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Conserved domains on  [gi|951506569|ref|WP_057872610|]
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nitroreductase family protein [Liquorilactobacillus ghanensis]

Protein Classification

nitroreductase family protein( domain architecture ID 10002498)

nitroreductase family protein may catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor

CATH:  3.40.109.10|2.20.180.10
EC:  1.-.-.-
Gene Ontology:  GO:0016491
PubMed:  29078300|7601851
SCOP:  3001947

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 3-145 2.88e-24

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


:

Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 92.22  E-value: 2.88e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569   3 TMKTLLTRQAVRRYPATQITAEQLQQLLQAANAAPVGMGEYdNFHLTVVQSPAVIEQLERF---SDRHPYYGAPTVIIVS 79
Cdd:COG0778    1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQ-PWRFVVVRDPELRERLAEAlaeANQEWVADAPVLIVVC 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 951506569  80 A------KSPGPMELLSIGGIVENMALSATELGLASCdilgaiAMGVAKDSALSRQIGIPTGFQPCFSLAVG 145
Cdd:COG0778   80 AdpdrseKVPERYALLDAGIAAQNLLLAARALGLGTC------WIGGFDPEKVRELLGLPEGEEPVALLALG 145
 
Name Accession Description Interval E-value
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 3-145 2.88e-24

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 92.22  E-value: 2.88e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569   3 TMKTLLTRQAVRRYPATQITAEQLQQLLQAANAAPVGMGEYdNFHLTVVQSPAVIEQLERF---SDRHPYYGAPTVIIVS 79
Cdd:COG0778    1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQ-PWRFVVVRDPELRERLAEAlaeANQEWVADAPVLIVVC 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 951506569  80 A------KSPGPMELLSIGGIVENMALSATELGLASCdilgaiAMGVAKDSALSRQIGIPTGFQPCFSLAVG 145
Cdd:COG0778   80 AdpdrseKVPERYALLDAGIAAQNLLLAARALGLGTC------WIGGFDPEKVRELLGLPEGEEPVALLALG 145
Nitro_FMN_reductase cd02062
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 7-145 5.28e-19

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380311 [Multi-domain]  Cd Length: 139  Bit Score: 78.11  E-value: 5.28e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569   7 LLTRQAVRRYPATQITAEQLQQLLQAANAAPVGMgeydN---FHLTVVQSPAVIEQLERFSDRH--PYYGAPTVIIVSAK 81
Cdd:cd02062    1 IKTRRSIRKFTDKPVPEEKLRKILEAARLAPSAG----NlqpWRFIVVRDREKKEKLAKLAAPNqkFIAGAPVVIVVVAD 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 951506569  82 S--PGPMELLSIGGIVENMALSATELGLASCdilgAIAMGVAKDSALSRQIGIPTGFQPCFSLAVG 145
Cdd:cd02062   77 PdkSRPWALEDAGAAAQNLLLAAAALGLGSC----WIGGFDFREDKVRELLGIPENLRPVALIAIG 138
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 7-145 3.62e-15

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 68.96  E-value: 3.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569    7 LLTRQAVRRYPATQITAEQLQQLLQAANAAPVGMGEYdNFHLTVVQSPAVIEQL------------ERFSDRHPY----- 69
Cdd:pfam00881   1 IRQRRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQ-PWRFYVVTDGELRYRLaeaalelllvepAAALLLLLRrdanl 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569   70 --------YGAPTVIIV----------SAKSPGPMELLSIGGIVENMALSATELGLASCdilgaiAMGVAKDSALSRQIG 131
Cdd:pfam00881  80 klllqdflRGAPVLIVItaslstylrkAAERAYREALLDAGAAAQNLLLAATSLGLGSC------PIGGFDAAAVRELLG 153

                         170
                  ....*....|....
gi 951506569  132 IPTGFQPCFSLAVG 145
Cdd:pfam00881 154 LPDDERLVGLIAVG 167
PRK10765 PRK10765
oxygen-insensitive NADPH nitroreductase;
3-145 3.48e-03

oxygen-insensitive NADPH nitroreductase;


