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Conserved domains on  [gi|951142721|ref|WP_057623826|]
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MULTISPECIES: phosphatase PAP2 family protein [Vibrio]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 256)

type 2 phosphatidic acid phosphatase (PAP2) family protein may be a histidine phosphatase or a vanadium haloperoxidase, and is predicted to be a transmembrane protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_like super family cl00474
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 57-242 2.95e-24

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


The actual alignment was detected with superfamily member PRK10699:

Pssm-ID: 469784  Cd Length: 244  Bit Score: 97.02  E-value: 2.95e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951142721  57 GFLITLAVLSLLVLTLKFSKAKLVSLCLQLGVLLVLSFAAKTFLKSSTESPRPYTEYLVTQEVVEmPELFYELPLVEKNA 136
Cdd:PRK10699  53 GILTHVLLCGWFLWCLRFRLKAALVLFAILAAAILVGQGVKSWIKERVQEPRPFVVWLEKTHHIP-VDEFYTLKRAERGE 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951142721 137 AIE---SVQDKVSDWRTRHWLGETDYSFPSGHMIFvGVCLAFFG-GLFLEAKRFYLVGGLLVWAGGVAYSRVWLGMHRPE 212
Cdd:PRK10699 132 LVKeqlAEQSNIPQWLRSHWQKETGFAFPSGHTMF-AASWALLAvGLLWPRRRYKTVALLMLWATGVMGSRLLLGMHWPR 210

                        170       180       190
                 ....*....|....*....|....*....|
gi 951142721 213 DLAASIAFAGLIYLLVPLIPTKKIEPLLPQ 242
Cdd:PRK10699 211 DLVVATLISWLLVTVATWLAQRICGPLTPP 240
 
Name Accession Description Interval E-value
PRK10699 PRK10699
phosphatidylglycerophosphatase B; Provisional
 57-242 2.95e-24

phosphatidylglycerophosphatase B; Provisional


Pssm-ID: 182658  Cd Length: 244  Bit Score: 97.02  E-value: 2.95e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951142721  57 GFLITLAVLSLLVLTLKFSKAKLVSLCLQLGVLLVLSFAAKTFLKSSTESPRPYTEYLVTQEVVEmPELFYELPLVEKNA 136
Cdd:PRK10699  53 GILTHVLLCGWFLWCLRFRLKAALVLFAILAAAILVGQGVKSWIKERVQEPRPFVVWLEKTHHIP-VDEFYTLKRAERGE 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951142721 137 AIE---SVQDKVSDWRTRHWLGETDYSFPSGHMIFvGVCLAFFG-GLFLEAKRFYLVGGLLVWAGGVAYSRVWLGMHRPE 212
Cdd:PRK10699 132 LVKeqlAEQSNIPQWLRSHWQKETGFAFPSGHTMF-AASWALLAvGLLWPRRRYKTVALLMLWATGVMGSRLLLGMHWPR 210

                        170       180       190
                 ....*....|....*....|....*....|
gi 951142721 213 DLAASIAFAGLIYLLVPLIPTKKIEPLLPQ 242
Cdd:PRK10699 211 DLVVATLISWLLVTVATWLAQRICGPLTPP 240
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 25-231 1.48e-12

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 64.29  E-value: 1.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951142721  25 FLIFGSHFDLGSAVLPFYGAVMTFVTYSAGNQGFLITLAVLSLLVLTLKFSKAKLVSLCLQLGVLLVLSFAAKTFLKSST 104
Cdd:COG0671   17 ADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKYLF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951142721 105 ESPRPYTEYLVTQEVVEmpelfyelplveknaaiesvqdkvsdwrtrhwlgETDYSFPSGHMIFVgvcLAFFGGLFLEAK 184
Cdd:COG0671   97 GRPRPFVVPDLELLLGT----------------------------------AGGYSFPSGHAAAA---FALALVLALLLP 139

