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Conserved domains on  [gi|981346045|ref|WP_059561758|]
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universal stress protein [Burkholderia stagnalis]

Protein Classification

universal stress protein( domain architecture ID 10001747)

universal stress protein (USP) enhances the rate of cell survival during prolonged exposure to stress agents

CATH:  3.40.50.620
Gene Ontology:  GO:0042802
PubMed:  23745136|9405142|12732303
SCOP:  8083864

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
153-275 5.04e-12

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


:

Pssm-ID: 440354  Cd Length: 136  Bit Score: 61.86  E-value: 5.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981346045 153 ENVLIAWDGGREAARAVADALPLLKR--ARFVTVETVERHRSDPDKTPAGVD------------VAAYLERHGIRASfaT 218
Cdd:COG0589    3 KRILVPTDGSEEAERALEYAAELAKAlgAELHLLHVVDPPPSAAAGPEELEEelreeaeealeeAAERLEEAGVEVE--T 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 981346045 219 TPREGDIntGETLLNRTSDLHSDLLVMGAYSHARMRERVLGGATRTILETMTVPVLM 275
Cdd:COG0589   81 VVREGDP--AEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
3-112 1.03e-07

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


:

Pssm-ID: 440354  Cd Length: 136  Bit Score: 49.92  E-value: 1.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981346045   3 YKTLLVHLDDSPRCATRVALALDLAQRCNAHLIGLYVVcqdlfePLRRRDEPLELAVYERLCESRRKQAEiAFLDAAQRA 82
Cdd:COG0589    2 YKRILVPTDGSEEAERALEYAAELAKALGAELHLLHVV------DPPPSAAAGPEELEEELREEAEEALE-EAAERLEEA 74

                         90       100       110
                 ....*....|....*....|....*....|..
gi 981346045  83 GRSVEWRAPAGPATET--ATLHARHADLLVLG 112
Cdd:COG0589   75 GVEVETVVREGDPAEAilEAAEELDADLIVMG 106
 
Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
153-275 5.04e-12

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 61.86  E-value: 5.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981346045 153 ENVLIAWDGGREAARAVADALPLLKR--ARFVTVETVERHRSDPDKTPAGVD------------VAAYLERHGIRASfaT 218
Cdd:COG0589    3 KRILVPTDGSEEAERALEYAAELAKAlgAELHLLHVVDPPPSAAAGPEELEEelreeaeealeeAAERLEEAGVEVE--T 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 981346045 219 TPREGDIntGETLLNRTSDLHSDLLVMGAYSHARMRERVLGGATRTILETMTVPVLM 275
Cdd:COG0589   81 VVREGDP--AEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 154-275 9.01e-10

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 55.82  E-value: 9.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981346045 154 NVLIAWDGGREAARAVADALPLLKRAR----FVTVETVERHRSDPDKTPAGVD-----VAAYLERHGIRASFATTPREGD 224
Cdd:cd00293    1 KILVAVDGSEESERALEWALELAKRPGaeltLLHVVDPPPSSSLSGGLEELADelkeeAEELLEEAKKLAEEAGVEVETI 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 981346045 225 INTG---ETLLNRTSDLHSDLLVMGAYSHARMRERVLGGATRTILETMTVPVLM 275
Cdd:cd00293   81 VVEGdpaEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLV 134
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
3-112 1.03e-07

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 49.92  E-value: 1.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981346045   3 YKTLLVHLDDSPRCATRVALALDLAQRCNAHLIGLYVVcqdlfePLRRRDEPLELAVYERLCESRRKQAEiAFLDAAQRA 82
Cdd:COG0589    2 YKRILVPTDGSEEAERALEYAAELAKALGAELHLLHVV------DPPPSAAAGPEELEEELREEAEEALE-EAAERLEEA 74

                         90       100       110
                 ....*....|....*....|....*....|..
gi 981346045  83 GRSVEWRAPAGPATET--ATLHARHADLLVLG 112
Cdd:COG0589   75 GVEVETVVREGDPAEAilEAAEELDADLIVMG 106
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 6-143 3.66e-07

