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Conserved domains on  [gi|1011507046|ref|WP_062401530|]
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MULTISPECIES: MFS transporter [unclassified Veillonella]

Protein Classification

MFS transporter( domain architecture ID 11455192)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
23-400 1.72e-51

Sugar phosphate permease [Carbohydrate transport and metabolism];


:

Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 176.21  E-value: 1.72e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  23 SFVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYG 102
Cdd:COG2271    22 NYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQL 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 103 LVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLa 182
Cdd:COG2271   102 LLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL- 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 183 lftvkevqafrknhtvevqgteprcmslaqslrfvgtnrNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAI 262
Cdd:COG2271   181 ---------------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLL 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 263 MSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAP 342
Cdd:COG2271   222 LSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFP 301
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1011507046 343 PELRGTTAGFVNLFNQIGALTAPIILSTVLTATGnYQTALMALSISPIIGAILLSLIR 400
Cdd:COG2271   302 KKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLL 358
 
Name Accession Description Interval E-value
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
23-400 1.72e-51

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 176.21  E-value: 1.72e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  23 SFVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYG 102
Cdd:COG2271    22 NYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQL 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 103 LVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLa 182
Cdd:COG2271   102 LLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL- 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 183 lftvkevqafrknhtvevqgteprcmslaqslrfvgtnrNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAI 262
Cdd:COG2271   181 ---------------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLL 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 263 MSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAP 342
Cdd:COG2271   222 LSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFP 301
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1011507046 343 PELRGTTAGFVNLFNQIGALTAPIILSTVLTATGnYQTALMALSISPIIGAILLSLIR 400
Cdd:COG2271   302 KKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLL 358
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
23-396 1.71e-41

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 149.64  E-value: 1.71e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  23 SFVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYG 102
Cdd:cd17319    15 NYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSL 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 103 LVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLA 182
Cdd:cd17319    95 YVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLW 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 183 LFTVkevqafrknhtvevqgteprcmslaqslrfvgtnRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAI 262
Cdd:cd17319   175 WFYL----------------------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLL 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 263 MSIYGIAAVIAKPTIGFISDRIS-LPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAA 341
Cdd:cd17319   221 AAIPFLAGAIGMILGGRLSDRLLrGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLL 300
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1011507046 342 PPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILL 396
Cdd:cd17319   301 PGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLV 355
MFS_1 pfam07690
Major Facilitator Superfamily;
23-365 5.02e-30

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 118.29  E-value: 5.02e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  23 SFVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYG 102
Cdd:pfam07690   9 ALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 103 LVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLA 182
Cdd:pfam07690  89 LVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLL 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 183 LFTVKEVQAFRKNhtvevqGTEPRCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWAnlYLVKQLHVTPIFAGAI 262
Cdd:pfam07690 169 LLPRPPPESKRPK------PAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLP--LYQEVLGLSALLAGLL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 263 MSIYGIAAVIAKPTIGFISDRIS-LPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAA 341
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGrRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
                         330       340
                  ....*....|....*....|....
gi 1011507046 342 PPELRGTTAGFVNLFNQIGALTAP 365
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
24-376 4.02e-25

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 105.54  E-value: 4.02e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  24 FVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGL 103
Cdd:TIGR00881   8 YLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 104 VLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPF-VAVHYGWQMAFLITALLPLLVFFLA 182
Cdd:TIGR00881  88 ALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVFIVPGIIAIIVSLIC 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 183 LFTVKE---------VQAFRKNHTVEVQGTEPRCMSLAQS-LRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQL 252
Cdd:TIGR00881 168 FLLLRDspqscglppAEEMPNEEPDGDAEKKEEELTKKQIfLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEK 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 253 HVTPIFAGAIMSIYGIAAVIAKPTIGFISDRI-SLPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSP 331
Cdd:TIGR00881 248 GFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGP 327
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1011507046 332 --LTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATG 376
Cdd:TIGR00881 328 qmLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
67-376 1.37e-11

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 65.71  E-value: 1.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  67 GLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSAClKAIGEHFSAEQRGTAVGIFMSCTSF 146
Cdd:PRK09874   75 GGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNAN-ALIATQVPRNKSGWALGTLSTGGVS 153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 147 GITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKE-VQAFRKNHTVEVQgteprcmSLAQSLRfvgTNRNILL 225
Cdd:PRK09874  154 GALLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIREnFQPVSKKEMLHMR-------EVVTSLK---NPKLVLS 223
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 226 LAVMGFFATGTTWGVTTWANLY---LVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISlPRNYLaaIVMFLFSPA 302
Cdd:PRK09874  224 LFVTTLIIQVATGSIAPILTLYvreLAGNVSNIAFISGMIASVPGVAALLSAPRLGKLGDRIG-PEKIL--ITALIFSVL 300
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1011507046 303 LLI-FANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATG 376
Cdd:PRK09874  301 LLIpMSFVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYG 375
 
Name Accession Description Interval E-value
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
23-400 1.72e-51

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 176.21  E-value: 1.72e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  23 SFVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYG 102
Cdd:COG2271    22 NYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQL 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 103 LVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLa 182
Cdd:COG2271   102 LLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL- 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 183 lftvkevqafrknhtvevqgteprcmslaqslrfvgtnrNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAI 262
Cdd:COG2271   181 ---------------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLL 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 263 MSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAP 342
Cdd:COG2271   222 LSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFP 301
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1011507046 343 PELRGTTAGFVNLFNQIGALTAPIILSTVLTATGnYQTALMALSISPIIGAILLSLIR 400
Cdd:COG2271   302 KKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLL 358
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
23-402 1.16e-44

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 158.89  E-value: 1.16e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  23 SFVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYG 102
Cdd:COG2223    17 AFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLL 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 103 LVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLA 182
Cdd:COG2223    97 LLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLA 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 183 LFTVKEVQAFRKnhtvevQGTEPRCMSLAQSLRfvgtNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAI 262
Cdd:COG2223   177 WLFLRDPPAGAA------AAAKASLRDQLEALR----DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLL 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 263 MSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFAnTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAP 342
Cdd:COG2223   247 AALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALA-LGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFP 325
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 343 PELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILLSLIRLK 402
Cdd:COG2223   326 TKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRR 385
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
23-396 1.71e-41

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 149.64  E-value: 1.71e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  23 SFVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYG 102
Cdd:cd17319    15 NYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSL 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 103 LVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLA 182
Cdd:cd17319    95 YVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLW 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 183 LFTVkevqafrknhtvevqgteprcmslaqslrfvgtnRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAI 262
Cdd:cd17319   175 WFYL----------------------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLL 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 263 MSIYGIAAVIAKPTIGFISDRIS-LPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAA 341
Cdd:cd17319   221 AAIPFLAGAIGMILGGRLSDRLLrGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLL 300
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1011507046 342 PPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILL 396
Cdd:cd17319   301 PGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLV 355
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
30-400 4.48e-39

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 143.49  E-value: 4.48e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  30 WSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLL 109
Cdd:cd17325    15 IIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQ 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 110 GIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEv 189
Cdd:cd17325    95 GLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPE- 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 190 qafrknHTVEVQGTEPRCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIA 269
Cdd:cd17325   174 ------PRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLA 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 270 AVIAKPTIGFISDRIslPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTT 349
Cdd:cd17325   248 SALSQPPAGKLSDRI--GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTA 325
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 350 AGFVNLFNQIGALTAPiILSTVLTATGNYQTALMALSISPIIGAILLSLIR 400
Cdd:cd17325   326 MGLFNTAFSLGMVLGP-LLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
33-361 2.40e-37

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 138.57  E-value: 2.40e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  33 LMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIV 112
Cdd:COG2814    32 ALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLG 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 113 SGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVQAF 192
Cdd:COG2814   112 AGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPA 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 193 RKNHtvevqgteprcmsLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVI 272
Cdd:COG2814   192 ARAR-------------LRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVL 258
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 273 AKPTIGFISDRISLPRnyLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGF 352
Cdd:COG2814   259 GALLAGRLADRFGRRR--LLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGL 336

                  ....*....
gi 1011507046 353 VNLFNQIGA 361
Cdd:COG2814   337 YNSAFFLGG 345
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
33-397 2.51e-34

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 130.82  E-value: 2.51e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  33 LMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIV 112
Cdd:cd17475    18 LAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAG 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 113 SGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVQAF 192
Cdd:cd17475    98 YGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAA 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 193 RknhtvevqGTEPRCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVI 272
Cdd:cd17475   178 S--------AATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGAL 249
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 273 AKPTIGFISDRIsLPRNYLAAIVMFLFSPALLIFANTTNPD-----MLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRG 347
Cdd:cd17475   250 GRIGLGRVSDRV-FGGRRRPVLVITAAIAAAALLVLSLLSPgtplwLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAG 328
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1011507046 348 TTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILLS 397
Cdd:cd17475   329 TALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
MFS_1 pfam07690
Major Facilitator Superfamily;
23-365 5.02e-30

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 118.29  E-value: 5.02e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  23 SFVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYG 102
Cdd:pfam07690   9 ALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 103 LVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLA 182
Cdd:pfam07690  89 LVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLL 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 183 LFTVKEVQAFRKNhtvevqGTEPRCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWAnlYLVKQLHVTPIFAGAI 262
Cdd:pfam07690 169 LLPRPPPESKRPK------PAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLP--LYQEVLGLSALLAGLL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 263 MSIYGIAAVIAKPTIGFISDRIS-LPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAA 341
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGrRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
                         330       340
                  ....*....|....*....|....
gi 1011507046 342 PPELRGTTAGFVNLFNQIGALTAP 365
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
27-396 9.72e-30

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 118.30  E-value: 9.72e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  27 RLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLR 106
Cdd:cd06174    12 RGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGR 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 107 FLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVH--YGWQMAFLITALLPLLVFFLALF 184
Cdd:cd06174    92 FLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLL 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 185 TVKEVQafrknHTVEVQGTEPRCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMS 264
Cdd:cd06174   172 VVPDPP-----ESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLS 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 265 IYGIAAVIAKPTIGFISDRIsLPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPE 344
Cdd:cd06174   247 LFGLAGALGSLLLGLLSDRL-IGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPE 325
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1011507046 345 LRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILL 396
Cdd:cd06174   326 IRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
60-400 2.10e-25

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 106.12  E-value: 2.10e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  60 ALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGI 139
Cdd:cd17473    49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGL 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 140 FMSCTSFGITVVNGYAPFVAVhYGWQMAFLITaLLPLLVFFLALFTVKEVQAFRKNHTVEVQGTEPRCmslaqslrfvgT 219
Cdd:cd17473   129 QSAAMSLGGVVFLLLGGALAE-IGWRAPFLVY-LLALPVLILVLLFLPEPARKSKSAASPGAATAAAL-----------P 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 220 NRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISlpRNYLAAIVMFLF 299
Cdd:cd17473   196 WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLG--KRRLLAIGFALM 273
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 300 SPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQ 379
Cdd:cd17473   274 ALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLS 353
                         330       340
                  ....*....|....*....|.
gi 1011507046 380 TALMALSISPIIGAILLSLIR 400
Cdd:cd17473   354 GAFLILGVLALVLAIVLLLLR 374
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
24-376 4.02e-25

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 105.54  E-value: 4.02e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  24 FVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGL 103
Cdd:TIGR00881   8 YLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 104 VLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPF-VAVHYGWQMAFLITALLPLLVFFLA 182
Cdd:TIGR00881  88 ALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVFIVPGIIAIIVSLIC 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 183 LFTVKE---------VQAFRKNHTVEVQGTEPRCMSLAQS-LRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQL 252
Cdd:TIGR00881 168 FLLLRDspqscglppAEEMPNEEPDGDAEKKEEELTKKQIfLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEK 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 253 HVTPIFAGAIMSIYGIAAVIAKPTIGFISDRI-SLPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSP 331
Cdd:TIGR00881 248 GFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGP 327
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1011507046 332 --LTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATG 376
Cdd:TIGR00881 328 qmLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
30-398 6.13e-25

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 104.55  E-value: 6.13e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  30 WSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLL 109
Cdd:cd17324    18 IQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALA 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 110 GIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEV 189
Cdd:cd17324    98 GLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSL 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 190 QAFRKNHTvevqgteprcmSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIA 269
Cdd:cd17324   178 PPKKPGSL-----------GLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVA 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 270 AVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFANttNPDMLYITAPLLGMGAFMYSPLTNAIIIQAApPELRGTT 349
Cdd:cd17324   247 GVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGP--SPLLLLVGLVLWGLGFFAAHSALQTRVLRLA-PEARGLA 323
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1011507046 350 AGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSIspIIGAILLSL 398
Cdd:cd17324   324 SSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAAL--LLLALLLAL 370
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
23-395 1.13e-24

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 104.57  E-value: 1.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  23 SFVMRLSWSSLMPIVNE---ALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSY 99
Cdd:COG2807    27 ALNLRPAITSVGPLLPEiraDLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSV 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 100 EYGLVLRFLLGIVSGPVQSACLKAIGEHFsAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVF 179
Cdd:COG2807   107 ALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLAL 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 180 FLALFTVKEVQAFRKnhtvevqgteprcmSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANL--YLVkQLHVTPI 257
Cdd:COG2807   186 LLWLPLLRRRPAAAA--------------AAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLppILR-DAGLSAA 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 258 FAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAI-VMFLFSPALLIFANTTnpdMLYITAPLLGMGAFMYSPLTNAI 336
Cdd:COG2807   251 TAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLgLLGLAGLLGLLLAPGS---LPWLWAVLLGLGQGGLFPLALTL 327
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 337 IIQAAP-PELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAIL 395
Cdd:COG2807   328 IGLRARtPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVA 387
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
29-395 9.85e-23

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 98.77  E-value: 9.85e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  29 SWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFL 108
Cdd:COG0738    26 LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFL 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 109 LGIVSGPVQSACLkAIGEHFSAEQRGTAVGIFMSCTSFGITVVN---GYAPFVAVHYGWQMAFLITALLPLLVFFLALFT 185
Cdd:COG0738   106 LGLGLGLLDVAAN-PYVAALGPETAASRLNLLHAFFSLGALLGPllgGLLILLGLSLSWHLPYLILAVLLLLLALLFLRS 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 186 vkevqafrknHTVEVQGTEPRCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSI 265
Cdd:COG0738   185 ----------KLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSL 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 266 YGIAAVIAKPTIGFISDRISlpRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQaAPPEL 345
Cdd:COG0738   255 FWGGMTIGRFLGGFLLKRFG--PVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALD-GLGKR 331
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1011507046 346 RGTTAGFVNLFNQIGALTAPIILSTVLTATGnYQTALMALSISPIIGAIL 395
Cdd:COG0738   332 TAAAVSAVLIMGIVGGAIGPPLIGFLADAFG-LRAAFLVPLVCYLLILLL 380
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
24-400 1.13e-21