Pssm-ID: 182710  Cd Length: 240  Bit Score: 36.49  E-value: 3.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569   3 TMKTLLTRQAVRRYPATQITAEQLQQLLQAANAAPvgmgeyDNFHLTV-----VQSPAVIEQLERFSDRHPYY-GAPTVI 76
Cdd:PRK10765   4 TIELILSHRSIRHFTDEPISEAQREAIINAARAAS------SSSFLQCssiirITDKALREALVELTGGQKYVaQAAEFW 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569  77 -----------IVSAKSPGPMELLSIG----GIVENMALSATE-LGLASCDIlGAIAMGVAKDSALsrqIGIPTGFQPCF 140
Cdd:PRK10765  78 vfcadfnrhlqICPDAQLGLAEQLLIGavdtAIMAQNALLAAEsLGLGGVYI-GGLRNNIEAVTEL---LKLPQHVLPLF 153


                 ....*
gi 951506569 141 SLAVG 145
Cdd:PRK10765 154 GLCLG 158
 
Name Accession Description Interval E-value
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 3-145 2.88e-24

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 92.22  E-value: 2.88e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569   3 TMKTLLTRQAVRRYPATQITAEQLQQLLQAANAAPVGMGEYdNFHLTVVQSPAVIEQLERF---SDRHPYYGAPTVIIVS 79
Cdd:COG0778    1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQ-PWRFVVVRDPELRERLAEAlaeANQEWVADAPVLIVVC 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 951506569  80 A------KSPGPMELLSIGGIVENMALSATELGLASCdilgaiAMGVAKDSALSRQIGIPTGFQPCFSLAVG 145
Cdd:COG0778   80 AdpdrseKVPERYALLDAGIAAQNLLLAARALGLGTC------WIGGFDPEKVRELLGLPEGEEPVALLALG 145
Nitro_FMN_reductase cd02062
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 7-145 5.28e-19

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380311 [Multi-domain]  Cd Length: 139  Bit Score: 78.11  E-value: 5.28e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569   7 LLTRQAVRRYPATQITAEQLQQLLQAANAAPVGMgeydN---FHLTVVQSPAVIEQLERFSDRH--PYYGAPTVIIVSAK 81
Cdd:cd02062    1 IKTRRSIRKFTDKPVPEEKLRKILEAARLAPSAG----NlqpWRFIVVRDREKKEKLAKLAAPNqkFIAGAPVVIVVVAD 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 951506569  82 S--PGPMELLSIGGIVENMALSATELGLASCdilgAIAMGVAKDSALSRQIGIPTGFQPCFSLAVG 145
Cdd:cd02062   77 PdkSRPWALEDAGAAAQNLLLAAAALGLGSC----WIGGFDFREDKVRELLGIPENLRPVALIAIG 138
PnbA_NfnB-like cd02136
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ...
 6-145 1.69e-15

nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.


Pssm-ID: 380313 [Multi-domain]  Cd Length: 152  Bit Score: 69.15  E-value: 1.69e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569   6 TLLTRQAVRRYPATQITAEQLQQLLQAANAAPVGMGEYDNfHLTVVQSPAvieqLERFSDRhpYYGAPTVIIVSA-KSPG 84
Cdd:cd02136    1 AIKSRRSVRAFKDKPVPKETIEKILEAARRAPSGKNTQPW-RVYVVTGKA----RERLKKA--FFGAPVALFLTMdKVLG 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 951506569  85 PMELLSIGGIVENMALSATELGLASCdILGAIAMGVAKdsaLSRQIGIPTGFQPCFSLAVG 145
Cdd:cd02136   74 PWSWFDLGAFLQNLMLAAHALGLGTC-PQGALAGYPDV---VRKELGIPDDEELVCGIALG 130
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 7-145 3.62e-15

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 68.96  E-value: 3.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569    7 LLTRQAVRRYPATQITAEQLQQLLQAANAAPVGMGEYdNFHLTVVQSPAVIEQL------------ERFSDRHPY----- 69
Cdd:pfam00881   1 IRQRRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQ-PWRFYVVTDGELRYRLaeaalelllvepAAALLLLLRrdanl 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569   70 --------YGAPTVIIV----------SAKSPGPMELLSIGGIVENMALSATELGLASCdilgaiAMGVAKDSALSRQIG 131
Cdd:pfam00881  80 klllqdflRGAPVLIVItaslstylrkAAERAYREALLDAGAAAQNLLLAATSLGLGSC------PIGGFDAAAVRELLG 153

                         170
                  ....*....|....
gi 951506569  132 IPTGFQPCFSLAVG 145
Cdd:pfam00881 154 LPDDERLVGLIAVG 167
nitroreductase cd20609
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 10-110 2.20e-14

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380330 [Multi-domain]  Cd Length: 145  Bit Score: 66.26  E-value: 2.20e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569  10 RQAVRRYPATQITAEQLQQLLQAANAAPVGMgeydNF---HLTVVQSPAVIEQLERFSDRHpyYGAPTVIIV------SA 80
Cdd:cd20609    9 RYSVRKFSDKPVEKEKLDKILEAGRLAPTAV----NYqpqRILVVRSEEALEKLAKATPRF--FGAPLVIVVcydkdeSW 82

                         90       100       110
                 ....*....|....*....|....*....|...
gi 951506569  81 KSPGPMELLSI--GGIV-ENMALSATELGLASC 110
Cdd:cd20609   83 KRPYDGKDSGDidAAIVaTHMMLAATELGLGTC 115
nitroreductase cd02151
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 7-110 7.41e-13

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers..


