|
Name |
Accession |
Description |
Interval |
E-value |
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
23-400 |
1.72e-51 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 176.21 E-value: 1.72e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 23 SFVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYG 102
Cdd:COG2271 22 NYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 103 LVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLa 182
Cdd:COG2271 102 LLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 183 lftvkevqafrknhtvevqgteprcmslaqslrfvgtnrNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAI 262
Cdd:COG2271 181 ---------------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 263 MSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAP 342
Cdd:COG2271 222 LSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFP 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1011507046 343 PELRGTTAGFVNLFNQIGALTAPIILSTVLTATGnYQTALMALSISPIIGAILLSLIR 400
Cdd:COG2271 302 KKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLL 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
23-402 |
1.16e-44 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 158.89 E-value: 1.16e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 23 SFVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYG 102
Cdd:COG2223 17 AFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 103 LVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLA 182
Cdd:COG2223 97 LLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 183 LFTVKEVQAFRKnhtvevQGTEPRCMSLAQSLRfvgtNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAI 262
Cdd:COG2223 177 WLFLRDPPAGAA------AAAKASLRDQLEALR----DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 263 MSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFAnTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAP 342
Cdd:COG2223 247 AALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALA-LGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFP 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 343 PELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILLSLIRLK 402
Cdd:COG2223 326 TKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRR 385
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
23-396 |
1.71e-41 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 149.64 E-value: 1.71e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 23 SFVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYG 102
Cdd:cd17319 15 NYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 103 LVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLA 182
Cdd:cd17319 95 YVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLW 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 183 LFTVkevqafrknhtvevqgteprcmslaqslrfvgtnRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAI 262
Cdd:cd17319 175 WFYL----------------------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 263 MSIYGIAAVIAKPTIGFISDRIS-LPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAA 341
Cdd:cd17319 221 AAIPFLAGAIGMILGGRLSDRLLrGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLL 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1011507046 342 PPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILL 396
Cdd:cd17319 301 PGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLV 355
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
30-400 |
4.48e-39 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 143.49 E-value: 4.48e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 30 WSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLL 109
Cdd:cd17325 15 IIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 110 GIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEv 189
Cdd:cd17325 95 GLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPE- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 190 qafrknHTVEVQGTEPRCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIA 269
Cdd:cd17325 174 ------PRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 270 AVIAKPTIGFISDRIslPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTT 349
Cdd:cd17325 248 SALSQPPAGKLSDRI--GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTA 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 350 AGFVNLFNQIGALTAPiILSTVLTATGNYQTALMALSISPIIGAILLSLIR 400
Cdd:cd17325 326 MGLFNTAFSLGMVLGP-LLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
33-361 |
2.40e-37 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 138.57 E-value: 2.40e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 33 LMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIV 112
Cdd:COG2814 32 ALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 113 SGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVQAF 192
Cdd:COG2814 112 AGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 193 RKNHtvevqgteprcmsLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVI 272
Cdd:COG2814 192 ARAR-------------LRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 273 AKPTIGFISDRISLPRnyLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGF 352
Cdd:COG2814 259 GALLAGRLADRFGRRR--LLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGL 336
|
....*....
gi 1011507046 353 VNLFNQIGA 361
Cdd:COG2814 337 YNSAFFLGG 345
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
33-397 |
2.51e-34 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 130.82 E-value: 2.51e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 33 LMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIV 112
Cdd:cd17475 18 LAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 113 SGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVQAF 192
Cdd:cd17475 98 YGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 193 RknhtvevqGTEPRCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVI 272
Cdd:cd17475 178 S--------AATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 273 AKPTIGFISDRIsLPRNYLAAIVMFLFSPALLIFANTTNPD-----MLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRG 347
Cdd:cd17475 250 GRIGLGRVSDRV-FGGRRRPVLVITAAIAAAALLVLSLLSPgtplwLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAG 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1011507046 348 TTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILLS 397
Cdd:cd17475 329 TALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
23-365 |
5.02e-30 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 118.29 E-value: 5.02e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 23 SFVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYG 102
Cdd:pfam07690 9 ALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 103 LVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLA 182
Cdd:pfam07690 89 LVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 183 LFTVKEVQAFRKNhtvevqGTEPRCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWAnlYLVKQLHVTPIFAGAI 262
Cdd:pfam07690 169 LLPRPPPESKRPK------PAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLP--LYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 263 MSIYGIAAVIAKPTIGFISDRIS-LPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAA 341
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGrRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....
gi 1011507046 342 PPELRGTTAGFVNLFNQIGALTAP 365
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
27-396 |
9.72e-30 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 118.30 E-value: 9.72e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 27 RLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLR 106
Cdd:cd06174 12 RGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 107 FLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVH--YGWQMAFLITALLPLLVFFLALF 184
Cdd:cd06174 92 FLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 185 TVKEVQafrknHTVEVQGTEPRCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMS 264
Cdd:cd06174 172 VVPDPP-----ESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLS 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 265 IYGIAAVIAKPTIGFISDRIsLPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPE 344
Cdd:cd06174 247 LFGLAGALGSLLLGLLSDRL-IGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPE 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1011507046 345 LRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILL 396
Cdd:cd06174 326 IRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
60-400 |
2.10e-25 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 106.12 E-value: 2.10e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 60 ALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGI 139
Cdd:cd17473 49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 140 FMSCTSFGITVVNGYAPFVAVhYGWQMAFLITaLLPLLVFFLALFTVKEVQAFRKNHTVEVQGTEPRCmslaqslrfvgT 219
Cdd:cd17473 129 QSAAMSLGGVVFLLLGGALAE-IGWRAPFLVY-LLALPVLILVLLFLPEPARKSKSAASPGAATAAAL-----------P 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 220 NRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISlpRNYLAAIVMFLF 299
Cdd:cd17473 196 WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLG--KRRLLAIGFALM 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 300 SPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQ 379
Cdd:cd17473 274 ALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLS 353
|
330 340
....*....|....*....|.
gi 1011507046 380 TALMALSISPIIGAILLSLIR 400
Cdd:cd17473 354 GAFLILGVLALVLAIVLLLLR 374
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
24-376 |
4.02e-25 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 105.54 E-value: 4.02e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 24 FVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGL 103
Cdd:TIGR00881 8 YLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 104 VLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPF-VAVHYGWQMAFLITALLPLLVFFLA 182
Cdd:TIGR00881 88 ALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVFIVPGIIAIIVSLIC 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 183 LFTVKE---------VQAFRKNHTVEVQGTEPRCMSLAQS-LRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQL 252
Cdd:TIGR00881 168 FLLLRDspqscglppAEEMPNEEPDGDAEKKEEELTKKQIfLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEK 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 253 HVTPIFAGAIMSIYGIAAVIAKPTIGFISDRI-SLPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSP 331
Cdd:TIGR00881 248 GFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGP 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1011507046 332 --LTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATG 376
Cdd:TIGR00881 328 qmLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
30-398 |
6.13e-25 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 104.55 E-value: 6.13e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 30 WSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLL 109
Cdd:cd17324 18 IQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 110 GIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEV 189
Cdd:cd17324 98 GLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 190 QAFRKNHTvevqgteprcmSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIA 269
Cdd:cd17324 178 PPKKPGSL-----------GLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 270 AVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFANttNPDMLYITAPLLGMGAFMYSPLTNAIIIQAApPELRGTT 349
Cdd:cd17324 247 GVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGP--SPLLLLVGLVLWGLGFFAAHSALQTRVLRLA-PEARGLA 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1011507046 350 AGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSIspIIGAILLSL 398
Cdd:cd17324 324 SSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAAL--LLLALLLAL 370
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
23-395 |
1.13e-24 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 104.57 E-value: 1.13e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 23 SFVMRLSWSSLMPIVNE---ALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSY 99
Cdd:COG2807 27 ALNLRPAITSVGPLLPEiraDLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 100 EYGLVLRFLLGIVSGPVQSACLKAIGEHFsAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVF 179
Cdd:COG2807 107 ALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLAL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 180 FLALFTVKEVQAFRKnhtvevqgteprcmSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANL--YLVkQLHVTPI 257
Cdd:COG2807 186 LLWLPLLRRRPAAAA--------------AAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLppILR-DAGLSAA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 258 FAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAI-VMFLFSPALLIFANTTnpdMLYITAPLLGMGAFMYSPLTNAI 336
Cdd:COG2807 251 TAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLgLLGLAGLLGLLLAPGS---LPWLWAVLLGLGQGGLFPLALTL 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 337 IIQAAP-PELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAIL 395
Cdd:COG2807 328 IGLRARtPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVA 387
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
29-395 |
9.85e-23 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 98.77 E-value: 9.85e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 29 SWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFL 108
Cdd:COG0738 26 LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 109 LGIVSGPVQSACLkAIGEHFSAEQRGTAVGIFMSCTSFGITVVN---GYAPFVAVHYGWQMAFLITALLPLLVFFLALFT 185
Cdd:COG0738 106 LGLGLGLLDVAAN-PYVAALGPETAASRLNLLHAFFSLGALLGPllgGLLILLGLSLSWHLPYLILAVLLLLLALLFLRS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 186 vkevqafrknHTVEVQGTEPRCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSI 265
Cdd:COG0738 185 ----------KLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 266 YGIAAVIAKPTIGFISDRISlpRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQaAPPEL 345
Cdd:COG0738 255 FWGGMTIGRFLGGFLLKRFG--PVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALD-GLGKR 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1011507046 346 RGTTAGFVNLFNQIGALTAPIILSTVLTATGnYQTALMALSISPIIGAIL 395
Cdd:COG0738 332 TAAAVSAVLIMGIVGGAIGPPLIGFLADAFG-LRAAFLVPLVCYLLILLL 380
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
24-400 |
1.13e-21 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 95.42 E-value: 1.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 24 FVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGL 103
Cdd:cd17312 16 YVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 104 VLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLAL 183
Cdd:cd17312 96 VLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILF 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 184 FTVKEvqafrknhtvevqgteprcmslaqslrfvgTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIM 263
Cdd:cd17312 176 FFLRD------------------------------SPPYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 264 SIYGIAAVIAKPTIGFISDRISL-PRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLgMGAFMYSP---LTNAIIIQ 339
Cdd:cd17312 226 SLYEVGGIAGTILAGLLSDKLFGgRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFL-IGFFVGGPinlIGGAAAQD 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 340 AAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGnYQTALMALSISPIIGAILLSLIR 400
Cdd:cd17312 305 IGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYG-WSTVFYFLISAALLSVLLLLSLW 364
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
27-400 |
2.58e-20 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 91.92 E-value: 2.58e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 27 RLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLR 106
Cdd:cd17345 19 RNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSATSSVGLM 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 107 FLLGIVSGPVQS----ACLKAIGEHFSAEQRGTAVGIFMSCTSFG---ITVVNGYAPFVAVHYGWQMAFLITALLPLLVF 179
Cdd:cd17345 99 FILLFLNGWFQGmgwpPSGRTMVHWFSKKERGTWTSIWNISHNVGgglVGPLAGLGLAIFGDGWWRGAFIFPAIIAIIVA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 180 FLALFTVKE---------VQAFRKNHTVEVQG-TEPRCMSLAQSL-RFVGTNRNILLLAVMGFFATGTTWGVTTWANLYL 248
Cdd:cd17345 179 VIVLFLGKDtpeseglppIEEYKGDYPEEADGeEEEQELSAWEIFvKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 249 VKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVmFLFSPALLIFANTTNPDMLYITAPLLGMGAFM 328
Cdd:cd17345 259 SEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPTGII-FMILVIVALIVYWLAPNVLVDLIALIALGFLI 337
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1011507046 329 YSP--LTNAIIIQAAPPELRGTTAGFVNLFNQI-GALTAPIILSTVLTATGnYQTALMALSISPIIGAILLSLIR 400
Cdd:cd17345 338 YGPvmLIGLQALELVPKKAAGTAAGLTGLFGYLgGSVLATALIGIIVDHFG-WNGGFIVLLASCILAIIFLALVA 411
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
23-396 |
3.00e-20 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 91.52 E-value: 3.00e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 23 SFVMRLSWSSLMPIVneALHFTAQQGTSYLTAfyfGYALTVLP---------GGLLADRFGYRKSILGSLVAMAIVTGLM 93
Cdd:cd17329 8 SFLNRLGFFMVWPFM--AIYLHQQLGLSASIV---GLVLALSAvagivasliGGRLADRFGRKPVMLAGLLLRALGFALL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 94 STVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVhYGWQMAFLITAL 173
Cdd:cd17329 83 GFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 174 LPLLVFFLALFTVKEVQAFRKNHTVevqgteprcMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLH 253
Cdd:cd17329 162 LFLLAALVLLFLLPETRPKRRAAEK---------TEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 254 VTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVmfLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLT 333
Cdd:cd17329 233 LGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGIL--LFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAV 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1011507046 334 NAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIIlSTVLTATGNYQTALMALSISPIIGAILL 396
Cdd:cd17329 311 QTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLV-GGLLLDLLGPGLPWLILAALGLIAAALL 372
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
34-374 |
9.37e-20 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 89.92 E-value: 9.37e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 34 MPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVS 113
Cdd:cd17321 19 LPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 114 GPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLAlftvkevqafr 193
Cdd:cd17321 99 AAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA----------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 194 knhtvevqgteprcmslaqslrfvgtnRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIA 273
Cdd:cd17321 168 ---------------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVA 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 274 KPTIGFISDRISlPRnYLAAIVMFLFSPALLIFANTTNPDMLYITAP---LLGMGAFMYSPLTNAIIIQAAPPELRGTTA 350
Cdd:cd17321 221 APLAGRLADRFG-PR-LVLVAGLLLTAVGLLLLALLGADSSVWLLLPglvLLGLGLGLFATPLTNAALSSVPKEKAGAAS 298
|
330 340
....*....|....*....|....