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 95.42  E-value: 1.13e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  24 FVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGL 103
Cdd:cd17312    16 YVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFA 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 104 VLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLAL 183
Cdd:cd17312    96 VLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILF 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 184 FTVKEvqafrknhtvevqgteprcmslaqslrfvgTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIM 263
Cdd:cd17312   176 FFLRD------------------------------SPPYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFS 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 264 SIYGIAAVIAKPTIGFISDRISL-PRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLgMGAFMYSP---LTNAIIIQ 339
Cdd:cd17312   226 SLYEVGGIAGTILAGLLSDKLFGgRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFL-IGFFVGGPinlIGGAAAQD 304
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 340 AAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGnYQTALMALSISPIIGAILLSLIR 400
Cdd:cd17312   305 IGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYG-WSTVFYFLISAALLSVLLLLSLW 364
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
27-400 2.58e-20

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 91.92  E-value: 2.58e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  27 RLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLR 106
Cdd:cd17345    19 RNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSATSSVGLM 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 107 FLLGIVSGPVQS----ACLKAIGEHFSAEQRGTAVGIFMSCTSFG---ITVVNGYAPFVAVHYGWQMAFLITALLPLLVF 179
Cdd:cd17345    99 FILLFLNGWFQGmgwpPSGRTMVHWFSKKERGTWTSIWNISHNVGgglVGPLAGLGLAIFGDGWWRGAFIFPAIIAIIVA 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 180 FLALFTVKE---------VQAFRKNHTVEVQG-TEPRCMSLAQSL-RFVGTNRNILLLAVMGFFATGTTWGVTTWANLYL 248
Cdd:cd17345   179 VIVLFLGKDtpeseglppIEEYKGDYPEEADGeEEEQELSAWEIFvKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYL 258
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 249 VKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVmFLFSPALLIFANTTNPDMLYITAPLLGMGAFM 328
Cdd:cd17345   259 SEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPTGII-FMILVIVALIVYWLAPNVLVDLIALIALGFLI 337
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1011507046 329 YSP--LTNAIIIQAAPPELRGTTAGFVNLFNQI-GALTAPIILSTVLTATGnYQTALMALSISPIIGAILLSLIR 400
Cdd:cd17345   338 YGPvmLIGLQALELVPKKAAGTAAGLTGLFGYLgGSVLATALIGIIVDHFG-WNGGFIVLLASCILAIIFLALVA 411
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
23-396 3.00e-20

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 91.52  E-value: 3.00e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  23 SFVMRLSWSSLMPIVneALHFTAQQGTSYLTAfyfGYALTVLP---------GGLLADRFGYRKSILGSLVAMAIVTGLM 93
Cdd:cd17329     8 SFLNRLGFFMVWPFM--AIYLHQQLGLSASIV---GLVLALSAvagivasliGGRLADRFGRKPVMLAGLLLRALGFALL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  94 STVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVhYGWQMAFLITAL 173
Cdd:cd17329    83 GFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 174 LPLLVFFLALFTVKEVQAFRKNHTVevqgteprcMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLH 253
Cdd:cd17329   162 LFLLAALVLLFLLPETRPKRRAAEK---------TEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILG 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 254 VTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVmfLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLT 333
Cdd:cd17329   233 LGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGIL--LFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAV 310
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1011507046 334 NAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIIlSTVLTATGNYQTALMALSISPIIGAILL 396
Cdd:cd17329   311 QTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLV-GGLLLDLLGPGLPWLILAALGLIAAALL 372
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
34-374 9.37e-20

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 89.92  E-value: 9.37e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  34 MPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVS 113
Cdd:cd17321    19 LPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGA 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 114 GPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLAlftvkevqafr 193
Cdd:cd17321    99 AAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA----------- 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 194 knhtvevqgteprcmslaqslrfvgtnRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIA 273
Cdd:cd17321   168 ---------------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVA 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 274 KPTIGFISDRISlPRnYLAAIVMFLFSPALLIFANTTNPDMLYITAP---LLGMGAFMYSPLTNAIIIQAAPPELRGTTA 350
Cdd:cd17321   221 APLAGRLADRFG-PR-LVLVAGLLLTAVGLLLLALLGADSSVWLLLPglvLLGLGLGLFATPLTNAALSSVPKEKAGAAS 298
                         330       340
                  ....*....|....*....|....
gi 1011507046 351 GFVNLFNQIGALTAPIILSTVLTA 374
Cdd:cd17321   299 GILNTARQLGGALGVALLGALLTA 322
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
53-395 3.52e-19

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 88.03  E-value: 3.52e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  53 TAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQ 132
Cdd:cd17489    38 GLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSR 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 133 RGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFtvkevqafRKNHTVEVQGTEPRCMSLAQ 212
Cdd:cd17489   118 RGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFL--------VKDPPPVAAEEAEAGTRAFR 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 213 SLRfvgtNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTpifAGAIMSIYGIAAVIAKPTIGFISDRisLPRNYLA 292
Cdd:cd17489   190 RLV----EKKVLPPALILFLASIAYGAISTFLPLYAAERGISN---AGLFFTVYAIALLLSRPFSGKLSDR--KGPKTVI 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 293 AIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVL 372
Cdd:cd17489   261 IPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVA 340
                         330       340
                  ....*....|....*....|...
gi 1011507046 373 TATGnYQTALMALSISPIIGAIL 395
Cdd:cd17489   341 ELFG-YRAMFLLAAVVVLLALVL 362
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
41-396 5.64e-19

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 87.27  E-value: 5.64e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  41 LHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSAC 120
Cdd:cd17316    31 LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGA 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 121 LKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVH----YGWQMAFLITALLPLLVFFLAlftvkevqafrknh 196
Cdd:cd17316   111 STYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLlsgdWGWRILFLIGALPALLALLLR-------------- 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 197 tvevqgteprcmslaqslrfvgtnRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPT 276
Cdd:cd17316   177 ------------------------RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALI 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 277 IGFISDRISLPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLF 356
Cdd:cd17316   233 AGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNL 312
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1011507046 357 NQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILL 396
Cdd:cd17316   313 GRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVA 352
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
44-400 6.17e-19

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 87.74  E-value: 6.17e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  44 TAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKA 123
Cdd:cd17371    32 DEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAAL 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 124 IGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVA----VHYGWQMAFLITALLPLLVFFLALFtVKEVQAFRKnHTVE 199
Cdd:cd17371   112 MAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFpllpPEIAWRVLFLLGALPALLVLFIRRF-VKEPPQWQA-ARAA 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 200 VQGTEPRcmsLAQSLRFVGTNRNILLLA-VMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIG 278
Cdd:cd17371   190 RRHFADR---PSLRELFSPPLLRTTLLAsLLATGALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGG 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 279 FISDRISLPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPlLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQ 358
Cdd:cd17371   267 FLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILILGFP-LGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGR 345
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1011507046 359 IGALTAPiILSTVLTATGNYQTALMALSISPIIGAILLSLIR 400
Cdd:cd17371   346 IIGALFP-FLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLL 386
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
31-398 3.56e-18

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 85.31  E-value: 3.56e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  31 SSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLG 110
Cdd:cd17474    19 DPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQG 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 111 IVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVvngyAPFVA---VHYGWQMAFLITALLPLLVFFLALFTVK 187
Cdd:cd17474    99 IGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAV----GPLLGgllAAISWRYPFFLLAALIPVAFLAILFLLP 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 188 EvqafRKNHTVEVQGTEPRCMSLAQslrfvgTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYG 267
Cdd:cd17474   175 E----PKEKAKSSSATKLRDLKKAL------RGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWS 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 268 IAAVIAKPTIGFISDRISLPRnYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRG 347
Cdd:cd17474   245 VLLALGSLFVGRLLKKRFGAR-RILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERG 323
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 348 TTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILLSL 398
Cdd:cd17474   324 TASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
60-399 8.45e-18

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 84.57  E-value: 8.45e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  60 ALTVLPGGLLAD----RFGYRKS-ILGSLVAMAIVTGLM------STVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHF 128
Cdd:COG2211    60 AITDPLIGALSDrtrtRWGRRRPwILIGAIPLALSFVLLftapdlSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELT 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 129 -SAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHY------GWQMAFLITALLPLLVFFLALFTVKEVQAFRKNHTvevq 201
Cdd:COG2211   140 pDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKV---- 215
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 202 gteprcmSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFIS 281
Cdd:COG2211   216 -------SLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLA 288
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 282 DRISLPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPEL-------RGTTAGFVN 354
Cdd:COG2211   289 KRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFT 368
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 355 LFNQIGALTAPIILSTVLTATG------NYQTALMALSISPIIGAILLSLI 399
Cdd:COG2211   369 FAIKLGQALAGALAGLLLALFGyvagaaQSPSALTGIRLLFFLLPAVLLLL 419
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
23-396 1.10e-17

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 83.86  E-value: 1.10e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  23 SFVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYeYG 102
Cdd:cd17355    15 SWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSL-WQ 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 103 LVLRFLLGIVSGPVQSA--CLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFF 180
Cdd:cd17355    94 LYLLWGLLGGGGAGTLAavAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLV 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 181 LALftvkevqAFRKNHTVEVQG---TEPRCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVkQLHVTPI 257
Cdd:cd17355   174 PVL-------LLLRRRPADLALrayDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLA-DRGISPA 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 258 FAGAIMSIYGIAAVIAKPTIGFISDRISLPRnyLAAIVMFLFSPALLIFANTTNPD-MLYITAPLLGMGAFMYSPLTNAI 336
Cdd:cd17355   246 AAAVALALIGLFNIVGRLLSGWLGDRYSPRR--LLAASYALRALGLALLLLLPFPPlALLLFAALFGLGWGATVPLTAAL 323
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 337 IIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILL 396
Cdd:cd17355   324 AARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLV 383
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
67-371 1.64e-17

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 83.47  E-value: 1.64e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  67 GLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVqSACLKAIGEHFSAEQRGTAVGIF----MS 142
Cdd:cd17391    57 GRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYV-PNATALIASQTPKEKSGWALGTLstgvVA 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 143 CTSFGITVvngyAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEvqafrkNHTVEVQGTEPRCMSLAQSLRFVGTnrn 222
Cdd:cd17391   136 GTLIGPLL----GGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKE------DFKPVEKKKMVSTKEVWNSVPNPSL--- 202
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 223 ILLLAVMGFFATGTTWGVTTWANLYlVKQLH----VTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIvmfL 298
Cdd:cd17391   203 LISLFVTTFIIQLANQSIEPILTLY-IRQLMgdasNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGAL---L 278
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1011507046 299 FSPALLIF-ANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTV 371
Cdd:cd17391   279 ASALLYIPqAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAI 352
MFS_SLC37A4 cd17343
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ...
27-400 5.89e-17

Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340901 [Multi-domain]  Cd Length: 409  Bit Score: 82.00  E-value: 5.89e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  27 RLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLR 106
Cdd:cd17343    19 RKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSVWVFSILW 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 107 FLLGIVSGPVQSACLKAIGEHFSAEQRGTavgiFMSCTSFGITVVNGYAPFVAV----HYGWQMAFLITALLPLLVFFLA 182
Cdd:cd17343    99 FLNGLAQGLGWPPCAKILRKWFSPSQFGT----WWSVLSTSMNLAGSLGPILATllalSYGWRSTLSISGTVAVVMSVVC 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 183 LFTVKEVQAFRknhTVEVQGTEPRCMSLAQSLRFVGTNRNILL--------LAVMGFFATGTTWGVTtwANLYLVKQLHV 254
Cdd:cd17343   175 LLFIKNEPSDV---GLNNIEEEESKGKKKKSPRGESTLKELLLspflwllsLGYLVVFGVKTAVTDW--GQLFLIQDKGQ 249
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 255 TPIFAGAIMSIYGIAAVIAKPTIGFISDRISL---------PRNYLAAIVMFLFSPALLIFANTTNPD--MLYITAPLLG 323
Cdd:cd17343   250 SALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAkhgsssrgnPRMPLALVFMAGLTVSLHLFRVHITSDssELFILLLGFL 329
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1011507046 324 MGAFMYSPLT--NAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATgNYQTALMALSISPIIGAILLSLIR 400
Cdd:cd17343   330 IGFSLYGPIAifGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHY-DWRTAFLLLEILCAITVVILFLLR 407
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
23-383 8.46e-17

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 81.14  E-value: 8.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  23 SFVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRK-SILGSLVAMAIVTGLMSTVQSYEY 101
Cdd:cd17341    11 GFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRvFIASLLLLLIPLLALALAVSSYWG 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 102 GLVLRFLLGIvSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAP-------FVAVHYGWQMAFLITALL 174
Cdd:cd17341    91 LLVLGFLLGF-AGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPliagaivFDGGFVGWRNAFFVPGIL 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 175 PLLVFFLALFtvkevqaFRKNHTvevQGTEPRCMSLAQsLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHV 254
Cdd:cd17341   170 LAIAAVLVLL-------FGDDLP---TGKASALEFLKV-QLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGL 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 255 TPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFANTTNPDMLYITApLLGMGAFMYSPLTN 334
Cdd:cd17341   239 PLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFL-ALFVALGLGAGAGN 317
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1011507046 335 AIIIQAAPPELR---GTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALM 383
Cdd:cd17341   318 GSVFRMVPFIFRrelGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFS 369
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
53-396 9.87e-17

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 81.13  E-value: 9.87e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  53 TAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQ 132
Cdd:cd17328    41 TVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEK 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 133 RGTAVGIFmsctSFGITV-------VNGYapFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVqafRKNHTVEVQGTEP 205
Cdd:cd17328   121 RTRALGVF----YFAIPLgsglgyvVGGL--VAQATGGWRWAFRVTGVLGVLLAILLLLFVREP---PRGAAEGGVMAKS 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 206 RCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAK----PTIGFIS 281
Cdd:cd17328   192 TATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGvlgvLLGGILA 271
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 282 DRISLPRN----YLAAIVMFLFSP--ALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNL 355
Cdd:cd17328   272 DRLRRKTPradpLVCAVGLLAAAPflFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQIL 351
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1011507046 356 FNQIGALTAPIILSTVLTATGNY------------QTALMALSISPIIGAILL 396
Cdd:cd17328   352 LSHLLGDAGSPYLIGLISDLLRQnkdsplaeaaslQYALLLCSFVLVLGGFFF 404
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
51-399 3.76e-16