Pssm-ID: 380326 [Multi-domain]  Cd Length: 157  Bit Score: 62.55  E-value: 7.41e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569   7 LLTRQAVRRYPATQITAEQLQQLLQAANAAPVGMGeYDNFHLTVVQSPAVIEQLERfSDRH---PYYGAPTVIIV---SA 80
Cdd:cd02151    3 LKKRRSIRKYTDEPIEEEKLEEILEAALLAPSSRN-SRPVEFIVVDDKETLKKLSE-CKPHgsaFLKGAPAAIVVladTE 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 951506569  81 KSPGPMELLSIGGIveNMALSATELGLASC 110
Cdd:cd02151   81 KSDTWIEDASIAAT--YIQLAAESLGLGSC 108
nitroreductase cd02150
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 7-145 3.44e-12

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380325 [Multi-domain]  Cd Length: 156  Bit Score: 60.69  E-value: 3.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569   7 LLTRQAVRRYPATQITAEQLQQLLQAANAAPVGMGEyDNFHLTVVQSPaviEQLERFSDRHPY----YGAPTVIIVSA-- 80
Cdd:cd02150    1 ILTRRSIRKYTDKPVEEEDIEKLLRAAMAAPSAGNQ-QPWHFIVVTDR---EKLDKIAEAHPYgkmlKEAPLAIVVCGdp 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 951506569  81 -KSPGP---MELLSIGgiVENMALSATELGlascdiLGAIAMGVAKD----SALSRQIGIPTGFQPCFSLAVG 145
Cdd:cd02150   77 sKEKAPgywVQDCSAA--TENILLAAHALG------LGAVWLGVYPFeervKAIREILNIPENIIPFCVIALG 141
nitroreductase cd20608
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 9-133 2.18e-10

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380329 [Multi-domain]  Cd Length: 145  Bit Score: 55.80  E-value: 2.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569   9 TRQAVRRYPATQITAEQLQQLLQAANAAPVGMgeydN---FHLTVVQSPAVIEQLERFsdRHPYYG----APTVIIVSAK 81
Cdd:cd20608    6 TRRSVRRFSDKPVEEEKLEKILEAARLAPSWA----NkqcWRFIVVTDKETLSELAKK--ESPSNGwlkdAPVIIVVCAD 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 951506569  82 SP--GPME-----LLSIGGIVENMALSATELGLASCDIlgaiamGVAKDSALSRQIGIP 133
Cdd:cd20608   80 PKdsGWLNgqnyyLVDAAIAMQNLMLAATDLGLGTCWI------GAFDEKKVKEILGIP 132
nitroreductase cd20610
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 10-135 1.57e-09

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380331 [Multi-domain]  Cd Length: 167  Bit Score: 53.82  E-value: 1.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569  10 RQAVRRYPATQITAEQLQQLLQAANAAPVGMgEYDNFHLTVVQSPAVIEQLE-------------------RFSDRHP-- 68
Cdd:cd20610    4 RRSIRKFKPDPVPKEDIEKILEAANWAPSGM-NRQNWEFVVVKGGEKIEKIGisikkkneeiarllekvfaEKPIRFRkf 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 951506569  69 ------YYGAPTVIIVSAKSPGPME-----LLSIGGIVENMALSATELGLASCDILGAIAMgvakDSALSRQIGIPTG 135
Cdd:cd20610   83 rrfftlFGGAPVLVVVYTEPYKPPEerkpdLQSVSAAIQNLLLAAHALGLGTCWMTGPLYA----EDEIEEILEIPDD 156
YdjA-like cd02135
nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the ...
 4-110 5.52e-09

nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.


