MULTISPECIES: branched-chain amino acid ABC transporter substrate-binding protein [Bacillus]
Protein Classification
branched-chain amino acid ABC transporter substrate-binding protein( domain architecture ID 10156937)
branched-chain amino acid ABC transporter substrate-binding protein is a periplasmic-binding protein that functions as the primary high-affinity receptor for the active transport of branched-chain amino acids
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| PBP1_ABC_LIVBP-like | cd06342 | type 1 periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active ... |
59-351 | 2.15e-46 | |||||
type 1 periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); This subgroup includes the type 1 periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine). This subgroup also includes a leucine-specific binding protein (or LivK), which is very similar in sequence and structure to leucine-isoleucine-valine binding protein (LIVBP). ABC-type active transport systems are transmembrane proteins that function in the transport of diverse sets of substrates across extra- and intracellular membranes, including carbohydrates, amino acids, inorganic ions, dipeptides and oligopeptides, metabolic products, lipids and sterols, and heme, to name a few. : Pssm-ID: 380565 [Multi-domain] Cd Length: 334 Bit Score: 161.15 E-value: 2.15e-46
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| Name | Accession | Description | Interval | E-value | ||||||
| PBP1_ABC_LIVBP-like | cd06342 | type 1 periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active ... |
59-351 | 2.15e-46 | ||||||
type 1 periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); This subgroup includes the type 1 periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine). This subgroup also includes a leucine-specific binding protein (or LivK), which is very similar in sequence and structure to leucine-isoleucine-valine binding protein (LIVBP). ABC-type active transport systems are transmembrane proteins that function in the transport of diverse sets of substrates across extra- and intracellular membranes, including carbohydrates, amino acids, inorganic ions, dipeptides and oligopeptides, metabolic products, lipids and sterols, and heme, to name a few. Pssm-ID: 380565 [Multi-domain] Cd Length: 334 Bit Score: 161.15 E-value: 2.15e-46
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| LivK | COG0683 | ABC-type branched-chain amino acid transport system, periplasmic component [Amino acid ... |
59-360 | 1.87e-27 | ||||||
ABC-type branched-chain amino acid transport system, periplasmic component [Amino acid transport and metabolism]; Pssm-ID: 440447 [Multi-domain] Cd Length: 314 Bit Score: 110.02 E-value: 1.87e-27
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| PRK15404 | PRK15404 | high-affinity branched-chain amino acid ABC transporter substrate-binding protein; |
76-350 | 5.63e-15 | ||||||
high-affinity branched-chain amino acid ABC transporter substrate-binding protein; Pssm-ID: 237959 [Multi-domain] Cd Length: 369 Bit Score: 75.44 E-value: 5.63e-15
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| ANF_receptor | pfam01094 | Receptor family ligand binding region; This family includes extracellular ligand binding ... |
78-354 | 7.54e-13 | ||||||
Receptor family ligand binding region; This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure. Pssm-ID: 460062 [Multi-domain] Cd Length: 347 Bit Score: 68.57 E-value: 7.54e-13
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| Name | Accession | Description | Interval | E-value | ||||||
| PBP1_ABC_LIVBP-like | cd06342 | type 1 periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active ... |
59-351 | 2.15e-46 | ||||||
type 1 periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); This subgroup includes the type 1 periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine). This subgroup also includes a leucine-specific binding protein (or LivK), which is very similar in sequence and structure to leucine-isoleucine-valine binding protein (LIVBP). ABC-type active transport systems are transmembrane proteins that function in the transport of diverse sets of substrates across extra- and intracellular membranes, including carbohydrates, amino acids, inorganic ions, dipeptides and oligopeptides, metabolic products, lipids and sterols, and heme, to name a few. Pssm-ID: 380565 [Multi-domain] Cd Length: 334 Bit Score: 161.15 E-value: 2.15e-46
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| PBP1_ABC_transporter_LIVBP-like | cd06268 | periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the ... |
59-301 | 1.89e-35 | ||||||
periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type 1 periplasmic binding fold protein superfamily; Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type 1 periplasmic binding fold protein superfamily. They are mostly present in archaea and eubacteria, and are primarily involved in scavenging solutes from the environment. ABC-type transporters couple ATP hydrolysis with the uptake and efflux of a wide range of substrates across bacterial membranes, including amino acids, peptides, lipids and sterols, and various drugs. These systems are comprised of transmembrane domains, nucleotide binding domains, and in most bacterial uptake systems, periplasmic binding proteins (PBPs) which transfer the ligand to the extracellular gate of the transmembrane domains. These PBPs bind their substrates selectively and with high affinity. Members of this group include ABC-type Leucine-Isoleucine-Valine-Binding Proteins (LIVBP), which are homologous to the aliphatic amidase transcriptional repressor, AmiC, of Pseudomonas aeruginosa. The uncharacterized periplasmic components of various ABC-type transport systems are included in this group. Pssm-ID: 380492 [Multi-domain] Cd Length: 298 Bit Score: 131.30 E-value: 1.89e-35
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| LivK | COG0683 | ABC-type branched-chain amino acid transport system, periplasmic component [Amino acid ... |
59-360 | 1.87e-27 | ||||||
ABC-type branched-chain amino acid transport system, periplasmic component [Amino acid transport and metabolism]; Pssm-ID: 440447 [Multi-domain] Cd Length: 314 Bit Score: 110.02 E-value: 1.87e-27
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| PBP1_ABC_HAAT-like | cd06344 | type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
60-300 | 1.88e-27 | ||||||
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of hydrophobic amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of hydrophobic amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally. Pssm-ID: 380567 [Multi-domain] Cd Length: 332 Bit Score: 110.39 E-value: 1.88e-27
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| PBP1_ABC_ligand_binding-like | cd06340 | type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
60-304 | 1.26e-24 | ||||||
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, their ligand specificity has not been determined experimentally. Pssm-ID: 380563 [Multi-domain] Cd Length: 352 Bit Score: 103.02 E-value: 1.26e-24
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| PBP1_ABC_HAAT-like | cd06349 | type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
59-356 | 5.03e-23 | ||||||
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally. Pssm-ID: 380572 [Multi-domain] Cd Length: 338 Bit Score: 98.02 E-value: 5.03e-23
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| PBP1_ABC_ligand_binding-like | cd19984 | type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
60-300 | 4.44e-22 | ||||||
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally. Pssm-ID: 380639 [Multi-domain] Cd Length: 296 Bit Score: 94.59 E-value: 4.44e-22
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| PBP1_ABC_LivK_ligand_binding-like | cd06347 | type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
59-340 | 1.54e-20 | ||||||
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally. Pssm-ID: 380570 [Multi-domain] Cd Length: 334 Bit Score: 91.06 E-value: 1.54e-20
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| PBP1_ABC_ligand_binding-like | cd06346 | type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
59-301 | 1.75e-16 | ||||||
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally. Pssm-ID: 380569 [Multi-domain] Cd Length: 314 Bit Score: 79.14 E-value: 1.75e-16
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| PBP1_ABC_ligand_binding-like | cd19982 | type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
60-296 | 1.69e-15 | ||||||
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, their ligand specificity has not been determined experimentally. Pssm-ID: 380637 [Multi-domain] Cd Length: 302 Bit Score: 76.17 E-value: 1.69e-15
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| PRK15404 | PRK15404 | high-affinity branched-chain amino acid ABC transporter substrate-binding protein; |
76-350 | 5.63e-15 | ||||||
high-affinity branched-chain amino acid ABC transporter substrate-binding protein; Pssm-ID: 237959 [Multi-domain] Cd Length: 369 Bit Score: 75.44 E-value: 5.63e-15
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| PBP1_ABC_HAAT-like | cd19985 | type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
59-301 | 1.21e-14 | ||||||
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of hydrophobic amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of hydrophobic amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally. Pssm-ID: 380640 [Multi-domain] Cd Length: 321 Bit Score: 73.85 E-value: 1.21e-14
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| PBP1_ABC_ligand_binding-like | cd06338 | type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
59-351 | 3.01e-14 | ||||||
