|
Name |
Accession |
Description |
Interval |
E-value |
| ThrB |
COG0083 |
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ... |
5-300 |
5.54e-123 |
|
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis
Pssm-ID: 439853 [Multi-domain] Cd Length: 302 Bit Score: 354.02 E-value: 5.54e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 5 LHLKVPASTANLGVGFDSIGMALNKFLVITAKRNDQQRWRFKHLGPNVDELPNDETHYIYQIAQRVASRYDITLPCLDIE 84
Cdd:COG0083 3 VKVRVPATSANLGPGFDSLGLALSLYDEVEVERSDEPGLEIEIEGEGADELPTDEDNLVYQAALALLEKLGKEPPGLRIE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 85 MRSDIPMARGLGSSASALVAALYIANHFGALQLSKYELLQLATEFEGHPDNVAPTIYGGLVVGYFDPktGDTDISYIDVP 164
Cdd:COG0083 83 IEKGIPLGRGLGSSAAAIVAGLVAANALLGLPLSKEELLELATEGEGHPDNVAPALLGGLVLSRSDG--EPVRVVRLPVP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 165 K-VDVVITVPSYELKTTEARQALPATMTHQQAVQSSAISNTMISVLIQHNYTLAGKMMeQDQLHEPYRQSLIPEFAEIKQ 243
Cdd:COG0083 161 PdLKAVVVIPDFELSTKEARAVLPKQVPLKDAVFNSSRAALLVAALATGDYELLGRAM-EDRLHEPYRAKLIPGFDEVKE 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 973245899 244 LAKSLHAYATVISGAGPTVLTLVHQAHSGELVRTLRSHFPA----CTSEIVTINESGIVTE 300
Cdd:COG0083 240 AALEAGALGAGISGAGPTVLALADDEEAEAVAEAMKAAFAEagidARVYVLKIDNEGARVL 300
|
|
| PRK01212 |
PRK01212 |
homoserine kinase; Provisional |
8-300 |
8.83e-119 |
|
homoserine kinase; Provisional
Pssm-ID: 234920 [Multi-domain] Cd Length: 301 Bit Score: 343.28 E-value: 8.83e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 8 KVPASTANLGVGFDSIGMALNKFLVITAKRNDQ--QRWRFKHLGPNVDELPND-ETHYIYQIAQRVASRYDiTLPCLDIE 84
Cdd:PRK01212 7 RVPATSANLGPGFDSLGLALSLYDEVLVGDVVSveAEFSIEVIGEGADKLPLDpEKNLVYQAALKFLEKLG-KPPGLRIE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 85 MRSDIPMARGLGSSASALVAALYIANHFGALQLSKYELLQLATEFEGHPDNVAPTIYGGLVVGYfdpKTGDTDISYIDVP 164
Cdd:PRK01212 86 LEKNIPLGRGLGSSAASIVAGLVAANELAGLPLSKEELLQLATEGEGHPDNVAPALLGGLVLAL---EENGVISVKIPVF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 165 K-VDVVITVPSYELKTTEARQALPATMTHQQAVQSSAISNTMISVLIQHNYTLAGKMMeQDQLHEPYRQSLIPEFAEIKQ 243
Cdd:PRK01212 163 DdLKWVVAIPNIELSTAEARAVLPKQYSLKDAVFNSSRAALLVAALYTGDYELAGRAM-KDVLHEPYRAKLIPGFAEVRQ 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 244 LAKSLHAYATVISGAGPTVLTLVHQAHSGELVRTLRSHF---PACTSEIVTINESGIVTE 300
Cdd:PRK01212 242 AALEAGALGAGISGAGPTVFALCDKEDAEKVADALQKAFlqgIEGFVHVLRLDTAGARVL 301
|
|
| thrB |
TIGR00191 |
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine ... |
8-265 |
2.69e-74 |
|
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 129295 [Multi-domain] Cd Length: 302 Bit Score: 230.37 E-value: 2.69e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 8 KVPASTANLGVGFDSIGMALNKF--LVITAKRNDQQRW-RFKHLGPNVDELPNDET-HYIYQIAQRVASRYDITLPCLDI 83
