|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
22-396 |
9.50e-72 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 230.19 E-value: 9.50e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 22 LMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFAITLVCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMF 101
Cdd:cd06173 3 LLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 102 ILATIFGPSLLFIYVSAALLSICASFYSVALTSSIPSLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFFSIKSFFL 181
Cdd:cd06173 83 LLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 182 LNSITFFLAVILQLFIVFDLyKKEVAESKERFLTSIKEGFSYVKRQHEIYGLMKIALWVNFFACGLTVALPYIIVHTLHL 261
Cdd:cd06173 163 INALSFLLSALLLLFIRRPP-PAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 262 SSKQLGTVEGMLAVGMLMGAIALSVRKEVKNPFRSIYTGLFLFAGLSLCTVFpllvtipkVASFIYYIAFMMLTGISIMI 341
Cdd:cd06173 242 GAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL--------SPSLWLLLAALFLLGLAGGL 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1005591338 342 VNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDMLPTSIVMMT 396
Cdd:cd06173 314 FNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLL 368
|
|
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
22-388 |
1.06e-47 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 167.11 E-value: 1.06e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 22 LMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFAITLVCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMF 101
Cdd:TIGR00900 3 LLFAAQLISLIGTAITQVALPLYVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMIGADLIRAVLVAVLP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 102 ILATIFGPSLLFIYVSAALLSICASFYSVALTSSIPSLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFFSIKSFFL 181
Cdd:TIGR00900 83 FVALLGGLNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWAIW 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 182 LNSITFFLAVILQLFI-VFDLYKKEVAESKERFLTSIKEGFSYVKRQHEIYGLMKIALWVNF-FACGLTVALPYIIVHTL 259
Cdd:TIGR00900 163 VDAVGFAISALLIVSVrIPELAASEIQALSNAVLRDTREGIKFVLKNPLLRTLLLLALLFNLvFAPAIVALFPYVQSKYL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 260 HLSSKQLGTVEGMLAVGMLMGAIALSV-RKEVKNPFrsIYTGLFLFAGLSLCTVFPLLVTIPkvasFIYYIAFMMltGIS 338
Cdd:TIGR00900 243 GRGSTHYGWVLAAFGLGALLGALLLGLlGRYFKRMA--LMTGAIFVIGLAILVVGLTPPNFP----LFLVLWFAI--GVG 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1005591338 339 IMIVNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDML 388
Cdd:TIGR00900 315 YGPINVPQGTLLQRRVPAELLGRVFGAQFSLSHAAWPLGLILAGPLADHL 364
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
18-376 |
1.72e-24 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 103.52 E-value: 1.72e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 18 RNIILMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFAITLVCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTM 97
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 98 LIMFilatiFGPSLLFIYVSAALLSICASFYSVALTSSIPSLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFFSIK 177
Cdd:COG2814 90 LLCA-----LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 178 SFFLLNSITFFLAVILQLFIvfdlykkeVAESKERFLTSIKEGFSYVKRQHEIYGLMKIALWVNFFACGLTVALPYIIVH 257
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRL--------LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 258 TLHLSSKQLGTVEGMLAVGMLMGAIALSVRKEVKNPFRSIYTGLFLFAGLSLCTVFpllvtipkVASFIYYIAFMMLTGI 337
Cdd:COG2814 237 VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL--------AGSLWLLLLALFLLGF 308
|
330 340 350
....*....|....*....|....*....|....*....
gi 1005591338 338 SIMIVNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAPL 376
Cdd:COG2814 309 GFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
29-386 |
2.12e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 86.09 E-value: 2.12e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 29 TSLLGAGIYTFAMGLYVLKTTGSGMGFAITLVCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMfilatIFG 108
Cdd:cd17325 7 LDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF-----AFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 109 PSLLFIYVSAALLSICASFYSVALTSSIPSLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFFSIKSFFLLNSITFF 188
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 189 LAVILQLFIVFDlyKKEVAESKERFLTSIKEGFSYVKRQHEIYGLMKIALWVNFFACGLTVALPYIIVHTLHLSSKQLGT 268
Cdd:cd17325 162 LALVLALLLLPE--PRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 269 VEGMLAVGMLMGAIALSVRKEVKNPFRSIYTGLFLFAGlslctvfpLLVTIPKVASFIYYIAFMMLTGISIMIVNIPMQV 348
Cdd:cd17325 240 LFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV--------ALLLLPLATSFWLLLLLLALLGLGLGLVFPATLA 311
|
330 340 350
....*....|....*....|....*....|....*...
gi 1005591338 349 HMQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLD 386
Cdd:cd17325 312 LLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD 349
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
23-378 |
3.80e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 79.00 E-value: 3.80e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 23 MMIGKMTSLLGAGIYTFAMGLYVLKTTG-SGMGFAITLVCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMF 101
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGiSPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 102 ilatiFGPSLLFIYVSAALLSICASFYSVALTSSIPSLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFFSIKSFFL 181
Cdd:pfam07690 81 -----FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 182 LNSITFFLAVILqLFIVFDLYKKEVAESKERFLTSIKEGFSYVKRQHEIYGLmkIALWVNFFACGLTVALPYIIVHTLHL 261
Cdd:pfam07690 156 ILAILSLLAAVL-LLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLL--LALLLFGFAFFGLLTYLPLYQEVLGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 262 SSKQLGTVEGMLAVGMLMGAIALSVRKEVKNPFRSIYTGLFLFAGLSLCTVFPLLVTipkvaSFIYYIAFMMLTGISIMI 341
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTL-----SSLWLLLALLLLGFGFGL 307
|
330 340 350
....*....|....*....|....*....|....*..
