|
Name |
Accession |
Description |
Interval |
E-value |
| YnbB |
COG4100 |
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion ... |
1-411 |
0e+00 |
|
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 443276 Cd Length: 409 Bit Score: 713.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 1 MTVEEIRQQALELAEKEFKKFEPVALYNTKKVLEAFKECQLSDYHFNGTSGYGYNDVGREKLDEVFAHVFKGERAIVRPH 80
Cdd:COG4100 1 EEILELVEEAEEELAPVFKEIDEIAEYNQLKVLKAFQKNRVSDSHFAGTTGYGYDDIGRDTLERVYADVFGAEDALVRPQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 81 FVSGTHALATTLQAILgngSKGKEFVYAVGQPYDTMQSVIGASRHVPGSLTEQDFIYKEVPLV-NNTYDLEGIRQAITKD 159
Cdd:COG4100 81 IVSGTHAIALALFGVL---RPGDELLSITGKPYDTLEEVIGIRGEGQGSLKEFGISYRQVPLTeDGKIDLEAIKKAINEK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 160 TRVVVIQRSRGYSTREPLSVEDIGIIVKAVKEVNPETITFVDNCYGEFTETREPLEVGADIMAGSLIKNAGGGIAPTGGY 239
Cdd:COG4100 158 TKMVLIQRSRGYSWRPSLTIEEIGEIIKFVKSINPDVICFVDNCYGEFVETREPTEVGADLMAGSLIKNPGGGLAPTGGY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 240 VVGRDDLVEQVGYQLTAPGLGDHMGSYAPGYRLFFQGLFLAPHVVLQALKGAVYTAAVGTLLGYEVFPKVDAPRFDLIQA 319
Cdd:COG4100 238 IAGRKDLVELAAYRLTAPGIGKEVGATLGQNRLMYQGLFLAPHVVGEALKGAIFAAAVFEKLGFEVSPKPDEPRSDIIQA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 320 INLHGPEEMEYFCRGMQAYSPVDAHVHPIPGDMPGYEDKIIMAGGTFVQGSSIELSADGPVRPPYTIFMQGGLVFEHSML 399
Cdd:COG4100 318 IKLGSPEKLIAFCQGIQKASPVDSHVTPEPWDMPGYEDPVIMAAGTFIQGSSIELSADGPIREPYIVYLQGGLTYEHVKL 397
|
410
....*....|..
gi 1011508192 400 GILGAAEEILKH 411
Cdd:COG4100 398 AILSALQALLEK 409
|
|
| Met_gamma_lyase |
pfam06838 |
Methionine gamma-lyase; This is a putative pyridoxal 5'-phosphate-dependent methionine ... |
3-409 |
0e+00 |
|
Methionine gamma-lyase; This is a putative pyridoxal 5'-phosphate-dependent methionine gamma-lyase enzyme involved in methionine catabolism.
Pssm-ID: 429146 Cd Length: 405 Bit Score: 571.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 3 VEEIRQQALELAEKEFKKFEPVALYNTKKVLEAFKECQLSDYHFNGTSGYGYNDVGREKLDEVFAHVFKGERAIVRPHFV 82
Cdd:pfam06838 1 VLKLYEQAENDILPIFKKIDEIVEFNQLKVLNAFQEERVSDHHFTGSTGYGYDDIGRDTLDRVYARVFGAEAALVRPQFV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 83 SGTHALATTLQAILGNGSkgkEFVYAVGQPYDTMQSVIGASRHVPGSLTEQDFIYKEVPLVNN-TYDLEGIRQAITKDTR 161
Cdd:pfam06838 81 SGTHAIATALFGVLRPGD---ELLYITGSPYDTLEEVIGIRGEGQGSLKDFGIGYREVPLLEDgKVDWEAIKTAITPKTK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 162 VVVIQRSRGYSTREPLSVEDIGIIVKAVKEVNPETITFVDNCYGEFTETREPLEVGADIMAGSLIKNAGGGIAPTGGYVV 241
Cdd:pfam06838 158 LILIQRSKGYSWRPSLTIAEIKEIIKFVKEINPDVIVFVDNCYGEFVETKEPTHVGADLIAGSLIKNPGGGIAPTGGYIA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 242 GRDDLVEQVGYQLTAPGLGDHMGSYAPGYRLFFQGLFLAPHVVLQALKGAVYTAAVGTLLGYEVFPKVDAPRFDLIQAIN 321
Cdd:pfam06838 238 GKADLVEQASYRLTAPGIGREGGATFGSLRLMYQGLFLAPHVVGEALKGAHLTARVLELLGFEVLPKYNEKRTDLIQAVK 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 322 LHGPEEMEYFCRGMQAYSPVDAHVHPIPGDMPGYEDKIIMAGGTFVQGSSIELSADGPVRPPYTIFMQGGLVFEHSMLGI 401
Cdd:pfam06838 318 FGDKEKLIAFCQAIQAASPIDSHVDPEPADMPGYEDDVIMAAGTFIQGSSIELSADGPIREPYIAYVQGGLTYEHVKIAV 397
|
....*...