Cdd:TIGR00191 4 KVPASSANLGPGFDVLGAALSLYlgLTVTDVVAQESDDtEIEAEGEGVEKIPTEPTdNLIYQVAKRFLDQLGIRMPPVKV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 84 EMRSDIPMARGLGSSASALVAALYIANHFGALQLSKYELLQLATEFEGHPDNVAPTIYGGLVVGYfdpKTGDTDISyIDV 163
Cdd:TIGR00191 84 TLEKNIPLGRGLGSSAAAIVAALAAANELCGLPLSKERLLDYASELEGHPDNVAPALLGGFQLAF---VEDDKLEV-LKI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 164 P---KVDVVITVPSYELKTTEARQALPATMTHQQAVQSSAISNTMISVLIQHNYTLAGKMMeQDQLHEPYRQSLIPEFAE 240
Cdd:TIGR00191 160 PifsKLDWVLAIPNIEVSTAEARAVLPKAYPRQDLVFNLSHLAGLVHAIYQKKPDLGAIMM-KDRIHQPYRESLIPNLFK 238
|
250 260
....*....|....*....|....*
gi 973245899 241 IKQLAKSLHAYATVISGAGPTVLTL 265
Cdd:TIGR00191 239 IKQAALEKGAYGITISGSGPTILAM 263
|
|
| GHMP_kinases_N |
pfam00288 |
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ... |
82-143 |
1.54e-13 |
|
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.
Pssm-ID: 395225 [Multi-domain] Cd Length: 64 Bit Score: 64.49 E-value: 1.54e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 973245899 82 DIEMRSDIPMARGLGSSASALVAALYIANHFGALQLSK--YELLQLATEFEGHPDNVAPTIYGG 143
Cdd:pfam00288 1 DIEIESNIPLGAGLGSSAALAVALLLALNELFGLPLAKlaLEAEELAGGGRGGGMDVAASLYGG 64
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| ThrB |
COG0083 |
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ... |
5-300 |
5.54e-123 |
|
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis
Pssm-ID: 439853 [Multi-domain] Cd Length: 302 Bit Score: 354.02 E-value: 5.54e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 5 LHLKVPASTANLGVGFDSIGMALNKFLVITAKRNDQQRWRFKHLGPNVDELPNDETHYIYQIAQRVASRYDITLPCLDIE 84
Cdd:COG0083 3 VKVRVPATSANLGPGFDSLGLALSLYDEVEVERSDEPGLEIEIEGEGADELPTDEDNLVYQAALALLEKLGKEPPGLRIE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 85 MRSDIPMARGLGSSASALVAALYIANHFGALQLSKYELLQLATEFEGHPDNVAPTIYGGLVVGYFDPktGDTDISYIDVP 164
Cdd:COG0083 83 IEKGIPLGRGLGSSAAAIVAGLVAANALLGLPLSKEELLELATEGEGHPDNVAPALLGGLVLSRSDG--EPVRVVRLPVP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 165 K-VDVVITVPSYELKTTEARQALPATMTHQQAVQSSAISNTMISVLIQHNYTLAGKMMeQDQLHEPYRQSLIPEFAEIKQ 243
Cdd:COG0083 161 PdLKAVVVIPDFELSTKEARAVLPKQVPLKDAVFNSSRAALLVAALATGDYELLGRAM-EDRLHEPYRAKLIPGFDEVKE 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 973245899 244 LAKSLHAYATVISGAGPTVLTLVHQAHSGELVRTLRSHFPA----CTSEIVTINESGIVTE 300
Cdd:COG0083 240 AALEAGALGAGISGAGPTVLALADDEEAEAVAEAMKAAFAEagidARVYVLKIDNEGARVL 300
|
|
| PRK01212 |
PRK01212 |
homoserine kinase; Provisional |
8-300 |
8.83e-119 |
|
homoserine kinase; Provisional
Pssm-ID: 234920 [Multi-domain] Cd Length: 301 Bit Score: 343.28 E-value: 8.83e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 8 KVPASTANLGVGFDSIGMALNKFLVITAKRNDQ--QRWRFKHLGPNVDELPND-ETHYIYQIAQRVASRYDiTLPCLDIE 84
