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Conserved domains on  [gi|966514159|ref|WP_058530678|]
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tryptophan--tRNA ligase [Legionella rubrilucens]

Protein Classification

tryptophan--tRNA ligase( domain architecture ID 10793629)

tryptophan--tRNA ligase is a class I tRNA synthetase and aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK12283 PRK12283
tryptophanyl-tRNA synthetase; Reviewed
 7-404 0e+00

tryptophanyl-tRNA synthetase; Reviewed


:

Pssm-ID: 183401 [Multi-domain]  Cd Length: 398  Bit Score: 839.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159   7 ASKRVVSGMRASGRLHLGHYHGVIKNWLKLQHQYDCYFFVADWHGLTTRYDEPGFIETILWDMVIDWLACGINPSLSKIF 86
Cdd:PRK12283   1 FPDRVLSGMRPTGRLHLGHYHGVLKNWVKLQHEYECFFFVADWHALTTHYETPEVIEKNVWDMVIDWLAAGVDPAQATLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  87 IQSWVPEHAELHLLLSMITPLGWLERVPTFKDQQEKLHEKDLATYGFLGYPLLQSADVLLYKADYVPVGEDQVAHIELTR 166
Cdd:PRK12283  81 IQSKVPEHAELHLLLSMITPLGWLERVPTYKDQQEKLKEKDLSTYGFLGYPLLQSADILIYRAGLVPVGEDQVPHVEMTR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 167 EVARRFNHIYGREPNFEALAMEAIKKMGKKNGSLYTELRRQFQQDGDHESLNTAKALLANQHNLSLGDKERLLGFLDGSG 246
Cdd:PRK12283 161 EIARRFNHLYGREPGFEEKAEAAIKKLGKKRAKLYHELRNAYQEEGDDEALEQARALLQEQQNLSMGDRERLFGYLEGAG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 247 KIILPEPHPLLTETSKMPGTDGQKMSKSYNNTISLREEPEQVEKKILTMPTDPARVKRTDPGEPEKCPVWQLHKIYSADD 326
Cdd:PRK12283 241 KIILPEPQALLTEASKMPGLDGQKMSKSYGNTIGLREDPESVTKKIRTMPTDPARVRRTDPGDPEKCPVWQLHQVYSDEE 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966514159 327 VKGWVQTGCRTAGIGCIECKRPVVDAIQQELKPLQAAIKDFEEDLGSVKRIVADGSEAAREEANKTLNDVREVMGLDY 404
Cdd:PRK12283 321 TKEWVQKGCRSAGIGCLECKQPVIDAILREQQPMRERAQKYEDDPSLVRAIVADGCEKARKVARETMRDVREAMGLSY 398
 
Name Accession Description Interval E-value
PRK12283 PRK12283
tryptophanyl-tRNA synthetase; Reviewed
 7-404 0e+00

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 183401 [Multi-domain]  Cd Length: 398  Bit Score: 839.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159   7 ASKRVVSGMRASGRLHLGHYHGVIKNWLKLQHQYDCYFFVADWHGLTTRYDEPGFIETILWDMVIDWLACGINPSLSKIF 86
Cdd:PRK12283   1 FPDRVLSGMRPTGRLHLGHYHGVLKNWVKLQHEYECFFFVADWHALTTHYETPEVIEKNVWDMVIDWLAAGVDPAQATLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  87 IQSWVPEHAELHLLLSMITPLGWLERVPTFKDQQEKLHEKDLATYGFLGYPLLQSADVLLYKADYVPVGEDQVAHIELTR 166
Cdd:PRK12283  81 IQSKVPEHAELHLLLSMITPLGWLERVPTYKDQQEKLKEKDLSTYGFLGYPLLQSADILIYRAGLVPVGEDQVPHVEMTR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 167 EVARRFNHIYGREPNFEALAMEAIKKMGKKNGSLYTELRRQFQQDGDHESLNTAKALLANQHNLSLGDKERLLGFLDGSG 246
Cdd:PRK12283 161 EIARRFNHLYGREPGFEEKAEAAIKKLGKKRAKLYHELRNAYQEEGDDEALEQARALLQEQQNLSMGDRERLFGYLEGAG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 247 KIILPEPHPLLTETSKMPGTDGQKMSKSYNNTISLREEPEQVEKKILTMPTDPARVKRTDPGEPEKCPVWQLHKIYSADD 326
Cdd:PRK12283 241 KIILPEPQALLTEASKMPGLDGQKMSKSYGNTIGLREDPESVTKKIRTMPTDPARVRRTDPGDPEKCPVWQLHQVYSDEE 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966514159 327 VKGWVQTGCRTAGIGCIECKRPVVDAIQQELKPLQAAIKDFEEDLGSVKRIVADGSEAAREEANKTLNDVREVMGLDY 404
Cdd:PRK12283 321 TKEWVQKGCRSAGIGCLECKQPVIDAILREQQPMRERAQKYEDDPSLVRAIVADGCEKARKVARETMRDVREAMGLSY 398
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 9-404 6.23e-172

