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Conserved domains on  [gi|966352624|ref|WP_058401121|]
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class II aldolase/adducin family protein [Pseudomonas savastanoi]

Protein Classification

class II aldolase/adducin family protein( domain architecture ID 10012869)

class II aldolase/adducin family protein similar to L-fuculose phosphate aldolase, which catalyzes the reversible aldol cleavage of L-fuculose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK07044 PRK07044
aldolase II superfamily protein; Provisional
 20-271 1.61e-141

aldolase II superfamily protein; Provisional


:

Pssm-ID: 235916  Cd Length: 252  Bit Score: 397.68  E-value: 1.61e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624  20 SVRDRVSPQEWDVRVKLAAAYRLAALKRWTDHIYTHFSARVPGPDEHFLINAFGLLFDEITASNLVKVDIDGTIVDdPTG 99
Cdd:PRK07044   5 AVPARVSPAEWQARVDLAAAYRLVALLGWDDLIYTHISARVPGEEHHFLINPYGLLFDEITASNLVKIDLDGNVVD-DSP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624 100 LGINYAGYVIHSAIHAARHDLQAVLHTHTRDGIAVSAQKDGLLPISQHSIAFSGRVAYHGYEGIALDLSERERLVADLGD 179
Cdd:PRK07044  84 YPVNPAGFTIHSAIHAARPDAHCVMHTHTTAGVAVSAQRDGLLPLSQHALQFYGRLAYHDYEGIALDLDEGERLVADLGD 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624 180 KSVMILRNHGLLTGGVSVEHAFQQLHALEYACNIQIAAQSAGnAELVFPPREVIAKVEEQAKAikDGHGPGVARHWNALI 259
Cdd:PRK07044 164 KPAMLLRNHGLLTVGRTVAEAFLLMYTLERACEIQVAAQAGG-GELVLPPPEVAERTARQSLF--DPGAGAGELAWPALL 240

                        250
                 ....*....|..
gi 966352624 260 RELERNGTDYRD 271
Cdd:PRK07044 241 RKLDRIDPGYRD 252
 
Name Accession Description Interval E-value
PRK07044 PRK07044
aldolase II superfamily protein; Provisional
 20-271 1.61e-141

aldolase II superfamily protein; Provisional


Pssm-ID: 235916  Cd Length: 252  Bit Score: 397.68  E-value: 1.61e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624  20 SVRDRVSPQEWDVRVKLAAAYRLAALKRWTDHIYTHFSARVPGPDEHFLINAFGLLFDEITASNLVKVDIDGTIVDdPTG 99
Cdd:PRK07044   5 AVPARVSPAEWQARVDLAAAYRLVALLGWDDLIYTHISARVPGEEHHFLINPYGLLFDEITASNLVKIDLDGNVVD-DSP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624 100 LGINYAGYVIHSAIHAARHDLQAVLHTHTRDGIAVSAQKDGLLPISQHSIAFSGRVAYHGYEGIALDLSERERLVADLGD 179
Cdd:PRK07044  84 YPVNPAGFTIHSAIHAARPDAHCVMHTHTTAGVAVSAQRDGLLPLSQHALQFYGRLAYHDYEGIALDLDEGERLVADLGD 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624 180 KSVMILRNHGLLTGGVSVEHAFQQLHALEYACNIQIAAQSAGnAELVFPPREVIAKVEEQAKAikDGHGPGVARHWNALI 259
Cdd:PRK07044 164 KPAMLLRNHGLLTVGRTVAEAFLLMYTLERACEIQVAAQAGG-GELVLPPPEVAERTARQSLF--DPGAGAGELAWPALL 240

                        250
                 ....*....|..
gi 966352624 260 RELERNGTDYRD 271
Cdd:PRK07044 241 RKLDRIDPGYRD 252
AraD COG0235
5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar ...
 46-239 1.52e-63

5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) [Amino acid transport and metabolism, Carbohydrate transport and metabolism]; 5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440005 [Multi-domain]  Cd Length: 208  Bit Score: 198.13  E-value: 1.52e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624  46 KRWTDHIYTHFSARVPgpDEHFLINAFGLLFDEITASNLVKVDIDGTIVDdptGLGINYAGYVIHSAIHAARHDLQAVLH 125
Cdd:COG0235   20 RGLVDGTAGNISVRLD--DDRFLITPSGVDFGELTPEDLVVVDLDGNVVE---GDLKPSSETPLHLAIYRARPDVGAVVH 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624 126 THTRDGIAVSAQKDGLLPISQ-HSIAFSGRVAYHGYEGIAlDLSERERLVADLGDKSVMILRNHGLLTGGVSVEHAFQQL 204
Cdd:COG0235   95 THSPYATALSALGEPLPPLEQtEAAAFLGDVPVVPYAGPG-TEELAEAIAEALGDRPAVLLRNHGVVVWGKDLAEAFDRA 173