gi 1011507046 351 GFVNLFNQIGALTAPIILSTVLTA 374
Cdd:cd17321 299 GILNTARQLGGALGVALLGALLTA 322
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
53-395 |
3.52e-19 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 88.03 E-value: 3.52e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 53 TAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQ 132
Cdd:cd17489 38 GLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSR 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 133 RGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFtvkevqafRKNHTVEVQGTEPRCMSLAQ 212
Cdd:cd17489 118 RGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFL--------VKDPPPVAAEEAEAGTRAFR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 213 SLRfvgtNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTpifAGAIMSIYGIAAVIAKPTIGFISDRisLPRNYLA 292
Cdd:cd17489 190 RLV----EKKVLPPALILFLASIAYGAISTFLPLYAAERGISN---AGLFFTVYAIALLLSRPFSGKLSDR--KGPKTVI 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 293 AIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVL 372
Cdd:cd17489 261 IPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVA 340
|
330 340
....*....|....*....|...
gi 1011507046 373 TATGnYQTALMALSISPIIGAIL 395
Cdd:cd17489 341 ELFG-YRAMFLLAAVVVLLALVL 362
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
41-396 |
5.64e-19 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 87.27 E-value: 5.64e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 41 LHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSAC 120
Cdd:cd17316 31 LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 121 LKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVH----YGWQMAFLITALLPLLVFFLAlftvkevqafrknh 196
Cdd:cd17316 111 STYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLlsgdWGWRILFLIGALPALLALLLR-------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 197 tvevqgteprcmslaqslrfvgtnRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPT 276
Cdd:cd17316 177 ------------------------RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALI 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 277 IGFISDRISLPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLF 356
Cdd:cd17316 233 AGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNL 312
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1011507046 357 NQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILL 396
Cdd:cd17316 313 GRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVA 352
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
44-400 |
6.17e-19 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 87.74 E-value: 6.17e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 44 TAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKA 123
Cdd:cd17371 32 DEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAAL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 124 IGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVA----VHYGWQMAFLITALLPLLVFFLALFtVKEVQAFRKnHTVE 199
Cdd:cd17371 112 MAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFpllpPEIAWRVLFLLGALPALLVLFIRRF-VKEPPQWQA-ARAA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 200 VQGTEPRcmsLAQSLRFVGTNRNILLLA-VMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIG 278
Cdd:cd17371 190 RRHFADR---PSLRELFSPPLLRTTLLAsLLATGALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGG 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 279 FISDRISLPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPlLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQ 358
Cdd:cd17371 267 FLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILILGFP-LGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGR 345
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1011507046 359 IGALTAPiILSTVLTATGNYQTALMALSISPIIGAILLSLIR 400
Cdd:cd17371 346 IIGALFP-FLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLL 386
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
31-398 |
3.56e-18 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 85.31 E-value: 3.56e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 31 SSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLG 110
Cdd:cd17474 19 DPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 111 IVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVvngyAPFVA---VHYGWQMAFLITALLPLLVFFLALFTVK 187
Cdd:cd17474 99 IGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAV----GPLLGgllAAISWRYPFFLLAALIPVAFLAILFLLP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 188 EvqafRKNHTVEVQGTEPRCMSLAQslrfvgTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYG 267
Cdd:cd17474 175 E----PKEKAKSSSATKLRDLKKAL------RGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWS 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 268 IAAVIAKPTIGFISDRISLPRnYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRG 347
Cdd:cd17474 245 VLLALGSLFVGRLLKKRFGAR-RILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERG 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 348 TTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILLSL 398
Cdd:cd17474 324 TASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
60-399 |
8.45e-18 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 84.57 E-value: 8.45e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 60 ALTVLPGGLLAD----RFGYRKS-ILGSLVAMAIVTGLM------STVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHF 128
Cdd:COG2211 60 AITDPLIGALSDrtrtRWGRRRPwILIGAIPLALSFVLLftapdlSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELT 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 129 -SAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHY------GWQMAFLITALLPLLVFFLALFTVKEVQAFRKNHTvevq 201
Cdd:COG2211 140 pDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKV---- 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 202 gteprcmSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFIS 281
Cdd:COG2211 216 -------SLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLA 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 282 DRISLPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPEL-------RGTTAGFVN 354
Cdd:COG2211 289 KRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFT 368
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 355 LFNQIGALTAPIILSTVLTATG------NYQTALMALSISPIIGAILLSLI 399
Cdd:COG2211 369 FAIKLGQALAGALAGLLLALFGyvagaaQSPSALTGIRLLFFLLPAVLLLL 419
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
23-396 |
1.10e-17 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 83.86 E-value: 1.10e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 23 SFVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYeYG 102
Cdd:cd17355 15 SWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSL-WQ 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 103 LVLRFLLGIVSGPVQSA--CLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFF 180
Cdd:cd17355 94 LYLLWGLLGGGGAGTLAavAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 181 LALftvkevqAFRKNHTVEVQG---TEPRCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVkQLHVTPI 257
Cdd:cd17355 174 PVL-------LLLRRRPADLALrayDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLA-DRGISPA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 258 FAGAIMSIYGIAAVIAKPTIGFISDRISLPRnyLAAIVMFLFSPALLIFANTTNPD-MLYITAPLLGMGAFMYSPLTNAI 336
Cdd:cd17355 246 AAAVALALIGLFNIVGRLLSGWLGDRYSPRR--LLAASYALRALGLALLLLLPFPPlALLLFAALFGLGWGATVPLTAAL 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 337 IIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILL 396
Cdd:cd17355 324 AARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLV 383
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
67-371 |
1.64e-17 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 83.47 E-value: 1.64e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 67 GLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVqSACLKAIGEHFSAEQRGTAVGIF----MS 142
Cdd:cd17391 57 GRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYV-PNATALIASQTPKEKSGWALGTLstgvVA 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 143 CTSFGITVvngyAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEvqafrkNHTVEVQGTEPRCMSLAQSLRFVGTnrn 222
Cdd:cd17391 136 GTLIGPLL----GGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKE------DFKPVEKKKMVSTKEVWNSVPNPSL--- 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 223 ILLLAVMGFFATGTTWGVTTWANLYlVKQLH----VTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIvmfL 298
Cdd:cd17391 203 LISLFVTTFIIQLANQSIEPILTLY-IRQLMgdasNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGAL---L 278
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1011507046 299 FSPALLIF-ANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTV 371
Cdd:cd17391 279 ASALLYIPqAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAI 352
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
27-400 |
5.89e-17 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 82.00 E-value: 5.89e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 27 RLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLR 106
Cdd:cd17343 19 RKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSVWVFSILW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 107 FLLGIVSGPVQSACLKAIGEHFSAEQRGTavgiFMSCTSFGITVVNGYAPFVAV----HYGWQMAFLITALLPLLVFFLA 182
Cdd:cd17343 99 FLNGLAQGLGWPPCAKILRKWFSPSQFGT----WWSVLSTSMNLAGSLGPILATllalSYGWRSTLSISGTVAVVMSVVC 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 183 LFTVKEVQAFRknhTVEVQGTEPRCMSLAQSLRFVGTNRNILL--------LAVMGFFATGTTWGVTtwANLYLVKQLHV 254
Cdd:cd17343 175 LLFIKNEPSDV---GLNNIEEEESKGKKKKSPRGESTLKELLLspflwllsLGYLVVFGVKTAVTDW--GQLFLIQDKGQ 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 255 TPIFAGAIMSIYGIAAVIAKPTIGFISDRISL---------PRNYLAAIVMFLFSPALLIFANTTNPD--MLYITAPLLG 323
Cdd:cd17343 250 SALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAkhgsssrgnPRMPLALVFMAGLTVSLHLFRVHITSDssELFILLLGFL 329
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1011507046 324 MGAFMYSPLT--NAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATgNYQTALMALSISPIIGAILLSLIR 400
Cdd:cd17343 330 IGFSLYGPIAifGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHY-DWRTAFLLLEILCAITVVILFLLR 407
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
23-383 |
8.46e-17 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 81.14 E-value: 8.46e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 23 SFVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRK-SILGSLVAMAIVTGLMSTVQSYEY 101
Cdd:cd17341 11 GFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRvFIASLLLLLIPLLALALAVSSYWG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 102 GLVLRFLLGIvSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAP-------FVAVHYGWQMAFLITALL 174
Cdd:cd17341 91 LLVLGFLLGF-AGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPliagaivFDGGFVGWRNAFFVPGIL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 175 PLLVFFLALFtvkevqaFRKNHTvevQGTEPRCMSLAQsLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHV 254
Cdd:cd17341 170 LAIAAVLVLL-------FGDDLP---TGKASALEFLKV-QLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 255 TPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFANTTNPDMLYITApLLGMGAFMYSPLTN 334
Cdd:cd17341 239 PLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFL-ALFVALGLGAGAGN 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1011507046 335 AIIIQAAPPELR---GTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALM 383
Cdd:cd17341 318 GSVFRMVPFIFRrelGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFS 369
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
53-396 |
9.87e-17 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 81.13 E-value: 9.87e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 53 TAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQ 132
Cdd:cd17328 41 TVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 133 RGTAVGIFmsctSFGITV-------VNGYapFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVqafRKNHTVEVQGTEP 205
Cdd:cd17328 121 RTRALGVF----YFAIPLgsglgyvVGGL--VAQATGGWRWAFRVTGVLGVLLAILLLLFVREP---PRGAAEGGVMAKS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 206 RCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAK----PTIGFIS 281
Cdd:cd17328 192 TATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGvlgvLLGGILA 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 282 DRISLPRN----YLAAIVMFLFSP--ALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNL 355
Cdd:cd17328 272 DRLRRKTPradpLVCAVGLLAAAPflFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQIL 351
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1011507046 356 FNQIGALTAPIILSTVLTATGNY------------QTALMALSISPIIGAILL 396
Cdd:cd17328 352 LSHLLGDAGSPYLIGLISDLLRQnkdsplaeaaslQYALLLCSFVLVLGGFFF 404
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
51-399 |
3.76e-16 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 79.20 E-value: 3.76e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 51 YLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLM-----STVQSYEYGLVLRFLLGIVSGPVQSACLKAIG 125
Cdd:cd06173 39 VLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLallalLGSLSLWLLLVLAFLLGIASAFFGPARQALLP 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 126 EHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVkevqafRKNHTVEVQGTEP 205
Cdd:cd06173 119 ELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIR------RPPPAAPGESSSL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 206 RCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRis 285
Cdd:cd06173 193 LLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKR-- 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 286 LPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQiGALTAP 365
Cdd:cd06173 271 RRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNS-GAMPLG 349
|
330 340 350
....*....|....*....|....*....|....
gi 1011507046 366 IILSTVLTATGNYQTALMALSISPIIGAILLSLI 399
Cdd:cd06173 350 ALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
44-401 |
1.09e-15 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 77.63 E-value: 1.09e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 44 TAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKA 123
Cdd:cd17365 32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 124 IGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTvkevqafrknhtvevqgt 203
Cdd:cd17365 112 VSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGT------------------ 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 204 eprcmslaqslrfvgtnrniLLLAVMgFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDR 283
Cdd:cd17365 174 --------------------LLLWVT-FFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADR 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 284 ISlPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALT 363
Cdd:cd17365 233 FG-PKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAIL 311
|
330 340 350
....*....|....*....|....*....|....*...
gi 1011507046 364 APIILSTVLTATGNYQTALMALSISPIIGAILLSLIRL 401
Cdd:cd17365 312 GPLLGGLLLAAGLGPESVFLALAIPAALGALAVLLLRL 349
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
24-401 |
1.97e-15 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 76.98 E-value: 1.97e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 24 FVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGL 103
Cdd:cd17333 9 GLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 104 VLRFLLGIVSGPVQSACLKAIGEHFSaEQRGTAVGIFMSCTSFGITVVNGYA-PFVAVHYGWQMAFLITALLPLLVFFLA 182
Cdd:cd17333 89 VLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIAtSLLTSELSWSWAYLIIGLIYLLLAILI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 183 LFTVKEVQAFRKNHTVEVQGTEPrcmSLAQSLRfvgtNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAI 262
Cdd:cd17333 168 LLTLFPELPSARNPQQSVGAFSA---SASRLLR----NPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 263 MSIYGIAAVIAKPTIGFISDRIsLPRNYLAAIVmFLFSPALLIFANTTNPDMLYITAPLLGMGAfmySPLTNAIIIQAAP 342
Cdd:cd17333 241 LSGFWVGITIGRLLGGPISRRI-KPHTLLVLSG-SGALLGLLILLLAPTLVVGLVATALLGLFM---AALFPTILSLGIS 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 343 --PELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMAlsisPIIGAILLSLIRL 401
Cdd:cd17333 316 nlPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLI----TILYAIIFVLALL 372
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
54-400 |
3.99e-15 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 76.05 E-value: 3.99e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 54 AFYFGYALTVLPGGLLADRFGYRK-SILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAeQ 132
Cdd:cd17352 46 LLLGVSLFSGPLSSALVNRFGCRPvAIAGGLLAALGLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEK-K 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 133 RGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFlalftvkevqafrknhtvevqgteprCMSLAQ 212
Cdd:cd17352 125 RGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCV--------------------------CGLLLR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 213 SLRfvgtNRNILLLAVMGFFATGTTWGVTTWANLYLvKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLA 292
Cdd:cd17352 179 LLK----DPTFVLLALGVSFAMLGFFVPFVYLPSYA-KSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLY 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 293 AIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVL 372
Cdd:cd17352 254 IFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLR 333
|
330 340
....*....|....*....|....*...
