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Conserved domains on  [gi|966513797|ref|WP_058530316|]
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FAD-dependent oxidoreductase [Legionella rubrilucens]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 1005091)

NAD(P)/FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; similar to the antibiotic lankacidin LkcE from Streptomyces rochei, which catalyzes both an unusual amide oxidation, and a subsequent intramolecular Mannich reaction to form the polyketide macrocycle

EC:  1.-.-.-
Gene Ontology:  GO:0016491
PubMed:  30266997

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Ppro0129 super family cl34517
Predicted flavin-containing amine oxidase [General function prediction only];
23-432 4.72e-60

Predicted flavin-containing amine oxidase [General function prediction only];


The actual alignment was detected with superfamily member COG2907:

Pssm-ID: 442151 [Multi-domain]  Cd Length: 423  Bit Score: 201.50  E-value: 4.72e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797  23 RIAIVGGGAAGVVSAWLLEQDHEITLYESQDRLGGHANSINVEVDGKKIVVEAGaeF--FNRFAYPHFMRLLNFYKIPVK 100
Cdd:COG2907    5 RIAVIGSGISGLTAAWLLSRRHDVTLFEANDRLGGHTHTVDVDLDGRTVPVDTG--FivFNERTYPNLTALFAELGVPTQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797 101 PftlvttyydTDGSELIILppyHDGQVEWQSLTPANL----RKIMN---LKVVLDV------GHHVIEE-KDSTLTLEAL 166
Cdd:COG2907   83 P---------SDMSFSVSL---DGGGLEYAGSNLNGLfaqrRNLLRprfWRMLRDIlrfnreAPALLEAgSDDDLTLGEF 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797 167 ADNIHITDVFKDTFLYPFLAAGWGVTSDEIRQFSAfsvlQYMVTSYDN-------SSNEWFEVETGLSSYVTRLSRDLKK 239
Cdd:COG2907  151 LDRNGYSEAFRDHYLLPMGAAIWSCPPDDMLDFPA----RFFVRFFHNhgllsvtDRPQWRTVKGGSREYVRRLTAGLKD 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797 240 sRIQLNSRIARITFEQGAYVIEEENGTRREFDHLVFATNANTAAQLMT--SLPEREslmkTLARVRYYDTQIAIHGDKRF 317
Cdd:COG2907  227 -RIRLNTPVRSVRRDADGVEVRTADGEEERFDHVVFATHSDQALALLAdpTPAERE----LLGAIRYQPNEAVLHTDTSL 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797 318 MPPKEKDWRVANVR-------------YNgMNSAMTIykkwKSKTPVFKSW-VTHDIRapgdkgsalPKNLYALIKYQHP 383
Cdd:COG2907  302 MPRRRRAWASWNYLldredgtrpvsvtYW-MNRLQGL----PAPTPVFVTLnPTRPID---------PEKVLARFTYEHP 367

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 966513797 384 YTDKDFFAAQKAAQAEQGQYNLWFAGMWMNDiGSHEDAIVSAIRIAERL 432
Cdd:COG2907  368 VFDLAAIAAQKRLPELQGRNRTWFCGAYWGY-GFHEDGLRSALRVAEAL 415
 
Name Accession Description Interval E-value
Ppro0129 COG2907
Predicted flavin-containing amine oxidase [General function prediction only];
23-432 4.72e-60

Predicted flavin-containing amine oxidase [General function prediction only];