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 966352624 205 HALEYACNIQIAAQSAGNAELVfpPREVIAKVEEQ 239
Cdd:COG0235  174 EVLEEAARIQLLALALGGPLVL--SDEEIDKLARK 206
Aldolase_II smart01007
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 46-215 2.39e-50

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 214970 [Multi-domain]  Cd Length: 185  Bit Score: 163.58  E-value: 2.39e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624    46 KRWTDHIYTHFSARVpGPDEHFLINAFGLLFDEITASNLVKVDIDGTIVDdPTGLGINYAGYVIHSAIHAARHDLQAVLH 125
Cdd:smart01007  11 RGLVEGTGGNISARV-GEEDLFLITPSGVDFGELTASDLVVVDLDGNVVE-GGGGPKPSSETPLHLAIYRARPDVGAVVH 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624   126 THTRDGIAVSAQKD--GLLPISQHSIAFSGRVAYHGYEGIALDLSERERLVAD-----LGDKSVMILRNHGLLTGGVSVE 198
Cdd:smart01007  89 THSPYATALAALGKplPLLPTEQAAAFLGGEIPYAPYAGPGTELAEEGAELAEalaeaLPDRPAVLLRNHGLLVWGKTLE 168

                          170
                   ....*....|....*..
gi 966352624   199 HAFQQLHALEYACNIQI 215
Cdd:smart01007 169 EAFDLAEELEEAAEIQL 185
Aldolase_II pfam00596
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 46-215 2.42e-50

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 459862 [Multi-domain]  Cd Length: 178  Bit Score: 163.49  E-value: 2.42e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624   46 KRWTDHIYTHFSARVPgpDEHFLINAFGLLFDEITASNLVKVDIDGTIVDDptGLGINyAGYVIHSAIHAARHDLQAVLH 125
Cdd:pfam00596  13 RGLVEGTGGNISVRLP--GDGFLITPSGVDFGELTPEDLVVVDLDGNVVEG--GLKPS-SETPLHLAIYRARPDAGAVVH 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624  126 THTRDGIAVSAQKDGLLPISQHSIAFSG-RVAYHGYEGIALDLsERERLVADLG-DKSVMILRNHGLLTGGVSVEHAFQQ 203
Cdd:pfam00596  88 THSPYATALSLAKEGLPPITQEAADFLGgDIPIIPYYTPGTEE-LGERIAEALGgDRKAVLLRNHGLLVWGKTLEEAFYL 166

                         170
                  ....*....|..
gi 966352624  204 LHALEYACNIQI 215
Cdd:pfam00596 167 AEELERAAEIQL 178
Aldolase_II cd00398
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes ...
 57-241 8.04e-30

Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). Class II enzymes are further divided into two sub-classes A and B. This family includes class II A aldolases and adducins which has not been ascribed any enzymatic function. Members of this class are primarily bacterial and eukaryotic in origin and include L-fuculose-1-phosphate, L-rhamnulose-1-phosphate aldolases and L-ribulose-5-phosphate 4-epimerases. They all share the ability to promote carbon-carbon bond cleavage and stabilize enolate intermediates using divalent cations.


Pssm-ID: 238232 [Multi-domain]  Cd Length: 209  Bit Score: 111.30  E-value: 8.04e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624  57 SARVPgPDEHFLINAFGLLFDEITASNLVKVDIDGTIVDD--PTglginyAGYVIHSAIHAARHDLQAVLHTHTRDGIAV 134
Cdd:cd00398   28 SARDR-DRGYFLITPSGVDYEEMTASDLVVVDAQGKVVEGkkPS------SETPLHLALYRARPDIGCIVHTHSTHATAV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624 135 SAQKDGLLPIS--QHSIAFSGRVAYHGYEGIaLDLSERERLVADLG--DKSVMILRNHGLLTGGVSVEHAFQQLHALEYA 210
Cdd:cd00398  101 SQLKEGLIPAGhtACAVYFTGDIPCTPYMTP-ETGEDEIGTQRALGfpNSKAVLLRNHGLFAWGPTLDEAFHLAVVLEVA 179