gi 1011507046 373 TATGNYQTALMALSISPIIGAILLSLIR 400
Cdd:cd17352 334 DYTGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
27-395 |
6.52e-14 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 72.34 E-value: 6.52e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 27 RLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLR 106
Cdd:cd06180 15 RFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 107 FLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPF-VAVHYGWQMAFLITALLPLLVFFLALFT 185
Cdd:cd06180 95 FLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAgLGGGLSWRAGWLALALLSAVLLLLSFLL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 186 VKEVqafrknhtvevqgtEPRCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYlVKQLHVTPIFAGAIMSI 265
Cdd:cd06180 175 LRRG--------------PSAPTEASAAESAPGLNRPLWRLALAYGLFGFGYIITATFLPLI-ARETGAGSLLAGLLWSL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 266 YGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFANTtnPDMLYITAPLLGmGAFMYSPLTNAIIIQAAPPEL 345
Cdd:cd06180 240 FGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPG--PAGLVLSAVLFG-GTFMAITALVMALARELAPPA 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1011507046 346 RGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAIL 395
Cdd:cd06180 317 APRALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAALL 366
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
34-184 |
7.83e-14 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 71.38 E-value: 7.83e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 34 MPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVS 113
Cdd:COG0477 37 LPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGA 116
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 114 GPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALF 184
Cdd:COG0477 117 GGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLR 187
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
53-378 |
9.54e-14 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 71.82 E-value: 9.54e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 53 TAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQ 132
Cdd:cd17477 38 SAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNEN 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 133 RGTAVGIFMSCTSFGITVvnGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVQAFRKNHtvevqgteprcmslaq 212
Cdd:cd17477 118 RGRVLGLYSTVLGLGFAL--GPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEEAE---------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 213 SLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVkQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLA 292
Cdd:cd17477 180 SISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGL-RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 293 AIVMFLFSPALLIFANTTNPdMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVL 372
Cdd:cd17477 259 CALLGALAALLLPLVPGLPL-ALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALM 337
|
....*.
gi 1011507046 373 TATGNY 378
Cdd:cd17477 338 DAFGPH 343
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
39-391 |
2.12e-13 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 71.07 E-value: 2.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 39 EALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQS 118
Cdd:cd17503 24 GDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 119 ACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLItaLLPLLVFFLALFTVKEVQAFRknhtv 198
Cdd:cd17503 104 LAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYI--NLPIGILALLLAPLLDLRLFK----- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 199 evqgteprcmslaqslrfvgtNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIG 278
Cdd:cd17503 177 ---------------------DRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 279 FISDRISLPRNYLAAIVMFLFSPALLIFAN-TTNPDMLYITAPLLGMG-AFMYSPLtNAIIIQAAPPELRGTTAGFVNLF 356
Cdd:cd17503 236 RLLDKFGPRLLLLAGLLLLALGTLLLAFLTpDTSLWLIILPLFIRGLGmGLVFMPL-NTLALNSLPPEQIGDATALFNTI 314
|
330 340 350
....*....|....*....|....*....|....*
gi 1011507046 357 NQIGALTAPIILSTVLTATGNYQTALMALSISPII 391
Cdd:cd17503 315 RQLGGSIGTALLATLLTNRTQFHHSRLSELLAQQV 349
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
33-396 |
2.67e-13 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 70.66 E-value: 2.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 33 LMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIV 112
Cdd:cd17478 18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 113 SGPVQSACLKAIGeHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGwQMAFLITALLPLLVFFLALFTVKEVQAF 192
Cdd:cd17478 98 SAAFHPEGARLAS-QAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFG-GLGLLILLIIPGLAVALLLLRLRPLKKP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 193 RKNHTVEVQgteprcmslAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVkQLHVTPIFAGAIMSIYGIAAVI 272
Cdd:cd17478 176 EAKKAAAKS---------SARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLV-QRGYSLVFAGLLLSLFLFAGAI 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 273 AKPTIGFISDRISlpRNYLAAIVMFLFSPALLIFANTTNPdMLYITAPLLGMGAFMYSPLTnAIIIQAAPPELRGTTAGF 352
Cdd:cd17478 246 GTLIGGPLSDRFG--RRRVIIASLLLAAPFLLLFLLTPGI-WSYILLVLAGFLLFASFPVT-VVLAQELLPGNVGLASGL 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1011507046 353 VNLFNQ-IGALTAPIIlsTVLTATGNYQTALMALSISPIIGAILL 396
Cdd:cd17478 322 MMGLSFgLGGIGAPVL--GALADAFGLESVLLILALLPLLGALLA 364
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
47-372 |
3.60e-13 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 70.46 E-value: 3.60e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 47 QGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGE 126
Cdd:TIGR00895 53 QLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSE 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 127 HFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKE----------VQAFRKNH 196
Cdd:TIGR00895 133 YAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPEsidflvskrpETVRRIVN 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 197 TVEVQGTEPRCMSLAQSLRFVGTNRNIL------------LLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMS 264
Cdd:TIGR00895 213 AIAPQMQAEAQSALPEQKSTQGTKRSVFkalfqgktaritVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGA 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 265 IYGIAAVIAKPTIGFISDRISlpRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPE 344
Cdd:TIGR00895 293 LFNFGGVIGSIIFGWLADRLG--PRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTA 370
|
330 340
....*....|....*....|....*...
gi 1011507046 345 LRGTTAGFVNLFNQIGALTAPIILSTVL 372
Cdd:TIGR00895 371 IRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
24-398 |
1.54e-12 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 67.99 E-value: 1.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 24 FVMRLSWSSLMPIVNealHFTAQQGTSYLTAFYFG-----YALTVLPG----GLLADRFGYRKSILGSLVAMAIVTGLMS 94
Cdd:cd17330 6 FLDALGFGIVFPVLP---FYVREFNKLGASGYYVGllqssYSLGQFLAsplwGRLSDRYGRKPVLLLSLAGSAVSYVLLG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 95 TVQSYEYGLVLRFLLGIVSGPVqSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALL 174
Cdd:cd17330 83 LSRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 175 PLLVFFLALFTVkevqafrknhtvevqgteprcmslaqslrfvgtnRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHV 254
Cdd:cd17330 162 ALLNLVLVLFFL----------------------------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGF 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 255 TPIFAGAIMSIYGIAAVIAK-PTIGFISDRISLPRNYLAAIVMFLFSPALLIFAntTNPDMLYITAPLLGMGAFMYSPLT 333
Cdd:cd17330 208 SPSQIGLLLALVGIAGILAQlLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFA--SSVPLLVLAAAILAFGTGIVFPAL 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1011507046 334 NAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMAlSISPIIGAILLSL 398
Cdd:cd17330 286 SALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLA-AGLLLIALFLLSL 349
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
64-395 |
1.63e-12 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 68.40 E-value: 1.63e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 64 LPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVL-RFLLGIVSGPVQSACLKAIGeHFSAEQRGTAVGIFMS 142
Cdd:cd17490 49 IPLGILSDRIGKRKLFIIIGLLFTVLASLIMILFPSPWGLLIaRFLSGIAAATWVSFTVLYAS-YFPPDEAAKAMGLINL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 143 CTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFtVKEVQAFRKNHTVEVQgteprcmslaqSLRFVGTNRN 222
Cdd:cd17490 128 VNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLF-IKEERREKKPVLTELK-----------ELLSVLKDKK 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 223 ILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRiSLPRNYLAAIVMFLFSPA 302
Cdd:cd17490 196 LLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYK-KLGERNTIIIGFLLLGAY 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 303 LLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGnYQTAL 382
Cdd:cd17490 275 CFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFG-LQTGF 353
|
330
....*....|...
gi 1011507046 383 MALSISPIIGAIL 395
Cdd:cd17490 354 FVIGVIALLAAIL 366
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
52-191 |
1.89e-12 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 67.96 E-value: 1.89e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 52 LTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVL--RFLLGIVSGPVQSACLKAIGEHFS 129
Cdd:cd17380 40 LSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLIlsRILLGLGEGVHFPSMTSLFSRWVP 119
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1011507046 130 AEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVQA 191
Cdd:cd17380 120 VSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLPPVWA 181
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
52-191 |
4.43e-12 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 66.87 E-value: 4.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 52 LTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGL--VLRFLLGIVSGPVQSACLKAIGEHFS 129
Cdd:cd17318 62 LSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGAliVLRILQGLAQGVTFPAMHALWAKWAP 141
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1011507046 130 AEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVQA 191
Cdd:cd17318 142 PLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLVLPVWA 203
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
67-376 |
1.37e-11 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 65.71 E-value: 1.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 67 GLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSAClKAIGEHFSAEQRGTAVGIFMSCTSF 146
Cdd:PRK09874 75 GGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNAN-ALIATQVPRNKSGWALGTLSTGGVS 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 147 GITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKE-VQAFRKNHTVEVQgteprcmSLAQSLRfvgTNRNILL 225
Cdd:PRK09874 154 GALLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIREnFQPVSKKEMLHMR-------EVVTSLK---NPKLVLS 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 226 LAVMGFFATGTTWGVTTWANLY---LVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISlPRNYLaaIVMFLFSPA 302
Cdd:PRK09874 224 LFVTTLIIQVATGSIAPILTLYvreLAGNVSNIAFISGMIASVPGVAALLSAPRLGKLGDRIG-PEKIL--ITALIFSVL 300
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1011507046 303 LLI-FANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATG 376
Cdd:PRK09874 301 LLIpMSFVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYG 375
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
31-373 |
1.57e-11 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 65.86 E-value: 1.57e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 31 SSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLG 110
Cdd:TIGR00711 22 NVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 111 IVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVQ 190
Cdd:TIGR00711 102 FGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILPRDK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 191 A---------------------------------FRKNHTV--EVQGTEPRCMSLAQSLRF--------VGTNRNILLLA 227
Cdd:TIGR00711 182 PaasenfdflgllllsvglgsllyglsegpergwFDSNEILilSITGLVAIIAFVVWELTDdnplvdlrLFKYRNFTIGC 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 228 VMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFspALLIFA 307
Cdd:TIGR00711 262 VYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIGLILYAV--GFYWRA 339
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 308 NTTNPDMLY--ITAPLLGMG---AFMYSPLTNaIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLT 373
Cdd:TIGR00711 340 FTFTPDTPFlaIALPQFIRGfgmGCFFMPLTT-IALSGLPPHKIARGSSLSNFTRQLGGSIGTALITTILT 409
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
34-396 |
2.24e-11 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 64.90 E-value: 2.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 34 MPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVS 113
Cdd:cd17320 22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 114 GPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEvqafr 193
Cdd:cd17320 102 AAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPE----- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 194 knhTVEVQGTEPRCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIA 273
Cdd:cd17320 177 ---TLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 274 KPTIGFISDRISLPRN-YLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMG---AFMYSPLTNAIIiqAAPPELRGTT 349
Cdd:cd17320 254 SLLNGRLVRRFGPRRLlRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFfgfGLIFPNATSLAL--EPFPHVAGTA 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1011507046 350 AGFVNLFNQ-IGALTAPIILSTVLTATGNYQTALMALSISPIIGAILL 396
Cdd:cd17320 332 SALLGFLQFlIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
51-188 |
3.43e-11 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 60.74 E-value: 3.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 51 YLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSA 130
Cdd:TIGR00880 3 LLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPP 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1011507046 131 EQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKE 188
Cdd:TIGR00880 83 EERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
223-395 |
7.09e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 62.97 E-value: 7.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 223 ILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISlpRNYLAAIVMFLFSPA 302
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFG--RRRVLAIGLLLWGLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 303 LLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGnYQTAL 382
Cdd:COG2271 89 TLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-WRAAF 167
|
170
....*....|...