Pssm-ID: 442151 [Multi-domain]  Cd Length: 423  Bit Score: 201.50  E-value: 4.72e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797  23 RIAIVGGGAAGVVSAWLLEQDHEITLYESQDRLGGHANSINVEVDGKKIVVEAGaeF--FNRFAYPHFMRLLNFYKIPVK 100
Cdd:COG2907    5 RIAVIGSGISGLTAAWLLSRRHDVTLFEANDRLGGHTHTVDVDLDGRTVPVDTG--FivFNERTYPNLTALFAELGVPTQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797 101 PftlvttyydTDGSELIILppyHDGQVEWQSLTPANL----RKIMN---LKVVLDV------GHHVIEE-KDSTLTLEAL 166
Cdd:COG2907   83 P---------SDMSFSVSL---DGGGLEYAGSNLNGLfaqrRNLLRprfWRMLRDIlrfnreAPALLEAgSDDDLTLGEF 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797 167 ADNIHITDVFKDTFLYPFLAAGWGVTSDEIRQFSAfsvlQYMVTSYDN-------SSNEWFEVETGLSSYVTRLSRDLKK 239
Cdd:COG2907  151 LDRNGYSEAFRDHYLLPMGAAIWSCPPDDMLDFPA----RFFVRFFHNhgllsvtDRPQWRTVKGGSREYVRRLTAGLKD 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797 240 sRIQLNSRIARITFEQGAYVIEEENGTRREFDHLVFATNANTAAQLMT--SLPEREslmkTLARVRYYDTQIAIHGDKRF 317
Cdd:COG2907  227 -RIRLNTPVRSVRRDADGVEVRTADGEEERFDHVVFATHSDQALALLAdpTPAERE----LLGAIRYQPNEAVLHTDTSL 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797 318 MPPKEKDWRVANVR-------------YNgMNSAMTIykkwKSKTPVFKSW-VTHDIRapgdkgsalPKNLYALIKYQHP 383
Cdd:COG2907  302 MPRRRRAWASWNYLldredgtrpvsvtYW-MNRLQGL----PAPTPVFVTLnPTRPID---------PEKVLARFTYEHP 367

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 966513797 384 YTDKDFFAAQKAAQAEQGQYNLWFAGMWMNDiGSHEDAIVSAIRIAERL 432
Cdd:COG2907  368 VFDLAAIAAQKRLPELQGRNRTWFCGAYWGY-GFHEDGLRSALRVAEAL 415
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 32-329 1.16e-16

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 81.77  E-value: 1.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797   32 AGVVSAW-LLEQDHEITLYESQDRLGGHANSinVEVDGkkIVVEAGAEFFNRfAYPHFMRLLNFYKIP----VKPFTLVT 106
Cdd:pfam01593   2 AGLAAAReLLRAGHDVTVLEARDRVGGRIRT--VRDDG--FLIELGAMWFHG-AQPPLLALLKELGLEdrlvLPDPAPFY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797  107 TYYDTDGSELiiLPPYHDGQVEWQSL--------TPANLRKIMNLKVVLDVGHHVIEEKDSTLTLEALADN--IHIT--D 174
Cdd:pfam01593  77 TVLFAGGRRY--PGDFRRVPAGWEGLlefgrllsIPEKLRLGLAALASDALDEFDLDDFSLAESLLFLGRRgpGDVEvwD 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797  175 VFKDTFLYPFLAAGWGVTSDEIRQFSAFSVLQYMVTSYDNSSNEWFeVETGLSSYVTRLSRDLKKSRIQLNSRIARITFE 254
Cdd:pfam01593 155 RLIDPELFAALPFASGAFAGDPSELSAGLALPLLWALLGEGGSLLL-PRGGLGALPDALAAQLLGGDVRLNTRVRSIDRE 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966513797  255 QGAYVIEEENGTRREFDHLVFATNANTAAQLMTSLPERESLMKTLARVRYYD-TQIAIHGDKRFMPPKEKDWRVAN 329
Cdd:pfam01593 234 GDGVTVTLTDGEVIEADAVIVTVPLGVLKRILFTPPLPPEKARAIRNLGYGPvNKVHLEFDRKFWPDLGLLGLLSE 309
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 23-285 3.70e-08