Pssm-ID: 380312 [Multi-domain]  Cd Length: 162  Bit Score: 52.22  E-value: 5.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569   4 MKTLLTRQAVRRYPATQ-ITAEQLQQLLQAANAAPV-GMGEydNFHLTVVQSpaviEQLERFSD---------------- 65
Cdd:cd02135    1 LELIKTRRSIRKFKLTGaPPEEQLEELLEAAMWAPNhGKLE--PWRFIVVTG----EGRERLAEllaaaaaarapgadpe 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 951506569  66 -----RHPYYGAPTVIIVSAKsPGPM-------ELLSIGGIVENMALSATELGLASC 110
Cdd:cd02135   75 klekaREKALRAPVVIAVVAK-PDEDpkvpeweQYAAVGAAVQNLLLAAHALGLGAV 130
nitroreductase cd02139
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 4-110 2.54e-08

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380316 [Multi-domain]  Cd Length: 165  Bit Score: 50.55  E-value: 2.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569   4 MKTLLTRQAVRRYPATQITAEQLQQLLQAANAAPVGMgeydN---FHLTVVQSPAVIEQL-ERFSDRHPYYGAPTVIIVS 79
Cdd:cd02139    2 YEAIKKRRSIRKYKPTPVEEEKLLRILEAARLAPSAK----NrqpWRFIVVKDKELKEKLaEAANGQKFIAEAPVVIVAC 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 951506569  80 AKspgPMELLSIGGI----------VENMALSATELGLASC 110
Cdd:cd02139   78 AD---PSESGMGCGKpyylvdvaiaMEHLVLAATEEGLGTC 115
NfsA-like cd02146
nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin ...
 3-145 1.14e-07

nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.


Pssm-ID: 380322 [Multi-domain]  Cd Length: 229  Bit Score: 49.54  E-value: 1.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569   3 TMKTLLTRQAVRRYPATQITAEQLQQLLQAANAAPVGMgeydNFHLT---VVQSPAVIEQLERFSDRHPYY-GAPTVIIV 78
Cdd:cd02146    1 TIETILNHRSVRKFTDEPLTDETLETLIAAAQSASTSS----NLQAYsviVVTDPELREKLAELAGNQPYVaQAPVFLVF 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569  79 SA--------------KSPG--PMELLSIG----GIV-ENMALSATELGLASCdILGAIamgVAKDSALSRQIGIPTGFQ 137
Cdd:cd02146   77 CAdlyrhqkiaeeaggKDVGldYLESFLVGvvdaALAaQNALVAAESLGLGIV-YIGGI---RNNPEEVIELLGLPEYVF 152


                 ....*...
gi 951506569 138 PCFSLAVG 145
Cdd:cd02146  153 PLFGLTVG 160
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
 10-156 1.91e-07

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 47.62  E-value: 1.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569  10 RQAVRRY-PATQITAEQLQQLLQAANAAPVGMgeydNF---HLTVVQSPAVIEQL-ERFSDRHPYYGAPTVIIVSAkspg 84
Cdd:cd02137    7 RRSVRNFdPDHKIPKEELKEILELATLAPSSF----NLqpwRFVVVRDPELKAKLaEAAYNQPQVTTASAVILVLG---- 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 951506569  85 pmeLLSIGGIVENMALSATELGLASCDILGAIAmgvakdSALSRQIGIPTGFQPCFSLAVG--QTSAPLSQRTP 156
Cdd:cd02137   79 ---DLNAGLAAMNLMLAAKAKGYDTCPMGGFDK------EKVAELLNLPDRYVPVLLIAIGkaADKAPRSGRLP 143
nitroreductase_FeS-like cd02143
nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family ...
 7-145 1.87e-06

nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family utilize FMN as a cofactor. This family may be involved in the reduction of flavin or nitroaromatic compounds via an obligatory two-electron transfer. Nitroreductase is homodimer. Each subunit contains one FMN molecule.


Pssm-ID: 380319 [Multi-domain]  Cd Length: 187  Bit Score: 45.54  E-value: 1.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569   7 LLTRQAVRRYPATQITAEQLQQLLQAANAAPVGMgeydNF---HLTVVQSPA--------VIEQLERFSDRHPYY----- 70
Cdd:cd02143    2 LRSRRSIRRYKDKPVPRETLEKLLDIARYAPTGH----NSqpvHWLVVDDPEkvrrlaelVIDWMRELIKEDPELagklf 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569  71 -----------------GAPTVIIVSA--KSPGPMELLSIggivenmALSATELGLASCDiLGA----IAMGVAKDSALS 127
Cdd:cd02143   78 ldgivaawekgidvilrGAPHLVVAHApkDAPTPPVDCAI-------ALTYLELAAPSLG-LGTcwagFFTAAANNYPPL 149

                        170
                 ....*....|....*....
gi 951506569 128 RQ-IGIPTGFQPCFSLAVG 145
Cdd:cd02143  150 REaLGLPEGHKVGGAMMLG 168
TM1586_NiRdase pfam14512
Putative TM nitroreductase; Compared with the more traditional NADH oxidase/flavin reductase ...
 2-110 5.43e-04

Putative TM nitroreductase; Compared with the more traditional NADH oxidase/flavin reductase family, this family is a duplication, consisting of two similar domains arranged as the subunits of the dimeric NADH oxidase/flavin reductase with one conserved active site.


