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Conserved domains on  [gi|968124819|ref|WP_058565837|]
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metal-dependent transcriptional regulator [Haloferax marisrubri]

Protein Classification

metal-dependent transcriptional regulator( domain architecture ID 11442491)

metal-dependent transcriptional regulator may be activated by one or more from a variety of metal ions such as Mn, Cd, Co, Ni, and Fe, among others, and may function as an activator or repressor of gene expression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
1-134 9.30e-67

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


:

Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 201.97  E-value: 9.30e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968124819   1 MLSDVMEDYLKAIYTLQmEQGPPVSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREKYKGVELTTEGETVALEVLRHHRL 80
Cdd:COG1321    3 MLSESEEDYLKAIYELS-EEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALRIVRRHRL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 968124819  81 LEAYLTEHLDYSWSEVHDEADALEHHISEEFEKRVAAALGEPEVDPHGDPIPSA 134
Cdd:COG1321   82 LERFLVEVLGVDWDEAHEEAERLEHVLSDETIERLDAFLGFPEEDPHGDPIPDA 135
FeoA smart00899
This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found ...
 147-219 2.37e-17

This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; This domain also occurs at the C-terminus in related proteins. The transporter Feo is composed of three proteins: FeoA a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. Feo allows the bacterial cell to acquire iron from its environment.


:

Pssm-ID: 214896  Cd Length: 72  Bit Score: 73.37  E-value: 2.37e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 968124819   147 LSDCEVGDHLVVARVSDRDPAELEYLSEAGVTPGTTIEVTDIAPFGMVTVRVGDggrEQSLPESVARTIRVRP 219
Cdd:smart00899   3 LSELKPGEKARIVRIRDEDPELLRRLLELGLVPGTEVTVLRKAPFGPLVVRVGG---ELALRREEAEKIFVEP 72
 
Name Accession Description Interval E-value
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
1-134 9.30e-67

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 201.97  E-value: 9.30e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968124819   1 MLSDVMEDYLKAIYTLQmEQGPPVSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREKYKGVELTTEGETVALEVLRHHRL 80
Cdd:COG1321    3 MLSESEEDYLKAIYELS-EEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALRIVRRHRL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 968124819  81 LEAYLTEHLDYSWSEVHDEADALEHHISEEFEKRVAAALGEPEVDPHGDPIPSA 134
Cdd:COG1321   82 LERFLVEVLGVDWDEAHEEAERLEHVLSDETIERLDAFLGFPEEDPHGDPIPDA 135
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 26-120 1.14e-31

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 111.54  E-value: 1.14e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968124819    26 TSDIAEYLGKTPPTVTSMVGKLEDRGLVDREKYKGVELTTEGETVALEVLRHHRLLEAYLTEHLDYSWSEVHDEADALEH 105
Cdd:smart00529   1 TSEIAERLNVSPPTVTEMLKKLEKMGLVEYEPYRGITLTEKGRRLARRLLRKHRLLERFLVDVLGVDEEEVHEEAERLEH 80

                           90
                   ....*....|....*
gi 968124819   106 HISEEFEKRVAAALG 120
Cdd:smart00529  81 VLSDELEDRLDRFLG 95
Fe_dep_repr_C pfam02742
Iron dependent repressor, metal binding and dimerization domain; This family includes the ...
 64-132 3.36e-31

Iron dependent repressor, metal binding and dimerization domain; This family includes the Diphtheria toxin repressor. It acts as an iron-binding repressor of diphtheria toxin gene expression and may serve as a global regulator of gene expression. DTXR comprises an N-terminal DNA-binding domain, an interface domain (which contains two metal-binding sites) and a third, very flexible C-terminal domain. The second domain is responsible for dimerization and metal binding. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation. This domain can also bind Cd(II), Ca(II) and Cu(II) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426954  Cd Length: 69  Bit Score: 109.48  E-value: 3.36e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 968124819   64 TTEGETVALEVLRHHRLLEAYLTEHLDYSWSEVHDEADALEHHISEEFEKRVAAALGEPEVDPHGDPIP 132
Cdd:pfam02742   1 TEKGRKIALRVVRRHRLLERFLVDVLGVDWDEVHEEAERLEHALSDELIDRLDEFLGFPETCPHGDPIP 69
PRK03902 PRK03902
transcriptional regulator MntR;
1-108 2.26e-17

transcriptional regulator MntR;


