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Conserved domains on  [gi|1000883377|ref|WP_061139842|]
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MULTISPECIES: methyl-accepting chemotaxis protein [Bacillus]

Protein Classification

methyl-accepting chemotaxis protein( domain architecture ID 11435591)

methyl-accepting chemotaxis protein (MCP) is a bacterial receptor that mediates chemotaxis to diverse signals, responding to changes in the concentration of attractants and repellents in the environment by altering swimming behavior

CATH:  1.10.287.950
Gene Ontology:  GO:0006935
PubMed:  18165013|20738376
SCOP:  4003862

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
31-578 9.93e-64

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


:

Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 218.35  E-value: 9.93e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377  31 ALSFNMFQSSMMSIFERQSFETGDTVINQLDVEIVRDVAKDPTEQRVKKEKLTEQLDKAIKDMKSVGQTYVTGAKLNDKA 110
Cdd:COG0840    12 LALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 111 ELQIVALDTKLANTVSVKPGEYYEQPTYWMKTYDKVIQTKQAQMTEVYEDELGFWVTILEPVTDENKNIIAIVAADLDAS 190
Cdd:COG0840    92 LLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 191 IIPLTKKQFMIQGLLFFIISLTIAITIQIFISRNSLSPLKDLQEGLRKVGEGDLSIKLNERSDD-IGITNIYFNNTIKKF 269
Cdd:COG0840   172 LALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDeIGQLADAFNRMIENL 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 270 NSIIDKVRQTAEQVSTSSQELSVSTKENSIAFKEIASAItglnlgthsheyvvQKCLGIVQEMESKMKEIKGAAKQVGNA 349
Cdd:COG0840   252 RELVGQVRESAEQVASASEELAASAEELAAGAEEQAASL--------------EETAAAMEELSATVQEVAENAQQAAEL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 350 LEDMDQHSVEGKDLIKQIVNQMKRIKDTVQDVSSSIYALEVRSKEIHEILTVITTISNQTNSLALNASTESSCAGEMGEE 429
Cdd:COG0840   318 AEEASELAEEGGEVVEEAVEGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRG 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 430 FSGVADEVRILAERTEASARDIAKLIGETQAEAERAVKSIQKSSKEVESGITLVQSSGAFFEKISESAQSVTNQIKANSN 509
Cdd:COG0840   398 FAVVADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAA 477

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1000883377 510 NSSDILKDNQTIVQFVNELSHIANtyvnsssnvetsmkEQELYVQDIAELANSLNWLSQELQGLIGEFK 578
Cdd:COG0840   478 ASEEQSAGTEEVNQAIEQIAAAAQ--------------ENAASVEEVAAAAEELAELAEELQELVSRFK 532
 
Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
31-578 9.93e-64

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 218.35  E-value: 9.93e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377  31 ALSFNMFQSSMMSIFERQSFETGDTVINQLDVEIVRDVAKDPTEQRVKKEKLTEQLDKAIKDMKSVGQTYVTGAKLNDKA 110
Cdd:COG0840    12 LALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 111 ELQIVALDTKLANTVSVKPGEYYEQPTYWMKTYDKVIQTKQAQMTEVYEDELGFWVTILEPVTDENKNIIAIVAADLDAS 190
Cdd:COG0840    92 LLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 191 IIPLTKKQFMIQGLLFFIISLTIAITIQIFISRNSLSPLKDLQEGLRKVGEGDLSIKLNERSDD-IGITNIYFNNTIKKF 269
Cdd:COG0840   172 LALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDeIGQLADAFNRMIENL 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 270 NSIIDKVRQTAEQVSTSSQELSVSTKENSIAFKEIASAItglnlgthsheyvvQKCLGIVQEMESKMKEIKGAAKQVGNA 349
Cdd:COG0840   252 RELVGQVRESAEQVASASEELAASAEELAAGAEEQAASL--------------EETAAAMEELSATVQEVAENAQQAAEL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 350 LEDMDQHSVEGKDLIKQIVNQMKRIKDTVQDVSSSIYALEVRSKEIHEILTVITTISNQTNSLALNASTESSCAGEMGEE 429
Cdd:COG0840   318 AEEASELAEEGGEVVEEAVEGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRG 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 430 FSGVADEVRILAERTEASARDIAKLIGETQAEAERAVKSIQKSSKEVESGITLVQSSGAFFEKISESAQSVTNQIKANSN 509
Cdd:COG0840   398 FAVVADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAA 477

