSVGRVQTPVLGLVVRRDEEIEDFVAKDFFEVKAHIVTPADErFIAL 239
Cdd:COG0550 131 DAQQARRILDRLVGYNLSPLLWKKVKRG-----LSAGRVQSPALRLIVEREREIEAFVPEEYWTIEATFKTGGGE-FTAK 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 240 WqpsdscesYQDEEGRLLHRPLAEHVVNRITGQPAIVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQRL 319
Cdd:COG0550 205 L--------VKIDGKKILDEEEAEAILAALKGKTFTVTSVEKKPKKRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 320 YEThKLITYPRSDCRYLPEEHFAGRHSVLNAISihQADLLPlevmdSDRRNRCWDDKKVDAHHAIIPTA-RASKVNLTAD 398
Cdd:COG0550 277 YEV-GLITYMRTDSVRLSEDAVAAAREYIEALY--GKEYLP-----EKPRVYKTSKNAQEAHEAIRPTGvTRTPESLSGD 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 399 ESKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLG-SKERDEENEGAPLPVVEKGAELLCER 477
Cdd:COG0550 349 EFKLYDLIWKRFLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKVYGeGKDDEEEEEEKRLPPLKEGEKLKLKK 428
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 478 GEVVERQTQPPRPFTDASLLSAMtgiarfvqdKELkkvlratdGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRAL 557
Cdd:COG0550 429 IEPEQHFTKPPPRYTEASLVKAM---------EEL--------GIGRPSTYASIIETLQDRGYVEREGKRLVPTELGFIV 491
|
570 580 590 600
....*....|....*....|....*....|....*....|
gi 951133904 558 IHAL----PDIAArPDMTAHWESTLTQISEKNCRYQDFMQ 593
Cdd:COG0550 492 IDLLeehfPDLVD-YEFTAKMEEKLDEIAEGKLDWKDVLE 530
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
161-593 |
6.24e-132 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 393.53 E-value: 6.24e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 161 SALARARADWLYGINMTRAYTilgRNAGYDGVLSVGRVQTPVLGLVVRRDEEIEDFVAKDFFEVKAHIVTPADERFIALW 240
Cdd:pfam01131 9 AQLARRELDWLIGFNLSRLLT---LKLKGNKLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATLKDGGGVFANAKW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 241 qpsdscesyqdEEGRLLHRPLAEHVVNRITGQPAIVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQRLY 320
Cdd:pfam01131 86 -----------KRGRIFDKEEAEAILEKLKKGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 321 ETHKLITYPRSDCRYLPEEhfAGRHSVLNAISIHQADLLPL--EVMDSDRRNRCWDDKKVDAHHAIIPTARASKVN-LTA 397
Cdd:pfam01131 155 EKHGLITYPRTDSTYLSDD--ATLKAILEYLTKNYGKYLPYapRLLKKTKGKLTVGNAKVTAHEAIRPTGDIPVLPeLSD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 398 DESKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEgapLPVVEKGAELLCER 477
Cdd:pfam01131 233 DERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEKKEDEEE---LPELKEGEELKVTQ 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 478 GEVVERQTQPPRPFTDASLLSAMtgiarfvqDKElkkvlratdGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRAL 557
Cdd:pfam01131 310 VEVEEKKTKPPPRYTEASLIKAM--------EKA---------GIGTPATRATIIETLLERGYVERKKKSLVPTELGKAL 372
|
410 420 430
....*....|....*....|....*....|....*....
gi 951133904 558 IHAL---PDIAArPDMTAHWESTLTQISEKNCRYQDFMQ 593
Cdd:pfam01131 373 VEALekfPDLVD-PELTAELEEKLDEIAEGKLDWKDVLA 410
|
|
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
156-603 |
1.10e-122 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 368.86 E-value: 1.10e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 156 IPLCVSALARARADWLYGINMTRAYTILGRNagyDGVLSVGRVQTPVLGLVVRRDEEIEDFVAKDFFEVkahivtpader 235
Cdd:cd00186 1 ENLVNAQLARRILDRLVGFNLSRLLTKKLRR---KGVLSAGRVQSPTLGLIVEREREIKAFVPEDYWEI----------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 236 fialwqpsdscesyqdeegrllhrplaehvvnritgQPAIVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDI 315
Cdd:cd00186 67 ------------------------------------KEAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQI 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 316 CQRLYETHkLITYPRSDCRYLPEEHFAGRHSVLNAISIHQADLLPLEVmdsDRRNRCWDDKKVDAHHAIIPT----ARAS 391
Cdd:cd00186 111 AQKLYEAG-LITYPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLL---GRRNPKRGKKEQGAHEAIRPTkvapTPEL 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 392 KVNLTADESKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEEnegAPLPVVEKGA 471
Cdd:cd00186 187 EANLSEDEFKLYELIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKDDEE---EEPPPLKEGD 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 472 ELLCERGEVVERQTQPPRPFTDASLLSAMtgiarfvqDKElkkvlratdGLGTEATRAGIIELLFKRTFLFKKGRYIHAS 551
Cdd:cd00186 264 ELKLEEVELEEKETQPPPRYTEASLIKLM--------EKR---------GIGRPSTYASIIETLLDRGYVEKEKKKLIPT 326
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 951133904 552 PAGRALIHALPDIAAR---PDMTAHWESTLTQISEKNCRYQDFMQPLVATLQDLI 603
Cdd:cd00186 327 ELGFAVIELLEKHFPElvdPEFTAKLEEKLDEIAEGKKDYQEVLEEFYEEFKKIV 381
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
281-557 |
5.19e-89 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 277.21 E-value: 5.19e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 281 DKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQRLYEtHKLITYPRSDCRYLPEEHFAGrhsVLNAIS-IHQADLL 359
Cdd:smart00437 2 EKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYE-KGLITYPRTDSTRLSEEAVLE---ARNYIQkLYGKEYL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 360 PLEVMDSDRRNRCWDDKKVDAHHAIIPT----ARASKVNLTADESKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFI 435
Cdd:smart00437 78 DLAVVLLKPRKPRKGKKAQGAHEAIRPTkpifTPELEKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 436 AKARFLAEAGWRTLLGSKERDEENEgapLPVVEKGAELLCERGEVVERQTQPPRPFTDASLLSAMTgiarfvqdkelkkv 515
Cdd:smart00437 158 AKGKTLLFDGWLKVYPEEKKEEEIE---LPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLME-------------- 220
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 951133904 516 lraTDGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRAL 557
Cdd:smart00437 221 ---KRGIGRPSTYASIIETLLDRGYVTKKKKKLIPTELGIAV 259
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
1-640 |
0e+00 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 1127.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 1 MRLFIAEKPSLARAIADILPkPHRRGDGFIAcGSDQMVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWRLQPRPS 80
Cdd:PRK07726 1 MRLFIAEKPSVGRDIADVLK-PHKKGDGYIE-GNGYIVTWAIGHLLELAEPEAYDERYKRWRLEDLPIIPEKWKLVVKKK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 81 VSKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLDLatekRQNVRRCLINDLNPQAVERAVERLRYNREFIPLCV 160
Cdd:PRK07726 79 TAKQFNVVKKLLKQATEIVIATDADREGELIAREILDYCGV----RKPIKRLWISSLTDKAIKRAFANLKPGKETIPLYY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 161 SALARARADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIEDFVAKDFFEVKAHIVtpADERFIALW 240
Cdd:PRK07726 155 SALARSRADWLVGINMTRAYTLLGRKAGYNGVLSVGRVQTPTLALVVRRDEEIENFVPKPYWEVEAHLT--PGERFTAKW 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 241 QPSDSCEsyqDEEGRLLHRPLAEHVVNRITGQPAIVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQRLY 320
Cdd:PRK07726 233 QPSEPYQ---DEEGRLLDRPLAEQVVARIQGQPAKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKETLDIAQSLY 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 321 ETHKLITYPRSDCRYLPEEHFAGRHSVLNAIS-IHQADLLPLEVMDSDRRNRCWDDKKVDAHHAIIPTARASKVN-LTAD 398
Cdd:PRK07726 310 ETHKLITYPRTDSRYLPEDMVATLPEVLNAISkVDPYLLLAPPVLDPSIRSRAWNDKKVTAHHAIIPTEQPPNLSkLSED 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 399 ESKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEgAPLPVVEKGAELLCERG 478
Cdd:PRK07726 390 ERKVYDLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWKALLGKKEEDEEKE-QPLPVLAKGDELKVEKG 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 479 EVVERQTQPPRPFTDASLLSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRALI 558
Cdd:PRK07726 469 EVKEGQTQPPKRFTEGTLLSAMENIARFVQDKELKKTLKETDGLGTEATRAGIIEKLFKRGYLEKKGKYIHATDKGKQLI 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 559 HALPDIAARPDMTAHWESTLTQISEKNCRYQDFMQPLVATLQDLISQAKQNRSPQVFRGLPaAPSGATKKRKKTPSKAKE 638
Cdd:PRK07726 549 DALPEELTSPDMTAKWEQALDQISEGQLSYQDFMQPLKQWLKQLVEQAKQSSEKYKFDNLT-GPKCPDCGKPMLKVKGKN 627
|
..
