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Conserved domains on  [gi|972365929|ref|WP_059020414|]
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MULTISPECIES: response regulator [Vibrio]

Protein Classification

response regulator( domain architecture ID 11468273)

two-component system response regulator such as transcriptional regulatory proteins CitB from Klebsiella pneumoniae and and CitT from Bacillus subtilis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
dpiA super family cl32452
two-component response regulator DpiA; Provisional
 1-227 6.24e-56

two-component response regulator DpiA; Provisional


The actual alignment was detected with superfamily member PRK10046:

Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 177.90  E-value: 6.24e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   1 MNAITRVMVIEDDIAIAELHHRYLEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCD 80
Cdd:PRK10046   1 MTAPLTLLIVEDETPLAEMHAEYIRHIPGFSQILLAGNLAQARMMIERFKPGLILLDNYLPDGRGINLLHELVQAHYPGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929  81 VILITAARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALKKYQSQQQEFESVSDLNQGLVDKMLQANAKADSGkvSTLPKG 160
Cdd:PRK10046  81 VVFTTAASDMETVSEAVRCGVFDYLIKPIAYERLGQTLTRFRQRKHMLESIDSASQKQIDEMFNAYARGEPK--DELPTG 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 972365929 161 IDGVTLDKIRAIFQQAdAVNITADEAGERIGASRTTARRYLEFLITTGELIADLNYGTVGRPERCYN 227
Cdd:PRK10046 159 IDPLTLNAVRKLFKEP-GVQHTAETVAQALTISRTTARRYLEYCASRHLIIAEIVHGKVGRPQRIYH 224
 
Name Accession Description Interval E-value
dpiA PRK10046
two-component response regulator DpiA; Provisional
 1-227 6.24e-56

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 177.90  E-value: 6.24e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   1 MNAITRVMVIEDDIAIAELHHRYLEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCD 80
Cdd:PRK10046   1 MTAPLTLLIVEDETPLAEMHAEYIRHIPGFSQILLAGNLAQARMMIERFKPGLILLDNYLPDGRGINLLHELVQAHYPGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929  81 VILITAARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALKKYQSQQQEFESVSDLNQGLVDKMLQANAKADSGkvSTLPKG 160
Cdd:PRK10046  81 VVFTTAASDMETVSEAVRCGVFDYLIKPIAYERLGQTLTRFRQRKHMLESIDSASQKQIDEMFNAYARGEPK--DELPTG 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 972365929 161 IDGVTLDKIRAIFQQAdAVNITADEAGERIGASRTTARRYLEFLITTGELIADLNYGTVGRPERCYN 227
Cdd:PRK10046 159 IDPLTLNAVRKLFKEP-GVQHTAETVAQALTISRTTARRYLEYCASRHLIIAEIVHGKVGRPQRIYH 224
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 6-130 6.59e-50

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 159.36  E-value: 6.59e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILIT 85
Cdd:COG4565    5 RVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDVIVIT 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 972365929  86 AARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALKKYQSQQQEFES 130
Cdd:COG4565   85 AARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRRLLRE 129
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 5-121 1.01e-45

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 148.16  E-value: 1.01e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   5 TRVMVIEDDIAIAELHHRYLEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILI 84
Cdd:cd19925    1 INVLIVEDDPMVAEIHRAYVEQVPGFTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVV 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 972365929  85 TAARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALKKY 121
Cdd:cd19925   81 TAANDVETVREALRLGVVDYLIKPFTFERLRQRLERY 117
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 7-119 5.10e-21

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 84.51  E-value: 5.10e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929    7 VMVIEDDIAIAELHHRYLEQMGgfDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITA 86
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEG--YVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTA 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 972365929   87 ARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALK 119
Cdd:pfam00072  79 HGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 6-61 6.97e-09

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 50.64  E-value: 6.97e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 972365929     6 RVMVIEDDIAIAELHHRYLEQMGGfdVVGIATTQSEALMQLDILKPDLVLLDVYLP 61
Cdd:smart00448   2 RILVVDDDPLLRELLKALLEKEGY--EVDEATDGEEALELLKEEKPDLILLDIMMP 55
 
Name Accession Description Interval E-value
dpiA PRK10046
two-component response regulator DpiA; Provisional
 1-227 6.24e-56

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 177.90  E-value: 6.24e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   1 MNAITRVMVIEDDIAIAELHHRYLEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCD 80
Cdd:PRK10046   1 MTAPLTLLIVEDETPLAEMHAEYIRHIPGFSQILLAGNLAQARMMIERFKPGLILLDNYLPDGRGINLLHELVQAHYPGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929  81 VILITAARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALKKYQSQQQEFESVSDLNQGLVDKMLQANAKADSGkvSTLPKG 160
Cdd:PRK10046  81 VVFTTAASDMETVSEAVRCGVFDYLIKPIAYERLGQTLTRFRQRKHMLESIDSASQKQIDEMFNAYARGEPK--DELPTG 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 972365929 161 IDGVTLDKIRAIFQQAdAVNITADEAGERIGASRTTARRYLEFLITTGELIADLNYGTVGRPERCYN 227
Cdd:PRK10046 159 IDPLTLNAVRKLFKEP-GVQHTAETVAQALTISRTTARRYLEYCASRHLIIAEIVHGKVGRPQRIYH 224
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 6-130 6.59e-50

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 159.36  E-value: 6.59e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILIT 85
Cdd:COG4565    5 RVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDVIVIT 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 972365929  86 AARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALKKYQSQQQEFES 130
Cdd:COG4565   85 AARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRRLLRE 129
PRK10430 PRK10430
two-component system response regulator DcuR;
7-222 4.76e-47

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 155.65  E-value: 4.76e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQMGGFDVVGIATT--QSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILI 84
Cdd:PRK10430   4 VLIVDDDAMVAELNRRYVAQIPGFQCCGTASTleQAKEIIFNSDTPIDLILLDIYMQQENGLDLLPVLHEAGCKSDVIVI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929  85 TAARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALKKYQSQQQEFESVSDLNQGLVDKML--QANAKADSGKvstLPKGID 162
Cdd:PRK10430  84 SSAADAATIKDSLHYGVVDYLIKPFQASRFEEALTGWRQKKMALEKHQYYDQAELDQLIhgSSSNEQDPRR---LPKGLT 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 972365929 163 GVTLdkiRAIFQQADA---VNITADEAGERIGASRTTARRYLEFLITTGELIADLNYGTVGRP 222
Cdd:PRK10430 161 PQTL---RTLCQWIDAhqdYEFSTDELANAVNISRVSCRKYLIWLVNCHILFTSIHYGVTGRP 220
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 5-121 1.01e-45

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 148.16  E-value: 1.01e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   5 TRVMVIEDDIAIAELHHRYLEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILI 84
Cdd:cd19925    1 INVLIVEDDPMVAEIHRAYVEQVPGFTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVV 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 972365929  85 TAARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALKKY 121
Cdd:cd19925   81 TAANDVETVREALRLGVVDYLIKPFTFERLRQRLERY 117
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 6-136 3.77e-26

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 101.05  E-value: 3.77e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILIT 85
Cdd:COG3279    3 KILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIFTT 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 972365929  86 AARDVdtLQQAMRGGVVDYLLKPVMFPRLEAALKKYQSQQQEFESVSDLNQ 136
Cdd:COG3279   83 AYDEY--ALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPE 131
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 6-139 1.94e-25

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 98.49  E-value: 1.94e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGgFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILIT 85
Cdd:COG0745    3 RILVVEDDPDIRELLADALEREG-YEVD-TAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLT 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 972365929  86 AARDVDTLQQAMRGGVVDYLLKPVMFP----RLEAALKKYQSQQQEFESVSDLNQGLV 139
Cdd:COG0745   81 ARDDEEDRVRGLEAGADDYLTKPFDPEellaRIRALLRRRAAEVLRVGDLLDLAAREV 138
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 6-127 3.59e-25

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 101.96  E-value: 3.59e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGgFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILIT 85
Cdd:COG2204    4 RILVVDDDPDIRRLLKELLERAG-YEVE-TAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVILLT 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 972365929  86 AARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALKKYQSQQQE 127
Cdd:COG2204   82 GYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALERRRL 123
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 8-108 3.11e-23

