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Conserved domains on  [gi|983529560|ref|WP_060681300|]
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cytochrome aa3 quinol oxidase subunit IV [Virgibacillus halodenitrificans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COX4_pro super family cl01204
Prokaryotic Cytochrome C oxidase subunit IV; Cytochrome c oxidase (COX) is a multi-subunit ...
 8-99 8.40e-17

Prokaryotic Cytochrome C oxidase subunit IV; Cytochrome c oxidase (COX) is a multi-subunit enzyme complex that catalyzes the final step of electron transfer through the respiratory chain on the mitochondrial inner membrane. This family is composed of cytochrome c oxidase subunit 4 from prokaryotes.


The actual alignment was detected with superfamily member TIGR02901:

Pssm-ID: 445313  Cd Length: 94  Bit Score: 69.77  E-value: 8.40e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983529560    8 IPTNHIVGFLLSLVMTIVAAWAALQSDLPVMWIIIGIMALAVLQAGVQLFMFMHVTESASGNGHVpWNMMFhGFALAAIV 87
Cdd:TIGR02901   5 FPWKHVMGFILSLILTLLALWVAFYSDLSLVVGLTIIIVFAFIQASLQLIVFMHINEGNDGKVQI-YNIGY-AAFIALVT 82

                          90
                  ....*....|..
gi 983529560   88 VAGSLFTMSFGF 99
Cdd:TIGR02901  83 VFGSLWVMIWGY 94
 
Name Accession Description Interval E-value
QoxD TIGR02901
cytochrome aa3 quinol oxidase, subunit IV; This family (QoxD) encodes subunit IV of the ...
 8-99 8.40e-17

cytochrome aa3 quinol oxidase, subunit IV; This family (QoxD) encodes subunit IV of the aa3-type quinone oxidase, one of several bacterial terminal oxidases. This complex couples oxidation of reduced quinones with the reduction of molecular oxygen to water and the pumping of protons to form a proton gradient utilized for ATP production. aa3-type oxidases contain two heme a cofactors as well as copper atoms in the active site. [Energy metabolism, Electron transport]


Pssm-ID: 200218  Cd Length: 94  Bit Score: 69.77  E-value: 8.40e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983529560    8 IPTNHIVGFLLSLVMTIVAAWAALQSDLPVMWIIIGIMALAVLQAGVQLFMFMHVTESASGNGHVpWNMMFhGFALAAIV 87
Cdd:TIGR02901   5 FPWKHVMGFILSLILTLLALWVAFYSDLSLVVGLTIIIVFAFIQASLQLIVFMHINEGNDGKVQI-YNIGY-AAFIALVT 82

                          90
                  ....*....|..
gi 983529560   88 VAGSLFTMSFGF 99
Cdd:TIGR02901  83 VFGSLWVMIWGY 94
CyoD COG3125
Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion];
12-95 6.05e-13

Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion];


Pssm-ID: 442359  Cd Length: 109  Bit Score: 60.21  E-value: 6.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983529560  12 HIVGFLLSLVMTIVAAWAALQSDLPVMWIIIGIMALAVLQAGVQLFMFMHVTESASGNghvpWNMMFHGFA--LAAIVVA 89
Cdd:COG3125   18 YLIGFVLSVILTAIPFWLVMTGALSPGTTLAVILGLAVVQIVVHLVYFLHMNTSSEGR----WNLLALIFTvlIVVIVVG 93


                 ....*.
gi 983529560  90 GSLFTM 95
Cdd:COG3125   94 GSLWIM 99
COX4_pro pfam03626
Prokaryotic Cytochrome C oxidase subunit IV; Cytochrome c oxidase (COX) is a multi-subunit ...
 13-88 1.12e-06

Prokaryotic Cytochrome C oxidase subunit IV; Cytochrome c oxidase (COX) is a multi-subunit enzyme complex that catalyzes the final step of electron transfer through the respiratory chain on the mitochondrial inner membrane. This family is composed of cytochrome c oxidase subunit 4 from prokaryotes.


Pssm-ID: 427408  Cd Length: 72  Bit Score: 42.85  E-value: 1.12e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 983529560   13 IVGFLLSLVMTIVAAWAALQSDLPVMWIIIgIMALAVLQAGVQLFMFMHVTESASGnghvpWNMMFHGFALAAIVV 88
Cdd:pfam03626   1 LIVFVLLLILTAITFALVYAGLGGLAAIIA-ILVLAVVKALLILLYFMHLKEEPRL-----WRLLALIFLVFVALL 70
PRK10582 PRK10582
cytochrome o ubiquinol oxidase subunit IV; Provisional
 12-95 5.40e-04

cytochrome o ubiquinol oxidase subunit IV; Provisional


Pssm-ID: 182568  Cd Length: 109  Bit Score: 36.66  E-value: 5.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983529560  12 HIVGFLLSLVMTIVAAWAALQSDLPVMWIIIGIMALAVLQAGVQLFMFMHVTESASGNghvpWNMMFHGFA--LAAIVVA 89
Cdd:PRK10582  18 YMTGFILSIILTVIPFWMVMTGAASPAVILGTILAMAVVQILVHLVCFLHMNTKSDEG----WNMTAFVFTvlIIAILVV 93


