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Conserved domains on  [gi|1020085945|ref|WP_063222700|]
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MULTISPECIES: nitrate transporter NarK [Bacillus]

Protein Classification

nitrate/nitrite transporter( domain architecture ID 13023816)

nitrate/nitrite transporter is a major facilitator superfamily (MFS) transporter that facilitates the transport of nitrate (import)/nitrite (export)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
8-375 5.12e-90

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 276.44  E-value: 5.12e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945   8 LSLQTSNLVIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFY 87
Cdd:cd17341     1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  88 ISVA-NSMMDLIIGGLFVGIGGAVFSVGVTSLPKYFPKE-SHGFVNGIYGVGNAGTAITSFLAPVIA-------TSVGWR 158
Cdd:cd17341    81 LALAvSSYWGLLVLGFLLGFAGANFASGQPWASFWFPKEkIGGAAGGIAGAGNMGVAVSQLLAPLIAgaivfdgGFVGWR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 159 TTVQCYLVLLAAFALMNFLLGDR--KEKKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDK 236
Cdd:cd17341   161 NAFFVPGILLAIAAVLVLLFGDDlpTGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 237 VDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAF-----CAGIGNGTI 311
Cdd:cd17341   241 VTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFvalglGAGAGNGSV 320
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1020085945 312 FKLVPMYFSEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITVW 375
Cdd:cd17341   321 FRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLVWL 384
 
Name Accession Description Interval E-value
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
8-375 5.12e-90

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 276.44  E-value: 5.12e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945   8 LSLQTSNLVIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFY 87
Cdd:cd17341     1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  88 ISVA-NSMMDLIIGGLFVGIGGAVFSVGVTSLPKYFPKE-SHGFVNGIYGVGNAGTAITSFLAPVIA-------TSVGWR 158
Cdd:cd17341    81 LALAvSSYWGLLVLGFLLGFAGANFASGQPWASFWFPKEkIGGAAGGIAGAGNMGVAVSQLLAPLIAgaivfdgGFVGWR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 159 TTVQCYLVLLAAFALMNFLLGDR--KEKKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDK 236
Cdd:cd17341   161 NAFFVPGILLAIAAVLVLLFGDDlpTGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 237 VDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAF-----CAGIGNGTI 311
Cdd:cd17341   241 VTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFvalglGAGAGNGSV 320
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1020085945 312 FKLVPMYFSEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITVW 375
Cdd:cd17341   321 FRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLVWL 384
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
7-381 1.63e-83

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 259.81  E-value: 1.63e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945   7 QLSLQTSNLVIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVF 86
Cdd:COG2223     6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  87 YISVANSMMDLIIGGLFVGIG-GAVFSVGVTSLPKYFPKESHGFVNGIY-GVGNAGTAITSFLAPVIATSVGWRTTVQCY 164
Cdd:COG2223    86 LLALAVSYWLLLLLGLLLGIGgGGSFAVGIALVSKWFPPDRRGLALGLAaGGGNLGAAVAAFLAPLLIAAFGWRNAFLIL 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 165 LVLLAAFALMNFLLGDRKEKKVNTP---LMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGM 241
Cdd:COG2223   166 GILLLVVAVLAWLFLRDPPAGAAAAakaSLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGL 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 242 RTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMP-SMNVYTFGCLLVAFCAGIGNGTIFKLVPMYF- 319
Cdd:COG2223   246 LAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFp 325
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1020085945 320 SEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITVWMYSQEK 381
Cdd:COG2223   326 TKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPR 387
2A0108 TIGR00886
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
17-338 3.39e-50

nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]