gi 1005591338 342 VNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAPLGM 378
Cdd:pfam07690 308 VFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
20-395 |
9.38e-15 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 75.34 E-value: 9.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 20 IILMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFA-ITLVCGSLPRMICGPIAGAVADRVNRKWLVigtdLLSSLTML 98
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVgLVLALSAVAGIVASLIGGRLADRFGRKPVM----LAGLLLRA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 99 IMFILATIFGpSLLFIYVSAALLSICASFYSVALTSSIPSLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGfFSIKS 178
Cdd:cd17329 77 LGFALLGFAH-SPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 179 FFLLNSITFFLAVIlqlfIVFDLYKKEVAESKERFLTSIKEGFSYVKRQHEIYGLMKIALWVNFFACGLTVALPYIIVHT 258
Cdd:cd17329 155 LFLAAAVLFLLAAL----VLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 259 LHLSSKQLGTVEGMLAVGMLMGAIALSVRKEVKNPFRSIYTGLFL----FAGLSLCTVFPLLVtipkVASFIYYIAFMML 334
Cdd:cd17329 231 LGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLfaigFAVLAFANTLAVLI----LAMIVLTLGEMLV 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1005591338 335 TGISIMIVNipmqvhmqKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDMLPTSIVMM 395
Cdd:cd17329 307 FPAVQTLVA--------ALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWL 359
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
25-320 |
3.82e-14 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 74.02 E-value: 3.82e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 25 IGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFAITLVCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMFILA 104
Cdd:pfam05977 17 IASLASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALVSTLLTLLA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 105 TI--FGPSLLFIyvSAALLSICASFYSVALTSSIPSLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFFSIKSFFLL 182
Cdd:pfam05977 97 GLglLSPWLLLG--LTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAFGPAFTFAL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 183 NSITFF--LAVILQlfivfdlYKKEVAES---KERFLTSIKEGFSYVKRQHEIYGLMKIALWVNFFACGLTVALPYIIVH 257
Cdd:pfam05977 175 NALSYFavIAALWR-------WKRAAPASplpRERIFGAVRAGLRFTAMSRELRSVLVRAFAFGLSASAVWALLPLVARD 247
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1005591338 258 TLHLSSKQLGTVEGMLAVGMLMGAIALSVRKEVKNPFRSIYTGLFLFAG--LSLCTVFPLLVTIP 320
Cdd:pfam05977 248 LLDGDAIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALvlLSLALAPNLWLAIP 312
|
|
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
25-391 |
1.04e-11 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 66.16 E-value: 1.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 25 IGKMTSLLGAGIYTFAMGLYVLKTTGSGM--GFAITLVCGSlprMICGPIAGAV-ADRVNRKWLVIGTDLLSSLTMLIMF 101
Cdd:PRK10489 24 IARFISIFGLGLLGVAVPVQIQMMTGSTLqvGLSVTLTGGA---MFIGLMVGGVlADRYDRKKLILLARGTCGLGFIGLA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 102 ILATIFGPSLLFIYVSAALLSICASFYSVALTSSIPSLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFFSIKSFFL 181
Cdd:PRK10489 101 LNAFLPEPSLLAIYLLGLWDGFFGSLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPALGGLLIAAGGVAWNYG 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 182 LNSITFFLAVILqlfiVFDLYKKEVAESK-ERFLTSIKEGFSYVKRQHEIYGLMKIALWVNFFAcGLTVALPYIIVHTLH 260
Cdd:PRK10489 181 LAAAGTFITLLP----LLRLPALPPPPQPrEHPLRSLLAGFRFLLASPVVGGIALLGGLLTMAS-AVRVLYPALADEVWQ 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 261 LSSKQLGTVEGMLAVGMLMGAIALSVRKEVKNPfrsiytGLFLFagLSLCTVFPLLVTIPKVASFIYYIAFMMLTGISIM 340
Cdd:PRK10489 256 MGAAQIGLLYAAVPLGAALGALTSGWLAHSARP------GLLML--LSTLGSFLAVGLFGLMPMWILAVLCLALFGYLSA 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1005591338 341 IVNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDMLPTS 391
Cdd:PRK10489 328 ISSLLQYTLLQTQTPDEMLGRINGLWTAQNVTGDAIGAALLGGLGAMMTPV 378
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
28-387 |
1.45e-11 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 65.53 E-value: 1.45e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 28 MTSLLGAGIYTFAMGLYVLKTTGSGMGFAITLVCGSLPRMICGPIAGAVADRVNRKWLvigtdLLSSLTMLIMFILATIF 107
Cdd:cd06174 6 FLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPV-----LLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 108 GPSLLFIYVSAALLSICASFYSVALTSSIPSLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFFSI--KSFFLLNSI 185
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFgwRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 186 TFFLAVILQLFIVFDLYKKEVAESKERFLTSIKEGFSYVKRQHEIYGLMKIALWVNFFACGLTVALPYIIVHTLHLSSKQ 265