Pssm-ID: 405236 [Multi-domain]  Cd Length: 214  Bit Score: 38.81  E-value: 5.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569    2 DTMKTLLTRQAVRRYPATQITAEQLQQLLQAANAAPvgmGEYD-NFHLTVVQSPAVIEQLE--RFSDRHPYygaptVIIV 78
Cdd:pfam14512   1 NLYEAIFKRHSVRKYTDEPIPEELLEELKNAIDEIN---KLSGlNIQLVIDDPDAFKGKAKygKFKGVPNY-----IAAY 72

                          90       100       110
                  ....*....|....*....|....*....|..
gi 951506569   79 SAKSPGPMELlsIGGIVENMALSATELGLASC 110
Cdd:pfam14512  73 GEKDDDLLEN--AGYYGEQIVLYATALGLGTC 102
nitroreductase cd03370
uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus ...
 9-80 1.15e-03

uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus thermophilus NADH oxidase and other, uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380327 [Multi-domain]  Cd Length: 191  Bit Score: 37.68  E-value: 1.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 951506569   9 TRQAVRRYPATQITAEQLQQLLQAANAAPVGMgeydN---FHLTVVQSPAVIEQLERFSDRHPYYG-APTVIIVSA 80
Cdd:cd03370    7 SRRSIRKYTQEPVPDEDLREILRLAGLAPSAW----NiqpWRFVVVRDAELKEQLQAAAYGQAQVTsAPAVIVIYS 78
NfsB-like cd02149
nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This ...
 7-114 1.39e-03

nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family includes FRase I in Vibrio fischeri, wihich reduces FMN into FMNH2 as part of the bioluminescent reaction. The family also includes oxygen-insensitive nitroreductases that use NADH or NADPH as an electron donor in the ping pong bi bi mechanism. This type of nitroreductase can be used in cancer chemotherapy to activate a range of prodrugs.


Pssm-ID: 380324 [Multi-domain]  Cd Length: 156  Bit Score: 37.23  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569   7 LLTRQAVRRYPATQ-ITAEQLQQLLQAANAAP--VGMgeyDNFHLTVVQSPAVIEQLERFS--DRHPYYGAPTVIIVSAK 81
Cdd:cd02149    6 LNFRYATKKFDPNKkISDEDLETILEALRLSPssFGL---EPWKFLVVENPELKAKLAPAAwfNQPQIKDASHVVVFLAK 82

                         90       100       110
                 ....*....|....*....|....*....|...
gi 951506569  82 SPGPMELLSIGgiVENMALSATELGLASCDILG 114
Cdd:cd02149   83 KDWSAKQTYIA--LGNMLLAAAMLGIDSCPIEG 113
PRK10765 PRK10765
oxygen-insensitive NADPH nitroreductase;
3-145 3.48e-03

oxygen-insensitive NADPH nitroreductase;


Pssm-ID: 182710  Cd Length: 240  Bit Score: 36.49  E-value: 3.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569   3 TMKTLLTRQAVRRYPATQITAEQLQQLLQAANAAPvgmgeyDNFHLTV-----VQSPAVIEQLERFSDRHPYY-GAPTVI 76
Cdd:PRK10765   4 TIELILSHRSIRHFTDEPISEAQREAIINAARAAS------SSSFLQCssiirITDKALREALVELTGGQKYVaQAAEFW 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951506569  77 -----------IVSAKSPGPMELLSIG----GIVENMALSATE-LGLASCDIlGAIAMGVAKDSALsrqIGIPTGFQPCF 140
Cdd:PRK10765  78 vfcadfnrhlqICPDAQLGLAEQLLIGavdtAIMAQNALLAAEsLGLGGVYI-GGLRNNIEAVTEL---LKLPQHVLPLF 153


                 ....*
gi 951506569 141 SLAVG 145
Cdd:PRK10765 154 GLCLG 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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