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 79.20  E-value: 3.76e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  51 YLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLM-----STVQSYEYGLVLRFLLGIVSGPVQSACLKAIG 125
Cdd:cd06173    39 VLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLallalLGSLSLWLLLVLAFLLGIASAFFGPARQALLP 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 126 EHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVkevqafRKNHTVEVQGTEP 205
Cdd:cd06173   119 ELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIR------RPPPAAPGESSSL 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 206 RCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRis 285
Cdd:cd06173   193 LLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKR-- 270
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 286 LPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQiGALTAP 365
Cdd:cd06173   271 RRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNS-GAMPLG 349
                         330       340       350
                  ....*....|....*....|....*....|....
gi 1011507046 366 IILSTVLTATGNYQTALMALSISPIIGAILLSLI 399
Cdd:cd06173   350 ALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
44-401 1.09e-15

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 77.63  E-value: 1.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  44 TAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKA 123
Cdd:cd17365    32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITL 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 124 IGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTvkevqafrknhtvevqgt 203
Cdd:cd17365   112 VSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGT------------------ 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 204 eprcmslaqslrfvgtnrniLLLAVMgFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDR 283
Cdd:cd17365   174 --------------------LLLWVT-FFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADR 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 284 ISlPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALT 363
Cdd:cd17365   233 FG-PKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAIL 311
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1011507046 364 APIILSTVLTATGNYQTALMALSISPIIGAILLSLIRL 401
Cdd:cd17365   312 GPLLGGLLLAAGLGPESVFLALAIPAALGALAVLLLRL 349
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
24-401 1.97e-15

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 76.98  E-value: 1.97e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  24 FVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGL 103
Cdd:cd17333     9 GLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 104 VLRFLLGIVSGPVQSACLKAIGEHFSaEQRGTAVGIFMSCTSFGITVVNGYA-PFVAVHYGWQMAFLITALLPLLVFFLA 182
Cdd:cd17333    89 VLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIAtSLLTSELSWSWAYLIIGLIYLLLAILI 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 183 LFTVKEVQAFRKNHTVEVQGTEPrcmSLAQSLRfvgtNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAI 262
Cdd:cd17333   168 LLTLFPELPSARNPQQSVGAFSA---SASRLLR----NPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 263 MSIYGIAAVIAKPTIGFISDRIsLPRNYLAAIVmFLFSPALLIFANTTNPDMLYITAPLLGMGAfmySPLTNAIIIQAAP 342
Cdd:cd17333   241 LSGFWVGITIGRLLGGPISRRI-KPHTLLVLSG-SGALLGLLILLLAPTLVVGLVATALLGLFM---AALFPTILSLGIS 315
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 343 --PELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMAlsisPIIGAILLSLIRL 401
Cdd:cd17333   316 nlPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLI----TILYAIIFVLALL 372
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
54-400 3.99e-15

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 76.05  E-value: 3.99e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  54 AFYFGYALTVLPGGLLADRFGYRK-SILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAeQ 132
Cdd:cd17352    46 LLLGVSLFSGPLSSALVNRFGCRPvAIAGGLLAALGLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEK-K 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 133 RGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFlalftvkevqafrknhtvevqgteprCMSLAQ 212
Cdd:cd17352   125 RGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCV--------------------------CGLLLR 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 213 SLRfvgtNRNILLLAVMGFFATGTTWGVTTWANLYLvKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLA 292
Cdd:cd17352   179 LLK----DPTFVLLALGVSFAMLGFFVPFVYLPSYA-KSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLY 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 293 AIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVL 372
Cdd:cd17352   254 IFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLR 333
                         330       340
                  ....*....|....*....|....*...
gi 1011507046 373 TATGNYQTALMALSISPIIGAILLSLIR 400
Cdd:cd17352   334 DYTGDYDAAFYFCGACLLLSGVLLFLLP 361
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
27-395 6.52e-14

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 72.34  E-value: 6.52e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  27 RLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLR 106
Cdd:cd06180    15 RFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALR 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 107 FLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPF-VAVHYGWQMAFLITALLPLLVFFLALFT 185
Cdd:cd06180    95 FLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAgLGGGLSWRAGWLALALLSAVLLLLSFLL 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 186 VKEVqafrknhtvevqgtEPRCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYlVKQLHVTPIFAGAIMSI 265
Cdd:cd06180   175 LRRG--------------PSAPTEASAAESAPGLNRPLWRLALAYGLFGFGYIITATFLPLI-ARETGAGSLLAGLLWSL 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 266 YGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFANTtnPDMLYITAPLLGmGAFMYSPLTNAIIIQAAPPEL 345
Cdd:cd06180   240 FGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPG--PAGLVLSAVLFG-GTFMAITALVMALARELAPPA 316
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1011507046 346 RGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAIL 395
Cdd:cd06180   317 APRALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAALL 366
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
34-184 7.83e-14

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 71.38  E-value: 7.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  34 MPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVS 113
Cdd:COG0477    37 LPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGA 116
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 114 GPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALF 184
Cdd:COG0477   117 GGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLR 187
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
53-378 9.54e-14

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 71.82  E-value: 9.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  53 TAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQ 132
Cdd:cd17477    38 SAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNEN 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 133 RGTAVGIFMSCTSFGITVvnGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVQAFRKNHtvevqgteprcmslaq 212
Cdd:cd17477   118 RGRVLGLYSTVLGLGFAL--GPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEEAE---------------- 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 213 SLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVkQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLA 292
Cdd:cd17477   180 SISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGL-RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLG 258
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 293 AIVMFLFSPALLIFANTTNPdMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVL 372
Cdd:cd17477   259 CALLGALAALLLPLVPGLPL-ALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALM 337

                  ....*.
gi 1011507046 373 TATGNY 378
Cdd:cd17477   338 DAFGPH 343
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
39-391 2.12e-13

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 71.07  E-value: 2.12e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  39 EALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQS 118
Cdd:cd17503    24 GDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIP 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 119 ACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLItaLLPLLVFFLALFTVKEVQAFRknhtv 198
Cdd:cd17503   104 LAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYI--NLPIGILALLLAPLLDLRLFK----- 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 199 evqgteprcmslaqslrfvgtNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIG 278
Cdd:cd17503   177 ---------------------DRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVG 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 279 FISDRISLPRNYLAAIVMFLFSPALLIFAN-TTNPDMLYITAPLLGMG-AFMYSPLtNAIIIQAAPPELRGTTAGFVNLF 356
Cdd:cd17503   236 RLLDKFGPRLLLLAGLLLLALGTLLLAFLTpDTSLWLIILPLFIRGLGmGLVFMPL-NTLALNSLPPEQIGDATALFNTI 314
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1011507046 357 NQIGALTAPIILSTVLTATGNYQTALMALSISPII 391
Cdd:cd17503   315 RQLGGSIGTALLATLLTNRTQFHHSRLSELLAQQV 349
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
33-396 2.67e-13

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 70.66  E-value: 2.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  33 LMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIV 112
Cdd:cd17478    18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIG 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 113 SGPVQSACLKAIGeHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGwQMAFLITALLPLLVFFLALFTVKEVQAF 192
Cdd:cd17478    98 SAAFHPEGARLAS-QAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFG-GLGLLILLIIPGLAVALLLLRLRPLKKP 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 193 RKNHTVEVQgteprcmslAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVkQLHVTPIFAGAIMSIYGIAAVI 272
Cdd:cd17478   176 EAKKAAAKS---------SARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLV-QRGYSLVFAGLLLSLFLFAGAI 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 273 AKPTIGFISDRISlpRNYLAAIVMFLFSPALLIFANTTNPdMLYITAPLLGMGAFMYSPLTnAIIIQAAPPELRGTTAGF 352
Cdd:cd17478   246 GTLIGGPLSDRFG--RRRVIIASLLLAAPFLLLFLLTPGI-WSYILLVLAGFLLFASFPVT-VVLAQELLPGNVGLASGL 321
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1011507046 353 VNLFNQ-IGALTAPIIlsTVLTATGNYQTALMALSISPIIGAILL 396
Cdd:cd17478   322 MMGLSFgLGGIGAPVL--GALADAFGLESVLLILALLPLLGALLA 364
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
47-372 3.60e-13

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 70.46  E-value: 3.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  47 QGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGE 126
Cdd:TIGR00895  53 QLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSE 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 127 HFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKE----------VQAFRKNH 196
Cdd:TIGR00895 133 YAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPEsidflvskrpETVRRIVN 212
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 197 TVEVQGTEPRCMSLAQSLRFVGTNRNIL------------LLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMS 264
Cdd:TIGR00895 213 AIAPQMQAEAQSALPEQKSTQGTKRSVFkalfqgktaritVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGA 292
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 265 IYGIAAVIAKPTIGFISDRISlpRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPE 344
Cdd:TIGR00895 293 LFNFGGVIGSIIFGWLADRLG--PRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTA 370
                         330       340
                  ....*....|....*....|....*...
gi 1011507046 345 LRGTTAGFVNLFNQIGALTAPIILSTVL 372
Cdd:TIGR00895 371 IRATGVGWAIGIGRLGAIIGPILAGYLL 398
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
24-398 1.54e-12

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 67.99  E-value: 1.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  24 FVMRLSWSSLMPIVNealHFTAQQGTSYLTAFYFG-----YALTVLPG----GLLADRFGYRKSILGSLVAMAIVTGLMS 94
Cdd:cd17330     6 FLDALGFGIVFPVLP---FYVREFNKLGASGYYVGllqssYSLGQFLAsplwGRLSDRYGRKPVLLLSLAGSAVSYVLLG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  95 TVQSYEYGLVLRFLLGIVSGPVqSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALL 174
Cdd:cd17330    83 LSRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAAL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 175 PLLVFFLALFTVkevqafrknhtvevqgteprcmslaqslrfvgtnRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHV 254
Cdd:cd17330   162 ALLNLVLVLFFL----------------------------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGF 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 255 TPIFAGAIMSIYGIAAVIAK-PTIGFISDRISLPRNYLAAIVMFLFSPALLIFAntTNPDMLYITAPLLGMGAFMYSPLT 333
Cdd:cd17330   208 SPSQIGLLLALVGIAGILAQlLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFA--SSVPLLVLAAAILAFGTGIVFPAL 285
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1011507046 334 NAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMAlSISPIIGAILLSL 398
Cdd:cd17330   286 SALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLA-AGLLLIALFLLSL 349
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
64-395 1.63e-12

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 68.40  E-value: 1.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  64 LPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVL-RFLLGIVSGPVQSACLKAIGeHFSAEQRGTAVGIFMS 142
Cdd:cd17490    49 IPLGILSDRIGKRKLFIIIGLLFTVLASLIMILFPSPWGLLIaRFLSGIAAATWVSFTVLYAS-YFPPDEAAKAMGLINL 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 143 CTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFtVKEVQAFRKNHTVEVQgteprcmslaqSLRFVGTNRN 222
Cdd:cd17490   128 VNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLF-IKEERREKKPVLTELK-----------ELLSVLKDKK 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 223 ILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRiSLPRNYLAAIVMFLFSPA 302
Cdd:cd17490   196 LLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYK-KLGERNTIIIGFLLLGAY 274
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 303 LLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGnYQTAL 382
Cdd:cd17490   275 CFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFG-LQTGF 353
                         330
                  ....*....|...
gi 1011507046 383 MALSISPIIGAIL 395
Cdd:cd17490   354 FVIGVIALLAAIL 366
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
52-191 1.89e-12

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 67.96  E-value: 1.89e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  52 LTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVL--RFLLGIVSGPVQSACLKAIGEHFS 129
Cdd:cd17380    40 LSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLIlsRILLGLGEGVHFPSMTSLFSRWVP 119
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1011507046 130 AEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVQA 191
Cdd:cd17380   120 VSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLPPVWA 181
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
52-191 4.43e-12

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 66.87  E-value: 4.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  52 LTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGL--VLRFLLGIVSGPVQSACLKAIGEHFS 129
Cdd:cd17318    62 LSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGAliVLRILQGLAQGVTFPAMHALWAKWAP 141
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1011507046 130 AEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVQA 191
Cdd:cd17318   142 PLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLVLPVWA 203
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
67-376 1.37e-11

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 65.71  E-value: 1.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  67 GLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSAClKAIGEHFSAEQRGTAVGIFMSCTSF 146
Cdd:PRK09874   75 GGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNAN-ALIATQVPRNKSGWALGTLSTGGVS 153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 147 GITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKE-VQAFRKNHTVEVQgteprcmSLAQSLRfvgTNRNILL 225
Cdd:PRK09874  154 GALLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIREnFQPVSKKEMLHMR-------EVVTSLK---NPKLVLS 223
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 226 LAVMGFFATGTTWGVTTWANLY---LVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISlPRNYLaaIVMFLFSPA 302
Cdd:PRK09874  224 LFVTTLIIQVATGSIAPILTLYvreLAGNVSNIAFISGMIASVPGVAALLSAPRLGKLGDRIG-PEKIL--ITALIFSVL 300
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1011507046 303 LLI-FANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATG 376
Cdd:PRK09874  301 LLIpMSFVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYG 375
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
31-373 1.57e-11

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 65.86  E-value: 1.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  31 SSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLG 110
Cdd:TIGR00711  22 NVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQG 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 111 IVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVQ 190
Cdd:TIGR00711 102 FGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILPRDK 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 191 A---------------------------------FRKNHTV--EVQGTEPRCMSLAQSLRF--------VGTNRNILLLA 227
Cdd:TIGR00711 182 PaasenfdflgllllsvglgsllyglsegpergwFDSNEILilSITGLVAIIAFVVWELTDdnplvdlrLFKYRNFTIGC 261
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 228 VMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFspALLIFA 307
Cdd:TIGR00711 262 VYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIGLILYAV--GFYWRA 339
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 308 NTTNPDMLY--ITAPLLGMG---AFMYSPLTNaIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLT 373
Cdd:TIGR00711 340 FTFTPDTPFlaIALPQFIRGfgmGCFFMPLTT-IALSGLPPHKIARGSSLSNFTRQLGGSIGTALITTILT 409
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
34-396 2.24e-11

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 64.90  E-value: 2.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  34 MPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVS 113
Cdd:cd17320    22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGA 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 114 GPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEvqafr 193
Cdd:cd17320   102 AAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPE----- 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 194 knhTVEVQGTEPRCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIA 273
Cdd:cd17320   177 ---TLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILG 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 274 KPTIGFISDRISLPRN-YLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMG---AFMYSPLTNAIIiqAAPPELRGTT 349
Cdd:cd17320   254 SLLNGRLVRRFGPRRLlRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFfgfGLIFPNATSLAL--EPFPHVAGTA 331
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1011507046 350 AGFVNLFNQ-IGALTAPIILSTVLTATGNYQTALMALSISPIIGAILL 396
Cdd:cd17320   332 SALLGFLQFlIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
2_A_01_02 TIGR00880
Multidrug resistance protein;
51-188 3.43e-11