gi 951133904 639 NK 640
Cdd:PRK07726 628 GK 629
|
|
| topB |
TIGR01056 |
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ... |
1-635 |
0e+00 |
|
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273419 [Multi-domain] Cd Length: 660 Bit Score: 946.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 1 MRLFIAEKPSLARAIADILPKPHRrGDGFIACGSDQMVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWRLQPRPS 80
Cdd:TIGR01056 1 MTLVLCEKPSQARDLATVLAKKKK-GNGYLEIGVGGFVTWAVGHLVELAEPEEYDEKYKNWRTYDLPLEPEDWQLVVSDK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 81 VSKQLNVIKQLL--QQADEVVHAGDPDREGQLLVDEVLDYLDLAteKRQNVRRCLINDLNPQAVERAVERLRYNREFIPL 158
Cdd:TIGR01056 80 TKKQFNVIKRILkeNKVDEVVIATDPDREGELIAREILDYLKVT--DKVTIKRLWISSLVDSSIRKAFKNLRPKSETEGL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 159 CVSALARARADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIEDFVAKDFFEVKAHIVTPAdERFIA 238
Cdd:TIGR01056 158 YKSGVARARADWLVGINLTRAFTKLGREAGNDGVLSVGRVQTPTLAMVVKRENEIKNFVGKPFYEVSATINKDE-QEFTT 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 239 LWQPsdscesYQDEEGRLLHRPLAEHVVNRITGQPAIVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQR 318
Cdd:TIGR01056 237 EWQP------YKDEEERELHEFLAENVVTDLTQKPALVTDIEKERKKTSAPLFYDLSALQEDANKRFGISAKRTLDIAQK 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 319 LYETHKLITYPRSDCRYLPEEHFAGRHSVLNAISIHQADLLPLEVMDSDRRNRCWDDKKVDAHHAIIPTARAS-KVNLTA 397
Cdd:TIGR01056 311 LYETHKLITYPRTDSRYLPEDEKEMLLEVLDALKVITPALLPIKKRDELTNNRLWNDKKIEDHHAIIPTGNDFnLSDLSE 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 398 DESKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGAPLPVVEKGAELLCER 477
Cdd:TIGR01056 391 EERNVYKLIAQNYLMQFMPKEEYETTTIEIAIGKLMFEAKGKILQDNGWKALLGKQEEDEETEDTTLPAFQKGDELDVET 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 478 GEVVERQTQPPRPFTDASLLSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRAL 557
Cdd:TIGR01056 471 LELLEKQTKPPARYTEGTLLSAMTNPAAFVQDKGLKKTLKETKGLGTEATRADIIENLFKRGFIQKKKNKIYITKNGKLL 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 558 IHALPDIAARPDMTAHWESTLTQISEKNCRYQDFMQPLVATLQDLISQAKqnRSPQVFRGLPAAP----SGATKKRKKTP 633
Cdd:TIGR01056 551 CLLLPELLTKPDLTAQWEQYLNGISAGEKDDDDFINTINEMIKQTINEEK--KNPETIQKVAKEPvscgGIAKCPAKDNG 628
|
..
gi 951133904 634 SK 635
Cdd:TIGR01056 629 RL 630
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
1-593 |
2.47e-152 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 450.70 E-value: 2.47e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 1 MRLFIAEKPSLARAIADILpkphrrGDGFIacgsdqmVTWCVGHLLEQAQPD-AYDsryarwslADLPIIPEkwrLQPRP 79
Cdd:COG0550 1 KKLVIVESPAKAKTIAKYL------GKDYV-------VTASVGHLRDLPKPElDVD--------VENDFEPK---YEVIP 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 80 SVSKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLDlateKRQNVRRCLINDLNPQAVERAVERLRynREFIPLC 159
Cdd:COG0550 57 GKKKQVKELKKLAKKADEVILATDPDREGEAIAWHLLELLG----DKKPVKRVVFNEITKKAIKEAFKNPR--DIDMNLV 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 160 VSALARARADWLYGINMTRAYTILGRNAgydgvLSVGRVQTPVLGLVVRRDEEIEDFVAKDFFEVKAHIVTPADErFIAL 239
Cdd:COG0550 131 DAQQARRILDRLVGYNLSPLLWKKVKRG-----LSAGRVQSPALRLIVEREREIEAFVPEEYWTIEATFKTGGGE-FTAK 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 240 WqpsdscesYQDEEGRLLHRPLAEHVVNRITGQPAIVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQRL 319
Cdd:COG0550 205 L--------VKIDGKKILDEEEAEAILAALKGKTFTVTSVEKKPKKRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 320 YEThKLITYPRSDCRYLPEEHFAGRHSVLNAISihQADLLPlevmdSDRRNRCWDDKKVDAHHAIIPTA-RASKVNLTAD 398
Cdd:COG0550 277 YEV-GLITYMRTDSVRLSEDAVAAAREYIEALY--GKEYLP-----EKPRVYKTSKNAQEAHEAIRPTGvTRTPESLSGD 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 399 ESKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLG-SKERDEENEGAPLPVVEKGAELLCER 477
Cdd:COG0550 349 EFKLYDLIWKRFLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKVYGeGKDDEEEEEEKRLPPLKEGEKLKLKK 428
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 478 GEVVERQTQPPRPFTDASLLSAMtgiarfvqdKELkkvlratdGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRAL 557
Cdd:COG0550 429 IEPEQHFTKPPPRYTEASLVKAM---------EEL--------GIGRPSTYASIIETLQDRGYVEREGKRLVPTELGFIV 491
|
570 580 590 600
....*....|....*....|....*....|....*....|
gi 951133904 558 IHAL----PDIAArPDMTAHWESTLTQISEKNCRYQDFMQ 593
Cdd:COG0550 492 IDLLeehfPDLVD-YEFTAKMEEKLDEIAEGKLDWKDVLE 530
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
161-593 |
6.24e-132 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 393.53 E-value: 6.24e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 161 SALARARADWLYGINMTRAYTilgRNAGYDGVLSVGRVQTPVLGLVVRRDEEIEDFVAKDFFEVKAHIVTPADERFIALW 240
Cdd:pfam01131 9 AQLARRELDWLIGFNLSRLLT---LKLKGNKLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATLKDGGGVFANAKW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 241 qpsdscesyqdEEGRLLHRPLAEHVVNRITGQPAIVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQRLY 320
Cdd:pfam01131 86 -----------KRGRIFDKEEAEAILEKLKKGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 321 ETHKLITYPRSDCRYLPEEhfAGRHSVLNAISIHQADLLPL--EVMDSDRRNRCWDDKKVDAHHAIIPTARASKVN-LTA 397
Cdd:pfam01131 155 EKHGLITYPRTDSTYLSDD--ATLKAILEYLTKNYGKYLPYapRLLKKTKGKLTVGNAKVTAHEAIRPTGDIPVLPeLSD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 398 DESKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEgapLPVVEKGAELLCER 477
Cdd:pfam01131 233 DERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEKKEDEEE---LPELKEGEELKVTQ 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 478 GEVVERQTQPPRPFTDASLLSAMtgiarfvqDKElkkvlratdGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRAL 557
Cdd:pfam01131 310 VEVEEKKTKPPPRYTEASLIKAM--------EKA---------GIGTPATRATIIETLLERGYVERKKKSLVPTELGKAL 372
|
410 420 430
....*....|....*....|....*....|....*....