Pssm-ID: 179669 [Multi-domain]  Cd Length: 142  Bit Score: 75.80  E-value: 2.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968124819   1 MLSDVMEDYLKAIYTLQMEQGPpVSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREKYKGVELTTEGETVALEVLRHHRL 80
Cdd:PRK03902   1 MPTPSMEDYIEQIYLLIEEKGY-ARVSDIAEALSVHPSSVTKMVQKLDKDEYLIYEKYRGLVLTPKGKKIGKRLVYRHEL 79

                         90       100
                 ....*....|....*....|....*...
gi 968124819  81 LEAYLTeHLDYSWSEVHDEADALEHHIS 108
Cdd:PRK03902  80 LEQFLR-IIGVDESKIYNDVEGIEHHLS 106
FeoA smart00899
This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found ...
 147-219 2.37e-17

This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; This domain also occurs at the C-terminus in related proteins. The transporter Feo is composed of three proteins: FeoA a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. Feo allows the bacterial cell to acquire iron from its environment.


Pssm-ID: 214896  Cd Length: 72  Bit Score: 73.37  E-value: 2.37e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 968124819   147 LSDCEVGDHLVVARVSDRDPAELEYLSEAGVTPGTTIEVTDIAPFGMVTVRVGDggrEQSLPESVARTIRVRP 219
Cdd:smart00899   3 LSELKPGEKARIVRIRDEDPELLRRLLELGLVPGTEVTVLRKAPFGPLVVRVGG---ELALRREEAEKIFVEP 72
FeoA pfam04023
FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. ...
 147-219 2.47e-17

FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.


Pssm-ID: 461133  Cd Length: 74  Bit Score: 73.39  E-value: 2.47e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 968124819  147 LSDCEVGDHLVVARVSDRDPAELEYLSEAGVTPGTTIEVTDIAPF-GMVTVRVgdGGREQSLPESVARTIRVRP 219
Cdd:pfam04023   3 LSELKEGETARIVRIRDGDPELLRRLLELGLVPGAEVTVVRKAPFgGPIIVRV--GGTRIALRREEASKIFVEP 74
FeoA COG1918
Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];
147-219 2.17e-11

Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];


Pssm-ID: 441522  Cd Length: 73  Bit Score: 57.84  E-value: 2.17e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 968124819 147 LSDCEVGDHLVVARVSDrDPAELEYLSEAGVTPGTTIEVTDIAPF-GMVTVRVgdGGREQSLPESVARTIRVRP 219
Cdd:COG1918    3 LSELKPGEKARIVRISG-DGELRRRLLELGLVPGTEVEVVRKAPLgGPLVVRV--GGTRIALRREEAAKILVEP 73
HTH_CRP cd00092
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 9-64 1.42e-06

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


Pssm-ID: 238044 [Multi-domain]  Cd Length: 67  Bit Score: 44.58  E-value: 1.42e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 968124819   9 YLKAIYTLQMEQGPPVSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREKYKGVELT 64
Cdd:cd00092   11 NLSLRYGAGDLVQLPLTRQEIADYLGLTRETVSRTLKELEEEGLISRRGRGKYRVN 66
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 24-60 3.72e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 37.34  E-value: 3.72e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 968124819   24 VSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREKYKG 60
Cdd:TIGR01884 158 KSVKNIAKKLGKSLSTISRHLAELEKKGLVEQKGRKG 194
 
Name Accession Description Interval E-value
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
1-134 9.30e-67

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 201.97  E-value: 9.30e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968124819   1 MLSDVMEDYLKAIYTLQmEQGPPVSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREKYKGVELTTEGETVALEVLRHHRL 80
Cdd:COG1321    3 MLSESEEDYLKAIYELS-EEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALRIVRRHRL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 968124819  81 LEAYLTEHLDYSWSEVHDEADALEHHISEEFEKRVAAALGEPEVDPHGDPIPSA 134
Cdd:COG1321   82 LERFLVEVLGVDWDEAHEEAERLEHVLSDETIERLDAFLGFPEEDPHGDPIPDA 135
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 26-120 1.14e-31

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 111.54  E-value: 1.14e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968124819    26 TSDIAEYLGKTPPTVTSMVGKLEDRGLVDREKYKGVELTTEGETVALEVLRHHRLLEAYLTEHLDYSWSEVHDEADALEH 105
Cdd:smart00529   1 TSEIAERLNVSPPTVTEMLKKLEKMGLVEYEPYRGITLTEKGRRLARRLLRKHRLLERFLVDVLGVDEEEVHEEAERLEH 80

                           90
                   ....*....|....*
gi 968124819   106 HISEEFEKRVAAALG 120
Cdd:smart00529  81 VLSDELEDRLDRFLG 95
Fe_dep_repr_C pfam02742
Iron dependent repressor, metal binding and dimerization domain; This family includes the ...
 64-132 3.36e-31