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 266 LGTVEGMLAVGMLMGAIALSVRkeVKNPFRSIYTGLFLFAGLSLCTVFPLLVTipkvaSFIYYIAFMMLTGISIMIVNIP 345
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLL--SDRLIGRKPLLLIGLLLMALGLALLLLAP-----SLLLLLLLLLLLGFGLGGLLPL 313
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1005591338 346 MQVHMQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDM 387
Cdd:cd06174 314 SFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAA 355
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
9-198 |
6.16e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 63.36 E-value: 6.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 9 HDTRMKIATRNIILMMIGkmTSLLGAGIYTFAMGLYVLKTTGSGMGFAItlvcGSLPRMICGPIAGAVADRVNRKWLVIG 88
Cdd:cd17325 197 RDRRLLALFLAIFVLAFA--FGALEPFLPLYAAELGGLSPAQIGLLFGA----QGLASALSQPPAGKLSDRIGRKPLILI 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 89 TDLLSSLTMLIMfilatIFGPSLLFIYVSAALLSICASFYSVALTSSIPSLVDEGRIQKASALNQTAASLSNILGPIIGG 168
Cdd:cd17325 271 GLLLSAVALLLL-----PLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGG 345
|
170 180 190
....*....|....*....|....*....|
gi 1005591338 169 VVFGFFSIKSFFLLNSITFFLAVILQLFIV 198
Cdd:cd17325 346 FLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
67-396 |
5.29e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 60.65 E-value: 5.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 67 MICGPIAGAVADRVNRKWLVIGTDLLSSLtmlimFILATIFGPSLLFIYVSAALLSICASFYSVALTSSIPSLVDEGRIQ 146
Cdd:COG2271 59 ALGQIPAGLLADRFGRRRVLAIGLLLWGL-----ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERG 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 147 KASALNQTAASLSNILGPIIGGVVFGFFSIKSFFLLNSITFFLAVILQLFIVFdlykkevaeskerfltsikegfsyvkr 226
Cdd:COG2271 134 RALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRFWLLA--------------------------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 227 qheiygLMKIALWVNFFacGLTVALPYIIVHTLHLSSKQLGTVEGMLAVGMLMGAIA---LSVRkeVKNPFRSIYTGLFL 303
Cdd:COG2271 187 ------LAYFLVYFALY--GFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLggwLSDR--LGRRRKLVLAIGLL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 304 FAGLSlctvfplLVTIPKVASFIYYIAFMMLTGISIMIVNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGL 383
Cdd:COG2271 257 LAALA-------LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGY 329
|
330
....*....|...
gi 1005591338 384 LLDMLPTSIVMMT 396
Cdd:COG2271 330 LLDATGYQAAFLL 342
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
8-304 |
4.40e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 57.13 E-value: 4.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 8 QHDTRMKIATRNIILMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFAITLVCGSLPRMICGPIAGAVADRVNRKWLVI 87
Cdd:COG0477 4 TDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 88 GTDLLSSLTMLIMFILatifgPSLLFIYVSAALLSICASFYSVALTSSIPSLVDEGRIQKASALNQTAASLSNILGPIIG 167
Cdd:COG0477 84 IGLLLFGLASLLCGLA-----PSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 168 GVVFGFFSIKSFFLLNSITFFLAVILQLFIVFDLYKKEVAESKERFLTSIKEGFSYVKRQHEIYGLMKIALWVNFFACGL 247
Cdd:COG0477 159 GLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAA 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1005591338 248 TVALPYIIVHTLHLSSKQLGTVEGMLAVGMLMGAIALSVRKEVKNPFRSIYTGLFLF 304
Cdd:COG0477 239 LLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
10-344 |
7.60e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.22 E-value: 7.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 10 DTRMKIATRNIILMMIGKM-TSLLGAGIYTFAMGLYV----LKTTGSGMGFAITLVCGslprMICGPIAGAVADRVNRKW 84
Cdd:COG2211 2 AAKKKLSLKEKLAYGLGDLgLNLAFGLLSAYLLYFYTdvlgLSAALVGLILLVARLWD----AITDPLIGALSDRTRTRW 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 85 ------LVIGTdLLSSLTMLIMFiLATIFGPSLLFIYVSAA--LLSICASFYSVALTSSIPSLVDEGRIQ-KASALNQTA 155
Cdd:COG2211 78 grrrpwILIGA-IPLALSFVLLF-TAPDLSPTGKLIYALVTylLLGLAYTLVNIPYSALGAELTPDYEERtRLSSWRFAF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 156 ASLSNILGPIIGGVVFGFFS---IKSFFLLNSITFFLAVILQLFIVFDLYKKEVAESKErflTSIKEGFSYVKRQHE--I 230
Cdd:COG2211 156 AGLGGLLASVLPPPLVAAFGgdaALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEK---VSLKESLKALLKNRPflL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 231 YGLMKIALWVNFFAcgLTVALPYIIVHTLHLSSKQLGTVEGMLAVGMLMGAI---ALSVRKEVKNPFRsiytglflfAGL 307
Cdd:COG2211 233 LLLAYLLFFLALAL--VAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPlwpRLAKRFGKKKAFI---------IGL 301
|
330 340 350
....*....|....*....|....*....|....*..
