|
Name |
Accession |
Description |
Interval |
E-value |
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
22-455 |
3.03e-157 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 452.48 E-value: 3.03e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 22 RIGYGFGDMSYNIVFQFVNAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWVAFPF 101
Cdd:TIGR00792 1 KLSYGFGDFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRTRTRWGKFRPWLLIGAIPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 102 ALFTFLCFTTPHFGETGNMVYAYITYILLGMSFSMQTIPVNSLTGRMTNSVEERTVLTTTRMILVYIGILLSISCATPLA 181
Cdd:TIGR00792 81 SIVLVLLFTTPDFSGTGKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRRFGATLGGLLVAVIVLPLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 182 TAIGGENQAFGFQMTALIYAAVSIVLNLFSFFTVRERIQ---PKKRKKQGIKKTLSVLFRNKPLLILISSFLAFAIGFNI 258
Cdd:TIGR00792 161 SYFGGGDDKFGWFMFALVLALIGVVSLIICFFGTKERYSeipKNIEKKLSLKQIFKALFKNDQLLILCLAYLFYNLAFNI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 259 KLSTMVYYFTYNVNH-KEFVFLGTVLfFGAALISNLFIPFFSEKWGRKQVMIITAGLSLISYAGLHFTPYSSItLIFIWL 337
Cdd:TIGR00792 241 KNGVQVYYFTYVLGDpELFSYMGSIA-IVAGLIGVLLFPRLVKKFGRKILFAGGILLMVLGYLIFFFAGSNLP-LILVLI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 338 FVSGFFTTPLNTLAWGMVADCVDYAEWKTGVRADGVVISSMSFINKLGVALAGSFSAIYLGIAGYVANADQTVTSLNAIK 417
Cdd:TIGR00792 319 ILAGFGQNIVTGLVWALVADTVDYGEWKTGIRAEGLVYSVRTFVRKLGQALAGFFVGLILGIIGYVANAAQSPITLNGIK 398
|
410 420 430
....*....|....*....|....*....|....*....
gi 982922748 418 NMNALIPGLFILLSIILIA-FYPLTEKRYKQIISELEKR 455
Cdd:TIGR00792 399 ILMFAVPALFLLLAAIIIGrFYKLTEKKHAEIVEELEQR 437
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
22-442 |
4.85e-122 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 362.31 E-value: 4.85e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 22 RIGYGFGDMSYNIVFQFVNAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWVAFPF 101
Cdd:cd17332 1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAIPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 102 ALFTFLCFTTPHFGETGNMVYAYITYILLGMSFSMQTIPVNSLTGRMTNSVEERTVLTTTRMILVYIGILLSISCATPLA 181
Cdd:cd17332 81 ALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 182 TAIGGENQAFGFQMTALIYAAVSIVLNLFSFFTVRERIQPKKR--KKQGIKKTLSVLFRNKPLLILISSFLAFAIGFNIK 259
Cdd:cd17332 161 AYFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEekSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 260 LSTMVYYFTYN-VNHKEFVFLGtVLFFGAALISNLFIPFFSEKWGRKQVMIITAGLSLISYAGLHFTPYSSITLIFIWLF 338
Cdd:cd17332 241 NTVLVYYFKYVlGGRAELVLLL-LLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 339 VSGFFTTPLNTLAWGMVADCVDYAEWKTGVRADGVVISSMSFINKLGVALAGSFSAIYLGIAGYVAN-ADQTVTSLNAIK 417
Cdd:cd17332 320 LAGIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVANaAAQSASALNGIR 399
|
410 420
....*....|....*....|....*
gi 982922748 418 NMNALIPGLFILLSIILIAFYPLTE 442
Cdd:cd17332 400 LLIAVLPAVLLLLALILMSFYPLDK 424
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
12-458 |
1.55e-119 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 356.52 E-value: 1.55e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 12 AKHHGLSWFERIGYGFGDMSYNIVFQFVNAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKAR 91
Cdd:COG2211 2 AAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 92 PYLLWVAFPFALFTFLCFTTPHFGETGNMVYAYITYILLGMSFSMQTIPVNSLTGRMTNSVEERTVLTTTRMILVYIGIL 171
Cdd:COG2211 82 PWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 172 LSISCATPLATAIGGeNQAFGFQMTALIYAAVSIVLNLFSFFTVRERIQPkKRKKQGIKKTLSVLFRNKPLLILISSFLA 251
Cdd:COG2211 162 LASVLPPPLVAAFGG-DAALGYRLTALIFAVLGLLAFLLTFFGTKERPVP-EEEKVSLKESLKALLKNRPFLLLLLAYLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 252 FAIGFNIKLSTMVYYFTYNVNHKE-FVFLGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAGLSLISYAGLHFTPYSSI 330
Cdd:COG2211 240 FFLALALVAALLLYYFKYVLGLSAaLVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 331 TLIFIWLFVSGFFTTPLNTLAWGMVADCVDYAEWKTGVRADGVVISSMSFINKLGVALAGSFSAIYLGIAGYVANADQTV 410
Cdd:COG2211 320 WLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAAQSP 399
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 982922748 411 TSLNAIKNMNALIPGLFILLSIILIAFYPLTEKRYKQIISELEKRSAK 458
Cdd:COG2211 400 SALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAARRAA 447
|
|
| PRK09848 |
PRK09848 |
glucuronide transporter; Provisional |
17-457 |
8.93e-88 |
|
glucuronide transporter; Provisional
