|
Name |
Accession |
Description |
Interval |
E-value |
| NfnB |
COG0778 |
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ... |
3-233 |
2.53e-24 |
|
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation
Pssm-ID: 440541 [Multi-domain] Cd Length: 163 Bit Score: 95.69 E-value: 2.53e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 3 LFEAIRRRRTTNgAFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLVEERPTIDRIAEIsgssmtrtmaagtfferyr 82
Cdd:COG0778 1 LLELLLTRRSVR-KFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLAEA------------------- 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 83 pyfrfsqaemderrdgmlfdklprplrpftkqvftkrgqlmmnalrvpqtLGEENRKLVAGSPLLLGVMLDRHEYRKEEL 162
Cdd:COG0778 61 --------------------------------------------------LAEANQEWVADAPVLIVVCADPDRSEKVPE 90
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 970471537 163 sgFYSVFSMGAAMENVWLATTELGLGiqfvSFPMeTPGAWEEIEGLLRVPPELELMAVYRIGY----LPPERRRP 233
Cdd:COG0778 91 --RYALLDAGIAAQNLLLAARALGLG----TCWI-GGFDPEKVRELLGLPEGEEPVALLALGYpaeeLNPRPRKP 158
|
|
| Nitro_FMN_reductase |
cd02062 |
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ... |
7-225 |
2.96e-24 |
|
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.
Pssm-ID: 380311 [Multi-domain] Cd Length: 139 Bit Score: 94.67 E-value: 2.96e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 7 IRRRRTTNgAFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLVEERPTIDRIAeisgssmtrtmaagtfferyrpyfr 86
Cdd:cd02062 1 IKTRRSIR-KFTDKPVPEEKLRKILEAARLAPSAGNLQPWRFIVVRDREKKEKLA------------------------- 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 87 fsqaemderrdgmlfdklprplrpftkqvftkrgqlmmnalrvpqTLGEENRKLVAGSPLLLGVMLDRHEYRKeelsgfY 166
Cdd:cd02062 55 ---------------------------------------------KLAAPNQKFIAGAPVVIVVVADPDKSRP------W 83
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 970471537 167 SVFSMGAAMENVWLATTELGLGIQFVSFPMEtpgAWEEIEGLLRVPPELELMAVYRIGY 225
Cdd:cd02062 84 ALEDAGAAAQNLLLAAAALGLGSCWIGGFDF---REDKVRELLGIPENLRPVALIAIGY 139
|
|
| Nitroreductase |
pfam00881 |
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ... |
7-225 |
3.32e-24 |
|
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.
Pssm-ID: 425926 [Multi-domain] Cd Length: 168 Bit Score: 95.54 E-value: 3.32e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 7 IRRRRTTNgAFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLVEERPTIDRIAEISGSSMTRTMAAGTFFERYRpyfr 86
Cdd:pfam00881 1 IRQRRSVR-KFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEAALELLLVEPAAALLLLLRR---- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 87 fsQAEMDERRDGMLFDklprplrpftkqvftkrgqlmmnalrvpqtlgeenrklvAGSPLLLGVMLDRHEYRKEELSGFY 166
Cdd:pfam00881 76 --DANLKLLLQDFLRG---------------------------------------APVLIVITASLSTYLRKAAERAYRE 114
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 970471537 167 SVFSMGAAMENVWLATTELGLGIQFVSFPMEtpgawEEIEGLLRVPPELELMAVYRIGY 225
Cdd:pfam00881 115 ALLDAGAAAQNLLLAATSLGLGSCPIGGFDA-----AAVRELLGLPDDERLVGLIAVGY 168
|
|
| BluB |
TIGR02476 |
5,6-dimethylbenzimidazole synthase; A previously published hypothesis that BluB, involved in ... |
3-225 |
2.60e-09 |
|