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 55.24  E-value: 3.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797  23 RIAIVGGGAAGVVSAWLLEQ---DHEITLYESQDRLGGHANSinVEVDGkkIVVEAGAEFF--NRFAYPHFMRLLNFYKi 97
Cdd:PRK11883   2 KVAIIGGGITGLSAAYRLHKkgpDADITLLEASDRLGGKIQT--VRKDG--FPIELGPESFlaRKPSAPALVKELGLED- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797  98 pvkpfTLVTTyydTDGSELIilppYHDGQV----EWQSL-TPANLRKIMNLKVVLDVGH----------HVIEEKDSTLT 162
Cdd:PRK11883  77 -----ELVAN---TTGQSYI----YVNGKLhpipPGTVMgIPTSIAPFLFAGLVSPIGKlraaadlrppRWKPGQDQSVG 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797 163 lEALADniHITDVFKDTFLYPFLAAGWGVTSDEIRQFSAF-----------SVLQYMVTSYDNSSNE----WFEVETGLS 227
Cdd:PRK11883 145 -AFFRR--RFGDEVVENLIEPLLSGIYAGDIDTLSLRATFpqlaqaedkygSLLRGMRKALPKEKKKtkgvFGTLKGGLQ 221

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966513797 228 SYVTRLSRDLKKSRIQLNSRIARITFEQGAYVIEEENGTRREFDHLVFATNANTAAQL 285
Cdd:PRK11883 222 SLIEALEEKLPAGTIHKGTPVTKIDKSGDGYEIVLSNGGEIEADAVIVAVPHPVLPSL 279
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 24-367 2.34e-07

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 52.92  E-value: 2.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797   24 IAIVGGGAAGVVSAWLLEQDH-----EITLYESQDRLGGhaNSINVEVDGkkIVVEAGAEFF--NRFAYPHFMRLLNFYK 96
Cdd:TIGR00562   5 VVIIGGGISGLCAAYYLEKEIpelpvELTLVEASDRVGG--KIQTVKEDG--YLIERGPDSFleRKKSAPDLVKDLGLEH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797   97 IPVKPFTLVTTYYDTDGsELIILPpyhdgqvewQSLTPANLRKIMNLKVVLDVGHHVIEEK--DSTLTLEALADNiHITD 174
Cdd:TIGR00562  81 VLVSDATGQRYVLVNRG-KLMPVP---------TKIAPFVKTGLFSLGGKLRAGMDFIRPAspGKDESVEEFVRR-RFGD 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797  175 VFKDTFLYPFLAagwGVTSDEIRQFS---AFSVLQYM----------------------VTSYDNSSNEWFE-VETGLSS 228
Cdd:TIGR00562 150 EVVENLIEPLLS---GIYAGDPSKLSlksTFPKFYQTeqkhgslilgmkktrnlpqgsgLQLTAKKQGQDFQtLATGLET 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797  229 YVTRLSRDLKKSRIQLNSRIARITFEQGAYVIEEENGTRREFDHLVFATNANTAAQLMTSL--PERESLMK----TLARV 302
Cdd:TIGR00562 227 LPEEIEKRLKLTKVYKGTKVTKLSHRGSNYTLELDNGVTVETDSVVVTAPHKAAAGLLSELsnSASSHLDKihspPVANV 306

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966513797  303 RYYDTQIAIHGDK---RFMPPKEKDWRVANVRYNGmnsamtiyKKWKSKTPVFKSWVTHDIRAPGDKG 367
Cdd:TIGR00562 307 NLGFPEGSVDGELegfGFLISRSSKFAILGCIFTS--------KLFPNRAPPGKTLLTAYIGGATDES 366
 
Name Accession Description Interval E-value
Ppro0129 COG2907
Predicted flavin-containing amine oxidase [General function prediction only];
23-432 4.72e-60

Predicted flavin-containing amine oxidase [General function prediction only];