Cdd:PRK01212 7 RVPATSANLGPGFDSLGLALSLYDEVLVGDVVSveAEFSIEVIGEGADKLPLDpEKNLVYQAALKFLEKLG-KPPGLRIE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 85 MRSDIPMARGLGSSASALVAALYIANHFGALQLSKYELLQLATEFEGHPDNVAPTIYGGLVVGYfdpKTGDTDISYIDVP 164
Cdd:PRK01212 86 LEKNIPLGRGLGSSAASIVAGLVAANELAGLPLSKEELLQLATEGEGHPDNVAPALLGGLVLAL---EENGVISVKIPVF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 165 K-VDVVITVPSYELKTTEARQALPATMTHQQAVQSSAISNTMISVLIQHNYTLAGKMMeQDQLHEPYRQSLIPEFAEIKQ 243
Cdd:PRK01212 163 DdLKWVVAIPNIELSTAEARAVLPKQYSLKDAVFNSSRAALLVAALYTGDYELAGRAM-KDVLHEPYRAKLIPGFAEVRQ 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 244 LAKSLHAYATVISGAGPTVLTLVHQAHSGELVRTLRSHF---PACTSEIVTINESGIVTE 300
Cdd:PRK01212 242 AALEAGALGAGISGAGPTVFALCDKEDAEKVADALQKAFlqgIEGFVHVLRLDTAGARVL 301
|
|
| thrB |
TIGR00191 |
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine ... |
8-265 |
2.69e-74 |
|
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 129295 [Multi-domain] Cd Length: 302 Bit Score: 230.37 E-value: 2.69e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 8 KVPASTANLGVGFDSIGMALNKF--LVITAKRNDQQRW-RFKHLGPNVDELPNDET-HYIYQIAQRVASRYDITLPCLDI 83
Cdd:TIGR00191 4 KVPASSANLGPGFDVLGAALSLYlgLTVTDVVAQESDDtEIEAEGEGVEKIPTEPTdNLIYQVAKRFLDQLGIRMPPVKV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 84 EMRSDIPMARGLGSSASALVAALYIANHFGALQLSKYELLQLATEFEGHPDNVAPTIYGGLVVGYfdpKTGDTDISyIDV 163
Cdd:TIGR00191 84 TLEKNIPLGRGLGSSAAAIVAALAAANELCGLPLSKERLLDYASELEGHPDNVAPALLGGFQLAF---VEDDKLEV-LKI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 164 P---KVDVVITVPSYELKTTEARQALPATMTHQQAVQSSAISNTMISVLIQHNYTLAGKMMeQDQLHEPYRQSLIPEFAE 240
Cdd:TIGR00191 160 PifsKLDWVLAIPNIEVSTAEARAVLPKAYPRQDLVFNLSHLAGLVHAIYQKKPDLGAIMM-KDRIHQPYRESLIPNLFK 238
|
250 260
....*....|....*....|....*
gi 973245899 241 IKQLAKSLHAYATVISGAGPTVLTL 265
Cdd:TIGR00191 239 IKQAALEKGAYGITISGSGPTILAM 263
|
|
| PTZ00299 |
PTZ00299 |
homoserine kinase; Provisional |
7-270 |
3.76e-31 |
|
homoserine kinase; Provisional
Pssm-ID: 140320 Cd Length: 336 Bit Score: 119.22 E-value: 3.76e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 7 LKVPASTANLGVGFDSIGMALNKFLVITAKRNDQqrWRFKHLGPNVDELPNDETHYIYQIAQRVASRY-DITLPCLDIEM 85
Cdd:PTZ00299 10 LRVPATTANIGPAYDTLGMALSIFMELTVEHADA--FSMTVEGEGSEHISTDEDNMVVQACRLAFEEYaHKSMPPLKFIM 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 86 RSDIPMARGLGSSASALVAALYIANHFGALQL---SKYELLQLATEFEGHPDNVAPTIYGGLVVGYfdPKTGDTDISYiD 162
Cdd:PTZ00299 88 HSNIPYGCGCGSSSAAAVAGFVAGMKLCGLTMeteNEEALLQAIAKFEGHPDNAAPAIYGGIQLVY--KKDNGRFLTY-R 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 163 VP---KVDVVITVPSYELK--TTEARQALPATMTHQQAVQSsaISNTMISVLIQHNYTLAGKMMEQDQLHEPYRQS-LIP 236
Cdd:PTZ00299 165 VPtppNLSVVLFVPHNKMKanTHVTRNLIPTSVSLEDAVFN--ISRTSILVLALSTGDLRMLKSCSDKLHEQQRSDaLFP 242
|
250 260 270
....*....|....*....|....*....|....