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1000883377 510 NSSDILKDNQTIVQFVNELSHIANtyvnsssnvetsmkEQELYVQDIAELANSLNWLSQELQGLIGEFK 578
Cdd:COG0840   478 ASEEQSAGTEEVNQAIEQIAAAAQ--------------ENAASVEEVAAAAEELAELAEELQELVSRFK 532
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 330-529 1.23e-48

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 167.80  E-value: 1.23e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 330 QEMESKMKEIKGAAKQVGNALEDMDQHSVEGKDLIKQIVNQMKRIKDTVQDVSSSIYALEVRSKEIHEILTVITTISNQT 409
Cdd:cd11386     1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 410 NSLALNASTESSCAGEMGEEFSGVADEVRILAERTEASARDIAKLIGETQAEAERAVKSIQKSSKEVESGITLVQSSGAF 489
Cdd:cd11386    81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1000883377 490 FEKISESAQSVTNQIKANSNNSSDILKDNQTIVQFVNELS 529
Cdd:cd11386   161 FEEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEIA 200
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 329-578 4.63e-40

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 146.66  E-value: 4.63e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377  329 VQEMESKMKEIKGAAKQVGNALEDMDQHSVEGKDLIKQIVNQMKRIKDTVQDVSSSIYALEVRSKEIHEILTVITTISNQ 408
Cdd:smart00283  27 MEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAVSAVEELEESSDEIGEIVSVIDDIADQ 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377  409 TNSLALNASTESSCAGEMGEEFSGVADEVRILAERTEASARDIAKLIGETQAEAERAVKSIQKSSKEVESGITLVQSSGA 488
Cdd:smart00283 107 TNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEIQEETNEAVAAMEESSSEVEEGVELVEETGD 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377  489 FFEKISESAQSVTNQIKANSNNSSDILKDNQTIVQFVNELSHIanTYVNSSSnvetsmkeqelyVQDIAELANSLNWLSQ 568
Cdd:smart00283 187 ALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQV--TQETAAM------------SEEISAAAEELSGLAE 252

                          250
                   ....*....|
gi 1000883377  569 ELQGLIGEFK 578
Cdd:smart00283 253 ELDELVERFK 262
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 377-531 8.39e-28

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 109.83  E-value: 8.39e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 377 TVQDVSSSIYALEVRSKEIHEILTVITTISNQTNSLALNASTESSCAGEMGEEFSGVADEVRILAERTEASARDIAKLIG 456
Cdd:pfam00015  17 EVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAERSAQAAKEIEALII 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1000883377 457 ETQAEAERAVKSIQKSSKEVESGITLVQSSGAFFEKISESAQSVTNQIKANSNNSSDILKDNQTIVQFVNELSHI 531
Cdd:pfam00015  97 EIQKQTNDSTASIESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQVNQAVARMDQV 171
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 208-549 4.34e-17