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 483.40  E-value: 6.23e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159   9 KRVVSGMRASGRLHLGHYHGVIKNWLKLQHQYDCYFFVADWHGLTTRYDePGFIETILWDMVIDWLACGINPSLSKIFIQ 88
Cdd:COG0180    4 KRVLSGIQPTGRLHLGNYLGALKNWVELQDEYECFFFIADLHALTTPQD-PEELRENTREVAADYLAAGLDPEKSTIFVQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  89 SWVPEHAELHLLLSMITPLGWLERVPTFKDQQEKlHEKDLATYGFLGYPLLQSADVLLYKADYVPVGEDQVAHIELTREV 168
Cdd:COG0180   83 SDVPEHAELAWLLSCLTPLGELERMPQFKDKSAK-NGKENVNAGLLTYPVLMAADILLYKADLVPVGEDQKQHLELTRDI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 169 ARRFNHIYGRepnfealameaikkmgkkngslytelrrqfqqdgdheslntakallanqhnlslgdkerllgfldgsgki 248
Cdd:COG0180  162 ARRFNHRYGE---------------------------------------------------------------------- 171

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 249 ILPEPHPLLTE-TSKMPGTDGQ-KMSKSYNNTISLREEPEQVEKKILTMPTDPARVKRTDPGEPEKCPVWQLHKIYSADD 326
Cdd:COG0180  172 VFPEPEALIPEeGARIPGLDGRkKMSKSYGNTINLLDDPKEIRKKIKSAVTDSERLRYDDPGKPEVCNLFTIYSAFSGKE 251

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966514159 327 VKGWVQTGCRTAGIGCIECKRPVVDAIQQELKPLQAAIKDFEEDLGSVKRIVADGSEAAREEANKTLNDVREVMGLDY 404
Cdd:COG0180  252 EVEELEAEYRAGGIGYGDLKKALAEAVVEFLAPIRERRAELLADPAELDEILAEGAEKARAIAAKTLAEVREAMGLLY 329
TrpRS_core cd00806
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) ...
 10-356 3.56e-112

catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding


Pssm-ID: 173903 [Multi-domain]  Cd Length: 280  Bit Score: 329.54  E-value: 3.56e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  10 RVVSGMRASGRLHLGHYHGVIKNWLKLQH-QYDCYFFVADWHGLTTRYDEPGFIETILWDMVIDWLACGINPSLSKIFIQ 88
Cdd:cd00806    1 RVLSGIQPSGSLHLGHYLGAFRFWVWLQEaGYELFFFIADLHALTVKQLDPEELRQNTRENAKDYLACGLDPEKSTIFFQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  89 SWVPEHAELHLLLSMITPLGWLERVPTFKDqqeKLHEKDLATYGFLGYPLLQSADVLLYKADYVPVGEDQVAHIELTREV 168
Cdd:cd00806   81 SDVPEHYELAWLLSCVVTFGELERMTGFKD---KSAQGESVNIGLLTYPVLQAADILLYKACLVPVGIDQDPHLELTRDI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 169 ARRFNHIYGrepnfealameaikkmgkkngslytelrrqfqqdgdheslntakallanqhnlslgdkerllgfldgsgkI 248
Cdd:cd00806  158 ARRFNKLYG----------------------------------------------------------------------E 167

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 249 ILPEPHPLLTETSKMPGTDG--QKMSKSY-NNTISLREEPEQVEKKILTMPTDPAR-VKRTDPGEPEKCPVWQLHKIYSA 324
Cdd:cd00806  168 IFPKPAALLSKGAFLPGLQGpsKKMSKSDpNNAIFLTDSPKEIKKKIMKAATDGGRtEHRRDGGGPGVSNLVEIYSAFFN 247

                        330       340       350
                 ....*....|....*....|....*....|...
gi 966514159 325 DDVKGWVQ-TGCRTAGIGCIECKRPVVDAIQQE 356
Cdd:cd00806  248 DDDEELEEiDEYRSGGLGYGECKKLLAEAIQEF 280
trpS TIGR00233
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ...
 9-402 1.02e-93

tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272975 [Multi-domain]  Cd Length: 327  Bit Score: 284.22  E-value: 1.02e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159    9 KRVVSGMRASGRLHLGHYHGVIKNWLKLQHQYDCYFFVADWHGLTTRYDEPGFIETILWDMVIDWLACGINPSLSKIFIQ 88
Cdd:TIGR00233   3 FRVLTGIQPSGKMHLGHYLGAIQTKWLQQFGVELFICIADLHAITVKQTDPDALRKAREELAADYLAVGLDPEKTFIFLQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159   89 SWVPEHAELHLLLSMITPLGWLERVPTFKDQQeklhEKDLATYGFLGYPLLQSADVLLYKADYVPVGEDQVAHIELTREV 168
Cdd:TIGR00233  83 SDYPEHYELAWLLSCQVTFGELKRMTQFKDKS----QAENVPIGLLSYPVLQAADILLYQADLVPVGIDQDQHLELTRDL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  169 ARRFNHIYGRepnfealameaikkmgkkngslytelrrqfqqdgdheslntakallanqhnlslgdkerllgfldgsgki 248
Cdd:TIGR00233 159 AERFNKKFKN---------------------------------------------------------------------- 168