gi 1005591338 308 SLCTVFPLLVTIPKVASFIYYIAFMMLTGISIMIVNI 344
Cdd:COG2211 302 LLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILV 338
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
56-393 |
6.91e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 54.11 E-value: 6.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 56 AITLVCGSLPRMICGPIAGAVADRVNRKWLvigtdLLSSLTMLIMFILATIFGPSLLFIYVSAALLSICASFYSVALTSS 135
Cdd:cd17474 37 GLLITAFTLPAAVLMPVAGVLADRFGRKKV-----LLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 136 IPSLVDEGRIQKASALNQTAASLSNILGPIIGGVVfGFFSIKSFFLLNSITFFLAVILQLFIVfdlykKEVAESKERFLT 215
Cdd:cd17474 112 IGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL-AAISWRYPFFLLAALIPVAFLAILFLL-----PEPKEKAKSSSA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 216 SIKEGFSYVKRQHEIYGLMKIALWVNFFACGLTVALPYIIVHTLHLSSKQLGTVEGMLAVGMLMGAIALSVRKEVKNPFR 295
Cdd:cd17474 186 TKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGAR 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 296 SIYTGLFLFAGLSLCtVFPLLVTIPKVasfiyyIAFMMLTGISIMIVNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAP 375
Cdd:cd17474 266 RILVIGLLLYALSLL-LLGFVPSLALL------LIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQA 338
|
330
....*....|....*...
gi 1005591338 376 LGMIVYGLLLDMLPTSIV 393
Cdd:cd17474 339 VGPLLFGLLLEIFGLSAP 356
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
67-197 |
7.09e-08 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 54.04 E-value: 7.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 67 MICGPIAGAVADRVNRKWLVI--GTdLLSSLTMLIMFILATIFGPSLLFIYVSAALLSICASFYsVALTSSIPSLVDEGR 144
Cdd:cd17337 258 IFFNLIFGILGDKIGWRRTVRwfGG-VGCAISTLLFYYVPQLFGHNYWAALIAAILFGIGLAGF-VPLSALMPSLAPEHK 335
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1005591338 145 IQKASALNqTAASLSNILGPIIGGVVFGFFSIKSFFLLNSITFFLAVILQLFI 197
Cdd:cd17337 336 GAAMSILN-LGAGLSNFVGPAIVTLFLGSFGAGGVVWIFAGLYLLSAVLTLFL 387
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
73-362 |
2.05e-07 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 53.39 E-value: 2.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 73 AGAVADRVNRKWLVIGTDLLSSLTMLIMfILATIFGPsLLFIYVSAALLSICASFYSVALTSSIPSLVDEGRIQKASALN 152
Cdd:PRK08633 67 AGFLADKFSKNRVIRIVKLFEVGLTLLI-VLAYYLGW-FWLAFAVTFLLGAQSAIYSPAKYGIIPELVGKENLSRANGLL 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 153 QTAASLSNILGPIIGGVVF-GFFSIKSFFLLNSITFFLAVIL-----QLFIVFDL------YKKEVAESKERFLTSIKEG 220
Cdd:PRK08633 145 EAFTIVAILAGTALFSFLFeSVNGNTPSEILGRIAPAGLVLLavavlGLIFAYRLpkvpaaAPEVFDKKKYLFPKLLWRN 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 221 FSYVKRQHEIYgLMKIAL-WVNFFACGLTVALPYIIVHTLHLS-SKQLGTVEGMLAVGMLMGAI---ALSVRKevknpfr 295
Cdd:PRK08633 225 LKLLRSDRVLW-LAIIGLsYFWFISQLAQANFPAYAKEVLGLDnTFQVQYLLAASAIGIGIGSLlagRLSGRH------- 296
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1005591338 296 sIYTGLFLF--AGLSLCTVFpllvtIPKVASFIYYIAFMMLTGISIMIVNIPMQVHMQKTTDPSYLGRV 362
Cdd:PRK08633 297 -IELGLVPLgaLGLALSLFL-----LPTAPSLASVLVLFFLFGFSAGLFIVPLNALIQFRAPEKELGKV 359
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
67-337 |
2.75e-07 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 52.22 E-value: 2.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 67 MICGPIAGAVADRVN------RKWLVIGTDLLSSLTMLIMFILATIFGPSLLFIYVSAALLSICASFYSVALTSSIPSLV 140
Cdd:cd17332 49 AINDPLMGYLIDRTRsrwgrfRPWLLWGAIPLALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELT 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 141 DEGRIQ-KASALNQTAASLSNILGPIIGGVVFGFFS----IKSFFLLNSITFFLAVILQLFIVFDLYKKEVAESKERFLT 215
Cdd:cd17332 129 DDPEERtSLTSWRMFFATIGGLLVTVLPPPLVAYFGggnaSRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKL 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 216 SIKEGFSYVK--RQHEIYGLMKIALWVNFFAcgLTVALPYIIVHTLHLSSKQLGTVEGMLAVGMLMGAIALSVRKEV-KN 292
Cdd:cd17332 209 PLLKSLKALLknRPFLILLLAYLLYFLAFNI--VNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFgKK 286
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1005591338 293 PFRSIYTGLFLFAGLSLCTVFPLLVTIPKVASFIYYIAFMMLTGI 337
Cdd:cd17332 287 KAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLL 331
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
32-197 |
4.71e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 51.44 E-value: 4.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 32 LGAGIYTFAMGLYVLKTTGSG--MGFAITLVcgSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMfilatIFGP 109
Cdd:cd17489 10 LSFYLLLPVLPLYAHDLGGSEavAGLVVGLF--TLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLY-----LLAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 110 SLLFIYVSAALLSICASFYSVALTSSIPSLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFFSIKSFFLLNSITFFL 189
Cdd:cd17489 83 SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALL 162
|
....*...