Pssm-ID: 182109 [Multi-domain] Cd Length: 448 Bit Score: 275.13 E-value: 8.93e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 17 LSWFERIGYGFGDMSYNIVFQFVNAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLW 96
Cdd:PRK09848 5 LSWRTIVGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRVFDAFADVFAGRVVDSVNTRWGKFRPFLLF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 97 VAFPFALFTFLCFTTP-HFGETGNMVYAYITYILLGMSFSMQTIPVNSLTGRMTNSVEERTVLTTTRMI-----LVYIGI 170
Cdd:PRK09848 85 GTAPLMIFSVLVFWVPtDWSHSSKVVYAYLTYMGLGLCYSLVNIPYGSLATAMTQQPQSRARLGAARGIaasltFVCLAF 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 171 LLSiscatPLATAIGGENQAFGFQMTALIYAAVSIVLNLFSFFTVRERIQpKKRKKQGIKKTLSVLFRNKPLLILISSFL 250
Cdd:PRK09848 165 LIG-----PSIKNSSPEEMVSVYHFWTIVLAIAGMVLYFICFKSTRENVV-RIVAQPSLKISLQTLKRNRPLFMLCIGAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 251 AFAIGFNIKLSTMVYYFTYNVNH-KEFVFLGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAGLSLISYAGLHFTPYSS 329
Cdd:PRK09848 239 CVLISTFAVSASSLFYVRYVLNDtGLFTVLVLVQNLVGTVASAPLVPGMVARIGKKNTFLIGALLGTCGYLLFFWVSVWS 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 330 ITLIFIWLFVSGFFTTPLNTLAWGMVADCVDYAEWKTGVRADGVVISSMSFINKLGVALAGSFSAIYLGIAGYVANADQT 409
Cdd:PRK09848 319 LPVALVALAIASIGQGVTMTVMWALEADTVEYGEYLTGVRIEGLTYSLFSFTRKCGQAIGGSIPAFILGLSGYIANQVQT 398
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 982922748 410 VTSLNAIKNMNALIPGLFILLSIILIAFYPLTEKRYKQIISELEKRSA 457
Cdd:PRK09848 399 PEVIMGIRTSIALVPCGFMLLAFVIIWFYPLTDKKFKEIVVEIDNRKK 446
|
|
| PRK09669 |
PRK09669 |
putative symporter YagG; Provisional |
21-452 |
1.52e-77 |
|
putative symporter YagG; Provisional
Pssm-ID: 236610 Cd Length: 444 Bit Score: 248.49 E-value: 1.52e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 21 ERIGYGFGDMSYNIVFQFVNAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWVAFP 100
Cdd:PRK09669 10 DKIGYGLGDTACNLVWQTVMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTRTRHGQFRPYLLWFAIP 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 101 FALFTFLCFTTPHFGETGNMVYAYITYILLGMSFSMQTIPVNSLTGRMTNSVEERTVLTTTRMILVYIGILLSISCATPL 180
Cdd:PRK09669 90 FGVVCLLTFYTPDFGATGKIIYACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIGGLIVSVIALPL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 181 ATAIGGENQAFGFQMTALIYAAVSIVLNLFSFFTVRERIQPKKRKKQGIKKTLSVLFRNKPLLILISSFLAFAIGFNIKL 260
Cdd:PRK09669 170 VDILGKGDEQKGYFYAMMVMGLLGVVLFFCCFFMTKERYTPEVDNSSSVWKDLKLLLGNSQWRIMFIFNVVLLTAVVTRG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 261 STMVYYFTYNVNHKEFVFLGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAGLSLISYAGLHFTPYSSITLIFIWLFVS 340
Cdd:PRK09669 250 GATLYYVNYVLLRPDLATLFLVTGMIAGLFGALLSERLLGKFDRVRAFKWTIVAFVILSALIFFIPPSNVWLIFALNILF 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 341 GFFTTPLNTLAWGMVADCVDYAEWKTGVRADGVVISSMSFINKLGVALAGSFSAIYLGIAGYVANAD-QTVTSLNAIKNM 419
Cdd:PRK09669 330 NFIQNLTTPLQWSMFSDVVDYEEKRSGRRLDGLVFSTNLFAIKLGLAIGGAVVGWILAWVDYVGGAAvQSASVLTTINLL 409
|
410 420 430
....*....|....*....|....*....|...
gi 982922748 420 NALIPGLFILLSIILIAFYPLTEKRYKQIISEL 452
Cdd:PRK09669 410 FTVIPGVLFAGMAIILNFYKLNDARVEAIAQEL 442
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
24-442 |
1.10e-70 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 230.27 E-value: 1.10e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 24 GYGFGDMSYNIVFQFVNAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWVAFPFAL 103
Cdd:pfam13347 1 GYGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 104 FTFLCFTTPHFGETGNMVYAYITYILLGMSFSMQTIPVNSLTGRMTNSVEERTVLTTTRMILVYIGILLSISCATPLATA 183
Cdd:pfam13347 81 SFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 184 IGG-ENQAFGFQMTALIYAAVSIVLNLFSFFTVRERIQ------PKKRKKQGIKKTLSVLFRNKPLLILISSFLAFAIGF 256
Cdd:pfam13347 161 LGGtGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSmrskedTGQKEAGSLLDMLKEVFRNRAFLILLASFLLAALAM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 257 NIKLSTMVYYFTYNVNHKEFVFLGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAGLSLISYAGLHFTPYSSITLIFIW 336
Cdd:pfam13347 241 GVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGPNNTLLFLVL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 337 LFVSGFFTTPLNTLAWGMVADCVDYAEWKTGVRADGVVISSMSFINKLGVALAGSFSAIYLGIAGYVA-NADQTVTSLNA 415
Cdd:pfam13347 321 YIIIGFGYGSSFFLPWSMLADVVDYGELRTGKRREGTFFAMWSFISKLATGVGLGVSGLLLSAFGYNAgDSVQSPQAVTA 400
|
410 420
....*....|....*....|....*..