5,6-dimethylbenzimidazole synthase; A previously published hypothesis that BluB, involved in cobalamin biosynthesis, is EC 1.16.8.1 (cob(II)yrinic acid a,c-diamide reductase) is now contradicted by newer work ascribing a role in 5,6-dimethylbenzimidazole (DMB) biosynthesis. The BluB protein is related to the nitroreductase family (pfam0881). [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]
Pssm-ID: 162875 Cd Length: 205 Bit Score: 55.91 E-value: 2.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 3 LFEAIRRRRTTNgAFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLVEERPTIDRIAEISGSSMTRTmAAGTFFERYR 82
Cdd:TIGR02476 9 VYRLIRERRDVR-HFRSDPVPEAVLERLLDAAHHAPSVGFSQPWRFVRVESPATREAVHALFTRANQAA-AAIYDGERAS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 83 PYFRFsqaemdeRRDGMLfdKLPRPLRPFTKQvfTKRGQLMMNALRVPQTLgeenrklvagsplllgvmldrheyrkeel 162
Cdd:TIGR02476 87 QYHRL-------KLEGIR--EAPVQLAVFCDD--ARGEGHGLGRHTMPEML----------------------------- 126
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 970471537 163 sgfysVFSMGAAMENVWLATTELGLGIQFVSFPMEtpgawEEIEGLLRVPPELELMAVYRIGY 225
Cdd:TIGR02476 127 -----RYSVACAIQNLWLAARAEGLGVGWVSILDP-----DAVRRLLGVPEGWRLVAYLCLGW 179
|
|
| PRK13294 |
PRK13294 |
F420-0--gamma-glutamyl ligase; Provisional |
5-236 |
1.70e-07 |
|
F420-0--gamma-glutamyl ligase; Provisional
Pssm-ID: 183957 [Multi-domain] Cd Length: 448 Bit Score: 51.94 E-value: 1.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 5 EAIRRRRTTNgAFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLVEERPTIDRIAEisgssmtrTMAagtffERYRPy 84
Cdd:PRK13294 255 EAVLLRRSVR-EFSDDPVDPEAVRRAVAAALTAPAPHHTRPVRFVWLRSAAVRTRLLD--------AMR-----DAWRA- 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 85 frfsqaemDERRDGMLFDKLPRPLRpftkqvftkRGQLMMNAlrvPQtlgeenrkLVAgsPLLlgVMLDRHEYRKE---- 160
Cdd:PRK13294 320 --------DLRADGLSEESIARRVR---------RGDILYDA---PE--------LVV--PFL--VPDGAHSYPDArrta 367
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 970471537 161 -ELSGFysVFSMGAAMENVWLATTELGLGIQFVSFPMETPgawEEIEGLLRVPPELELMAVYRIGY-LPPERRRPAID 236
Cdd:PRK13294 368 aERTMF--TVAVGAAVQNLLVALAVEGLGSCWIGSTIFAA---DVVRAVLDLPADWEPLGAVAIGHpAEPPGPRPPRD 440
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NfnB |
COG0778 |
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ... |
3-233 |
2.53e-24 |
|
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation
Pssm-ID: 440541 [Multi-domain] Cd Length: 163 Bit Score: 95.69 E-value: 2.53e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 3 LFEAIRRRRTTNgAFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLVEERPTIDRIAEIsgssmtrtmaagtfferyr 82
Cdd:COG0778 1 LLELLLTRRSVR-KFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLAEA------------------- 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 83 pyfrfsqaemderrdgmlfdklprplrpftkqvftkrgqlmmnalrvpqtLGEENRKLVAGSPLLLGVMLDRHEYRKEEL 162
Cdd:COG0778 61 --------------------------------------------------LAEANQEWVADAPVLIVVCADPDRSEKVPE 90
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 970471537 163 sgFYSVFSMGAAMENVWLATTELGLGiqfvSFPMeTPGAWEEIEGLLRVPPELELMAVYRIGY----LPPERRRP 233
Cdd:COG0778 91 --RYALLDAGIAAQNLLLAARALGLG----TCWI-GGFDPEKVRELLGLPEGEEPVALLALGYpaeeLNPRPRKP 158
|
|
| Nitro_FMN_reductase |
cd02062 |
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ... |
7-225 |
2.96e-24 |
|
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.