gi 1005591338 190 AVILQLFI 197
Cdd:cd17489 163 ALLLVFLV 170
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
67-348 |
1.11e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 50.24 E-value: 1.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 67 MICGPIAGAVADRVNRKWLvigtdLLSSLTMLIMFILATIFGPSLLFIYVSAALLSICASFYSVALTSSIPSLVDEGRIQ 146
Cdd:cd17324 48 ALGALLLGPLSDRIERRRL-----LLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRG 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 147 KASALNQTAASLSNILGPIIGGVVFGFFSIKSFFLLNSITFFLAVILQLFIVfdlykkEVAESKERFLTSIKEGFSYVKR 226
Cdd:cd17324 123 RAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLL------PSLPPKKPGSLGLLSSLLLLLR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 227 QHEIYGLMKIALWVNFFACGLTVALPYIIVHTLHLSSKQLGTVEGMLAVGMLMGAIaLSVRKEVKNPFRSIYTGLFLFAG 306
Cdd:cd17324 197 NPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSP-LAGRLADRGGRRALLIALLLLAA 275
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1005591338 307 LSLCtvFPLLVTIPKVAsfiyyIAFMMLTGISIMIVNIPMQV 348
Cdd:cd17324 276 ALLL--LTLLGPSPLLL-----LVGLVLWGLGFFAAHSALQT 310
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
51-287 |
1.64e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 49.96 E-value: 1.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 51 SGMGFAITLvcgsLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMFILATIFgpSLLFIyvsAALLSICASFYSV 130
Cdd:cd17391 38 SGLAFSSTF----LVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVW--QLLIL---RLLQGVFSGYVPN 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 131 ALTSsIPSLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFFSIKSFFLLNSITFFLAVILQLFIVFDLYKKEVAESK 210
Cdd:cd17391 109 ATAL-IASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEDFKPVEKKKM 187
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1005591338 211 ERFltsiKEGFSYVKRQHEIYGLMkIALWVNFFACGLTVALPYIIVHTLHLSSKQLGTVEGMLAVGMLMGAIALSVR 287
Cdd:cd17391 188 VST----KEVWNSVPNPSLLISLF-VTTFIIQLANQSIEPILTLYIRQLMGDASNLAFISGLVFSATGVSSLLSAPR 259
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
67-366 |
1.14e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.18 E-value: 1.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 67 MICGPIAGAVADRVNRKWLVIGTDLLSSLtmlimFILATIFGPSLLFIYVSAALLSICASFYSVALTSSIPSLVDEGRIQ 146
Cdd:cd17473 49 ALFAPLAGWLADRFGRKRLLIAGLLLYGI-----GGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 147 KASALNQTAASLSNILGPIIGGVVfGFFSIKSFFLLnsitFFLAVILQLFIVFDLYKKEVAESKERFLTSIKEGFSYVKR 226
Cdd:cd17473 124 KMLGLQSAAMSLGGVVFLLLGGAL-AEIGWRAPFLV----YLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKR 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 227 QHEIYGLMKIALWVNFfacGLTVALPYIIVHTLHLSSKQLGTVegmLAVGMLMGAI-ALSVRKEVKN-PFRSIYTGLFLF 304
Cdd:cd17473 199 VLPIYFLAFLAMLLFY---VIPIQLPFLLQERGGGSAALIGLA---LAIASLAGAIgALLFGRLKRRlGKRRLLAIGFAL 272
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1005591338 305 AGLSlctvfplLVTIPKVASFIYYIAFMMLTGISIMIVnIPMQVHM-QKTTDPSYLGRVFGLL 366
Cdd:cd17473 273 MALG-------FLLLALASGLWVVLLGAILAGLGFGLL-LPTLNSWaMSLVPPELRGRAMGIV 327
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
18-197 |
1.46e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 46.80 E-value: 1.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 18 RNIILMMIGkmTSLLGAGIYTFAMGLYVLKTTGSGMGF-------AITLVCGSLPRMICGPIAGAVADRVNRKWLVIgtd 90
Cdd:cd17504 177 RNVLLANIT--ALLAGFGMFMVFQLLPQLLQLPTPTGFglgiteaGLLLLPGALVMLIAGPLAGRLIARVGPRRVLL--- 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 91 lLSSLTMLIMFILATIFGPSLLFIYVSAALLSICASFYSVALTSSIPSLVDEGRIQKASALNQTAASLSNILGPIIGGVV 170
Cdd:cd17504 252 -IGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1005591338 171 FGFFSIKSF-------------FLLNSITFFLAVILQLFI 197
Cdd:cd17504 331 LTTYTVSITsggvptegayvlaFLIGAALALAALLLSLLI 370
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
52-387 |
1.84e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 46.41 E-value: 1.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 52 GMGFAITLVCGSLPRmicgPIAGAVADRVNRKWLVIGTDLLSSLTMLIMFilatiFGPSLLFIYVSAALLSICASFYSVA 131
Cdd:COG2223 43 GLLFAIPVLVGALLR----IPLGFLVDRFGPRRVLLIGLLLLGIGLLLLA-----LAVSYWLLLLLGLLLGIGGGGSFAV 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 132 LTSSIPSLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFFSIKSFFLLNSITFFLAVILQLFIVFDLYKKEVAESKE 211
Cdd:COG2223 114 GIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKA 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 212 RFLTSIKegfsyVKRQHEIYGLMkIALWVNFFA-CGLTVALPYIIVHTLHLSSKQLGTVEGMLAVGMLMGAI---ALSVR 287
Cdd:COG2223 194 SLRDQLE-----ALRDPRFWLLS-LLYFGTFGSfIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPlggWLSDR 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 288 kevknpFRSIYTGLFLFAGLSLCTVFPLLVTipkvASFIYYIAFMMLTGISIMIVNIPMQVHMQKTTDPSYLGRVFGLLE 367
Cdd:COG2223 268 ------IGGRRVLLIVFALMALGLLLLALAL----GSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVG 337
|
330 340
....*....|....*....|
gi 1005591338 368 TIATAIAPLGMIVYGLLLDM 387
Cdd:COG2223 338 AAGGLGGFLGPLLFGALLDA 357
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
38-203 |
2.64e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.02 E-value: 2.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 38 TFAMGLYVLKTTGSGMGFAITLVCGslprMICGPIAGAVADRVNRKWLVIgtdLLSSLTMLIMFILATIFGPSLLFIYVS 117
Cdd:COG2271 205 TYLVEVRGLSLAQAGLLLSLPFLAG----IVGSLLGGWLSDRLGRRRKLV---LAIGLLLAALALLLLALLPSPALAIAL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 118 AALLSICASFYSVALTSSIPSLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFFSIKSFFLLNSITFFLAVILQLFI 197
Cdd:COG2271 278 LFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLL 357
|
....*.