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 60.74  E-value: 3.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  51 YLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSA 130
Cdd:TIGR00880   3 LLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPP 82
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1011507046 131 EQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKE 188
Cdd:TIGR00880  83 EERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
223-395 7.09e-11

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 62.97  E-value: 7.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 223 ILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISlpRNYLAAIVMFLFSPA 302
Cdd:COG2271    11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFG--RRRVLAIGLLLWGLA 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 303 LLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGnYQTAL 382
Cdd:COG2271    89 TLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-WRAAF 167
                         170
                  ....*....|...
gi 1011507046 383 MALSISPIIGAIL 395
Cdd:COG2271   168 LILGLPGLLLALL 180
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
33-189 1.08e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 62.58  E-value: 1.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  33 LMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFG--YRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLG 110
Cdd:COG2271   203 LPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAG 282
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1011507046 111 IVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEV 189
Cdd:COG2271   283 FGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRET 361
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
39-396 1.43e-10

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 62.27  E-value: 1.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  39 EALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQS 118
Cdd:cd17327    34 EDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFP 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 119 ACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVH------YGWQMAFLITALLPL---LVFFLAL------ 183
Cdd:cd17327   114 GFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKIlgvgglAGWRWLFIIEGLITIiigLVIFFWLpdnpsk 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 184 ---FTVKE----VQAFRKNHTvevqGTEPRCMSLAQSLRFVGTNRNILLlaVMGFFATGTTWGVTTWANLYLVKQLHVTP 256
Cdd:cd17327   194 awfLTEEEkelaVERLRANQT----GKGDQKFKWKQIKEAFKDPRTWLL--FLFFFCSQITNNGISNFLPLILKSLGFYS 267
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 257 IFAGAIMSIYGIAAVIAKPTIGFISDRIslPRNYLAAIVMFLFS-PALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNA 335
Cdd:cd17327   268 LQTNLLSVPIGALGAVSLLIAALLSDRF--KKRGLFAIFACVLAlVGSIILLAAPNPPGAYFAAYILGGGSYAGFPILLS 345
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1011507046 336 -IIIQAAPPELRGTTAGFVNLFNQIGALTAPIILstVLTATGNYQTALMALSISPIIGAILL 396
Cdd:cd17327   346 wISSNCAGYTKRATVLAIMLIFYNVGNIVAPQIF--RAGDAPRYIPGNIALLVCACVSIVLS 405
MFS_UhpC cd17488
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ...
24-396 2.05e-10

Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341041 [Multi-domain]  Cd Length: 364  Bit Score: 61.65  E-value: 2.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  24 FVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGL 103
Cdd:cd17488    16 YLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSSSLWAFA 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 104 VLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLAL 183
Cdd:cd17488    96 VLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYVPGIIAILMGIVLC 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 184 FTVKEvqafrknhtvevqgteprcmslaqslrfvgTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIM 263
Cdd:cd17488   176 WRLRD------------------------------RPPYIWLLAFCYVLVYVVRTAINDWGNLYLSETHGYSLVKANSAV 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 264 SIYGIAAVIAKPTIGFISDRIS----LPRNYLAAIVMfLFSPALLIFANTTNPDMLYITapLLGMGAFMYSP--LTNAII 337
Cdd:cd17488   226 SLFEVGGLIGALVAGWGSDKLFkgnrGPMNLIFALGL-LVSVGALWLVPVHSYWLLATC--FFTIGFFVFGPqmLIGMAA 302
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1011507046 338 IQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGnYQTALMALSISPIIGAILL 396
Cdd:cd17488   303 AECSHKDAAGSATGFVGLFAYLGAALAGYPLAKVIESWG-WSGFFIVISIAAAISGLLL 360
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
30-367 2.19e-10

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 61.82  E-value: 2.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  30 WSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLL 109
Cdd:cd17323    18 YSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQ 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 110 GIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEV 189
Cdd:cd17323    98 GFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLPIV 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 190 QafrknhtvevqgteprCMSLAQSLRFVgtnrnILLLAVMGFfatgttwgvttwaNLYLVKQLHVTPIFAGAIMSIYGIA 269
Cdd:cd17323   178 L----------------LLGLYVGLVYA-----ILYLFLTAF-------------PYVFGEVYGFSPGEVGLMYLPIGIG 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 270 AVIAKPTIGFISDRISLPRN-------------YLAAIVMFLFSPALLIFANTTNPD----MLYITAPLLGMGAFMYSPL 332
Cdd:cd17323   224 ALIGSIIGGRLSDYYYRRLKkknggkpepearlPPAFIGAFLFPIGLFIFGWTIYPHihwiVPIIGSAFFGFGLMLIFQS 303
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1011507046 333 TNAIIIQAAPPELRGTTAGFvNLFNQIGALTAPII 367
Cdd:cd17323   304 SLTYLVDSYPKYAASALAAN-TLVRSIFAAIFPLF 337
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
221-398 2.54e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 61.53  E-value: 2.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 221 RNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFS 300
Cdd:COG2814     9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 301 PALLIFAntTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPiILSTVLTATGNYQT 380
Cdd:COG2814    89 SLLCALA--PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGP-LLGGLLADLFGWRW 165
                         170
                  ....*....|....*...
gi 1011507046 381 ALMALSISPIIGAILLSL 398
Cdd:COG2814   166 VFLVNAVLALLALLLLLR 183
2A0108 TIGR00886
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
23-361 2.95e-10

nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]


Pssm-ID: 273322 [Multi-domain]  Cd Length: 354  Bit Score: 61.16  E-value: 2.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  23 SFVMRLSWSSLMP-IVNEALHFTAQQ-GTSYLTAFYFGyALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTV-QSY 99
Cdd:TIGR00886  13 SFLVWFAFSPLAVfLIKDDLGLSTAQlGNLVAVPVLAG-AVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSY 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 100 EYGLVLRFLLGIVSGPVQSaCLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVA----------VHYGWQMAFL 169
Cdd:TIGR00886  92 SVLLLIRLFIGIAGGSFAS-CMPWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIgslifgggqpAHLAWGWAFV 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 170 I-TALLPLLVFFLALFTVKEvqafrknhTVEVQGTEPRCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWanLYL 248
Cdd:TIGR00886 171 IvPAGILLLPALLIFFVGAD--------TPPGKPATGKLSFKEALKVFGNRHTWILALLYSVTFGSFLGVSSIFA--MLF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 249 VKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFANTTNPDMLyiTAPLLGMGAFM 328
Cdd:TIGR00886 241 KDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFLVVLGLVSDGSLA--AFIVLFVALFF 318
                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1011507046 329 YSPLTNAIIIQAAP---PELRGTTAGFVNLFNQIGA 361
Cdd:TIGR00886 319 FAGAGNGSTFALVPhifRRATGAVSGLIGAIGNLGG 354
MFS_1 pfam07690
Major Facilitator Superfamily;
226-400 7.08e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 60.12  E-value: 7.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 226 LAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLI 305
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 306 FANTTNpdMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPiILSTVLTATGNYQTALMAL 385
Cdd:pfam07690  81 FASSLW--LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGP-LLGGLLASLFGWRAAFLIL 157
                         170
                  ....*....|....*
gi 1011507046 386 SISPIIGAILLSLIR 400
Cdd:pfam07690 158 AILSLLAAVLLLLPR 172
PRK11663 PRK11663
glucose-6-phosphate receptor/MFS transporter UhpC;
53-372 7.18e-10

glucose-6-phosphate receptor/MFS transporter UhpC;


Pssm-ID: 183266 [Multi-domain]  Cd Length: 434  Bit Score: 60.49  E-value: 7.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  53 TAFYFGYALTVLPGGLLADRFGYRKSILGSLVAmaivTGLMSTVQSYEYGLVLRFLLGIVSGPVQS----ACLKAIGEHF 128
Cdd:PRK11663   65 TLFYITYGVSKFVSGIVSDRSNARYFMGIGLIA----TGIINILFGFSSSLWAFALLWVLNAFFQGwgwpVCAKLLTAWY 140
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 129 SAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKE---------VQAFRKNHTVE 199
Cdd:PRK11663  141 SRTERGGWWAIWNTAHNVGGALIPLVVGAIALHYGWRYGMMIAGIIAIVVGLFLCWRLRDkpqamglpsVGEWRHDALEL 220
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 200 VQGTEPRCMSLAQSL-RFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIG 278
Cdd:PRK11663  221 AQQQEGAGLSRKEILtKYVLLNPYIWLLSFSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAG 300
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 279 FISDRI----SLPRNYLAAIVMFLFSPALLIFANTTnpdMLYITAPLLGMGAFMYSP--LTNAIIIQAAPPELRGTTAGF 352
Cdd:PRK11663  301 WGSDKLfngnRGPMNLIFAAGILLSVGSLWLMPFAS---YVMQAACFFTIGFFVFGPqmLIGMAAAECSHKEAAGAATGF 377
                         330       340
                  ....*....|....*....|
gi 1011507046 353 VNLFNQIGALTAPIILSTVL 372
Cdd:PRK11663  378 VGLFAYLGAALSGYPLAKVL 397
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
29-184 7.19e-10

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 59.88  E-value: 7.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  29 SWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGL-VLRF 107
Cdd:cd17477   206 AFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALlVLLF 285
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1011507046 108 LLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVvngyAPFVAvhyGWQMAFLITALLPLLVFFLALF 184
Cdd:cd17477   286 LWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVI----GPLLA---GALMDAFGPHGLFLFLAAVALL 355
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
52-402 9.46e-10

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 59.92  E-value: 9.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  52 LTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYeYGLVL-RFLLGivSGPVQSACLKAIGEHFSA 130
Cdd:cd17472    38 LGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSI-YGLILgRALQG--SGAISSVVMALLADLTRE 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 131 EQRGTA---VGIFMScTSFGITVVNGyaPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVqafrKNHTVEvqgtepRC 207
Cdd:cd17472   115 ENRTKAmalIGASIG-IAFAISMVLG--PLLAAHLGVSGLFLITAILSLVSLLILLFFVPDP----PKIVQI------SE 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 208 MSLAQSLRFVgTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLP 287
Cdd:cd17472   182 KEKKKLKKLL-KNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMK 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 288 RNYLAAIVMFLFSPALLIFANtTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPiI 367
Cdd:cd17472   261 QVFVSSILLIAVGFLLLLFAA-TSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGG-A 338
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1011507046 368 LSTVLTATGNYQTALMALSIspIIGAILLSLIRLK 402
Cdd:cd17472   339 LGGLLWGLLGYSSVFLTILI--LALLWLLVSFLLP 371
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
52-400 1.51e-09

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 59.13  E-value: 1.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  52 LTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIvSGPVQSACLKAIGEHFSAE 131
Cdd:cd17504    37 LTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGI-GGAVFPLAFALVREEFPPE 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 132 QRGTAVGIFMSctSFGITVVNGY--APFVAVHYGWQMAFLITAllPLLVFFLALFTVKEVQAFRknhtvevqgteprcms 209
Cdd:cd17504   116 RVPVAQGILSA--TFGIGAGIGLplGGWIVQHLGWRWIFWTAA--PVAVLLAALVPLIDLRLLR---------------- 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 210 laqslrfvgtNRNILLLAVMGFFATGTTWGVTtwanlYLVKQLHVTP---------IFAGAIMSIYGIAAVIAKPTIGFI 280
Cdd:cd17504   176 ----------RRNVLLANITALLAGFGMFMVF-----QLLPQLLQLPtptgfglgiTEAGLLLLPGALVMLIAGPLAGRL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 281 SDRISLPRNYLAAIVMFLFSpALLIFANTTNPDMLYITAPLLGMG-AFMYSPLTNaIIIQAAPPELRGTTAGFVNLFNQI 359
Cdd:cd17504   241 IARVGPRRVLLIGLVISAVG-LLLLALLHSSLWALVVALLLIGIGlGLAFASLPN-IVVESVPPDRTGIATGMNTVLRTI 318
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1011507046 360 GALTAPIILSTVLTA------------TGNYQTALMALSISPIIGAILLSLIR 400
Cdd:cd17504   319 GSAIGPAIAGAILTTytvsitsggvptEGAYVLAFLIGAALALAALLLSLLIP 371
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
36-184 2.11e-09

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 58.38  E-value: 2.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  36 IVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYE--YGLVLRFLLGIVS 113
Cdd:cd17316   203 YLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSptLLLLLLFILSFFV 282
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 114 GPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALF 184
Cdd:cd17316   283 GGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
67-394 3.84e-09

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 57.92  E-value: 3.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  67 GLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYE-YGL-------VLRFLLGIVSGPVQSACLKAIGEHFSAEQR----- 133
Cdd:cd17369    65 GHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYAqIGIlapillvLLRLLQGLALGGEWGGAVLMAVEHAPPKRRgfygs 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 134 ----GTAVGIFMSCTSF-GITVVNGYAPFVAvhYGWQMAFLITALLpLLVFFLALFTVKEVQAFRKnhtVEVQGTEPRcM 208
Cdd:cd17369   145 fpqlGAPVGLLLATGVFlLLSALLSDEAFLS--WGWRIPFLLSAVL-VAVGLYIRLRLEETPVFRR---AKEAGQVVR-A 217
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 209 SLAQSLRfvgTNRNILLLAVMGFFATGTTWGVTTWANL-YLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLP 287
Cdd:cd17369   218 PLVEVLR---RHWRALLLAIGLRLAENVLFYLFTTFALsYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRR 294
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 288 RNYLA-AIVMFLFSPALLIFANTTNPdMLYITAPLLGMGAF---MYSPLtNAIIIQAAPPELRGTTAGFV-NLFNQIGAL 362
Cdd:cd17369   295 PVYLAgALLAALFAFPFFWLLDTGST-WLIVLAAVVVLGVLhgmMYGPQ-AAFLAELFPTRVRYTGASLGyQLGAILGGG 372
                         330       340       350
                  ....*....|....*....|....*....|..
gi 1011507046 363 TAPIILSTVLTATGNYQTALMALSISPIIGAI 394
Cdd:cd17369   373 FAPLIATALVAATGSWWPVALYLAALAVISLV 404
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
66-394 9.65e-09

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 56.89  E-value: 9.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  66 GGLLADRFGyRKSILGSLVA----MAIVTGLmstVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFM 141
Cdd:PRK11551   70 GGRLADRIG-RKRILIVSVAlfglFSLATAQ---AWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMY 145
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 142 SCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVQAFRKNHTVEVQGTeprcmSLAQSLRFVGTNR 221
Cdd:PRK11551  146 CGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAFAQAAGAGKQRA-----PVLRALFGEGRAT 220
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 222 NILLLAVMGFFATGTTWGVTTWANLYLVKQlHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSP 301
Cdd:PRK11551  221 ATLLLWISYFFTLIVLYFLLNWLPSLLVGQ-GLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVLLIYAGILASL 299
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 302 ALLIFANTTNPdmLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTA 381
Cdd:PRK11551  300 AALAAAPSFAG--MLLAGFAAGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLLALGRSTVGV 377
                         330
                  ....*....|...
gi 1011507046 382 LMALSISPIIGAI 394
Cdd:PRK11551  378 IGASIPVILVAAL 390
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
7-150 2.65e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 54.98  E-value: 2.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046   7 LTQTGILLTLWLTFLLSFVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAM 86
Cdd:COG2814   204 LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL 283
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1011507046  87 AIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITV 150
Cdd:COG2814   284 ALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
29-399 3.14e-08