gi 951133904 558 IHAL---PDIAArPDMTAHWESTLTQISEKNCRYQDFMQ 593
Cdd:pfam01131 373 VEALekfPDLVD-PELTAELEEKLDEIAEGKLDWKDVLA 410
|
|
| PRK08173 |
PRK08173 |
DNA topoisomerase III; Validated |
3-611 |
1.89e-129 |
|
DNA topoisomerase III; Validated
Pssm-ID: 236172 [Multi-domain] Cd Length: 862 Bit Score: 401.74 E-value: 1.89e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 3 LFIAEKPSLARAIADILPKPHRRGDGFiacGSDQMV-TWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWRLQPRPSV 81
Cdd:PRK08173 5 LIIAEKPSVANDIARALGGFTKHDEYF---ESDEYVlSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 82 SKQLNVIKQLLQQAD--EVVHAGDPDREGQLLVDEVLDYldlaTEKRQNVRRCLINDLNPQAVERAVERLRYNREFIPLC 159
Cdd:PRK08173 82 ESRLKVLTKLIKRKDvtRLINACDAGREGELIFRLIAQH----AKAKKPVKRLWLQSMTPQAIRDGFANLRSDEDMQPLA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 160 VSALARARADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIEDFVAKDFFEVKAHIVTPA------- 232
Cdd:PRK08173 158 DAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVRAEFVAAAgfyegrw 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 233 -DERFialwqPSDSCESYQDEEgRLLHRPLAEHVVNRITGQPAIVTSyNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQ 311
Cdd:PRK08173 238 fDPKF-----KKDEFDPEKRAS-RLWSEAAAEAIVAACRGKPGTVTE-ESKPSTQLSPLLFDLTSLQREANGRFGFSAKN 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 312 VLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHSVLNAISiHQADLLPL--EVMDSD--RRN-RCWDDKKVDAHHAIIP 386
Cdd:PRK08173 311 TLGLAQALYEKHKVLTYPRTDSRALPEDYLGTVKQTLEMLK-ESNNYLPHakQILDKGwvKPNkRIFDNSKISDHFAIIP 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 387 TARASKvNLTADESKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGskeRDEENEGAPLPV 466
Cdd:PRK08173 390 TLQAPK-SLSEPEQKLYDLVVKRFLAVFFPAAEFLVTTRITEVAGHHFKTEGKVLVNPGWLAVYG---KEAQGADANLVP 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 467 VEKGAELLCERGEVVERQTQPPRPFTDASLLSAMTGIARFVQDKELKKVLrATDGLGTEATRAGIIELLFKRTFLFKKGR 546
Cdd:PRK08173 466 VQKGEKVKTDKIEAVALTTKPPARYNEATLLSAMEGAGKLVEDDELREAM-AEKGLGTPATRAAIIEGLLGEKYLVREGR 544
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 951133904 547 YIHasPAGRA-----LIHALpDIAA--RPDMTAHWESTLTQISEKNCRYQDFMQPLVATLQDLISQAKQNRS 611
Cdd:PRK08173 545 ELI--PTAKAfqlmtLLRGL-GVEEltSPELTGEWEYKLSQIERGKLSRDAFMQEIAQMTQQIVKRAKEYDS 613
|
|
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
156-603 |
1.10e-122 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 368.86 E-value: 1.10e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 156 IPLCVSALARARADWLYGINMTRAYTILGRNagyDGVLSVGRVQTPVLGLVVRRDEEIEDFVAKDFFEVkahivtpader 235
Cdd:cd00186 1 ENLVNAQLARRILDRLVGFNLSRLLTKKLRR---KGVLSAGRVQSPTLGLIVEREREIKAFVPEDYWEI----------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 236 fialwqpsdscesyqdeegrllhrplaehvvnritgQPAIVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDI 315
Cdd:cd00186 67 ------------------------------------KEAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQI 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 316 CQRLYETHkLITYPRSDCRYLPEEHFAGRHSVLNAISIHQADLLPLEVmdsDRRNRCWDDKKVDAHHAIIPT----ARAS 391
Cdd:cd00186 111 AQKLYEAG-LITYPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLL---GRRNPKRGKKEQGAHEAIRPTkvapTPEL 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 392 KVNLTADESKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEEnegAPLPVVEKGA 471
Cdd:cd00186 187 EANLSEDEFKLYELIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKDDEE---EEPPPLKEGD 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 472 ELLCERGEVVERQTQPPRPFTDASLLSAMtgiarfvqDKElkkvlratdGLGTEATRAGIIELLFKRTFLFKKGRYIHAS 551
Cdd:cd00186 264 ELKLEEVELEEKETQPPPRYTEASLIKLM--------EKR---------GIGRPSTYASIIETLLDRGYVEKEKKKLIPT 326
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 951133904 552 PAGRALIHALPDIAAR---PDMTAHWESTLTQISEKNCRYQDFMQPLVATLQDLI 603
Cdd:cd00186 327 ELGFAVIELLEKHFPElvdPEFTAKLEEKLDEIAEGKKDYQEVLEEFYEEFKKIV 381
|
|
| PRK14724 |
PRK14724 |
DNA topoisomerase III; Provisional |
3-608 |
7.59e-103 |
|
DNA topoisomerase III; Provisional
Pssm-ID: 237803 [Multi-domain] Cd Length: 987 Bit Score: 335.00 E-value: 7.59e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 3 LFIAEKPSLA----RAIADILPKPHRRGDGFIAcgSDQMVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWRLQPR 78
Cdd:PRK14724 4 LVIAEKPSVAqdivRALTPVAGKFEKHDEHFES--DSYVVTSAVGHLVEIQAPEEFDVKRGKWSFANLPVIPPYFDLKPV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 79 PSVSKQLNVIKQLLQQAD--EVVHAGDPDREGQLLVDEVLDYLDLATEKRQN-VRRCLINDLNPQAVERAVERLRYNREF 155
Cdd:PRK14724 82 DKTKTRLNAVVKLAKRKDvtELVNACDAGREGELIFRLIEQYAGGAKGGLGKpVKRLWLQSMTPQAIRDGFDNLRSDAQM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 156 IPLCVSALARARADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIEDFVAKDFFEVKAHIVTPADEr 235
Cdd:PRK14724 162 QGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEIHAGFHAEAGE- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 236 FIALW------QPSDSCESYQDeegRLLHRPLAEHVVNRITGQPAIVTSyNDKRESETAPLPFSLSTLQIEAAKRFGLSA 309
Cdd:PRK14724 241 YLGKWfdpqwkKASDDPEARAD---RVWSEREARAIADAVRGKAATVTE-ESKPTTQASPLLFDLTSLQREANGKFGFSA 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 310 QQVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHSVLNAISI----HQADLLPLEVMDSDRR--NRCWDDKKVDAHHA 383
Cdd:PRK14724 317 KTTLALAQSLYERHKALTYPRTDSRALPEDYLPVAKQTFEMLATsgmrHLAPFAQQALDGNYVRpsKRIFDNSKVSDHFA 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 384 IIPTARASKvNLTADESKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENE--- 460
Cdd:PRK14724 397 IIPTTQAPS-GLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISQVVGHSFKTEGKVLVKPGWLAIYGKEAANEVEDakd 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 461 ---GAPLPVVEKGAELLCERGEVVERQTQPPRPFTDASLLSAMTGIARFVQDKELKKVLRATdGLGTEATRAGIIELLFK 537