                        170       180       190
                 ....*....|....*....|....*....|.
gi 966352624 211 CNIQIAAQSAGnAELVFPPREVIAKVEEQAK 241
Cdd:cd00398  180 AEIQLKALSMG-GQLPPISLELLNKEYLRKH 209
salvage_mtnB TIGR03328
methylthioribulose-1-phosphate dehydratase; Members of this family are the ...
 56-214 1.25e-10

methylthioribulose-1-phosphate dehydratase; Members of this family are the methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway. This pathway allows methylthioadenosine, left over from polyamine biosynthesis, to be recycled to methionine. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 274521 [Multi-domain]  Cd Length: 192  Bit Score: 59.20  E-value: 1.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624   56 FSARVPGpdEHFLINAFGLLFDEITASNLVKVDIDGTIVDdpTGLGINyAGYVIHSAIHAARhDLQAVLHTHTRDGIAVS 135
Cdd:TIGR03328  21 LSARLDE--DEILITPSGVDKGRLTPEDFLVVDLQGKPVS--GGLKPS-AETLLHTQLYRLT-GAGAVLHTHSVEATVLS 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624  136 A--QKDGLLPISQHSI--AFSGrvaYHGYE------------GIAlDLSERERLVADLGDKSVMIL-RNHGLLTGGVSVE 198
Cdd:TIGR03328  95 RlyPSNGGFELEGYEMlkGLPG---ITTHEdtlvvpiientqDIA-RLADSVAPALNAYPDVPGVLiRGHGLYAWGRDWE 170

                         170
                  ....*....|....*...
gi 966352624  199 HAFQQLHALEY--ACNIQ 214
Cdd:TIGR03328 171 EAKRHLEALEFlfECELE 188
 
Name Accession Description Interval E-value
PRK07044 PRK07044
aldolase II superfamily protein; Provisional
 20-271 1.61e-141

aldolase II superfamily protein; Provisional


Pssm-ID: 235916  Cd Length: 252  Bit Score: 397.68  E-value: 1.61e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624  20 SVRDRVSPQEWDVRVKLAAAYRLAALKRWTDHIYTHFSARVPGPDEHFLINAFGLLFDEITASNLVKVDIDGTIVDdPTG 99
Cdd:PRK07044   5 AVPARVSPAEWQARVDLAAAYRLVALLGWDDLIYTHISARVPGEEHHFLINPYGLLFDEITASNLVKIDLDGNVVD-DSP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624 100 LGINYAGYVIHSAIHAARHDLQAVLHTHTRDGIAVSAQKDGLLPISQHSIAFSGRVAYHGYEGIALDLSERERLVADLGD 179
Cdd:PRK07044  84 YPVNPAGFTIHSAIHAARPDAHCVMHTHTTAGVAVSAQRDGLLPLSQHALQFYGRLAYHDYEGIALDLDEGERLVADLGD 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624 180 KSVMILRNHGLLTGGVSVEHAFQQLHALEYACNIQIAAQSAGnAELVFPPREVIAKVEEQAKAikDGHGPGVARHWNALI 259
Cdd:PRK07044 164 KPAMLLRNHGLLTVGRTVAEAFLLMYTLERACEIQVAAQAGG-GELVLPPPEVAERTARQSLF--DPGAGAGELAWPALL 240

                        250
                 ....*....|..
gi 966352624 260 RELERNGTDYRD 271
Cdd:PRK07044 241 RKLDRIDPGYRD 252
AraD COG0235
5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar ...
 46-239 1.52e-63

5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) [Amino acid transport and metabolism, Carbohydrate transport and metabolism]; 5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440005 [Multi-domain]  Cd Length: 208  Bit Score: 198.13  E-value: 1.52e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624  46 KRWTDHIYTHFSARVPgpDEHFLINAFGLLFDEITASNLVKVDIDGTIVDdptGLGINYAGYVIHSAIHAARHDLQAVLH 125
Cdd:COG0235   20 RGLVDGTAGNISVRLD--DDRFLITPSGVDFGELTPEDLVVVDLDGNVVE---GDLKPSSETPLHLAIYRARPDVGAVVH 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624 126 THTRDGIAVSAQKDGLLPISQ-HSIAFSGRVAYHGYEGIAlDLSERERLVADLGDKSVMILRNHGLLTGGVSVEHAFQQL 204
Cdd:COG0235   95 THSPYATALSALGEPLPPLEQtEAAAFLGDVPVVPYAGPG-TEELAEAIAEALGDRPAVLLRNHGVVVWGKDLAEAFDRA 173