Pssm-ID: 380311 [Multi-domain] Cd Length: 139 Bit Score: 94.67 E-value: 2.96e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 7 IRRRRTTNgAFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLVEERPTIDRIAeisgssmtrtmaagtfferyrpyfr 86
Cdd:cd02062 1 IKTRRSIR-KFTDKPVPEEKLRKILEAARLAPSAGNLQPWRFIVVRDREKKEKLA------------------------- 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 87 fsqaemderrdgmlfdklprplrpftkqvftkrgqlmmnalrvpqTLGEENRKLVAGSPLLLGVMLDRHEYRKeelsgfY 166
Cdd:cd02062 55 ---------------------------------------------KLAAPNQKFIAGAPVVIVVVADPDKSRP------W 83
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 970471537 167 SVFSMGAAMENVWLATTELGLGIQFVSFPMEtpgAWEEIEGLLRVPPELELMAVYRIGY 225
Cdd:cd02062 84 ALEDAGAAAQNLLLAAAALGLGSCWIGGFDF---REDKVRELLGIPENLRPVALIAIGY 139
|
|
| Nitroreductase |
pfam00881 |
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ... |
7-225 |
3.32e-24 |
|
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.
Pssm-ID: 425926 [Multi-domain] Cd Length: 168 Bit Score: 95.54 E-value: 3.32e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 7 IRRRRTTNgAFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLVEERPTIDRIAEISGSSMTRTMAAGTFFERYRpyfr 86
Cdd:pfam00881 1 IRQRRSVR-KFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEAALELLLVEPAAALLLLLRR---- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 87 fsQAEMDERRDGMLFDklprplrpftkqvftkrgqlmmnalrvpqtlgeenrklvAGSPLLLGVMLDRHEYRKEELSGFY 166
Cdd:pfam00881 76 --DANLKLLLQDFLRG---------------------------------------APVLIVITASLSTYLRKAAERAYRE 114
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 970471537 167 SVFSMGAAMENVWLATTELGLGIQFVSFPMEtpgawEEIEGLLRVPPELELMAVYRIGY 225
Cdd:pfam00881 115 ALLDAGAAAQNLLLAATSLGLGSCPIGGFDA-----AAVRELLGLPDDERLVGLIAVGY 168
|
|
| nitroreductase |
cd20610 |
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ... |
7-225 |
1.28e-17 |
|
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.
Pssm-ID: 380331 [Multi-domain] Cd Length: 167 Bit Score: 78.09 E-value: 1.28e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 7 IRRRRTTNgAFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLVEERPTIDRIAEISGSsmtrtmaagtfferyrpyfr 86
Cdd:cd20610 1 IKKRRSIR-KFKPDPVPKEDIEKILEAANWAPSGMNRQNWEFVVVKGGEKIEKIGISIKK-------------------- 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 87 fSQAEMDERRDGMLFDKLPRpLRPFTKQvFTKRGqlmmnalrvpqtlgeenrklvaGSPLLLGVMLDRHEYRKEELSGFY 166
Cdd:cd20610 60 -KNEEIARLLEKVFAEKPIR-FRKFRRF-FTLFG----------------------GAPVLVVVYTEPYKPPEERKPDLQ 114
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 167 SVfsmGAAMENVWLATTELGLGiqfvSFPMETPGAWE-EIEGLLRVPPELELMAVYRIGY 225
Cdd:cd20610 115 SV---SAAIQNLLLAAHALGLG----TCWMTGPLYAEdEIEEILEIPDDKELVAVTPLGY 167
|
|
| nitroreductase |
cd20608 |
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ... |
4-225 |
2.12e-17 |
|
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.
Pssm-ID: 380329 [Multi-domain] Cd Length: 145 Bit Score: 76.99 E-value: 2.12e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 4 FEAIRRRRTTNgAFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLVEERPTIDRIAEisgssmtrtmaagtfferYRP 83
Cdd:cd20608 1 FEAIKTRRSVR-RFSDKPVEEEKLEKILEAARLAPSWANKQCWRFIVVTDKETLSELAK------------------KES 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 84 YFRFSQAEmderrdgmlfdklprplrpftkqvftkrgqlmmnalrVPQTLgeenrkLVAGSPLLLGVMLDRHEYRkeels 163
Cdd:cd20608 62 PSNGWLKD-------------------------------------APVII------VVCADPKDSGWLNGQNYYL----- 93
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 970471537 164 gfysvFSMGAAMENVWLATTELGLGIQFVsfpmetpGAWEE--IEGLLRVPPELELMAVYRIGY 225
Cdd:cd20608 94 -----VDAAIAMQNLMLAATDLGLGTCWI-------GAFDEkkVKEILGIPENIRVVALTPLGY 145
|
|
| nitroreductase |
cd02139 |
nitroreductase family protein; A subfamily of the nitroreductase family containing ... |
3-236 |
6.95e-14 |
|
nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.