gi 1011508192 402 LGAAEEIL 409
Cdd:pfam06838 398 LIALDAIV 405
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
139-265 |
1.17e-10 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 62.92 E-value: 1.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 139 EVPLVNnTYDLEGIRQAITKDTRVVVIQrsrgySTREP-LSVEDIGIIVKAVKEVNPETITFVDNCYGEFTETRePLEVG 217
Cdd:PRK06234 130 EVTFVD-TSNLEEVRNALKANTKVVYLE-----TPANPtLKVTDIKAISNIAHENNKECLVFVDNTFCTPYIQR-PLQLG 202
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1011508192 218 ADIMAGSLIKNAGGGIAPTGGYVVGRDDLVEQVGYQltapGLGDHMGS 265
Cdd:PRK06234 203 ADVVVHSATKYLNGHGDVIAGFVVGKEEFINQVKLF----GIKDMTGS 246
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
59-247 |
1.32e-06 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 49.89 E-value: 1.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 59 REKLDEVFAHVFKGERAIVrphFVSGTHALATTLQAILGNGSKgkefVYAVGQPYDTMQSVIgaSRHVPGSLTEQDFIyk 138
Cdd:cd00614 42 VDALEKKLAALEGGEAALA---FSSGMAAISTVLLALLKAGDH----VVASDDLYGGTYRLF--ERLLPKLGIEVTFV-- 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 139 evplvnNTYDLEGIRQAITKDTRVVVIQrsrgySTREP-LSVEDIGIIVKAVKEVNPetITFVDNCYGEFTETRePLEVG 217
Cdd:cd00614 111 ------DPDDPEALEAAIKPETKLVYVE-----SPTNPtLKVVDIEAIAELAHEHGA--LLVVDNTFATPYLQR-PLELG 176
|
170 180 190
....*....|....*....|....*....|
gi 1011508192 218 ADIMAGSLIKNAGGGIAPTGGYVVGRDDLV 247
Cdd:cd00614 177 ADIVVHSATKYIGGHSDVIAGVVVGSGEAL 206
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| YnbB |
COG4100 |
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion ... |
1-411 |
0e+00 |
|
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 443276 Cd Length: 409 Bit Score: 713.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 1 MTVEEIRQQALELAEKEFKKFEPVALYNTKKVLEAFKECQLSDYHFNGTSGYGYNDVGREKLDEVFAHVFKGERAIVRPH 80
Cdd:COG4100 1 EEILELVEEAEEELAPVFKEIDEIAEYNQLKVLKAFQKNRVSDSHFAGTTGYGYDDIGRDTLERVYADVFGAEDALVRPQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 81 FVSGTHALATTLQAILgngSKGKEFVYAVGQPYDTMQSVIGASRHVPGSLTEQDFIYKEVPLV-NNTYDLEGIRQAITKD 159
Cdd:COG4100 81 IVSGTHAIALALFGVL---RPGDELLSITGKPYDTLEEVIGIRGEGQGSLKEFGISYRQVPLTeDGKIDLEAIKKAINEK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 160 TRVVVIQRSRGYSTREPLSVEDIGIIVKAVKEVNPETITFVDNCYGEFTETREPLEVGADIMAGSLIKNAGGGIAPTGGY 239