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 966352624 205 HALEYACNIQIAAQSAGNAELVfpPREVIAKVEEQ 239
Cdd:COG0235  174 EVLEEAARIQLLALALGGPLVL--SDEEIDKLARK 206
PRK06661 PRK06661
hypothetical protein; Provisional
 50-263 5.76e-56

hypothetical protein; Provisional


Pssm-ID: 168637  Cd Length: 231  Bit Score: 179.64  E-value: 5.76e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624  50 DHIYTHFSARVPGPDeHFLINAFGLLFDEITASNLVKVDIDGTIVDDPTgLGINYAGYVIHSAIHAARHDLQAVLHTHTR 129
Cdd:PRK06661  21 DHTYTHLSARPKNAD-FYYIYPFGLRFEEVTTENLLKVSLDGQILEGEE-YQYNKTGYFIHGSIYKTRPDISAIFHYHTP 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624 130 DGIAVSAQKDGLLPISQHSIAFSGRVAYHGYEGIALDL-SERERLVADLGDKSVMILRNHGLLTGGVSVEHAFQQLHALE 208
Cdd:PRK06661  99 ASIAVSALKCGLLPISQWALHFYDRISYHNYNSLALDAdKQSSRLVNDLKQNYVMLLRNHGAITCGKTIHEAMFYTYHLE 178

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 966352624 209 YACNIQIAAQSAGNAELVFPPREVIAKVEEQAKAIKDGHGpgvARHWNALIRELE 263
Cdd:PRK06661 179 QACKTQCLLNSTKKQELIIPSVEICKKTVKDLLSFEEDLG---KRDWAAWLRLIK 230
Aldolase_II smart01007
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 46-215 2.39e-50

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 214970 [Multi-domain]  Cd Length: 185  Bit Score: 163.58  E-value: 2.39e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624    46 KRWTDHIYTHFSARVpGPDEHFLINAFGLLFDEITASNLVKVDIDGTIVDdPTGLGINYAGYVIHSAIHAARHDLQAVLH 125
Cdd:smart01007  11 RGLVEGTGGNISARV-GEEDLFLITPSGVDFGELTASDLVVVDLDGNVVE-GGGGPKPSSETPLHLAIYRARPDVGAVVH 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624   126 THTRDGIAVSAQKD--GLLPISQHSIAFSGRVAYHGYEGIALDLSERERLVAD-----LGDKSVMILRNHGLLTGGVSVE 198
Cdd:smart01007  89 THSPYATALAALGKplPLLPTEQAAAFLGGEIPYAPYAGPGTELAEEGAELAEalaeaLPDRPAVLLRNHGLLVWGKTLE 168

                          170
                   ....*....|....*..
gi 966352624   199 HAFQQLHALEYACNIQI 215
Cdd:smart01007 169 EAFDLAEELEEAAEIQL 185
Aldolase_II pfam00596
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 46-215 2.42e-50

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 459862 [Multi-domain]  Cd Length: 178  Bit Score: 163.49  E-value: 2.42e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624   46 KRWTDHIYTHFSARVPgpDEHFLINAFGLLFDEITASNLVKVDIDGTIVDDptGLGINyAGYVIHSAIHAARHDLQAVLH 125
Cdd:pfam00596  13 RGLVEGTGGNISVRLP--GDGFLITPSGVDFGELTPEDLVVVDLDGNVVEG--GLKPS-SETPLHLAIYRARPDAGAVVH 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624  126 THTRDGIAVSAQKDGLLPISQHSIAFSG-RVAYHGYEGIALDLsERERLVADLG-DKSVMILRNHGLLTGGVSVEHAFQQ 203
Cdd:pfam00596  88 THSPYATALSLAKEGLPPITQEAADFLGgDIPIIPYYTPGTEE-LGERIAEALGgDRKAVLLRNHGLLVWGKTLEEAFYL 166

                         170
                  ....*....|..
gi 966352624  204 LHALEYACNIQI 215
Cdd:pfam00596 167 AEELERAAEIQL 178
PRK06486 PRK06486
aldolase;
52-271 5.40e-42

aldolase;