gi 982922748 416 IKNMNALIPGLFILLSIILIAFYPLTE 442
Cdd:pfam13347 401 IRLLYAVLPAVLFLVALLLLYFYPLDR 427
|
|
| PRK11462 |
PRK11462 |
putative transporter; Provisional |
13-454 |
1.31e-68 |
|
putative transporter; Provisional
Pssm-ID: 183145 Cd Length: 460 Bit Score: 225.59 E-value: 1.31e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 13 KHHGLSWFERIGYGFGDMSYNIVFQFVNAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARP 92
Cdd:PRK11462 2 KSEVLSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFRP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 93 YLLWVAFPFALFTFLCFTTPHFGETGNMVYAYITYILLGMSFSMQTIPVNSLTGRMTNSVEERTVLTTTRMILVYIGILL 172
Cdd:PRK11462 82 WVLFGALPFGIVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGML 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 173 SISCATPLATAIGGENQAFGFQMTALIYAAVSIVLNLFSFFTVRERIQpKKRKKQGIKKTLSVLFRNKPLLILISSFLAF 252
Cdd:PRK11462 162 STVLMMPLVNLIGGDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKERVE-APPTTTSMREDLRDIWQNDQWRIVGLLTIFN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 253 AIGFNIKLSTMVYYFTYNVNHKE-FVFLGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAGLSLISYAgLHFTPYSSIT 331
Cdd:PRK11462 241 ILAVCVRGGAMMYYVTWILGTPEvFVAFLTTYCVGNLIGSALAKPLTDWKCKVTIFWWTNALLAVISLA-MFFVPMQASI 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 332 LIFIWLFVSGFFTTPLNTLAWGMVADCVDYAEWKTGVRADGVVISSMSFINKLGVALAGSFSAIYLGIAGYVANAD-QTV 410
Cdd:PRK11462 320 TMFVFIFVIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKaQNS 399
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 982922748 411 TSLNAIKNMNALIPGLFILLSIILIA-FYPLTEKRYKQIISELEK 454
Cdd:PRK11462 400 ATISIIIALFTIVPAICYLLSAIIAKrYYSLTTHNLKTVMEQLAQ 444
|
|
| PRK10429 |
PRK10429 |
melibiose:sodium transporter MelB; |
17-424 |
1.64e-67 |
|
melibiose:sodium transporter MelB;
Pssm-ID: 182453 Cd Length: 473 Bit Score: 223.05 E-value: 1.64e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 17 LSWFERIGYGFGDMSYNIVFQFVNAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLW 96
Cdd:PRK10429 3 ISMTTKLSYGFGAFGKDFAIGIVYMYLMYYYTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVNNTRSRWGKFKPWILI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 97 VAFPFALFTFLCFTTPHFGETGNMVYAYITYILLGMSFSMQTIPVNSLTGRMTNSVEERTVLTTTRMILVYIGILLSISC 176
Cdd:PRK10429 83 GTLANSVVLFLLFSAHLFEGTAQYVFVCVTYILWGMTYTIMDIPFWSLVPTLTLDKREREQLVPYPRFFASLAGFVTAGF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 177 ATPLATAIGGENQAFGFQMTALIYAAVSIVLNLFSFFTVRER-----IQPKKRKKQGIKKTLSVLFRNKPLLILISSFLA 251
Cdd:PRK10429 163 TLPFVNYVGGGDRGFGFQMFTLVLIAFFIVSTIITLRNVHEVyssdnQVSAEGSHLTLKDIVALIYKNDQLSCLLGMALA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 252 FAIGFNIKLSTMVYYFTYNVNHKEFVFLGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAGLSLISYAGL---HFTPYS 328
Cdd:PRK10429 243 YNIASNIINGFAIYYFTYVIGDADLFPYYLSYAGAANLVTLILFPRLVKSLSRRILWAGASIFPVLSCGVLllmGLAAPH 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 329 SITLIFIWLFVSGFFTTPLNTLAWGMVADCVDYAEWKTGVRADGVVISSMSFINKLGVALAGSFSAIYLGIAGYVANADQ 408
Cdd:PRK10429 323 NALLIVIAGILLNIGTALFWVLQVIMVADTVDYGEYKLGIRCESIAYSVQTMVVKGGSAFAAFFIGVVLGLIGYVPNVEQ 402
|
410
....*....|....*.
gi 982922748 409 TVTSLNAIKNMNALIP 424
Cdd:PRK10429 403 SAQTLLGMQFIMIGLP 418
|
|
| MFS_MFSD2B |
cd17452 |
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily ... |
22-442 |
1.09e-16 |
|
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily domain-containing protein 2B (MFSD2B) is closely related to MFSD2A, and their conserved genomic structure suggests that they are derived from the duplication of an ancestral gene. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer identified MFSD2B as a potential risk or protect factor in the prognosis of lung adenocarcinoma. MFSD2B belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341010 Cd Length: 416 Bit Score: 81.79 E-value: 1.09e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 22 RIGYGFGDMSYNIVFQFVNAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTN-TRWGKARPYLLWVAFP 100
Cdd:cd17452 1 KLCYAIGGAPNQVAGSATAFFLQIYLLDIAQITPFQASLVLFVGKAWGAATDPVVGFFISKSKwTKIGRLMPWMLGCTPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 101 FALFTFLCFTTPHFgETGNMVYAYITYILLGMSFSMQTIPVNSLTGRMTNSVEERTVLTTTRMILVYIGILlsiscatpL 180
Cdd:cd17452 81 IVVSYFFLWFVPPF-TTGRFLWYLTFYCLFQALATCFHVPYSALTMFLSTDQRERDSATAYRMTVEVLGTL--------V 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 181 ATAIGGENQAFGFQMTALIYAAVSIVLNLFSFFTVRERIQPKKRKKQGI---KKTLSVLFRNKPLLILISSFLAFAIGFN 257
Cdd:cd17452 152 GAAVQGQIVASAYMIAAGVIGGLYLLCISVLFLGVKERDDPYAPKSGKAipfFKGLSLTMRHGPYLKLTASFLFISAAVQ 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 258 IKLSTMVYYFTYNVNHKEFVFLGTVLFFGAALISNLFIPFFSEKWGRKQVMIitaGLSLISYAGLHFTPYSSITLIFIWL 337
Cdd:cd17452 232 LEQSNFVLFCTHAVDLHDHFQNLVLTILVSAVVSIPFWQWFLQRFGKKAAAC---GISWMIPFAIMLVTIPNLIVAYVVA 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 338 FVSGFFTTPLNTLAWGMVADCVDYAEWKT--GVRADGVVISSMSFINKLGVALAGSFSAIYLGIAGYVANA-DQTVTSLN 414
Cdd:cd17452 309 FVSGLSIAASLLLPWSMLPDVVDDFRLQNphGKGLETIFYSSYVFFTKLSAGIALGISTLSLEFAGYETGAcKQPESVVL 388
|
410 420
....*....|....*....|....*...