gi 1011507046 383 MALSISPIIGAIL 395
Cdd:COG2271 168 LILGLPGLLLALL 180
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
33-189 |
1.08e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 62.58 E-value: 1.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 33 LMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFG--YRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLG 110
Cdd:COG2271 203 LPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAG 282
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1011507046 111 IVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEV 189
Cdd:COG2271 283 FGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRET 361
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
39-396 |
1.43e-10 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 62.27 E-value: 1.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 39 EALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQS 118
Cdd:cd17327 34 EDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFP 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 119 ACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVH------YGWQMAFLITALLPL---LVFFLAL------ 183
Cdd:cd17327 114 GFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKIlgvgglAGWRWLFIIEGLITIiigLVIFFWLpdnpsk 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 184 ---FTVKE----VQAFRKNHTvevqGTEPRCMSLAQSLRFVGTNRNILLlaVMGFFATGTTWGVTTWANLYLVKQLHVTP 256
Cdd:cd17327 194 awfLTEEEkelaVERLRANQT----GKGDQKFKWKQIKEAFKDPRTWLL--FLFFFCSQITNNGISNFLPLILKSLGFYS 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 257 IFAGAIMSIYGIAAVIAKPTIGFISDRIslPRNYLAAIVMFLFS-PALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNA 335
Cdd:cd17327 268 LQTNLLSVPIGALGAVSLLIAALLSDRF--KKRGLFAIFACVLAlVGSIILLAAPNPPGAYFAAYILGGGSYAGFPILLS 345
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1011507046 336 -IIIQAAPPELRGTTAGFVNLFNQIGALTAPIILstVLTATGNYQTALMALSISPIIGAILL 396
Cdd:cd17327 346 wISSNCAGYTKRATVLAIMLIFYNVGNIVAPQIF--RAGDAPRYIPGNIALLVCACVSIVLS 405
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
24-396 |
2.05e-10 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 61.65 E-value: 2.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 24 FVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGL 103
Cdd:cd17488 16 YLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSSSLWAFA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 104 VLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLAL 183
Cdd:cd17488 96 VLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYVPGIIAILMGIVLC 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 184 FTVKEvqafrknhtvevqgteprcmslaqslrfvgTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIM 263
Cdd:cd17488 176 WRLRD------------------------------RPPYIWLLAFCYVLVYVVRTAINDWGNLYLSETHGYSLVKANSAV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 264 SIYGIAAVIAKPTIGFISDRIS----LPRNYLAAIVMfLFSPALLIFANTTNPDMLYITapLLGMGAFMYSP--LTNAII 337
Cdd:cd17488 226 SLFEVGGLIGALVAGWGSDKLFkgnrGPMNLIFALGL-LVSVGALWLVPVHSYWLLATC--FFTIGFFVFGPqmLIGMAA 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1011507046 338 IQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGnYQTALMALSISPIIGAILL 396
Cdd:cd17488 303 AECSHKDAAGSATGFVGLFAYLGAALAGYPLAKVIESWG-WSGFFIVISIAAAISGLLL 360
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
30-367 |
2.19e-10 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 61.82 E-value: 2.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 30 WSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLL 109
Cdd:cd17323 18 YSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 110 GIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEV 189
Cdd:cd17323 98 GFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLPIV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 190 QafrknhtvevqgteprCMSLAQSLRFVgtnrnILLLAVMGFfatgttwgvttwaNLYLVKQLHVTPIFAGAIMSIYGIA 269
Cdd:cd17323 178 L----------------LLGLYVGLVYA-----ILYLFLTAF-------------PYVFGEVYGFSPGEVGLMYLPIGIG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 270 AVIAKPTIGFISDRISLPRN-------------YLAAIVMFLFSPALLIFANTTNPD----MLYITAPLLGMGAFMYSPL 332
Cdd:cd17323 224 ALIGSIIGGRLSDYYYRRLKkknggkpepearlPPAFIGAFLFPIGLFIFGWTIYPHihwiVPIIGSAFFGFGLMLIFQS 303
|
330 340 350
....*....|....*....|....*....|....*
gi 1011507046 333 TNAIIIQAAPPELRGTTAGFvNLFNQIGALTAPII 367
Cdd:cd17323 304 SLTYLVDSYPKYAASALAAN-TLVRSIFAAIFPLF 337
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
221-398 |
2.54e-10 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 61.53 E-value: 2.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 221 RNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFS 300
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 301 PALLIFAntTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPiILSTVLTATGNYQT 380
Cdd:COG2814 89 SLLCALA--PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGP-LLGGLLADLFGWRW 165
|
170
....*....|....*...
gi 1011507046 381 ALMALSISPIIGAILLSL 398
Cdd:COG2814 166 VFLVNAVLALLALLLLLR 183
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
23-361 |
2.95e-10 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 61.16 E-value: 2.95e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 23 SFVMRLSWSSLMP-IVNEALHFTAQQ-GTSYLTAFYFGyALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTV-QSY 99
Cdd:TIGR00886 13 SFLVWFAFSPLAVfLIKDDLGLSTAQlGNLVAVPVLAG-AVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSY 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 100 EYGLVLRFLLGIVSGPVQSaCLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVA----------VHYGWQMAFL 169
Cdd:TIGR00886 92 SVLLLIRLFIGIAGGSFAS-CMPWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIgslifgggqpAHLAWGWAFV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 170 I-TALLPLLVFFLALFTVKEvqafrknhTVEVQGTEPRCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWanLYL 248
Cdd:TIGR00886 171 IvPAGILLLPALLIFFVGAD--------TPPGKPATGKLSFKEALKVFGNRHTWILALLYSVTFGSFLGVSSIFA--MLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 249 VKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFANTTNPDMLyiTAPLLGMGAFM 328
Cdd:TIGR00886 241 KDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFLVVLGLVSDGSLA--AFIVLFVALFF 318
|
330 340 350
....*....|....*....|....*....|....*.
gi 1011507046 329 YSPLTNAIIIQAAP---PELRGTTAGFVNLFNQIGA 361
Cdd:TIGR00886 319 FAGAGNGSTFALVPhifRRATGAVSGLIGAIGNLGG 354
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
226-400 |
7.08e-10 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 60.12 E-value: 7.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 226 LAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLI 305
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 306 FANTTNpdMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPiILSTVLTATGNYQTALMAL 385
Cdd:pfam07690 81 FASSLW--LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGP-LLGGLLASLFGWRAAFLIL 157
|
170
....*....|....*
gi 1011507046 386 SISPIIGAILLSLIR 400
Cdd:pfam07690 158 AILSLLAAVLLLLPR 172
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
53-372 |
7.18e-10 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 60.49 E-value: 7.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 53 TAFYFGYALTVLPGGLLADRFGYRKSILGSLVAmaivTGLMSTVQSYEYGLVLRFLLGIVSGPVQS----ACLKAIGEHF 128
Cdd:PRK11663 65 TLFYITYGVSKFVSGIVSDRSNARYFMGIGLIA----TGIINILFGFSSSLWAFALLWVLNAFFQGwgwpVCAKLLTAWY 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 129 SAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKE---------VQAFRKNHTVE 199
Cdd:PRK11663 141 SRTERGGWWAIWNTAHNVGGALIPLVVGAIALHYGWRYGMMIAGIIAIVVGLFLCWRLRDkpqamglpsVGEWRHDALEL 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 200 VQGTEPRCMSLAQSL-RFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIG 278
Cdd:PRK11663 221 AQQQEGAGLSRKEILtKYVLLNPYIWLLSFSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAG 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 279 FISDRI----SLPRNYLAAIVMFLFSPALLIFANTTnpdMLYITAPLLGMGAFMYSP--LTNAIIIQAAPPELRGTTAGF 352
Cdd:PRK11663 301 WGSDKLfngnRGPMNLIFAAGILLSVGSLWLMPFAS---YVMQAACFFTIGFFVFGPqmLIGMAAAECSHKEAAGAATGF 377
|
330 340
....*....|....*....|
gi 1011507046 353 VNLFNQIGALTAPIILSTVL 372
Cdd:PRK11663 378 VGLFAYLGAALSGYPLAKVL 397
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
29-184 |
7.19e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 59.88 E-value: 7.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 29 SWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGL-VLRF 107
Cdd:cd17477 206 AFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALlVLLF 285
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1011507046 108 LLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVvngyAPFVAvhyGWQMAFLITALLPLLVFFLALF 184
Cdd:cd17477 286 LWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVI----GPLLA---GALMDAFGPHGLFLFLAAVALL 355
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
52-402 |
9.46e-10 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 59.92 E-value: 9.46e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 52 LTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYeYGLVL-RFLLGivSGPVQSACLKAIGEHFSA 130
Cdd:cd17472 38 LGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSI-YGLILgRALQG--SGAISSVVMALLADLTRE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 131 EQRGTA---VGIFMScTSFGITVVNGyaPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVqafrKNHTVEvqgtepRC 207
Cdd:cd17472 115 ENRTKAmalIGASIG-IAFAISMVLG--PLLAAHLGVSGLFLITAILSLVSLLILLFFVPDP----PKIVQI------SE 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 208 MSLAQSLRFVgTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLP 287
Cdd:cd17472 182 KEKKKLKKLL-KNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMK 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 288 RNYLAAIVMFLFSPALLIFANtTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPiI 367
Cdd:cd17472 261 QVFVSSILLIAVGFLLLLFAA-TSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGG-A 338
|
330 340 350
....*....|....*....|....*....|....*
gi 1011507046 368 LSTVLTATGNYQTALMALSIspIIGAILLSLIRLK 402
Cdd:cd17472 339 LGGLLWGLLGYSSVFLTILI--LALLWLLVSFLLP 371
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
52-400 |
1.51e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 59.13 E-value: 1.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 52 LTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIvSGPVQSACLKAIGEHFSAE 131
Cdd:cd17504 37 LTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGI-GGAVFPLAFALVREEFPPE 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 132 QRGTAVGIFMSctSFGITVVNGY--APFVAVHYGWQMAFLITAllPLLVFFLALFTVKEVQAFRknhtvevqgteprcms 209
Cdd:cd17504 116 RVPVAQGILSA--TFGIGAGIGLplGGWIVQHLGWRWIFWTAA--PVAVLLAALVPLIDLRLLR---------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 210 laqslrfvgtNRNILLLAVMGFFATGTTWGVTtwanlYLVKQLHVTP---------IFAGAIMSIYGIAAVIAKPTIGFI 280
Cdd:cd17504 176 ----------RRNVLLANITALLAGFGMFMVF-----QLLPQLLQLPtptgfglgiTEAGLLLLPGALVMLIAGPLAGRL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 281 SDRISLPRNYLAAIVMFLFSpALLIFANTTNPDMLYITAPLLGMG-AFMYSPLTNaIIIQAAPPELRGTTAGFVNLFNQI 359
Cdd:cd17504 241 IARVGPRRVLLIGLVISAVG-LLLLALLHSSLWALVVALLLIGIGlGLAFASLPN-IVVESVPPDRTGIATGMNTVLRTI 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1011507046 360 GALTAPIILSTVLTA------------TGNYQTALMALSISPIIGAILLSLIR 400
Cdd:cd17504 319 GSAIGPAIAGAILTTytvsitsggvptEGAYVLAFLIGAALALAALLLSLLIP 371
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
36-184 |
2.11e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 58.38 E-value: 2.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 36 IVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYE--YGLVLRFLLGIVS 113
Cdd:cd17316 203 YLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSptLLLLLLFILSFFV 282
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 114 GPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALF 184
Cdd:cd17316 283 GGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
67-394 |
3.84e-09 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 57.92 E-value: 3.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 67 GLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYE-YGL-------VLRFLLGIVSGPVQSACLKAIGEHFSAEQR----- 133
Cdd:cd17369 65 GHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYAqIGIlapillvLLRLLQGLALGGEWGGAVLMAVEHAPPKRRgfygs 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 134 ----GTAVGIFMSCTSF-GITVVNGYAPFVAvhYGWQMAFLITALLpLLVFFLALFTVKEVQAFRKnhtVEVQGTEPRcM 208
Cdd:cd17369 145 fpqlGAPVGLLLATGVFlLLSALLSDEAFLS--WGWRIPFLLSAVL-VAVGLYIRLRLEETPVFRR---AKEAGQVVR-A 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 209 SLAQSLRfvgTNRNILLLAVMGFFATGTTWGVTTWANL-YLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLP 287
Cdd:cd17369 218 PLVEVLR---RHWRALLLAIGLRLAENVLFYLFTTFALsYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRR 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 288 RNYLA-AIVMFLFSPALLIFANTTNPdMLYITAPLLGMGAF---MYSPLtNAIIIQAAPPELRGTTAGFV-NLFNQIGAL 362
Cdd:cd17369 295 PVYLAgALLAALFAFPFFWLLDTGST-WLIVLAAVVVLGVLhgmMYGPQ-AAFLAELFPTRVRYTGASLGyQLGAILGGG 372
|
330 340 350
....*....|....*....|....*....|..
gi 1011507046 363 TAPIILSTVLTATGNYQTALMALSISPIIGAI 394
Cdd:cd17369 373 FAPLIATALVAATGSWWPVALYLAALAVISLV 404
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
66-394 |
9.65e-09 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 56.89 E-value: 9.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 66 GGLLADRFGyRKSILGSLVA----MAIVTGLmstVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFM 141
Cdd:PRK11551 70 GGRLADRIG-RKRILIVSVAlfglFSLATAQ---AWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMY 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 142 SCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVQAFRKNHTVEVQGTeprcmSLAQSLRFVGTNR 221
Cdd:PRK11551 146 CGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAFAQAAGAGKQRA-----PVLRALFGEGRAT 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 222 NILLLAVMGFFATGTTWGVTTWANLYLVKQlHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSP 301
Cdd:PRK11551 221 ATLLLWISYFFTLIVLYFLLNWLPSLLVGQ-GLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVLLIYAGILASL 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 302 ALLIFANTTNPdmLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTA 381
Cdd:PRK11551 300 AALAAAPSFAG--MLLAGFAAGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLLALGRSTVGV 377
|
330
....*....|...
gi 1011507046 382 LMALSISPIIGAI 394
Cdd:PRK11551 378 IGASIPVILVAAL 390
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-150 |
2.65e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 54.98 E-value: 2.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 7 LTQTGILLTLWLTFLLSFVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAM 86
Cdd:COG2814 204 LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL 283
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1011507046 87 AIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITV 150
Cdd:COG2814 284 ALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
29-399 |
3.14e-08 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 54.92 E-value: 3.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 29 SWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSIL--GSLVAMAIVTGLMSTVQSYEYgLVLR 106
Cdd:cd17353 21 AWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILigGILFGLGFILSAFAISLPLLF-LGYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 107 FLLGIVSGPVQSACLKAIGEHFSaEQRGTAVGIfmscTSFGItvvnGYAPFVAV--------HYGWQMAFLITALLPLLV 178
Cdd:cd17353 100 VLGGIGAGIGYITPVSTAVKWFP-DKRGLATGI----VIAGF----GLGSLIFSpliaylinTVGVPTTFLILGIIFLII 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 179 FFLALFTVKE----VQAFRKNHTVEVQGTEPRCMSLAQSLRfvgtNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHV 254
Cdd:cd17353 171 IVIGAFLIRDppkgWVPPGVDPLANNAENSPRDYTPREMLR----TPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 255 TPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFANTTNP-DMLYITAPLLGMGAFMysPLT 333
Cdd:cd17353 247 DAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVlFVLGVALIGFCYGGGF--ALF 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1011507046 334 NAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIIlSTVLTATGNYQTALMALSISPIIGAILLSLI 399
Cdd:cd17353 325 PALTADFFGTKNAGTNYGLLYTAKGVGGLIGPII-AAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
39-183 |
3.90e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 54.86 E-value: 3.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 39 EALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQS 118
Cdd:cd17370 227 QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQES 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1011507046 119 ACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLAL 183
Cdd:cd17370 307 IERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
129-337 |
4.97e-08 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 54.53 E-value: 4.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 129 SAEQRGTAVGIFMSCTSFGITVVNGYAPFV-------AVHYGWQMAFLITALLPLLVFFLALFTVKEVQAFRKNHTVEVq 201
Cdd:cd17332 130 DPEERTSLTSWRMFFATIGGLLVTVLPPPLvayfgggNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKL- 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 202 gteprcmSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAgAIMSIYGIAAVIAKPTIGFIS 281
Cdd:cd17332 209 -------PLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELV-LLLLLILSGALLALLPWPPLK 280
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1011507046 282 DRISLPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAII 337
Cdd:cd17332 281 KRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAML 336
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
29-191 |
9.26e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 53.70 E-value: 9.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 29 SWSSLmpIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFL 108
Cdd:COG0738 231 DWLPL--YLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLAL 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 109 LGIVSGPVQSACLKAIGEHFSaEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKE 188
Cdd:COG0738 309 VGLGLSLMFPTIFSLALDGLG-KRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRK 387
|
...