gi 1005591338 198 VFDLYK 203
Cdd:COG2271 358 LRETRK 363
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
34-198 |
3.25e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 45.66 E-value: 3.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 34 AGIYTFaMGLYVLKTTGSGMGFAITLVCGSLprMICGPIAGAVADRVNRKWLVIgtdllSSLTMLIMFILATIFGPSLLF 113
Cdd:cd17489 211 GAISTF-LPLYAAERGISNAGLFFTVYAIAL--LLSRPFSGKLSDRKGPKTVII-----PGLLLLALGLLLLSFAGSPWM 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 114 IYVSAALLSICASFYSVALTSSIPSLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFFSIKSFFLLNSITFFLAVIL 193
Cdd:cd17489 283 LLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
|
....*
gi 1005591338 194 QLFIV 198
Cdd:cd17489 363 YIFLL 367
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
72-339 |
6.55e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 44.87 E-value: 6.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 72 IAGAVADRVNRKwlvigTDLLSSLTMLIMFILATIFGPSLLFIYVSAALLSICASFYSVALTSSIPSLVDEGRIQKASAL 151
Cdd:cd17320 53 LYGPLSDRFGRR-----PVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 152 NQTAASLSNILGPIIGGVVFGFFSIKSFFLlnsITFFLAVILQLFIVFDLYKKEVAESKERFLTSIKEGFSYVKRQHEI- 230
Cdd:cd17320 128 LMMILAIAPALAPLLGGLLLLFFGWRAIFV---FLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFl 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 231 -YGLMKIALWVNFFACGltVALPYIIVHTLHLSSKQLGTVEGMLAVGMLMGAIALSVRKEVKNPFRSIYTGLFLFAglsL 309
Cdd:cd17320 205 gYALALGLSFAGLFAYL--AAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLL---A 279
|
250 260 270
....*....|....*....|....*....|
gi 1005591338 310 CTVFPLLVTIPKVASFIYYIAFMMLTGISI 339
Cdd:cd17320 280 AALVLLLAALLGGLSLWPLVAPLFLIFFGF 309
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
20-198 |
6.69e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 44.95 E-value: 6.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 20 IILMMIGKMTSLLGAGIYTFAMGLYVLKTTG--------SGMGFAITlvcgSLPRMICGPIAGAVADRVNRKWLVIGTDL 91
Cdd:cd17391 203 LISLFVTTFIIQLANQSIEPILTLYIRQLMGdasnlafiSGLVFSAT----GVSSLLSAPRLGKLGDRIGHHRILLGALL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 92 LSSLtmlIMFILATIFGPSLLFIYVSAALLSICASFYSValTSSIPSLVDEGRIQKASALNQTAASLSNILGPIIGGVVF 171
Cdd:cd17391 279 ASAL---LYIPQAFVQTPWQLGILRFLLGLATGGLLPAI--NSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIA 353
|
170 180
....*....|....*....|....*..
gi 1005591338 172 GFFSIKSFFLLNSITFFLAVILQLFIV 198
Cdd:cd17391 354 AHFGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
15-174 |
8.26e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.47 E-value: 8.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 15 IATRNIILMMIGKMTSLLGAGIYTFAMGLYVLKTTG-SGMGFAITLVCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLS 93
Cdd:cd17321 165 LLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGySPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLT 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 94 SLTMLIMFILATIFGPSLLFIYVsaALLSICASFYSVALTSSIPSLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGF 173
Cdd:cd17321 245 AVGLLLLALLGADSSVWLLLPGL--VLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTA 322
|
.
gi 1005591338 174 F 174
Cdd:cd17321 323 G 323
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
71-396 |
8.33e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.47 E-value: 8.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 71 PIAGAVADRVNRKWLVIGTDLLSSLTMLIMFilatiFGPSLLFIYVSAALLSICASFYSVAlTSSIPSLVDEGRIQKASA 150
Cdd:cd17478 49 PLFGYLADRKPRRYLLPLGPLLTGLGLSLLG-----FAPNYWLLLLLVALAGIGSAAFHPE-GARLASQAAGGRRGLAMS 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 151 LNQTAASLSNILGPIIGGVVFGFFSIKSFFLLNSITfFLAVILQLFIVFDLYKKEVAESKErfltSIKEGFSYVKRQHEI 230
Cdd:cd17478 123 IFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIP-GLAVALLLLRLRPLKKPEAKKAAA----KSSARSTLKGVWRAL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 231 YGLMKIALWVNFFACGLTVALPYIIVHtlHLSSKQLGTVegMLAVGMLMGAIA------LSVRKEVKNPFRSIYTGLFLF 304
Cdd:cd17478 198 LLLLIIVFLRSWVLSSLTTFLPFYLVQ--RGYSLVFAGL--LLSLFLFAGAIGtliggpLSDRFGRRRVIIASLLLAAPF 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 305 AGLSLctvfpllvtipkVASFIYYIAFMMLTGISIMiVNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLL 384
Cdd:cd17478 274 LLLFL------------LTPGIWSYILLVLAGFLLF-ASFPVTVVLAQELLPGNVGLASGLMMGLSFGLGGIGAPVLGAL 340
|
330
....*....|..