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 89.59  E-value: 3.11e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   8 MVIEDDIAIAELHHRYLEQmGGFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITAA 87
Cdd:cd00156    1 LIVDDDPAIRELLKSLLER-EGYEVD-TAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAK 78

                         90       100
                 ....*....|....*....|.
gi 972365929  88 RDVDTLQQAMRGGVVDYLLKP 108
Cdd:cd00156   79 ADEEDAVRALELGADDYLVKP 99
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 7-125 6.83e-23

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 89.56  E-value: 6.83e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQmGGFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITA 86
Cdd:cd17572    1 VLLVEDSPSLAALYQEYLSD-EGYKVT-HVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVITA 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 972365929  87 ARDVDTLQQAMRGGVVDYLLKPVMFPRLEA----ALKKYQSQQ 125
Cdd:cd17572   79 HGSVDIAVEAMRLGAYDFLEKPFDADRLRVtvrnALKHRKLTK 121
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 6-108 1.17e-22

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 88.29  E-value: 1.17e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILIT 85
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILEWEAGFEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIILS 80

                         90       100
                 ....*....|....*....|...
gi 972365929  86 AARDVDTLQQAMRGGVVDYLLKP 108
Cdd:COG4753   81 GYSDFEYAQEAIKLGADDYLLKP 103
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 7-120 6.95e-22

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 87.01  E-value: 6.95e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQMG-GFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILIT 85
Cdd:cd17536    1 VLIVDDEPLIREGLKKLIDWEElGFEVVGEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIILS 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 972365929  86 AARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALKK 120
Cdd:cd17536   81 GYDDFEYAQKAIRLGVVDYLLKPVDEEELEEALEK 115
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 6-118 3.33e-21

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 86.89  E-value: 3.33e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGgFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCD--VIL 83
Cdd:COG3706    3 RILVVDDDPTNRKLLRRLLEAAG-YEVV-EAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRADPRTADipIIF 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 972365929  84 ITAARDVDTLQQAMRGGVVDYLLKPVMFPRLEAAL 118
Cdd:COG3706   81 LTALDDEEDRARALEAGADDYLTKPFDPEELLARV 115
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 6-127 4.46e-21

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 84.90  E-value: 4.46e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGgFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCD--VIL 83
Cdd:COG0784    7 RILVVDDNPDNRELLRRLLERLG-YEVT-TAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIRALPRLPDipIIA 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 972365929  84 ITAARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALKKYQSQQQE 127
Cdd:COG0784   85 LTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRLLARASA 128
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 7-119 5.10e-21

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 84.51  E-value: 5.10e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929    7 VMVIEDDIAIAELHHRYLEQMGgfDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITA 86
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEG--YVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTA 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 972365929   87 ARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALK 119
Cdd:pfam00072  79 HGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 6-127 1.69e-19

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 82.27  E-value: 1.69e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGgFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILIT 85
Cdd:COG4567    6 SLLLVDDDEAFARVLARALERRG-FEVT-TAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVVLT 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 972365929  86 AARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALKKYQSQQQE 127
Cdd:COG4567   84 GYASIATAVEAIKLGADDYLAKPADADDLLAALERAEGDAPA 125
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 6-194 2.22e-19

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 83.29  E-value: 2.22e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGgFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCD--VIL 83
Cdd:COG3437    8 TVLIVDDDPENLELLRQLLRTLG-YDVV-TAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLRADPSTRDipVIF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929  84 ITAARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALKKYQSQQQEFESVSDLNQGLvdkmLQANAKADSGKVstlpkGIDG 163
Cdd:COG3437   86 LTALADPEDRERALEAGADDYLTKPFDPEELLARVRNALELRRLQRELDDLVLYL----KLAAPLHDIGKI-----GIPD 156

                        170       180       190
                 ....*....|....*....|....*....|.
gi 972365929 164 VTLDKIRAIFQQADAVNITADEAGERIGASR 194
Cdd:COG3437  157 AILLKPGKLTPEEWEITHAHIGAEILSGSLL 187
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 8-108 1.75e-17

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 74.75  E-value: 1.75e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   8 MVIEDDIAIAELHHRYLEQMGgFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITAA 87
Cdd:cd17574    1 LVVEDDEEIAELLSDYLEKEG-YEVD-TAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTAK 78

                         90       100
                 ....*....|....*....|.
gi 972365929  88 RDVDTLQQAMRGGVVDYLLKP 108
Cdd:cd17574   79 DEEEDKVLGLELGADDYITKP 99
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 6-119 6.02e-17

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 73.98  E-value: 6.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGgFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGC-GLDILNHVRgSNQGCDVILI 84
Cdd:cd17534    2 KILIVEDEAIIALDLKEILESLG-YEVVGIADSGEEAIELAEENKPDLILMDINLKGDMdGIEAAREIR-EKFDIPVIFL 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 972365929  85 TAARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALK 119
Cdd:cd17534   80 TAYSDEETLERAKETNPYGYLVKPFNERELKAAIE 114
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 6-126 1.69e-16

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 74.61  E-value: 1.69e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGgFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQgCDVILIT 85
Cdd:COG3707    5 RVLVVDDEPLRRADLREGLREAG-YEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERP-APVILLT 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 972365929  86 AARDVDTLQQAMRGGVVDYLLKPV----MFPRLEAALKKYQSQQQ 126
Cdd:COG3707   83 AYSDPELIERALEAGVSAYLVKPLdpedLLPALELALARFRELRA 127
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 7-107 6.11e-16

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 71.00  E-value: 6.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITA 86
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLTA 80

                         90       100
                 ....*....|....*....|.
gi 972365929  87 ARDVDTLQQAMRGGVVDYLLK 107
Cdd:cd17535   81 HDDPEYVLRALKAGAAGYLLK 101
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 7-119 1.74e-14

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 67.12  E-value: 1.74e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQMGgfDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITA 86
Cdd:cd17624    1 ILLVEDDALLGDGLKTGLRKAG--YAVDWVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLILTA 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 972365929  87 ARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALK 119
Cdd:cd17624   79 RDGVDDRVAGLDAGADDYLVKPFALEELLARLR 111
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 5-120 3.42e-14

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 66.53  E-value: 3.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   5 TRVMVIEDDIAIAELHHRYLEQmGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILI 84
Cdd:cd17542    1 KKVLIVDDAAFMRMMLKDILTK-AGYEVVGEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIMC 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 972365929  85 TAARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALKK 120
Cdd:cd17542   80 SAMGQEEMVKEAIKAGAKDFIVKPFQPERVLEAVEK 115
REC_PhyR cd17540
phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is ...
 5-86 3.02e-13

phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is a hybrid stress regulator that contains an N-terminal sigma-like (SL) domain and a C-terminal REC domain. Phosphorylation of the REC domain is known to promote binding of the SL domain to an anti-sigma factor. PhyR thus functions as an anti-anti-sigma factor in its phosphorylated state. It is involved in the general stress response. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381095 [Multi-domain]  Cd Length: 117  Bit Score: 64.19  E-value: 3.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   5 TRVMVIEDDIAIAeLHHRYLEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGC-GLDILNHVRGSNQgCDVIL 83
Cdd:cd17540    1 TRVLIIEDEPLIA-MDLEQIVEDLGHQVVGIARTRDEAVALARRERPDLILADIQLADGSsGIDAVNEILTTHD-VPVIF 78


                 ...
gi 972365929  84 ITA 86
Cdd:cd17540   79 VTA 81
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 7-124 8.56e-13

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 62.94  E-value: 8.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDD-IAIAELHHrYLEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILIT 85
Cdd:cd17532    1 ALIVDDEpLAREELRY-LLEEHPDIEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLSKLAKPPLIVFVT 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 972365929  86 AARD--VdtlqQAMRGGVVDYLLKPVMFPRLEAALKKYQSQ 124
Cdd:cd17532   80 AYDEyaV----EAFELNAVDYLLKPFSEERLAEALAKLRKR 116
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 5-108 1.14e-12

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 62.65  E-value: 1.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   5 TRVMVIEDDIAIAELHHRYLEQmGGFDVVGIATTQSeALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCD--VI 82
Cdd:cd17618    1 RTILIVEDEPAIREMIAFNLER-AGFDVVEAEDAES-AVNLIVEPRPDLILLDWMLPGGSGIQFIRRLKRDEMTRDipII 78