gi 982922748 415 AIKNMNALIPGLFILLSIILIAFYPLTE 442
Cdd:cd17452 389 TLKLLIGAAPTCMILIGLCILMFYPITE 416
|
|
| MFS_MFSD2 |
cd17392 |
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator ... |
25-406 |
6.49e-13 |
|
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator superfamily domain-containing protein 2 (MFSD2) subfamily is composed of two vertebrate members, MFSD2A amd MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD2 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340950 Cd Length: 446 Bit Score: 70.19 E-value: 6.49e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 25 YGFGDMSYNIVFQFVNAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTN-TRWGKARPYLLWVAFPFAL 103
Cdd:cd17392 4 YAIGGAPYQMTSSATGFFLQIFLLDVAQMGAFSVSLILFVGRVWDAVTDPLVGYFISRSQrTGIGRLMPWIVFSTPLIIL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 104 FTFLCFTTPHFgETGNMVYAYITYILLGMSFSMQTIPVNSLTGRMTNSVEERTVLTTTRMILVYIGILL----------- 172
Cdd:cd17392 84 AYFFLWFLPPF-TSLSGLWYLTFYCLFETFMTCFHVPYSALTMFLGGCQRERDSATAYRMTVEVFGTLMgatiqgqivgv 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 173 ---------SISCATPLATAIGGENQAFGFQMTALIYAAVSIVLNLFSFFTVRERIQPKKRKK---QGIKKTLSVLFRNK 240
Cdd:cd17392 163 ahrprrqdcTATPGTSDHPVTVLPNTRRAYLIAALVVVVLYFVCCSILFLGVKEQPDPLSPASgpgLSYLAGLKLVTGHP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 241 PLLILISSFLAFAIGFNIKLSTMVYYFTYNVN-HKEFVFLGTVLFFGAALISNLFIPFFSEKWGRKQVMIitaGLS-LIS 318
Cdd:cd17392 243 PYLKLVIGFLFSSLAFQMEQGNFVLFCTHAAGlGDHFQHLVLAILVSATLSIPLWQWVLQRRGKKTTSFI---GISaMVP 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 319 YAGLHFTPYSSITLIFIWLFVSGFFTTPLNTLAWGMVADCVDYAEWK--TGVRADGVVISSMSFINKLGVALAGSFSAIY 396
Cdd:cd17392 320 FLILLALVPSNLPVAYVVAVVSGVSLAALFLLPWSMLPDVVDDFQLKnpHCPGLEPIFYSCYVFFTKLGGGLSLGISTLS 399
|
410
....*....|
gi 982922748 397 LGIAGYVANA 406
Cdd:cd17392 400 LHFSGYKAGA 409
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
56-389 |
4.08e-11 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 64.22 E-value: 4.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 56 AVIATLFLVVRvldAIFDPIMGLILDktntRWGKaRPYLLWVAFPFALFTFLCFTTPHFGEtgnmvyAYITYILLGMSFS 135
Cdd:COG2814 48 GLVVTAYLLGA---ALGAPLAGRLAD----RFGR-RRVLLLGLLLFALGSLLCALAPSLWL------LLAARFLQGLGAG 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 136 MQTIPVNSLTGRMTnSVEERTVLtttrMILVYIGILLSISCATPLATAIGgenQAFGFQMTALIYAAVSIVLNLFSFFTV 215
Cdd:COG2814 114 ALFPAALALIADLV-PPERRGRA----LGLLGAGLGLGPALGPLLGGLLA---DLFGWRWVFLVNAVLALLALLLLLRLL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 216 RERIQPKKRKKQGikkTLSVLFRNKPLLILISSFLAFAIGFNIKLSTMVYYFTYNVNHKEFVF-LGTVLFFGAALISNLF 294
Cdd:COG2814 186 PESRPAARARLRG---SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAgLLLALFGLGGVLGALL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 295 IPFFSEKWGRKQVMIITAGLSLISYAGLHFTPysSITLIFIWLFVSGFFTTPLNTLAWGMVADCVdyaewktGVRADGVV 374
Cdd:COG2814 263 AGRLADRFGRRRLLLIGLLLLALGLLLLALAG--SLWLLLLALFLLGFGFGLLFPLLQALVAELA-------PPEARGRA 333
|
330
....*....|....*
gi 982922748 375 ISSMSFINKLGVALA 389
Cdd:COG2814 334 SGLYNSAFFLGGPLA 348
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
39-401 |
2.53e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 62.06 E-value: 2.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 39 VNAYLLFYYTDVGgIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNtrwgkARPYLLWVAFPFALFTFLCFTTPHFGetg 118
Cdd:cd06174 15 ISPLLPALLQSFG-LSASQLGLLFALFSLGYALLQPLAGLLADRFG-----RRPVLLLGLLLFALGALLFAFAPSFW--- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 119 nmvYAYITYILLGMSFSMQTIPVNSLTGRMTNSvEERTVLTTTRMILVYIGILLSiscatPLATAIGGENQAFGFQMTAL 198
Cdd:cd06174 86 ---LLLLGRFLLGLGSGLIDPAVLALIADLFPE-RERGRALGLLQAFGSVGGILG-----PLLGGILASSLGFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 199 IYAAVSIVLNLFSFFTVRE-----RIQPKKRKKQGIKKTLSVLFRNKPLLIL-ISSFLAFAIGFNIKLSTMVYYFTYNVN 272
Cdd:cd06174 157 IAAALALLAAILLLLVVPDppesaRAKNEEASSKSVLKLLKRVLKNPGLWLLlLAIFLVNLAYYSFSTLLPLFLLDLGGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 273 HKEFVFLGTVLFFGAALISNLFIPFFSEK-WGRKQVMIITAGLSLISYAGLHFTPYSSITLIFIWLFVSGFFTTPLNTLA 351
Cdd:cd06174 237 SVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFA 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 982922748 352 WGMVADCVDYAewktgvradGVVISSMSFINKLGVALAGSFSAIYLGIAG 401