Cdd:PRK14724 476 gdkGQPLVPVKPGEMVRTEFAEAKGLKTKPPARYSEATLLGAMESAGKQIDDDELREAMQEK-GLGTPATRAAIIEGLLT 554
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 951133904 538 RTFLFKKGRYIHASPAGRALIHALPDIA----ARPDMTAHWESTLTQISEKNCRYQDFMQPLVATLQDLISQAKQ 608
Cdd:PRK14724 555 EKYMLREGRELIPTAKAFQLMTLLRGLGveelSRAELTGEWEYKLAQMEKGQLSREAFMQQIAAMTEKLVKKAKE 629
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
281-557 |
5.19e-89 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 277.21 E-value: 5.19e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 281 DKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQRLYEtHKLITYPRSDCRYLPEEHFAGrhsVLNAIS-IHQADLL 359
Cdd:smart00437 2 EKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYE-KGLITYPRTDSTRLSEEAVLE---ARNYIQkLYGKEYL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 360 PLEVMDSDRRNRCWDDKKVDAHHAIIPT----ARASKVNLTADESKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFI 435
Cdd:smart00437 78 DLAVVLLKPRKPRKGKKAQGAHEAIRPTkpifTPELEKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 436 AKARFLAEAGWRTLLGSKERDEENEgapLPVVEKGAELLCERGEVVERQTQPPRPFTDASLLSAMTgiarfvqdkelkkv 515
Cdd:smart00437 158 AKGKTLLFDGWLKVYPEEKKEEEIE---LPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLME-------------- 220
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 951133904 516 lraTDGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRAL 557
Cdd:smart00437 221 ---KRGIGRPSTYASIIETLLDRGYVTKKKKKLIPTELGIAV 259
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
1-611 |
2.02e-85 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 284.59 E-value: 2.02e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 1 MRLFIAEKPSLARAIADIL----PKPHRRGD----GFIACGSDQMVTWCVGHLLEQAQPdaydSRYARWSLADLPIIPEK 72
Cdd:PRK07219 1 TELIIAEKNNAARRIADILsggkAKKKRVNGvpyyEFERKGEKWIVIGLSGHIVTVDFP----EEYGDWRDVDPAELIDA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 73 wRLQPRPSVSKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLDLATEKrqNVRRCLINDLNPQAVERAVERL--- 149
Cdd:PRK07219 77 -DPVKKITKQNYINALKKLAKDADEIIIATDYDREGELIGKEAYHILREVCQV--PVKRARFSSLTKKEIRKAFENPdei 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 150 RYNrefipLCVSALARARADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIEDFVAKDFFEVKAHIV 229
Cdd:PRK07219 154 DFN-----LADAGEARQIIDLYWGAALTRFLSLSVRQLGRWDFLSVGRVQTPTLAFIVDREREIRAFDPEDYWKIEALLD 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 230 TPAderfialwQPSDSCESYQDEEGRLLHRPLAEHVVNRITGQ-PAIVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLS 308
Cdd:PRK07219 229 KEA--------QYFYRDLIGGHEAEKFWDEEEAEEIYEKLKGAkEATVSSVKKRERTISPPAPFNTTEFLREASKIFGIS 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 309 AQQVLDICQRLYeTHKLITYPRSDCRYLPEEHfaGRHSVLNAISIHQ-----ADLLplevMDSDRRNRCWDDKKVDAHHA 383
Cdd:PRK07219 301 PKRAMEIAEKLY-TAGYISYPRTDNTVYPDDL--DPKELLKKLSKKKeygpyAESI----LEQENIKPTEGKKETTDHPP 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 384 IIPTARASKVNLTADESKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENegap 463
Cdd:PRK07219 374 IHPVDVPKREELSDDEWKVYELIVRRFLATLADPAEWEYLKVELDVNGEIFKASGSRLVEEGWHEVYPYEKFDEKE---- 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 464 LPVVEKGAELLCERGEVVERQTQPPRPFTDASLLsamtgiarfvqdKELKKVlratdGLGTEATRAGIIELLFKRTFlFK 543
Cdd:PRK07219 450 LPDLEEGEKLKVNKIEIEAKETQPPKRYTQSSLI------------KEMEKR-----GLGTKATRHDIIEKLYKRGY-VI 511
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 951133904 544 KGRYIHASPAGRALIHAL----PDIaARPDMTAHWESTLTQISEKNCRYQDFMQPLVATLQDLISQAKQNRS 611
Cdd:PRK07219 512 EGDPPRPTDLGIAVIEALekyaPEI-VSEEMTAQLEADMQAIEDGKKKKEDVTEESREMLKEILSELKEKRK 582
|
|
| PRK05776 |
PRK05776 |
DNA topoisomerase I; Provisional |
3-581 |
6.56e-64 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 235602 [Multi-domain] Cd Length: 670 Bit Score: 223.33 E-value: 6.56e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 3 LFIAEKPSLARAIADILpkphrrGDGFIAC-------------GSDQMVTWCVGHLLeQAQPDA-----YDsryARWsla 64
Cdd:PRK05776 4 LVIAEKPKAARKIAEAL------SEKPIRCriygvpywivkrdGKKIVVAPAAGHLF-GLHTKSkgfpvFD---YEW--- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 65 dlpiIPeKWRLQPRPSVSKQ-LNVIKQLLQQADEVVHAGDPDREGqllvdEVLDYL---DLATEKRqnVRRCLINDLNPQ 140
Cdd:PRK05776 71 ----KP-LYEIDKGSKYTKKyYELLSSLSKYADEFINACDYDIEG-----SVIGYLiikYLGDPKK--AKRMKFSALTKS 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 141 AVERA---VERLRYNrefipLCVSALARARADWLYGINMTRAYTILGRNA-GYDGVLSVGRVQTPVLGLVVRRDEEIEDF 216
Cdd:PRK05776 139 DIRRAfrnLETLDYE-----MINAGIARHELDWLWGINVSRALMSSVRDAsGKRVILSAGRVQSPTLKYVVEREIERNLF 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 217 VAKDFFEVKAhIVTPADERFIAlwQPSDSCESYQDEegrllhrplAEHVVNRITGQP-AIVTSYNDKRESETAPLPFSLS 295
Cdd:PRK05776 214 VPLPYFSVSI-IIEKNGYEFTL--KYENKKFETKEE---------AKEILEEIKKTGyLKVTKVEVKIEILEPPPPFNLG 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 296 TLQIEAAKRFGLSAQQVLDICQRLYEtHKLITYPRSDCRYLPEE-HFAgrhSVLNAISiHQADLLPL--EVMDSDR-RNR 371
Cdd:PRK05776 282 DLQVEAARIYGFSPYKTQSIAEDLYL-DGLISYPRTNSQKLPPTlNIR---NILKGLS-RSPQYRPLvnLLLKETKgVLK 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 372 CWDDKKVD-AHHAIIPTARASKvNLTADESKVYRLVAQQYLMQFCPDAQFRKCVIELDIAG--GKFIAKARFLAEAGWRT 448
Cdd:PRK05776 357 PVQGPKDDpAHPAIYPTGEPPK-NLSKDEFKLYDLIVRRFLASFAAPAVLSNTIVTLRVPGfpLVFSASGQRIEERGWLK 435
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 449 LLGSKERDEEnegaPLPVVEKGAELLCERGEVVERQTQPPRPFTDASLLSAMtgiarfvqdkelkkvlrATDGLGTEATR 528
Cdd:PRK05776 436 YYPFHKFDEE----ELPLLKKGERVKIVDVKVRKSYTKPPSRYSKASLLKWM-----------------ESVGIGTEATR 494
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*..