                 ....*.
gi 983529560  90 GSLFTM 95
Cdd:PRK10582  94 GSIWIM 99
 
Name Accession Description Interval E-value
QoxD TIGR02901
cytochrome aa3 quinol oxidase, subunit IV; This family (QoxD) encodes subunit IV of the ...
 8-99 8.40e-17

cytochrome aa3 quinol oxidase, subunit IV; This family (QoxD) encodes subunit IV of the aa3-type quinone oxidase, one of several bacterial terminal oxidases. This complex couples oxidation of reduced quinones with the reduction of molecular oxygen to water and the pumping of protons to form a proton gradient utilized for ATP production. aa3-type oxidases contain two heme a cofactors as well as copper atoms in the active site. [Energy metabolism, Electron transport]


Pssm-ID: 200218  Cd Length: 94  Bit Score: 69.77  E-value: 8.40e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983529560    8 IPTNHIVGFLLSLVMTIVAAWAALQSDLPVMWIIIGIMALAVLQAGVQLFMFMHVTESASGNGHVpWNMMFhGFALAAIV 87
Cdd:TIGR02901   5 FPWKHVMGFILSLILTLLALWVAFYSDLSLVVGLTIIIVFAFIQASLQLIVFMHINEGNDGKVQI-YNIGY-AAFIALVT 82

                          90
                  ....*....|..
gi 983529560   88 VAGSLFTMSFGF 99
Cdd:TIGR02901  83 VFGSLWVMIWGY 94
CyoD COG3125
Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion];
12-95 6.05e-13

Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion];


Pssm-ID: 442359  Cd Length: 109  Bit Score: 60.21  E-value: 6.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983529560  12 HIVGFLLSLVMTIVAAWAALQSDLPVMWIIIGIMALAVLQAGVQLFMFMHVTESASGNghvpWNMMFHGFA--LAAIVVA 89
Cdd:COG3125   18 YLIGFVLSVILTAIPFWLVMTGALSPGTTLAVILGLAVVQIVVHLVYFLHMNTSSEGR----WNLLALIFTvlIVVIVVG 93


                 ....*.
gi 983529560  90 GSLFTM 95
Cdd:COG3125   94 GSLWIM 99
COX4_pro pfam03626
Prokaryotic Cytochrome C oxidase subunit IV; Cytochrome c oxidase (COX) is a multi-subunit ...
 13-88 1.12e-06

Prokaryotic Cytochrome C oxidase subunit IV; Cytochrome c oxidase (COX) is a multi-subunit enzyme complex that catalyzes the final step of electron transfer through the respiratory chain on the mitochondrial inner membrane. This family is composed of cytochrome c oxidase subunit 4 from prokaryotes.


Pssm-ID: 427408  Cd Length: 72  Bit Score: 42.85  E-value: 1.12e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 983529560   13 IVGFLLSLVMTIVAAWAALQSDLPVMWIIIgIMALAVLQAGVQLFMFMHVTESASGnghvpWNMMFHGFALAAIVV 88
Cdd:pfam03626   1 LIVFVLLLILTAITFALVYAGLGGLAAIIA-ILVLAVVKALLILLYFMHLKEEPRL-----WRLLALIFLVFVALL 70
CyoD TIGR02847
cytochrome o ubiquinol oxidase subunit IV; Cytochrome o terminal oxidase complex is the ...
 13-96 2.25e-06

cytochrome o ubiquinol oxidase subunit IV; Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain which reacts with oxygen, reducing it to water with the concomitant transport of 4 protons across the membrane. Also known as the cytochrome bo complex, cytochrome o ubiquinol oxidase contains four subunits, two heme b cofactors and a copper atom which is believed to be the oxygen active site. This complex is structurally related to the cytochrome caa3 oxidases which utilize cytochrome c as the reductant and contain heme a cofactors, as well as the intermediate form aa3 oxidases which also react directly with quinones as the reductant. [Energy metabolism, Electron transport]


Pssm-ID: 131894  Cd Length: 96  Bit Score: 42.61  E-value: 2.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983529560   13 IVGFLLSLVMTIVAAWAALQSDLPVMWIIIGIMALAVLQAGVQLFMFMHVTESASGNghvpWNMMFHGFAL--AAIVVAG 90
Cdd:TIGR02847   8 LIGFVLSVILTAIPFGLVMSGTLSKGLTLVIIIVLAVVQILVHLVFFLHLNTSSEQR----WNLISLLFTIliIFILIGG 83


                  ....*.
gi 983529560   91 SLFTMS 96
Cdd:TIGR02847  84 SIWIMH 89
PRK10582 PRK10582
cytochrome o ubiquinol oxidase subunit IV; Provisional
 12-95 5.40e-04

cytochrome o ubiquinol oxidase subunit IV; Provisional


Pssm-ID: 182568  Cd Length: 109  Bit Score: 36.66  E-value: 5.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 983529560  12 HIVGFLLSLVMTIVAAWAALQSDLPVMWIIIGIMALAVLQAGVQLFMFMHVTESASGNghvpWNMMFHGFA--LAAIVVA 89
Cdd:PRK10582  18 YMTGFILSIILTVIPFWMVMTGAASPAVILGTILAMAVVQILVHLVCFLHMNTKSDEG----WNMTAFVFTvlIIAILVV 93


                 ....*.
gi 983529560  90 GSLFTM 95
Cdd:PRK10582  94 GSIWIM 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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