Cdd:cd06174 317 LIAELFPPEIR---------GTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
|
|
| MFS_NLS1_MFSD2A |
cd17451 |
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ... |
22-403 |
2.73e-10 |
|
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341009 Cd Length: 419 Bit Score: 62.14 E-value: 2.73e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 22 RIGYGFGDMSYNIVFQFVNAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTN-TRWGKARPYLLWVAFP 100
Cdd:cd17451 1 KLCYAIGGAPYQITGCALGFFLQIYLLDVAQLDPFYASIILFVGRAWDAITDPTVGFFVSKSPwTRFGRLMPWIIFSTPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 101 FALFTFLCFTTPHFgETGNMVYAYITYILLGMSFSMQTIPVNSLTGRMTNSVEERTVLTTTRMILVYIGillsiscaTPL 180
Cdd:cd17451 81 AVLSYFLIWFVPDF-SQGKVMWYLLFYCLFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLG--------TVL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 181 ATAIGGE--NQAfGFQMTALIYAAVSIVLNLFSFFTVRERIQPKKRKK---QGIKKTLSVLFRNKPLLILISSFLAFAIG 255
Cdd:cd17451 152 GTAIQGQivGMA-AYMIAAGVICAIYVLCAIILFLGVREQREPCELKSqkpVSFFKGLKLVMSHGPYIKLITGFLFTSLA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 256 FNIKLSTMVYYFTYNVN-HKEFVFLGTVLFFGAALIsnlfIPF---FSEKWGRKQVMIITAGlSLISYAGLHFTPYSSIT 331
Cdd:cd17451 231 FMLLEGNFALFCTYTLGfRNDFQNILLVIMLSATLT----IPFwqwFLTRFGKKTAVYIGIS-SAVPFLILVVLVESNLI 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 982922748 332 LIFIWLFVSGFFTTPLNTLAWGMVADCVDYAEWK--TGVRADGVVISSMSFINKLGVALAGSFSAIYLGIAGYV 403
Cdd:cd17451 306 VTYVVSVAAGVSVAAAFLLPWSMLPDVVDDFKLKnpDSQGHEAIFYSFYVFFTKFASGVSLGISTLSLDFAGYQ 379
|
|
| MFS_MFSD12 |
cd17491 |
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ... |
22-384 |
4.19e-10 |
|
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341044 Cd Length: 438 Bit Score: 61.50 E-value: 4.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 22 RIGYGFGDMSYNIVFQFVNAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKAR--------PY 93
Cdd:cd17491 1 RIAYGVGHVLNDLCASMWFTYLLVYFHLVLGFSSALAGILLLIGQVADAISTPLVGYESDRTNGCGKYGRrkswhligTI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 94 LLWVAFPFaLFTFLCFTTPHFGETGNMVYAYITYILLGMSFSMQTIPVNSLTGRMTNSVEERTVLTTTRM-------ILV 166
Cdd:cd17491 81 CVLLSFPF-IFNPCLGCSDSTSEWAKLVYYGPFIIIFQFGWAAVQISHLSLIPELTSDEHERVELTALRYaftvianITV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 167 YI--GILLSISCATPLATAIGGENQAfgFQMTALIYAAVSIVLNLFSFFTVRERIQPKKRKKQGIKKTLSVLFRNKPLLI 244
Cdd:cd17491 160 YLiaWLLLQQSSGDSVNPTSAQDLPI--FRNLSLIVVGIGFLFSLLFHLGTKEPRPPTDLSTTTNEGEEVTAPEEPRLTW 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 245 --LISSFLAFAIGF---------NIKLSTMVYYFTYNVN-HKEFVFLGTVLFFGAALISNLFIPFFSEKWGRKQVMIITA 312
Cdd:cd17491 238 keWLREPQFYQVALlymctrlivNLSQVYIPLYLTETLQlPKESIAIVPLVMYVSGFLTSLVMKPINKKIGRKITYLLGL 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 982922748 313 GLSLISYAGLHFTPYSSIT-LIFIWLFVSGFFTTPLNTLAWGMVADCVDyaewkTGVRADGVVISSMSFINKL 384
Cdd:cd17491 318 LFVLGFCIWVWFQSGSSRTyEIYGAAVLLGVGSATLLVTSLSMTADLIG-----TNTESGAFVYGAMSFTDKL 385
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
54-404 |
2.19e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 58.73 E-value: 2.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 54 QPAVIATLFLVVRvldAIFDPIMGLILDKTNTRWGkarpyLLWVAFPFALFTFLCFTTPhfgetgNMVYAYITYILLGMS 133
Cdd:COG2271 46 QLGLLASAFFLGY---ALGQIPAGLLADRFGRRRV-----LAIGLLLWGLATLLFGFAT------SFWQLLLLRFLLGLG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 134 FSMQTIPVNSLTGRMTnSVEERTVLTTTRMILVYIGILLsiscATPLATAIggeNQAFGFQMTALIYAAVSIVLNLFSFF 213
Cdd:COG2271 112 EAGFFPAALKLIAEWF-PPKERGRALGIFNAGGPLGGAL----APPLLGWL---LAAFGWRAAFLILGLPGLLLALLRFW 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 214 TVreriqpkkrkkqgikkTLSVLFRNKPLLILIS---SFLAFAIGFNIKLSTMVYyftynvnhkefvflgtVLFFGAALI 290
Cdd:COG2271 184 LL----------------ALAYFLVYFALYGFLTwlpTYLVEVRGLSLAQAGLLL----------------SLPFLAGIV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 291 SNLFIPFFSEKWGR--KQVMIITAGLSLISYAGLHFTPysSITLIFIWLFVSGFFTTPLNTLAWGMVADCVdyaewktGV 368
Cdd:COG2271 232 GSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLP--SPALAIALLFLAGFGLGGAFGLLWALAAELF-------PK 302
|
330 340 350
....*....|....*....|....*....|....*.