gi 1005591338 385 LDMLPTSIVMMT 396
Cdd:cd17478 341 ADAFGLESVLLI 352
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
71-394 |
8.94e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.47 E-value: 8.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 71 PIAGAVADRVNRKWLVIGTDLLSSLTMLIMFilatiFGPSLLFIYVSAALLSICASFYSVALTSSIPSLVDEGRIQKASA 150
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCA-----LAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 151 LNQTAASLSNILGPIIGGVVFGFFSIKSFFLLNSITFFLAVILqlfivfdlykkevaeSKERFLTSIkegfsyvkrqhei 230
Cdd:cd17321 124 LWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL---------------ARTFSGAVL------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 231 yglmkIALWVNFFACGLTVALPYIIVHTLHLSSKQLGTVEGMLAVGMLMGAIaLSVRKEVKNPFRSIYTGLFLFAGLSLC 310
Cdd:cd17321 176 -----AAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAP-LAGRLADRFGPRLVLVAGLLLTAVGLL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 311 tvfpLLVTIPKVASFIYYIAFMMLTGISIMIVNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDMLPT 390
Cdd:cd17321 250 ----LLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLS 325
|
....
gi 1005591338 391 SIVM 394
Cdd:cd17321 326 ANLG 329
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
91-193 |
1.37e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 43.72 E-value: 1.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 91 LLSSLTMLIMFILaTIFGPSLLFIYVSAALLSICASFYSVALTSSIPSLVDEGRIQKASALNQTAASLSNILGPIIGGVV 170
Cdd:cd17330 245 RLGLLLAIIGLLL-LPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPL 323
|
90 100
....*....|....*....|...
gi 1005591338 171 FGFFSIKSFFLLNSITFFLAVIL 193
Cdd:cd17330 324 YSFLGPGVPFLLAAGLLLIALFL 346
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
74-343 |
1.54e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 43.75 E-value: 1.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 74 GAVADRVNRKWLVIGTDLLSSLTMLIMFILAtifgPSLLFIYVSAALLSICASFYsVALTSSIPSLVDEGRIQKASALNQ 153
Cdd:cd17490 52 GILSDRIGKRKLFIIIGLLFTVLASLIMILF----PSPWGLLIARFLSGIAAATW-VSFTVLYASYFPPDEAAKAMGLIN 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 154 TAASLSNILGPIIGGVVFGFFSIKSFFLLNSITFFLAVILQLFIvfdlykKEVAESKERFLTSIKEGFSYVKRQhEIYGL 233
Cdd:cd17490 127 LVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFI------KEERREKKPVLTELKELLSVLKDK-KLLFF 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 234 MKIALWVNFFACGLTVALPYIIVHTLHLSSKQLGTVEGM-LAVGMLMGAIALSVRKEVKNPFRSIYTGLFLFAGLSLCTV 312
Cdd:cd17490 200 SLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIyLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIP 279
|
250 260 270
....*....|....*....|....*....|....*
gi 1005591338 313 F----PLLVTIPKVASFIYYIAFMMLTGISIMIVN 343
Cdd:cd17490 280 FapnlTLLYLLQALNGFGTGILFPLLMSLSIEGVP 314
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
21-129 |
1.94e-04 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 43.44 E-value: 1.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 21 ILMMIGkMTSLLGAGIYTFAMGLYVLKTTGSGM----GFAITLVCGSLpRMICGPIAGAVADRVNRKWLVIGTDLLSSLT 96
Cdd:cd17367 225 LLLVVG-LTAGGTLAFYTWTTYLQKFLVNTAGFskgdATWITTAALLV-FMLLQPLGGRLSDRIGRRPLLLFFGIGGTLA 302
|
90 100 110
....*....|....*....|....*....|....
gi 1005591338 97 M-LIMFILATIFGPSLLFIYVSAALLSIcaSFYS 129
Cdd:cd17367 303 TvPLLSALDHTDSPYTAFALVLVGLVFL--SGYT 334
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
60-386 |
2.93e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.57 E-value: 2.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 60 VCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMFilatiFGPSLLFIYVSAALLSICASFYSVAlTSSIPSL 139
Cdd:cd17330 41 SSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLG-----LSRNLWLLFLARFLDGLTGGNVSVA-QAYIADI 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 140 VDEGRIQKASALNQTAASLSNILGPIIGGVVFGFFSIKSFFLLNSITFFLAVILQLFIVFDLYkkevaeskerfltsike 219
Cdd:cd17330 115 TDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPLR----------------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 220 gfsyvkrqheiyGLMKIALWVNFFACGLTVALPYIIVHTLHLSSKQLGTVEGMLAVGMLMGAIALSVRKEVKNPFRSIYT 299
Cdd:cd17330 178 ------------RLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLR 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 300 GLFLFAglslctvFPLLVTIPKVASFIYYIAFMMLTGISIMIVNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAPLGMI 379
Cdd:cd17330 246 LGLLLA-------IIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPL 318
|
....*..