gi 951133904 529 AGIIELLFKRTFLFKKGRYIHASPAGRALIHAL----PDIAArPDMTAHWESTLTQI 581
Cdd:PRK05776 495 ARIIETLFKRGYLTSNGKYIEVTPLGFGVAEVLekyfPDIVS-VELTRDFEEKLEMI 550
|
|
| PRK07220 |
PRK07220 |
DNA topoisomerase I; Validated |
1-610 |
3.94e-61 |
|
DNA topoisomerase I; Validated
Pssm-ID: 180892 [Multi-domain] Cd Length: 740 Bit Score: 216.93 E-value: 3.94e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 1 MRLFIAEKPSLARAIADIL-PKP--HRRGDG-----FIACGSDQMVTWCVGHLLEQAQPDAYDSryarWSLADlpiiPEK 72
Cdd:PRK07220 1 MHLIITEKNIAARRIAQILaPKKpkKTRVSGvdvyrYEDNGDDTVVVGLSGHIVNIDFPKEYNN----WQKVD----ARD 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 73 W---RLQPRPSVSKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLDLATEKRQnVRRCLINDLNPQAVERAVErl 149
Cdd:PRK07220 73 LidaEIITTPTQKKIVTALKKLGKEADRVTIATDYDREGELIGVEALNIIKKVNPDIK-FDRVRYSAITKKEIERAFS-- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 150 ryNREFIP--LCVSALARARADWLYGINMTRAYTILGRNAGyDGVLSVGRVQTPVLGLVVRRDEEIEDFVAKDFFEVKAH 227
Cdd:PRK07220 150 --NPVEVDfnLADAGHSRQVIDLVWGAALTRYISLAAGRLG-KMFLSVGRVQSPTLALIVDREKEREAFVPTPYWEIYAT 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 228 IvTPADERFIAlwqpsdscesyQDEEGRLLHRPLAEHVVNRItGQPAIVTSYNDKRESETAPLPFSlSTLQIEAAKRFGL 307
Cdd:PRK07220 227 L-ENNGETFVA-----------QHSTRRFWEKEEADRVFEKL-GKTAEVTEVEKGTKTDKPPTPFN-TTEFISAANSIGF 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 308 SAQQVLDICQRLYeTHKLITYPRSDCRYLPE--------EHFAGRHSVLNAISI-HQADLLPlevmdsdRRNRcwddKKV 378
Cdd:PRK07220 293 SAANAMRIAESLY-TNGYISYPRTDNTVYPEsldlreqiEIFAEGPFGEYAQKLlEKGELVP-------TRGK----KET 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 379 DAHHAIIPTARASKVNLTADESKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLG-SKERDE 457
Cdd:PRK07220 361 TDHPPIYPASLAKKSELKEDEWKVYELVVRRFFATFAGPAEWETMKLRFDIGGEEFRANGSRLTEPGWRWYYPyNAPEDR 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 458 EnegapLPVVEKGAELLCERGEVVERQTQPPRPFTDASLLSAMtgiarfvqdKELkkvlratdGLGTEATRAGIIELLFK 537
Cdd:PRK07220 441 L-----LPELSEGEELKVKKKEMLDKETQPPGRYGQGRLIKLM---------EDL--------GLGTKATRHEIISKLYS 498
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 538 RTflfkkgrYIHASP-----AGRALIHALPDIA---ARPDMTAHWESTLTQISEKNCRYQDFMQPLVATLQDLISQAKQN 609
Cdd:PRK07220 499 RA-------YIHGNPiqptnTAFAVVDALEKYAptiTKPDMTSRLEEDMDKIAEGKIKEDAVLEESREMLEQVFDELDKN 571
|
.
gi 951133904 610 R 610
Cdd:PRK07220 572 R 572
|
|
| PRK14973 |
PRK14973 |
DNA topoisomerase I; Provisional |
1-585 |
5.17e-52 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 184936 [Multi-domain] Cd Length: 936 Bit Score: 193.14 E-value: 5.17e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 1 MRLFIAEKPSLARAIADILP---KPHRRGDGFIACGS--DQMVTWCVGHLLEQAqpdaYDSRYARW--------SLADLP 67
Cdd:PRK14973 1 MHLIIAEKNIAANRIAQILAgktKVQVKKDGGVSTYSfdDTVVVGLRGHVVEVD----FEPGYTNWrseehtprSLIDAD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 68 IIPekwrlqpRPSVSKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDyLDLATEKRQNVRRCLINDLNPQAVERAVE 147
Cdd:PRK14973 77 TIK-------KPTEKKIVGLIQKLAKKADRVTIATDFDTEGELIGKEAYE-LVRAVNPKVPIDRARFSAITKEEIVTAFA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 148 RLRyNREFiPLCVSALARARADWLYGINMTRAYTILGRNAGyDGVLSVGRVQTPVLGLVVRRDEEIEDFVAKDFFEVKah 227
Cdd:PRK14973 149 EPT-DLDF-ALAAAGEARQIIDLIWGASLTRFISLAAHRGG-DNILSVGRVQSPTLAMIVDREKEIEAFVPEKYWMLS-- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 228 IVTPAD-ERFIAlwqpsdscesyQDEEGRLLHRPLAEHVVNRiTGQPAIVTSYNDKRESETAPLPFSLSTLqIEAAKRFG 306
Cdd:PRK14973 224 LATEKDgEGIEA-----------RHTHGRFTDSAAAEAAYDA-TKEPLVVTEVKEGHKVDRAPTPFDTTTF-IVAASRLG 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 307 LSAQQVLDICQRLYeTHKLITYPRSDCRYLPEEhfAGRHSVLNAISIHQADLLPLEVMDSDRRNRCWDDKKVDAHHAIIP 386
Cdd:PRK14973 291 FSAANAMRIAEDLY-MNGYISYPRTDNTIYPKS--LDLNGVLATLAKGAFSKDVAWVKDNRRPVPTRGKKSSTDHPPIHP 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 387 TARASKVNLTADESKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEEnegaPLPV 466
Cdd:PRK14973 368 TGVATREELGDDRWKLYELVVRRFLATLSPDAEWATMKVNFDAGGEPYTATGGRLLEAGWRTVYPYSEAKEN----ILPA 443
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 467 VEKGAELLCERGEVVERQTQPPRPFTDASLLSAMtgiarfvqdKELkkvlratdGLGTEATRAGIIELLFKRtflfkkgR 546
Cdd:PRK14973 444 FALGEKLPILAVNLEEKETQPPARYSQSRLIQRM---------EEL--------GLGTKSTRHEVIGKLVSR-------K 499
|
570 580 590 600
....*....|....*....|....*....|....*....|....*..