gi 973245899 237 EFAEIKQLAKSLHAYATVISGAGPTVLTLVHQAH 270
Cdd:PTZ00299 243 HFRPCVKAAREAGAHYAFLSGAGPSVCALVGGRH 276
|
|
| PLN02451 |
PLN02451 |
homoserine kinase |
10-275 |
1.17e-24 |
|
homoserine kinase
Pssm-ID: 215248 Cd Length: 370 Bit Score: 102.18 E-value: 1.17e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 10 PASTANLGVGFDSIGMA---LNKFlvITAKRNDQQR---WRFKHLGPNVDELPNDETHYIYQIAQRVASR-YDITLPCLD 82
Cdd:PLN02451 59 PATVANLGPGFDFLGCAvdgLGDF--VTARVDPGVRpgeVSISEITGDTGRLSKDPLRNCAGIAAIATMKlLGIRSVGLS 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 83 IEMRSDIPMARGLGSSA-SALVAALYIANHFGAlQLSKYELLQLATEFEG-----HPDNVAPTIYGGLV-VGYFDP---- 151
Cdd:PLN02451 137 LSLHKGLPLGSGLGSSAaSAAAAAVAVNELFGS-PLGKDDLVLAGLESEAkvsgyHADNIAPALMGGFVlIRSYEPlhli 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 152 ---KTGDTDISYidvpkvdvVITVPSYELKTTEARQALPATMTHQQAVQSSAISNTMISVLIQHNYTLAGKMMEQDQLHE 228
Cdd:PLN02451 216 plrFPSAKDLFF--------VLVSPDFEAPTKKMRAALPKEIPMKHHVWNCSQAAALVAAILQGDAVLLGEALSSDKIVE 287
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 973245899 229 PYRQSLIPEFAEIKQLAKSLHAYATVISGAGPTVLTLVHQAHSGELV 275
Cdd:PLN02451 288 PTRAPLIPGMEAVKKAALEAGAYGCTISGAGPTAVAVIDDEEKGEEV 334
|
|
| ERG12 |
COG1577 |
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ... |
22-259 |
1.41e-22 |
|
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis
Pssm-ID: 441185 [Multi-domain] Cd Length: 277 Bit Score: 94.52 E-value: 1.41e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 22 SIGMALNKFLVITAKRNDQQRWRFK----HLGPNVDELPNDETHYIYQIAQRVASRYDITLPCLDIEMRSDIPMARGLGS 97
Cdd:COG1577 19 AIAVAVDRRATVTVEPSDDDKLRIEspdlGGTLDLDPLADAALRYIKAAIEAALEYLGLPLKGFDIEIDSEIPRKRGLGS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 98 SASALVAAL-YIANHFGaLQLSKYELLQLA--TEFEGHP-----DNVApTIYGGLVvgYFDPKTGDTDisyIDVPK-VDV 168
Cdd:COG1577 99 SAAVAVAVIrALAAFYG-VELSKEELFKLAleAEKIVHGnpsglDTAA-STYGGPI--YYQRGDRAEP---LELPKnLPL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 169 VI---TVPSyelKTTEA-------RQALPATMTHQQAvQSSAISNTMISVLIQHNYTLAGKMMEQDQLHepyRQSL---I 235
Cdd:COG1577 172 VVgdtGVPA---STKELvakvrklKERNPELYEAFLE-EIGDLVEEAIEALEEGDLEALGELMNENHGL---LRALgvsT 244
|
250 260
....*....|....*....|....