gi 982922748 369 RADGVVISSMSFINKLGVALAGSFSAIYLGIAGYVA 404
Cdd:COG2271 303 KARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
26-357 |
1.57e-08 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 56.48 E-value: 1.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 26 GFGDMSYNIVFQFVNAYLLFYYTDVGgIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWVAFPFALFT 105
Cdd:cd17313 5 GFGFFGIEFGWALENSYVPPILQTLG-LSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAALGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 106 FLCFTTPHFGET---GNMVYAYITYIL--LGMSFSMQTI--PVNSLTGRMTNSVEERTVLTTTRMILVYIGILLSISCAT 178
Cdd:cd17313 84 ILIPNAADIGLAlgdGPRTWALVLFVLgiVLLDFAMNVCqgPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 179 PLATAIGGENQAFGFQMTALIYAAVSIVLNLFSFFTVRER----IQPKKRKKQGIKKTLSVL---FRNKP---LLILISS 248
Cdd:cd17313 164 LWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPplspEAGEHSENPSLGEVLKSLlklLKIMPrslLRLLLVI 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 249 FLAF------------AIGFNIKLSTMVYYFTYNVNHKEFVFlGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAGLSL 316
Cdd:cd17313 244 FFWWiaffpfelfftdYMGEEVYHGTSAASSHYGAGVRMGAW-GLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFA 322
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 982922748 317 ISYAGLHFTPysSITLIFIWLFVSGFFTTPLNTLAWGMVAD 357
Cdd:cd17313 323 VGMALMALVH--NVTVALVLFALGGIGWATININPYPLVSD 361
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
34-389 |
2.19e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 55.89 E-value: 2.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 34 IVFQFVNAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDktntRWGkARPYLLWVAFPFALFTFLCFTTPh 113
Cdd:pfam07690 10 LGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD----RFG-RRRVLLIGLLLFALGLLLLLFAS- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 114 fgetgNMVYAYITYILLGMSFSMQTIPVNSLTGRMTnSVEERtvltTTRMILVYIGILLSISCATPLATAIGgenQAFGF 193
Cdd:pfam07690 84 -----SLWLLLVLRVLQGLGAGALFPAALALIADWF-PPEER----GRALGLVSAGFGLGAALGPLLGGLLA---SLFGW 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 194 QMTALIYAAVSIVLNLFSFFTVRE----RIQPKKRKKQGIKKTLSVLFRNKPLLILISSFLAFAIGFNIKLSTMVYYFTY 269
Cdd:pfam07690 151 RAAFLILAILSLLAAVLLLLPRPPpeskRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 270 NVNHKEFVFLGtVLFFGAALISNLFIPFFSEKWGRKQVMIITAGLSLISYAGLHFTPYSSITLIFIW-LFVSGFFTTPLN 348
Cdd:pfam07690 231 GLSALLAGLLL-GLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLaLLLLGFGFGLVF 309
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 982922748 349 TLAWGMVADcvdyaewKTGVRADGVVISSMSFINKLGVALA 389
Cdd:pfam07690 310 PALNALVSD-------LAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
70-352 |
5.42e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 48.31 E-value: 5.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 70 AIFDPIMGLILDktntRWGKaRPYLLWVAFPFALFTFLCFTTPHFGETgnMVYAYITYILLGMSFSMQTipvnSLTGRMT 149
Cdd:cd17324 48 ALGALLLGPLSD----RIER-RRLLLVLLLLFILGNLLAALAPSFALL--LLARALAGLAHGGFWAIAA----AYAADLV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 150 nSVEERTVLTTTRMILVYIGILLSIscatPLATAIGgenQAFGFQMTALIYAAVSIVLNLFSFFTVReRIQPKKRKKQGI 229
Cdd:cd17324 117 -PPEKRGRAIGLVFSGLTLGLVLGR----PLGGLLG---QLLGWRAAFLAIAVLALLAALLLWRLLP-SLPPKKPGSLGL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 230 KKTLSVLFRNKPL-LILISSFLAFAiGFNIKLSTMVYYFTYNVNHKEFVFLGTVLFFG-AALISNLFIPFFSEKWGRKQV 307
Cdd:cd17324 188 LSSLLLLLRNPRLrLAYLITFLLFG-GFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGvAGVVGSPLAGRLADRGGRRAL 266
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 982922748 308 MIITAGLSLISYAGLHFTPYSSITLIFIWLFVSGFFTTPLNTLAW 352
Cdd:cd17324 267 LIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTR 311
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
52-360 |
1.07e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 47.57 E-value: 1.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 52 GIQPAVIATLFLVVRVLDAIFDPIMGLILDktntRWGKaRPYLLWVAFPFALFTFLCFTTPHFGETgnmvyaYITYILLG 131
Cdd:cd17325 27 GASVAQIGLIVAAYALAQLLFSPPAGRLSD----RFGR-KRLLLLGLLLLAVSTLLFAFATSYWQL------LLARFLQG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 132 MSFSMQTIPVNSLTGRMTNSVEERTVltttrMILVYIGILLSISCATPLATAIGgenQAFGFQMTALIYAAVSIVLNLFS 211
Cdd:cd17325 96 LASAAVWPAAMALIADIAPPEERGRA-----MGIFSSAIGLGFLIGPLLGGLLA---DALGYRAPFLVCAALALLALVLA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 212 FFTVRERIQPK---KRKKQGIKKTLSVLFRNKPLLILISSFLAFAIGFNIKLSTMVYYFTYNVNHKEFVfLGTVL--FFG 286
Cdd:cd17325 168 LLLLPEPRPPPnkrAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQ-IGLLFgaQGL 246
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 982922748 287 AALISNLFIPFFSEKWGRKQVMIITAGLSLISYAGLHFTPysSITLIFIWLFVSGFFTTPLNTLAWGMVADCVD 360
Cdd:cd17325 247 ASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT--SFWLLLLLLALLGLGLGLVFPATLALLADIVP 318
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
233-404 |
4.52e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 45.29 E-value: 4.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 233 LSVLFRNKPLLILISSFLAFAIGFNIKLSTMVYYFTYNVN-HKEFVFLGTVLFFGAALISNLFIPFFSEKWGRKQVMIIT 311
Cdd:cd17316 170 LLALLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGlSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIG 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 312 AGLSLISYAGLHFTPYSSITLIFIWLFVSGFFTTPLNTLAWGMVADcvdyaEWKTGVRADGV-VISSMSFINKLGVALAG 390
Cdd:cd17316 250 LILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAE-----LFPTEVRATGVgLSYNLGRLGGGGAPPLI 324
|
170
....*....|....