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 54.92  E-value: 3.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  29 SWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSIL--GSLVAMAIVTGLMSTVQSYEYgLVLR 106
Cdd:cd17353    21 AWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILigGILFGLGFILSAFAISLPLLF-LGYG 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 107 FLLGIVSGPVQSACLKAIGEHFSaEQRGTAVGIfmscTSFGItvvnGYAPFVAV--------HYGWQMAFLITALLPLLV 178
Cdd:cd17353   100 VLGGIGAGIGYITPVSTAVKWFP-DKRGLATGI----VIAGF----GLGSLIFSpliaylinTVGVPTTFLILGIIFLII 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 179 FFLALFTVKE----VQAFRKNHTVEVQGTEPRCMSLAQSLRfvgtNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHV 254
Cdd:cd17353   171 IVIGAFLIRDppkgWVPPGVDPLANNAENSPRDYTPREMLR----TPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGL 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 255 TPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFANTTNP-DMLYITAPLLGMGAFMysPLT 333
Cdd:cd17353   247 DAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVlFVLGVALIGFCYGGGF--ALF 324
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1011507046 334 NAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIIlSTVLTATGNYQTALMALSISPIIGAILLSLI 399
Cdd:cd17353   325 PALTADFFGTKNAGTNYGLLYTAKGVGGLIGPII-AAYVLYTGGYNAAFIIAAALSLVALALALLL 389
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
39-183 3.90e-08

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 54.86  E-value: 3.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  39 EALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQS 118
Cdd:cd17370   227 QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQES 306
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1011507046 119 ACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLAL 183
Cdd:cd17370   307 IERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
129-337 4.97e-08

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 54.53  E-value: 4.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 129 SAEQRGTAVGIFMSCTSFGITVVNGYAPFV-------AVHYGWQMAFLITALLPLLVFFLALFTVKEVQAFRKNHTVEVq 201
Cdd:cd17332   130 DPEERTSLTSWRMFFATIGGLLVTVLPPPLvayfgggNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKL- 208
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 202 gteprcmSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAgAIMSIYGIAAVIAKPTIGFIS 281
Cdd:cd17332   209 -------PLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELV-LLLLLILSGALLALLPWPPLK 280
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1011507046 282 DRISLPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAII 337
Cdd:cd17332   281 KRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAML 336
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
29-191 9.26e-08

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 53.70  E-value: 9.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  29 SWSSLmpIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFL 108
Cdd:COG0738   231 DWLPL--YLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLAL 308
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 109 LGIVSGPVQSACLKAIGEHFSaEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKE 188
Cdd:COG0738   309 VGLGLSLMFPTIFSLALDGLG-KRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRK 387

                  ...
gi 1011507046 189 VQA 191
Cdd:COG0738   388 RRK 390
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
57-396 9.52e-08

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 53.70  E-value: 9.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  57 FGYALTVLpGGLLADRFGYRKS--ILGSLVAMAIVtGLMSTVQSYEYGLVLRFLLGIVSGpVQSACLKAIGEHFSAEQ-R 133
Cdd:cd17370    46 LGSLLRLF-SGYLSDRTGKRKPlvILGYGLSALAK-PLLALAGSWQLVLLLRILERLGKG-IRTPPRDALLADATPPSgR 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 134 GTAVGIFMSCTSFGITVvngyAPFVAV------HYGWQMAFLItALLPLLVFFLALFTVKEvqAFRKNHTVEVQGTEPRC 207
Cdd:cd17370   123 GKAFGLHRALDTLGAVL----GPLLAAlllyllGGNYRTIFLL-AAIPALLALLILLFVVK--EYPRPPKLRKKSKKTSL 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 208 MSLAQSLRFVGTnrnILLLAVMGFFATGTTwgvttwanLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLP 287
Cdd:cd17370   196 KKLPKAFWLYLL---AVALFALGNFSFAFL--------ILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRK 264
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 288 RNYLAAIVMFLFSPalLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPII 367
Cdd:cd17370   265 KLLILGYLSLALAY--LGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLI 342
                         330       340
                  ....*....|....*....|....*....
gi 1011507046 368 LStVLTATGNYQTALMALSISPIIGAILL 396
Cdd:cd17370   343 AG-YLWDLISPSAAFLFSAVLALIALLLL 370
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
221-376 1.31e-07

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 52.89  E-value: 1.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 221 RNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFS 300
Cdd:COG0477    13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1011507046 301 PALLIFAntTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATG 376
Cdd:COG0477    93 SLLCGLA--PSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG 166
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
54-185 2.72e-07

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 52.19  E-value: 2.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  54 AFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQR 133
Cdd:cd17315    42 SLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIR 121
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1011507046 134 GTAVGIFMSCTSFGITVVN--GYAPFVAVHYGWQMAFLITALLPLLVFFLALFT 185
Cdd:cd17315   122 GALGTLNQLMITFGILLAYllGLALSLSPPGWWRLMFALAAVPALLQLLLMFFL 175
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
67-310 3.91e-07

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 51.78  E-value: 3.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  67 GLLADRFGYRKS-ILGSLVAMAIVTGLMSTVQSYeyglVLRFLLGIVSGPVQSAC---LKAIGEHFSAEQRGTAVGIFMS 142
Cdd:cd17471    53 GRLSDRGGDRKPlILLALLAGALGYLLFAFLRNY----WVLLLVGVVLLSLGAAAfpqLFALAREYADRSSGRDATLFNS 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 143 ----CTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVQAFRKNHTVevqgteprcmslAQSLRFVG 218
Cdd:cd17471   129 vlraAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATP------------ASSLVKAP 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 219 TNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMsiyGIAAVIAKPTI---GFISDRISLPRNYLAAIV 295
Cdd:cd17471   197 VNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLF---GLAAALEIPIMllaGLLAKRFGKRRLLLAGFL 273
                         250
                  ....*....|....*
gi 1011507046 296 MFLFSPALLIFANTT 310
Cdd:cd17471   274 AGVLFYLGLALATSL 288
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
45-184 4.14e-07

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 51.45  E-value: 4.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  45 AQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAI 124
Cdd:cd17490   230 FQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLS 309
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 125 GEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALF 184
Cdd:cd17490   310 IEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLA 369
PLN00028 PLN00028
nitrate transmembrane transporter; Provisional
23-285 4.44e-07

nitrate transmembrane transporter; Provisional


Pssm-ID: 177665 [Multi-domain]  Cd Length: 476  Bit Score: 51.85  E-value: 4.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  23 SFVMRLSWSSLMPIVNEALHFTAQQ-GTSYLTAFYfGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEY 101
Cdd:PLN00028   48 CFVSTFAAAPLLPIIRDNLNLTKSDiGNAGIASVS-GSIFSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATG 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 102 GLVLRFLLGIvSGPVQSACLKAIGEHFSAEQRGTAVGI-------------FMSCTSFGITVVNGYAPFVAvhygWQMAF 168
Cdd:PLN00028  127 FIAVRFFIGF-SLATFVSCQYWMSTMFNGKIVGTANGIaagwgnlgggvtqLLMPLVFPLIKDAGAPSFTA----WRIAF 201
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 169 LITALLPLLVFFLALFTVKEVQ--AFRknhTVEVQGTEPRcMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANL 246
Cdd:PLN00028  202 FVPGLLHIIMGILVLTLGQDLPdgNYR---ELKKSGTMPK-DSFSKVLRYGVTNYRTWILALTYGYSFGVELTMDNIIAE 277
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1011507046 247 YLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRIS 285
Cdd:PLN00028  278 YFYDRFGLSLETAGAIAASFGLMNLFARPAGGYLSDVAA 316
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
53-187 5.16e-07

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 51.04  E-value: 5.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  53 TAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQ 132
Cdd:cd17317    32 TIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKY 111
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1011507046 133 RGTAVGIFMSCTSFGITVVNGYAPFVAvhyGWQMAFLITALLPLLVFFLALFTVK 187
Cdd:cd17317   112 RSFVGILFGLFWALGYMLLALLAYLIR---DWRWLQLAISLPGLLFLLLLWWLPR 163
MFS_SLC18A3_VAChT cd17383
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ...
67-203 6.52e-07

Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340941 [Multi-domain]  Cd Length: 378  Bit Score: 50.77  E-value: 6.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  67 GLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAE-QRGTAVGIFMSCTS 145
Cdd:cd17383    51 GTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFFARSLQGVGSAFADTAGLAMIADRFTEEaERSKALGIALAFIS 130
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 146 FGITVVngyAPFVAVHY---GWQMAFLITALLPLLVFFLALFTVKEVQAFRKNHTVEVQGT 203
Cdd:cd17383   131 FGCLVA---PPFGGILYefaGKEVPFLILAFVCLLDGLLLLLVMKPVRRETRANMPEPVGT 188
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
27-398 6.64e-07

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 50.87  E-value: 6.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  27 RLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRK-SILGSLVAMAIVTGLMSTVQSYEYGLVL 105
Cdd:cd17314    19 ILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPlMALAGIMVLAGYTYLSYVFNSFPLSYAC 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 106 RFLLGIVSGPVQSACLKAIGEHFSaEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALlpllvffLALFT 185
Cdd:cd17314    99 FVFIGAGTGILYGSAVLVTTQYFP-DTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGI-------LAAIV 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 186 VKEVQAFRKNHTVEVQGTEPRCMSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSI 265
Cdd:cd17314   171 LSVVSLLGFKEPPDNQARLHVQKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLDAPSFVTKLMSI 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 266 YGIAAVIAKPTIGFISDRIsLPRNYLAAIVMFLFSPAL--LIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPP 343
Cdd:cd17314   251 YGLFNAFGRLLWGIVADFF-GGRLSTLSILLTILGLGLcaFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGT 329
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1011507046 344 ELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILLSL 398
Cdd:cd17314   330 ESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILLA 384
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
53-188 1.06e-06

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 50.40  E-value: 1.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  53 TAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQ 132
Cdd:TIGR00898 134 SCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQ 213
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1011507046 133 RGTAVGIFMSCTSFGITVVNGYAPFVAvhyGWQMAFLITAlLPLLVFFLALFTVKE 188
Cdd:TIGR00898 214 RAIVGTLIQVFFSLGLVLLPLVAYFIP---DWRWLQLAVS-LPTFLFFLLSWFVPE 265
MFS_4 pfam06779
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ...
27-396 1.51e-06

Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.


Pssm-ID: 399632 [Multi-domain]  Cd Length: 365  Bit Score: 49.68  E-value: 1.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  27 RLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVL--PGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLV 104
Cdd:pfam06779   9 RFSYTPILPVMIAEGQFSLSQAGLLAAANYAGYLAGALlaSFAWRHGASRLRPALLAGLLATVLLLLAMAATSSFWAVLL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 105 LRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALF 184
Cdd:pfam06779  89 IRFLAGVASAAVMIFGSSLILGHATAARRAFVGALLFAGVGIGIALSGLLVPLGLQLGLGGSSLWYGAGVLSAVLTLAVF 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 185 TVKEVQAFRK-NHTVEVQGTEPRCMSLAQslrfvgtnrnilLLAVMGFFATGTTWGVTTWANlyLVKQLHVTPIFAGAIM 263
Cdd:pfam06779 169 PLLPRRAPRHaSAPAPAAKPLQRSLPLWI------------LTLAYGLAGFGYIITATFLPA--MARDGFGGPAAAALFW 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 264 SIYGIAAVIAKptigFISDRISLPRNYLAAIVMFLFSPALLIFANT--TNPDMLYITAPLLGMGAFMYSPLTNAIIIQAA 341
Cdd:pfam06779 235 SLFGLAAALGV----LVWLRAAKRWGTRPALTAALLIQALGVLLSLlsPSPAGLAVSSLLFGGTFMAITSLVMQLARELA 310
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1011507046 342 PPELRgTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILL 396
Cdd:pfam06779 311 PPAPR-RLLGLMTASFGIGQILGPLLASLLTAATGGLTPALLLAAAALVLAALIV 364
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
48-361 4.51e-06

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 48.33  E-value: 4.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  48 GTSYLTAFyfgyALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEH 127
Cdd:cd17502    36 GTAYLLTS----TAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADL 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 128 FSAEQRGTAVGIFMSctSFGITVVNGyaPFV----AVHYGWQMAFLITalLPLLVFFLALFtvkevqafrknhtvevqgt 203
Cdd:cd17502   112 VPPRERGKYQGYIGA--VFGIASVAG--PLIggafTDHLSWRWCFYIN--LPIGGLALALL------------------- 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 204 eprcmslaqslrfvgtnRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDR 283
Cdd:cd17502   167 -----------------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISK 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 284 ISLPRN-YLAAIVMFLFSPALLIFANTTNPDMLYITAP-LLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGA 361
Cdd:cd17502   230 TGRYKPlIVIGTILMSVGAGLLTTLTLDTSKWLLIGYLiLLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGG 309
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
48-402 7.29e-06

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 47.84  E-value: 7.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  48 GTSYLTAFYFGYALTVlpGGLL-----------ADRFGYRKSILGSLVAMAIV-TGLMSTVQ--SYEYGLVLrFLLGIV- 112
Cdd:COG2270    45 GDPAAATALWGYALAI--AGLLvallapvlgaiADRSGRKKPFLAFFTLLGVLaTAALFFVApgGLWLGLLL-FVLANIg 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 113 ---SGPVQSACLKAIGEH-----FSAeqRGTAVGIFMSCTSFGITVV----NGYAPFVAVHYGWQMAFLITALLPLLVFF 180
Cdd:COG2270   122 fegSLVFYNAFLPDIATPeeigrVSG--LGWALGYLGGVLLLLINLAlflkPEAFGLPDAGEAVRISFLLTALWWLLFAL 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 181 LALFTVKEVQAFRKNHTVEVQGTEPRcmSLAQSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTP---I 257
Cdd:COG2270   200 PLFLFLPERPRPGPAPPRGAVRAGFR--ELRRTLRELRRYRDLLRFLLAYFFYRDGVQTVIAFAGIYAAGVLGFSTtelI 277
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 258 FAGAIMSIYGIAAVIAkptIGFISDRISLPRNYLAAIVMFLFSPALLIFANTTNpdMLYITAPLLG--MGAfMYSpLTNA 335
Cdd:COG2270   278 VFGLLVQIVAALGALL---FGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTAL--AFWILGLLIGlvMGG-IQA-LSRS 350
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1011507046 336 IIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILLSLIRLK 402
Cdd:COG2270   351 LLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGSQRLGILSLIVFFVIGLVLLLRVKVP 417
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
67-369 8.71e-06