                         90       100
                 ....*....|....*....|....*.
gi 972365929  83 LITAARDVDTLQQAMRGGVVDYLLKP 108
Cdd:cd17618   79 MLTARGEEEDKVRGLEAGADDYITKP 104
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 6-119 1.22e-12

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 62.37  E-value: 1.22e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLeQMGGFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILIT 85
Cdd:cd17615    1 RVLVVDDEPNITELLSMAL-RYEGWDVE-TAADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVLFLT 78

                         90       100       110
                 ....*....|....*....|....*....|....
gi 972365929  86 AARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALK 119
Cdd:cd17615   79 AKDSVEDRIAGLTAGGDDYVTKPFSLEEVVARLR 112
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 6-109 1.44e-12

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 62.07  E-value: 1.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGGFDVVGIaTTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDV--IL 83
Cdd:cd17551    2 RILIVDDNPTNLLLLEALLRSAGYLEVVSF-TDPREALAWCRENPPDLILLDYMMPGMDGLEFIRRLRALPGLEDVpiVM 80

                         90       100
                 ....*....|....*....|....*.
gi 972365929  84 ITAARDVDTLQQAMRGGVVDYLLKPV 109
Cdd:cd17551   81 ITADTDREVRLRALEAGATDFLTKPF 106
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
7-141 2.30e-12

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 65.44  E-value: 2.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQMGGfdVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITA 86
Cdd:PRK10365   8 ILVVDDDISHCTILQALLRGWGY--NVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIMTA 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 972365929  87 ARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALKKYQSQQQ----EFESVSDLNQGLVDK 141
Cdd:PRK10365  86 YSSVETAVEALKTGALDYLIKPLDFDNLQATLEKALAHTHsidaETPAVTASQFGMVGK 144
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 7-138 3.36e-12

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 61.35  E-value: 3.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEqMGGFDVVGiATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITA 86
Cdd:cd17549    1 VLLVDDDADVREALQQTLE-LAGFRVRA-FADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELDPDLPVILITG 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 972365929  87 ARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALKKYQSQQQEFESVSDLNQGL 138
Cdd:cd17549   79 HGDVPMAVEAMRAGAYDFLEKPFDPERLLDVVRRALEKRRLVLENRRLRQQL 130
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 7-138 3.46e-12

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 62.81  E-value: 3.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQMGgFDVVGIATTQsEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITA 86
Cdd:COG4566    2 VYIVDDDEAVRDSLAFLLESAG-LRVETFASAE-AFLAALDPDRPGCLLLDVRMPGMSGLELQEELAARGSPLPVIFLTG 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 972365929  87 ARDVDTLQQAMRGGVVDYLLKPV----MFPRLEAALKKYQSQQQEFESVSDLNQGL 138
Cdd:COG4566   80 HGDVPMAVRAMKAGAVDFLEKPFddqaLLDAVRRALARDRARRAERARRAELRARL 135
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
1-108 7.15e-12

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 64.10  E-value: 7.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   1 MNAITRVMVIEDDIAIAELHHRYLeQMGGFDVVGiATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCD 80
Cdd:PRK11361   1 MTAINRILIVDDEDNVRRMLSTAF-ALQGFETHC-ANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTP 78

                         90       100
                 ....*....|....*....|....*...
gi 972365929  81 VILITAARDVDTLQQAMRGGVVDYLLKP 108
Cdd:PRK11361  79 VILMTAYAEVETAVEALRCGAFDYVIKP 106
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 7-113 8.00e-12

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 60.01  E-value: 8.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQmGGFDVVGiATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQgCDVILITA 86
Cdd:cd17623    1 ILLIDDDRELTELLTEYLEM-EGFNVRA-AHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKTSQ-VPVLMLTA 77

                         90       100
                 ....*....|....*....|....*...
gi 972365929  87 -ARDVDTLqQAMRGGVVDYLLKPvMFPR 113
Cdd:cd17623   78 rGDDIDRI-LGLELGADDYLPKP-FNPR 103
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 7-108 8.49e-12

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 59.86  E-value: 8.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQMGgFDVVGiATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITA 86
Cdd:cd19926    1 VLVVDDEPDIRELLEITLGRMG-LDVRS-ARNVKEARELLASEPYDLCLTDMRLPDGSGLELVQHIQQRLPQTPVAVITA 78

                         90       100
                 ....*....|....*....|..
gi 972365929  87 ARDVDTLQQAMRGGVVDYLLKP 108
Cdd:cd19926   79 YGSLDTAIEALKAGAFDFLTKP 100
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 7-108 1.31e-11

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 59.10  E-value: 1.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEqMGGFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQgCDVILITA 86
Cdd:cd17620    1 ILVIEDEPQIRRFLRTALE-AHGYRVF-EAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRLREWSA-VPVIVLSA 77

                         90       100
                 ....*....|....*....|..
gi 972365929  87 ARDVDTLQQAMRGGVVDYLLKP 108
Cdd:cd17620   78 RDEESDKIAALDAGADDYLTKP 99
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 7-120 1.34e-11

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 59.43  E-value: 1.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQMGgFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITA 86
Cdd:cd17550    1 ILIVDDEEDIRESLSGILEDEG-YEVD-TAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIMISG 78

                         90       100       110
                 ....*....|....*....|....*....|....
gi 972365929  87 ARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALKK 120
Cdd:cd17550   79 HGTIETAVKATKLGAYDFIEKPLSLDRLLLTIER 112
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 6-120 1.66e-11

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 59.35  E-value: 1.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDiAIAELHHRYLEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGcDVILIT 85
Cdd:cd19932    2 RVLIAEDE-ALIRMDLREMLEEAGYEVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENIA-PIVLLT 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 972365929  86 AARDVDTLQQAMRGGVVDYLLKPV----MFPRLEAALKK 120
Cdd:cd19932   80 AYSQQDLVERAKEAGAMAYLVKPFsesdLIPAIEMAIAR 118
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 6-118 4.72e-11

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 57.84  E-value: 4.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGgFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILIT 85
Cdd:cd17563    2 SLLLVDDDEVFAERLARALERRG-FEVE-TAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVVLT 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 972365929  86 AARDVDTLQQAMRGGVVDYLLKPVMFPRLEAAL 118
Cdd:cd17563   80 GYASIATAVEAIKLGADDYLAKPADADEILAAL 112
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 24-120 5.00e-11

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 58.05  E-value: 5.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929  24 LEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITAARDVDTLQQAMRGGVVD 103
Cdd:cd19930   18 LELEDDLEVVAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREELPDTKVLIVTTFGRPGYFRRALAAGVDG 97

                         90
                 ....*....|....*..
gi 972365929 104 YLLKPVMFPRLEAALKK 120
Cdd:cd19930   98 YVLKDRPIEELADAIRT 114
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 5-108 5.30e-11

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 58.05  E-value: 5.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   5 TRVMVIEDDIAIAELHHRYLEQmGGFDVVGIATTQsEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILI 84
Cdd:cd19919    1 KTVWIVDDDSSIRWVLERALAG-AGLTVTSFENAQ-EALAALASSQPDVLISDIRMPGMDGLALLAQIKQRHPDLPVIIM 78

                         90       100
                 ....*....|....*....|....
gi 972365929  85 TAARDVDTLQQAMRGGVVDYLLKP 108
Cdd:cd19919   79 TAHSDLDSAVSAYQGGAFEYLPKP 102
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 7-120 1.03e-10

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 57.07  E-value: 1.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQMGGFDVVGIATTQSEALMQLDilKPDLVLLDVYLPDGCGLDILNHVRGSNQgCDVILITA 86
Cdd:cd17594    2 VLVVDDDAAMRHLLILYLRERGFDVTAAADGAEEARLMLHR--RVDLVLLDLRLGQESGLDLLRTIRARSD-VPIIIISG 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 972365929  87 ARDVDTLQQ-AMRGGVVDYLLKPVMFPRLEAALKK 120
Cdd:cd17594   79 DRRDEIDRVvGLELGADDYLAKPFGLRELLARVRA 113
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 6-86 2.71e-10