gi 973245899 236 PEFAEIKQLAKSLHAYATVISGAG 259
Cdd:COG1577 245 PELDRLVEAARKAGALGAKLTGAG 268
|
|
| PduX |
COG4542 |
PduX protein involved in propanediol utilization and related proteins [Secondary metabolites ... |
65-292 |
1.34e-14 |
|
PduX protein involved in propanediol utilization and related proteins [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 443608 [Multi-domain] Cd Length: 286 Bit Score: 72.58 E-value: 1.34e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 65 QIAQRVASRYDITLPCLDIEMRSDIPMARGLGSSASALVAALYIANHFGALQLSKYELLQLATEFEghP-DnvaPTIYGG 143
Cdd:COG4542 55 RAAELTLEHLGLPPLGGRIELRSDIPVGKGMASSTADIAATARAVARALGKELSPEELARLAVAIE--PtD---STMFPG 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 144 LVVgyFDPKTGDTDISYIDVPKVDVVITVPSYELKTTEARQALPATMTHQQAVQSSAISNTMISVLIQHNYTLAGKMMEQ 223
Cdd:COG4542 130 LVL--FDHREGRVLEPLGPLPPLDILGLDSGGTVDTLAFNRRDLAELNRAEEPEIERALALLREALRTGDLALLGEAATL 207
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 973245899 224 D----QLHEPYrqsliPEFAEIKQLAKSLHAYATVI--SGagpTVLTLV---HQAHSGELVRTLRSHFPACTSEIVTI 292
Cdd:COG4542 208 SaranQRILPK-----PELEELLALAEELGALGVNVahSG---TVLGLLfdpGDHDVEKLAEALRRRLLRLGYPRIGL 277
|
|
| GHMP_kinases_N |
pfam00288 |
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ... |
82-143 |
1.54e-13 |
|
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.
Pssm-ID: 395225 [Multi-domain] Cd Length: 64 Bit Score: 64.49 E-value: 1.54e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 973245899 82 DIEMRSDIPMARGLGSSASALVAALYIANHFGALQLSK--YELLQLATEFEGHPDNVAPTIYGG 143
Cdd:pfam00288 1 DIEIESNIPLGAGLGSSAALAVALLLALNELFGLPLAKlaLEAEELAGGGRGGGMDVAASLYGG 64
|
|
| ispE |
TIGR00154 |
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ... |
27-275 |
2.56e-10 |
|
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Pssm-ID: 188029 [Multi-domain] Cd Length: 294 Bit Score: 60.22 E-value: 2.56e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 27 LNKFLVITAKRND-----QQRWRFKHLG----------------PNVDELPNDEtHYIYQIAQRVASRYDITLPC---LD 82
Cdd:TIGR00154 11 INLFLYILGKRPDgyhelQMLMQFIDLGdkiiisvrsdddirllKGDFDVPLEE-NLAYRAAQLLKNFANSKIKSldgVN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 83 IEMRSDIPMARGLGSSASALVAALYIANHFGALQLSKYELLQLATEFEGhpdNVAPTIYGG--LVVGYfdpktGDTDISY 160
Cdd:TIGR00154 90 IEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGA---DVPFFVSGGtaFATGR-----GEIITPF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 161 IDVPKVDVVITVPSYELKTTEARQA--LPATmTHQQAVQSSAISNTMISVLIQHNYtlagkmmeQDQLHEPYRQSLiPEF 238
Cdd:TIGR00154 162 EDPPEKWVVIAKPHVSVSTPVVYQAykLPRN-TPKRAKEWLKKISLECLQLLDSNG--------LNDLEKVALKRH-TEV 231
|
250 260 270
....*....|....*....|....*....|....*..