Pssm-ID: 235814  Cd Length: 262  Bit Score: 144.47  E-value: 5.40e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624  52 IYTHFSARVPGPDEHFLINAFGLLFDEITASNLVKVDIDGTIVD-----DPTGLginyagyVIHSAIHAARHDLQAVLHT 126
Cdd:PRK06486  47 ICNHFSAVLPGHDDLFLVNPYGYAFSEITASDLLICDFDGNVLAgrgepEATAF-------FIHARIHRAIPRAKAAFHT 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624 127 HTRDGIAVS-AQKDGLLPISQHSIAFSGRVAY-HGYEGIALDLSERERLVADLGDKSVMILRNHGLLTGGVSVEHAFQQL 204
Cdd:PRK06486 120 HMPYATALSlTEGRPLTTLGQTALKFYGRTAVdEDYNGLALDAAEGDRIARAMGDADIVFLKNHGVMVCGPRIAEAWDDL 199

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966352624 205 HALEYACNIQIAAQSAGNAeLVFPPREVIAKVEEQakaIKDGHGPGVARHWNALIRELERNGTDYRD 271
Cdd:PRK06486 200 YYLERACEVQVLAMSTGRP-LVPVDPAIAAAVARQ---MREGDRESARLHLEALRRTLDREEPAYRT 262
PRK06208 PRK06208
class II aldolase/adducin family protein;
55-221 1.06e-41

class II aldolase/adducin family protein;


Pssm-ID: 235743  Cd Length: 274  Bit Score: 144.36  E-value: 1.06e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624  55 HFSARVPGPDEHFLINAFGLLFDEITASNLVKVDIDGTIVDdptGLG-INYAGYVIHSAIHAARHDLQAVLHTHTRDGIA 133
Cdd:PRK06208  66 HITARDPELPDHFWVNPLGVHFSQIKVSDLLLVDHDGEVVE---GDRpLNRAAFAIHSAIHEARPDVVAAAHTHSTYGKA 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624 134 VSAQKDGLLPISQHSIAFSGRVA-YHGYEGIALDLSERERLVADLGDKSVMILRNHGLLTGGVSVEHAFQQLHALEYACN 212
Cdd:PRK06208 143 WSTLGRPLDPITQDACAFYEDHAlFDDFTGVVVDTSEGRRIAAALGTHKAVILQNHGLLTVGPSVDAAAWWFIALERACQ 222


                 ....*....
gi 966352624 213 IQIAAQSAG 221
Cdd:PRK06208 223 TQLLAEAAG 231
PRK07490 PRK07490
hypothetical protein; Provisional
 47-271 1.54e-30

hypothetical protein; Provisional


Pssm-ID: 236031 [Multi-domain]  Cd Length: 245  Bit Score: 114.43  E-value: 1.54e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624  47 RWTDH------IYTHFSARVPGPDEHFLINAFGLLFDEITASNLVKVDID------GTIVDDPTGLGInyagyviHSAIH 114
Cdd:PRK07490  20 RWIARlgmheaVANHFSAAVSADGKQFLLNPKWKHFSRIRASDLLLLDADdpstaeRPDVPDATAWAI-------HGQIH 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624 115 AARHDLQAVLHTHTRDGIAVSAQKDG-LLPISQHSIAFSGRVAY-HGYEGIALDlSERERLVADLGDKSVMILRNHGLLT 192
Cdd:PRK07490  93 RRLPHARCVMHVHSVYATALACLADPtLPPIDQNTARFFNRVAVdTLYGGMALE-EEGERLAGLLGDKRRLLMGNHGVLV 171

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966352624 193 GGVSVEHAFQQLHALEYACNIQIAAQSAGnAELVFPPREVIAKVEEQAKAIKDghgpGVARHWNALIRELERNGTDYRD 271
Cdd:PRK07490 172 TGDTVAEAFDDLYYFERACQTYITALSTG-QPLRVLSDAVAEKTARDWEDYPG----FSRQHFAELKALLDEEDPSYAD 245
Aldolase_II cd00398
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes ...
 57-241 8.04e-30

Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). Class II enzymes are further divided into two sub-classes A and B. This family includes class II A aldolases and adducins which has not been ascribed any enzymatic function. Members of this class are primarily bacterial and eukaryotic in origin and include L-fuculose-1-phosphate, L-rhamnulose-1-phosphate aldolases and L-ribulose-5-phosphate 4-epimerases. They all share the ability to promote carbon-carbon bond cleavage and stabilize enolate intermediates using divalent cations.