Cdd:COG4100 158 TKMVLIQRSRGYSWRPSLTIEEIGEIIKFVKSINPDVICFVDNCYGEFVETREPTEVGADLMAGSLIKNPGGGLAPTGGY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 240 VVGRDDLVEQVGYQLTAPGLGDHMGSYAPGYRLFFQGLFLAPHVVLQALKGAVYTAAVGTLLGYEVFPKVDAPRFDLIQA 319
Cdd:COG4100 238 IAGRKDLVELAAYRLTAPGIGKEVGATLGQNRLMYQGLFLAPHVVGEALKGAIFAAAVFEKLGFEVSPKPDEPRSDIIQA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 320 INLHGPEEMEYFCRGMQAYSPVDAHVHPIPGDMPGYEDKIIMAGGTFVQGSSIELSADGPVRPPYTIFMQGGLVFEHSML 399
Cdd:COG4100 318 IKLGSPEKLIAFCQGIQKASPVDSHVTPEPWDMPGYEDPVIMAAGTFIQGSSIELSADGPIREPYIVYLQGGLTYEHVKL 397
|
410
....*....|..
gi 1011508192 400 GILGAAEEILKH 411
Cdd:COG4100 398 AILSALQALLEK 409
|
|
| Met_gamma_lyase |
pfam06838 |
Methionine gamma-lyase; This is a putative pyridoxal 5'-phosphate-dependent methionine ... |
3-409 |
0e+00 |
|
Methionine gamma-lyase; This is a putative pyridoxal 5'-phosphate-dependent methionine gamma-lyase enzyme involved in methionine catabolism.
Pssm-ID: 429146 Cd Length: 405 Bit Score: 571.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 3 VEEIRQQALELAEKEFKKFEPVALYNTKKVLEAFKECQLSDYHFNGTSGYGYNDVGREKLDEVFAHVFKGERAIVRPHFV 82
Cdd:pfam06838 1 VLKLYEQAENDILPIFKKIDEIVEFNQLKVLNAFQEERVSDHHFTGSTGYGYDDIGRDTLDRVYARVFGAEAALVRPQFV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 83 SGTHALATTLQAILGNGSkgkEFVYAVGQPYDTMQSVIGASRHVPGSLTEQDFIYKEVPLVNN-TYDLEGIRQAITKDTR 161
Cdd:pfam06838 81 SGTHAIATALFGVLRPGD---ELLYITGSPYDTLEEVIGIRGEGQGSLKDFGIGYREVPLLEDgKVDWEAIKTAITPKTK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 162 VVVIQRSRGYSTREPLSVEDIGIIVKAVKEVNPETITFVDNCYGEFTETREPLEVGADIMAGSLIKNAGGGIAPTGGYVV 241
Cdd:pfam06838 158 LILIQRSKGYSWRPSLTIAEIKEIIKFVKEINPDVIVFVDNCYGEFVETKEPTHVGADLIAGSLIKNPGGGIAPTGGYIA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 242 GRDDLVEQVGYQLTAPGLGDHMGSYAPGYRLFFQGLFLAPHVVLQALKGAVYTAAVGTLLGYEVFPKVDAPRFDLIQAIN 321
Cdd:pfam06838 238 GKADLVEQASYRLTAPGIGREGGATFGSLRLMYQGLFLAPHVVGEALKGAHLTARVLELLGFEVLPKYNEKRTDLIQAVK 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 322 LHGPEEMEYFCRGMQAYSPVDAHVHPIPGDMPGYEDKIIMAGGTFVQGSSIELSADGPVRPPYTIFMQGGLVFEHSMLGI 401
Cdd:pfam06838 318 FGDKEKLIAFCQAIQAASPIDSHVDPEPADMPGYEDDVIMAAGTFIQGSSIELSADGPIREPYIAYVQGGLTYEHVKIAV 397
|
....*...