gi 973245899 239 AEIKQLAKSLHAYATVISGAGPTVLTLVHQAHSGELV 275
Cdd:TIGR00154 232 AQALNWLLEYGLAPERMSGSGPCVFALFDMESEAEQV 268
|
|
| IspE |
COG1947 |
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ... |
33-282 |
4.66e-09 |
|
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis
Pssm-ID: 441550 [Multi-domain] Cd Length: 281 Bit Score: 56.28 E-value: 4.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 33 ITAKRNDQQRWRFKHLGPNVdelPNDETHYIYQIAQRVASRYDITLPcLDIEMRSDIPMARGL--GSS--ASALVAalyi 108
Cdd:COG1947 40 LTIEPADDGSISLTGPGAGV---PTDEDNLVYRAARLLQEATGIPPG-VDIHLEKRIPVGAGLggGSSdaAATLRA---- 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 109 ANHFGALQLSKYELLQLATE-------FeghpdnvaptIYGG--LVVGyfdpkTGD--TDISyiDVPKVDVVITVPSYEL 177
Cdd:COG1947 112 LNRLWGLGLSREELAELAAKlgadvpfF----------LYGGtaLAEG-----RGEklTPLP--PLPELWLVLVKPGVGV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 178 KTTEARQALpatmtHQQAVQSSAISNTMISVLIQHNYTLAgkmmeqDQLH---EPYRQSLIPEFAEIKQLAKSLHAYATV 254
Cdd:COG1947 175 STAEVYRAL-----DLTRDTPPPDIDALLAALAAGDAALA------ALLRndlEPVAFKLYPEIAEVLEALLEAGALAAR 243
|
250 260
....*....|....*....|....*....
gi 973245899 255 ISGAGPTVLTLV-HQAHSGELVRTLRSHF 282
Cdd:COG1947 244 MSGSGSTVFGLFeDEEAAEAAAAALPARG 272
|
|
| mevalon_kin |
TIGR00549 |
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ... |
19-259 |
5.50e-09 |
|
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]
Pssm-ID: 273130 [Multi-domain] Cd Length: 273 Bit Score: 56.15 E-value: 5.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 19 GFDSIGMALNKFLVITAKRNDQQRWRFKHLGPNVDELPNDETHYIYQIAQRVASRY-DITLPCLDIEMRSDIPMARGLGS 97
Cdd:TIGR00549 16 GEPAIAAPIPLRTTVTVIESSDGSFIESDLGRGSLDDAPDELDGLKYVLAEFLSRFsELNPPPLEITIESEIPPGRGLGS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 98 SASALVA-ALYIANHFGAlQLSKYELLQLATEFE----GHPDNVAPTI--YGGLVvgYFDPKTGDTDIsyIDVPKVDVVI 170
Cdd:TIGR00549 96 SAAVAVAlIRALADYFGS-ELSKEELAELANEAEkiahGKPSGIDTATstSGGPV--YFEKGEGEFTK--LISLDGYFVI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 171 TVPSYELKTTEA-------RQALP-ATMTHQQAVQSsaISNTMISVLIQHNYTLAGKMME--QDQLHepyrqSL---IPE 237
Cdd:TIGR00549 171 ADTGVSGSTKEAvarvrqlLERFPeLIDSIMDAIGE--LTLEAKAALQDGDVESLGELMNinQGLLK-----ALgvsHPK 243
|
250 260
....*....|....*....|..