Pssm-ID: 380316 [Multi-domain] Cd Length: 165 Bit Score: 67.88 E-value: 6.95e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 3 LFEAIRRRRTTNgAFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLVEERPTIDRIAEisgssmtrtmAAGtfferyr 82
Cdd:cd02139 1 VYEAIKKRRSIR-KYKPTPVEEEKLLRILEAARLAPSAKNRQPWRFIVVKDKELKEKLAE----------AAN------- 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 83 pyfrfsqaemderrdgmlfdklprplrpftkqvftkrgqlmmnalrvpqtlgeeNRKLVAGSPLLLGVMLDRHEYRKEEL 162
Cdd:cd02139 63 ------------------------------------------------------GQKFIAEAPVVIVACADPSESGMGCG 88
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 970471537 163 SGFYSVfSMGAAMENVWLATTELGLGIQFVsfpmetpGAWEE--IEGLLRVPPELELMAVYRIGY---LPPERRRPAID 236
Cdd:cd02139 89 KPYYLV-DVAIAMEHLVLAATEEGLGTCWI-------GAFDEdkVKEILGIPEEYRVVALTPLGYpaeEPPPRPRKPLE 159
|
|
| nitroreductase |
cd02150 |
nitroreductase family protein; A subfamily of the nitroreductase family containing ... |
7-236 |
1.35e-12 |
|
nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.
Pssm-ID: 380325 [Multi-domain] Cd Length: 156 Bit Score: 64.16 E-value: 1.35e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 7 IRRRRTTNgAFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLVEERPTIDRIAEISgssmtrtmaagtfferyrPYFR 86
Cdd:cd02150 1 ILTRRSIR-KYTDKPVEEEDIEKLLRAAMAAPSAGNQQPWHFIVVTDREKLDKIAEAH------------------PYGK 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 87 fsqaemderrdgMLFDklprplrpftkqvftkrgqlmmNALRVpqtlgeenrkLVAGSPlllgvmldrheyRKEELSGfY 166
Cdd:cd02150 62 ------------MLKE----------------------APLAI----------VVCGDP------------SKEKAPG-Y 84
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 970471537 167 SVFSMGAAMENVWLATTELGLGIQFVS-FPMEtpGAWEEIEGLLRVPPELELMAVYRIGYlpPERRRPAID 236
Cdd:cd02150 85 WVQDCSAATENILLAAHALGLGAVWLGvYPFE--ERVKAIREILNIPENIIPFCVIALGY--PAEEKEPKD 151
|
|
| nitroreductase |
cd02151 |
nitroreductase family protein; A subfamily of the nitroreductase family containing ... |
5-237 |
1.46e-12 |
|
nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers..
Pssm-ID: 380326 [Multi-domain] Cd Length: 157 Bit Score: 64.09 E-value: 1.46e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 5 EAIRRRRTTNgAFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLVEERPTIDRIAEIsgssmtRTMAAgtfferyrpy 84
Cdd:cd02151 1 ELLKKRRSIR-KYTDEPIEEEKLEEILEAALLAPSSRNSRPVEFIVVDDKETLKKLSEC------KPHGS---------- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 85 frfsqaemderrdgmlfdklprplrpftkqvftkrgqlmmnalrvpqtlgeenrKLVAGSPLLLGVMLDrheyrkEELSG 164
Cdd:cd02151 64 ------------------------------------------------------AFLKGAPAAIVVLAD------TEKSD 83
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 165 FY----SVfsmgaAMENVWLATTELGLG---IQFVSFPMETPG-AWEEIEGLLRVPPELELMAVYRIGYlpPERRRPAID 236
Cdd:cd02151 84 TWiedaSI-----AATYIQLAAESLGLGscwIQIRNRETQDGKtAEEYVRELLGIPENYRVLCIIALGY--PDEEKPPHE 156
|
.