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  249 ILPEPHPLLTE-TSKMPGTDGQKMSKSY-NNTISLREEPEQVEKKILTMPTDPARV----KRTDPGEPEKCPVWQLHKIY 322
Cdd:TIGR00233 169 FFPKPESLISKfFPRLMGLSGKKMSKSDpNSAIFLTDTPKQIKKKIRKAATDGGRVtlfeHREKPGVPNLLVIYQYLSFF 248

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  323 SADDVK-GWVQTGCRTAGIGCIECKRPVVDAIQQELKPLQAAIKDFEEDLgsVKRIVADGSEAAREEANKTLNDVREVMG 401
Cdd:TIGR00233 249 LIDDDKlKEIYEAYKSGKLGYGECKKALIEVLQEFLKEIQERRAEIAEEI--LDKILEPGAKKARETANKTLADVYKAMG 326


                  .
gi 966514159  402 L 402
Cdd:TIGR00233 327 L 327
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
10-358 1.77e-55

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 184.79  E-value: 1.77e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159   10 RVVSGMRASGRLHLGHYhGVIKNWLKLQ-HQYDCYFFVADWHGLTTRYDEpGFIETIL-------WDMVIdWLACGINPS 81
Cdd:pfam00579   7 RVYSGIDPTGPLHLGYL-VPLMKLRQFQqAGHEVFFLIGDLHAIIGDPSK-SPERKLLsretvleNAIKA-QLACGLDPE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159   82 LSKIFIQSWVPEHAELHLLLSMITPLGWLERVPTFKDQQEKLHEKDLATYGFLGYPLLQSADVLLYKADYVPVGEDQVAH 161
Cdd:pfam00579  84 KAEIVNNSDWLEHLELAWLLRDLGKHFSLNRMLQFKDVKKRLEQGPGISLGEFTYPLLQAYDILLLKADLQPGGSDQWGN 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  162 IELTREVARRFNhiygrepnfealameaikkmgkkngslytelrrqfqqdgdheslntakallanqhnlslgdkerllgf 241
Cdd:pfam00579 164 IELGRDLARRFN-------------------------------------------------------------------- 175

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  242 ldgsgKIILPEPHPLLTETskMPGTDG-QKMSKSYNNT-ISLREEPEQVEKKILTMPTDPAR-VKRTDPGEPEKCP-VWQ 317
Cdd:pfam00579 176 -----KKIFKKPVGLTNPL--LTGLDGgKKMSKSAGNSaIFLDDDPESVYKKIQKAYTDPDReVRKDLKLFTFLSNeEIE 248

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 966514159  318 LHKIYSADDVKGWVQT---GCRTAGIGCIECKRPVVDAIQQELK 358
Cdd:pfam00579 249 ILEAELGKSPYREAEEllaREVTGLVHGGDLKKAAAEAVNKLLQ 292
 
Name Accession Description Interval E-value
PRK12283 PRK12283
tryptophanyl-tRNA synthetase; Reviewed
 7-404 0e+00

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 183401 [Multi-domain]  Cd Length: 398  Bit Score: 839.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159   7 ASKRVVSGMRASGRLHLGHYHGVIKNWLKLQHQYDCYFFVADWHGLTTRYDEPGFIETILWDMVIDWLACGINPSLSKIF 86
Cdd:PRK12283   1 FPDRVLSGMRPTGRLHLGHYHGVLKNWVKLQHEYECFFFVADWHALTTHYETPEVIEKNVWDMVIDWLAAGVDPAQATLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  87 IQSWVPEHAELHLLLSMITPLGWLERVPTFKDQQEKLHEKDLATYGFLGYPLLQSADVLLYKADYVPVGEDQVAHIELTR 166
Cdd:PRK12283  81 IQSKVPEHAELHLLLSMITPLGWLERVPTYKDQQEKLKEKDLSTYGFLGYPLLQSADILIYRAGLVPVGEDQVPHVEMTR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 167 EVARRFNHIYGREPNFEALAMEAIKKMGKKNGSLYTELRRQFQQDGDHESLNTAKALLANQHNLSLGDKERLLGFLDGSG 246
Cdd:PRK12283 161 EIARRFNHLYGREPGFEEKAEAAIKKLGKKRAKLYHELRNAYQEEGDDEALEQARALLQEQQNLSMGDRERLFGYLEGAG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 247 KIILPEPHPLLTETSKMPGTDGQKMSKSYNNTISLREEPEQVEKKILTMPTDPARVKRTDPGEPEKCPVWQLHKIYSADD 326
Cdd:PRK12283 241 KIILPEPQALLTEASKMPGLDGQKMSKSYGNTIGLREDPESVTKKIRTMPTDPARVRRTDPGDPEKCPVWQLHQVYSDEE 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966514159 327 VKGWVQTGCRTAGIGCIECKRPVVDAIQQELKPLQAAIKDFEEDLGSVKRIVADGSEAAREEANKTLNDVREVMGLDY 404
Cdd:PRK12283 321 TKEWVQKGCRSAGIGCLECKQPVIDAILREQQPMRERAQKYEDDPSLVRAIVADGCEKARKVARETMRDVREAMGLSY 398
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 9-404 6.23e-172