Iron dependent repressor, metal binding and dimerization domain; This family includes the Diphtheria toxin repressor. It acts as an iron-binding repressor of diphtheria toxin gene expression and may serve as a global regulator of gene expression. DTXR comprises an N-terminal DNA-binding domain, an interface domain (which contains two metal-binding sites) and a third, very flexible C-terminal domain. The second domain is responsible for dimerization and metal binding. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation. This domain can also bind Cd(II), Ca(II) and Cu(II) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426954  Cd Length: 69  Bit Score: 109.48  E-value: 3.36e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 968124819   64 TTEGETVALEVLRHHRLLEAYLTEHLDYSWSEVHDEADALEHHISEEFEKRVAAALGEPEVDPHGDPIP 132
Cdd:pfam02742   1 TEKGRKIALRVVRRHRLLERFLVDVLGVDWDEVHEEAERLEHALSDELIDRLDEFLGFPETCPHGDPIP 69
PRK03902 PRK03902
transcriptional regulator MntR;
1-108 2.26e-17

transcriptional regulator MntR;


Pssm-ID: 179669 [Multi-domain]  Cd Length: 142  Bit Score: 75.80  E-value: 2.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968124819   1 MLSDVMEDYLKAIYTLQMEQGPpVSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREKYKGVELTTEGETVALEVLRHHRL 80
Cdd:PRK03902   1 MPTPSMEDYIEQIYLLIEEKGY-ARVSDIAEALSVHPSSVTKMVQKLDKDEYLIYEKYRGLVLTPKGKKIGKRLVYRHEL 79

                         90       100
                 ....*....|....*....|....*...
gi 968124819  81 LEAYLTeHLDYSWSEVHDEADALEHHIS 108
Cdd:PRK03902  80 LEQFLR-IIGVDESKIYNDVEGIEHHLS 106
FeoA smart00899
This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found ...
 147-219 2.37e-17

This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; This domain also occurs at the C-terminus in related proteins. The transporter Feo is composed of three proteins: FeoA a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. Feo allows the bacterial cell to acquire iron from its environment.


Pssm-ID: 214896  Cd Length: 72  Bit Score: 73.37  E-value: 2.37e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 968124819   147 LSDCEVGDHLVVARVSDRDPAELEYLSEAGVTPGTTIEVTDIAPFGMVTVRVGDggrEQSLPESVARTIRVRP 219
Cdd:smart00899   3 LSELKPGEKARIVRIRDEDPELLRRLLELGLVPGTEVTVLRKAPFGPLVVRVGG---ELALRREEAEKIFVEP 72
FeoA pfam04023
FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. ...
 147-219 2.47e-17

FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.


Pssm-ID: 461133  Cd Length: 74  Bit Score: 73.39  E-value: 2.47e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 968124819  147 LSDCEVGDHLVVARVSDRDPAELEYLSEAGVTPGTTIEVTDIAPF-GMVTVRVgdGGREQSLPESVARTIRVRP 219
Cdd:pfam04023   3 LSELKEGETARIVRIRDGDPELLRRLLELGLVPGAEVTVVRKAPFgGPIIVRV--GGTRIALRREEASKIFVEP 74
Fe_dep_repress pfam01325
Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria ...
 4-61 5.22e-17

Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif.


Pssm-ID: 396062 [Multi-domain]  Cd Length: 57  Bit Score: 72.40  E-value: 5.22e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 968124819    4 DVMEDYLKAIYTLQMEQGPpVSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREKYKGV 61
Cdd:pfam01325   1 ESTEDYLETIYTLSEEKGV-VKTKDLAERLNVSPSTVSEMLKKLEKMGYVDYEPYKGL 57
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
3-110 1.01e-14

manganese-binding transcriptional regulator MntR;


Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 68.88  E-value: 1.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968124819   3 SDVMEDYLKAIYTLqMEQGPPVSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREKYKGVELTTEGETVALEVLRHHRLLE 82
Cdd:PRK11050  32 RELIEDYVELIADL-IAEVGEARQVDIAARLGVSQPTVAKMLKRLARDGLVEMRPYRGVFLTPEGEKLAQESRERHQIVE 110

                         90       100       110
                 ....*....|....*....|....*....|
gi 968124819  83 AYLtehLDYSWSEVHDEADA--LEHHISEE 110
Cdd:PRK11050 111 NFL---LALGVSPETARRDAegIEHHVSEE 137
FeoA COG1918
Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];
147-219 2.17e-11

Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];