gi 973245899 238 FAEIKQLAKSLHAYATVISGAG 259
Cdd:TIGR00549 244 LDQLVEIARKAGALGAKLTGAG 265
|
|
| COG2605 |
COG2605 |
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ... |
23-130 |
1.22e-07 |
|
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];
Pssm-ID: 442017 [Multi-domain] Cd Length: 328 Bit Score: 52.10 E-value: 1.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 23 IGMALNKFLVITAKRNDQQRWRFKHLGPNVDELPNDETHYIYQIAQRVASRYDITLPcLDIEMRSDIPMARGLGSSASAL 102
Cdd:COG2605 30 LNAAIDKYAYVTLEPRFDGKIRLSSSDTERVETVDEDDDIPHPVIREALKLFGIGDG-LEITTDSDAPAGSGLGSSSALT 108
|
90 100
....*....|....*....|....*...
gi 973245899 103 VAALYIANHFGALQLSKYELLQLATEFE 130
Cdd:COG2605 109 VALLNALHALLGLPLSPYDLARLAYEIE 136
|
|
| GalK |
COG0153 |
Galactokinase [Carbohydrate transport and metabolism]; |
25-126 |
3.30e-07 |
|
Galactokinase [Carbohydrate transport and metabolism];
Pssm-ID: 439923 [Multi-domain] Cd Length: 380 Bit Score: 50.93 E-value: 3.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 25 MALNKFLVITAKRNDQQRWRFKHLGPN------VDELPNDETH----YIYQIAQRVASRyDITLPCLDIEMRSDIPMARG 94
Cdd:COG0153 44 AAIDRGTYAAARPRDDRKVRVYSADFDeevefdLDDLEPGEEDgwanYVRGVAWALQER-GYKLGGFDLVIDGDVPLGAG 122
|
90 100 110
....*....|....*....|....*....|..
gi 973245899 95 LGSSASALVAALYIANHFGALQLSKYELLQLA 126
Cdd:COG0153 123 LSSSAALEVAVALALNDLFGLGLDPVELAKIG 154
|
|
| GHMP_kinases_C |
pfam08544 |
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ... |
205-284 |
2.74e-05 |
|
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.
Pssm-ID: 430063 [Multi-domain] Cd Length: 85 Bit Score: 42.07 E-value: 2.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 205 MISVLIQHNYTLAGKMMEQDQ-LHEPYRQ--SLIPEFAEIKQLAKSLHaYATVISGA--GPTVLTLV-HQAHSGELVRTL 278
Cdd:pfam08544 1 LLEALLRGDLEELGKLLTESAeSLEPLLVvgILPPELDELLEALLELG-LGAKLSGSggGPTVFALFkDEDDAEEVARAL 79
|
....*.
gi 973245899 279 RSHFPA 284
Cdd:pfam08544 80 REAGKK 85
|
|
| PRK03817 |
PRK03817 |
galactokinase; Provisional |
25-130 |
3.96e-05 |
|
galactokinase; Provisional
Pssm-ID: 235163 [Multi-domain] Cd Length: 351 Bit Score: 44.60 E-value: 3.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973245899 25 MALNKFLVITAKRNDQQRWRFKHLGP----NVDELP--NDETHYIYQIAQRVASR-YDITLpcLDIEMRSDIPMARGLGS 97
Cdd:PRK03817 26 FAINLYTFLEIEKSEKFIFYSENFNEektfELDKLEklNSWADYIKGVIWVLEKRgYEVGG--VKGKVSSNLPIGAGLSS 103
|
90 100 110
....*....|....*....|....*....|...
gi 973245899 98 SASALVAALYIANHFGALQLSKYELLQLATEFE 130
Cdd:PRK03817 104 SASLEVAVAYALNEAYNLNLSKLELALLAREAE 136
|
|
| PRK03926 |
PRK03926 |
mevalonate kinase; Provisional |
82-130 |
1.61e-03 |
|
mevalonate kinase; Provisional
Pssm-ID: 179677 [Multi-domain] Cd Length: 302 Bit Score: 39.65 E-value: 1.61e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 973245899 82 DIEMRSDIPMARGLGSSASALVAALYIANHFGALQLSKYELLQLATEFE 130
Cdd:PRK03926 77 TVSITSQIPVGSGLGSSAAVTVATIGALNRLLGLGLSLEEIAKLGHKVE 125
|
|
| |