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 951142721 185 RFYLVGGLLVWAGGVAYSRVWLGMHRPEDLAASIAFAGLIYLLVPLI 231
Cdd:COG0671  140 RRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLAL 186
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 152-228 1.50e-10

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 57.09  E-value: 1.50e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 951142721 152 HWLGETDYSFPSGHMIFVGVCLAFFGGLFLEAK-RFYLVGGLLVWAGGVAYSRVWLGMHRPEDLAASIAFAGLIYLLV 228
Cdd:cd01610   44 LLLTEGGYSFPSGHAAFAFALALFLALLLPRRLlRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLV 121
acidPPc smart00014
Acid phosphatase homologues;
143-228 4.65e-10

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 55.82  E-value: 4.65e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951142721   143 DKVSDWRTRHWLGETDYSFPSGHMIFVGVCLAFFGGLFLE-AKRFYLVGGLLVWAGGVAYSRVWLGMHRPEDLAASIAFA 221
Cdd:smart00014  29 GDACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYLPArAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLG 108


                   ....*..
gi 951142721   222 GLIYLLV 228
Cdd:smart00014 109 ILIAAVL 115
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 153-234 1.06e-07

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 49.34  E-value: 1.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951142721  153 WLGETDYSFPSGH---MIFVGVCLAFFGGLFLEAKRFYLVGGLLVWAGGVAYSRVWLGMHRPEDLAASIAFAGLIYLLVP 229
Cdd:pfam01569  40 TLPGLGYSFPSGHsatAFALALLLALLLRRLRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVY 119


                  ....*
gi 951142721  230 LIPTK 234
Cdd:pfam01569 120 RLVPK 124
 
Name Accession Description Interval E-value
PRK10699 PRK10699
phosphatidylglycerophosphatase B; Provisional
 57-242 2.95e-24

phosphatidylglycerophosphatase B; Provisional


Pssm-ID: 182658  Cd Length: 244  Bit Score: 97.02  E-value: 2.95e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951142721  57 GFLITLAVLSLLVLTLKFSKAKLVSLCLQLGVLLVLSFAAKTFLKSSTESPRPYTEYLVTQEVVEmPELFYELPLVEKNA 136
Cdd:PRK10699  53 GILTHVLLCGWFLWCLRFRLKAALVLFAILAAAILVGQGVKSWIKERVQEPRPFVVWLEKTHHIP-VDEFYTLKRAERGE 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951142721 137 AIE---SVQDKVSDWRTRHWLGETDYSFPSGHMIFvGVCLAFFG-GLFLEAKRFYLVGGLLVWAGGVAYSRVWLGMHRPE 212
Cdd:PRK10699 132 LVKeqlAEQSNIPQWLRSHWQKETGFAFPSGHTMF-AASWALLAvGLLWPRRRYKTVALLMLWATGVMGSRLLLGMHWPR 210

                        170       180       190
                 ....*....|....*....|....*....|
gi 951142721 213 DLAASIAFAGLIYLLVPLIPTKKIEPLLPQ 242
Cdd:PRK10699 211 DLVVATLISWLLVTVATWLAQRICGPLTPP 240
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 25-231 1.48e-12

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 64.29  E-value: 1.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951142721  25 FLIFGSHFDLGSAVLPFYGAVMTFVTYSAGNQGFLITLAVLSLLVLTLKFSKAKLVSLCLQLGVLLVLSFAAKTFLKSST 104
Cdd:COG0671   17 ADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKYLF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951142721 105 ESPRPYTEYLVTQEVVEmpelfyelplveknaaiesvqdkvsdwrtrhwlgETDYSFPSGHMIFVgvcLAFFGGLFLEAK 184
Cdd:COG0671   97 GRPRPFVVPDLELLLGT----------------------------------AGGYSFPSGHAAAA---FALALVLALLLP 139

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 951142721 185 RFYLVGGLLVWAGGVAYSRVWLGMHRPEDLAASIAFAGLIYLLVPLI 231
Cdd:COG0671  140 RRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLAL 186
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 152-228 1.50e-10