Pssm-ID: 441522  Cd Length: 73  Bit Score: 57.84  E-value: 2.17e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 968124819 147 LSDCEVGDHLVVARVSDrDPAELEYLSEAGVTPGTTIEVTDIAPF-GMVTVRVgdGGREQSLPESVARTIRVRP 219
Cdd:COG1918    3 LSELKPGEKARIVRISG-DGELRRRLLELGLVPGTEVEVVRKAPLgGPLVVRV--GGTRIALRREEAAKILVEP 73
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
20-90 4.04e-11

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 58.83  E-value: 4.04e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 968124819  20 QGPPVSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREK------YKGVELTTEGETVALEVLRHHRLLEAYLTEHLD 90
Cdd:COG1846   49 EAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPdpedrrAVLVRLTEKGRALLEEARPALEALLAELLAGLS 125
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
22-83 3.55e-08

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 49.90  E-value: 3.55e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 968124819    22 PPVSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREKYKG------VELTTEGETVALEVLRHHRLLEA 83
Cdd:smart00347  23 GPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEdrrsvlVSLTEEGRELIEQLLEARSETLA 90
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
23-117 1.63e-07

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 50.66  E-value: 1.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968124819  23 PVSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREKyKGVELTTEGETVALEVLRHHRLLEaYLTEHLDYsWSEvHDeada 102
Cdd:COG4742   29 PKTRSELAESLDVSRSTILRQLKELEERGLIERDD-GEYELTTLGRLVVEEMEPLLDTLE-VLEENRDY-WET-HD---- 100

                         90
                 ....*....|....*
gi 968124819 103 lEHHISEEFEKRVAA 117
Cdd:COG4742  101 -LSAIPPELLLRIGE 114
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
22-57 1.18e-06

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 46.80  E-value: 1.18e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 968124819  22 PPVSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREK 57
Cdd:COG3398  110 PGATNKELAEELGISRSTVSWHLKRLEEDGLVERER 145
HTH_CRP cd00092
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 9-64 1.42e-06

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


Pssm-ID: 238044 [Multi-domain]  Cd Length: 67  Bit Score: 44.58  E-value: 1.42e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 968124819   9 YLKAIYTLQMEQGPPVSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREKYKGVELT 64
Cdd:cd00092   11 NLSLRYGAGDLVQLPLTRQEIADYLGLTRETVSRTLKELEEEGLISRRGRGKYRVN 66
HTH_CRP smart00419
helix_turn_helix, cAMP Regulatory protein;
22-57 2.28e-06

helix_turn_helix, cAMP Regulatory protein;


Pssm-ID: 128696 [Multi-domain]  Cd Length: 48  Bit Score: 43.20  E-value: 2.28e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 968124819    22 PPVSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREK 57
Cdd:smart00419   7 LPLTRQEIAELLGLTRETVSRTLKRLEKEGLISREG 42
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 22-57 3.97e-06

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 42.92  E-value: 3.97e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 968124819   22 PPVSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREK 57
Cdd:pfam01047  16 GPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSR 51
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 16-56 5.33e-06

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 42.58  E-value: 5.33e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 968124819   16 LQMEQGPPVSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDRE 56
Cdd:pfam12802  12 LALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVERE 52
HrcA_DNA-bdg pfam03444
Winged helix-turn-helix transcription repressor, HrcA DNA-binding; This domain is always found ...
 1-54 1.04e-05

Winged helix-turn-helix transcription repressor, HrcA DNA-binding; This domain is always found with a pair of CBS domains pfam00571.


Pssm-ID: 281443 [Multi-domain]  Cd Length: 79  Bit Score: 42.32  E-value: 1.04e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 968124819    1 MLSDVMEDYLKAIYTLQMEQGPPVSTSDIAEYLGKTPPTVTSMVGKLEDRGLVD 54
Cdd:pfam03444   1 ELTPVQKEILQALINLYRKKGRAVKGEEIADIIGRNPGTVRNQMQSLKALGLVE 54
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 11-69 4.26e-05

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 40.67  E-value: 4.26e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 968124819  11 KAIYTLQMEQGPPVSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREK---YKGVELTTEGET 69
Cdd:COG2512   18 RRVLELLRENGGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKERvgrENVVELPEDEPE 79
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 23-57 1.58e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 39.20  E-value: 1.58e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 968124819  23 PVSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREK 57
Cdd:cd00090   20 PLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRR 54
HTH_Crp_2 pfam13545
Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain ...
 23-57 2.79e-04

Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain that is likely to bind DNA.