Pssm-ID: 442151 [Multi-domain]  Cd Length: 423  Bit Score: 201.50  E-value: 4.72e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797  23 RIAIVGGGAAGVVSAWLLEQDHEITLYESQDRLGGHANSINVEVDGKKIVVEAGaeF--FNRFAYPHFMRLLNFYKIPVK 100
Cdd:COG2907    5 RIAVIGSGISGLTAAWLLSRRHDVTLFEANDRLGGHTHTVDVDLDGRTVPVDTG--FivFNERTYPNLTALFAELGVPTQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797 101 PftlvttyydTDGSELIILppyHDGQVEWQSLTPANL----RKIMN---LKVVLDV------GHHVIEE-KDSTLTLEAL 166
Cdd:COG2907   83 P---------SDMSFSVSL---DGGGLEYAGSNLNGLfaqrRNLLRprfWRMLRDIlrfnreAPALLEAgSDDDLTLGEF 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797 167 ADNIHITDVFKDTFLYPFLAAGWGVTSDEIRQFSAfsvlQYMVTSYDN-------SSNEWFEVETGLSSYVTRLSRDLKK 239
Cdd:COG2907  151 LDRNGYSEAFRDHYLLPMGAAIWSCPPDDMLDFPA----RFFVRFFHNhgllsvtDRPQWRTVKGGSREYVRRLTAGLKD 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797 240 sRIQLNSRIARITFEQGAYVIEEENGTRREFDHLVFATNANTAAQLMT--SLPEREslmkTLARVRYYDTQIAIHGDKRF 317
Cdd:COG2907  227 -RIRLNTPVRSVRRDADGVEVRTADGEEERFDHVVFATHSDQALALLAdpTPAERE----LLGAIRYQPNEAVLHTDTSL 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797 318 MPPKEKDWRVANVR-------------YNgMNSAMTIykkwKSKTPVFKSW-VTHDIRapgdkgsalPKNLYALIKYQHP 383
Cdd:COG2907  302 MPRRRRAWASWNYLldredgtrpvsvtYW-MNRLQGL----PAPTPVFVTLnPTRPID---------PEKVLARFTYEHP 367

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 966513797 384 YTDKDFFAAQKAAQAEQGQYNLWFAGMWMNDiGSHEDAIVSAIRIAERL 432
Cdd:COG2907  368 VFDLAAIAAQKRLPELQGRNRTWFCGAYWGY-GFHEDGLRSALRVAEAL 415
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 23-304 1.33e-24

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 105.30  E-value: 1.33e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797  23 RIAIVGGGAAGVVSAW-LLEQDHEITLYESQDRLGGHANSinVEVDGkkIVVEAGAEFFnrFA-YPHFMRLLNfykipvk 100
Cdd:COG1232    3 RVAVIGGGIAGLTAAYrLAKAGHEVTVLEASDRVGGLIRT--VEVDG--FRIDRGPHSF--LTrDPEVLELLR------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797 101 pftlvttyyDTD-GSELIILPP-----YHDGQ-VEWQSLTPANLR-KIMNLKVVLDVGHHVI---EEKDSTLTLEALADN 169
Cdd:COG1232   70 ---------ELGlGDELVWPNTrksyiYYGGKlHPLPQGPLALLRsPLLSLAGKLRALLELLaprRPPGEDESLAEFVRR 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797 170 iHITDVFKDTFLYPFLAAGWGVTSDEIRQFSAFSVLQYMVTSYD-------------NSSNEWFEVETGLSSYVTRLSRD 236
Cdd:COG1232  141 -RFGREVYERLVEPLLEGVYAGDPDELSADWAFPRLKRLELEHGslikgalalrkgaKAGEVFGYLRGGLGTLVEALAEA 219

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966513797 237 LKKSRIQLNSRIARITFEQGAYVIEEENGTRREFDHLVFATNANTAAQLMTSLPEResLMKTLARVRY 304
Cdd:COG1232  220 LEAGEIRLGTRVTAIEREGGGWRVTTSDGETIEADAVVSATPAPALARLLAPLPPE--VAAALAGIPY 285
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
23-335 5.06e-24