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 56.08  E-value: 2.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGgFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILIT 85
Cdd:cd17554    2 KILVVDDEENIRELYKEELEDEG-YEVV-TAGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDLPVIICT 79


                 .
gi 972365929  86 A 86
Cdd:cd17554   80 A 80
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 30-121 2.77e-10

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 56.02  E-value: 2.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929  30 FDVVGIATTQ-SEALMQLDILK---PDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITAARDVDTLQQAMRGGVVDYL 105
Cdd:cd17553   20 FNKEGYQTFQaANGLQALDIVTkerPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYGELDMIQESKELGALTHF 99

                         90
                 ....*....|....*.
gi 972365929 106 LKPVMFPRLEAALKKY 121
Cdd:cd17553  100 AKPFDIDEIRDAVKKY 115
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 5-69 3.06e-10

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 56.44  E-value: 3.06e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 972365929   5 TRVMVIEDDIAIAELHHRYLEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDIL 69
Cdd:COG2197    2 IRVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEAL 66
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 7-118 4.31e-10

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 55.55  E-value: 4.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQMGgFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCD---VIL 83
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLLEKLG-YEVD-VAENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIRELEGGGRrtpIIA 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 972365929  84 ITAARDVDTLQQAMRGGVVDYLLKPVMFPRLEAAL 118
Cdd:cd17546   79 LTANALEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 5-119 4.70e-10

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 55.46  E-value: 4.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   5 TRVMVIEDDIAIAELHHRYLEQMGgFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGcdVILI 84
Cdd:cd17622    1 TRILLVEDDPKLARLIADFLESHG-FNVV-VEHRGDRALEVIAREKPDAVLLDIMLPGIDGLTLCRDLRPKYQG--PILL 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 972365929  85 TAARDVDTLQ-QAMRGGVVDYLLKP----VMFPRLEAALK 119
Cdd:cd17622   77 LTALDSDIDHiLGLELGADDYVVKPvepaVLLARLRALLR 116
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 5-110 4.75e-10

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 55.28  E-value: 4.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   5 TRVMVIEDDIAIAELHHRYLEQmGGFDVVGiATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILI 84
Cdd:cd17555    1 ATILVIDDDEVVRESIAAYLED-SGFQVLQ-AADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPDTPVIVV 78

                         90       100
                 ....*....|....*....|....*.
gi 972365929  85 TAARDVDTLQQAMRGGVVDYLLKPVM 110
Cdd:cd17555   79 SGAGVMSDAVEALRLGAWDYLTKPIE 104
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 6-108 1.16e-09

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 54.40  E-value: 1.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQmGGFDVvGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRgSNQGCDVILIT 85
Cdd:cd17626    2 RILVVDDDAALAEMIGIVLRG-EGFDP-AFCGDGTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQIR-AESGVPIVMLT 78

                         90       100
                 ....*....|....*....|...
gi 972365929  86 AARDVDTLQQAMRGGVVDYLLKP 108
Cdd:cd17626   79 AKSDTVDVVLGLESGADDYVAKP 101
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 7-120 1.67e-09

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 53.93  E-value: 1.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEqMGGFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITA 86
Cdd:cd17627    1 ILVVDDDRAVRESLRRSLR-FEGYEVE-TAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLTA 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 972365929  87 ARDVDTLQQAMRGGVVDYLLKPV----MFPRLEAALKK 120
Cdd:cd17627   79 RDSVSDRVAGLDAGADDYLVKPFaleeLLARVRALLRR 116
PRK09191 PRK09191
two-component response regulator; Provisional
 5-86 1.80e-09

two-component response regulator; Provisional


Pssm-ID: 236402 [Multi-domain]  Cd Length: 261  Bit Score: 56.39  E-value: 1.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   5 TRVMVIEDD--IA--IAELhhryLEQMGgFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDG-CGLDILNHVRGSnqgC 79
Cdd:PRK09191 138 TRVLIIEDEpiIAmdLEQL----VESLG-HRVTGIARTRAEAVALAKKTRPGLILADIQLADGsSGIDAVNDILKT---F 209


                 ....*....
gi 972365929  80 D--VILITA 86
Cdd:PRK09191 210 DvpVIFITA 218
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 5-127 1.83e-09

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 55.97  E-value: 1.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   5 TRVMVIEDDIAIAELHHRYLEQMGG--FDvvgiATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRgSNQGCDVI 82
Cdd:PRK10529   2 TNVLIVEDEQAIRRFLRTALEGDGMrvFE----AETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDLR-QWSAIPVI 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 972365929  83 LITAARDVDTLQQAMRGGVVDYLLKPV----MFPRLEAALKKYQSQQQE 127
Cdd:PRK10529  77 VLSARSEESDKIAALDAGADDYLSKPFgigeLQARLRVALRRHSATPAP 125
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 6-120 1.86e-09

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 53.92  E-value: 1.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQmGGFDVvGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRgSNQGCDVILIT 85
Cdd:cd19939    1 RILIVEDELELARLTRDYLIK-AGLEV-SVFTDGQRAVRRIIDEQPSLVVLDIMLPGMDGLTVCREVR-EHSHVPILMLT 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 972365929  86 A-ARDVDTLqQAMRGGVVDYLLKPV----MFPRLEAALKK 120
Cdd:cd19939   78 ArTEEMDRV-LGLEMGADDYLCKPFspreLLARVRALLRR 116
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 6-108 2.05e-09

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 53.71  E-value: 2.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGGFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGS--NQGCDVIL 83
Cdd:cd17552    3 RILVIDDEEDIREVVQACLEKLAGWEVL-TASSGQEGLEKAATEQPDAILLDVMMPDMDGLATLKKLQANpeTQSIPVIL 81

                         90       100
                 ....*....|....*....|....*
gi 972365929  84 ITAARDVDTLQQAMRGGVVDYLLKP 108
Cdd:cd17552   82 LTAKAQPSDRQRFASLGVAGVIAKP 106
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
6-120 2.16e-09

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 55.88  E-value: 2.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQmGGFDVVGiATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCD--VIL 83
Cdd:PRK10161   4 RILVVEDEAPIREMVCFVLEQ-NGFQPVE-AEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKRESMTRDipVVM 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 972365929  84 ITAARDVDTLQQAMRGGVVDYLLKPV----MFPRLEAALKK 120
Cdd:PRK10161  82 LTARGEEEDRVRGLETGADDYITKPFspkeLVARIKAVMRR 122
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 5-110 4.70e-09

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 52.78  E-value: 4.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   5 TRVMVIEDDIAIAELHHRYLEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLP--DgcGLDILNHVRgSNQGCDVI 82
Cdd:cd17541    1 IRVLIVDDSAVMRKLLSRILESDPDIEVVGTARDGEEALEKIKELKPDVITLDIEMPvmD--GLEALRRIM-AERPTPVV 77

                         90       100       110
                 ....*....|....*....|....*....|
gi 972365929  83 LITA--ARDVDTLQQAMRGGVVDYLLKPVM 110
Cdd:cd17541   78 MVSSltEEGAEITLEALELGAVDFIAKPSG 107
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 7-118 5.02e-09

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 52.60  E-value: 5.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQMGgFDVVGIaTTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITA 86
Cdd:cd17537    3 VYVVDDDEAVRDSLAFLLRSVG-LAVKTF-TSASAFLAAAPPDQPGCLVLDVRMPGMSGLELQDELLARGSNIPIIFITG 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 972365929  87 ARDVDTLQQAMRGGVVDYLLKPV----MFPRLEAAL 118
Cdd:cd17537   81 HGDVPMAVEAMKAGAVDFLEKPFrdqvLLDAIEQAL 116
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 6-109 5.82e-09

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 52.11  E-value: 5.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGgFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCD--VIL 83
Cdd:cd17538    1 KILVVDDEPANRELLEALLSAEG-YEVL-TADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLKEDPETRHipVIM 78

                         90       100
                 ....*....|....*....|....*.
gi 972365929  84 ITAARDVDTLQQAMRGGVVDYLLKPV 109
Cdd:cd17538   79 ITALDDREDRIRGLEAGADDFLSKPI 104
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 6-61 6.97e-09