gi 1011508192 402 LGAAEEIL 409
Cdd:pfam06838 398 LIALDAIV 405
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
139-265 |
1.17e-10 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 62.92 E-value: 1.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 139 EVPLVNnTYDLEGIRQAITKDTRVVVIQrsrgySTREP-LSVEDIGIIVKAVKEVNPETITFVDNCYGEFTETRePLEVG 217
Cdd:PRK06234 130 EVTFVD-TSNLEEVRNALKANTKVVYLE-----TPANPtLKVTDIKAISNIAHENNKECLVFVDNTFCTPYIQR-PLQLG 202
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1011508192 218 ADIMAGSLIKNAGGGIAPTGGYVVGRDDLVEQVGYQltapGLGDHMGS 265
Cdd:PRK06234 203 ADVVVHSATKYLNGHGDVIAGFVVGKEEFINQVKLF----GIKDMTGS 246
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
59-247 |
1.32e-06 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 49.89 E-value: 1.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 59 REKLDEVFAHVFKGERAIVrphFVSGTHALATTLQAILGNGSKgkefVYAVGQPYDTMQSVIgaSRHVPGSLTEQDFIyk 138
Cdd:cd00614 42 VDALEKKLAALEGGEAALA---FSSGMAAISTVLLALLKAGDH----VVASDDLYGGTYRLF--ERLLPKLGIEVTFV-- 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 139 evplvnNTYDLEGIRQAITKDTRVVVIQrsrgySTREP-LSVEDIGIIVKAVKEVNPetITFVDNCYGEFTETRePLEVG 217
Cdd:cd00614 111 ------DPDDPEALEAAIKPETKLVYVE-----SPTNPtLKVVDIEAIAELAHEHGA--LLVVDNTFATPYLQR-PLELG 176
|
170 180 190
....*....|....*....|....*....|
gi 1011508192 218 ADIMAGSLIKNAGGGIAPTGGYVVGRDDLV 247
Cdd:cd00614 177 ADIVVHSATKYIGGHSDVIAGVVVGSGEAL 206
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
114-220 |
9.87e-06 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 47.39 E-value: 9.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 114 DTMQSVIGASRHV--PGSLTE--QDFIYKEVPLVNNT---YDL---EGIRQAITKDTRVVVIQrSRGYSTREplsVEDIG 183
Cdd:PRK08114 92 NAILAFVEQGDHVlmTGTAYEptQDFCSKILSKLGVTttwFDPligADIAKLIQPNTKVVFLE-SPGSITME---VHDVP 167
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1011508192 184 IIVKAVKEVNPETITFVDNCYGE---FtetrEPLEVGADI 220
Cdd:PRK08114 168 AIVAAVRSVNPDAVIMIDNTWAAgvlF----KALDFGIDI 203
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
40-258 |
9.90e-06 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 47.23 E-value: 9.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 40 QLSDYHFNG---TSGYGYNDVG---REKLDEVFAHVFKGERAIVrphFVSGTHALATTLQAILGNGSKgkefVYAVGQPY 113
Cdd:pfam01053 24 LTSTYVFDFageEGGYDYSRSGnptRDVLEERIAALEGGAAALA---FSSGMAAITAAILALLKAGDH----IVATDDLY 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 114 DTMQSVIgaSRHVPGSLTEQDFIykevplvnNTYDLEGIRQAITKDTRVVVIQrsrgySTREP-LSVEDIGIIVKAVKEV 192
Cdd:pfam01053 97 GGTYRLF--NKVLPRFGIEVTFV--------DTSDPEDLEAAIKPNTKAVYLE-----TPTNPlLKVVDIEAIAKLAKKH 161
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1011508192 193 NpeTITFVDNCYGEFTETRePLEVGADIMAGSLIKNAGGGIAPTGGYVVGRD-DLVEQVGYQLTAPG 258
Cdd:pfam01053 162 G--ILVVVDNTFASPYLQR-PLDLGADIVVHSATKYIGGHSDVVGGVIVVNGeELGKELYFLQNATG 225
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
145-249 |
2.77e-05 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 45.81 E-value: 2.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 145 NTYDLEGIRQAITKDTRVVVIqrsrgystrE-P----LSVEDIGIIVKAVKEVNPetITFVDNCYGefteT----RePLE 215
Cdd:COG0626 129 DPTDLAAVEAAIRPNTKLVFL---------EtPsnptLEVVDIAAIAAIAHAAGA--LLVVDNTFA----TpllqR-PLE 192
|
90 100 110
....*....|....*....|....*....|....