gi 982922748 391 SFSAIYLGIAGYVA 404
Cdd:cd17316 325 ALLLASTGGTGVPA 338
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
189-357 |
1.81e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 43.72 E-value: 1.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 189 QAFGFQMTALIYAAVSIVLNLFSFFTVRERIQPKKRKKQGIKKTLSVLFRNKPLLILISSFLAFAIGFNIKLSTMVYYFT 268
Cdd:COG2223 154 AAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLV 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 269 --YNVNHKEFVFLGTVLFFGAALISnLFIPFFSEKWGRKQVMIITAGLSLISYAGLHFTPySSITLIFIWLFVSGFFTTP 346
Cdd:COG2223 234 dqFGLSAATAGLLAALFALLGALGR-PLGGWLSDRIGGRRVLLIVFALMALGLLLLALAL-GSLWLFLVLFLLLGLALGG 311
|
170
....*....|.
gi 982922748 347 LNTLAWGMVAD 357
Cdd:COG2223 312 GNGAVFALVPD 322
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
240-404 |
2.62e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 43.28 E-value: 2.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 240 KPLLILISSFLAFAIGFNIKLSTMVYYFTYNVNHKEFVFLGTVLFfgAALISNLFIPFF---SEKWGRKQVMIITAGLSL 316
Cdd:cd17369 228 RALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLI--ASVVAAITIPLFgwlSDRVGRRPVYLAGALLAA 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 317 ISYAGLHFTPYSSITLIFIWLFVSGFFTtpLNTLAWGMVADCvdYAE-WKTGVRAdgvviSSMSFINKLGVALAGSFSAI 395
Cdd:cd17369 306 LFAFPFFWLLDTGSTWLIVLAAVVVLGV--LHGMMYGPQAAF--LAElFPTRVRY-----TGASLGYQLGAILGGGFAPL 376
|
170 180
....*....|....*....|
gi 982922748 396 -----------YLGIAGYVA 404
Cdd:cd17369 377 iatalvaatgsWWPVALYLA 396
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
242-359 |
3.48e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.60 E-value: 3.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 242 LLILISSFLAFAIGFNIKLSTMVYYFTYNVnHKEFVFLGTVLFFGA--ALISNLFIPFFSEKWGRKQVMIITAGLSLISY 319
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQL-GLSASIVGLVLALSAvaGIVASLIGGRLADRFGRKPVMLAGLLLRALGF 79
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 982922748 320 AGLHFtpYSSITLIFIWLFVSGFFTTPLNTLAWGMVADCV 359
Cdd:cd17329 80 ALLGF--AHSPWLFAIALVLTGFGGGLFEPASEAMIADVT 117
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
180-357 |
4.19e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 42.53 E-value: 4.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 180 LATAIGGENQAFGFQMTALIYAAVSIVLNLFSFFTVRERIQPKKRKKQGIKKTLSVLFRNKPLLILISSFLAFAIGFNIK 259
Cdd:COG0738 150 LGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAI 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 260 LSTMVYYFTYNVNHKEFVF-LGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAGLSLISYAGLHFTPYSSITLIFiwLF 338
Cdd:COG0738 230 GDWLPLYLKDVLGLSEATAaLGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIG--LA 307
|
170
....*....|....*....
gi 982922748 339 VSGFFTTPLNTLAWGMVAD 357
Cdd:COG0738 308 LVGLGLSLMFPTIFSLALD 326
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
237-342 |
4.65e-04 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 42.22 E-value: 4.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 237 FRNKPLLILISsFL------AFAIGFNIKLSTMVYYFTYNVNHKEFVFlgtVLFFGAALISNLFIPFFSEKWGRKQVMII 310
Cdd:PRK03699 2 NSNRIKLTWIS-FLsyaltgALVIVTGMVMGPIAEYFNLPVSSMSNTF---TFLNAGILISIFLNAWLMEIIPLKRQLIF 77
|
90 100 110
....*....|....*....|....*....|..
gi 982922748 311 TAGLSLISYAGLHFTPysSITLIFIWLFVSGF 342
Cdd:PRK03699 78 GFALMILAVAGLMFSH--SLALFSIAMFVLGV 107
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
35-349 |
6.27e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.83 E-value: 6.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 35 VFQFVNAYLLFYYTDvggiQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWgkarpyLLWVAFPFALFTFLCFTTPHF 114
Cdd:cd06173 17 IFTVALPWLVLQLTG----SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRR------LLILADLLRALLAAVLALLAL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 115 GETGNMVYAYITYILLGMSFSMQTIPVNSLTGRMTNSvEERTVLTTTRMILVYIGILLSISCATPLATAIGGEnqaFGFQ 194
Cdd:cd06173 87 LGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPK-EQLVRANALNSLATQLARIIGPALGGLLVALLGPG---GAFA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 195 MTALIYAAVSIVLNLFSFFTVRERIQPKKRKKQGIKKTLSVLFRNKPLLILISSFLAFAIGFNIKLSTMVYYF--TYNVN 272
Cdd:cd06173 163 INALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAkeVLGGG 242
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 982922748 273 HKEFVFLGTVLFFGAaLISNLFIPFFSEKWGRKQVMIITAGLSLISYAGLHFTPysSITLIFIWLFVSGFFTTPLNT 349
Cdd:cd06173 243 AAGYGLLLAAFGVGA-LLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSP--SLWLLLAALFLLGLAGGLFNV 316
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
238-398 |
1.38e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.99 E-value: 1.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 238 RNKPLLILISSFLAFAIGFNIkLSTMVYYF--TYNVNHkEFVFLGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAGLS 315
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATAL-WGPLIPALkdAFGLSD-AQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 316 LISYAGLHFTPysSITLIFIWLFVSGFFTTPLNTLAWGMVADCvdyaewktGVRADGVVISSMSFINKLGVALAGSFSAI 395
Cdd:COG0738 84 ALGLLLFALAP--SYPLLLLALFLLGLGLGLLDVAANPYVAAL--------GPETAASRLNLLHAFFSLGALLGPLLGGL 153
|
...