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 50.64  E-value: 6.97e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 972365929     6 RVMVIEDDIAIAELHHRYLEQMGGfdVVGIATTQSEALMQLDILKPDLVLLDVYLP 61
Cdd:smart00448   2 RILVVDDDPLLRELLKALLEKEGY--EVDEATDGEEALELLKEEKPDLILLDIMMP 55
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 7-118 7.43e-09

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 52.08  E-value: 7.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQMGGfdVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILI-- 84
Cdd:cd17580    1 ILVVDDNEDAAEMLALLLELEGA--EVTTAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLRELPWLANTPAIal 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 972365929  85 TA-ARDVDtLQQAMRGGVVDYLLKPVMFPRLEAAL 118
Cdd:cd17580   79 TGyGQPED-RERALEAGFDAHLVKPVDPDELIELI 112
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 5-108 8.65e-09

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 51.84  E-value: 8.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   5 TRVMVIEDDIAIAELHHRYLEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLP--DGCG-LDILNHVRGSNQgCDV 81
Cdd:cd17561    2 IKVLIADDNREFVQLLEEYLNSQPDMEVVGVAHNGQEALELIEEKEPDVLLLDIIMPhlDGIGvLEKLRRMRLEKR-PKI 80

                         90       100
                 ....*....|....*....|....*..
gi 972365929  82 ILITAARDVDTLQQAMRGGVVDYLLKP 108
Cdd:cd17561   81 IMLTAFGQEDITQRAVELGASYYILKP 107
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 7-111 8.70e-09

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 51.86  E-value: 8.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQMGgFDVvgiaTTQSEALMQLDIL-----KPDLVLLDVYLPDGCGLDILNHVRGSnqgCD- 80
Cdd:cd17584    1 VLVVDDDPTCLAILKRMLLRCG-YQV----TTCTDAEEALSMLrenkdEFDLVITDVHMPDMDGFEFLELIRLE---MDl 72

                         90       100       110
                 ....*....|....*....|....*....|..
gi 972365929  81 -VILITAARDVDTLQQAMRGGVVDYLLKPVMF 111
Cdd:cd17584   73 pVIMMSADGSTSTVMKGLAHGACDYLLKPVSI 104
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 7-109 1.54e-08

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 50.97  E-value: 1.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQMGgFDVvGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCD--VILI 84
Cdd:cd19920    1 ILIVDDVPDNLRLLSELLRAAG-YRV-LVATDGQQALQRAQAEPPDLILLDVMMPGMDGFEVCRRLKADPATRHipVIFL 78

                         90       100
                 ....*....|....*....|....*
gi 972365929  85 TAARDVDTLQQAMRGGVVDYLLKPV 109
Cdd:cd19920   79 TALTDTEDKVKGFELGAVDYITKPF 103
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 7-126 1.65e-08

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 54.11  E-value: 1.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQmGGFDVVGIATTQSeALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITA 86
Cdd:PRK10923   6 VWVVDDDSSIRWVLERALAG-AGLTCTTFENGNE-VLEALASKTPDVLLSDIRMPGMDGLALLKQIKQRHPMLPVIIMTA 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 972365929  87 ARDVDTLQQAMRGGVVDYLLKPV----MFPRLEAALKKYQSQQQ 126
Cdd:PRK10923  84 HSDLDAAVSAYQQGAFDYLPKPFdideAVALVERAISHYQEQQQ 127
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 6-119 1.68e-08

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 53.00  E-value: 1.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGGF-DVVGIATTQSEALMQLDIlkpDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILI 84
Cdd:PRK09836   2 KLLIVEDEKKTGEYLTKGLTEAGFVvDLADNGLNGYHLAMTGDY---DLIILDIMLPDVNGWDIVRMLRSANKGMPILLL 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 972365929  85 TAARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALK 119
Cdd:PRK09836  79 TALGTIEHRVKGLELGADDYLVKPFAFAELLARVR 113
ompR PRK09468
osmolarity response regulator; Provisional
 1-108 2.25e-08

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 53.05  E-value: 2.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   1 MNAITRVMVIEDDIAIAELHHRYLEQMgGFDVVGIA-TTQSEALMQLDILkpDLVLLDVYLPDGCGLDILNHVRGSNQGC 79
Cdd:PRK09468   2 MQENYKILVVDDDMRLRALLERYLTEQ-GFQVRSAAnAEQMDRLLTRESF--HLMVLDLMLPGEDGLSICRRLRSQNNPT 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 972365929  80 DVILITA-ARDVDTLqQAMRGGVVDYLLKP 108
Cdd:PRK09468  79 PIIMLTAkGEEVDRI-VGLEIGADDYLPKP 107
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 6-108 2.52e-08

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 50.45  E-value: 2.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQmGGFDVVGIATTQsEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQgCDVILIT 85
Cdd:cd19938    1 RILIVEDEPKLAQLLIDYLRA-AGYAPTLLAHGD-QVLPYVRHTPPDLILLDLMLPGTDGLTLCREIRRFSD-VPIIMVT 77

                         90       100
                 ....*....|....*....|...
gi 972365929  86 AARDVDTLQQAMRGGVVDYLLKP 108
Cdd:cd19938   78 ARVEEIDRLLGLELGADDYICKP 100
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
 7-116 3.31e-08

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 50.12  E-value: 3.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQMGGfdVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRgSNQGCDVILITA 86
Cdd:cd17573    1 ILLIEDDSTLGKEISKGLNEKGY--QADVAESLKDGEYYIDIRNYDLVLVSDKLPDGNGLSIVSRIK-EKHPSIVVIVLS 77

                         90       100       110
                 ....*....|....*....|....*....|..
gi 972365929  87 ARDvDTLQQ--AMRGGVVDYLLKPVMFPRLEA 116
Cdd:cd17573   78 DNP-KTEQEieAFKEGADDYIAKPFDFKVLVA 108
PRK14084 PRK14084
DNA-binding response regulator;
6-200 3.58e-08

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 52.45  E-value: 3.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDD-IAIAELHHrYLEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILI 84
Cdd:PRK14084   2 KALIVDDEpLARNELTY-LLNEIGGFEEINEAENVKETLEALLINQYDIIFLDINLMDESGIELAAKIQKMKEPPAIIFA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929  85 TAArdvDTLQ-QAMRGGVVDYLLKPVMFPRLEAALKKYQSQQQEFESVSDLNqglvdkmlqANAKADSGKVsTLPKGIDg 163
Cdd:PRK14084  81 TAH---DQFAvKAFELNATDYILKPFEQKRIEQAVNKVRATKAKDDNNASAI---------ANDMSANFDQ-SLPIEID- 146

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 972365929 164 vtlDKIRAIFQQadavNITADEAGERIGASRTTARRY 200
Cdd:PRK14084 147 ---DKIHMLNQQ----DIIAIGVHNGITTIHTTNHKY 176
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
 1-137 4.91e-08

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 51.95  E-value: 4.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   1 MNAITRVmviEDDIAIAELHHRYLEQMGgFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCD 80
Cdd:PRK10701   1 MNKIVFV---EDDAEVGSLIAAYLAKHD-IDVT-VEPRGDRAEATILREQPDLVLLDIMLPGKDGMTICRDLRPKWQGPI 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 972365929  81 VILITAARDVDTLqQAMRGGVVDYLLK----PVMFPRLEAALKKYQSQQQEFESVSDLNQG 137
Cdd:PRK10701  76 VLLTSLDSDMNHI-LALEMGACDYILKttppAVLLARLRLHLRQNEQATQTKGLQETSLTP 135
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 8-116 7.16e-08

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 49.53  E-value: 7.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   8 MVIEDDIAIAELHHRYLEQMGGfdVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITAA 87
Cdd:cd17625    1 LVVEDEKDLSEAITKHLKKEGY--TVDVCFDGEEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLREEGIETPVLLLTAL 78

                         90       100
                 ....*....|....*....|....*....
gi 972365929  88 RDVDTLQQAMRGGVVDYLLKPVMFPRLEA 116
Cdd:cd17625   79 DAVEDRVKGLDLGADDYLPKPFSLAELLA 107
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 7-119 8.47e-08