gi 1011507046 189 VQA 191
Cdd:COG0738 388 RRK 390
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
57-396 |
9.52e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 53.70 E-value: 9.52e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 57 FGYALTVLpGGLLADRFGYRKS--ILGSLVAMAIVtGLMSTVQSYEYGLVLRFLLGIVSGpVQSACLKAIGEHFSAEQ-R 133
Cdd:cd17370 46 LGSLLRLF-SGYLSDRTGKRKPlvILGYGLSALAK-PLLALAGSWQLVLLLRILERLGKG-IRTPPRDALLADATPPSgR 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 134 GTAVGIFMSCTSFGITVvngyAPFVAV------HYGWQMAFLItALLPLLVFFLALFTVKEvqAFRKNHTVEVQGTEPRC 207
Cdd:cd17370 123 GKAFGLHRALDTLGAVL----GPLLAAlllyllGGNYRTIFLL-AAIPALLALLILLFVVK--EYPRPPKLRKKSKKTSL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 208 MSLAQSLRFVGTnrnILLLAVMGFFATGTTwgvttwanLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLP 287
Cdd:cd17370 196 KKLPKAFWLYLL---AVALFALGNFSFAFL--------ILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRK 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 288 RNYLAAIVMFLFSPalLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPII 367
Cdd:cd17370 265 KLLILGYLSLALAY--LGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLI 342
|
330 340
....*....|....*....|....*....
gi 1011507046 368 LStVLTATGNYQTALMALSISPIIGAILL 396
Cdd:cd17370 343 AG-YLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
221-376 |
1.31e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 52.89 E-value: 1.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 221 RNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFS 300
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1011507046 301 PALLIFAntTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATG 376
Cdd:COG0477 93 SLLCGLA--PSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG 166
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
54-185 |
2.72e-07 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 52.19 E-value: 2.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 54 AFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQR 133
Cdd:cd17315 42 SLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIR 121
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1011507046 134 GTAVGIFMSCTSFGITVVN--GYAPFVAVHYGWQMAFLITALLPLLVFFLALFT 185
Cdd:cd17315 122 GALGTLNQLMITFGILLAYllGLALSLSPPGWWRLMFALAAVPALLQLLLMFFL 175
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
67-310 |
3.91e-07 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 51.78 E-value: 3.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 67 GLLADRFGYRKS-ILGSLVAMAIVTGLMSTVQSYeyglVLRFLLGIVSGPVQSAC---LKAIGEHFSAEQRGTAVGIFMS 142
Cdd:cd17471 53 GRLSDRGGDRKPlILLALLAGALGYLLFAFLRNY----WVLLLVGVVLLSLGAAAfpqLFALAREYADRSSGRDATLFNS 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 143 ----CTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVQAFRKNHTVevqgteprcmslAQSLRFVG 218
Cdd:cd17471 129 vlraAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATP------------ASSLVKAP 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 219 TNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMsiyGIAAVIAKPTI---GFISDRISLPRNYLAAIV 295
Cdd:cd17471 197 VNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLF---GLAAALEIPIMllaGLLAKRFGKRRLLLAGFL 273
|
250
....*....|....*
gi 1011507046 296 MFLFSPALLIFANTT 310
Cdd:cd17471 274 AGVLFYLGLALATSL 288
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
45-184 |
4.14e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 51.45 E-value: 4.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 45 AQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAI 124
Cdd:cd17490 230 FQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLS 309
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 125 GEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALF 184
Cdd:cd17490 310 IEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLA 369
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
23-285 |
4.44e-07 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 51.85 E-value: 4.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 23 SFVMRLSWSSLMPIVNEALHFTAQQ-GTSYLTAFYfGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEY 101
Cdd:PLN00028 48 CFVSTFAAAPLLPIIRDNLNLTKSDiGNAGIASVS-GSIFSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 102 GLVLRFLLGIvSGPVQSACLKAIGEHFSAEQRGTAVGI-------------FMSCTSFGITVVNGYAPFVAvhygWQMAF 168
Cdd:PLN00028 127 FIAVRFFIGF-SLATFVSCQYWMSTMFNGKIVGTANGIaagwgnlgggvtqLLMPLVFPLIKDAGAPSFTA----WRIAF 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 169 LITALLPLLVFFLALFTVKEVQ--AFRknhTVEVQGTEPRcMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANL 246
Cdd:PLN00028 202 FVPGLLHIIMGILVLTLGQDLPdgNYR---ELKKSGTMPK-DSFSKVLRYGVTNYRTWILALTYGYSFGVELTMDNIIAE 277
|
250 260 270
....*....|....*....|....*....|....*....
gi 1011507046 247 YLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRIS 285
Cdd:PLN00028 278 YFYDRFGLSLETAGAIAASFGLMNLFARPAGGYLSDVAA 316
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
53-187 |
5.16e-07 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 51.04 E-value: 5.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 53 TAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQ 132
Cdd:cd17317 32 TIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKY 111
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1011507046 133 RGTAVGIFMSCTSFGITVVNGYAPFVAvhyGWQMAFLITALLPLLVFFLALFTVK 187
Cdd:cd17317 112 RSFVGILFGLFWALGYMLLALLAYLIR---DWRWLQLAISLPGLLFLLLLWWLPR 163
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
67-203 |
6.52e-07 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 50.77 E-value: 6.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 67 GLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAE-QRGTAVGIFMSCTS 145
Cdd:cd17383 51 GTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFFARSLQGVGSAFADTAGLAMIADRFTEEaERSKALGIALAFIS 130
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 146 FGITVVngyAPFVAVHY---GWQMAFLITALLPLLVFFLALFTVKEVQAFRKNHTVEVQGT 203
Cdd:cd17383 131 FGCLVA---PPFGGILYefaGKEVPFLILAFVCLLDGLLLLLVMKPVRRETRANMPEPVGT 188
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
27-398 |
6.64e-07 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 50.87 E-value: 6.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 27 RLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRK-SILGSLVAMAIVTGLMSTVQSYEYGLVL 105
Cdd:cd17314 19 ILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPlMALAGIMVLAGYTYLSYVFNSFPLSYAC 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 106 RFLLGIVSGPVQSACLKAIGEHFSaEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALlpllvffLALFT 185
Cdd:cd17314 99 FVFIGAGTGILYGSAVLVTTQYFP-DTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGI-------LAAIV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 186 VKEVQAFRKNHTVEVQGTEPRCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSI 265
Cdd:cd17314 171 LSVVSLLGFKEPPDNQARLHVQKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLDAPSFVTKLMSI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 266 YGIAAVIAKPTIGFISDRIsLPRNYLAAIVMFLFSPAL--LIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPP 343
Cdd:cd17314 251 YGLFNAFGRLLWGIVADFF-GGRLSTLSILLTILGLGLcaFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGT 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1011507046 344 ELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILLSL 398
Cdd:cd17314 330 ESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILLA 384
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
53-188 |
1.06e-06 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 50.40 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 53 TAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQ 132
Cdd:TIGR00898 134 SCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQ 213
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1011507046 133 RGTAVGIFMSCTSFGITVVNGYAPFVAvhyGWQMAFLITAlLPLLVFFLALFTVKE 188
Cdd:TIGR00898 214 RAIVGTLIQVFFSLGLVLLPLVAYFIP---DWRWLQLAVS-LPTFLFFLLSWFVPE 265
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
27-396 |
1.51e-06 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 49.68 E-value: 1.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 27 RLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVL--PGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLV 104
Cdd:pfam06779 9 RFSYTPILPVMIAEGQFSLSQAGLLAAANYAGYLAGALlaSFAWRHGASRLRPALLAGLLATVLLLLAMAATSSFWAVLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 105 LRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALF 184
Cdd:pfam06779 89 IRFLAGVASAAVMIFGSSLILGHATAARRAFVGALLFAGVGIGIALSGLLVPLGLQLGLGGSSLWYGAGVLSAVLTLAVF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 185 TVKEVQAFRK-NHTVEVQGTEPRCMSLAQslrfvgtnrnilLLAVMGFFATGTTWGVTTWANlyLVKQLHVTPIFAGAIM 263
Cdd:pfam06779 169 PLLPRRAPRHaSAPAPAAKPLQRSLPLWI------------LTLAYGLAGFGYIITATFLPA--MARDGFGGPAAAALFW 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 264 SIYGIAAVIAKptigFISDRISLPRNYLAAIVMFLFSPALLIFANT--TNPDMLYITAPLLGMGAFMYSPLTNAIIIQAA 341
Cdd:pfam06779 235 SLFGLAAALGV----LVWLRAAKRWGTRPALTAALLIQALGVLLSLlsPSPAGLAVSSLLFGGTFMAITSLVMQLARELA 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1011507046 342 PPELRgTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILL 396
Cdd:pfam06779 311 PPAPR-RLLGLMTASFGIGQILGPLLASLLTAATGGLTPALLLAAAALVLAALIV 364
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
48-361 |
4.51e-06 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 48.33 E-value: 4.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 48 GTSYLTAFyfgyALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEH 127
Cdd:cd17502 36 GTAYLLTS----TAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 128 FSAEQRGTAVGIFMSctSFGITVVNGyaPFV----AVHYGWQMAFLITalLPLLVFFLALFtvkevqafrknhtvevqgt 203
Cdd:cd17502 112 VPPRERGKYQGYIGA--VFGIASVAG--PLIggafTDHLSWRWCFYIN--LPIGGLALALL------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 204 eprcmslaqslrfvgtnRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDR 283
Cdd:cd17502 167 -----------------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISK 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 284 ISLPRN-YLAAIVMFLFSPALLIFANTTNPDMLYITAP-LLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGA 361
Cdd:cd17502 230 TGRYKPlIVIGTILMSVGAGLLTTLTLDTSKWLLIGYLiLLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGG 309
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
48-402 |
7.29e-06 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 47.84 E-value: 7.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 48 GTSYLTAFYFGYALTVlpGGLL-----------ADRFGYRKSILGSLVAMAIV-TGLMSTVQ--SYEYGLVLrFLLGIV- 112
Cdd:COG2270 45 GDPAAATALWGYALAI--AGLLvallapvlgaiADRSGRKKPFLAFFTLLGVLaTAALFFVApgGLWLGLLL-FVLANIg 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 113 ---SGPVQSACLKAIGEH-----FSAeqRGTAVGIFMSCTSFGITVV----NGYAPFVAVHYGWQMAFLITALLPLLVFF 180
Cdd:COG2270 122 fegSLVFYNAFLPDIATPeeigrVSG--LGWALGYLGGVLLLLINLAlflkPEAFGLPDAGEAVRISFLLTALWWLLFAL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 181 LALFTVKEVQAFRKNHTVEVQGTEPRcmSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTP---I 257
Cdd:COG2270 200 PLFLFLPERPRPGPAPPRGAVRAGFR--ELRRTLRELRRYRDLLRFLLAYFFYRDGVQTVIAFAGIYAAGVLGFSTtelI 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 258 FAGAIMSIYGIAAVIAkptIGFISDRISLPRNYLAAIVMFLFSPALLIFANTTNpdMLYITAPLLG--MGAfMYSpLTNA 335
Cdd:COG2270 278 VFGLLVQIVAALGALL---FGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTAL--AFWILGLLIGlvMGG-IQA-LSRS 350
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1011507046 336 IIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILLSLIRLK 402
Cdd:COG2270 351 LLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGSQRLGILSLIVFFVIGLVLLLRVKVP 417
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
67-369 |
8.71e-06 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 47.63 E-value: 8.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 67 GLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIV--SGPVQSACLKAIGehfSAEQRGTAVGIFMSCt 144
Cdd:cd17388 59 GALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITgaTGAVAAAYIADVT---PPEQRARNFGLLGAA- 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 145 sFGITVVNGYA-PFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVQAFRKNhtvevQGTEPRCMSLAQSLRFVGTNRNI 223
Cdd:cd17388 135 -FGLGFIAGPAlGGLLGEISPRAPFLVAAGLNGLNFLLGLFVLPESLPPERR-----RAFRWRRANPFGSLRWLTGFPGL 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 224 LLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKP-TIGFISDRISLPRNYLAAivMFLFSPA 302
Cdd:cd17388 209 LGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAfVTGPIAKRLGEKRAILLG--LAADALG 286
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 303 LLIFANTTNPDMLYITAPLLGMGAfMYSPLTNAIIIQAAPP----ELRGTTAGFVNLFNQIGALTAPIILS 369
Cdd:cd17388 287 FLLLAFATQGWMVFPILILLALGG-IAGPALQGLLSRQVPEneqgELQGVLTSLTSLTSIIGPLLFTGIFA 356
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
33-367 |
1.17e-05 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 47.23 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 33 LMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGI- 111
Cdd:PRK12307 40 IMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMg 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 112 VSGPVQSACLKAIgEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLItALLPLLVFFLALFTVKEVQA 191
Cdd:PRK12307 120 MAGEYACASTYAV-ESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFV-GLLPVLLVIYIRARAPESKE 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 192 FRKNhTVEVQGTEPRCMSLAQSLRFVGT-NRNILLLAVMGFFATGTTWGVTTWANLYLVKQLH---VTPIFAGAIMSIYG 267
Cdd:PRK12307 198 WEEA-KLSGKGKHSQSAWSVFSLSMKGLfNRAQFPLTLCVFIVLFSIFGANWPIFGLLPTYLAgegFDTGVVSNLMTAAA 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 268 IAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFANTTNpdMLYITAPLLGMGA--FMYSPLTNAIIIQAAPPEL 345
Cdd:PRK12307 277 FGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFPLFRIPQDN--YLLLGACLFGLMAtnVGVGGLVPKFLYDYFPLEV 354
|
330 340
....*....|....*....|..