gi 1011508192 216 VGADIMAGSLIKNAGGGIAPTGGYVVGRDDLVEQ 249
Cdd:COG0626 193 LGADIVVHSATKYLGGHSDVLGGAVVGRDEELAE 226
|
|
| KBL_like |
cd06454 |
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ... |
60-289 |
5.34e-05 |
|
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.
Pssm-ID: 99747 [Multi-domain] Cd Length: 349 Bit Score: 44.86 E-value: 5.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 60 EKLDEVFAHVFKGERAIVrphFVSGTHALATTLQAILGNGSkgkeFVYAvgqpyDTMQ--SVI------GASRHvpgslt 131
Cdd:cd06454 49 EELEEELAEFHGKEAALV---FSSGYAANDGVLSTLAGKGD----LIIS-----DSLNhaSIIdgirlsGAKKR------ 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 132 eqdfIYKEvplvNNTYDLEG-IRQAITKDTRVVVIQRSRgYSTREplSVEDIGIIVKAVKEVNpeTITFVDNC-----YG 205
Cdd:cd06454 111 ----IFKH----NDMEDLEKlLREARRPYGKKLIVTEGV-YSMDG--DIAPLPELVDLAKKYG--AILFVDEAhsvgvYG 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 206 EF---TETREPLEVGADIMAGSLIKnAGGGIaptGGYVVGRDDLVeqvgyqltapglgDHMGSYAPGYrlffqgLF---L 279
Cdd:cd06454 178 PHgrgVEEFGGLTDDVDIIMGTLGK-AFGAV---GGYIAGSKELI-------------DYLRSYARGF------IFstsL 234
|
250
....*....|
gi 1011508192 280 APHVVLQALK 289
Cdd:cd06454 235 PPAVAAAALA 244
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
148-265 |
6.32e-05 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 44.79 E-value: 6.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 148 DLEGIRQAITKDTRVVVIQRSRGYSTReplsVEDIGIIVKAVKEVNPETItfVDNCYGEFTETRePLEVGADIMAGSLIK 227
Cdd:PRK07503 139 DPAALKAAISDKTRMVYFETPANPNMR----LVDIAAVAEIAHGAGAKVV--VDNTYCTPYLQR-PLELGADLVVHSATK 211
|
90 100 110
....*....|....*....|....*....|....*...
gi 1011508192 228 NAGGGIAPTGGYVVGRDDLVEQVGYQltapGLGDHMGS 265
Cdd:PRK07503 212 YLGGHGDITAGLVVGGKALADRIRLE----GLKDMTGA 245
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
141-258 |
1.79e-04 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 43.54 E-value: 1.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 141 PLVNNTYDLEGIRQAITKDTRVVVIQrsrgySTREPLSVE-DIGIIVKAVKEVNPETItfVDNCYgeFTET-REPLEVGA 218
Cdd:PRK08247 118 FVYVNTASLKAIEQAITPNTKAIFIE-----TPTNPLMQEtDIAAIAKIAKKHGLLLI--VDNTF--YTPVlQRPLEEGA 188
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1011508192 219 DIMAGSLIKNAGGGIAPTGGYVVGRD-DLVEQVGYQLTAPG 258
Cdd:PRK08247 189 DIVIHSATKYLGGHNDVLAGLVVAKGqELCERLAYYQNAAG 229
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
122-256 |
2.98e-04 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 42.68 E-value: 2.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 122 ASRHVPGSlTEQDF--IYK----EVPLVNNTyDLEGIRQAITKDTRVVVIQrsrgySTREPLS-VEDIGIIVKAVKEVNp 194
Cdd:PRK08133 105 SSRSLFGS-TVSLFekIFArfgiETTFVDLT-DLDAWRAAVRPNTKLFFLE-----TPSNPLTeLADIAALAEIAHAAG- 176