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT); however, their ligand specificity has not been determined experimentally. Pssm-ID: 380561 [Multi-domain] Cd Length: 347 Bit Score: 73.00 E-value: 3.01e-14
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| PBP1_ABC_transporter_GPCR_C-like | cd04509 | Family C of G-protein coupled receptors and their close homologs, the type 1 ... |
85-228 | 4.06e-13 | ||||||
Family C of G-protein coupled receptors and their close homologs, the type 1 periplasmic-binding proteins of ATP-binding cassette transporter-like systems; This CD includes members of the family C of G-protein coupled receptors and their close homologs, the type 1 periplasmic-binding proteins of ATP-binding cassette transporter-like systems. The family C GPCR includes glutamate/glycine-gated ion channels such as the NMDA receptor, G-protein-coupled receptors, metabotropic glutamate, GABA-B, calcium sensing, pheromone receptors, and atrial natriuretic peptide-guanylate cyclase receptors. The glutamate receptors that form cation-selective ion channels, iGluR, can be classified into three different subgroups according to their binding-affinity for the agonists NMDA (N-methyl-D-asparate), AMPA (alpha-amino-3-dihydro-5-methyl-3-oxo-4-isoxazolepropionic acid), and kainate. L-glutamate is a major neurotransmitter in the brain of vertebrates and acts through either mGluRs or iGluRs. mGluRs subunits possess seven transmembrane segments and a large N-terminal extracellular domain. ABC-type leucine-isoleucine-valine binding protein (LIVBP) is a bacterial periplasmic binding protein that has homology with the amino-terminal domain of the glutamate-receptor ion channels (iGluRs). The extracellular regions of iGluRs are made of two PBP-like domains in tandem, a LIVBP-like domain that constitutes the N terminus (included in this model) followed by a domain related to lysine-arginine-ornithine-binding protein (LAOBP) that belongs to the type 2 periplasmic binding fold protein superfamily. The uncharacterized periplasmic components of various ABC-type transport systems are also included in this family. Pssm-ID: 380490 Cd Length: 306 Bit Score: 69.26 E-value: 4.06e-13
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| ANF_receptor | pfam01094 | Receptor family ligand binding region; This family includes extracellular ligand binding ... |
78-354 | 7.54e-13 | ||||||
Receptor family ligand binding region; This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure. Pssm-ID: 460062 [Multi-domain] Cd Length: 347 Bit Score: 68.57 E-value: 7.54e-13
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| PBP1_ABC_ligand_binding-like | cd19980 | type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
59-236 | 9.80e-13 | ||||||
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally. Pssm-ID: 380635 [Multi-domain] Cd Length: 334 Bit Score: 68.40 E-value: 9.80e-13
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| Peripla_BP_6 | pfam13458 | Periplasmic binding protein; This family includes a diverse range of periplasmic binding ... |
59-304 | 2.41e-11 | ||||||
Periplasmic binding protein; This family includes a diverse range of periplasmic binding proteins. Pssm-ID: 433225 [Multi-domain] Cd Length: 342 Bit Score: 64.22 E-value: 2.41e-11
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| PBP1_ABC_ligand_binding-like | cd06345 | type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
59-294 | 2.85e-11 | ||||||
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally. Pssm-ID: 380568 [Multi-domain] Cd Length: 356 Bit Score: 64.21 E-value: 2.85e-11
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| PBP1_SBP-like | cd19989 | periplasmic substrate-binding domain of active transport proteins; Periplasmic ... |
59-191 | 3.70e-11 | ||||||
periplasmic substrate-binding domain of active transport proteins; Periplasmic substrate-binding domain of active transport proteins found in bacteria and Archaea. Members of this group are initial receptors in the process of active transport across cellular membrane, but their substrate specificities are not known in detail. However, they closely resemble the group of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa. Moreover, this binding domain has high sequence identity to the family of hydrophobic amino acid transporters (HAAT), and thus it may also be involved in transport of amino acids. Pssm-ID: 380644 [Multi-domain] Cd Length: 299 Bit Score: 63.06 E-value: 3.70e-11
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| PBP1_GPCR_family_C-like | cd06350 | ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory ... |
89-240 | 5.83e-11 | ||||||
ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate; categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (m; Ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate and are categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). The metabotropic glutamate receptors (mGluR) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. The mGluRs are coupled to G proteins and are thus distinct from the iGluRs which internally contain ligand-gated ion channels. The mGluR structure is divided into three regions: the extracellular region, the seven-spanning transmembrane region and the cytoplasmic region. The extracellular region is further divided into the ligand-binding domain (LBD) and the cysteine-rich domain. The LBD has sequence similarity to the LIVBP, which is a bacterial periplasmic protein (PBP), as well as to the extracellular region of both iGluR and the gamma-aminobutyric acid (GABA)b receptor. iGluRs are divided into three main subtypes based on pharmacological profile: NMDA, AMPA, and kainate receptors. All family C GPCRs have a large extracellular N terminus that contain a domain with homology to bacterial periplasmic amino acid-binding proteins. Pssm-ID: 380573 Cd Length: 350 Bit Score: 63.08 E-value: 5.83e-11
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| PBP1_ABC_ligand_binding-like | cd06343 | type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
60-300 | 2.24e-10 | ||||||
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however its ligand specificity has not been determined experimentally. Pssm-ID: 380566 [Multi-domain] Cd Length: 355 Bit Score: 61.43 E-value: 2.24e-10
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| PBP1_ABC_HAAT-like | cd19981 | type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
60-300 | 5.79e-10 | ||||||
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally. Pssm-ID: 380636 [Multi-domain] Cd Length: 297 Bit Score: 59.61 E-value: 5.79e-10
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| PBP1_ABC_ligand_binding-like | cd06335 | type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
59-183 | 4.16e-09 | ||||||
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters, such as leucine-isoleucine-valine binding protein (LIVBP); however their ligand specificity has not been determined experimentally. Pssm-ID: 380558 [Multi-domain] Cd Length: 348 Bit Score: 57.23 E-value: 4.16e-09
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| PBP1_ABC_HAAT-like | cd19988 | type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
60-301 | 4.37e-09 | ||||||
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally. Pssm-ID: 380643 [Multi-domain] Cd Length: 302 Bit Score: 56.90 E-value: 4.37e-09
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| PBP1_ABC_HAAT-like | cd19983 | type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
59-164 | 2.59e-08 | ||||||
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of hydrophobic amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of hydrophobic amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally. Pssm-ID: 380638 [Multi-domain] Cd Length: 303 Bit Score: 54.51 E-value: 2.59e-08
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| PBP1_ABC_HAAT-like | cd19986 | type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
60-300 | 3.17e-08 | ||||||
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally. Pssm-ID: 380641 [Multi-domain] Cd Length: 297 Bit Score: 54.17 E-value: 3.17e-08
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| PBP1_As_SBP-like | cd06330 | periplasmic substrate-binding domain of active transport proteins; Periplasmic ... |
59-184 | 7.63e-07 | ||||||
periplasmic substrate-binding domain of active transport proteins; Periplasmic substrate-binding domain of active transport proteins found in bacteria and Archaea that is predicted to be involved in the efflux of toxic compounds. Members of this subgroup include proteins from Herminiimonas arsenicoxydans, which is resistant to arsenic (As) and various heavy metals such as cadmium and zinc. Moreover, they show significant sequence similarity to the cluster of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa. Pssm-ID: 380553 [Multi-domain] Cd Length: 342 Bit Score: 50.25 E-value: 7.63e-07
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| PBP1_GABAb_receptor_plant | cd19990 | periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close ... |
53-188 | 7.30e-06 | ||||||
periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close homologs in other plants; This group includes the ligand-binding domain of Arabidopsis thaliana glutamate receptors, which have sequence similarity with animal ionotropic glutamate receptor and its close homologs in other plants. The ligand-binding domain of GABAb receptors are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA). GABA is the major inhibitory neurotransmitter in the mammalian CNS and, like glutamate and other transmitters, acts via both ligand gated ion channels (GABAa receptors) and G-protein coupled receptors (GABAb receptor or GABAbR). GABAa receptors are members of the ionotropic receptor superfamily which includes alpha-adrenergic and glycine receptors. The GABAb receptor is a member of a receptor superfamily which includes the mGlu receptors. The GABAb receptor is coupled to G alpha-i proteins, and activation causes a decrease in calcium, an increase in potassium membrane conductance, and inhibition of cAMP formation. The response is thus inhibitory and leads to hyperpolarization and decreased neurotransmitter release, for example. Pssm-ID: 380645 [Multi-domain] Cd Length: 373 Bit Score: 47.61 E-value: 7.30e-06