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 57.09  E-value: 1.50e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 951142721 152 HWLGETDYSFPSGHMIFVGVCLAFFGGLFLEAK-RFYLVGGLLVWAGGVAYSRVWLGMHRPEDLAASIAFAGLIYLLV 228
Cdd:cd01610   44 LLLTEGGYSFPSGHAAFAFALALFLALLLPRRLlRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLV 121
acidPPc smart00014
Acid phosphatase homologues;
143-228 4.65e-10

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 55.82  E-value: 4.65e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951142721   143 DKVSDWRTRHWLGETDYSFPSGHMIFVGVCLAFFGGLFLE-AKRFYLVGGLLVWAGGVAYSRVWLGMHRPEDLAASIAFA 221
Cdd:smart00014  29 GDACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYLPArAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLG 108


                   ....*..
gi 951142721   222 GLIYLLV 228
Cdd:smart00014 109 ILIAAVL 115
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 152-231 8.72e-08

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 50.69  E-value: 8.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951142721 152 HWLGETDYSFPSGH----MIFVGVcLAFF--GGLFLEAKRFYLVGGLLVWAGGVAYSRVWLGMHRPEDLAASIAFAGLIY 225
Cdd:cd03392   94 LLVPEGGYSFPSGHamgaTVLYGF-LAYLlaRRLPRRRVRILLLILAAILILLVGLSRLYLGVHYPSDVLAGWLLGLAWL 172


                 ....*.
gi 951142721 226 LLVPLI 231
Cdd:cd03392  173 ALLILL 178
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 153-234 1.06e-07

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 49.34  E-value: 1.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951142721  153 WLGETDYSFPSGH---MIFVGVCLAFFGGLFLEAKRFYLVGGLLVWAGGVAYSRVWLGMHRPEDLAASIAFAGLIYLLVP 229
Cdd:pfam01569  40 TLPGLGYSFPSGHsatAFALALLLALLLRRLRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVY 119


                  ....*
gi 951142721  230 LIPTK 234
Cdd:pfam01569 120 RLVPK 124
PAP2_BcrC_like cd03385
PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as ...
 158-228 1.18e-06

PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from Bacillus subtilis posesses undecaprenyl pyrophosphate (UPP) phospatase activity, and it is hypothesized that it competes with bacitracin for UPP, increasing the cell's resistance to bacitracin.


Pssm-ID: 239480  Cd Length: 144  Bit Score: 46.87  E-value: 1.18e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 951142721 158 DYSFPSGHMIfvgvcLAF-FGGLFLEAKRFYLVGGLLVWAGGVAYSRVWLGMHRPEDLAASIAFAGLIYLLV 228
Cdd:cd03385   76 DSSFPSDHTT-----LFFsIAFSLLLRRRKWAGWILLILALLVAWSRIYLGVHYPLDMLGAALVAVLSALLV 142
PAP2_like_3 cd03393
PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 84-227 1.40e-05

PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239487 [Multi-domain]  Cd Length: 125  Bit Score: 43.51  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951142721  84 LQLGVLLVLSFAAKTFLKSSTESPRPYTeylvtqevvempelfyelPLVEKNAAIESvqdkvsdwrtrhwlgETDYSFPS 163
Cdd:cd03393   16 RYLGLALCASGYLNAALKEVFKIPRPFT------------------YDGIQAIYEES---------------AGGYGFPS 62

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 951142721 164 GHmifVGVCLAFFGGLFLEAKR--FYLVGGLLVWagGVAYSRVWLGMHRPEDLAASIAFAGLIYLL 227
Cdd:cd03393   63 GH---AQTSATFWGSLMLHVRKkwFTLIGVVLVV--LISFSRLYLGVHWPSDVIGGVLIGLLVLVL 123
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 159-229 1.45e-05