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 48.17  E-value: 3.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981346045    6 LLVHLDDSPRCATRVALALDLAQRCNAHLIGLYVVCQDLFEPlrrRDEPLELAVYERLCESRRKQAEIAFLDAAQRAGRS 85
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGA---ASLADESAEEEELELELAEAEALAAAAAAEAGGVK 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 981346045   86 VEWRAPAGPATETATLHAR--HADLLVLGQTDPHDRTTYIAPHFVEDVVTGCGRPAIIVP 143
Cdd:pfam00582  78 VEVVVVVGDPAEEILEVAEeeDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 5-142 3.82e-03

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 36.94  E-value: 3.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981346045   5 TLLVHLDDSPRCATRVALALDLAQRCNAHLIGLYVVcqdlfEPLRRRDEPLELAVYERLCESRRKQAEIAFLDAAQRAGR 84
Cdd:cd00293    1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVV-----DPPPSSSLSGGLEELADELKEEAEELLEEAKKLAEEAGV 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 981346045  85 SVEWRAPAGPATETATLHARH--ADLLVLGQTDPHDRTTYIAPHFVEDVVTGCGRPAIIV 142
Cdd:cd00293   76 EVETIVVEGDPAEAILEEAKElgADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLVV 135
 
Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
153-275 5.04e-12

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 61.86  E-value: 5.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981346045 153 ENVLIAWDGGREAARAVADALPLLKR--ARFVTVETVERHRSDPDKTPAGVD------------VAAYLERHGIRASfaT 218
Cdd:COG0589    3 KRILVPTDGSEEAERALEYAAELAKAlgAELHLLHVVDPPPSAAAGPEELEEelreeaeealeeAAERLEEAGVEVE--T 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 981346045 219 TPREGDIntGETLLNRTSDLHSDLLVMGAYSHARMRERVLGGATRTILETMTVPVLM 275
Cdd:COG0589   81 VVREGDP--AEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 154-275 9.01e-10

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 55.82  E-value: 9.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981346045 154 NVLIAWDGGREAARAVADALPLLKRAR----FVTVETVERHRSDPDKTPAGVD-----VAAYLERHGIRASFATTPREGD 224
Cdd:cd00293    1 KILVAVDGSEESERALEWALELAKRPGaeltLLHVVDPPPSSSLSGGLEELADelkeeAEELLEEAKKLAEEAGVEVETI 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 981346045 225 INTG---ETLLNRTSDLHSDLLVMGAYSHARMRERVLGGATRTILETMTVPVLM 275
Cdd:cd00293   81 VVEGdpaEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLV 134
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
3-112 1.03e-07

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 49.92  E-value: 1.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981346045   3 YKTLLVHLDDSPRCATRVALALDLAQRCNAHLIGLYVVcqdlfePLRRRDEPLELAVYERLCESRRKQAEiAFLDAAQRA 82
Cdd:COG0589    2 YKRILVPTDGSEEAERALEYAAELAKALGAELHLLHVV------DPPPSAAAGPEELEEELREEAEEALE-EAAERLEEA 74

                         90       100       110
                 ....*....|....*....|....*....|..
gi 981346045  83 GRSVEWRAPAGPATET--ATLHARHADLLVLG 112
Cdd:COG0589   75 GVEVETVVREGDPAEAilEAAEELDADLIVMG 106
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 6-143 3.66e-07

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 48.17  E-value: 3.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981346045    6 LLVHLDDSPRCATRVALALDLAQRCNAHLIGLYVVCQDLFEPlrrRDEPLELAVYERLCESRRKQAEIAFLDAAQRAGRS 85
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGA---ASLADESAEEEELELELAEAEALAAAAAAEAGGVK 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 981346045   86 VEWRAPAGPATETATLHAR--HADLLVLGQTDPHDRTTYIAPHFVEDVVTGCGRPAIIVP 143
Cdd:pfam00582  78 VEVVVVVGDPAEEILEVAEeeDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 5-142 3.82e-03

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 36.94  E-value: 3.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981346045   5 TLLVHLDDSPRCATRVALALDLAQRCNAHLIGLYVVcqdlfEPLRRRDEPLELAVYERLCESRRKQAEIAFLDAAQRAGR 84
Cdd:cd00293    1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVV-----DPPPSSSLSGGLEELADELKEEAEELLEEAKKLAEEAGV 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 981346045  85 SVEWRAPAGPATETATLHARH--ADLLVLGQTDPHDRTTYIAPHFVEDVVTGCGRPAIIV 142
Cdd:cd00293   76 EVETIVVEGDPAEAILEEAKElgADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLVV 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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