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1011508192 195 eTITFVDNCYGEFTETRePLEVGADIMAGSLIKNAGGGIAPTGGYVVGRDDLVEQV-GYQLTA 256
Cdd:PRK08133 177 -ALLVVDNCFCTPALQQ-PLKLGADVVIHSATKYLDGQGRVLGGAVVGSKELMEEVfGFLRTA 237
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
42-259 |
8.12e-04 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 41.51 E-value: 8.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 42 SDYHFNG---TSGYGYNDVG---REKLDEVFAHVFKGERAIVRphfVSGTHALATTLQAILgngskgkefvyavgQPYDT 115
Cdd:PRK08776 39 SNFSFDGfgnKRQYDYTRSGnptRDLLGEALAELEGGAGGVIT---ATGMGAINLVLNALL--------------QPGDT 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 116 M---QSVIGASRHVPGSLTEQ-DFIYKEVPLVnntyDLEGIRQAITKDTRVVVIQrsrgySTREPL-SVEDIGIIVKAVK 190
Cdd:PRK08776 102 LvvpHDAYGGSWRLFNALAKKgHFALITADLT----DPRSLADALAQSPKLVLIE-----TPSNPLlRITDLRFVIEAAH 172
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 191 EVNpeTITFVDNCYGEfTETREPLEVGADIMAGSLIKNAGGGIAPTGGYVVGRD-DLVEQVGYQLTAPGL 259
Cdd:PRK08776 173 KVG--ALTVVDNTFLS-PALQKPLEFGADLVLHSTTKYINGHSDVVGGAVVARDaELHQQLVWWANALGL 239
|
|
| PRK00451 |
PRK00451 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPA; |
139-250 |
7.22e-03 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
Pssm-ID: 234769 [Multi-domain] Cd Length: 447 Bit Score: 38.58 E-value: 7.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 139 EVPLVNNTYDLEGIRQAITKDTRVVVIQRSRGYSTreplsVEDIGIIVKAVKEVNPETITFVDncygeftetrePL---- 214
Cdd:PRK00451 184 EVPYEDGVTDLEALEAAVDDDTAAVVVQYPNFFGV-----IEDLEEIAEIAHAGGALFIVGVD-----------PVslgl 247
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1011508192 215 -----EVGADIMAG-------SLikNAGGgiaPTGGYVVGRDDLVEQV 250
Cdd:PRK00451 248 lkppgEYGADIVVGegqplgiPL--SFGG---PYLGFFATRKKLVRQM 290
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
1-250 |
9.36e-03 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 38.06 E-value: 9.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 1 MTVEEIRQqalelAEKEFKKFEPVALYNTKKVLEAFKECqLSDYHFNGTsgygyndvgrekldevfAHVFKGERAIVrph 80
Cdd:pfam00155 14 DTLPAVAK-----AEKDALAGGTRNLYGPTDGHPELREA-LAKFLGRSP-----------------VLKLDREAAVV--- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 81 FVSGTHALATTLQAILGNgsKGKEFVyaVGQP-YDTMQSVIGASRHVPgslteqdFIYKEVPLVNNTYDLEGIRQAITKD 159
Cdd:pfam00155 68 FGSGAGANIEALIFLLAN--PGDAIL--VPAPtYASYIRIARLAGGEV-------VRYPLYDSNDFHLDFDALEAALKEK 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011508192 160 TRVVVIQrsrgySTREP----LSVEDIGIIVKAVKEVNpeTITFVDNCYGEF-------TETREPLEVGADIM-AGSLIK 227
Cdd:pfam00155 137 PKVVLHT-----SPHNPtgtvATLEELEKLLDLAKEHN--ILLLVDEAYAGFvfgspdaVATRALLAEGPNLLvVGSFSK 209
|
250 260
....*....|....*....|....*.
gi 1011508192 228 N---AGGGIaptgGYVVGRDDLVEQV 250
Cdd:pfam00155 210 AfglAGWRV----GYILGNAAVISQL 231
|
|
| |