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 43.85  E-value: 1.45e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 951142721 159 YSFPSGHMIFVGVCLAFFggLFLEAKRFYLVGGLLVWAGGVAYSRVWLGMHRPEDLAASIAFAGLIYLLVP 229
Cdd:cd03391   91 YSFPSGHASRAAFVARFL--LNHLVLAVPLRVLLVLWATVVGISRVLLGRHHVLDVLAGAFLGYLEALLVE 159
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 40-227 4.14e-05

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 43.02  E-value: 4.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951142721  40 PFYGAVMTFVTysaGNQGFLITLAVLSLLVLTLKFSKAKLVSLClqlgVLLVLSFAAKT---FLKSSTESPRPYTeylvt 116
Cdd:cd03395   20 PLLDDLMPFLT---GKKLSVPIFLLLALFILFRKGPIGLLILLL----VLLAVGFADQLasgFLKPLVARLRPCN----- 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951142721 117 qevvempelfyelplveknaAIESVQDKVSDWRTRhwlgetDYSFPSGHMIFVGVcLAFFGGLFLEAKRFYLVggLLVWA 196
Cdd:cd03395   88 --------------------ALDGVRLVVLGDQGG------SYSFASSHAANSFA-LALFIWLFFRRGLFSPV--LLLWA 138

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 951142721 197 GGVAYSRVWLGMHRPEDLAA----SIAFAGLIYLL 227
Cdd:cd03395  139 LLVGYSRVYVGVHYPGDVIAgaliGIISGLLFYLL 173
PAP2_SPPase1 cd03388
PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an ...
 148-227 2.41e-04

PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second messenger in the cell, and extracellularly by binding to G-protein coupled receptors of the endothelial differentiation gene family.


Pssm-ID: 239482  Cd Length: 151  Bit Score: 40.29  E-value: 2.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951142721 148 WRTRHWLGETDYSFPSGHMIfVGVCLAFFGGLFL----EAKRFYLVGGLLVWAGGVAYSRVWLGMHRPEDLAASIAFAGL 223
Cdd:cd03388   67 VRLTMSSAALEYGFPSTHAM-NATAISFYLLIYLydryQYPFVLGLILALFYSTLVCLSRIYMGMHSVLDVIAGSLIGVL 145


                 ....
gi 951142721 224 IYLL 227
Cdd:cd03388  146 ILLF 149
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 160-221 1.78e-03

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 38.07  E-value: 1.78e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 951142721 160 SFPSGHMIFVGvclAFFGGLFLEAKRF---YLVGGLLvwaggVAYSRVWLGMHRPEDLAASIAFA 221
Cdd:cd03389  119 SFPSGHSATAG---AAAAALALLFPRYrwaFILLALL-----IAFSRVIVGAHYPSDVIAGSLLG 175
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 157-209 3.33e-03

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 37.25  E-value: 3.33e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 951142721 157 TDYSFPSGHMIFVGVCLAFF--------GGLFLEAKRFYLVGGLLVWAGGVAYSRVWLGMH 209
Cdd:cd03382   79 SGYGMPSSHSQFMGFFAVYLllfiylrlGRLNSLVSRFLLSLGLLLLALLVSYSRVYLGYH 139
PAP2_haloperoxidase cd03398
PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as ...
 160-219 3.77e-03

PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen peroxide forming dioxygen. They are likely to participate in the biosynthesis of halogenated natural products, such as volatile halogenated hydrocarbons, chiral halogenated terpenes, acetogenins and indoles.


Pssm-ID: 239492  Cd Length: 232  Bit Score: 37.40  E-value: 3.77e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 951142721 160 SFPSGHMIFVGVCL----AFFGGLFL------EAKRFYLVGGLLVW------AGGVAYSRVWLGMHRPEDLAASIA 219
Cdd:cd03398  146 SYPSGHATFAGAAAtvlkALFGSDKVpdtvsePDEGGPSTGVTRVWaelnelADEVAISRVYAGVHFRSDDAAGAA 221
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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