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 49.20  E-value: 8.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAelhHRYLEQMGGFD-VVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGsnQGCDV-ILI 84
Cdd:cd19934    1 LLLVEDDALLA---AQLKEQLSDAGyVVDVAEDGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRS--EGRATpVLI 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 972365929  85 TAARD-----VDTLqqamRGGVVDYLLKPVMFPRLEAALK 119
Cdd:cd19934   76 LTARDswqdkVEGL----DAGADDYLTKPFHIEELLARLR 111
PRK10693 PRK10693
two-component system response regulator RssB;
36-109 9.79e-08

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 51.53  E-value: 9.79e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 972365929  36 ATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITAARDVDTLQQAMRGGVVDYLLKPV 109
Cdd:PRK10693   3 AANGVDALELLGGFTPDLIICDLAMPRMNGIEFVEHLRNRGDQTPVLVISATENMADIAKALRLGVQDVLLKPV 76
PRK10643 PRK10643
two-component system response regulator PmrA;
6-134 9.88e-08

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 50.80  E-value: 9.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGGfdVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRgsNQGCDV-ILI 84
Cdd:PRK10643   2 KILIVEDDTLLLQGLILALQTEGY--ACDCASTAREAEALLESGHYSLVVLDLGLPDEDGLHLLRRWR--QKKYTLpVLI 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 972365929  85 TAARdvDTLQQAMRG---GVVDYLLKPV----MFPRLEAALKKYQSQQQEFESVSDL 134
Cdd:PRK10643  78 LTAR--DTLEDRVAGldvGADDYLVKPFaleeLHARIRALIRRHQGQGENELQVGNL 132
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 29-122 1.09e-07

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 50.80  E-value: 1.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929  29 GFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITAARDVDTLQQAMRGGVVDYLLKP 108
Cdd:PRK10651  31 DITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLSGRIVVFSVSNHEEDVVTALKRGADGYLLKD 110

                         90
                 ....*....|....
gi 972365929 109 vMFPrlEAALKKYQ 122
Cdd:PRK10651 111 -MEP--EDLLKALQ 121
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 7-108 1.36e-07

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 48.21  E-value: 1.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQmGGFdVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITA 86
Cdd:cd19935    1 ILVVEDEKKLAEYLKKGLTE-EGY-AVDVAYDGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAGKQTPVLMLTA 78

                         90       100
                 ....*....|....*....|..
gi 972365929  87 ARDVDTLQQAMRGGVVDYLLKP 108
Cdd:cd19935   79 RDSVEDRVKGLDLGADDYLVKP 100
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
6-127 1.47e-07

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 50.57  E-value: 1.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEqMGGFDVVgIATTQSEALMQLDIlKPDLVLLDVYLPDGCGLDILNHVRGSNQgCDVILIT 85
Cdd:PRK10955   3 KILLVDDDRELTSLLKELLE-MEGFNVI-VAHDGEQALDLLDD-SIDLLLLDVMMPKKNGIDTLKELRQTHQ-TPVIMLT 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 972365929  86 A-ARDVDTLqQAMRGGVVDYLLKPV----MFPRLEAALKK-YQSQQQE 127
Cdd:PRK10955  79 ArGSELDRV-LGLELGADDYLPKPFndreLVARIRAILRRsHWSEQQQ 125
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 7-119 2.24e-07

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 48.05  E-value: 2.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQMGgFDVVGIatTQSEALMQLDI-LKPDLVLLDVYLPDGCGLDILNHVRGSNQgCDVILIT 85
Cdd:cd18159    1 ILIVEDDETIASLLKKHLEKWG-YEVVLI--EDFEDVLEEFLqFKPDLVLLDINLPYFDGFYWCREIRQISN-VPIIFIS 76

                         90       100       110
                 ....*....|....*....|....*....|....
gi 972365929  86 AARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALK 119
Cdd:cd18159   77 SRDDNMDQVMAINMGGDDYITKPFDLDVLLAKIK 110
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 8-119 3.32e-07

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 47.65  E-value: 3.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   8 MVIEDDIAIAELHHRYLEQmGGFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSN--QGCDVILIT 85
Cdd:cd19937    1 LVVDDEEDIVELLKYNLEK-EGYEVV-TAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILRSDPktSSIPIIMLT 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 972365929  86 A-ARDVDTLqQAMRGGVVDYLLKPVMFPRLEAALK 119
Cdd:cd19937   79 AkGEEFDKV-LGLELGADDYITKPFSPRELLARVK 112
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 24-120 5.79e-07

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 46.96  E-value: 5.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929  24 LEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITAARDVDTLQQAMRGGVVD 103
Cdd:cd19931   18 IELDPDFTVVGEASSGEEGIELAERLDPDLILLDLNMKGMSGLDTLKALREEGVSARIVILTVSDAEDDVVTALRAGADG 97

                         90
                 ....*....|....*..
gi 972365929 104 YLLKPVMFPRLEAALKK 120
Cdd:cd19931   98 YLLKDMEPEDLLEALKQ 114
orf27 CHL00148
Ycf27; Reviewed
 6-119 9.45e-07

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 48.17  E-value: 9.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLeQMGGFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNqgcDV--IL 83
Cdd:CHL00148   8 KILVVDDEAYIRKILETRL-SIIGYEVI-TASDGEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEIRKES---DVpiIM 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 972365929  84 ITAARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALK 119
Cdd:CHL00148  83 LTALGDVSDRITGLELGADDYVVKPFSPKELEARIR 118
PRK15479 PRK15479
transcriptional regulator TctD;
6-134 9.71e-07

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 47.79  E-value: 9.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMG-GFDVV--GIATTQseaLMQLDILKpdLVLLDVYLPDGCGLDILNHVRGSNQGCDVI 82
Cdd:PRK15479   2 RLLLAEDNRELAHWLEKALVQNGfAVDCVfdGLAADH---LLQSEMYA--LAVLDINMPGMDGLEVLQRLRKRGQTLPVL 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 972365929  83 LITAARDVDTLQQAMRGGVVDYLLKPVMF----PRLEAALKKYQSQQQEFESVSDL 134
Cdd:PRK15479  77 LLTARSAVADRVKGLNVGADDYLPKPFELeeldARLRALLRRSAGQVQEVQQLGEL 132
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 6-119 1.23e-06

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 46.26  E-value: 1.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGGFDVVGIATTQSEALmqlDIL----------KPDLVLLDVYLPDGCGLDILNHVRGS 75
Cdd:cd17557    1 TILLVEDNPGDAELIQEAFKEAGVPNELHVVRDGEEAL---DFLrgegeyadapRPDLILLDLNMPRMDGFEVLREIKAD 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 972365929  76 NQGCD--VILITAARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALK 119
Cdd:cd17557   78 PDLRRipVVVLTTSDAEEDIERAYELGANSYIVKPVDFEEFVEAIR 123
PRK10336 PRK10336
two-component system response regulator QseB;
6-139 1.29e-06

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 47.58  E-value: 1.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMG-GFDVVGIATTQSEALMQLDIlkpDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILI 84
Cdd:PRK10336   2 RILLIEDDMLIGDGIKTGLSKMGfSVDWFTQGRQGKEALYSAPY---DAVILDLTLPGMDGRDILREWREKGQREPVLIL 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 972365929  85 TAARDVDTLQQAMRGGVVDYLLKPVMF----PRLEAALKKYQSQqqefeSVSDLNQGLV 139
Cdd:PRK10336  79 TARDALAERVEGLRLGADDYLCKPFALievaARLEALMRRTNGQ-----ASNELRHGNV 132
fixJ PRK09390
response regulator FixJ; Provisional
 7-119 1.38e-06

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 47.30  E-value: 1.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAElHHRYLEQMGGFDVVGIATTQSeALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITA 86
Cdd:PRK09390   6 VHVVDDDEAMRD-SLAFLLDSAGFEVRLFESAQA-FLDALPGLRFGCVVTDVRMPGIDGIELLRRLKARGSPLPVIVMTG 83

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 972365929  87 ARDVDTLQQAMRGGVVDYLLKP----VMFPRLEAALK 119
Cdd:PRK09390  84 HGDVPLAVEAMKLGAVDFIEKPfedeRLIGAIERALA 120
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
6-107 1.94e-06

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 47.15  E-value: 1.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILIT 85
Cdd:PRK10403   8 QVLIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILT 87