gi 982922748 396 YLG 398
Cdd:COG0738 154 LIL 156
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
191-406 |
1.39e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.60 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 191 FGFQMTALIYAAVSIVLNLFSFFTVRERIQPKKRKKQGIKKTLSVLFRNKPLLILISSFLAFAigfNIKLSTMVYYFTYN 270
Cdd:cd17370 153 GNYRTIFLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALG---NFSFAFLILRAQEL 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 271 VNHKEFVFLGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAGLSLISYAGLHFTPYSsitlifiWLFVSGFFttplntl 350
Cdd:cd17370 230 GLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSL-------WLLLLGFI------- 295
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 982922748 351 AWGmvadcVDYAEWKTGVRAdgvVISSMSFINKLGVALaGSFSAIYlGIAGYVANA 406
Cdd:cd17370 296 LWG-----LYMGAQESIERA---AVADLVPAELRGTAY-GLFNTVV-GIGWLLASL 341
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
168-342 |
2.68e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.88 E-value: 2.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 168 IGILLSISCATPLATAIGgenQAFGFQMTAlIYAAVSIVLNLFSFFTVRERIQPKKRKKQGIKKTLSVLFRNKPLLILIS 247
Cdd:cd17489 127 LATTLAMALGPALGLFLY---QHLGFAVLF-IVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALI 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 248 SFLAFAIGFNIKLSTMVYYFTYNVNHKEFVFLgtvLFFGAALISNLFIPFFSEKWGRKQVMIITAGLSLISYAGLHFTPY 327
Cdd:cd17489 203 LFLASIAYGAISTFLPLYAAERGISNAGLFFT---VYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGS 279
|
170
....*....|....*
gi 982922748 328 SSITLIFIWLFVSGF 342
Cdd:cd17489 280 PWMLLLAAVLYGLGF 294
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
272-360 |
3.88e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 39.10 E-value: 3.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 272 NHKEFVFLGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAGLSLISYAGLHFTPYSSITLIFiwLFVSGFFTTPLNTLA 351
Cdd:cd17317 22 DRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVL--RFLVGVTSAGIFTVG 99
|
....*....
gi 982922748 352 WGMVADCVD 360
Cdd:cd17317 100 FVLGMEIVG 108
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
179-344 |
3.89e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.46 E-value: 3.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 179 PLATAIGGENQAFGFQMTALIYAAVSIVLNLFSFFTVRERIQPKKRKKQGIKKTLSVLFRNKPLLILISSFLAFAIgfni 258
Cdd:cd17478 136 PLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVL---- 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 259 kLSTMVYYFTYNVNHKEFVFLGTV---LFFGAALISNLFIPFFSEKWGRKQVMIITAGLSLISYAGLhftPYSSITLIFI 335
Cdd:cd17478 212 -SSLTTFLPFYLVQRGYSLVFAGLllsLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLF---LLTPGIWSYI 287
|
....*....
gi 982922748 336 WLFVSGFFT 344
Cdd:cd17478 288 LLVLAGFLL 296
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
23-149 |
4.19e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 39.10 E-value: 4.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 23 IGYGFGDMSYNIVFQFVNAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDktntRWGKaRPYLLWVAFPFA 102
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSD----RIGR-KPLILIGLLLSA 276
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 982922748 103 LFTFLCFTTPHFgetgnmVYAYITYILLGMSFSMQTIPVNSLTGRMT 149
Cdd:cd17325 277 VALLLLPLATSF------WLLLLLLALLGLGLGLVFPATLALLADIV 317
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
236-347 |
4.62e-03 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 39.26 E-value: 4.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 236 LFRNKPLLILISSFLAFAIGFNIKLSTMVYYFTYNVN-HKEFVFLGTVLFFGAALISNLFIPFFSEKWGRKQVMII-TAG 313
Cdd:cd17366 189 LYLRRPLLICIGLVLVFNVTNYMLLSYMPSYLEETLGySETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAgLAG 268
|
90 100 110
....*....|....*....|....*....|....
gi 982922748 314 LSLISYAGLHFTPYSSITLIFIWLFVSGFFTTPL 347
Cdd:cd17366 269 LLVLAVPAFLLMNSGSIAAIFIGLLVLGLLLSCY 302
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
75-357 |
6.64e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.69 E-value: 6.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 75 IMGLILDKTNTRWGKARPYLLWVAFPFALFTFLCFTTphfgetgNMVYAYITYILLGMSFSMQTIPVNSLTGRMTNSvEE 154
Cdd:cd17477 46 LGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD-------SPWVWFLLRFVMGIGLAGLFVVSESWLNALATN-EN 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 155 RTVLTTTRMILVYIGILLSiscatPLATAIGGENQAFGFQMTALIYAAvSIVLNLFSFFTVRERIQPKKRkkqgikkTLS 234
Cdd:cd17477 118 RGRVLGLYSTVLGLGFALG-----PLLLALVGTAGALPFLIAAVLLLL-ALVPLLLTRRAAPEIEEAESI-------SLR 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982922748 235 VLFRNKPLLILISsfLAFAIGFNIKLSTMVYYFTYN-VNHKEFVFLGTVLFFGAALISnLFIPFFSEKWGRKQVMIITAG 313
Cdd:cd17477 185 RLLRIAPLALLGA--FVAGFLEGAFYSLLPLYGLRLgLSVAQAALLLAAFVLGGLLLQ-WPLGWLADRFDRRRVLLGCAL 261
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 982922748 314 LSLISYAGLHFTPYSSItLIFIWLFVSGFFTTPLNTLAWGMVAD 357
Cdd:cd17477 262 LGALAALLLPLVPGLPL-ALLVLLFLWGGAAGPLYTLALALAGD 304
|
|
| |