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 483.40  E-value: 6.23e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159   9 KRVVSGMRASGRLHLGHYHGVIKNWLKLQHQYDCYFFVADWHGLTTRYDePGFIETILWDMVIDWLACGINPSLSKIFIQ 88
Cdd:COG0180    4 KRVLSGIQPTGRLHLGNYLGALKNWVELQDEYECFFFIADLHALTTPQD-PEELRENTREVAADYLAAGLDPEKSTIFVQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  89 SWVPEHAELHLLLSMITPLGWLERVPTFKDQQEKlHEKDLATYGFLGYPLLQSADVLLYKADYVPVGEDQVAHIELTREV 168
Cdd:COG0180   83 SDVPEHAELAWLLSCLTPLGELERMPQFKDKSAK-NGKENVNAGLLTYPVLMAADILLYKADLVPVGEDQKQHLELTRDI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 169 ARRFNHIYGRepnfealameaikkmgkkngslytelrrqfqqdgdheslntakallanqhnlslgdkerllgfldgsgki 248
Cdd:COG0180  162 ARRFNHRYGE---------------------------------------------------------------------- 171

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 249 ILPEPHPLLTE-TSKMPGTDGQ-KMSKSYNNTISLREEPEQVEKKILTMPTDPARVKRTDPGEPEKCPVWQLHKIYSADD 326
Cdd:COG0180  172 VFPEPEALIPEeGARIPGLDGRkKMSKSYGNTINLLDDPKEIRKKIKSAVTDSERLRYDDPGKPEVCNLFTIYSAFSGKE 251

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966514159 327 VKGWVQTGCRTAGIGCIECKRPVVDAIQQELKPLQAAIKDFEEDLGSVKRIVADGSEAAREEANKTLNDVREVMGLDY 404
Cdd:COG0180  252 EVEELEAEYRAGGIGYGDLKKALAEAVVEFLAPIRERRAELLADPAELDEILAEGAEKARAIAAKTLAEVREAMGLLY 329
PRK00927 PRK00927
tryptophanyl-tRNA synthetase; Reviewed
 9-404 1.87e-151

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 234866 [Multi-domain]  Cd Length: 333  Bit Score: 431.43  E-value: 1.87e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159   9 KRVVSGMRASGRLHLGHYHGVIKNWLKLQHQYDCYFFVADWHGLTTRYDEPGFIETILwDMVIDWLACGINPSLSKIFIQ 88
Cdd:PRK00927   2 KRVLSGIQPTGKLHLGNYLGAIKNWVELQDEYECFFCIADLHALTVPQDPEELRENTR-ELAADYLACGIDPEKSTIFVQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  89 SWVPEHAELHLLLSMITPLGWLERVPTFKDQQEKlhEKDLATYGFLGYPLLQSADVLLYKADYVPVGEDQVAHIELTREV 168
Cdd:PRK00927  81 SHVPEHAELAWILNCITPLGELERMTQFKDKSAK--QKENVSAGLFTYPVLMAADILLYKADLVPVGEDQKQHLELTRDI 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 169 ARRFNHIYGRepnfealameaikkmgkkngslytelrrqfqqdgdheslntakallanqhnlslgdkerllgfldgsgki 248
Cdd:PRK00927 159 ARRFNNLYGE---------------------------------------------------------------------- 168

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 249 ILPEPHPLLTE-TSKMPGTDGQ--KMSKSY---NNTISLREEPEQVEKKILTMPTDPARVKRTDPGE---PEKCPVWQLH 319
Cdd:PRK00927 169 VFPVPEPLIPKvGARVMGLDGPtkKMSKSDpndNNTINLLDDPKTIAKKIKKAVTDSERLREIRYDLpnkPEVSNLLTIY 248

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 320 KIYSADDVKgWVQTGCRTAGIGCIECKRPVVDAIQQELKPLQAAIKDFEEDLGSVKRIVADGSEAAREEANKTLNDVREV 399
Cdd:PRK00927 249 SALSGESIE-ELEAEYEAGGKGYGDFKKDLAEAVVEFLAPIRERYEELLADPAYLDEILAEGAEKARAVASKTLKEVREA 327


                 ....*
gi 966514159 400 MGLDY 404
Cdd:PRK00927 328 MGLLR 332
TrpRS_core cd00806
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) ...
 10-356 3.56e-112

catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding


Pssm-ID: 173903 [Multi-domain]  Cd Length: 280  Bit Score: 329.54  E-value: 3.56e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  10 RVVSGMRASGRLHLGHYHGVIKNWLKLQH-QYDCYFFVADWHGLTTRYDEPGFIETILWDMVIDWLACGINPSLSKIFIQ 88
Cdd:cd00806    1 RVLSGIQPSGSLHLGHYLGAFRFWVWLQEaGYELFFFIADLHALTVKQLDPEELRQNTRENAKDYLACGLDPEKSTIFFQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  89 SWVPEHAELHLLLSMITPLGWLERVPTFKDqqeKLHEKDLATYGFLGYPLLQSADVLLYKADYVPVGEDQVAHIELTREV 168
Cdd:cd00806   81 SDVPEHYELAWLLSCVVTFGELERMTGFKD---KSAQGESVNIGLLTYPVLQAADILLYKACLVPVGIDQDPHLELTRDI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 169 ARRFNHIYGrepnfealameaikkmgkkngslytelrrqfqqdgdheslntakallanqhnlslgdkerllgfldgsgkI 248
Cdd:cd00806  158 ARRFNKLYG----------------------------------------------------------------------E 167