gi 1005591338 380 VYGLLLD 386
Cdd:cd17330 319 LAGPLYS 325
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
17-197 |
5.64e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 41.79 E-value: 5.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 17 TRNIILMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFAITLV-CGSLPRMICGPIAGAVADRVNRKWLVigtdLLSSL 95
Cdd:COG2223 204 DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAaLFALLGALGRPLGGWLSDRIGGRRVL----LIVFA 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 96 TMLIMFILATIFGPSLLFIYVSAALLSICASFYSVALTSSIPSLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFF- 174
Cdd:COG2223 280 LMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATg 359
|
170 180
....*....|....*....|...
gi 1005591338 175 SIKSFFLLNSITFFLAVILQLFI 197
Cdd:COG2223 360 SYTAAFLVFAVLALVALVLTLLL 382
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
18-174 |
2.12e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 40.27 E-value: 2.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 18 RNIILMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMG-FAITLVCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLT 96
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAAlVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 97 MLIMFILATifgPSLLFIYVSAALLSICASFYSVALTSSIPSLVDEGRIQ-------KASALNQTAASLSNILGPIIGGV 169
Cdd:COG2211 308 LLLLFFLGP---GNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKtgrrregLYFGIFTFAIKLGQALAGALAGL 384
|
....*
gi 1005591338 170 VFGFF 174
Cdd:COG2211 385 LLALF 389
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
59-212 |
3.18e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.45 E-value: 3.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 59 LVCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMfilatIFGPSLLFIYVSAALLSICASFYSVALTSSIPS 138
Cdd:COG0738 49 LFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLF-----ALAPSYPLLLLALFLLGLGLGLLDVAANPYVAA 123
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1005591338 139 LVDEGRIQKASALnQTAASLSNILGPIIGGVVFGF---FSIKSFFLLNSITFFLAVILQLFIVFDLYKKEVAESKER 212
Cdd:COG0738 124 LGPETAASRLNLL-HAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGS 199
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
28-193 |
4.32e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.06 E-value: 4.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 28 MTSLLGAGIYTFAMGLYVLKTTGSGMGFAITL-VCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMfilatI 106
Cdd:cd17370 208 AVALFALGNFSFAFLILRAQELGLSAALIPLLyALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGF-----A 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 107 FGPSLLFIYVSAALLSICASFYSVALTSSIPSLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFFSIKSFFLLNSIT 186
Cdd:cd17370 283 LGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVL 362
|
....*..
gi 1005591338 187 FFLAVIL 193
Cdd:cd17370 363 ALIALLL 369
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
51-211 |
4.79e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 39.13 E-value: 4.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 51 SGMGFAITLVCGSlprmICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMFILATIFGPSLLfiyvsAALLSICASFYSV 130
Cdd:PRK09874 56 SGLVFSITFLFSA----IASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLIL-----RALLGLLGGFVPN 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 131 AlTSSIPSLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFFSIKSFFLLNSITFFLAVILQLFIVFDLY----KKEV 206
Cdd:PRK09874 127 A-NALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIRENFqpvsKKEM 205
|
....*
gi 1005591338 207 AESKE 211
Cdd:PRK09874 206 LHMRE 210
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
17-196 |
6.03e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 38.74 E-value: 6.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 17 TRNIILMMIGKMTSLLGAGIYTFAMGLYVLKTTG----------SGMGFAITLVCGSLprmicgpiAGAVADRVNRKWLV 86
Cdd:cd17331 206 LPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGltpeengylmSYAGVLGMVVQGLL--------VGPLTKRFGERSLL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 87 IGTDLLSSLTMLIMFILATIFgpsllFIYVSAALLSICASFYSVALTSSIPSLVDEGRIQKASALNQTAASLSNILGPII 166
Cdd:cd17331 278 KLSVALLAIGYLLLAFVTTVW-----QLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTI 352
|
170 180 190
....*....|....*....|....*....|
gi 1005591338 167 GGVVFGFFSIKSFFLLNSITFFLAVILQLF 196
Cdd:cd17331 353 GGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
68-284 |
8.57e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 38.06 E-value: 8.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 68 ICGPIAGAVADRVN------RKWLVIGTDLLSSLTMLIMFILATIFGPSLLFIYVSAALLSICASFYSVALTSSIPSL-V 140
Cdd:pfam13347 48 FTDPIVGHIIDRTRtrwgrrRPWLLLSAIILAVSFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELtR 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1005591338 141 DEGRIQKASALNQTAASLSNILGPIIGGVVFGFFSI-----KSFFLLNSITFFLAVILQLFIVFDLYKKEVAESKERFLt 215
Cdd:pfam13347 128 DYDERTSLTSYRSFFSVGGGLLAAALAFPLVLILGGtglerKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTG- 206
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1005591338 216 sikegfsyVKRQHEIYGLMKIAL----WVNFFACGLTVALPYIIVHTL--HLSSKQLGT---VEGMLAVGMLMGAIAL 284
Cdd:pfam13347 207 --------QKEAGSLLDMLKEVFrnraFLILLASFLLAALAMGVLNGLllYYFRYVLGNgfaASAFPLVFTIGALLGI 276
|
|
| |