Pssm-ID: 238232 [Multi-domain]  Cd Length: 209  Bit Score: 111.30  E-value: 8.04e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624  57 SARVPgPDEHFLINAFGLLFDEITASNLVKVDIDGTIVDD--PTglginyAGYVIHSAIHAARHDLQAVLHTHTRDGIAV 134
Cdd:cd00398   28 SARDR-DRGYFLITPSGVDYEEMTASDLVVVDAQGKVVEGkkPS------SETPLHLALYRARPDIGCIVHTHSTHATAV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624 135 SAQKDGLLPIS--QHSIAFSGRVAYHGYEGIaLDLSERERLVADLG--DKSVMILRNHGLLTGGVSVEHAFQQLHALEYA 210
Cdd:cd00398  101 SQLKEGLIPAGhtACAVYFTGDIPCTPYMTP-ETGEDEIGTQRALGfpNSKAVLLRNHGLFAWGPTLDEAFHLAVVLEVA 179

                        170       180       190
                 ....*....|....*....|....*....|.
gi 966352624 211 CNIQIAAQSAGnAELVFPPREVIAKVEEQAK 241
Cdd:cd00398  180 AEIQLKALSMG-GQLPPISLELLNKEYLRKH 209
PRK07090 PRK07090
class II aldolase/adducin domain protein; Provisional
 57-221 1.12e-17

class II aldolase/adducin domain protein; Provisional


Pssm-ID: 180832  Cd Length: 260  Bit Score: 80.07  E-value: 1.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624  57 SARVPGPDEhFLINAFGLLFDEITASNLVKVDIDGTIVDdptGLGINYAGYVIHSAIHAARHDLQAVLHTHTRDGIAVSA 136
Cdd:PRK07090  56 TARAEAPGT-YYTQRLGLGFDEITASNLLLVDEDLNVLD---GEGMPNPANRFHSWIYRARPDVNCIIHTHPPHVAALSM 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624 137 QKDGLLpISQHSIA-FSGRVAYHG-YEGIALDLSERERLVADLGDKSVMILRNHGLLTGGVSVEHAFQQLHALEYACNIQ 214
Cdd:PRK07090 132 LEVPLV-VSHMDTCpLYDDCAFLKdWPGVPVGNEEGEIISAALGDKRAILLSHHGQLVAGKSIEEACVLALLIERAARLQ 210


                 ....*..
gi 966352624 215 IAAQSAG 221
Cdd:PRK07090 211 LLAMAAG 217
salvage_mtnB TIGR03328
methylthioribulose-1-phosphate dehydratase; Members of this family are the ...
 56-214 1.25e-10

methylthioribulose-1-phosphate dehydratase; Members of this family are the methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway. This pathway allows methylthioadenosine, left over from polyamine biosynthesis, to be recycled to methionine. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 274521 [Multi-domain]  Cd Length: 192  Bit Score: 59.20  E-value: 1.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624   56 FSARVPGpdEHFLINAFGLLFDEITASNLVKVDIDGTIVDdpTGLGINyAGYVIHSAIHAARhDLQAVLHTHTRDGIAVS 135
Cdd:TIGR03328  21 LSARLDE--DEILITPSGVDKGRLTPEDFLVVDLQGKPVS--GGLKPS-AETLLHTQLYRLT-GAGAVLHTHSVEATVLS 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624  136 A--QKDGLLPISQHSI--AFSGrvaYHGYE------------GIAlDLSERERLVADLGDKSVMIL-RNHGLLTGGVSVE 198
Cdd:TIGR03328  95 RlyPSNGGFELEGYEMlkGLPG---ITTHEdtlvvpiientqDIA-RLADSVAPALNAYPDVPGVLiRGHGLYAWGRDWE 170

                         170
                  ....*....|....*...
gi 966352624  199 HAFQQLHALEY--ACNIQ 214
Cdd:TIGR03328 171 EAKRHLEALEFlfECELE 188
PRK06833 PRK06833
L-fuculose-phosphate aldolase;
69-241 1.76e-10

L-fuculose-phosphate aldolase;