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 103.85  E-value: 5.06e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797  23 RIAIVGGGAAGVVSAWLLEQD-HEITLYESQDRLGGHANSINVEVDGkkIVVEAGAEFFNRfAYPHFMRLLNFYKIPVKP 101
Cdd:COG1231    9 DVVIVGAGLAGLAAARELRKAgLDVTVLEARDRVGGRVWTLRFGDDG--LYAELGAMRIPP-SHTNLLALARELGLPLEP 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797 102 FTLVT--TYYDTDGSeliilpPYHDGQVEWQSLTPANL-RKIMN-LKVVLDVGHHVIEEKDSTLTLEALADNIHITDVFK 177
Cdd:COG1231   86 FPNENgnALLYLGGK------RVRAGEIAADLRGVAELlAKLLRaLAAALDPWAHPAAELDRESLAEWLRRNGASPSARR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797 178 dtFLYPFLAAGWGVTSDEIrqfSAFSVLQYMVTsyDNSSNEWFEVETGLSSYVTRLSRDLkKSRIQLNSRIARITFEQGA 257
Cdd:COG1231  160 --LLGLLGAGEYGADPDEL---SLLDLLRYAAS--AGGGAQQFRIVGGMDQLPRALAAEL-GDRIRLGAPVTRIRQDGDG 231

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966513797 258 YVIEEENGTRREFDHLVFATNANTAAQLMTSLPERESLMKTLARVRYYD-TQIAIHGDKRFmppkekdWRvANVRYNGM 335
Cdd:COG1231  232 VTVTTDDGGTVRADAVIVTVPPSVLRRIEFDPPLPAAKRAAIQRLPYGAaIKVFLQFDRPF-------WE-EDGLYGGI 302
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 32-329 1.16e-16

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 81.77  E-value: 1.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797   32 AGVVSAW-LLEQDHEITLYESQDRLGGHANSinVEVDGkkIVVEAGAEFFNRfAYPHFMRLLNFYKIP----VKPFTLVT 106
Cdd:pfam01593   2 AGLAAAReLLRAGHDVTVLEARDRVGGRIRT--VRDDG--FLIELGAMWFHG-AQPPLLALLKELGLEdrlvLPDPAPFY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797  107 TYYDTDGSELiiLPPYHDGQVEWQSL--------TPANLRKIMNLKVVLDVGHHVIEEKDSTLTLEALADN--IHIT--D 174
Cdd:pfam01593  77 TVLFAGGRRY--PGDFRRVPAGWEGLlefgrllsIPEKLRLGLAALASDALDEFDLDDFSLAESLLFLGRRgpGDVEvwD 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797  175 VFKDTFLYPFLAAGWGVTSDEIRQFSAFSVLQYMVTSYDNSSNEWFeVETGLSSYVTRLSRDLKKSRIQLNSRIARITFE 254
Cdd:pfam01593 155 RLIDPELFAALPFASGAFAGDPSELSAGLALPLLWALLGEGGSLLL-PRGGLGALPDALAAQLLGGDVRLNTRVRSIDRE 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966513797  255 QGAYVIEEENGTRREFDHLVFATNANTAAQLMTSLPERESLMKTLARVRYYD-TQIAIHGDKRFMPPKEKDWRVAN 329
Cdd:pfam01593 234 GDGVTVTLTDGEVIEADAVIVTVPLGVLKRILFTPPLPPEKARAIRNLGYGPvNKVHLEFDRKFWPDLGLLGLLSE 309
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 23-295 6.59e-14