gi 951133904 547 YIHASP-----AGRALIHALPDIAA---RPDMTAHWESTLTQISEKN 585
Cdd:PRK14973 500 YIEGNPlrptlVGRAVTESLEEHAGtitEPDMTQTLEEHMQQIKERK 546
|
|
| TOPRIM_TopoIA_TopoIII |
cd03362 |
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type ... |
1-149 |
6.34e-52 |
|
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173782 [Multi-domain] Cd Length: 151 Bit Score: 175.88 E-value: 6.34e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 1 MRLFIAEKPSLARAIADILPKPHRRGDGFIAC-----GSDQMVTWCVGHLLEQAQPDAYDSRYARWSLADlPIIPEKWRL 75
Cdd:cd03362 1 MVLIIAEKPSVAKAIAKILGGGSKKKGKGRYYefygeGGGYVVTWASGHLLELDFPEEYDPWDKVWPLED-PLFPAPFKL 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 951133904 76 QPRPSVSKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLDLATEKRqnVRRCLINDLNPQAVERAVERL 149
Cdd:cd03362 80 KVDKGKKKQFKVLKKLAKRADEIVIATDADREGELIGREILEYAKCVKRKP--VKRAWFSSLTPKAIRRAFKNL 151
|
|
| TOPRIM_TopoIA |
cd01028 |
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
1-149 |
1.00e-43 |
|
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli topisomerases I and III, eukaryotic topoisomerase III and, ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA. These enzymes cleave one strand of the DNA duplex, covalently link to the 5' phosphoryl end of the DNA break and allow the other strand of the duplex to pass through the gap. Reverse gyrase is also able to insert positive supercoils in the presence of ATP and negative supercoils in the presence of AMPPNP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173778 [Multi-domain] Cd Length: 142 Bit Score: 153.15 E-value: 1.00e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 1 MRLFIAEKPSLARAIADILPKPHRRgDGFIACGSDQMVTWCVGHLLEQAQPDAYDSRYARWSLadlPIIPEKWRLQPRPS 80
Cdd:cd01028 1 KVLIIAEKPSKAKTIAKILGKGSKK-KGFYGEGGGYVVTASVGHLLELPFPEEYVDWDKDWPL---ELFPFEPKYVVIPD 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 951133904 81 VSKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLDlatEKRQNVRRCLINDLNPQAVERAVERL 149
Cdd:cd01028 77 KKKQLKALKKLAKKADEIVLATDPDREGELIAWEILEVLK---CDNKPVKRAWFSEITPKAIREAFKNL 142
|
|
| PRK06599 |
PRK06599 |
DNA topoisomerase I; Validated |
1-609 |
3.24e-41 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235840 [Multi-domain] Cd Length: 675 Bit Score: 159.25 E-value: 3.24e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 1 MRLFIAEKPSLARAIADILpkphrrgdgfiacGSDQMVTWCVGHLleqaqpdaydsryarwslADLP------------- 67
Cdd:PRK06599 3 KKLVIVESPAKAKTIKKYL-------------GKDYKVLASFGHV------------------RDLPkkkggvdpdndfa 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 68 ----IIPEKwrlqprpsvSKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLDLATEKRQNVRRCLINDLNPQAVE 143
Cdd:PRK06599 52 pkyeIIEGK---------EKVVDALKKAAKKADAVYLATDPDREGEAIAWHIAEVLKEAKLKDKNVKRVVFNEITKKAVQ 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 144 RAVERLR---YNrefipLCVSALARARADWLYGinmtraYTI-------LGRNagydgvLSVGRVQTPVLGLVVRRDEEI 213
Cdd:PRK06599 123 EAIENPRdidMD-----LVDAQQARRALDYLVG------FKLspllwkkVRRG------LSAGRVQSVALRLICEREDEI 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 214 EDFVAKDFFEVKAHIVTPADERFIA-LWQPSD---SCESYQDEEgrllhrpLAEHVVNRITGQPAIVTSYNDKRESETAP 289
Cdd:PRK06599 186 EAFIPQEYWTIEADLATSNGEPFTAkLVEVNGkklEKFSITNEE-------QAKALVKALEGQAYTVDKIEKKERKRNPP 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 290 LPFSLSTLQIEAAKRFGLSAQQVLDICQRLYE-------THKLITYPRSDCRYLPEEHFAGRHSVlnaisIHQA---DLL 359
Cdd:PRK06599 259 PPFITSTLQQEASRKLGFSAKKTMRIAQKLYEgidlgegTVGLITYMRTDSVRLSNEALDEARKY-----ITKKygkEYL 333
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 360 PlevmDSDRRNRcwddKKV----DAHHAIIPTA-----RASKVNLTADESKVYRLVAQQYLM-QFCPdAQFRKCVIELDI 429
Cdd:PRK06599 334 P----AKPRVYK----KKSknaqEAHEAIRPTSinrtpESLKPYLTPDQFKLYELIWKRTVAsQMAP-AILDQTSVDIAS 404
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 430 AGGKFIAKA-----RFlaeAGWRTLLG-SKERDEENEGAPLPVVEKGAELLCErgEVVERQ--TQPPRPFTDASLLsamt 501
Cdd:PRK06599 405 ENGKYVFRAtgsviLF---PGFLKVYGeSKDDEEEDDEKLLPPLKEGEKLKLD--ELLPEQhfTEPPPRYSEASLV---- 475
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 502 giarfvqdKELKKVlratdGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRA----LIHALPDIAARpDMTAHWEST 577
Cdd:PRK06599 476 --------KKLEEY-----GIGRPSTYASIISTLQDREYVELEKKRFIPTDLGRIvndfLVEHFPKYVDY-DFTAGLEDE 541
|
650 660 670
....*....|....*....|....*....|..
gi 951133904 578 LTQISEKNCRYQDFMQPLVATLQDLISQAKQN 609
Cdd:PRK06599 542 LDEIAEGKKDWKPVLREFWEPFISNLEKVEED 573
|
|
| PRK07561 |
PRK07561 |
DNA topoisomerase I subunit omega; Validated |
1-592 |
1.39e-39 |
|
DNA topoisomerase I subunit omega; Validated
Pssm-ID: 236048 [Multi-domain] Cd Length: 859 Bit Score: 155.72 E-value: 1.39e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 1 MRLFIAEKPSLARAIADILPKphrrgdGFIacgsdqmVTWCVGHL---------LEQAQPDAYDSR-----YARWSlADL 66
Cdd:PRK07561 2 KSLVIVESPAKAKTINKYLGS------DYV-------VKASVGHIrdlptsassVPAKEKGALWARmgvdpDHDFE-ALY 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 67 PIIPEKwrlqprpsvSKQLNVIKQLLQQADEVVHAGDPDREGQ-----LLvdEVLDyldlatEKRQNVRRCLINDLNPQA 141
Cdd:PRK07561 68 EVLPGK---------EKVVSELKKAAKDADELYLATDPDREGEaiawhLL--EVLG------GDDVPVKRVVFNEITKNA 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 142 VERAVERLR---YNRefiplcVSA-LARaRA-DWLYGinmtraYTI-------LGRNagydgvLSVGRVQTPVLGLVVRR 209
Cdd:PRK07561 131 IQEAFENPReldINL------VNAqQAR-RFlDRLVG------YMVspllwkkIARG------LSAGRVQSVAVRLIVER 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 210 DEEIEDFVAKDFFEVKAHIVTPADERFIA-LWQpsdscesYQDEE---GRLLHRPLAEHVVNRITGQPAIVTSYNDKRES 285
Cdd:PRK07561 192 EREIEAFVPEEYWDIHADLTTPRGDAFEArLTH-------LDGKKfapVDLLNEAQAEAAVAALEGARYSVASVEDKPTT 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 286 ETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQRLYEThKLITYPRSDCRYLPEEhfagrhsvlnAIS-----IHQ---AD 357
Cdd:PRK07561 265 RKPSAPFTTSTLQQEASRKLGFSVKKTMRIAQRLYEA-GYITYMRTDSTNLSQE----------AINaargyIGDnygKK 333
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 358 LLPlevmDSDRRNrcwdDKKV----DAHHAIIPT---ARASKVN-LTADESKVYRL-----VAQQylMqfcPDAQFRKcv 424
Cdd:PRK07561 334 YLP----EKPRQY----SSKAknaqEAHEAIRPSdvfRTPDQLKgLEGDAQRLYELiwkrfVASQ--M---APARYDS-- 398
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 425 IELDIAGG--KFIAKARFLAEAGWRTLL--GSKErDEENEGAPLPVVEKGAELLCERGEVVERQTQPPRPFTDASLLsam 500
Cdd:PRK07561 399 TTVTIAAGdaELRATGRVLRFDGFLKVYveGRDD-ALDDEDRRLPALKVGDALTLEKLDPTQHFTKPPARYSEASLV--- 474
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 501 tgiarfvqdKELKKvlratDGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRALIHAL----PDIAArPDMTAHWES 576
Cdd:PRK07561 475 ---------KELEK-----LGIGRPSTYASIISTIQDRGYVRLENRRFYPEKMGRIVTDRLeeffPRLVD-YDFTARMEE 539
|
650
....*....|....*.