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 84.67  E-value: 4.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 208 IISLTIAITIQIF---ISRNSLSPLKDLQEGLRKVGEGDLSIKLnersddigitniyfnnTIKKFNSIIDkVRQTAEQVS 284
Cdd:PRK15048  196 VIALVVVLILLVAwygIRRMLLTPLAKIIAHIREIAGGNLANTL----------------TIDGRSEMGD-LAQSVSHMQ 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 285 TSSQELSVSTKENSIAF----KEIASAITGLNLGTHSHEYVVQKCLGIVQEMESKMKEIKGAAKQVGNALEDMDQHSVEG 360
Cdd:PRK15048  259 RSLTDTVTHVREGSDAIyagtREIAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNADNARQASQLAQSASDTAQHG 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 361 KDLIKQIVNQMKRIKDTvqdvsssiyalevrSKEIHEILTVITTISNQTNSLALNASTESSCAGEMGEEFSGVADEVRIL 440
Cdd:PRK15048  339 GKVVDGVVKTMHEIADS--------------SKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNL 404

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 441 AERTEASARDIAKLigetqaeaeravksIQKSSKEVESGITLVQSSGAFFEKISESAQSVTN---QIKANSNNSSDILKD 517
Cdd:PRK15048  405 ASRSAQAAKEIKAL--------------IEDSVSRVDTGSVLVESAGETMNNIVNAVTRVTDimgEIASASDEQSRGIDQ 470

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1000883377 518 NQTIVQFVNELSHIANTYVNSSSNVETSMKEQ 549
Cdd:PRK15048  471 VALAVSEMDRVTQQNASLVQESAAAAAALEEQ 502
 
Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
31-578 9.93e-64

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 218.35  E-value: 9.93e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377  31 ALSFNMFQSSMMSIFERQSFETGDTVINQLDVEIVRDVAKDPTEQRVKKEKLTEQLDKAIKDMKSVGQTYVTGAKLNDKA 110
Cdd:COG0840    12 LALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 111 ELQIVALDTKLANTVSVKPGEYYEQPTYWMKTYDKVIQTKQAQMTEVYEDELGFWVTILEPVTDENKNIIAIVAADLDAS 190
Cdd:COG0840    92 LLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 191 IIPLTKKQFMIQGLLFFIISLTIAITIQIFISRNSLSPLKDLQEGLRKVGEGDLSIKLNERSDD-IGITNIYFNNTIKKF 269
Cdd:COG0840   172 LALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDeIGQLADAFNRMIENL 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 270 NSIIDKVRQTAEQVSTSSQELSVSTKENSIAFKEIASAItglnlgthsheyvvQKCLGIVQEMESKMKEIKGAAKQVGNA 349
Cdd:COG0840   252 RELVGQVRESAEQVASASEELAASAEELAAGAEEQAASL--------------EETAAAMEELSATVQEVAENAQQAAEL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 350 LEDMDQHSVEGKDLIKQIVNQMKRIKDTVQDVSSSIYALEVRSKEIHEILTVITTISNQTNSLALNASTESSCAGEMGEE 429
Cdd:COG0840   318 AEEASELAEEGGEVVEEAVEGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRG 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 430 FSGVADEVRILAERTEASARDIAKLIGETQAEAERAVKSIQKSSKEVESGITLVQSSGAFFEKISESAQSVTNQIKANSN 509
Cdd:COG0840   398 FAVVADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAA 477

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1000883377 510 NSSDILKDNQTIVQFVNELSHIANtyvnsssnvetsmkEQELYVQDIAELANSLNWLSQELQGLIGEFK 578
Cdd:COG0840   478 ASEEQSAGTEEVNQAIEQIAAAAQ--------------ENAASVEEVAAAAEELAELAEELQELVSRFK 532
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 330-529 1.23e-48

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 167.80  E-value: 1.23e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 330 QEMESKMKEIKGAAKQVGNALEDMDQHSVEGKDLIKQIVNQMKRIKDTVQDVSSSIYALEVRSKEIHEILTVITTISNQT 409
Cdd:cd11386     1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 410 NSLALNASTESSCAGEMGEEFSGVADEVRILAERTEASARDIAKLIGETQAEAERAVKSIQKSSKEVESGITLVQSSGAF 489
Cdd:cd11386    81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1000883377 490 FEKISESAQSVTNQIKANSNNSSDILKDNQTIVQFVNELS 529
Cdd:cd11386   161 FEEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEIA 200
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 329-578 4.63e-40