Pssm-ID: 180717 [Multi-domain]  Cd Length: 214  Bit Score: 59.38  E-value: 1.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624  69 INAFGLLFDEITASNLVKVDIDGTIVDdptGLGINYAGYVIHSAIHAARHDLQAVLHTHTRDGIAVSAQkDGLLPISQHS 148
Cdd:PRK06833  42 ITPSGIDYFEIKPEDIVIMDLDGKVVE---GERKPSSELDMHLIFYRNREDINAIVHTHSPYATTLACL-GWELPAVHYL 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624 149 IAFSG---RVA-YHGYEGIALDLSERERLVadlgDKSVMILRNHGLLTGGVSVEHAFQQLHALEYACNIQIAAQSAGnaE 224
Cdd:PRK06833 118 IAVAGpnvRCAeYATFGTKELAENAFEAME----DRRAVLLANHGLLAGANNLKNAFNIAEEIEFCAEIYYQTKSIG--E 191

                        170
                 ....*....|....*..
gi 966352624 225 LVFPPREVIAKVEEQAK 241
Cdd:PRK06833 192 PKLLPEDEMENMAEKFK 208
PRK08660 PRK08660
aldolase;
64-213 1.55e-07

aldolase;


Pssm-ID: 181527 [Multi-domain]  Cd Length: 181  Bit Score: 50.34  E-value: 1.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624  64 DEHFLINAFGLLFDEITASNLVKVDIDGTIVDDPtglgINYAGYVIHSAIHAaRHDLQAVLHTHTRDGIAVSAQKDGLLP 143
Cdd:PRK08660  30 GDGLLITRTGSMLDEITEGDVIEVGIDDDGSVDP----LASSETPVHRAIYR-RTSAKAIVHAHPPYAVALSLLEDEIVP 104

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966352624 144 ISQHSIAFSGRV----AYHGYEGIAldlserERLVADLGDKSVMILRNHGLLTGGVSVEHAFQQLHALEYACNI 213
Cdd:PRK08660 105 LDSEGLYFLGTIpvvgGDIGSGELA------ENVARALSEHKGVVVRGHGTFAIGKTLEEAYIYTSQLEHSCKV 172
PRK06557 PRK06557
L-ribulose-5-phosphate 4-epimerase; Validated
 57-200 1.58e-07

L-ribulose-5-phosphate 4-epimerase; Validated


Pssm-ID: 235829 [Multi-domain]  Cd Length: 221  Bit Score: 50.78  E-value: 1.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624  57 SARVPGPDeHFLINAFGLLFDEITASNLVKVDIDGTIVDDPTGLGINYAGyviHSAIHAARHDLQAVLHTHTRDGIAVSA 136
Cdd:PRK06557  36 SARDPGTD-LVVIKPSGVSYDDLTPEDMVVVDLDGNVVEGDLKPSSDTAS---HLYVYRHMPDVGGVVHTHSTYATAWAA 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966352624 137 QKDGlLP--ISQHSIAFSGRVAYHGYEGIALDLSERERLVADLGDKSVMIL-RNHGLLTGGVSVEHA 200
Cdd:PRK06557 112 RGEP-IPcvLTAMADEFGGPIPVGPFALIGDEAIGKGIVETLKGGRSPAVLmQNHGVFTIGKDAEDA 177
PRK08333 PRK08333
aldolase;
55-201 3.55e-05

aldolase;


Pssm-ID: 181393 [Multi-domain]  Cd Length: 184  Bit Score: 43.27  E-value: 3.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624  55 HFSARVpgpDEHFLINAFGLLFDEITASNLVKVDIDGTIVDD--PTglginyAGYVIHSAIHAARHDLQAVLHTHTRDGI 132
Cdd:PRK08333  27 NLSIRV---GNLVFIKATGSVMDELTREQVAVIDLNGNQLSSvrPS------SEYRLHLAVYRNRPDVRAIAHLHPPYSI 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966352624 133 AVSAQKDGLLP-ISQHSIAFSGRVAY-----HGYEGIALDLSERerlvadLGDKSVMILRNHGLLTGGVSVEHAF 201
Cdd:PRK08333  98 VASTLLEEELPiITPEAELYLKKIPIlpfrpAGSVELAEQVAEA------MKEYDAVIMERHGIVTVGRSLREAF 166
araD PRK13145
L-ribulose-5-phosphate 4-epimerase; Provisional
 67-247 4.79e-05