gi 970471537 237 W 237
Cdd:cd02151 157 D 157
|
|
| BluB |
cd02145 |
5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5, ... |
4-245 |
8.97e-12 |
|
5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5,6-dimethylbenzimidazole (DMB), a component of vitamin B12; is is a subfamily of the nitroreductase family; nitroreductases typically reduce their substrates by using NAD(P)H as electron donor and often use FMN as a cofactor.
Pssm-ID: 380321 Cd Length: 196 Bit Score: 62.76 E-value: 8.97e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 4 FEAIRRRRTTNGaFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLVEERPTIDRIAEIsgssmtrtmaagtfFERYRP 83
Cdd:cd02145 1 YRVIRWRRDVRH-FRPDPVPEEVLERLLQAAHLAPSVGLMQPWRFVRVRSAATRKAVHEL--------------FQRANA 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 84 yfrfSQAEMDERRDGMLFDKLprplrpftkqvftkrgqlmmnalrvpqtlgeenrKLVA--GSPLLLGVMLDRHEYRKEE 161
Cdd:cd02145 66 ----EAAEMYTGERAAQYRTL----------------------------------KLEGieEAPLQLAVFCDRARAGGHG 107
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 162 LSGFYS----VFSMGAAMENVWLATTELGLGIQFVSFPMEtpgawEEIEGLLRVPPELELMAVYRIGYLPPERRRPAIDW 237
Cdd:cd02145 108 LGRTTMpemdLYSSVCAVQNLWLAARAEGLGVGWVSILDP-----DEVKRLLGIPEHWEPVAYLCIGYPEFFYDEPELEQ 182
|
....*...
gi 970471537 238 TSSERKRP 245
Cdd:cd02145 183 AGWEQRRP 190
|
|
| PnbA_NfnB-like |
cd02136 |
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ... |
6-238 |
2.51e-11 |
|
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.
Pssm-ID: 380313 [Multi-domain] Cd Length: 152 Bit Score: 60.29 E-value: 2.51e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 6 AIRRRRTTNgAFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLVEErPTIDRIAEIsgssmtrtmaagtFFeryrpyf 85
Cdd:cd02136 1 AIKSRRSVR-AFKDKPVPKETIEKILEAARRAPSGKNTQPWRVYVVTG-KARERLKKA-------------FF------- 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 86 rfsqaemderrdgmlfdklprplrpftkqvftkrgqlmmnalrvpqtlgeenrklvaGSPLLLGVMLDRheyrkeeLSGF 165
Cdd:cd02136 59 ---------------------------------------------------------GAPVALFLTMDK-------VLGP 74
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 166 YSVFSMGAAMENVWLATTELGLG--IQfVSFPMETpgawEEIEGLLRVPPELELMAVYRIGY--------LPPERRRPAI 235
Cdd:cd02136 75 WSWFDLGAFLQNLMLAAHALGLGtcPQ-GALAGYP----DVVRKELGIPDDEELVCGIALGYpdpdapvnQFRTPREPLE 149
|
...
gi 970471537 236 DWT 238
Cdd:cd02136 150 EFV 152
|
|
| YdjA-like |
cd02135 |
nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the ... |
4-188 |
8.87e-11 |
|
nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.
Pssm-ID: 380312 [Multi-domain] Cd Length: 162 Bit Score: 59.15 E-value: 8.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 4 FEAIRRRRTTNGAFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLVEERptidriaeisgssmtrtmAAGTFFERYRP 83
Cdd:cd02135 1 LELIKTRRSIRKFKLTGAPPEEQLEELLEAAMWAPNHGKLEPWRFIVVTGE------------------GRERLAELLAA 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 84 YFRFSQAEMDERRdgmlfdklprplrpftkqvftkrgqlmmnalrvpqtlGEENRKLVAGSPLLLGVMLDRHEYRK---- 159
Cdd:cd02135 63 AAAARAPGADPEK-------------------------------------LEKAREKALRAPVVIAVVAKPDEDPKvpew 105
|
170 180
....*....|....*....|....*....
gi 970471537 160 EELsgfysvFSMGAAMENVWLATTELGLG 188
Cdd:cd02135 106 EQY------AAVGAAVQNLLLAAHALGLG 128
|
|
| nitroreductase |
cd03370 |
uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus ... |
5-64 |
9.13e-11 |
|
uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus thermophilus NADH oxidase and other, uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.