gi 1011507046 346 RGTTAGFVNLFNQIGALTAPII 367
Cdd:PRK12307 355 RGLGTGLIYNLAATSGTFNSMA 376
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
247-402 |
1.29e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 46.78 E-value: 1.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 247 YLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRIslPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGA 326
Cdd:cd17478 21 LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRK--PRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGS 98
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1011507046 327 FMYSPLTNAIIIQAAPPElRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILLSLIRLK 402
Cdd:cd17478 99 AAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
227-399 |
1.54e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 46.65 E-value: 1.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 227 AVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIF 306
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 307 AntTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILS-TVLTATGNYQTALMAL 385
Cdd:cd06174 81 A--PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGiLASSLGFGWRAVFLIA 158
|
170
....*....|....
gi 1011507046 386 SISPIIGAILLSLI 399
Cdd:cd06174 159 AALALLAAILLLLV 172
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
57-177 |
2.12e-05 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 46.19 E-value: 2.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 57 FGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTa 136
Cdd:cd17379 44 LGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRT- 122
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1011507046 137 VGIFMSCT-SFGITVVNGYAPFVAVHYGWQMAFLITALLPLL 177
Cdd:cd17379 123 VGIVYQMFfTLGLLILPGIAYFIPHWRWLQLAVTLPNFLFLL 164
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
260-402 |
2.15e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 46.50 E-value: 2.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 260 GAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFAN-TTNPDMLYITAPLLGMGAFMYSPLTNAIII 338
Cdd:pfam00083 49 GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgKWSVYQLIVGRVLVGIGVGGASVLAPMYIS 128
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1011507046 339 QAAPPELRGTTAGFVNLFNQIGALTAPIIlsTVLTATGNYQTALMALSISPIIGAILLSLIRLK 402
Cdd:pfam00083 129 EIAPKKLRGALGSLYQLAITFGILLAYIF--GLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLF 190
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
43-186 |
3.25e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 45.66 E-value: 3.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 43 FTAQQGTSYLTAFYFGYALTVLP----GGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQS 118
Cdd:cd17489 220 YAAERGISNAGLFFTVYAIALLLsrpfSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFP 299
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1011507046 119 ACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTV 186
Cdd:cd17489 300 ALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
1-147 |
3.44e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 45.81 E-value: 3.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 1 MKKGFTLTQTGILLTLWLTFLLSFVMRLSWsslMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSIL 80
Cdd:TIGR00895 243 LFQGKTARITVLLWLLYFMLLVGVYFLTNW---LPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTAL 319
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1011507046 81 GSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFG 147
Cdd:TIGR00895 320 LLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLG 386
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
53-189 |
3.94e-05 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 45.43 E-value: 3.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 53 TAFYFGYALTVLPGGLLAD-RFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAE 131
Cdd:cd17378 40 SSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEPVGPK 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1011507046 132 QRGTAVGIFMSCTSFGITVVNGYAPFvaVHYGWQMAFLITALLPLLVFFLALFTVKEV 189
Cdd:cd17378 120 WRGQVGMSTFFFFVLGFMSLPGIAYL--NGSSWRVLYFWTSIPALIYCILVYLFARRL 175
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
67-186 |
4.50e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 45.33 E-value: 4.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 67 GLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSF 146
Cdd:cd17391 261 GKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYL 340
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1011507046 147 GITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTV 186
Cdd:cd17391 341 GNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
31-183 |
5.22e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.85 E-value: 5.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 31 SSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLrFLLG 110
Cdd:cd17478 215 TTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAG 293
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1011507046 111 IVSGPVQSACLkAIGEHFSAEQRGTAVGIFMScTSFGI----TVVNGYapfVAVHYGWQMAFLITALLPLLVFFLAL 183
Cdd:cd17478 294 FLLFASFPVTV-VLAQELLPGNVGLASGLMMG-LSFGLggigAPVLGA---LADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
35-184 |
8.72e-05 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 44.13 E-value: 8.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 35 PIVNEALHFTAQQgTSYLTAfYFGYALTVLPG---GLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGI 111
Cdd:cd17331 232 LVAMDFFGLTPEE-NGYLMS-YAGVLGMVVQGllvGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVI 309
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1011507046 112 VSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALF 184
Cdd:cd17331 310 GGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
23-188 |
9.18e-05 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 44.49 E-value: 9.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 23 SFVMRLSWSS-----LMPIVNEALHFTAQQG---TSYLTafyFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMS 94
Cdd:cd17358 13 SFGIAVGWSSpalpsLMSDNSLSLPLTVAQFswfGSLLT---LGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 95 TVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAvhygWQMAFLItALL 174
Cdd:cd17358 90 FAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLP----WRTLALI-GAI 164
|
170
....*....|....
gi 1011507046 175 PLLVFFLALFTVKE 188
Cdd:cd17358 165 PPVVFLILLFFIPE 178
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
67-386 |
9.77e-05 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 44.21 E-value: 9.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 67 GLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYE--------YGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVG 138
Cdd:cd17367 61 GRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYAtigiwapiILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSS 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 139 IFMSCTSFGITVVNGYApFVAVH---------YGWQMAFLITALLPLLVFFLALfTVKEVQAFRKnhtvEVQGTEPRCMS 209
Cdd:cd17367 141 FQYVTLIGGQLLALGVL-LVLQHtlgedqmaaWGWRIPFLLGGVLAVVVLWLRR-GLEETESFEA----IAESNEASAGT 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 210 LAQSLRFVGTnrnilLLAVMGFFATGTTWGVTTWANL--YLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRIS-- 285
Cdd:cd17367 215 LRELRRHPRE-----LLLVVGLTAGGTLAFYTWTTYLqkFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGrr 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 286 ---LPRNYLAAIVMFlfsPALLIFANTTNPDML--YITAPLLGMGAfmYSPLTNAIIIQAAPPELRGTTAGF-VNLFNQI 359
Cdd:cd17367 290 pllLFFGIGGTLATV---PLLSALDHTDSPYTAfaLVLVGLVFLSG--YTSINAVVKAELFPTHVRALGVGLpYALAVAI 364
|
330 340 350
....*....|....*....|....*....|...
gi 1011507046 360 GALTAPIILsTVLTATGN------YQTALMALS 386
Cdd:cd17367 365 FGGTAPYVA-LWLKSIGHewvffwYVAGLIAIS 396
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
31-184 |
1.30e-04 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 43.68 E-value: 1.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 31 SSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLG 110
Cdd:cd17372 19 SFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVG 98
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1011507046 111 I-VSGPVQSACLKAigEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMaFLITALLPLLVFFLALF 184
Cdd:cd17372 99 LgLGGGPQLASWYL--EFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRW-LLAFSSVPSSLLLVFYR 170
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
54-184 |
1.47e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 43.80 E-value: 1.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 54 AFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMST---VQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSA 130
Cdd:pfam00083 54 IFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAakgKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPK 133
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1011507046 131 EQRGTAVGIFMSCTSFGITVvnGYAPFVAVHY-----GWQMAFLITALLPLLVFFLALF 184
Cdd:pfam00083 134 KLRGALGSLYQLAITFGILL--AYIFGLGLNKtsnsdGWRIPLGLQLVPALLLIIGLLF 190
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
52-188 |
1.55e-04 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 43.87 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 52 LTAFYFGYALTVLPGGLLADRFGYRKSILGS---LVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHF 128
Cdd:TIGR00879 77 VSIFLVGGFIGALFAGWLSDRFGRKKSLLIIallFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIA 156
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1011507046 129 SAEQRGTAVGIFMSCTSFGITV---VNGYAPFVAVHYGWQMAFLITALLPLLvFFLALFTVKE 188
Cdd:TIGR00879 157 PKALRGALTSLYQLAITFGILVaygFGSGKVSLNNTLGWRIPLGLQLIPAGL-LFLGLFFLPE 218
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
53-361 |
1.67e-04 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 43.46 E-value: 1.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 53 TAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYE--YGLVLRFLLGIVSGPVQSA---CLKAI-GE 126
Cdd:cd17342 70 TIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLhfYNKYLYCILWVLNGLLQSTgwpCVVAImGN 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 127 HFSAEQRGTAVGIFMSCTSFGitvvNGYAPFVA---VHYGWQMAFLITALLPL---LVFFLALFTvkevqafrknhtvev 200
Cdd:cd17342 150 WFGKSSRGFVLGLWSACASVG----NIIGALLAssvLDYGYEYAFLVTSSLLFagaIVVFFGLLS--------------- 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 201 QGTEPRCMSLAQSLrfvgtnrniLLLAVMGFFATGTtwgvttwanLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFI 280
Cdd:cd17342 211 SPPGVIPYSLAYAC---------LKLVNYSFFFWLP---------FYLSNNFHWKESEADQLSIWYDVGGIIGGIVAGYI 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 281 SDRISlPRNYLAAIVMFLFSPALLIFANTtnPDMLYITAPLLGMGAFMYSPLTNAI--IIQA---APPELRG------TT 349
Cdd:cd17342 273 SDRMG-SRSPVVVVMLLLAIPSLFVYSHS--PSDKVLNAFVMTITGFFIGGPANLIssAISAdlgRQPQLRGssealaTV 349
|
330
....*....|..
gi 1011507046 350 AGFVNLFNQIGA 361
Cdd:cd17342 350 TGIIDGTGSIGA 361
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
46-398 |
1.69e-04 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 43.43 E-value: 1.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 46 QQGTSYLTAFYFGYALTV--LPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKA 123
Cdd:cd17374 33 SQSLKSVAQSIFMAGLLVgaLIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLIL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 124 IGEHFSAEQRGTAVGIFMSCTSFGITVVNGYApFVAVHygWQMAFLITALLPLLVFFLALFTVKEVQAFrknhtvevqgt 203
Cdd:cd17374 113 GTEWTTPRHRALAITLTSCFFSIGQMLLAGLA-YAIRD--WRLLQLVVSVPFFLFFLYSWWLPKRTLIL----------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 204 epRCMSLAQSLRFVGTNRNILLLAVmgffatgttwgvttwaNLYLvkqlhvTPIFAGAIMSiygIAAVIAKPTIGFISDR 283
Cdd:cd17374 179 --SFVWFANSFSYYGLSLDLQHLGL----------------NVFL------LQFLFGAVEV---PARCLALFLLNHMGRR 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 284 ISLprnylaaiVMFLFSPALLIFANTTNP-DMLYITAPLLGMGAFMYSPLTNAIIIQAA---PPELRGTTAGFVNLFNQI 359
Cdd:cd17374 232 ISQ--------AVLLLLAGLCILANIFVPqEMQTLRTVLAVLGKGSSAAAFTISYVYTAelfPTVLRQTGMGLNSMFARI 303
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1011507046 360 GALTAPIILStvltaTGNYQTALMALS--ISPIIGAILLSL 398
Cdd:cd17374 304 GGILAPLIML-----LGVYSPLLPMIIygVLPILAGLLALL 339
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
36-376 |
1.90e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 43.36 E-value: 1.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 36 IVNEALHFTAQQGT-SYLT------AFYFGYALTV-----LPGGLL----ADRFGYRKSILGSLVAMAIVTGLMSTVQSY 99
Cdd:cd17331 9 IVLYATCYWLQQPVlPYLTkklgvdSVVFGYLQTTfsvlqLVGGPLfgrfGDLFGPRAALVLSFLSSALSYLLLAFASSV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 100 eYGLVLRFLLGIVSGPVQSACLkAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVF 179
Cdd:cd17331 89 -PMLFLSRLPSVFMHAMQAAQM-VVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 180 FLALFTVKEVQAFRKNHTVEVQGTEPRCMSLAQSLRFVGTnRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFA 259
Cdd:cd17331 167 VLVILLIPSNTKSKREKEAKESASPPSVFNLKEILRLLRL-PGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEEN 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 260 GAIMSIYGIAAVIAKP-TIGFISDRISLPRNYLAAIVMFLFSPALLIFAnTTNPDMLYITAPLLgMGAFMYSPLTNAIII 338
Cdd:cd17331 246 GYLMSYAGVLGMVVQGlLVGPLTKRFGERSLLKLSVALLAIGYLLLAFV-TTVWQLLVLLLPLV-IGGSVLYTVITSLLT 323
|
330 340 350
....*....|....*....|....*....|....*...
gi 1011507046 339 QAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATG 376
Cdd:cd17331 324 KAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYG 361
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
244-402 |
2.52e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.99 E-value: 2.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 244 ANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISlPRNYL----AAIVMFLFSPALLIFANTTNPDMLYITA 319
Cdd:cd06173 21 ALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFD-RRRLLiladLLRALLAAVLALLALLGSLSLWLLLVLA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 320 PLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIiLSTVLTATGNYQTALMALSISPIIGAILLSLI 399
Cdd:cd06173 100 FLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPA-LGGLLVALLGPGGAFAINALSFLLSALLLLFI 178
|
...
