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Conserved domains on  [gi|1011722463|ref|WP_062566269|]
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MULTISPECIES: Lrp/AsnC family transcriptional regulator [Pseudoalteromonas]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-141 8.74e-52

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 161.10  E-value: 8.74e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011722463   1 MKLDKKDQQLLNALQDNARTSVSELAHSVSLSDTPCLRRIKKLESANVISGYHAAINPKAVDLNVSVYAFVRLNQNSVaa 80
Cdd:COG1522     1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRL-- 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011722463  81 aEQFEQQVEKLDHVLECSVISGSYDYLLKIVAADLESYESFVKHKLGSIDCIANIESTVVL 141
Cdd:COG1522    79 -DEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-141 8.74e-52

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 161.10  E-value: 8.74e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011722463   1 MKLDKKDQQLLNALQDNARTSVSELAHSVSLSDTPCLRRIKKLESANVISGYHAAINPKAVDLNVSVYAFVRLNQNSVaa 80
Cdd:COG1522     1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRL-- 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011722463  81 aEQFEQQVEKLDHVLECSVISGSYDYLLKIVAADLESYESFVKHKLGSIDCIANIESTVVL 141
Cdd:COG1522    79 -DEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 3-112 5.43e-36

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 119.93  E-value: 5.43e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011722463    3 LDKKDQQLLNALQDNARTSVSELAHSVSLSDTPCLRRIKKLESANVISGYHAAINPKAVDLNVSVYAFVRLNQNSvaAAE 82
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPD--KLE 78

                           90       100       110
                   ....*....|....*....|....*....|
gi 1011722463   83 QFEQQVEKLDHVLECSVISGSYDYLLKIVA 112
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
3-118 3.62e-30

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 107.15  E-value: 3.62e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011722463   3 LDKKDQQLLNALQDNARTSVSELAHSVSLSDTPCLRRIKKLESANVISGYHAAINPKAVDLNVSVYAFVRLNQNSVAAAE 82
Cdd:PRK11169   12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFE 91

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1011722463  83 QFEQQVEKLDHVLECSVISGSYDYLLKIVAADLESY 118
Cdd:PRK11169   92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAY 127
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 71-143 6.85e-20

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 77.95  E-value: 6.85e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1011722463  71 VRLNQNSvaAAEQFEQQVEKLDHVLECSVISGSYDYLLKIVAADLESYESFVKHKLGSIDCIANIESTVVLKQ 143
Cdd:pfam01037   3 VKLEPGH--ALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 4-52 1.11e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 38.43  E-value: 1.11e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1011722463   4 DKKDQQLLNALQDNARTsVSELAHSVSLSDTPCLRRIKKLESANVISGY 52
Cdd:cd00090     6 DPTRLRILRLLLEGPLT-VSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-141 8.74e-52

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 161.10  E-value: 8.74e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011722463   1 MKLDKKDQQLLNALQDNARTSVSELAHSVSLSDTPCLRRIKKLESANVISGYHAAINPKAVDLNVSVYAFVRLNQNSVaa 80
Cdd:COG1522     1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRL-- 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1011722463  81 aEQFEQQVEKLDHVLECSVISGSYDYLLKIVAADLESYESFVKHKLGSIDCIANIESTVVL 141
Cdd:COG1522    79 -DEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 3-112 5.43e-36

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 119.93  E-value: 5.43e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011722463    3 LDKKDQQLLNALQDNARTSVSELAHSVSLSDTPCLRRIKKLESANVISGYHAAINPKAVDLNVSVYAFVRLNQNSvaAAE 82
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPD--KLE 78

                           90       100       110
                   ....*....|....*....|....*....|
gi 1011722463   83 QFEQQVEKLDHVLECSVISGSYDYLLKIVA 112
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
3-118 3.62e-30

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 107.15  E-value: 3.62e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011722463   3 LDKKDQQLLNALQDNARTSVSELAHSVSLSDTPCLRRIKKLESANVISGYHAAINPKAVDLNVSVYAFVRLNQNSVAAAE 82
Cdd:PRK11169   12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFE 91

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1011722463  83 QFEQQVEKLDHVLECSVISGSYDYLLKIVAADLESY 118
Cdd:PRK11169   92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAY 127
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 71-143 6.85e-20

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 77.95  E-value: 6.85e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1011722463  71 VRLNQNSvaAAEQFEQQVEKLDHVLECSVISGSYDYLLKIVAADLESYESFVKHKLGSIDCIANIESTVVLKQ 143
Cdd:pfam01037   3 VKLEPGH--ALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-143 3.69e-16

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 70.51  E-value: 3.69e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1011722463   1 MKLDKKDQQLLNALQDNARTSVSELAHSVSLSDTPCLRRIKKLESANVISGYHAAINPKAvdLNVSVYAFVRLNQNSVAA 80
Cdd:PRK11179    5 YQIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQ--LGYDVCCFIGIILKSAKD 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1011722463  81 AEQFEQQVEKLDHVLECSVISGSYDYLLKIVAADLESYESFVKHKLGSIDCIANIESTVVLKQ 143
Cdd:PRK11179   83 YPSALAKLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLISLQN 145
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
4-44 6.46e-15

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 64.31  E-value: 6.46e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1011722463   4 DKKDQQLLNALQDNARTSVSELAHSVSLSDTPCLRRIKKLE 44
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
5-49 7.71e-12

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 56.67  E-value: 7.71e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1011722463   5 KKDQQLLNALQDNARTSVSELAHSVSLSDTPCLRRIKKLESANVI 49
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 4-52 1.11e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 38.43  E-value: 1.11e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1011722463   4 DKKDQQLLNALQDNARTsVSELAHSVSLSDTPCLRRIKKLESANVISGY 52
Cdd:cd00090     6 DPTRLRILRLLLEGPLT-VSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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