Pssm-ID: 380327 [Multi-domain] Cd Length: 191 Bit Score: 59.64 E-value: 9.13e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 5 EAIRRRRTTNgAFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLVEERPTIDRIAEIS 64
Cdd:cd03370 3 EAIESRRSIR-KYTQEPVPDEDLREILRLAGLAPSAWNIQPWRFVVVRDAELKEQLQAAA 61
|
|
| BluB |
TIGR02476 |
5,6-dimethylbenzimidazole synthase; A previously published hypothesis that BluB, involved in ... |
3-225 |
2.60e-09 |
|
5,6-dimethylbenzimidazole synthase; A previously published hypothesis that BluB, involved in cobalamin biosynthesis, is EC 1.16.8.1 (cob(II)yrinic acid a,c-diamide reductase) is now contradicted by newer work ascribing a role in 5,6-dimethylbenzimidazole (DMB) biosynthesis. The BluB protein is related to the nitroreductase family (pfam0881). [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]
Pssm-ID: 162875 Cd Length: 205 Bit Score: 55.91 E-value: 2.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 3 LFEAIRRRRTTNgAFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLVEERPTIDRIAEISGSSMTRTmAAGTFFERYR 82
Cdd:TIGR02476 9 VYRLIRERRDVR-HFRSDPVPEAVLERLLDAAHHAPSVGFSQPWRFVRVESPATREAVHALFTRANQAA-AAIYDGERAS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 83 PYFRFsqaemdeRRDGMLfdKLPRPLRPFTKQvfTKRGQLMMNALRVPQTLgeenrklvagsplllgvmldrheyrkeel 162
Cdd:TIGR02476 87 QYHRL-------KLEGIR--EAPVQLAVFCDD--ARGEGHGLGRHTMPEML----------------------------- 126
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 970471537 163 sgfysVFSMGAAMENVWLATTELGLGIQFVSFPMEtpgawEEIEGLLRVPPELELMAVYRIGY 225
Cdd:TIGR02476 127 -----RYSVACAIQNLWLAARAEGLGVGWVSILDP-----DAVRRLLGVPEGWRLVAYLCLGW 179
|
|
| MhqN-like |
cd02137 |
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ... |
4-53 |
7.74e-08 |
|
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.
Pssm-ID: 380314 [Multi-domain] Cd Length: 147 Bit Score: 50.32 E-value: 7.74e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 970471537 4 FEAIRRRRTTNGaFLPD-PVSEEHQRLLMELAGRAPSQLNSQPWRFVLVEE 53
Cdd:cd02137 1 LEVIKSRRSVRN-FDPDhKIPKEELKEILELATLAPSSFNLQPWRFVVVRD 50
|
|
| nitroreductase |
cd20609 |
nitroreductase family protein; A subfamily of the nitroreductase family containing ... |
2-63 |
1.51e-07 |
|
nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.