L-ribulose-5-phosphate 4-epimerase; Provisional


Pssm-ID: 183870 [Multi-domain]  Cd Length: 234  Bit Score: 43.67  E-value: 4.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624  67 FLINAFGLLFDEITASNLVKVDIDGTIV--------DDPTglginyagyviHSAIHAARHDLQAVLHTHTRDGIAvSAQK 138
Cdd:PRK13145  40 IVIKPSGVDYDELTPENMVVTDLDGNVVegdlnpssDLPT-----------HVELYKAWPEVGGIVHTHSTEAVG-WAQA 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624 139 DGLLPI--SQHSIAFSGRV-------------AYHGYEGIALdLSERERLVADLGDKSVMILRNHGLLTGGVSVEHAFQQ 203
Cdd:PRK13145 108 GRDIPFygTTHADYFYGPIpcarsltkdevngAYEKETGSVI-IEEFEKRGLDPMAVPGIVVRNHGPFTWGKNPEQAVYH 186

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 966352624 204 LHALEYacniqiAAQSAGNAELVFPpreviaKVEEQAKAIKDGH 247
Cdd:PRK13145 187 SVVLEE------VAKMNRLTEQINP------RVEPAPQYIMDKH 218
PRK08130 PRK08130
putative aldolase; Validated
 57-208 5.40e-05

putative aldolase; Validated


Pssm-ID: 181241 [Multi-domain]  Cd Length: 213  Bit Score: 43.32  E-value: 5.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624  57 SARVPgpDEHFLINAFGLLFDEITASNLVKVDIDGTIV--DDPTglginyAGYVIHSAIHAARHDLQAVLHTHTRDGIAV 134
Cdd:PRK08130  31 SARLD--DGGWLVTPTGSCLGRLDPARLSKVDADGNWLsgDKPS------KEVPLHRAIYRNNPECGAVVHLHSTHLTAL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624 135 SAQ-----KDGLLPISQHSIAFSGRVA---YH--GYEGIALDLSERERLVadlgdKSVMiLRNHGLLTGGVSVEHAFQQL 204
Cdd:PRK08130 103 SCLggldpTNVLPPFTPYYVMRVGHVPlipYYrpGDPAIAEALAGLAARY-----RAVL-LANHGPVVWGSSLEAAVNAT 176


                 ....
gi 966352624 205 HALE 208
Cdd:PRK08130 177 EELE 180
PRK08087 PRK08087
L-fuculose-phosphate aldolase;
68-208 2.00e-04

L-fuculose-phosphate aldolase;


Pssm-ID: 181226 [Multi-domain]  Cd Length: 215  Bit Score: 41.65  E-value: 2.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624  68 LINAFGLLFDEITASNLVKVDIDGtivdDPTGLGINYAGYVIHSAIHAARHDLQAVLHTHTRDGIAVSAQKDGLLPIsQH 147
Cdd:PRK08087  39 LITPTGIPYEKLTESHIVFVDGNG----KHEEGKLPSSEWRFHMAAYQTRPDANAVVHNHAVHCTAVSILNRPIPAI-HY 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966352624 148 SIAFSGR-----VAYHGY------EGIALDLSERERLvadlgdksvmILRNHGLLTGGVSVEHAFQQLHALE 208
Cdd:PRK08087 114 MIAAAGGnsipcAPYATFgtrelsEHVALALKNRKAT----------LLQHHGLIACEVNLEKALWLAHEVE 175
PRK09220 PRK09220
methylthioribulose 1-phosphate dehydratase;
56-214 6.37e-04

methylthioribulose 1-phosphate dehydratase;


Pssm-ID: 236415 [Multi-domain]  Cd Length: 204  Bit Score: 39.92  E-value: 6.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624  56 FSARVPgpDEHFLINAFGLLFDEITASNLVKVDIDGTIVDDP------TGLginyagyviHSAIHAARHDLQAVLHTHTR 129
Cdd:PRK09220  30 MSVRLD--EQHCAITVSGKDKGSLTAEDFLQVDIAGNAVPSGrkpsaeTLL---------HTQLYRLFPEIGAVLHTHSV 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966352624 130 DGIAVS--AQKDGLLpISQHSI--AFSG------RVA---YHGYEGIALdLSERerlVADLGDKSVM----ILRNHGLLT 192
Cdd:PRK09220  99 NATVLSrvEKSDALV-LEGYELqkAFAGqtthetAVVvpiFDNDQDIAR-LAAR---VAPYLDAQPLrygyLIRGHGLYC 173

                        170       180
                 ....*....|....*....|....
gi 966352624 193 GGVSVEHAFQQLHALEY--ACNIQ 214
Cdd:PRK09220 174 WGRDMAEARRHLEGLEFlfECELE 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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