gi 951133904 577 TLTQISEKNCRYQDFM 592
Cdd:PRK07561 540 ELDDIANGEADWKPVL 555
|
|
| PRK08780 |
PRK08780 |
DNA topoisomerase I; Provisional |
82-613 |
4.41e-35 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 181555 [Multi-domain] Cd Length: 780 Bit Score: 141.82 E-value: 4.41e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 82 SKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYL-DLATEKRQNVRRCLINDLNPQAVERAVERLRynREFIPLCV 160
Cdd:PRK08780 61 EKHVEAIAKAAKSADDLYLATDPDREGEAISWHLAEILkERGLLKDKPMQRVVFTEITPRAIKEAMAKPR--DIASDLVD 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 161 SALARARADWLYGINMTrayTILGR--NAGydgvLSVGRVQTPVLGLVVRRDEEIEDFVAKDFFEVKAHIVTPAdERFIA 238
Cdd:PRK08780 139 AQQARRALDYLVGFNLS---PLLWRkiQRG----LSAGRVQSPALRMIVEREEEIEAFIAREYWSIEADCAHPS-QPFNA 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 239 LWQPSDSCESYQ----DEEgrllhrpLAEHVVNRIT----GQPAIVTSYNDKRESETAPlPFSLSTLQIEAAKRFGLSAQ 310
Cdd:PRK08780 211 KLIKLDGQKFEQftitDGD-------TAEAARLRIQqaaqGTLHVTDVESKERKRNPAP-PFTTSTLQQEASRKLGFTTR 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 311 QVLDICQRLYE--------THKLITYPRSDCRYLPEEHFAgrhSVLNAISIH-QADLLPlevmDSDRRNRCWDDKKVDAH 381
Cdd:PRK08780 283 RTMQVAQKLYEgvdlgdegSVGLITYMRTDSVNLSQDALA---EIRDVIARDyGTASLP----DQPNTYKTKSKNAQEAH 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 382 HAIIPTA-----RASKVNLTADESKVYRLVAQQYLM-QFCPdAQFRKCVIELDI-------AGGKFIAKARFLAEagWRT 448
Cdd:PRK08780 356 EAVRPTSalrtpAQVARFLSDDQRRLYELIWKRAVAcQMIP-ATLNTVSVDLAAgsehvfrATGSTVVVPGFLAV--YEE 432
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 449 LLGSKERDEENEGAPLPVVEKGAELLCERGEVVERQTQPPRPFTDASLLSAMtgiarfvqdKELkkvlratdGLGTEATR 528
Cdd:PRK08780 433 GKDDKSAEDEDEGRKLPPMKEGDNVPLERIRAEQHFTEPPPRYTEASLVKAL---------EEY--------GIGRPSTY 495
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 529 AGIIELLFKRTFLFKKGRYIHASPAGRALIHALPDIAARP---DMTAHWESTLTQISEKNCRYQDFMQPLVATLQDLISQ 605
Cdd:PRK08780 496 ASIISTLQFRKYVEMEGRRFRPTDVGRAVNKFLTGHFTRYvdyDFTARLEDDLDAVSRGEKEWIPLMEKFWGPFKELVEE 575
|
....*...
gi 951133904 606 AKQNRSPQ 613
Cdd:PRK08780 576 KKDSVDRT 583
|
|
| PRK06319 |
PRK06319 |
DNA topoisomerase I/SWI domain fusion protein; Validated |
76-555 |
7.92e-34 |
|
DNA topoisomerase I/SWI domain fusion protein; Validated
Pssm-ID: 235778 [Multi-domain] Cd Length: 860 Bit Score: 138.03 E-value: 7.92e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 76 QPRPSVSKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLdlatEKRQNVRRCLINDLNPQAVeraVERLRYNREF 155
Cdd:PRK06319 55 QILPDKEEVINKICKLAKKCDVVYLSPDPDREGEAIAWHIANQL----PKNTKIQRISFNAITKGAV---TEALKHPREI 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 156 -IPLCVSALARARADWLYGINMTrayTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIEDFVAKDFFEVKAHIVTPADE 234
Cdd:PRK06319 128 dMALVNAQQARRLLDRIVGYKIS---PILSRKLQRRSGVSAGRVQSVALKLVVDREKAIEAFVPVEYWNIRVHLKDPKTQ 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 235 RfiALWQPSDSCESYQDE----EGRLLHRPL-------AEHVVNRITGQPAIVTSYNDKRESETAPLPFSLSTLQIEAAK 303
Cdd:PRK06319 205 K--TFWAHLYSVDGKKWEkeipEGKTEDEVLlinskekADHIVELLESATYTVTRVESKEKRRNAYPPFITSTLQQEASR 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 304 RFGLSAQQVLDICQRLYE--------THKLITYPRSD-CRYLPEehfagrhsVLNAISIHQADLLPLEVMDSDrrNRCWD 374
Cdd:PRK06319 283 HFRFSSSRTMNIAQTLYEgvdldsegATGLITYMRTDsVRTDPE--------ALKQVRKYIEGTFGKEFLPSS--PNVYT 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 375 DKKV--DAHHAIIPTARAS-----KVNLTADESKVYRLVAQQYLMQFCPDAQFRkcVIELDIAGGKFI---AKARFLAEA 444
Cdd:PRK06319 353 TKKMaqDAHEAIRPTDITLtpeklRSKLTEDQYKLYSLIWKRFVASQMIPAIYD--TLAIRITTNKGIdlrATGSLLKFK 430
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 445 GWRTLLGSKERDE--ENEGAPLPVVEKGAELLCERGEVVERQTQPPRPFTDASLLsamtgiarfvqdKELKKvlratDGL 522
Cdd:PRK06319 431 GFLAVYEEKRDDEgdEEENIHLPKLHEQDVLTKEELSAEQAFTKPLPRFTEASLV------------KELEK-----SGI 493
|
490 500 510
....*....|....*....|....*....|...
gi 951133904 523 GTEATRAGIIELLFKRTFLFKKGRYIHASPAGR 555
Cdd:PRK06319 494 GRPSTYATIMNKIQSREYTLKENQRLRPTELGK 526
|
|
| TOP1Bc |
smart00436 |
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA ... |
129-223 |
1.03e-27 |
|
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA topoisomeraes I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase beta subunit
Pssm-ID: 214662 [Multi-domain] Cd Length: 89 Bit Score: 106.90 E-value: 1.03e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 129 VRRCLINDLNPQAVERAVERLRynREFIPLCVSALARARADWLYGINMTRAYTILGRNagydGVLSVGRVQTPVLGLVVR 208
Cdd:smart00436 1 IKRIEFSEITKKAIREALKNPR--EIDENLVNAQLARRILDRLIGFNLSRLLTKKLRN----GVLSAGRVQTPTLGLIVE 74
|
90
....*....|....*
gi 951133904 209 RDEEIEDFVAKDFFE 223
Cdd:smart00436 75 REREIKNFVPKPYWE 89
|
|
| PTZ00407 |
PTZ00407 |
DNA topoisomerase IA; Provisional |
72-586 |
2.88e-15 |
|
DNA topoisomerase IA; Provisional
Pssm-ID: 173597 [Multi-domain] Cd Length: 805 Bit Score: 79.60 E-value: 2.88e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 72 KWRLQPRPSVSKQLN-VIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLD-LATEKRQNVRRCLINDLNPQAVERAVERL 149
Cdd:PTZ00407 101 EWELLPGRRIQETLErYIEEKADNVTEIILATDPDREGELIAVHALQTIKrLYPKLKVPFSRAYMHSITEDGIRKAMRER 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 150 RYNREFIPLCVSALARARADWLYGI---NMTRAYTILGRnagydgvlSVGRVQTPVLGLVVRRDEEIEDFVA--KDFFEV 224
Cdd:PTZ00407 181 HVEACDYDLANAAETRHAMDRIFGFlgsSVVRAANSQMR--------SIGRVQTPALILINEREDKIKAFLEsnKSTFEV 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 225 KA--HIVTPADERFialwqpSDSCESYQDEEGRLLHRPLAEHVVNR-----ITGQPAIVTSYNDK-RESET-APLPFSLS 295
Cdd:PTZ00407 253 QAmcQFPSPHGTTF------SQVVTITPDRKGGASHWATEAEARRCleqwkLNNCTGFSVPLEPKpQPSVVpPPQPFTMA 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 296 TLQIEAAKRFGLSAQQVLDICQRLYETHKlITYPRSDCRYLPEEHFAgrhSVLNAIS-------IHQADLLPLEVMDSDR 368
Cdd:PTZ00407 327 TAIAKANRQLKYSSEMVSGCLQDLFQLGH-ITYPRTDSTRIDESALP---DIYAAVKkefgkefLYRLEDRTVSAQEGKG 402
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 369 RNRCWDDKKV--------------DAHHAIIPT---ARASKVNLTADESKVYRLVAQQYLMQFCPDAQFRKCVIELDIAG 431
Cdd:PTZ00407 403 SKKTGKKRSTkqkkgadtpvgnveDAHEAIRPTnidTTGESLSLSPPTRAVYDLVRRNTLAVFMIPMKTEKIVATVKFTS 482
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 432 G-----KFIAKARFLAEAGWRTLL--GSK-------ERDEE----NEGAPL---------------------PVVEKGAE 472
Cdd:PTZ00407 483 GsgeklEFELQGKRVVEPGWTRAFhkGDKgttgpaeETDEDitavEEGAPVvpslsqeefkaimnlrsqlgsGVQKGFFE 562
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 473 LlcERGEVVERQTQPPRPFTDASLLsamtgiarfvqdKELKKvlratDGLGTEATRAGIIELLFKRTFLF--KKGRyIHA 550
Cdd:PTZ00407 563 L--RSPQVRENRPVPPLPHSEGTLI------------EELKN-----NGVGRPSTYPMIVKTLLARGYIAvnPKGR-CET 622
|
570 580 590 600
....*....|....*....|....*....|....*....|..