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 146.66  E-value: 4.63e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377  329 VQEMESKMKEIKGAAKQVGNALEDMDQHSVEGKDLIKQIVNQMKRIKDTVQDVSSSIYALEVRSKEIHEILTVITTISNQ 408
Cdd:smart00283  27 MEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAVSAVEELEESSDEIGEIVSVIDDIADQ 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377  409 TNSLALNASTESSCAGEMGEEFSGVADEVRILAERTEASARDIAKLIGETQAEAERAVKSIQKSSKEVESGITLVQSSGA 488
Cdd:smart00283 107 TNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEIQEETNEAVAAMEESSSEVEEGVELVEETGD 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377  489 FFEKISESAQSVTNQIKANSNNSSDILKDNQTIVQFVNELSHIanTYVNSSSnvetsmkeqelyVQDIAELANSLNWLSQ 568
Cdd:smart00283 187 ALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQV--TQETAAM------------SEEISAAAEELSGLAE 252

                          250
                   ....*....|
gi 1000883377  569 ELQGLIGEFK 578
Cdd:smart00283 253 ELDELVERFK 262
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 377-531 8.39e-28

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 109.83  E-value: 8.39e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 377 TVQDVSSSIYALEVRSKEIHEILTVITTISNQTNSLALNASTESSCAGEMGEEFSGVADEVRILAERTEASARDIAKLIG 456
Cdd:pfam00015  17 EVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAERSAQAAKEIEALII 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1000883377 457 ETQAEAERAVKSIQKSSKEVESGITLVQSSGAFFEKISESAQSVTNQIKANSNNSSDILKDNQTIVQFVNELSHI 531
Cdd:pfam00015  97 EIQKQTNDSTASIESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQVNQAVARMDQV 171
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 208-549 4.34e-17

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 84.67  E-value: 4.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 208 IISLTIAITIQIF---ISRNSLSPLKDLQEGLRKVGEGDLSIKLnersddigitniyfnnTIKKFNSIIDkVRQTAEQVS 284
Cdd:PRK15048  196 VIALVVVLILLVAwygIRRMLLTPLAKIIAHIREIAGGNLANTL----------------TIDGRSEMGD-LAQSVSHMQ 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 285 TSSQELSVSTKENSIAF----KEIASAITGLNLGTHSHEYVVQKCLGIVQEMESKMKEIKGAAKQVGNALEDMDQHSVEG 360
Cdd:PRK15048  259 RSLTDTVTHVREGSDAIyagtREIAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNADNARQASQLAQSASDTAQHG 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 361 KDLIKQIVNQMKRIKDTvqdvsssiyalevrSKEIHEILTVITTISNQTNSLALNASTESSCAGEMGEEFSGVADEVRIL 440
Cdd:PRK15048  339 GKVVDGVVKTMHEIADS--------------SKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNL 404

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 441 AERTEASARDIAKLigetqaeaeravksIQKSSKEVESGITLVQSSGAFFEKISESAQSVTN---QIKANSNNSSDILKD 517
Cdd:PRK15048  405 ASRSAQAAKEIKAL--------------IEDSVSRVDTGSVLVESAGETMNNIVNAVTRVTDimgEIASASDEQSRGIDQ 470

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1000883377 518 NQTIVQFVNELSHIANTYVNSSSNVETSMKEQ 549
Cdd:PRK15048  471 VALAVSEMDRVTQQNASLVQESAAAAAALEEQ 502
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
207-502 5.38e-17