Pssm-ID: 380330 [Multi-domain] Cd Length: 145 Bit Score: 49.69 E-value: 1.51e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 970471537 2 ELFEAIRRRRTTNgAFLPDPVSEEHQRLLMElAGR-APSQLNSQPWRFVLVEERPTIDRIAEI 63
Cdd:cd20609 1 DFLELAKKRYSVR-KFSDKPVEKEKLDKILE-AGRlAPTAVNYQPQRILVVRSEEALEKLAKA 61
|
|
| PRK13294 |
PRK13294 |
F420-0--gamma-glutamyl ligase; Provisional |
5-236 |
1.70e-07 |
|
F420-0--gamma-glutamyl ligase; Provisional
Pssm-ID: 183957 [Multi-domain] Cd Length: 448 Bit Score: 51.94 E-value: 1.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 5 EAIRRRRTTNgAFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLVEERPTIDRIAEisgssmtrTMAagtffERYRPy 84
Cdd:PRK13294 255 EAVLLRRSVR-EFSDDPVDPEAVRRAVAAALTAPAPHHTRPVRFVWLRSAAVRTRLLD--------AMR-----DAWRA- 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 85 frfsqaemDERRDGMLFDKLPRPLRpftkqvftkRGQLMMNAlrvPQtlgeenrkLVAgsPLLlgVMLDRHEYRKE---- 160
Cdd:PRK13294 320 --------DLRADGLSEESIARRVR---------RGDILYDA---PE--------LVV--PFL--VPDGAHSYPDArrta 367
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 970471537 161 -ELSGFysVFSMGAAMENVWLATTELGLGIQFVSFPMETPgawEEIEGLLRVPPELELMAVYRIGY-LPPERRRPAID 236
Cdd:PRK13294 368 aERTMF--TVAVGAAVQNLLVALAVEGLGSCWIGSTIFAA---DVVRAVLDLPADWEPLGAVAIGHpAEPPGPRPPRD 440
|
|
| iodotyrosine_dehalogenase |
cd02144 |
iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the ... |
3-63 |
1.80e-07 |
|
iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers.
Pssm-ID: 380320 Cd Length: 192 Bit Score: 50.23 E-value: 1.80e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 970471537 3 LFEAIRRRRTTNgAFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLVEERPTIDRIAEI 63
Cdd:cd02144 1 FYELMKKRRSVR-DFSSEPVPREVIENAIRTAGTAPSGANTQPWTFVVVSDPEIKRKIREA 60
|
|
| TdsD-like |
cd02138 |
nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase ... |
16-62 |
1.76e-06 |
|
nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.
Pssm-ID: 380315 [Multi-domain] Cd Length: 174 Bit Score: 47.15 E-value: 1.76e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 970471537 16 AFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLV-EERPTIDRIAE 62
Cdd:cd02138 10 AFSPEPISEEDLLSLFEAARWAPSCFNEQPWRFVVArRDTEAFEKLLD 57
|
|
| PRK05365 |
PRK05365 |
malonic semialdehyde reductase; Provisional |
3-74 |
1.75e-05 |
|
malonic semialdehyde reductase; Provisional
Pssm-ID: 180040 [Multi-domain] Cd Length: 195 Bit Score: 44.42 E-value: 1.75e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 970471537 3 LFeaiRRRRTTNGaFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLV---EERptiDRIAE-ISGSSMTRTMAA 74
Cdd:PRK05365 12 LF---TEARTHNG-WLDEPVSDEQLRELYDLVKWGPTSANCSPARFVFVrsaEAK---ERLRPaLSEGNLAKTLAA 80
|
|
| nitroreductase_FeS-like |
cd02143 |
nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family ... |
7-63 |
2.96e-05 |
|
nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family utilize FMN as a cofactor. This family may be involved in the reduction of flavin or nitroaromatic compounds via an obligatory two-electron transfer. Nitroreductase is homodimer. Each subunit contains one FMN molecule.