gi 951133904 551 SPAGRALIH----ALPDIAarpDM--TAHWESTLTQISEKNC 586
Cdd:PTZ00407 623 TPVGRMLVEtaksTFPSIV---DIgfTAAFEKKLDRIAKPGP 661
|
|
| TopG2 |
COG1110 |
Reverse gyrase [Replication, recombination and repair]; |
85-556 |
7.67e-14 |
|
Reverse gyrase [Replication, recombination and repair];
Pssm-ID: 440727 [Multi-domain] Cd Length: 1219 Bit Score: 75.40 E-value: 7.67e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 85 LNVIKQLLQQADEVVHAGDPDREGqllvdEVLDYlDLATEKR---QNVRRCLINDLNPQAVERAverLRYNREFIPLCVS 161
Cdd:COG1110 741 VEALRELATEVDEVLIGTDPDTEG-----EKIGW-DVYNLLRpyaKNIKRIEFHEVTRKAILEA---LKNPREIDENLVE 811
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 162 A-LARARADWLYGINMTRaytILGRNAGYdGVLSVGRVQTPVLGLVVRRDEEiedfVAKDffEVKAHIVTPADERFialw 240
Cdd:COG1110 812 AqIVRRIEDRWIGFTLSQ---KLWKVFGN-RNLSAGRVQTPVLGWIIERYEE----SRKS--KKYLIILTLENGRL---- 877
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 241 qpsdSCESYQDEEGRLLHRPLAEhvvnritGQPAIVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQRLY 320
Cdd:COG1110 878 ----ELSIEDLKEAEEVRKALEK-------EVKVKVKKVEEEEEELNPLPPYTTDTLLRDASRRLGLSAEETMRLAQDLF 946
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 321 EThKLITYPRSDCRYLPEehfAGrhsvlnaISIHQaDLLPLEVMDSDRRNRCWDDKkvDAHHAIIPT------------- 387
Cdd:COG1110 947 ES-GLITYHRTDSTRVSD---AG-------IAVAK-EYISERFGEEYFKPRRWGEG--GAHEAIRPTrpldaedlrrlie 1012
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 388 ARASKV--NLTADESKVY-----RLVAQQylMQfcpDAQFRKCVIELDIAGGKFIAKARFLA---EAGWRTLlgskerde 457
Cdd:COG1110 1013 EGVIELpiPLTRRHLRLYdlifrRFMASQ--MR---PAKVEKVKLRVSLELPGGEIEEERIVeiiEDGFLLI-------- 1079
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 458 enegapLPVVEKGAELLCERGEVVE---RQTQPPRPFTDASLLSAMtgiarfvqdkelKKVlratdGLGTEATRAGIIEL 534
Cdd:COG1110 1080 ------YPPIKVEPELKEGEYKVTEvkiRKVPKVPLYTQGDLVREM------------KER-----GIGRPSTYAKIVET 1136
|
490 500
....*....|....*....|....
gi 951133904 535 LFKRTFLF--KKGRYIHASPAGRA 556
Cdd:COG1110 1137 LLRRGYVVesKKGKKLVPTKLGIE 1160
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
2-130 |
2.17e-12 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 63.14 E-value: 2.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 2 RLFIAEKPSLARAIADILPkphrrgdgfiacGSDQMVTWCVGHLLEQAQPDAYdsryarwsladlpiipekwrlqprpsv 81
Cdd:pfam01751 1 ELIIVEGPSDAIALEKALG------------GGFQAVVAVLGHLLSLEKGPKK--------------------------- 41
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 951133904 82 sKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLDLATEKRQNVR 130
Cdd:pfam01751 42 -KALKALKELALKAKEVILATDPDREGEAIALKLLELKELLENAGGRVE 89
|
|
| TOPRIM |
smart00493 |
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins; |
1-119 |
2.16e-08 |
|
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins;
Pssm-ID: 214695 [Multi-domain] Cd Length: 75 Bit Score: 51.49 E-value: 2.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 1 MRLFIAEKPSLARAIADILpkphrrgdgfiacGSDQMVTWCVGHLLEQaqpdaydsryarwsladlpiipekwrlqprps 80
Cdd:smart00493 1 KVLIIVEGPADAIALEKAG-------------GKRGNVVALGGHLLSK-------------------------------- 35
|
90 100 110
....*....|....*....|....*....|....*....
gi 951133904 81 vsKQLNVIKQLLQQAdEVVHAGDPDREGQLLVDEVLDYL 119
Cdd:smart00493 36 --EQIKLLKKLAKKA-EVILATDPDREGEAIAWELAELL 71
|
|
| TOPRIM_TopoIA_TopoI |
cd03363 |
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA ... |
1-147 |
4.23e-07 |
|
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173783 [Multi-domain] Cd Length: 123 Bit Score: 49.10 E-value: 4.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 1 MRLFIAEKPSLARAIADILpkphrrgdgfiacGSDQMVTWCVGHLLEQAQPDAY-DSRYARWSlADLPIIPEKWrlqprp 79
Cdd:cd03363 1 KKLVIVESPAKAKTIKKYL-------------GKEYEVLASVGHIRDLPKKGLGvDGEDDGFE-PKYVVIPGKK------ 60
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 951133904 80 svsKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLDLatekRQNVRRCLINDLNPQAVERAVE 147
Cdd:cd03363 61 ---KVVKELKKLAKKADEIYLATDPDREGEAIAWHLAEVLKL----KKNVKRVVFNEITKEAIKEALK 121
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| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
1-134 |
6.52e-04 |
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Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 38.95 E-value: 6.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951133904 1 MRLFIAEKPSLARAIADILpkphrrgdgfiacGSDQMVTWCVGHLLEqaqpdaydsryarwsladlpiipekwrlqprps 80
Cdd:cd00188 1 KKLIIVEGPSDALALAQAG-------------GYGGAVVALGGHALN--------------------------------- 34
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 951133904 81 vsKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLDlatEKRQNVRRCLI 134
Cdd:cd00188 35 --KTRELLKRLLGEAKEVIIATDADREGEAIALRLLELLK---SLGKKVRRLLL 83
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