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 84.24  E-value: 5.38e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 207 FIISLTIAITIQIFISRNSLSPLKDLQEGLRKVGEGDLSIKLN-ERSDDIGITNIYFNNTIKKFNSIIDKVRQTAE---- 281
Cdd:PRK15041  200 MIVVLAVIFAVWFGIKASLVAPMNRLIDSIRHIAGGDLVKPIEvDGSNEMGQLAESLRHMQGELMRTVGDVRNGANaiys 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 282 ---QVSTSSQELSVSTKENSIAFKEIASAItglnlgthsheyvvqkclgivQEMESKMKEIKGAAKQVGNALEDMDQHSV 358
Cdd:PRK15041  280 gasEIATGNNDLSSRTEQQAASLEETAASM---------------------EQLTATVKQNAENARQASHLALSASETAQ 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 359 EGKDLIKQIVNQMKrikdtvqDVSSSiyalevrSKEIHEILTVITTISNQTNSLALNASTESSCAGEMGEEFSGVADEVR 438
Cdd:PRK15041  339 RGGKVVDNVVQTMR-------DISTS-------SQKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVR 404

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1000883377 439 ILAERTEASARDIAKLigetqaeaeravksIQKSSKEVESGITLVQSSGAFFEKISESAQSVTN 502
Cdd:PRK15041  405 NLAQRSAQAAREIKSL--------------IEDSVGKVDVGSTLVESAGETMAEIVSAVTRVTD 454
PRK09793 PRK09793
methyl-accepting chemotaxis protein IV;
195-559 5.85e-15

methyl-accepting chemotaxis protein IV;


Pssm-ID: 182079 [Multi-domain]  Cd Length: 533  Bit Score: 77.80  E-value: 5.85e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 195 TKKQFMIQGLLF--FIISLTIAITIQIFISRNSL-SPLKDLQEGLRKVGEGDLS--IKLNERSDdigITNIYfnntiKKF 269
Cdd:PRK09793  181 SQRNYQISALVFisMIIVAAIYISSALWWTRKMIvQPLAIIGSHFDSIAAGNLArpIAVYGRNE---ITAIF-----ASL 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 270 NSIIDKVRQTAEQVSTSSQELSvstkensIAFKEIASAITGLNLGTHsheyvvQKCLGIVQEMESkMKEIKGAAKQvgNA 349
Cdd:PRK09793  253 KTMQQALRGTVSDVRKGSQEMH-------IGIAEIVAGNNDLSSRTE------QQAASLAQTAAS-MEQLTATVGQ--NA 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 350 ledmdQHSVEGKDLIKQIVNQMKRIKDTVQDVSSSIYALEVRSKEIHEILTVITTISNQTNSLALNASTESSCAGEMGEE 429
Cdd:PRK09793  317 -----DNARQASELAKNAATTAQAGGVQVSTMTHTMQEIATSSQKIGDIISVIDGIAFQTNILALNAAVEAARAGEQGRG 391

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 430 FSGVADEVRILAERTEASARDIAKLIGETQAEAERAVKSIQKSSK---EVESGITLVQ--------SSGAFFEKISESAQ 498
Cdd:PRK09793  392 FAVVAGEVRNLASRSAQAAKEIKGLIEESVNRVQQGSKLVNNAAAtmtDIVSSVTRVNdimgeiasASEEQRRGIEQVAQ 471

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1000883377 499 SVTNQIKANSNNSSDILKDNQTIVQFVNELSHIantyvnSSSNVETSMKEQELYVQDIAEL 559
Cdd:PRK09793  472 AVSQMDQVTQQNASLVEEAAVATEQLANQADHL------SSRVAVFTLEEHEVARHESAQL 526
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
166-278 2.13e-06

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 50.40  E-value: 2.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 166 VTILEPVTDENKNIIAIVAADLDASIIPLTKKQFMIQG--------LLFFIISLTIAITIQIFISRNSLSPLKDLQEGLR 237
Cdd:COG2972   114 LLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGlfslrrliLLIILLLLLLALLLSYLLSRSITRPIKRLKKAMK 193

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1000883377 238 KVGEGDLSIKLNERSDDIGITNIYFNNTIKKFNSIIDKVRQ 278
Cdd:COG2972   194 KVEKGDLVRLEVSGNDEIGILARSFNEMVERIKELIEEVYE 234
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 196-290 2.82e-06