Pssm-ID: 463917 [Multi-domain]  Cd Length: 68  Bit Score: 38.21  E-value: 2.79e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 968124819   23 PVSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREK 57
Cdd:pfam13545  22 PLTQEDLADLLGTTRETVSRVLSELRREGLIERGR 56
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
13-57 3.45e-04

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 39.18  E-value: 3.45e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 968124819  13 IYTLQMEQGPPVSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREK 57
Cdd:COG3355   32 VYLILLENGEPLTVEELAEALDRSRSTVYRSLQKLLEAGLVEREK 76
LysR COG0583
DNA-binding transcriptional regulator, LysR family [Transcription];
30-87 7.02e-04

DNA-binding transcriptional regulator, LysR family [Transcription];


Pssm-ID: 440348 [Multi-domain]  Cd Length: 256  Bit Score: 39.85  E-value: 7.02e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 968124819  30 AEYLGKTPPTVTSMVGKLEDR-G--LVDREKyKGVELTTEGETV---ALEVLRHHRLLEAYLTE 87
Cdd:COG0583   22 AERLGVSQPAVSRQIRRLEEElGvpLFERTG-RGLRLTEAGERLlerARRILAELEEAEAELRA 84
HTH_1 pfam00126
Bacterial regulatory helix-turn-helix protein, lysR family;
30-68 7.73e-04

Bacterial regulatory helix-turn-helix protein, lysR family;


Pssm-ID: 459683 [Multi-domain]  Cd Length: 60  Bit Score: 36.59  E-value: 7.73e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 968124819   30 AEYLGKTPPTVTSMVGKLEDR-G--LVDReKYKGVELTTEGE 68
Cdd:pfam00126  20 AERLGLSQPAVSRQIKRLEEElGvpLFER-TTRGVRLTEAGE 60
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
21-57 1.53e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 36.03  E-value: 1.53e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 968124819    21 GPPVSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREK 57
Cdd:smart00418   8 EGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRR 44
CasRa_I-A cd09655
CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly ...
 24-60 1.70e-03

CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Predicted transcriptional regulator of CRISPR/Cas system


Pssm-ID: 187786 [Multi-domain]  Cd Length: 198  Bit Score: 38.13  E-value: 1.70e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 968124819  24 VSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREKYKG 60
Cdd:cd09655  154 KSVKNIAKKLGKSLSTISRHLRELEKKGLVEQKGTKG 190
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 23-57 2.03e-03

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 38.04  E-value: 2.03e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 968124819  23 PVSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREK 57
Cdd:COG0664  158 PLTQEEIASYLGLTRETVSRILKKLEKEGLIELER 192
Crp pfam00325
Bacterial regulatory proteins, crp family;
23-53 3.09e-03

Bacterial regulatory proteins, crp family;


Pssm-ID: 425608  Cd Length: 32  Bit Score: 34.20  E-value: 3.09e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 968124819   23 PVSTSDIAEYLGKTPPTVTSMVGKLEDRGLV 53
Cdd:pfam00325   2 RMSRQDIANYLGLTRETVSRVLGKLQEKGLI 32
pheS PRK04172
phenylalanine--tRNA ligase subunit alpha;
25-83 3.29e-03

phenylalanine--tRNA ligase subunit alpha;


Pssm-ID: 235239 [Multi-domain]  Cd Length: 489  Bit Score: 38.27  E-value: 3.29e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 968124819  25 STSDIAEYLGKTPPTVTSMVGKLEDRGL--VDREKYKGVELTTEGETVALEVLRHHRLLEA 83
Cdd:PRK04172  22 TLEELAEKLGLPPEAVMRAAEWLEEKGLvkVEERVEEVYVLTEEGKKYAEEGLPERRLLNA 82
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 24-60 3.72e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 37.34  E-value: 3.72e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 968124819   24 VSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREKYKG 60
Cdd:TIGR01884 158 KSVKNIAKKLGKSLSTISRHLAELEKKGLVEQKGRKG 194
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
22-53 4.04e-03

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 34.33  E-value: 4.04e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 968124819   22 PPVSTSDIAEYLGKTPPTVTSMVGKLEDRGLV 53
Cdd:pfam13412  14 PRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
TrmB pfam01978
Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown ...
 8-57 9.66e-03

Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown to be a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter in Thermococcus litoralis.


Pssm-ID: 396525 [Multi-domain]  Cd Length: 67  Bit Score: 33.65  E-value: 9.66e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 968124819    8 DYLKAIYTLQMEQGPpVSTSDIAEYLGKTPPTVTSMVGKLEDRGLVDREK 57
Cdd:pfam01978   8 EYEAKVYLALLKLGP-ATADEIAEESGVPRSKVYEVLRSLEDKGLVEREK 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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