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| PBP1_AmiC-like | cd06331 | type 1 periplasmic components of amide-binding protein (AmiC) and the active transport system ... |
59-122 | 7.09e-04 | ||||||
type 1 periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); This group includes the type 1 periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF), found in bacteria and Archaea. AmiC controls expression of the amidase operon by a ligand-triggered conformational switch. In the absence of ligand or presence of butyramide (repressor), AmiC (the ligand sensor and negative regulator) adopts an open conformation and inhibits the transcription antitermination function of AmiR by direct protein-protein interaction. In the presence of inducing ligands such as acetamide, AmiC adopts a closed conformation which disrupts a silencing AmiC-AmiR complex and the expression of amidase and other genes of the operon is induced. FmdDEF is predicted to be an ATP-dependent transporter and closely resembles the periplasmic binding protein and the two transmembrane proteins present in various hydrophobic amino acid-binding transport systems. Pssm-ID: 380554 [Multi-domain] Cd Length: 333 Bit Score: 41.05 E-value: 7.09e-04
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| PBP1_SBP-like | cd06328 | periplasmic substrate-binding domain of active transport proteins (substrate binding proteins ... |
59-185 | 7.30e-04 | ||||||
periplasmic substrate-binding domain of active transport proteins (substrate binding proteins or SBPs); Periplasmic substrate-binding domain of active transport proteins found in gram-negative and gram-positive bacteria. Members of this group are initial receptors in the process of active transport across cellular membrane, but their substrate specificities are not known in detail. However, they closely resemble the group of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa. Moreover, this binding domain has high sequence identity to the family of hydrophobic amino acid transporters (HAAT), and thus it may also be involved in transport of amino acids. Pssm-ID: 380551 [Multi-domain] Cd Length: 336 Bit Score: 41.13 E-value: 7.30e-04
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| PBP1_ABC_RPA1789-like | cd06333 | type 1 periplasmic binding-protein component (CouP) of an ABC system (CouPSTU; RPA1789, ... |
59-262 | 1.30e-03 | ||||||
type 1 periplasmic binding-protein component (CouP) of an ABC system (CouPSTU; RPA1789, RPA1791-1793), involved in active transport of lignin-derived aromatic substrates, and its close homologs; This group includes RPA1789 (CouP) from Rhodopseudomonas palustris and its close homologs in other bacteria. RPA1789 (CouP) is the periplasmic binding-protein component of an ABC system (CouPSTU; RPA1789, RPA1791-1793) that is involved in the active transport of lignin-derived aromatic substrates. Members of this group has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP). Pssm-ID: 380556 [Multi-domain] Cd Length: 342 Bit Score: 40.22 E-value: 1.30e-03
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| PBP1_aromatic_compounds-like | cd06332 | type 1 periplasmic binding proteins of active transport systems predicted to be involved in ... |
59-304 | 1.80e-03 | ||||||
type 1 periplasmic binding proteins of active transport systems predicted to be involved in transport of aromatic compounds such as 2-nitrobenzoic acid and alkylbenzenes; This group includes the type 1 periplasmic binding proteins of active transport systems that are predicted to be involved in transport of aromatic compounds such as 2-nitrobenzoic acid and alkylbenzenes; their substrate specificities are not well characterized, however. Members also exhibit close similarity to active transport systems for short chain amides and/or urea found in bacteria and archaea. Pssm-ID: 380555 [Multi-domain] Cd Length: 336 Bit Score: 39.89 E-value: 1.80e-03
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| PBP1_pheromone_receptor | cd06365 | Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within ... |
89-229 | 7.28e-03 | ||||||
Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily, which also includes the metabotropic glutamate receptor, the GABAb receptor, the calcium-sensing receptor (CaSR), the T1R taste receptor, and a small group of uncharacterized orphan receptors. Pssm-ID: 380588 [Multi-domain] Cd Length: 464 Bit Score: 38.01 E-value: 7.28e-03
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