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 47.63  E-value: 8.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  67 GLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIV--SGPVQSACLKAIGehfSAEQRGTAVGIFMSCt 144
Cdd:cd17388    59 GALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITgaTGAVAAAYIADVT---PPEQRARNFGLLGAA- 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 145 sFGITVVNGYA-PFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVQAFRKNhtvevQGTEPRCMSLAQSLRFVGTNRNI 223
Cdd:cd17388   135 -FGLGFIAGPAlGGLLGEISPRAPFLVAAGLNGLNFLLGLFVLPESLPPERR-----RAFRWRRANPFGSLRWLTGFPGL 208
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 224 LLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKP-TIGFISDRISLPRNYLAAivMFLFSPA 302
Cdd:cd17388   209 LGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAfVTGPIAKRLGEKRAILLG--LAADALG 286
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 303 LLIFANTTNPDMLYITAPLLGMGAfMYSPLTNAIIIQAAPP----ELRGTTAGFVNLFNQIGALTAPIILS 369
Cdd:cd17388   287 FLLLAFATQGWMVFPILILLALGG-IAGPALQGLLSRQVPEneqgELQGVLTSLTSLTSIIGPLLFTGIFA 356
PRK12307 PRK12307
MFS transporter;
33-367 1.17e-05

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 47.23  E-value: 1.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  33 LMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGI- 111
Cdd:PRK12307   40 IMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMg 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 112 VSGPVQSACLKAIgEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLItALLPLLVFFLALFTVKEVQA 191
Cdd:PRK12307  120 MAGEYACASTYAV-ESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFV-GLLPVLLVIYIRARAPESKE 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 192 FRKNhTVEVQGTEPRCMSLAQSLRFVGT-NRNILLLAVMGFFATGTTWGVTTWANLYLVKQLH---VTPIFAGAIMSIYG 267
Cdd:PRK12307  198 WEEA-KLSGKGKHSQSAWSVFSLSMKGLfNRAQFPLTLCVFIVLFSIFGANWPIFGLLPTYLAgegFDTGVVSNLMTAAA 276
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 268 IAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFANTTNpdMLYITAPLLGMGA--FMYSPLTNAIIIQAAPPEL 345
Cdd:PRK12307  277 FGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFPLFRIPQDN--YLLLGACLFGLMAtnVGVGGLVPKFLYDYFPLEV 354
                         330       340
                  ....*....|....*....|..
gi 1011507046 346 RGTTAGFVNLFNQIGALTAPII 367
Cdd:PRK12307  355 RGLGTGLIYNLAATSGTFNSMA 376
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
247-402 1.29e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 46.78  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 247 YLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRIslPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGA 326
Cdd:cd17478    21 LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRK--PRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGS 98
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1011507046 327 FMYSPLTNAIIIQAAPPElRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILLSLIRLK 402
Cdd:cd17478    99 AAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
227-399 1.54e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 46.65  E-value: 1.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 227 AVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIF 306
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 307 AntTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILS-TVLTATGNYQTALMAL 385
Cdd:cd06174    81 A--PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGiLASSLGFGWRAVFLIA 158
                         170
                  ....*....|....
gi 1011507046 386 SISPIIGAILLSLI 399
Cdd:cd06174   159 AALALLAAILLLLV 172
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
57-177 2.12e-05

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 46.19  E-value: 2.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  57 FGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTa 136
Cdd:cd17379    44 LGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRT- 122
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1011507046 137 VGIFMSCT-SFGITVVNGYAPFVAVHYGWQMAFLITALLPLL 177
Cdd:cd17379   123 VGIVYQMFfTLGLLILPGIAYFIPHWRWLQLAVTLPNFLFLL 164
Sugar_tr pfam00083
Sugar (and other) transporter;
260-402 2.15e-05

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 46.50  E-value: 2.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 260 GAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFAN-TTNPDMLYITAPLLGMGAFMYSPLTNAIII 338
Cdd:pfam00083  49 GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgKWSVYQLIVGRVLVGIGVGGASVLAPMYIS 128
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1011507046 339 QAAPPELRGTTAGFVNLFNQIGALTAPIIlsTVLTATGNYQTALMALSISPIIGAILLSLIRLK 402
Cdd:pfam00083 129 EIAPKKLRGALGSLYQLAITFGILLAYIF--GLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLF 190
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
43-186 3.25e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 45.66  E-value: 3.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  43 FTAQQGTSYLTAFYFGYALTVLP----GGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQS 118
Cdd:cd17489   220 YAAERGISNAGLFFTVYAIALLLsrpfSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFP 299
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1011507046 119 ACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTV 186
Cdd:cd17489   300 ALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
1-147 3.44e-05

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 45.81  E-value: 3.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046   1 MKKGFTLTQTGILLTLWLTFLLSFVMRLSWsslMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSIL 80
Cdd:TIGR00895 243 LFQGKTARITVLLWLLYFMLLVGVYFLTNW---LPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTAL 319
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1011507046  81 GSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFG 147
Cdd:TIGR00895 320 LLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLG 386
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
53-189 3.94e-05

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 45.43  E-value: 3.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  53 TAFYFGYALTVLPGGLLAD-RFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAE 131
Cdd:cd17378    40 SSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEPVGPK 119
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1011507046 132 QRGTAVGIFMSCTSFGITVVNGYAPFvaVHYGWQMAFLITALLPLLVFFLALFTVKEV 189
Cdd:cd17378   120 WRGQVGMSTFFFFVLGFMSLPGIAYL--NGSSWRVLYFWTSIPALIYCILVYLFARRL 175
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
67-186 4.50e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 45.33  E-value: 4.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  67 GLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSF 146
Cdd:cd17391   261 GKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYL 340
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1011507046 147 GITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTV 186
Cdd:cd17391   341 GNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
31-183 5.22e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 44.85  E-value: 5.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  31 SSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLrFLLG 110
Cdd:cd17478   215 TTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAG 293
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1011507046 111 IVSGPVQSACLkAIGEHFSAEQRGTAVGIFMScTSFGI----TVVNGYapfVAVHYGWQMAFLITALLPLLVFFLAL 183
Cdd:cd17478   294 FLLFASFPVTV-VLAQELLPGNVGLASGLMMG-LSFGLggigAPVLGA---LADAFGLESVLLILALLPLLGALLAF 365
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
35-184 8.72e-05

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 44.13  E-value: 8.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  35 PIVNEALHFTAQQgTSYLTAfYFGYALTVLPG---GLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGI 111
Cdd:cd17331   232 LVAMDFFGLTPEE-NGYLMS-YAGVLGMVVQGllvGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVI 309
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1011507046 112 VSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALF 184
Cdd:cd17331   310 GGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
23-188 9.18e-05

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 44.49  E-value: 9.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  23 SFVMRLSWSS-----LMPIVNEALHFTAQQG---TSYLTafyFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMS 94
Cdd:cd17358    13 SFGIAVGWSSpalpsLMSDNSLSLPLTVAQFswfGSLLT---LGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIA 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  95 TVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAvhygWQMAFLItALL 174
Cdd:cd17358    90 FAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLP----WRTLALI-GAI 164
                         170
                  ....*....|....
gi 1011507046 175 PLLVFFLALFTVKE 188
Cdd:cd17358   165 PPVVFLILLFFIPE 178
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
67-386 9.77e-05

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 44.21  E-value: 9.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  67 GLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYE--------YGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVG 138
Cdd:cd17367    61 GRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYAtigiwapiILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSS 140
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 139 IFMSCTSFGITVVNGYApFVAVH---------YGWQMAFLITALLPLLVFFLALfTVKEVQAFRKnhtvEVQGTEPRCMS 209
Cdd:cd17367   141 FQYVTLIGGQLLALGVL-LVLQHtlgedqmaaWGWRIPFLLGGVLAVVVLWLRR-GLEETESFEA----IAESNEASAGT 214
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 210 LAQSLRFVGTnrnilLLAVMGFFATGTTWGVTTWANL--YLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRIS-- 285
Cdd:cd17367   215 LRELRRHPRE-----LLLVVGLTAGGTLAFYTWTTYLqkFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGrr 289
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 286 ---LPRNYLAAIVMFlfsPALLIFANTTNPDML--YITAPLLGMGAfmYSPLTNAIIIQAAPPELRGTTAGF-VNLFNQI 359
Cdd:cd17367   290 pllLFFGIGGTLATV---PLLSALDHTDSPYTAfaLVLVGLVFLSG--YTSINAVVKAELFPTHVRALGVGLpYALAVAI 364
                         330       340       350
                  ....*....|....*....|....*....|...
gi 1011507046 360 GALTAPIILsTVLTATGN------YQTALMALS 386
Cdd:cd17367   365 FGGTAPYVA-LWLKSIGHewvffwYVAGLIAIS 396
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
31-184 1.30e-04

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 43.68  E-value: 1.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  31 SSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLG 110
Cdd:cd17372    19 SFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVG 98
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1011507046 111 I-VSGPVQSACLKAigEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMaFLITALLPLLVFFLALF 184
Cdd:cd17372    99 LgLGGGPQLASWYL--EFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRW-LLAFSSVPSSLLLVFYR 170
Sugar_tr pfam00083
Sugar (and other) transporter;
54-184 1.47e-04

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 43.80  E-value: 1.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  54 AFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMST---VQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSA 130
Cdd:pfam00083  54 IFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAakgKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPK 133
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1011507046 131 EQRGTAVGIFMSCTSFGITVvnGYAPFVAVHY-----GWQMAFLITALLPLLVFFLALF 184
Cdd:pfam00083 134 KLRGALGSLYQLAITFGILL--AYIFGLGLNKtsnsdGWRIPLGLQLVPALLLIIGLLF 190
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
52-188 1.55e-04

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 43.87  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  52 LTAFYFGYALTVLPGGLLADRFGYRKSILGS---LVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHF 128
Cdd:TIGR00879  77 VSIFLVGGFIGALFAGWLSDRFGRKKSLLIIallFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIA 156
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1011507046 129 SAEQRGTAVGIFMSCTSFGITV---VNGYAPFVAVHYGWQMAFLITALLPLLvFFLALFTVKE 188
Cdd:TIGR00879 157 PKALRGALTSLYQLAITFGILVaygFGSGKVSLNNTLGWRIPLGLQLIPAGL-LFLGLFFLPE 218
MFS_SLC37A3 cd17342
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ...
53-361 1.67e-04

Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340900 [Multi-domain]  Cd Length: 399  Bit Score: 43.46  E-value: 1.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  53 TAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYE--YGLVLRFLLGIVSGPVQSA---CLKAI-GE 126
Cdd:cd17342    70 TIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLhfYNKYLYCILWVLNGLLQSTgwpCVVAImGN 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 127 HFSAEQRGTAVGIFMSCTSFGitvvNGYAPFVA---VHYGWQMAFLITALLPL---LVFFLALFTvkevqafrknhtvev 200
Cdd:cd17342   150 WFGKSSRGFVLGLWSACASVG----NIIGALLAssvLDYGYEYAFLVTSSLLFagaIVVFFGLLS--------------- 210
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 201 QGTEPRCMSLAQSLrfvgtnrniLLLAVMGFFATGTtwgvttwanLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFI 280
Cdd:cd17342   211 SPPGVIPYSLAYAC---------LKLVNYSFFFWLP---------FYLSNNFHWKESEADQLSIWYDVGGIIGGIVAGYI 272
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 281 SDRISlPRNYLAAIVMFLFSPALLIFANTtnPDMLYITAPLLGMGAFMYSPLTNAI--IIQA---APPELRG------TT 349
Cdd:cd17342   273 SDRMG-SRSPVVVVMLLLAIPSLFVYSHS--PSDKVLNAFVMTITGFFIGGPANLIssAISAdlgRQPQLRGssealaTV 349
                         330
                  ....*....|..
gi 1011507046 350 AGFVNLFNQIGA 361
Cdd:cd17342   350 TGIIDGTGSIGA 361
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
46-398 1.69e-04

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 43.43  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  46 QQGTSYLTAFYFGYALTV--LPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKA 123
Cdd:cd17374    33 SQSLKSVAQSIFMAGLLVgaLIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLIL 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 124 IGEHFSAEQRGTAVGIFMSCTSFGITVVNGYApFVAVHygWQMAFLITALLPLLVFFLALFTVKEVQAFrknhtvevqgt 203
Cdd:cd17374   113 GTEWTTPRHRALAITLTSCFFSIGQMLLAGLA-YAIRD--WRLLQLVVSVPFFLFFLYSWWLPKRTLIL----------- 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 204 epRCMSLAQSLRFVGTNRNILLLAVmgffatgttwgvttwaNLYLvkqlhvTPIFAGAIMSiygIAAVIAKPTIGFISDR 283
Cdd:cd17374   179 --SFVWFANSFSYYGLSLDLQHLGL----------------NVFL------LQFLFGAVEV---PARCLALFLLNHMGRR 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 284 ISLprnylaaiVMFLFSPALLIFANTTNP-DMLYITAPLLGMGAFMYSPLTNAIIIQAA---PPELRGTTAGFVNLFNQI 359
Cdd:cd17374   232 ISQ--------AVLLLLAGLCILANIFVPqEMQTLRTVLAVLGKGSSAAAFTISYVYTAelfPTVLRQTGMGLNSMFARI 303
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1011507046 360 GALTAPIILStvltaTGNYQTALMALS--ISPIIGAILLSL 398
Cdd:cd17374   304 GGILAPLIML-----LGVYSPLLPMIIygVLPILAGLLALL 339
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
36-376 1.90e-04