gi 1011507046 400 RLK 402
Cdd:cd06173 179 RRP 181
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
248-367 |
2.55e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 42.95 E-value: 2.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 248 LVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFANTTNpdMLYITAPLLGMGAF 327
Cdd:cd17503 22 IMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLA--SLIIFRILQGFGGG 99
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1011507046 328 MYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPII 367
Cdd:cd17503 100 VLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTL 139
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
250-401 |
2.72e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 42.99 E-value: 2.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 250 KQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISlpRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMY 329
Cdd:cd17328 27 SDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYN--RKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASY 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1011507046 330 SPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMalsISPIIGAILLSLIRL 401
Cdd:cd17328 105 SPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFR---VTGVLGVLLAILLLL 173
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
219-401 |
2.78e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 42.92 E-value: 2.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 219 TNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRnyLAAIVMFL 298
Cdd:COG0738 5 NYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKR--GLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 299 FSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIqAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGN- 377
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVA-ALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSl 161
|
170 180
....*....|....*....|....*
gi 1011507046 378 -YQTALMALSISPIIGAILLSLIRL 401
Cdd:COG0738 162 sWHLPYLILAVLLLLLALLFLRSKL 186
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
35-183 |
3.13e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.41 E-value: 3.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 35 PIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSIL-GSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVS 113
Cdd:cd06174 228 LFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLlIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGL 307
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 114 GPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAV-HYGWQMAFLITALLPLLVFFLAL 183
Cdd:cd06174 308 GGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAILLL 378
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
56-192 |
3.35e-04 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 43.04 E-value: 3.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 56 YFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGT 135
Cdd:TIGR01299 212 YLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGE 291
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1011507046 136 AVGIFMSCTSFGITVVNGYAPFVAVHYGW--QMA----------FLITALLPLLVFFLALFTVKEVQAF 192
Cdd:TIGR01299 292 HLSWLCMFWMIGGIYAAAMAWAIIPHYGWsfQMGsayqfhswrvFVIVCAFPCVFAIGALTFMPESPRF 360
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
65-372 |
3.46e-04 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 42.99 E-value: 3.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 65 PGGLLADRFGYRKSILGSLVAMAIVTGLM--STVQSYEYGL-VLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFM 141
Cdd:PRK08633 66 PAGFLADKFSKNRVIRIVKLFEVGLTLLIvlAYYLGWFWLAfAVTFLLGAQSAIYSPAKYGIIPELVGKENLSRANGLLE 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 142 SCTSFGITVVNGYAPFVA-VHYGWQMAFLITALLPLLVFFLALFTVKEVQAFRKNHTVEVQGTEP------RCMSLAQSL 214
Cdd:PRK08633 146 AFTIVAILAGTALFSFLFeSVNGNTPSEILGRIAPAGLVLLAVAVLGLIFAYRLPKVPAAAPEVFdkkkylFPKLLWRNL 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 215 RFVGTNRNILLlAVMGFfATGTTWGVTTWANL--YLVKQLHVTPIF-AGAIMSIYGIAAVIAKPTIGFIS-DRISLPRNY 290
Cdd:PRK08633 226 KLLRSDRVLWL-AIIGL-SYFWFISQLAQANFpaYAKEVLGLDNTFqVQYLLAASAIGIGIGSLLAGRLSgRHIELGLVP 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 291 LAAIVMFLFspaLLIFANTTNPDMLYITAPLLGMGAFMYS-PLtNAIIIQAAPPELRGTTAGFVNLFNQIGALTApIILS 369
Cdd:PRK08633 304 LGALGLALS---LFLLPTAPSLASVLVLFFLFGFSAGLFIvPL-NALIQFRAPEKELGKVLAANNFLQNVGMLLF-LALT 378
|
...
gi 1011507046 370 TVL 372
Cdd:PRK08633 379 TLF 381
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
32-383 |
3.89e-04 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 42.25 E-value: 3.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 32 SLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGI 111
Cdd:cd17476 19 VILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 112 VSGPVQSACLKAIGEHFS-AEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTvkevq 190
Cdd:cd17476 99 GPAFLLPNAMALLGRTYPpGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAAIFW----- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 191 afrknhtvevqgteprcmslaqslrfvgTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAA 270
Cdd:cd17476 174 ----------------------------TSPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 271 VIAKPTIGFISDRIslPRNYLAAIVMFLFSPALLIFAnTTNPDMLYITAPLLGM-----GAFMYSPLTNAIIIQAAPPEL 345
Cdd:cd17476 226 VLAAITVGFLIARL--PPSYIMAISMVAFLVGPILFA-TMPVHQTYWAQAFPAMivapfGMDFSFPAATIIASNAVPREY 302
|
330 340 350
....*....|....*....|....*....|....*...
gi 1011507046 346 RGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALM 383
Cdd:cd17476 303 QGLAGSLVNTVVNYGISIGLGIAGTVETSVNEDGADLL 340
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
28-400 |
4.08e-04 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 42.39 E-value: 4.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 28 LSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSIL--GSLVAMAIVTGLMSTVQSYEYG-LV 104
Cdd:cd17334 21 ITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLigAALNALGSVLKCIPLGQQPKFAlLV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 105 LRFLLGIVSGP-VQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVA-----VHYGWQMAFLITALLPLLV 178
Cdd:cd17334 101 LGQVLNALAQVlVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAIGFLLPPVVVpppkgTKKEFGAVFYGEFGFACLL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 179 FFLALFTVKEVQAFRKNHT-VEVQGTEPRCMSLAQSLRFVGTNRNILLLAV-----MGFFATGTTWGVTtwanlyLVKQL 252
Cdd:cd17334 181 LALVLALFPPKPKYPPSAAsARQQNSEHVILELQKSISELLRNEPFVLLAVafsimMGVFAGFSSVLAQ------ILLPF 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 253 HVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNY---LAAIVMFLFSPALLIFANTTNPD---MLYITAPLLGMGA 326
Cdd:cd17334 255 GVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRTRMFKLIgliILALGTVVCTFFMLLVDRYGLPYvtlAFYLLCGLLGFFQ 334
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1011507046 327 FMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMaLSISPIIGAILLSLIR 400
Cdd:cd17334 335 NSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSELLGPTPTESKYLL-WFILCTVGSCLGALFF 407
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
67-385 |
5.74e-04 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 41.83 E-value: 5.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 67 GLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGpVQSACLKAIGEHFSAEQRGTAVGIFMSCTSF 146
Cdd:cd17390 52 GSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKH-TQSLCKAYLSDLVSEQERSRVLGRFNAASSL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 147 GITV---VNGYapFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVQAFRknhtvevqgteprcmslaqSLRFvgtnrnI 223
Cdd:cd17390 131 GFILgpvVGGH--LAETDGGFYYVALLCSAIFILNAGLVWFLLSKLWDLL-------------------LVRF------L 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 224 LLLAVMGFFATGTtwgvttwanLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRIslPRNYLAAIVMFLFSPAL 303
Cdd:cd17390 184 MGFSVLLFRSNFS---------LYLEERFDLSPKTIGYLISYSGVLGALSGFLVGRILKLY--KNNEYLLLLHSFILLAL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 304 LIFanttnpdmLYITAPLLGMGAFMYSPL----------TNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPI---ILST 370
Cdd:cd17390 253 SLL--------GLALAPSIWLLVLCLTPLsissavlrtcSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLlsgLLQE 324
|
330
....*....|....*
gi 1011507046 371 VLTATGNYQTALMAL 385
Cdd:cd17390 325 FSVSGPGLLGAVLAL 339
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
57-231 |
6.40e-04 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 41.55 E-value: 6.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 57 FGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTA 136
Cdd:PRK10473 49 AGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKV 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 137 VGIFMsctsfGIT-VVNGYAPFVA----VHYGWQMAFLITALLPLLVFFLALFTVKEVQAFRK--NHTVEVQGTEP---- 205
Cdd:PRK10473 129 LSLLN-----GITcIIPVLAPVLGhlimLKFPWQSLFYTMAAMGILVLLLSLFILKETRPARApaASSKPRENSESllnr 203
|
170 180 190
....*....|....*....|....*....|....
gi 1011507046 206 --------RCMSLAQSLRFVGTNrNILLLAVMGF 231
Cdd:PRK10473 204 fflsrlviTTLSVTVILTFVNTS-PVLLMEQMGF 236
|
|
| MFS_MFSD1 |
cd17340 |
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily ... |
246-398 |
6.50e-04 |
|
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4). The function of MFSD1 is still unknown. Its expression is affected by altered nutrient intake. During starvation, expression of MFSD1 is downregulated in anterior brain sections in mice while it is upregulated in the brainstem. In mice raised on high-fat diet, MFSD1 is specifically downregulated in brainstem and hypothalamus. MFSD1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340898 [Multi-domain] Cd Length: 394 Bit Score: 41.49 E-value: 6.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 246 LYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISlpRN---YLAAIVMFLFSPALLIFANtTNPdmlYITAPLL 322
Cdd:cd17340 242 VFFEEKYGFSPSEAAAVNSIVYIISAAASPVFGFLVDKVG--RNilwVLIALVITLLGHLLLAFTF-VNP---LIAMVIM 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 323 GMGafmYSPLTNAI---IIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTA---LMALSISPIIGAILL 396
Cdd:cd17340 316 GIG---YSMLACALwpmVPLVVPEHQLGTAYGFMQSIQNLGLAVFPIIAGSILDKKGYLLLEvffIACLCVSLIALIILY 392
|
..
gi 1011507046 397 SL 398
Cdd:cd17340 393 LV 394
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
34-188 |
9.41e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 41.05 E-value: 9.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 34 MPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIvS 113
Cdd:PRK11102 14 LPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGL-A 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 114 GPVQSACLKAI-GEHFSAEQrgtavgiFMSCTSFgITVVNGYAPFVA--------VHYGWQMAFLITALLPLLVFFLALF 184
Cdd:PRK11102 93 AAAASVVINALmRDMFPKEE-------FSRMMSF-VTLVMTIAPLLApiiggwllVWFSWHAIFWVLALAAILAAALVFF 164
|
....
gi 1011507046 185 TVKE 188
Cdd:PRK11102 165 FIPE 168
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
246-326 |
1.01e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 40.99 E-value: 1.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 246 LYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRIsLPRNYLAAIVMFLFSPALLIFANTTNPDMLYITA-PLLGM 324
Cdd:cd17471 21 LFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRG-GDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGvVLLSL 99
|
..
gi 1011507046 325 GA 326
Cdd:cd17471 100 GA 101
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
260-399 |
1.09e-03 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 41.17 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 260 GAIMSIYGIAAVIAKPTIGFISDRISLpRNYLAAIVMFLFSPALLI--FANTTNPDMLYITAPLLGMGAFMYSPLTNAII 337
Cdd:TIGR00879 74 GLVVSIFLVGGFIGALFAGWLSDRFGR-KKSLLIIALLFVIGAILMglAAFALSVEMLIVGRVLLGIGVGIASALVPMYL 152
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1011507046 338 IQAAPPELRGTTAGFVNLFNQIGALTAPII--LSTVLTATGNYQTALMALSISPIIGAILLSLI 399
Cdd:TIGR00879 153 SEIAPKALRGALTSLYQLAITFGILVAYGFgsGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFL 216
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
57-188 |
1.21e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 40.63 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 57 FGYALTVLPGGLLADRFGYRKSILGSLV---AMAIVTGLMSTVQSYeygLVLRFLLGIVSGPVQSACLKAIGEHFSAEQR 133
Cdd:cd17359 47 LGAAIGALFAGRLADRFGRRKTLLISAVlffISALGSAFSPNFTIF---IIARIIGGLAVGGASALVPMYIAEVAPAEIR 123
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1011507046 134 GTAVGIFMSCTSFGITVV--------NGYAPFVAVHYGWQMAFLItALLPLLVFFLALFTVKE 188
Cdd:cd17359 124 GRLVSLNQLMIVFGQLLAyivnyliaNAGGADWLGAEGWRWMLGL-EAIPAILFLLGMLFIPE 185
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
56-192 |
1.53e-03 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 40.68 E-value: 1.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 56 YFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGT 135
Cdd:cd17438 44 YLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGE 123
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 136 AV----------GIFMSCTSFGITVVNGYAPFVAVHY---GWQMaFLITALLPLLVFFLALFTVKEVQAF 192
Cdd:cd17438 124 HLswlcmfwmigGLYASAMAWSIIPHYGWGFSMGTNYhfhSWRV-FVIICALPCIASIIALKFMPESPRF 192
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
57-184 |
1.66e-03 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 40.33 E-value: 1.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 57 FGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGpVQSACLKA-IGEHFSAEQRGT 135
Cdd:cd17360 46 AGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVG-IASMTVPLyIAEAAPPRIRGR 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1011507046 136 AVGIFMSCTSFGITVVNGY-APFVAVHYGWQMAFLITALLPLLVFFLALF 184
Cdd:cd17360 125 LVTINVLFITGGQFVAYVInGAFSYLPGGWRWMLGLAAVPAVLQFIGLLF 174
|
|
| MFS_FucP_like |
cd17394 |
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ... |
33-111 |
1.73e-03 |
|
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340952 [Multi-domain] Cd Length: 401 Bit Score: 40.28 E-value: 1.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 33 LMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGL---MSTVQSYEYGLVLRFLL 109
Cdd:cd17394 21 LIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALLfipAASLRTYGLFLIALFVL 100
|
..