                         90       100
                 ....*....|....*....|....*
gi 972365929  86 ---AARDVDTLQQAmrgGVVDYLLK 107
Cdd:PRK10403  88 vsdASSDVFALIDA---GADGYLLK 109
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 6-120 2.25e-06

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 45.22  E-value: 2.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEqMGGFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCD--VIL 83
Cdd:cd17548    1 KILIVEDNPLNMKLARDLLE-SAGYEVL-EAADGEEALEIARKEKPDLILMDIQLPGMDGLEATRLLKEDPATRDipVIA 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 972365929  84 ITAARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALKK 120
Cdd:cd17548   79 LTAYAMKGDREKILEAGCDGYISKPIDTREFLETVAK 115
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 7-108 2.30e-06

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 45.06  E-value: 2.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQMGgFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCD--VILI 84
Cdd:cd19927    1 ILLVDDDPGIRLAVKDYLEDQG-FTVI-AASNGLEALDLLNQYIPDLIISDIIMPGVDGYSLLGKLRKNADFDTipVIFL 78

                         90       100
                 ....*....|....*....|....
gi 972365929  85 TAARDVDTLQQAMRGGVVDYLLKP 108
Cdd:cd19927   79 TAKGMTSDRIKGYNAGCDGYLSKP 102
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
 7-108 2.52e-06

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 44.80  E-value: 2.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQMGgFDVVgiATTQSEALMQ-LDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILIT 85
Cdd:cd19928    1 ILVADDDRAIRTVLTQALGRAG-YEVR--TTGNAATLWRwVEEGEGDLVITDVVMPDENGLDLIPRIKKARPDLPIIVMS 77

                         90       100
                 ....*....|....*....|...
gi 972365929  86 AARDVDTLQQAMRGGVVDYLLKP 108
Cdd:cd19928   78 AQNTLMTAVKAAERGAFEYLPKP 100
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 7-108 2.58e-06

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 44.67  E-value: 2.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQMGgFDVVGIaTTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDV-ILIT 85
Cdd:cd17602    1 VACVDDRPSIQKMIEYFLEKQG-FRVVVI-DDPLRALTTLLNSKPDLILIDIDMPDLDGYELCSLLRKSSALKDTpIIML 78

                         90       100
                 ....*....|....*....|....*
gi 972365929  86 AARD--VDTLQQAMRGGvVDYLLKP 108
Cdd:cd17602   79 TGKDglVDRIRAKMAGA-SGYLTKP 102
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 7-108 2.99e-06

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 44.50  E-value: 2.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAElHHRYLEQMGGFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQgCDVILITA 86
Cdd:cd17621    1 VLVVEDEESFSD-PLAYLLRKEGFEVT-VATDGPAALAEFDRAGADIVLLDLMLPGLSGTEVCRQLRARSN-VPVIMVTA 77

                         90       100
                 ....*....|....*....|..
gi 972365929  87 ARDVDTLQQAMRGGVVDYLLKP 108
Cdd:cd17621   78 KDSEIDKVVGLELGADDYVTKP 99
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
 8-109 3.51e-06

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 44.19  E-value: 3.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   8 MVIEDDIAIAELHHRYLEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITAA 87
Cdd:cd17565    2 YIVDDDKNIIKILSDIIEDDDLGEVVGEADNGAQAYDEILFLQPDIVLIDLLMPGMDGIQLVRKLKDTGSNGKFIMISQV 81

                         90       100
                 ....*....|....*....|..
gi 972365929  88 RDVDTLQQAMRGGVVDYLLKPV 109
Cdd:cd17565   82 SDKEMIGKAYQAGIEFFINKPI 103
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 7-120 2.59e-05

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 42.41  E-value: 2.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQMGgFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQgCDVILITA 86
Cdd:cd17614    1 ILVVDDEKPISDILKFNLTKEG-YEVV-TAYDGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTSN-VPIIMLTA 77

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 972365929  87 A-RDVDTLqQAMRGGVVDYLLKPV----MFPRLEAALKK 120
Cdd:cd17614   78 KdSEVDKV-LGLELGADDYVTKPFsnreLLARVKANLRR 115
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 6-117 3.49e-05

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 43.41  E-value: 3.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHhRYLEQMGGFDVVGIaTTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILIT 85
Cdd:PRK11083   5 TILLVEDEQAIADTL-VYALQSEGFTVEWF-ERGLPALDKLRQQPPDLVILDVGLPDISGFELCRQLLAFHPALPVIFLT 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 972365929  86 AARD-VDTLqQAMRGGVVDYLLKPvmF-PRLEAA 117
Cdd:PRK11083  83 ARSDeVDRL-VGLEIGADDYVAKP--FsPREVAA 113
PRK11697 PRK11697
two-component system response regulator BtsR;
6-120 4.55e-05

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 43.30  E-value: 4.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDD-IAIAELHHRyLEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGcDVILI 84
Cdd:PRK11697   3 KVLIVDDEpLAREELREL-LQEEGDIEIVGECSNAIEAIGAIHRLKPDVVFLDIQMPRISGLELVGMLDPEHMP-YIVFV 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 972365929  85 TAARDVDTlqQAMRGGVVDYLLKPVMFPRLEAALKK 120
Cdd:PRK11697  81 TAFDEYAI--KAFEEHAFDYLLKPIDPARLAKTLAR 114
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 7-108 5.05e-05

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 41.24  E-value: 5.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQMGGfdVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITA 86
Cdd:cd17616    1 VLLIEDDSATAQSIELMLKSEGF--NVYTTDLGEEGLDLGKLYDYDIILLDLNLPDMSGYEVLRTLRLAKVKTPILILSG 78

                         90       100
                 ....*....|....*....|..
gi 972365929  87 ARDVDTLQQAMRGGVVDYLLKP 108
Cdd:cd17616   79 LADIEDKVKGLGFGADDYMTKP 100
PRK13435 PRK13435
response regulator; Provisional
 5-86 5.28e-05

response regulator; Provisional


Pssm-ID: 184052 [Multi-domain]  Cd Length: 145  Bit Score: 41.96  E-value: 5.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   5 TRVMVIEDDIAIAELHHRYLEQMGgFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDG-CGLDILNHVrGSNQGCDVIL 83
Cdd:PRK13435   6 LKVLIVEDEALIALELEKLVEEAG-HEVVGIAMSSEQAIALGRRRQPDVALVDVHLADGpTGVEVARRL-SADGGVEVVF 83


                 ...
gi 972365929  84 ITA 86
Cdd:PRK13435  84 MTG 86
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 24-144 6.12e-05

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 43.39  E-value: 6.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929  24 LEQMGgfDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVR---GSNQGCDVILITA--ARDVDTLQQAmr 98
Cdd:PRK11091 545 LEKLG--NSVDVAMTGKEALEMFDPDEYDLVLLDIQLPDMTGLDIARELReryPREDLPPLVALTAnvLKDKKEYLDA-- 620

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 972365929  99 gGVVDYLLKPVMFPRLEAALKKY-------QSQQQEFESVSDLNQGLVDKMLQ 144
Cdd:PRK11091 621 -GMDDVLSKPLSVPALTAMIKKFwdtqddeESTVTTEESSKANEALLDIPMLE 672
REC_1_GGDEF cd19921
first phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 6-107 6.46e-05

first phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes the first REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381148 [Multi-domain]  Cd Length: 115  Bit Score: 41.01  E-value: 6.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGGFDVVgIATTQSEALMQL----DILkpdLVLLDVYLPDGCGLDILNHVrgSNQGCDV 81
Cdd:cd19921    1 KVLIVEDSKTFSKVLKHLIAQELGLEVD-VAETLAEAKALLeegdDYF---AALVDLNLPDAPNGEAVDLV--LEKGIPV 74

                         90       100
                 ....*....|....*....|....*.
gi 972365929  82 ILITAARDVDTLQQAMRGGVVDYLLK 107
Cdd:cd19921   75 IVLTGSFDEDKRETLLSKGVVDYVLK 100
PRK10610 PRK10610
chemotaxis protein CheY;
6-120 8.14e-05

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 41.11  E-value: 8.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGgFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVR--GSNQGCDVIL 83
Cdd:PRK10610   7 KFLVVDDFSTMRRIVRNLLKELG-FNNVEEAEDGVDALNKLQAGGFGFVISDWNMPNMDGLELLKTIRadGAMSALPVLM 85