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 49.96  E-value: 2.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 196 KKQFMIQGLLFFIISLTIAITIQIFISRNSLSPLKDLQEGLRKVGEGDLSIKLNERSDD-IGItniyfnnTIKKFNSIID 274
Cdd:COG5000     4 QILFLLLLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDeIGE-------LARAFNRMTD 76

                          90
                  ....*....|....*.
gi 1000883377 275 KVRQTAEQVSTSSQEL 290
Cdd:COG5000    77 QLKEQREELEERRRYL 92
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
29-560 8.53e-05

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 45.49  E-value: 8.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377  29 MGALSFNMFQSSMMSIFERQSFETGDTVINQLDVEIVRDVAKDPTEQRVKKEKLTEQLDKAIKDMKSVGQTYVTGAKLND 108
Cdd:COG2770    40 LLLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALA 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 109 KAELQIVALDTKLANTVSVKPGEYYEQPTYWMKTYDKVIQTKQAQMTEVYEDELGFWVTILEPVTDENKNIIAIVAADLD 188
Cdd:COG2770   120 LLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLL 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 189 ASIIPLTKKQFMIQGLLFFIISLTIAITIQIFISRNSLSPLKDLQEGLRKVGEGDLSIKLN-ERSDDIGITNIYFNNTIK 267
Cdd:COG2770   200 LVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPvSRKDEIGELARAFNRMAD 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 268 KFNSIIDKVRQTAEQvsTSSQELSVSTKENSIAFKEIASAITGLNLGTHSHEYVVQKCLGIVQEMESKMKEIKGAAKQVG 347
Cdd:COG2770   280 SLRESIEEAEEEEEL--AEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALA 357

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 348 NALEDMDQHSVEGKDLIKQIVNQMKRIKDTVQDVSSSIYALEVRSKEIHEILTVITTISNQTNSLALNASTESSCAGEMG 427
Cdd:COG2770   358 ALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAA 437

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 428 EEFSGVADEVRILAERTEASARDIAKLIGETQAEAERAVKSIQKSSKEVESGITLVQSSGAFFEKISESAQSVTNQIKAN 507
Cdd:COG2770   438 LELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEELAEELLLLEGLLL 517

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1000883377 508 SNNSSDILKDNQTIVQFVNELSHIANTYVNSSSNVETSMKEQELYVQDIAELA 560
Cdd:COG2770   518 LLLLEAEALEVAEELLELEEAALLLAAAAELAALLALLLALAAVEAAALLLAA 570
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 226-256 1.20e-03

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 37.04  E-value: 1.20e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1000883377 226 LSPLKDLQEGLRKVGEGDLSIKLNERSDD-IG 256
Cdd:cd06225     1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDeIG 32
HAMP pfam00672
HAMP domain;
220-264 2.93e-03

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 36.06  E-value: 2.93e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1000883377 220 FISRNSLSPLKDLQEGLRKVGEGDLSIKLNERSDD-IGITNIYFNN 264
Cdd:pfam00672   1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDeIGELARAFNQ 46
NarQ COG3850
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ...
 110-254 5.18e-03

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];


Pssm-ID: 443059 [Multi-domain]  Cd Length: 448  Bit Score: 39.48  E-value: 5.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000883377 110 AELQIVALDTKLANTVSVKPGEYYEQPTYWMKTYDKVIQTKQAQMTEVYEDELGFWVTILEPVTDENKNIIAIVAADLDA 189
Cdd:COG3850    27 LLLSLLALLLLLERTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLLLLLLLLAALLSLLLLLLLLLLLLLLL 106

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1000883377 190 SIIPLTKKQFMIQGLLFFIISLTIAITIQIFISRNSLSPLKDLQEGLRKVGEGDLSIKLNERSDD 254
Cdd:COG3850   107 LLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRD 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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