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 43.36  E-value: 1.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  36 IVNEALHFTAQQGT-SYLT------AFYFGYALTV-----LPGGLL----ADRFGYRKSILGSLVAMAIVTGLMSTVQSY 99
Cdd:cd17331     9 IVLYATCYWLQQPVlPYLTkklgvdSVVFGYLQTTfsvlqLVGGPLfgrfGDLFGPRAALVLSFLSSALSYLLLAFASSV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 100 eYGLVLRFLLGIVSGPVQSACLkAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVF 179
Cdd:cd17331    89 -PMLFLSRLPSVFMHAMQAAQM-VVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSI 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 180 FLALFTVKEVQAFRKNHTVEVQGTEPRCMSLAQSLRFVGTnRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFA 259
Cdd:cd17331   167 VLVILLIPSNTKSKREKEAKESASPPSVFNLKEILRLLRL-PGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEEN 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 260 GAIMSIYGIAAVIAKP-TIGFISDRISLPRNYLAAIVMFLFSPALLIFAnTTNPDMLYITAPLLgMGAFMYSPLTNAIII 338
Cdd:cd17331   246 GYLMSYAGVLGMVVQGlLVGPLTKRFGERSLLKLSVALLAIGYLLLAFV-TTVWQLLVLLLPLV-IGGSVLYTVITSLLT 323
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1011507046 339 QAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATG 376
Cdd:cd17331   324 KAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYG 361
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
244-402 2.52e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 42.99  E-value: 2.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 244 ANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISlPRNYL----AAIVMFLFSPALLIFANTTNPDMLYITA 319
Cdd:cd06173    21 ALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFD-RRRLLiladLLRALLAAVLALLALLGSLSLWLLLVLA 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 320 PLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIiLSTVLTATGNYQTALMALSISPIIGAILLSLI 399
Cdd:cd06173   100 FLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPA-LGGLLVALLGPGGAFAINALSFLLSALLLLFI 178

                  ...
gi 1011507046 400 RLK 402
Cdd:cd06173   179 RRP 181
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
248-367 2.55e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 42.95  E-value: 2.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 248 LVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFANTTNpdMLYITAPLLGMGAF 327
Cdd:cd17503    22 IMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLA--SLIIFRILQGFGGG 99
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1011507046 328 MYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPII 367
Cdd:cd17503   100 VLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTL 139
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
250-401 2.72e-04

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 42.99  E-value: 2.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 250 KQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISlpRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMY 329
Cdd:cd17328    27 SDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYN--RKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASY 104
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1011507046 330 SPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMalsISPIIGAILLSLIRL 401
Cdd:cd17328   105 SPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFR---VTGVLGVLLAILLLL 173
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
219-401 2.78e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.92  E-value: 2.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 219 TNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRnyLAAIVMFL 298
Cdd:COG0738     5 NYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKR--GLLLGLLL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 299 FSPALLIFANTTNPDMLYITAPLLGMGAFMYSPLTNAIIIqAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGN- 377
Cdd:COG0738    83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVA-ALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSl 161
                         170       180
                  ....*....|....*....|....*
gi 1011507046 378 -YQTALMALSISPIIGAILLSLIRL 401
Cdd:COG0738   162 sWHLPYLILAVLLLLLALLFLRSKL 186
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
35-183 3.13e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 42.41  E-value: 3.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  35 PIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSIL-GSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVS 113
Cdd:cd06174   228 LFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLlIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGL 307
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 114 GPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAV-HYGWQMAFLITALLPLLVFFLAL 183
Cdd:cd06174   308 GGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAILLL 378
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
56-192 3.35e-04

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 43.04  E-value: 3.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  56 YFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGT 135
Cdd:TIGR01299 212 YLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGE 291
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1011507046 136 AVGIFMSCTSFGITVVNGYAPFVAVHYGW--QMA----------FLITALLPLLVFFLALFTVKEVQAF 192
Cdd:TIGR01299 292 HLSWLCMFWMIGGIYAAAMAWAIIPHYGWsfQMGsayqfhswrvFVIVCAFPCVFAIGALTFMPESPRF 360
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
65-372 3.46e-04

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 42.99  E-value: 3.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046   65 PGGLLADRFGYRKSILGSLVAMAIVTGLM--STVQSYEYGL-VLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTAVGIFM 141
Cdd:PRK08633    66 PAGFLADKFSKNRVIRIVKLFEVGLTLLIvlAYYLGWFWLAfAVTFLLGAQSAIYSPAKYGIIPELVGKENLSRANGLLE 145
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  142 SCTSFGITVVNGYAPFVA-VHYGWQMAFLITALLPLLVFFLALFTVKEVQAFRKNHTVEVQGTEP------RCMSLAQSL 214
Cdd:PRK08633   146 AFTIVAILAGTALFSFLFeSVNGNTPSEILGRIAPAGLVLLAVAVLGLIFAYRLPKVPAAAPEVFdkkkylFPKLLWRNL 225
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  215 RFVGTNRNILLlAVMGFfATGTTWGVTTWANL--YLVKQLHVTPIF-AGAIMSIYGIAAVIAKPTIGFIS-DRISLPRNY 290
Cdd:PRK08633   226 KLLRSDRVLWL-AIIGL-SYFWFISQLAQANFpaYAKEVLGLDNTFqVQYLLAASAIGIGIGSLLAGRLSgRHIELGLVP 303
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  291 LAAIVMFLFspaLLIFANTTNPDMLYITAPLLGMGAFMYS-PLtNAIIIQAAPPELRGTTAGFVNLFNQIGALTApIILS 369
Cdd:PRK08633   304 LGALGLALS---LFLLPTAPSLASVLVLFFLFGFSAGLFIvPL-NALIQFRAPEKELGKVLAANNFLQNVGMLLF-LALT 378

                   ...
gi 1011507046  370 TVL 372
Cdd:PRK08633   379 TLF 381
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
32-383 3.89e-04

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 42.25  E-value: 3.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  32 SLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGI 111
Cdd:cd17476    19 VILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGL 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 112 VSGPVQSACLKAIGEHFS-AEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTvkevq 190
Cdd:cd17476    99 GPAFLLPNAMALLGRTYPpGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAAIFW----- 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 191 afrknhtvevqgteprcmslaqslrfvgTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAA 270
Cdd:cd17476   174 ----------------------------TSPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGG 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 271 VIAKPTIGFISDRIslPRNYLAAIVMFLFSPALLIFAnTTNPDMLYITAPLLGM-----GAFMYSPLTNAIIIQAAPPEL 345
Cdd:cd17476   226 VLAAITVGFLIARL--PPSYIMAISMVAFLVGPILFA-TMPVHQTYWAQAFPAMivapfGMDFSFPAATIIASNAVPREY 302
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1011507046 346 RGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALM 383
Cdd:cd17476   303 QGLAGSLVNTVVNYGISIGLGIAGTVETSVNEDGADLL 340
MFS_SLC49 cd17334
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ...
28-400 4.08e-04

Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340892 [Multi-domain]  Cd Length: 407  Bit Score: 42.39  E-value: 4.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  28 LSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSIL--GSLVAMAIVTGLMSTVQSYEYG-LV 104
Cdd:cd17334    21 ITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLigAALNALGSVLKCIPLGQQPKFAlLV 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 105 LRFLLGIVSGP-VQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVA-----VHYGWQMAFLITALLPLLV 178
Cdd:cd17334   101 LGQVLNALAQVlVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAIGFLLPPVVVpppkgTKKEFGAVFYGEFGFACLL 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 179 FFLALFTVKEVQAFRKNHT-VEVQGTEPRCMSLAQSLRFVGTNRNILLLAV-----MGFFATGTTWGVTtwanlyLVKQL 252
Cdd:cd17334   181 LALVLALFPPKPKYPPSAAsARQQNSEHVILELQKSISELLRNEPFVLLAVafsimMGVFAGFSSVLAQ------ILLPF 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 253 HVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNY---LAAIVMFLFSPALLIFANTTNPD---MLYITAPLLGMGA 326
Cdd:cd17334   255 GVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRTRMFKLIgliILALGTVVCTFFMLLVDRYGLPYvtlAFYLLCGLLGFFQ 334
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1011507046 327 FMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTALMaLSISPIIGAILLSLIR 400
Cdd:cd17334   335 NSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSELLGPTPTESKYLL-WFILCTVGSCLGALFF 407
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
67-385 5.74e-04

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 41.83  E-value: 5.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  67 GLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGpVQSACLKAIGEHFSAEQRGTAVGIFMSCTSF 146
Cdd:cd17390    52 GSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKH-TQSLCKAYLSDLVSEQERSRVLGRFNAASSL 130
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 147 GITV---VNGYapFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVQAFRknhtvevqgteprcmslaqSLRFvgtnrnI 223
Cdd:cd17390   131 GFILgpvVGGH--LAETDGGFYYVALLCSAIFILNAGLVWFLLSKLWDLL-------------------LVRF------L 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 224 LLLAVMGFFATGTtwgvttwanLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRIslPRNYLAAIVMFLFSPAL 303
Cdd:cd17390   184 MGFSVLLFRSNFS---------LYLEERFDLSPKTIGYLISYSGVLGALSGFLVGRILKLY--KNNEYLLLLHSFILLAL 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 304 LIFanttnpdmLYITAPLLGMGAFMYSPL----------TNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPI---ILST 370
Cdd:cd17390   253 SLL--------GLALAPSIWLLVLCLTPLsissavlrtcSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLlsgLLQE 324
                         330
                  ....*....|....*
gi 1011507046 371 VLTATGNYQTALMAL 385
Cdd:cd17390   325 FSVSGPGLLGAVLAL 339
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
57-231 6.40e-04

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 41.55  E-value: 6.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  57 FGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGTA 136
Cdd:PRK10473   49 AGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKV 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 137 VGIFMsctsfGIT-VVNGYAPFVA----VHYGWQMAFLITALLPLLVFFLALFTVKEVQAFRK--NHTVEVQGTEP---- 205
Cdd:PRK10473  129 LSLLN-----GITcIIPVLAPVLGhlimLKFPWQSLFYTMAAMGILVLLLSLFILKETRPARApaASSKPRENSESllnr 203
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1011507046 206 --------RCMSLAQSLRFVGTNrNILLLAVMGF 231
Cdd:PRK10473  204 fflsrlviTTLSVTVILTFVNTS-PVLLMEQMGF 236
MFS_MFSD1 cd17340
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily ...
246-398 6.50e-04

Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4). The function of MFSD1 is still unknown. Its expression is affected by altered nutrient intake. During starvation, expression of MFSD1 is downregulated in anterior brain sections in mice while it is upregulated in the brainstem. In mice raised on high-fat diet, MFSD1 is specifically downregulated in brainstem and hypothalamus. MFSD1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340898 [Multi-domain]  Cd Length: 394  Bit Score: 41.49  E-value: 6.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 246 LYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISlpRN---YLAAIVMFLFSPALLIFANtTNPdmlYITAPLL 322
Cdd:cd17340   242 VFFEEKYGFSPSEAAAVNSIVYIISAAASPVFGFLVDKVG--RNilwVLIALVITLLGHLLLAFTF-VNP---LIAMVIM 315
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 323 GMGafmYSPLTNAI---IIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATGNYQTA---LMALSISPIIGAILL 396
Cdd:cd17340   316 GIG---YSMLACALwpmVPLVVPEHQLGTAYGFMQSIQNLGLAVFPIIAGSILDKKGYLLLEvffIACLCVSLIALIILY 392

                  ..
gi 1011507046 397 SL 398
Cdd:cd17340   393 LV 394
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
34-188 9.41e-04

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 41.05  E-value: 9.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  34 MPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIvS 113
Cdd:PRK11102   14 LPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGL-A 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 114 GPVQSACLKAI-GEHFSAEQrgtavgiFMSCTSFgITVVNGYAPFVA--------VHYGWQMAFLITALLPLLVFFLALF 184
Cdd:PRK11102   93 AAAASVVINALmRDMFPKEE-------FSRMMSF-VTLVMTIAPLLApiiggwllVWFSWHAIFWVLALAAILAAALVFF 164

                  ....
gi 1011507046 185 TVKE 188
Cdd:PRK11102  165 FIPE 168
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
246-326 1.01e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 40.99  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 246 LYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRIsLPRNYLAAIVMFLFSPALLIFANTTNPDMLYITA-PLLGM 324
Cdd:cd17471    21 LFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRG-GDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGvVLLSL 99

                  ..
gi 1011507046 325 GA 326
Cdd:cd17471   100 GA 101
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
260-399 1.09e-03

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 41.17  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 260 GAIMSIYGIAAVIAKPTIGFISDRISLpRNYLAAIVMFLFSPALLI--FANTTNPDMLYITAPLLGMGAFMYSPLTNAII 337
Cdd:TIGR00879  74 GLVVSIFLVGGFIGALFAGWLSDRFGR-KKSLLIIALLFVIGAILMglAAFALSVEMLIVGRVLLGIGVGIASALVPMYL 152
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1011507046 338 IQAAPPELRGTTAGFVNLFNQIGALTAPII--LSTVLTATGNYQTALMALSISPIIGAILLSLI 399
Cdd:TIGR00879 153 SEIAPKALRGALTSLYQLAITFGILVAYGFgsGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFL 216
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
57-188 1.21e-03

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 40.63  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  57 FGYALTVLPGGLLADRFGYRKSILGSLV---AMAIVTGLMSTVQSYeygLVLRFLLGIVSGPVQSACLKAIGEHFSAEQR 133
Cdd:cd17359    47 LGAAIGALFAGRLADRFGRRKTLLISAVlffISALGSAFSPNFTIF---IIARIIGGLAVGGASALVPMYIAEVAPAEIR 123
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1011507046 134 GTAVGIFMSCTSFGITVV--------NGYAPFVAVHYGWQMAFLItALLPLLVFFLALFTVKE 188
Cdd:cd17359   124 GRLVSLNQLMIVFGQLLAyivnyliaNAGGADWLGAEGWRWMLGL-EAIPAILFLLGMLFIPE 185
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
56-192 1.53e-03

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 40.68  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  56 YFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAEQRGT 135
Cdd:cd17438    44 YLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGE 123
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 136 AV----------GIFMSCTSFGITVVNGYAPFVAVHY---GWQMaFLITALLPLLVFFLALFTVKEVQAF 192
Cdd:cd17438   124 HLswlcmfwmigGLYASAMAWSIIPHYGWGFSMGTNYhfhSWRV-FVIICALPCIASIIALKFMPESPRF 192
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
57-184 1.66e-03

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 40.33  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  57 FGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVSGpVQSACLKA-IGEHFSAEQRGT 135
Cdd:cd17360    46 AGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVG-IASMTVPLyIAEAAPPRIRGR 124
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1011507046 136 AVGIFMSCTSFGITVVNGY-APFVAVHYGWQMAFLITALLPLLVFFLALF 184
Cdd:cd17360   125 LVTINVLFITGGQFVAYVInGAFSYLPGGWRWMLGLAAVPAVLQFIGLLF 174
MFS_FucP_like cd17394
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ...
33-111 1.73e-03

Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340952 [Multi-domain]  Cd Length: 401  Bit Score: 40.28  E-value: 1.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  33 LMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGL---MSTVQSYEYGLVLRFLL 109
Cdd:cd17394    21 LIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALLfipAASLRTYGLFLIALFVL 100