gi 1011507046 110 GI 111
Cdd:cd17394 101 AS 102
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
223-400 |
1.79e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.22 E-value: 1.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 223 ILLLAVMGFFATGTTWGVTTWANLYLVkQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLpRNYLAAI--VMFLFS 300
Cdd:cd17370 1 VWLLGLVSLFADISYEMARSILPLFLV-VLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGK-RKPLVILgyGLSALA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 301 PALLIFANTTNPDMLYITAPLLGMGafMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTAT-GNYQ 379
Cdd:cd17370 79 KPLLALAGSWQLVLLLRILERLGKG--IRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLgGNYR 156
|
170 180
....*....|....*....|.
gi 1011507046 380 TALMALSISPIIGAILLSLIR 400
Cdd:cd17370 157 TIFLLAAIPALLALLILLFVV 177
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
52-184 |
2.03e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 39.85 E-value: 2.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 52 LTAFYFGYALTVLPGGLLADRFG-YRKSILGSLVAMAIVTGLMSTV---QSYEYGLVLRFLLGIVSGPVQSACLKAIGEH 127
Cdd:cd17502 209 LLPLIIGLVIGSIISGALISKTGrYKPLIVIGTILMSVGAGLLTTLtldTSKWLLIGYLILLGLGLGIGFQQPLVAVQNA 288
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1011507046 128 FSAEQRGTAVGIFMSCTSFGITVvngyapFVAVHYgwqmAFLITALLPLLVFFLALF 184
Cdd:cd17502 289 VPPADVGVATATNTFFRSLGGTL------GVAITD----VFLVALALAALAFLLSLF 335
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
41-191 |
2.18e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 39.88 E-value: 2.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 41 LHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFL--LGIVSGPVqs 118
Cdd:PRK11043 36 LQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVqaVGVCSAAV-- 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 119 aCLKAI-GEHFSAEQrgtAVGIFMSctsfgITVVNGYAP--------FVAVHYGWQMAFLITALLPLLVFFLALFTVKEV 189
Cdd:PRK11043 114 -IWQALvIDRYPAQK---ANRVFAT-----IMPLVALSPalapllgaWLLNHFGWQAIFATLFAITLLLILPTLRLKPSK 184
|
..
gi 1011507046 190 QA 191
Cdd:PRK11043 185 KA 186
|
|
| MFS_GLUT10_Class3 |
cd17436 |
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
31-195 |
2.22e-03 |
|
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340994 [Multi-domain] Cd Length: 376 Bit Score: 39.78 E-value: 2.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 31 SSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLG 110
Cdd:cd17436 21 SGALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLAGSFFWLVIGRAVVG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 111 IVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVvnGYA---PFVAVHYGWQMAFLITALLPLLVFFLALF--T 185
Cdd:cd17436 101 FAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILI--SYAlnyFFSNVLTGWRYMFGLAIIPAAIQFASILLlpK 178
|
170
....*....|
gi 1011507046 186 VKEVQAFRKN 195
Cdd:cd17436 179 KPEVLNIKDN 188
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
35-397 |
3.54e-03 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 39.29 E-value: 3.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 35 PIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFL--LGIV 112
Cdd:TIGR00710 29 PEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVqaFGAS 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 113 SGPVQSACLkaIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVQAF 192
Cdd:TIGR00710 109 AGSVISQAL--VRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLPY 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 193 RKNHTVEVQGTEprCMSLAQSLRFVGTnrnilLLAVMGFFAtgTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVI 272
Cdd:TIGR00710 187 EARIQISTYFET--FLLLLKSKMFWGY-----ALIYGASFG--GFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIF 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 273 AKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFANTTNPD---MLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTT 349
Cdd:TIGR00710 258 GGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGswaMIIGPMMFVGIGNSMISSIAMAYALEDFPHVAGTAS 337
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1011507046 350 AGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILLS 397
Cdd:TIGR00710 338 ALFGTLRLVLGAIVGYLVSLIHGNTAWPMSLSCLVLAVVSVLAFYYLS 385
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
219-402 |
3.80e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 39.12 E-value: 3.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 219 TNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLP----RNYL--A 292
Cdd:COG2211 8 SLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrrRPWIliG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 293 AIVMFLFSPALLI---FANTTNPDMLYITAPLLGMG-AFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIIL 368
Cdd:COG2211 88 AIPLALSFVLLFTapdLSPTGKLIYALVTYLLLGLAyTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLP 167
|
170 180 190
....*....|....*....|....*....|....*...
gi 1011507046 369 STVLTATGNYQ----TALMALSISPIIGAILLSLIRLK 402
Cdd:COG2211 168 PPLVAAFGGDAalgyRLTALIFAVLGLLAFLLTFFGTK 205
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
55-188 |
4.60e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 39.17 E-value: 4.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 55 FYFGYALTVLPGGLLADRFGYRKSILGSLVAM---AIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAE 131
Cdd:cd17357 58 FFIGGAIGSFISAFLANRFGRKNGLLISNALLvvsSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSE 137
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1011507046 132 QRGTAVGIFMSCTSFGITVVNGYA-PFV-AVHYGWQMAFLITAlLPLLVFFLALFTVKE 188
Cdd:cd17357 138 LRGALGSLTQIGVTLGILLGQVFGlPSVlGTETLWPYLLFFPG-IPALLQLAALPFFPE 195
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
39-183 |
4.63e-03 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 39.01 E-value: 4.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 39 EALHFTAQQGTSYLTAFY-FGYALTVLPG----GLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVS 113
Cdd:cd17363 320 CGCHLNDDEENAYLIYLVsFLGSLSVLPGnivsALLMDKIGRLKMIGGSMLLSAVCCFFLFFGNSESAMIGLQCLFCGVS 399
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 114 GPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNG-YAPFVAvhygwqmaflITALLPLLVFFLAL 183
Cdd:cd17363 400 IAAWNALDVVTVELYPTDKRATAFGFLNGLCKLAAILGNSiFGSFVG----------ITKVIPILLASAAL 460
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
228-367 |
4.77e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 38.69 E-value: 4.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 228 VMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFA 307
Cdd:cd17321 2 LLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 308 NttNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPII 367
Cdd:cd17321 82 P--SLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLL 139
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
64-401 |
5.75e-03 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 38.96 E-value: 5.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 64 LPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYG-----LVLRFLLGI---VSGPVQSAclkAIGEHFSAEQRGT 135
Cdd:pfam05977 63 IPAGALADNFDRRKIMLAGQLLLALVSTLLTLLAGLGLLspwllLGLTFLGGIgtaLMDPAWQA---SVPELVPRRDLPA 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 136 AVGIfmscTSFGITVVNGYAPFVAvhygwqmAFLITALLPLLVFFLA----LFTVKEVQAFRKNHTVEVQGTEPRCMSLA 211
Cdd:pfam05977 140 AVAL----NSVGYNIARSVGPALG-------GVLLAAFGPAFTFALNalsyFAVIAALWRWKRAAPASPLPRERIFGAVR 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 212 QSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYL 291
Cdd:pfam05977 209 AGLRFTAMSRELRSVLVRAFAFGLSASAVWALLPLVARDLLDGDAIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVL 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 292 AAIVMFLFSPALLIFAnttnpDMLYITAP--LLGMGAFMYSPLTNAIIIQAAPPE-LRGTT-AGFVNLFNqiGALTAPII 367
Cdd:pfam05977 289 LASVVTALVLLSLALA-----PNLWLAIPvlLLGGAAWITALTTLNVAVQLSVPRwVRGRAlAVYQTVFF--GGMAAGSW 361
|
330 340 350
....*....|....*....|....*....|....
gi 1011507046 368 LSTVLTATGNYQTALMALSISPIIGAILLSLIRL 401
Cdd:pfam05977 362 LWGAVAEALSVTGALLGAAAALLAGAAAGLRFRL 395
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
72-396 |
5.85e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 38.76 E-value: 5.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 72 RFGYRKS-ILGSLVAMAIVTGLMSTVQSYEYGL--------VLRFLLGIV-----SGPVQSACLKAIGEHFSAEQRGTAV 137
Cdd:cd17313 64 RIGRRRPfILVGAPLAALGLILIPNAADIGLALgdgprtwaLVLFVLGIVlldfaMNVCQGPVRALLPDLVPPEQRSKAN 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 138 GIFMSCTSFG----------ITVVNGYAPFVAVHYgwQMAFLITALLPLLVFFLALFTVKEVQaFRKNHTVEVQGTEPRC 207
Cdd:cd17313 144 GIINFMGGLGgvlgyllgaiLWDHNWFGFALGGNL--KVPFYIGAIILLVCVLVTLFFVKEPP-LSPEAGEHSENPSLGE 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 208 MSLAQSLRFVGTNRNILLLAV------MGFFATGTTWGVTTWANLYLVKQLHVTPI-----FAGAIMSIYGIAAVIAKPT 276
Cdd:cd17313 221 VLKSLLKLLKIMPRSLLRLLLviffwwIAFFPFELFFTDYMGEEVYHGTSAASSHYgagvrMGAWGLLIFSLAFLIFSLP 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 277 IGFISDRISLPRNYLAAIVMFLFSPALLIFanTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELR--GTTAGFVN 354
Cdd:cd17313 301 IGKLGKKIGRKKVYLIGLVLFAVGMALMAL--VHNVTVALVLFALGGIGWATININPYPLVSDYHSESGRgqGTDTGLLN 378
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1011507046 355 LFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILL 396
Cdd:cd17313 379 LAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGAL 420
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
24-159 |
6.04e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 38.73 E-value: 6.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 24 FVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQ--SYEY 101
Cdd:COG2211 242 LALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWL 321
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 102 GLVLRFLLGIVSGPVQS---ACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVA 159
Cdd:COG2211 322 LLVLAALAGIGLGAILVlpwAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALA 382
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
39-184 |
6.38e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 38.31 E-value: 6.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 39 EALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTV---QSYEYGLVLRFLLGIVSGP 115
Cdd:cd17321 197 GVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLgadSSVWLLLPGLVLLGLGLGL 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 116 VQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITV-----------------------VNGYAPFVAVHYGWQMAFLITA 172
Cdd:cd17321 277 FATPLTNAALSSVPKEKAGAASGILNTARQLGGALgvallgalltaglsanlgdsgvaALLSAAAAAFAAGFHLAFLVAA 356
|
170
....*....|..
gi 1011507046 173 LLPLLVFFLALF 184
Cdd:cd17321 357 ALALLAALLALL 368
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
43-181 |
6.92e-03 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 38.45 E-value: 6.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 43 FTAQQGTSYL----TAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLM-----STVQSYEYGLVLRFLLGIVS 113
Cdd:cd17344 55 FDGKNGTELLgaldSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFglgyyWNIHSLWYFVVVQILAGLFQ 134
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1011507046 114 GPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGiTVVNGYAPFVAVHYGWQMAF----LITALLPLLVFFL 181
Cdd:cd17344 135 STGWPSVVACVGNWFGKGKRGLIMGIWNSHTSVG-NILGSLIAGIFVSSAWGLSFivpgIIIAAMGVLVFLF 205
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
250-402 |
7.49e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.31 E-value: 7.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 250 KQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAivMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMY 329
Cdd:cd17477 24 EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAG--AAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGL 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1011507046 330 SPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATgnyQTALMALSISPIIGAILLSLIRLK 402
Cdd:cd17477 102 FVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAG---ALPFLIAAVLLLLALVPLLLTRRA 171
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
163-315 |
7.96e-03 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 38.39 E-value: 7.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 163 GWQMAFLITALLPLLVFFLALFTVKEVQ-AFRKNHTVEVqgteprcmSLAQSLRFVGTNRNILLLAVMgFFATGTTWGVT 241
Cdd:TIGR00792 171 GWFMFALVLALIGVVSLIICFFGTKERYsEIPKNIEKKL--------SLKQIFKALFKNDQLLILCLA-YLFYNLAFNIK 241
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1011507046 242 TWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFANTTNPDML 315
Cdd:TIGR00792 242 NGVQVYYFTYVLGDPELFSYMGSIAIVAGLIGVLLFPRLVKKFGRKILFAGGILLMVLGYLIFFFAGSNLPLIL 315
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
45-181 |
9.33e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 38.19 E-value: 9.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 45 AQQGtSYLTAFYFGYALTVLPGGLLADRFGYRKSIlGSLVAMAIVTGLMSTVQSYEYG---LVLRFLLGIVSGPVQSACL 121
Cdd:TIGR00894 76 ALQG-LILSSHFYGQIIIQIPVGYLAGKYVFKWSI-GIGMFLSSVISIVIPWAAGGGIalvVFCRVIQGLAQGSVSPATH 153
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 122 KAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHY-GWQMAFLITALLPLLVFFL 181
Cdd:TIGR00894 154 KIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWgGWPMIFYVFGIVGCAWSLL 214
|
|
| MFS_AmpG_like |
cd17486 |
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner ... |
126-328 |
9.35e-03 |
|
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341039 [Multi-domain] Cd Length: 387 Bit Score: 37.96 E-value: 9.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 126 EHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLpLLVFFLALFTVKEVQAFRKNHTVEVQGTEP 205
Cdd:cd17486 118 EALEDKEQGAGAGVRVNGYRIGMLVAGAGALYLADSLSWSAVYLIMAAL-MGPGILATLFAPEPPRTDPPANSLSETVVA 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 206 RCMSLAQslrFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIfaGAIMSIYGIAAVIAKPTI-GFISDRI 284
Cdd:cd17486 197 FFAPFKD---FFGQPGALLILAFILLYKLGDAMLGAMATPFLLDLGFTKTEI--GAVYKTVGLIATIVGGLLgGFLMSRL 271
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1011507046 285 SLPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPL--------LGMGAFM 328
Cdd:cd17486 272 GLKRSLWLFGILQALSNLGFIYLAHAGPNLTLLVAAVavenfgggLGTTAFV 323
|
|
|