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 249 ILPEPHPLLTETSKMPGTDG--QKMSKSY-NNTISLREEPEQVEKKILTMPTDPAR-VKRTDPGEPEKCPVWQLHKIYSA 324
Cdd:cd00806  168 IFPKPAALLSKGAFLPGLQGpsKKMSKSDpNNAIFLTDSPKEIKKKIMKAATDGGRtEHRRDGGGPGVSNLVEIYSAFFN 247

                        330       340       350
                 ....*....|....*....|....*....|...
gi 966514159 325 DDVKGWVQ-TGCRTAGIGCIECKRPVVDAIQQE 356
Cdd:cd00806  248 DDDEELEEiDEYRSGGLGYGECKKLLAEAIQEF 280
PRK12282 PRK12282
tryptophanyl-tRNA synthetase II; Reviewed
 7-404 8.14e-111

tryptophanyl-tRNA synthetase II; Reviewed


Pssm-ID: 183400 [Multi-domain]  Cd Length: 333  Bit Score: 328.35  E-value: 8.14e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159   7 ASKRVVSGMRASGRLHLGHYHGVIKNWLKLQHQYDCYFFVADWHGLTTRYDEPGFIETILWDMVIDWLACGINPSLSKIF 86
Cdd:PRK12282   1 TKPIILTGDRPTGKLHLGHYVGSLKNRVALQNEHEQFVLIADQQALTDNAKNPEKIRRNILEVALDYLAVGIDPAKSTIF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  87 IQSWVPEHAELHLLLSMITPLGWLERVPTFKDQ-QEKLHEKDLaTYGFLGYPLLQSADVLLYKADYVPVGEDQVAHIELT 165
Cdd:PRK12282  81 IQSQIPELAELTMYYMNLVTVARLERNPTVKTEiAQKGFGRSI-PAGFLTYPVSQAADITAFKATLVPVGDDQLPMIEQT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 166 REVARRFNHIYGREpnfealameaikkmgkkngslytelrrqfqqdgdheslntakallanqhnlslgdkerllgfldgs 245
Cdd:PRK12282 160 REIVRRFNSLYGTD------------------------------------------------------------------ 173

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 246 gkiILPEPHPLLTETSKMPGTDGQ-KMSKSYNNTISLREEPEQVEKKILTMPTDPARVKRTDPGEPEKCPVWQLHKIYSA 324
Cdd:PRK12282 174 ---VLVEPEALLPEAGRLPGLDGKaKMSKSLGNAIYLSDDADTIKKKVMSMYTDPNHIRVEDPGKVEGNVVFTYLDAFDP 250

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 325 DDVKgwVQ---TGCRTAGIGCIECKRPVVDAIQQELKPLQAAIKDFEEDLGSVKRIVADGSEAAREEANKTLNDVREVMG 401
Cdd:PRK12282 251 DKAE--VAelkAHYQRGGLGDVKCKRYLEEVLQELLAPIRERRAEFAKDPGYVLEILKAGSEKAREVAAQTLSEVKDAMG 328


                 ...
gi 966514159 402 LDY 404
Cdd:PRK12282 329 LNY 331
trpS TIGR00233
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ...
 9-402 1.02e-93

tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272975 [Multi-domain]  Cd Length: 327  Bit Score: 284.22  E-value: 1.02e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159    9 KRVVSGMRASGRLHLGHYHGVIKNWLKLQHQYDCYFFVADWHGLTTRYDEPGFIETILWDMVIDWLACGINPSLSKIFIQ 88
Cdd:TIGR00233   3 FRVLTGIQPSGKMHLGHYLGAIQTKWLQQFGVELFICIADLHAITVKQTDPDALRKAREELAADYLAVGLDPEKTFIFLQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159   89 SWVPEHAELHLLLSMITPLGWLERVPTFKDQQeklhEKDLATYGFLGYPLLQSADVLLYKADYVPVGEDQVAHIELTREV 168
Cdd:TIGR00233  83 SDYPEHYELAWLLSCQVTFGELKRMTQFKDKS----QAENVPIGLLSYPVLQAADILLYQADLVPVGIDQDQHLELTRDL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  169 ARRFNHIYGRepnfealameaikkmgkkngslytelrrqfqqdgdheslntakallanqhnlslgdkerllgfldgsgki 248
Cdd:TIGR00233 159 AERFNKKFKN---------------------------------------------------------------------- 168

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  249 ILPEPHPLLTE-TSKMPGTDGQKMSKSY-NNTISLREEPEQVEKKILTMPTDPARV----KRTDPGEPEKCPVWQLHKIY 322
Cdd:TIGR00233 169 FFPKPESLISKfFPRLMGLSGKKMSKSDpNSAIFLTDTPKQIKKKIRKAATDGGRVtlfeHREKPGVPNLLVIYQYLSFF 248

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  323 SADDVK-GWVQTGCRTAGIGCIECKRPVVDAIQQELKPLQAAIKDFEEDLgsVKRIVADGSEAAREEANKTLNDVREVMG 401
Cdd:TIGR00233 249 LIDDDKlKEIYEAYKSGKLGYGECKKALIEVLQEFLKEIQERRAEIAEEI--LDKILEPGAKKARETANKTLADVYKAMG 326