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 73.35  E-value: 6.59e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797  23 RIAIVGGGAAGVVSA-WLLEQDHEITLYESQDRLGGHANSINVEVDGkkIVVEAGAEFFNRfAYPHFMRLLNfyKIPVKP 101
Cdd:COG3349    5 RVVVVGGGLAGLAAAvELAEAGFRVTLLEARPRLGGRARSFPDPDTG--LPIDNGQHVLLG-CYRNTLDLLR--RIGAAD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797 102 ---FTLVTTYYDTDGSELII----LP-PYHdgqvewqsLTPANLR--------KIMNLKVVLDVGHHVIEEKDSTLTLEA 165
Cdd:COG3349   80 nlvGPEPLQFPLPGGRRWTLraprLPaPLH--------LLRALLRapglsladRLALLRLLTACRERRWRELDDISVADW 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797 166 LADNiHITDVFKDTFLYPFLAAGWGVTSDEIrqfSA---FSVLQYMVTSYDNSSNEWFeVETGLS-SYVTRLSRDLKK-- 239
Cdd:COG3349  152 LRRH-GQSPRLIRRLWEPLLLAALNTPPEQA---SArlaLTVLRETLLAGPAASDLLV-PRGPLSeLFVDPALAYLEArg 226

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966513797 240 SRIQLNSRIARITFEQGAY-VIEEENGTRREFDHLVFATNANTAAQLMTSLPERESL 295
Cdd:COG3349  227 GEVRLGTRVRALEFDGGRVtGLVLADGETVPADAVVLAVPPEVAARLLPELARLPEL 283
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
26-93 1.32e-13

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 65.25  E-value: 1.32e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966513797   26 IVGGGAAGVVSAWLL-EQDHEITLYESQDRLGGHANSINVevdgKKIVVEAGAEFFNRFAYPHFMRLLN 93
Cdd:pfam13450   1 IVGAGLAGLVAAALLaKRGFRVLVLEKRDRLGGNAYSYRV----PGYVFDYGAHIFHGSDEPNVRDLLD 65
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 23-285 3.70e-08

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 55.24  E-value: 3.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797  23 RIAIVGGGAAGVVSAWLLEQ---DHEITLYESQDRLGGHANSinVEVDGkkIVVEAGAEFF--NRFAYPHFMRLLNFYKi 97
Cdd:PRK11883   2 KVAIIGGGITGLSAAYRLHKkgpDADITLLEASDRLGGKIQT--VRKDG--FPIELGPESFlaRKPSAPALVKELGLED- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797  98 pvkpfTLVTTyydTDGSELIilppYHDGQV----EWQSL-TPANLRKIMNLKVVLDVGH----------HVIEEKDSTLT 162
Cdd:PRK11883  77 -----ELVAN---TTGQSYI----YVNGKLhpipPGTVMgIPTSIAPFLFAGLVSPIGKlraaadlrppRWKPGQDQSVG 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797 163 lEALADniHITDVFKDTFLYPFLAAGWGVTSDEIRQFSAF-----------SVLQYMVTSYDNSSNE----WFEVETGLS 227
Cdd:PRK11883 145 -AFFRR--RFGDEVVENLIEPLLSGIYAGDIDTLSLRATFpqlaqaedkygSLLRGMRKALPKEKKKtkgvFGTLKGGLQ 221

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966513797 228 SYVTRLSRDLKKSRIQLNSRIARITFEQGAYVIEEENGTRREFDHLVFATNANTAAQL 285
Cdd:PRK11883 222 SLIEALEEKLPAGTIHKGTPVTKIDKSGDGYEIVLSNGGEIEADAVIVAVPHPVLPSL 279
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 24-367 2.34e-07