Pssm-ID: 380319 [Multi-domain] Cd Length: 187 Bit Score: 43.62 E-value: 2.96e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 970471537 7 IRRRRTTNgAFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLVEERPTIDRIAEI 63
Cdd:cd02143 2 LRSRRSIR-RYKDKPVPRETLEKLLDIARYAPTGHNSQPVHWLVVDDPEKVRRLAEL 57
|
|
| PRK07877 |
PRK07877 |
Rv1355c family protein; |
2-193 |
8.03e-05 |
|
Rv1355c family protein;
Pssm-ID: 236122 [Multi-domain] Cd Length: 722 Bit Score: 43.83 E-value: 8.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 2 ELFEAIRRRRTTNGAFLPDPVSEEHQRLLMELAGRAPSQLNsqpwrfvLVEERPTIDRIAEISGSS-----MTRTMAAGT 76
Cdd:PRK07877 475 ALYQPMLLRETNRHHGTPAPIDDATVEALTAAAAAEGARLH-------LLTDRDDIDAAAEILAAAdriryLTPRLHEEM 547
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970471537 77 FFERYRPYFRFSQAEMDERR------DGMLFDKLPRPlrpftkQVFTKRGQLmmNALRVpqtLGEENRKLVAGSPLLLGV 150
Cdd:PRK07877 548 ISELRWPGDDAPDTGIDVRTleldpaDLAGLDILRRP------DVMARLARW--DGGSA---LGDDTRDRVSSSSALAVV 616
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 970471537 151 MLDRHEYRkeelsgfySVFSMGAAMENVWLATTELGLGIQFVS 193
Cdd:PRK07877 617 TVPGATLT--------DYARGGSAMEAVWIAAQQLGLAVQPVS 651
|
|
| PRK11053 |
PRK11053 |
oxygen-insensitive NAD(P)H nitroreductase; |
1-50 |
2.88e-04 |
|
oxygen-insensitive NAD(P)H nitroreductase;
Pssm-ID: 182929 [Multi-domain] Cd Length: 217 Bit Score: 41.11 E-value: 2.88e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 970471537 1 MELFEAIRRRRTTNgAFlpDP---VSEEHQRLLMELAGRAPSQLNSQPWRFVL 50
Cdd:PRK11053 1 MDIVSVAKKRYTTK-AF--DPskkLPAEQIEQIKTLLRFSPSSVNSQPWHFIV 50
|
|
| RutE-like |
cd02148 |
nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family ... |
11-74 |
1.89e-03 |
|
nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. RutE is involved in the utilization of uracil as the sole nitrogen source; it appears to have the same function as YdfG, which reduces malonic semialdehyde to 3-hydroxypropionic acid.
Pssm-ID: 380323 [Multi-domain] Cd Length: 186 Bit Score: 38.39 E-value: 1.89e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 970471537 11 RTTNgAFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLVEERPTIDRIAE-ISGSSMTRTMAA 74
Cdd:cd02148 10 RTHN-AWEDKPVSDEELRAIYDLAKWGPTAANCSPARIVFVRSAEAKERLVPhLSEGNREKTMAA 73
|
|
| TM1586_NiRdase |
pfam14512 |
Putative TM nitroreductase; Compared with the more traditional NADH oxidase/flavin reductase ... |
30-53 |
3.32e-03 |
|
Putative TM nitroreductase; Compared with the more traditional NADH oxidase/flavin reductase family, this family is a duplication, consisting of two similar domains arranged as the subunits of the dimeric NADH oxidase/flavin reductase with one conserved active site.
Pssm-ID: 405236 [Multi-domain] Cd Length: 214 Bit Score: 38.04 E-value: 3.32e-03
|
| NfsB-like |
cd02149 |
nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This ... |
5-52 |
6.56e-03 |
|
nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family includes FRase I in Vibrio fischeri, wihich reduces FMN into FMNH2 as part of the bioluminescent reaction. The family also includes oxygen-insensitive nitroreductases that use NADH or NADPH as an electron donor in the ping pong bi bi mechanism. This type of nitroreductase can be used in cancer chemotherapy to activate a range of prodrugs.
Pssm-ID: 380324 [Multi-domain] Cd Length: 156 Bit Score: 36.46 E-value: 6.56e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 970471537 5 EAIRRRRTTNgAFLPD-PVSEEHQRLLMELAGRAPSQLNSQPWRFVLVE 52
Cdd:cd02149 4 ELLNFRYATK-KFDPNkKISDEDLETILEALRLSPSSFGLEPWKFLVVE 51
|
|
| NfsA-like |
cd02146 |
nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin ... |
16-65 |
7.40e-03 |
|
nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.
Pssm-ID: 380322 [Multi-domain] Cd Length: 229 Bit Score: 36.83 E-value: 7.40e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 970471537 16 AFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVLVEERPTIDRIAEISG 65
Cdd:cd02146 13 KFTDEPLTDETLETLIAAAQSASTSSNLQAYSVIVVTDPELREKLAELAG 62
|
|
| |