                  .
gi 966514159  402 L 402
Cdd:TIGR00233 327 L 327
PLN02886 PLN02886
aminoacyl-tRNA ligase
 8-401 3.23e-84

aminoacyl-tRNA ligase


Pssm-ID: 215478 [Multi-domain]  Cd Length: 389  Bit Score: 262.06  E-value: 3.23e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159   8 SKRVVSGMRASGRLHLGHYHGVIKNWLKLQHQYDCYFFVADWHGLTTRYDEPGFIETILwDMVIDWLACGINPSLSKIFI 87
Cdd:PLN02886  46 KKRVVSGVQPTGSIHLGNYLGAIKNWVALQETYDTFFCVVDLHAITLPHDPRELGKATR-STAAIYLACGIDPSKASVFV 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  88 QSWVPEHAELHLLLSMITPLGWLERVPTFKDQQEKLHEKDLATyGFLGYPLLQSADVLLYKADYVPVGEDQVAHIELTRE 167
Cdd:PLN02886 125 QSHVPAHAELMWLLSCSTPIGWLNKMIQFKEKSRKAGDENVGV-GLLTYPVLMASDILLYQADLVPVGEDQKQHLELTRD 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 168 VARRFNHIYGREPnfealameaIKKMGKKNGSLYTelrrqfqqdgdheslntakallanqhnlslgdkerllgfldgsgk 247
Cdd:PLN02886 204 IAERVNNLYGGRK---------WKKLGGRGGSVFK--------------------------------------------- 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 248 iilpEPHPLLTETSK--MPGTDG-QKMSKSY---NNTISLREEPEQVEKKILTMPTDParVKRTDPGEPEKCPVWQLHKI 321
Cdd:PLN02886 230 ----VPEALIPPAGArvMSLTDGtSKMSKSApsdQSRINLLDPPDVIANKIKRCKTDS--FPGLEFDNPERPECNNLLSI 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 322 YSA--DDVKGWVQTGCRTAGIGCIecKRPVVDAIQQELKPLQAAIKDFEEDLGSVKRIVADGSEAAREEANKTLNDVREV 399
Cdd:PLN02886 304 YQLvtGKTKEEVLAECGDMRWGDF--KPLLTDALIEHLSPIQVRYEEIMSDPSYLDSVLKEGADAAAEIADRTLANVYQA 381


                 ..
gi 966514159 400 MG 401
Cdd:PLN02886 382 MG 383
PRK12556 PRK12556
tryptophanyl-tRNA synthetase; Provisional
 7-403 2.95e-64

tryptophanyl-tRNA synthetase; Provisional


Pssm-ID: 183592 [Multi-domain]  Cd Length: 332  Bit Score: 208.81  E-value: 2.95e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159   7 ASKRVVSGMRASGRLHLGHYHGVIKNWLKLQHQYDC--YFFVADWHGLTTRYDePGFIETILWDMVIDWLACGINPSLSK 84
Cdd:PRK12556   2 SEKIMLTGIKPTGYPHLGNYIGAIKPALQMAKNYEGkaLYFIADYHALNAVHD-PEQFRSYTREVAATWLSLGLDPEDVI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  85 IFIQSWVPEHAELHLLLSMITPLGWLERVPTFKDQQEKLHE--KDL---ATYGFLGYPLLQSADVLLYKADYVPVGEDQV 159
Cdd:PRK12556  81 FYRQSDVPEIFELAWILSCLTPKGLMNRAHAYKAKVDQNKEagLDLdagVNMGLYTYPILMAADILLFQATHVPVGKDQI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 160 AHIELTREVARRFNHIYGREPNFEalameaikkmgkkngslytelrrqfqqdgdheslntakallanqhnlslgdkerll 239
Cdd:PRK12556 161 QHIEIARDIATYFNHTFGDTFTLP-------------------------------------------------------- 184

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 240 gfldgsgKIILPEphplltETSKMPGTDGQKMSKSYNNTISLREEPEQVEKKILTMPTDPARVkrTDPGEPEKCPVWQLH 319
Cdd:PRK12556 185 -------EYVIQE------EGAILPGLDGRKMSKSYGNVIPLFAEQEKLRKLIFKIKTDSSLP--NEPKDPETSALFTIY 249

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 320 KIYSADDVKGWVQTGCRTaGIGCIECKRPVVDAIQQELKPLQAAIKDFEEDLGSVKRIVADGSEAAREEANKTLNDVREV 399
Cdd:PRK12556 250 KEFATEEEVQSMREKYET-GIGWGDVKKELFRVVDRELAGPREKYAMYMNEPSLLDEALEKGAERAREIAKPNLAEIKKA 328


                 ....
gi 966514159 400 MGLD 403
Cdd:PRK12556 329 IGFE 332
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
10-358 1.77e-55