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 52.92  E-value: 2.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797   24 IAIVGGGAAGVVSAWLLEQDH-----EITLYESQDRLGGhaNSINVEVDGkkIVVEAGAEFF--NRFAYPHFMRLLNFYK 96
Cdd:TIGR00562   5 VVIIGGGISGLCAAYYLEKEIpelpvELTLVEASDRVGG--KIQTVKEDG--YLIERGPDSFleRKKSAPDLVKDLGLEH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797   97 IPVKPFTLVTTYYDTDGsELIILPpyhdgqvewQSLTPANLRKIMNLKVVLDVGHHVIEEK--DSTLTLEALADNiHITD 174
Cdd:TIGR00562  81 VLVSDATGQRYVLVNRG-KLMPVP---------TKIAPFVKTGLFSLGGKLRAGMDFIRPAspGKDESVEEFVRR-RFGD 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797  175 VFKDTFLYPFLAagwGVTSDEIRQFS---AFSVLQYM----------------------VTSYDNSSNEWFE-VETGLSS 228
Cdd:TIGR00562 150 EVVENLIEPLLS---GIYAGDPSKLSlksTFPKFYQTeqkhgslilgmkktrnlpqgsgLQLTAKKQGQDFQtLATGLET 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966513797  229 YVTRLSRDLKKSRIQLNSRIARITFEQGAYVIEEENGTRREFDHLVFATNANTAAQLMTSL--PERESLMK----TLARV 302
Cdd:TIGR00562 227 LPEEIEKRLKLTKVYKGTKVTKLSHRGSNYTLELDNGVTVETDSVVVTAPHKAAAGLLSELsnSASSHLDKihspPVANV 306

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966513797  303 RYYDTQIAIHGDK---RFMPPKEKDWRVANVRYNGmnsamtiyKKWKSKTPVFKSWVTHDIRAPGDKG 367
Cdd:TIGR00562 307 NLGFPEGSVDGELegfGFLISRSSKFAILGCIFTS--------KLFPNRAPPGKTLLTAYIGGATDES 366
PRK07233 PRK07233
hypothetical protein; Provisional
 23-65 2.38e-06

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 49.50  E-value: 2.38e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 966513797  23 RIAIVGGGAAGVVSAW-LLEQDHEITLYESQDRLGGHANSINVE 65
Cdd:PRK07233   1 KIAIVGGGIAGLAAAYrLAKRGHEVTVFEADDQLGGLAASFEFG 44
PLN02487 PLN02487
zeta-carotene desaturase
 23-92 7.13e-05

zeta-carotene desaturase


Pssm-ID: 215268 [Multi-domain]  Cd Length: 569  Bit Score: 45.18  E-value: 7.13e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966513797  23 RIAIVGGGAAGVVSAW-LLEQDHEITLYESQDRLGGHANSInVEVDGKKIvvEAGAEFFnrFA-YPHFMRLL 92
Cdd:PLN02487  77 KVAIIGAGLAGMSTAVeLLDQGHEVDIYESRPFIGGKVGSF-VDKNGNHI--EMGLHVF--FGcYNNLFRLM 143
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 23-59 1.22e-04

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 43.93  E-value: 1.22e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 966513797   23 RIAIVGGGAAGVVSAW-LLEQDHEITLYESQDRLGGHA 59
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYeLARRGLSVTLLERGDDPGSGA 38
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
23-56 3.19e-04

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 43.02  E-value: 3.19e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 966513797  23 RIAIVGGGAAGVVSAW-LLEQDH---EITLYESQDRLG 56
Cdd:COG4529    7 RIAIIGGGASGTALAIhLLRRAPeplRITLFEPRPELG 44
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 23-57 3.61e-04

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 42.81  E-value: 3.61e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 966513797  23 RIAIVGGGAAGVVSAW-LLEQDHEITLYESQDRLGG 57
Cdd:COG0493  123 KVAVVGSGPAGLAAAYqLARAGHEVTVFEALDKPGG 158
PRK12814 PRK12814
putative NADPH-dependent glutamate synthase small subunit; Provisional
 23-57 4.05e-04

putative NADPH-dependent glutamate synthase small subunit; Provisional


Pssm-ID: 139246 [Multi-domain]  Cd Length: 652  Bit Score: 42.79  E-value: 4.05e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 966513797  23 RIAIVGGGAAGVVSAW-LLEQDHEITLYESQDRLGG 57
Cdd:PRK12814 195 KVAIIGAGPAGLTAAYyLLRKGHDVTIFDANEQAGG 230
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 23-57 8.36e-04