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 972365929  84 ITAARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALKK 120
Cdd:PRK10610  86 VTAEAKKENIIAAAQAGASGYVVKPFTAATLEEKLNK 122
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 6-108 8.73e-05

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 40.83  E-value: 8.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQmGGFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQgCDVILIT 85
Cdd:cd17619    2 HILIVEDEPVTRATLKSYFEQ-EGYDVS-EAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELREQSE-VGIILVT 78

                         90       100
                 ....*....|....*....|....
gi 972365929  86 A-ARDVDTLqQAMRGGVVDYLLKP 108
Cdd:cd17619   79 GrDDEVDRI-VGLEIGADDYVTKP 101
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 7-108 1.07e-04

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 40.12  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   7 VMVIEDDIAIAELHHRYLEQMGgFDVVGIATTQSeALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQgCDVILITA 86
Cdd:cd19936    1 IALVDDDRNILTSVSMALEAEG-FSVETYTDGAS-ALDGLNARPPDLAILDIKMPRMDGMELLQRLRQKST-LPVIFLTS 77

                         90       100
                 ....*....|....*....|...
gi 972365929  87 ARD-VDTLqQAMRGGVVDYLLKP 108
Cdd:cd19936   78 KDDeIDEV-FGLRMGADDYITKP 99
REC_RocR cd17530
phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR ...
 6-123 1.23e-04

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381086 [Multi-domain]  Cd Length: 123  Bit Score: 40.50  E-value: 1.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGGfDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILIT 85
Cdd:cd17530    2 RVLVLDDDPFQCMMAATILEDLGP-GNVDEADDGREALVILLCNAPDIIICDLKMPDMDGIEFLRHLAESHSNAAVILMS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 972365929  86 AA-----RDVDTLQQAMRGGVVDYLLKPVMFPRLEAALKKYQS 123
Cdd:cd17530   81 GLdggilESAETLAGANGLNLLGTLSKPFSPEELTELLTKYTA 123
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 6-120 1.69e-04

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 40.01  E-value: 1.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGgFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCD--VIL 83
Cdd:cd19923    2 KVLVVDDFSTMRRIIKNLLKELG-FNNVEEAEDGVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIRADGALSHlpVLM 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 972365929  84 ITAARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALKK 120
Cdd:cd19923   81 VTAEAKKENVIAAAQAGVNNYIVKPFTAATLKEKLEK 117
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
10-110 5.85e-04

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 40.25  E-value: 5.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929  10 IEDDIAIA-ELHHRYLEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQgCDVILITA-- 86
Cdd:PRK12555   5 IVNDSPLAvEALRRALARDPDHEVVWVATDGAQAVERCAAQPPDVILMDLEMPRMDGVEATRRIMAERP-CPILIVTSlt 83

                         90       100
                 ....*....|....*....|....
gi 972365929  87 ARDVDTLQQAMRGGVVDYLLKPVM 110
Cdd:PRK12555  84 ERNASRVFEAMGAGALDAVDTPTL 107
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
1-89 6.91e-04

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 39.49  E-value: 6.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   1 MNAItrvmvIEDDIAIAELHHRYLEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCD 80
Cdd:PRK09958   1 MNAI-----IIDDHPLAIAAIRNLLIKNDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGI 75


                 ....*....
gi 972365929  81 VILITAARD 89
Cdd:PRK09958  76 IIIVSAKND 84
CitT pfam12431
Transcriptional regulator; This domain family is found in bacteria, and is approximately 30 ...
 134-164 7.67e-04

Transcriptional regulator; This domain family is found in bacteria, and is approximately 30 amino acids in length. The family is found in association with pfam00072. There is a single completely conserved residue G that may be functionally important. CitT is a transcriptional regulator which allows transcription of the citM gene which codes for the secondary transporter in the Mg-citrate transport complex.


Pssm-ID: 432549  Cd Length: 30  Bit Score: 35.92  E-value: 7.67e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 972365929  134 LNQGLVDKMLQANAKADSGKvSTLPKGIDGV 164
Cdd:pfam12431   1 VDQSDVDRLFQLQAKGAPPS-GDLPKGIDKL 30
PRK15115 PRK15115
response regulator GlrR; Provisional
 6-119 7.70e-04

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 40.21  E-value: 7.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQMGgFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILIT 85
Cdd:PRK15115   7 HLLLVDDDPGLLKLLGMRLTSEG-YSVV-TAESGQEALRVLNREKVDLVISDLRMDEMDGMQLFAEIQKVQPGMPVIILT 84

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 972365929  86 AARDVDTLQQAMRGGVVDYLLKPV----MFPRLEAALK 119
Cdd:PRK15115  85 AHGSIPDAVAATQQGVFSFLTKPVdrdaLYKAIDDALE 122
PRK11517 PRK11517
DNA-binding response regulator HprR;
53-119 9.21e-04

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 39.11  E-value: 9.21e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 972365929  53 LVLLDVYLPDGCGLDILNHVRGSNQgCDVILITAARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALK 119
Cdd:PRK11517  47 LIILDIMLPGMDGWQILQTLRTAKQ-TPVICLTARDSVDDRVRGLDSGANDYLVKPFSFSELLARVR 112
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 36-121 1.05e-03

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 37.52  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929  36 ATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILITAardvDTLQQAMRG----GVVDYLLKPVMF 111
Cdd:cd17593   31 AENGEEALEILREGRIDVLFLDLTMPVMDGYEVLEALPVEQLETKVIVVSG----DVQPEAKERvlelGALAFLKKPFDP 106

                         90
                 ....*....|
gi 972365929 112 PRLEAALKKY 121
Cdd:cd17593  107 EKLAQLLEEL 116
PRK15369 PRK15369
two component system response regulator;
5-119 1.38e-03

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 38.52  E-value: 1.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   5 TRVMVIEDDIAIAELHHRYLEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILI 84
Cdd:PRK15369   4 YKILLVDDHELIINGIKNMLAPYPRYKIVGQVDNGLEVYNACRQLEPDIVILDLGLPGMNGLDVIPQLHQRWPAMNILVL 83

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 972365929  85 TAARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALK 119
Cdd:PRK15369  84 TARQEEHMASRTLAAGALGYVLKKSPQQILLAAIQ 118
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
1-110 2.01e-03

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 38.59  E-value: 2.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   1 MNAItRVMVIEDDIAIAELHHRYLEQMGGFDVVGIATTQSEALMQLDILKPDLVLLDVYLPDGCGLD----ILNHVRgsn 76
Cdd:PRK00742   1 MMKI-RVLVVDDSAFMRRLISEILNSDPDIEVVGTAPDGLEAREKIKKLNPDVITLDVEMPVMDGLDalekIMRLRP--- 76

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 972365929  77 qgCDVILITA--ARDVDTLQQAMRGGVVDYLLKPVM 110
Cdd:PRK00742  77 --TPVVMVSSltERGAEITLRALELGAVDFVTKPFL 110
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
 6-108 4.05e-03

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 36.19  E-value: 4.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQmgGFDVVGIATTQsEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRGSNQGCDVILIT 85
Cdd:cd17596    2 TILVVDDEVRSLEALRRTLEE--DFDVLTAASAE-EALAILEEEWVQVILCDQRMPGTTGVEFLKEVRERWPEVVRIIIS 78

                         90       100
                 ....*....|....*....|....
gi 972365929  86 AARDVDTLQQAMR-GGVVDYLLKP 108
Cdd:cd17596   79 GYTDSEDIIAGINeAGIYQYLTKP 102
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 6-120 5.23e-03

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 35.74  E-value: 5.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972365929   6 RVMVIEDDIAIAELHHRYLEQmGGFDVVgIATTQSEALMQLDILKPDLVLLDVYLPDGCGLDILNHVRG--SNQGCDVIL 83
Cdd:cd17562    2 KILAVDDSASIRQMVSFTLRG-AGYEVV-EAADGRDALSKAQSKKFDLIITDQNMPNMDGIELIKELRKlpAYKFTPILM 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 972365929  84 ITAARDVDTLQQAMRGGVVDYLLKPVMFPRLEAALKK 120
Cdd:cd17562   80 LTTESSDEKKQEGKAAGATGWLVKPFDPEQLLEVVKK 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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