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 184.79  E-value: 1.77e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159   10 RVVSGMRASGRLHLGHYhGVIKNWLKLQ-HQYDCYFFVADWHGLTTRYDEpGFIETIL-------WDMVIdWLACGINPS 81
Cdd:pfam00579   7 RVYSGIDPTGPLHLGYL-VPLMKLRQFQqAGHEVFFLIGDLHAIIGDPSK-SPERKLLsretvleNAIKA-QLACGLDPE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159   82 LSKIFIQSWVPEHAELHLLLSMITPLGWLERVPTFKDQQEKLHEKDLATYGFLGYPLLQSADVLLYKADYVPVGEDQVAH 161
Cdd:pfam00579  84 KAEIVNNSDWLEHLELAWLLRDLGKHFSLNRMLQFKDVKKRLEQGPGISLGEFTYPLLQAYDILLLKADLQPGGSDQWGN 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  162 IELTREVARRFNhiygrepnfealameaikkmgkkngslytelrrqfqqdgdheslntakallanqhnlslgdkerllgf 241
Cdd:pfam00579 164 IELGRDLARRFN-------------------------------------------------------------------- 175

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  242 ldgsgKIILPEPHPLLTETskMPGTDG-QKMSKSYNNT-ISLREEPEQVEKKILTMPTDPAR-VKRTDPGEPEKCP-VWQ 317
Cdd:pfam00579 176 -----KKIFKKPVGLTNPL--LTGLDGgKKMSKSAGNSaIFLDDDPESVYKKIQKAYTDPDReVRKDLKLFTFLSNeEIE 248

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 966514159  318 LHKIYSADDVKGWVQT---GCRTAGIGCIECKRPVVDAIQQELK 358
Cdd:pfam00579 249 ILEAELGKSPYREAEEllaREVTGLVHGGDLKKAAAEAVNKLLQ 292
PRK12284 PRK12284
tryptophanyl-tRNA synthetase; Reviewed
 10-402 4.14e-48

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 237036 [Multi-domain]  Cd Length: 431  Bit Score: 169.41  E-value: 4.14e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  10 RVVSGMRASGRLHLGHYHGVIKNWLK--LQHQYDCYFFVADWHGLTtRYDEPGFIETILWDMVIDWLACGINPSLSKIFI 87
Cdd:PRK12284   4 RVLTGITTTGTPHLGNYAGAIRPAIAasRQPGVESFYFLADYHALI-KCDDPARIQRSTLEIAATWLAAGLDPERVTFYR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  88 QSWVPEHAELHLLLSMITPLGWLERVPTFKDQQEKLHEK-----DLATYGFLGYPLLQSADVLLYKADYVPVGEDQVAHI 162
Cdd:PRK12284  83 QSDIPEIPELTWLLTCVAGKGLLNRAHAYKAAVDKNVAAgedpdAGVTAGLFMYPVLMAADILMFNAHKVPVGRDQIQHI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 163 ELTREVARRFNHIYGREpnFEALAMEAIKkmgkkngslytelrrqfqqdgdhESLNTakallanqhnlslgdkerllgfl 242
Cdd:PRK12284 163 EMARDIAQRFNHLYGGE--FFVLPEAVIE-----------------------ESVAT----------------------- 194

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 243 dgsgkiilpephplltetskMPGTDGQKMSKSYNNTISLREEPEQVEKKILTMPTDpARVkrtdPGEP---EKCPVWQLH 319
Cdd:PRK12284 195 --------------------LPGLDGRKMSKSYDNTIPLFAPREELKKAIFSIVTD-SRA----PGEPkdtEGSALFQLY 249

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 320 KIYSADDvkgwvQT-GCRTA---GIGCIECKRPVVDAIQQELKPLQAAIKDFEEDLGSVKRIVADGSEAAREEANKTLND 395
Cdd:PRK12284 250 QAFATPE-----ETaAFRQAladGIGWGDAKQRLFERIDRELAPMRERYEALIARPADIEDILLAGAAKARRIATPFLAE 324


                 ....*..
gi 966514159 396 VREVMGL 402
Cdd:PRK12284 325 LREAVGL 331
PRK12285 PRK12285
tryptophanyl-tRNA synthetase; Reviewed
 11-398 5.90e-21

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 237037 [Multi-domain]  Cd Length: 368  Bit Score: 93.39  E-value: 5.90e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  11 VVSGMRASGRLHLGHYHGVIK-NWLKlQHQYDCYFFVADwhglttryDEPGFIETILWDMVIDW--------LACGINPS 81
Cdd:PRK12285  69 VYTGFMPSGPMHIGHKMVFDElKWHQ-EFGANVYIPIAD--------DEAYAARGLSWEETREWayeyildlIALGFDPD 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  82 LSKIFIQSwvpEHAELHlllSMITPLGwlERVpTFKDQQeklhekdlATYGFLG--------YPLLQSADVLLYKADY-- 151
Cdd:PRK12285 140 KTEIYFQS---ENIKVY---DLAFELA--KKV-NFSELK--------AIYGFTGetnighifYPATQAADILHPQLEEgp 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 152 ----VPVGEDQVAHIELTREVARRFNHIYGRepnfealameaikkmgKKNGSLYtelrrqfqqdgdheslntakallanq 227
Cdd:PRK12285 203 kptlVPVGIDQDPHIRLTRDIAERLHGGYGF----------------IKPSSTY-------------------------- 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 228 HNLslgdkerllgfldgsgkiilpephplltetskMPGTDGQKMSKSYNNT-ISLREEPEQVEKKILTMPT---DPARVK 303
Cdd:PRK12285 241 HKF--------------------------------MPGLTGGKMSSSKPESaIYLTDDPETVKKKIMKALTggrATLEEQ 288