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 41.78  E-value: 8.36e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 966513797  23 RIAIVGGGAAGVVSAWLLE-QDHEITLYESQDRLGG 57
Cdd:PRK12771 139 RVAVIGGGPAGLSAAYHLRrMGHAVTIFEAGPKLGG 174
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 23-57 1.19e-03

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 40.93  E-value: 1.19e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 966513797  23 RIAIVGGGAAGVVSAWLL-EQDHEITLYESQDRLGG 57
Cdd:PRK11749 142 KVAVIGAGPAGLTAAHRLaRKGYDVTIFEARDKAGG 177
YhiN COG2081
Predicted flavoprotein YhiN [General function prediction only];
25-90 1.25e-03

Predicted flavoprotein YhiN [General function prediction only];


Pssm-ID: 441684 [Multi-domain]  Cd Length: 402  Bit Score: 40.80  E-value: 1.25e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966513797  25 AIVGGGAAGVVSA-WLLEQDHEITLYEsqdrlggHANSInvevdGKKIVV-----------EAGAEFFNRF-AYPHFMR 90
Cdd:COG2081    1 IVIGAGAAGLMAAiTAAERGARVLLLE-------KNPKV-----GRKILIsgggrcnftnsEPLPEFLNYYgGNPHFLK 67
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
23-59 1.50e-03

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 40.66  E-value: 1.50e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 966513797  23 RIAIVGGGAAGVVSAW-LLEQDHEITLYEsQDRLGGHA 59
Cdd:COG0665    4 DVVVIGGGIAGLSTAYhLARRGLDVTVLE-RGRPGSGA 40
YcjR COG1082
Sugar phosphate isomerase/epimerase [Carbohydrate transport and metabolism];
133-191 2.82e-03

Sugar phosphate isomerase/epimerase [Carbohydrate transport and metabolism];


Pssm-ID: 440699 [Multi-domain]  Cd Length: 254  Bit Score: 39.23  E-value: 2.82e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966513797 133 TPANLRKIM------NLKVVLDVGHHVIEEKDSTLTLEALAD---NIHITDVFKDTFLYPflaaGWGV 191
Cdd:COG1082  146 TPEEALRLLeavdspNVGLLLDTGHALLAGEDPVELLRKLGDrikHVHLKDADGDQHLPP----GEGD 209
PLN02576 PLN02576
protoporphyrinogen oxidase
 16-68 4.53e-03

protoporphyrinogen oxidase


Pssm-ID: 215314 [Multi-domain]  Cd Length: 496  Bit Score: 39.23  E-value: 4.53e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 966513797  16 HNAVWADRIAIVGGGAAGVVSAWLLEQDH--EITLYESQDRLGGhaNSINVEVDG 68
Cdd:PLN02576   7 SAAASSKDVAVVGAGVSGLAAAYALASKHgvNVLVTEARDRVGG--NITSVSEDG 59
PRK06522 PRK06522
2-dehydropantoate 2-reductase; Reviewed
 23-75 6.29e-03

2-dehydropantoate 2-reductase; Reviewed


Pssm-ID: 235821 [Multi-domain]  Cd Length: 304  Bit Score: 38.29  E-value: 6.29e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966513797  23 RIAIVGGGAAG-VVSAWLLEQDHEITLYesqDRLGGHANSINVE---VDGKKIVVEA 75
Cdd:PRK06522   2 KIAILGAGAIGgLFGAALAQAGHDVTLV---ARRGAHLDALNENglrLEDGEITVPV 55
PRK00711 PRK00711
D-amino acid dehydrogenase;
23-54 7.32e-03

D-amino acid dehydrogenase;


Pssm-ID: 234819 [Multi-domain]  Cd Length: 416  Bit Score: 38.63  E-value: 7.32e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 966513797  23 RIAIVGGGAAGVVSAWLLEQD-HEITLYESQDR 54
Cdd:PRK00711   2 RVVVLGSGVIGVTSAWYLAQAgHEVTVIDRQPG 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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