                  ..
gi 1011507046 110 GI 111
Cdd:cd17394   101 AS 102
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
223-400 1.79e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 40.22  E-value: 1.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 223 ILLLAVMGFFATGTTWGVTTWANLYLVkQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLpRNYLAAI--VMFLFS 300
Cdd:cd17370     1 VWLLGLVSLFADISYEMARSILPLFLV-VLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGK-RKPLVILgyGLSALA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 301 PALLIFANTTNPDMLYITAPLLGMGafMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTAT-GNYQ 379
Cdd:cd17370    79 KPLLALAGSWQLVLLLRILERLGKG--IRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLgGNYR 156
                         170       180
                  ....*....|....*....|.
gi 1011507046 380 TALMALSISPIIGAILLSLIR 400
Cdd:cd17370   157 TIFLLAAIPALLALLILLFVV 177
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
52-184 2.03e-03

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 39.85  E-value: 2.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  52 LTAFYFGYALTVLPGGLLADRFG-YRKSILGSLVAMAIVTGLMSTV---QSYEYGLVLRFLLGIVSGPVQSACLKAIGEH 127
Cdd:cd17502   209 LLPLIIGLVIGSIISGALISKTGrYKPLIVIGTILMSVGAGLLTTLtldTSKWLLIGYLILLGLGLGIGFQQPLVAVQNA 288
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1011507046 128 FSAEQRGTAVGIFMSCTSFGITVvngyapFVAVHYgwqmAFLITALLPLLVFFLALF 184
Cdd:cd17502   289 VPPADVGVATATNTFFRSLGGTL------GVAITD----VFLVALALAALAFLLSLF 335
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
41-191 2.18e-03

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 39.88  E-value: 2.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  41 LHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFL--LGIVSGPVqs 118
Cdd:PRK11043   36 LQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVqaVGVCSAAV-- 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 119 aCLKAI-GEHFSAEQrgtAVGIFMSctsfgITVVNGYAP--------FVAVHYGWQMAFLITALLPLLVFFLALFTVKEV 189
Cdd:PRK11043  114 -IWQALvIDRYPAQK---ANRVFAT-----IMPLVALSPalapllgaWLLNHFGWQAIFATLFAITLLLILPTLRLKPSK 184

                  ..
gi 1011507046 190 QA 191
Cdd:PRK11043  185 KA 186
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
31-195 2.22e-03

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 39.78  E-value: 2.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  31 SSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLG 110
Cdd:cd17436    21 SGALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLAGSFFWLVIGRAVVG 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 111 IVSGPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVvnGYA---PFVAVHYGWQMAFLITALLPLLVFFLALF--T 185
Cdd:cd17436   101 FAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILI--SYAlnyFFSNVLTGWRYMFGLAIIPAAIQFASILLlpK 178
                         170
                  ....*....|
gi 1011507046 186 VKEVQAFRKN 195
Cdd:cd17436   179 KPEVLNIKDN 188
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
35-397 3.54e-03

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 39.29  E-value: 3.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  35 PIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFL--LGIV 112
Cdd:TIGR00710  29 PEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVqaFGAS 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 113 SGPVQSACLkaIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLPLLVFFLALFTVKEVQAF 192
Cdd:TIGR00710 109 AGSVISQAL--VRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLPY 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 193 RKNHTVEVQGTEprCMSLAQSLRFVGTnrnilLLAVMGFFAtgTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVI 272
Cdd:TIGR00710 187 EARIQISTYFET--FLLLLKSKMFWGY-----ALIYGASFG--GFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIF 257
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 273 AKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFANTTNPD---MLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTT 349
Cdd:TIGR00710 258 GGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGswaMIIGPMMFVGIGNSMISSIAMAYALEDFPHVAGTAS 337
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1011507046 350 AGFVNLFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILLS 397
Cdd:TIGR00710 338 ALFGTLRLVLGAIVGYLVSLIHGNTAWPMSLSCLVLAVVSVLAFYYLS 385
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
219-402 3.80e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.12  E-value: 3.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 219 TNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLP----RNYL--A 292
Cdd:COG2211     8 SLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrrRPWIliG 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 293 AIVMFLFSPALLI---FANTTNPDMLYITAPLLGMG-AFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIIL 368
Cdd:COG2211    88 AIPLALSFVLLFTapdLSPTGKLIYALVTYLLLGLAyTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLP 167
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1011507046 369 STVLTATGNYQ----TALMALSISPIIGAILLSLIRLK 402
Cdd:COG2211   168 PPLVAAFGGDAalgyRLTALIFAVLGLLAFLLTFFGTK 205
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
55-188 4.60e-03

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 39.17  E-value: 4.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  55 FYFGYALTVLPGGLLADRFGYRKSILGSLVAM---AIVTGLMSTVQSYEYGLVLRFLLGIVSGPVQSACLKAIGEHFSAE 131
Cdd:cd17357    58 FFIGGAIGSFISAFLANRFGRKNGLLISNALLvvsSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSE 137
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1011507046 132 QRGTAVGIFMSCTSFGITVVNGYA-PFV-AVHYGWQMAFLITAlLPLLVFFLALFTVKE 188
Cdd:cd17357   138 LRGALGSLTQIGVTLGILLGQVFGlPSVlGTETLWPYLLFFPG-IPALLQLAALPFFPE 195
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
39-183 4.63e-03

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 39.01  E-value: 4.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  39 EALHFTAQQGTSYLTAFY-FGYALTVLPG----GLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYGLVLRFLLGIVS 113
Cdd:cd17363   320 CGCHLNDDEENAYLIYLVsFLGSLSVLPGnivsALLMDKIGRLKMIGGSMLLSAVCCFFLFFGNSESAMIGLQCLFCGVS 399
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 114 GPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNG-YAPFVAvhygwqmaflITALLPLLVFFLAL 183
Cdd:cd17363   400 IAAWNALDVVTVELYPTDKRATAFGFLNGLCKLAAILGNSiFGSFVG----------ITKVIPILLASAAL 460
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
228-367 4.77e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 38.69  E-value: 4.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 228 VMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFA 307
Cdd:cd17321     2 LLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA 81
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 308 NttNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPII 367
Cdd:cd17321    82 P--SLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLL 139
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
64-401 5.75e-03

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 38.96  E-value: 5.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  64 LPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQSYEYG-----LVLRFLLGI---VSGPVQSAclkAIGEHFSAEQRGT 135
Cdd:pfam05977  63 IPAGALADNFDRRKIMLAGQLLLALVSTLLTLLAGLGLLspwllLGLTFLGGIgtaLMDPAWQA---SVPELVPRRDLPA 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 136 AVGIfmscTSFGITVVNGYAPFVAvhygwqmAFLITALLPLLVFFLA----LFTVKEVQAFRKNHTVEVQGTEPRCMSLA 211
Cdd:pfam05977 140 AVAL----NSVGYNIARSVGPALG-------GVLLAAFGPAFTFALNalsyFAVIAALWRWKRAAPASPLPRERIFGAVR 208
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 212 QSLRFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYL 291
Cdd:pfam05977 209 AGLRFTAMSRELRSVLVRAFAFGLSASAVWALLPLVARDLLDGDAIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVL 288
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 292 AAIVMFLFSPALLIFAnttnpDMLYITAP--LLGMGAFMYSPLTNAIIIQAAPPE-LRGTT-AGFVNLFNqiGALTAPII 367
Cdd:pfam05977 289 LASVVTALVLLSLALA-----PNLWLAIPvlLLGGAAWITALTTLNVAVQLSVPRwVRGRAlAVYQTVFF--GGMAAGSW 361
                         330       340       350
                  ....*....|....*....|....*....|....
gi 1011507046 368 LSTVLTATGNYQTALMALSISPIIGAILLSLIRL 401
Cdd:pfam05977 362 LWGAVAEALSVTGALLGAAAALLAGAAAGLRFRL 395
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
72-396 5.85e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 38.76  E-value: 5.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  72 RFGYRKS-ILGSLVAMAIVTGLMSTVQSYEYGL--------VLRFLLGIV-----SGPVQSACLKAIGEHFSAEQRGTAV 137
Cdd:cd17313    64 RIGRRRPfILVGAPLAALGLILIPNAADIGLALgdgprtwaLVLFVLGIVlldfaMNVCQGPVRALLPDLVPPEQRSKAN 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 138 GIFMSCTSFG----------ITVVNGYAPFVAVHYgwQMAFLITALLPLLVFFLALFTVKEVQaFRKNHTVEVQGTEPRC 207
Cdd:cd17313   144 GIINFMGGLGgvlgyllgaiLWDHNWFGFALGGNL--KVPFYIGAIILLVCVLVTLFFVKEPP-LSPEAGEHSENPSLGE 220
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 208 MSLAQSLRFVGTNRNILLLAV------MGFFATGTTWGVTTWANLYLVKQLHVTPI-----FAGAIMSIYGIAAVIAKPT 276
Cdd:cd17313   221 VLKSLLKLLKIMPRSLLRLLLviffwwIAFFPFELFFTDYMGEEVYHGTSAASSHYgagvrMGAWGLLIFSLAFLIFSLP 300
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 277 IGFISDRISLPRNYLAAIVMFLFSPALLIFanTTNPDMLYITAPLLGMGAFMYSPLTNAIIIQAAPPELR--GTTAGFVN 354
Cdd:cd17313   301 IGKLGKKIGRKKVYLIGLVLFAVGMALMAL--VHNVTVALVLFALGGIGWATININPYPLVSDYHSESGRgqGTDTGLLN 378
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1011507046 355 LFNQIGALTAPIILSTVLTATGNYQTALMALSISPIIGAILL 396
Cdd:cd17313   379 LAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGAL 420
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
24-159 6.04e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 38.73  E-value: 6.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  24 FVMRLSWSSLMPIVNEALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTVQ--SYEY 101
Cdd:COG2211   242 LALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWL 321
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 102 GLVLRFLLGIVSGPVQS---ACLKAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVA 159
Cdd:COG2211   322 LLVLAALAGIGLGAILVlpwAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALA 382
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
39-184 6.38e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 38.31  E-value: 6.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  39 EALHFTAQQGTSYLTAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLMSTV---QSYEYGLVLRFLLGIVSGP 115
Cdd:cd17321   197 GVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLgadSSVWLLLPGLVLLGLGLGL 276
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 116 VQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGITV-----------------------VNGYAPFVAVHYGWQMAFLITA 172
Cdd:cd17321   277 FATPLTNAALSSVPKEKAGAASGILNTARQLGGALgvallgalltaglsanlgdsgvaALLSAAAAAFAAGFHLAFLVAA 356
                         170
                  ....*....|..
gi 1011507046 173 LLPLLVFFLALF 184
Cdd:cd17321   357 ALALLAALLALL 368
MFS_SLC37A1_2 cd17344
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ...
43-181 6.92e-03

Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340902 [Multi-domain]  Cd Length: 400  Bit Score: 38.45  E-value: 6.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  43 FTAQQGTSYL----TAFYFGYALTVLPGGLLADRFGYRKSILGSLVAMAIVTGLM-----STVQSYEYGLVLRFLLGIVS 113
Cdd:cd17344    55 FDGKNGTELLgaldSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFglgyyWNIHSLWYFVVVQILAGLFQ 134
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1011507046 114 GPVQSACLKAIGEHFSAEQRGTAVGIFMSCTSFGiTVVNGYAPFVAVHYGWQMAF----LITALLPLLVFFL 181
Cdd:cd17344   135 STGWPSVVACVGNWFGKGKRGLIMGIWNSHTSVG-NILGSLIAGIFVSSAWGLSFivpgIIIAAMGVLVFLF 205
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
250-402 7.49e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 38.31  E-value: 7.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 250 KQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAivMFLFSPALLIFANTTNPDMLYITAPLLGMGAFMY 329
Cdd:cd17477    24 EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAG--AAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGL 101
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1011507046 330 SPLTNAIIIQAAPPELRGTTAGFVNLFNQIGALTAPIILSTVLTATgnyQTALMALSISPIIGAILLSLIRLK 402
Cdd:cd17477   102 FVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAG---ALPFLIAAVLLLLALVPLLLTRRA 171
gph TIGR00792
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ...
163-315 7.96e-03

sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273270  Cd Length: 437  Bit Score: 38.39  E-value: 7.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 163 GWQMAFLITALLPLLVFFLALFTVKEVQ-AFRKNHTVEVqgteprcmSLAQSLRFVGTNRNILLLAVMgFFATGTTWGVT 241
Cdd:TIGR00792 171 GWFMFALVLALIGVVSLIICFFGTKERYsEIPKNIEKKL--------SLKQIFKALFKNDQLLILCLA-YLFYNLAFNIK 241
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1011507046 242 TWANLYLVKQLHVTPIFAGAIMSIYGIAAVIAKPTIGFISDRISLPRNYLAAIVMFLFSPALLIFANTTNPDML 315
Cdd:TIGR00792 242 NGVQVYYFTYVLGDPELFSYMGSIAIVAGLIGVLLFPRLVKKFGRKILFAGGILLMVLGYLIFFFAGSNLPLIL 315
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
45-181 9.33e-03

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 38.19  E-value: 9.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046  45 AQQGtSYLTAFYFGYALTVLPGGLLADRFGYRKSIlGSLVAMAIVTGLMSTVQSYEYG---LVLRFLLGIVSGPVQSACL 121
Cdd:TIGR00894  76 ALQG-LILSSHFYGQIIIQIPVGYLAGKYVFKWSI-GIGMFLSSVISIVIPWAAGGGIalvVFCRVIQGLAQGSVSPATH 153
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011507046 122 KAIGEHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHY-GWQMAFLITALLPLLVFFL 181
Cdd:TIGR00894 154 KIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWgGWPMIFYVFGIVGCAWSLL 214
MFS_AmpG_like cd17486
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner ...
126-328 9.35e-03

AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341039 [Multi-domain]  Cd Length: 387  Bit Score: 37.96  E-value: 9.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 126 EHFSAEQRGTAVGIFMSCTSFGITVVNGYAPFVAVHYGWQMAFLITALLpLLVFFLALFTVKEVQAFRKNHTVEVQGTEP 205
Cdd:cd17486   118 EALEDKEQGAGAGVRVNGYRIGMLVAGAGALYLADSLSWSAVYLIMAAL-MGPGILATLFAPEPPRTDPPANSLSETVVA 196
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011507046 206 RCMSLAQslrFVGTNRNILLLAVMGFFATGTTWGVTTWANLYLVKQLHVTPIfaGAIMSIYGIAAVIAKPTI-GFISDRI 284
Cdd:cd17486   197 FFAPFKD---FFGQPGALLILAFILLYKLGDAMLGAMATPFLLDLGFTKTEI--GAVYKTVGLIATIVGGLLgGFLMSRL 271
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1011507046 285 SLPRNYLAAIVMFLFSPALLIFANTTNPDMLYITAPL--------LGMGAFM 328
Cdd:cd17486   272 GLKRSLWLFGILQALSNLGFIYLAHAGPNLTLLVAAVavenfgggLGTTAFV 323
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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