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 304 RTDPGEPEKCPVWQLHKIYSADDVKGW--VQTGCRTAGIGCIECKRPVVDAIQQELKPLQAaikdfeedlgsvKRivadg 381
Cdd:PRK12285 289 RKLGGEPDECVVYELLLYHLEEDDKELkeIYEECRSGELLCGECKKEAAEKIAEFLKEHQE------------KR----- 351

                        410
                 ....*....|....*..
gi 966514159 382 sEAAREEANKTLNDVRE 398
Cdd:PRK12285 352 -EEAREILEKYLYDGKL 367
Tyr_Trp_RS_core cd00395
catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Tyrosinyl-tRNA ...
 13-195 1.94e-17

catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS)/Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. These enzymes attach Tyr or Trp, respectively, to the appropriate tRNA. These class I enzymes are homodimers, which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173893 [Multi-domain]  Cd Length: 273  Bit Score: 81.58  E-value: 1.94e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  13 SGMRASGR-LHLGHYHGvIKNWLKLQH-QYDCYFFVADWHGLT---------TRYDEPGFIETILWDMVIDWLACGI--N 79
Cdd:cd00395    4 CGIDPTADsLHIGHLIG-LLTFRRFQHaGHRPIFLIGGQTGIIgdpsgkkseRTLNDPEEVRQNIRRIAAQYLAVGIfeD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  80 PSLSKIFIQSWVP---EHAELHLLLSMITPLGWLERVPTFkdqQEKLHEKdlATYGFLGYPLLQSADVLLY----KADYV 152
Cdd:cd00395   83 PTQATLFNNSDWPgplAHIQFLRDLGKHVYVNYMERKTSF---QSRSEEG--ISATEFTYPPLQAADFLLLntteGCDIQ 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 966514159 153 PVGEDQVAHIELTREVARRFN---HIYGREPnfeALAMEAI-KKMGK 195
Cdd:cd00395  158 PGGSDQWGNITLGRELARRFNgftIAEGLTI---PLVTKLDgPKFGK 201
class_I_aaRS_core cd00802
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ...
 11-195 1.39e-04

catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173901 [Multi-domain]  Cd Length: 143  Bit Score: 41.70  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  11 VVSGMRASGRLHLGHYHG-----VIKNWL-KLQHQYDCYFFVADWHGlttrydepgfietilwdmVIDWLAcGINPSLSK 84
Cdd:cd00802    2 TFSGITPNGYLHIGHLRTivtfdFLAQAYrKLGYKVRCIALIDDAGG------------------LIGDPA-NKKGENAK 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159  85 IFIQSWVpehaelhlllsmitplgwlervptfkdqqEKLHEKdlatygfLGYPLLQSADVLL---YKADYVPVGEDQVAH 161
Cdd:cd00802   63 AFVERWI-----------------------------ERIKED-------VEYMFLQAADFLLlyeTECDIHLGGSDQLGH 106

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 966514159 162 IELTREVARRFN---HIYGREPNFeaLAMEAIKKMGK 195
Cdd:cd00802  107 IELGLELLKKAGgpaRPFGLTFGR--VMGADGTKMSK 141
TyrRS_core cd00805
catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) ...
 184-300 1.87e-04

catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) catalytic core domain. TyrRS is a homodimer which attaches Tyr to the appropriate tRNA. TyrRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formationof the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173902 [Multi-domain]  Cd Length: 269  Bit Score: 42.98  E-value: 1.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966514159 184 ALAMEAIK-KMGKKNGSLYTELRRQFQQDGDHESLNTA---------KALLANQHNL-SLGDKERLlGFLdgsgkiilpe 252
Cdd:cd00805  116 MLRRDAVKvRLEEEEGISFSEFIYPLLQAYDFVYLDVDlqlggsdqrGNITLGRDLIrKLGYKKVV-GLT---------- 184

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 966514159 253 pHPLLTetskmpGTDGQKMSKSYNNTI--SLREEPEQVEKKILTMPTDPA 300
Cdd:cd00805  185 -TPLLT------GLDGGKMSKSEGNAIwdPVLDSPYDVYQKIRNAFDPDV 227
TyrS COG0162
Tyrosyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tyrosyl-tRNA ...
 255-284 2.04e-03

Tyrosyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tyrosyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439932 [Multi-domain]  Cd Length: 409  Bit Score: 40.02  E-value: 2.04e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 966514159 255 PLLTetskmpGTDGQKMSKSYNNTISLREE 284
Cdd:COG0162  219 PLLT------GADGTKMGKSEGNAIWLDEE 242
PRK08560 PRK08560
tyrosyl-tRNA synthetase; Validated
 254-292 5.14e-03

tyrosyl-tRNA synthetase; Validated


Pssm-ID: 236286 [Multi-domain]  Cd Length: 329  Bit Score: 38.69  E-value: 5.14e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 966514159 254 HPLLtetskmPGTDG--QKMSKS-YNNTISLREEPEQVEKKI 292
Cdd:PRK08560 202 TPLL------TGLDGggIKMSKSkPGSAIFVHDSPEEIRRKI 237
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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