Pssm-ID: 273322 [Multi-domain]  Cd Length: 354  Bit Score: 172.49  E-value: 3.39e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  17 IGFMVWVILSSLMPY-IKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVAN-SM 94
Cdd:TIGR00886  12 LSFLVWFAFSPLAVFlIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVqSY 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  95 MDLIIGGLFVGIGGAVFSVGVTSLPKYFPKESHGFVNGIY-GVGNAGTAITSFLAPVIA------------TSVGWRTTV 161
Cdd:TIGR00886  92 SVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTALGLAaGWGNMGGGVAQFVMPPIIgslifgggqpahLAWGWAFVI 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 162 QCYLVLLAAFALMNFLLGDR-KEKKVNTPLM-EQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDA 239
Cdd:TIGR00886 172 VPAGILLLPALLIFFVGADTpPGKPATGKLSfKEALKVFGNRHTWILALLYSVTFGSFLGVSSIFAMLFKDQFGLSKVQA 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 240 GMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLS--GIILSFMPSMNVYTFGCLLVAFC--AGIGNGTIFKLV 315
Cdd:TIGR00886 252 GAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGafLVVLGLVSDGSLAAFIVLFVALFffAGAGNGSTFALV 331
                         330       340
                  ....*....|....*....|...
gi 1020085945 316 PMYFSEQAGIVNGLVSALGGLGG 338
Cdd:TIGR00886 332 PHIFRRATGAVSGLIGAIGNLGG 354
MFS_1 pfam07690
Major Facilitator Superfamily;
13-342 4.58e-24

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 101.73  E-value: 4.58e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  13 SNLVIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVAN 92
Cdd:pfam07690   4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  93 SMMDLIIGGLFVGIG-GAVFSVGVTSLPKYFPKESHGFVNGIYGVG-NAGTAITSFLAPVIATSVGWRTTVQCYLVLLAA 170
Cdd:pfam07690  84 SLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGfGLGAALGPLLGGLLASLFGWRAAFLILAILSLL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 171 FALMNFLLGDRKEKKVNTP-------LMEQIKGVYKNEKLWFLCIFyFLTFGSFVAFTVYLPnFLVSHFGLDKVDAGMRT 243
Cdd:pfam07690 164 AAVLLLLPRPPPESKRPKPaeearlsLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLP-LYQEVLGLSALLAGLLL 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 244 AGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMP---SMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFS 320
Cdd:pfam07690 242 GLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSltlSSLWLLLALLLLGFGFGLVFPALNALVSDLAP 321
                         330       340
                  ....*....|....*....|...
gi 1020085945 321 -EQAGIVNGLVSALGGLGGFFPP 342
Cdd:pfam07690 322 kEERGTASGLYNTAGSLGGALGP 344
PRK15034 PRK15034
nitrate/nitrite transport protein NarU; Provisional
8-381 1.58e-19

nitrate/nitrite transport protein NarU; Provisional


Pssm-ID: 184994 [Multi-domain]  Cd Length: 462  Bit Score: 89.94  E-value: 1.58e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945   8 LSLQTSNLVIGFMVWVILSSLMPYI-KADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVF 86
Cdd:PRK15034   36 LWISVSCLLLAFCVWMLFSAVTVNLnKIGFNFTTDQLFLLTALPSVSGALLRVPYSFMVPIFGGRRWTVFSTAILIIPCV 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  87 YISVA-----NSMMDLIIGGLFVGIGGAVFSVGVTSLPKYFPKESHGFVNGIY-GVGNAGTAITSFLAPVIA-------- 152
Cdd:PRK15034  116 WLGIAvqnpnTPFGIFIVIALLCGFAGANFASSMGNISFFFPKAKQGSALGINgGLGNLGVSVMQLVAPLVIfvpvfafl 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 153 ---------------TSVGWRTTVQCYLVLLAAFALMNFLLGDRKEKKVNTPLMEQIkgvykneKLWFLCIFYFLTFGSF 217
Cdd:PRK15034  196 gvngvpqadgsvmslANAAWIWVPLLAIATIAAWSGMNDIASSRASIADQLPVLQRL-------HLWLLSLLYLATFGSF 268
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 218 VAFTVYLPNFLVSHFGldkvDAGMRTAGFI--VLATIMRPIGGWLGDKFNPFKILIFVFIGLTL-SGIILSFMPSMNVYT 294
Cdd:PRK15034  269 IGFSAGFAMLAKTQFP----DVNILRLAFFgpFIGAIARSVGGAISDKFGGVRVTLINFIFMAIfSALLFLTLPGTGSGN 344
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 295 FGCLLVAF-----CAGIGNGTIFKLVPMYF--------------SEQA--------GIVNGLVSALGGLGGFFPPLILTL 347
Cdd:PRK15034  345 FIAFYAVFmglflTAGLGSGSTFQMIAVIFrqitiyrvkmkggsDEQAqreavtetAAALGFISAIGAVGGFFIPQAFGM 424
                         410       420       430
                  ....*....|....*....|....*....|....
gi 1020085945 348 LFQLTGHYAIGFMALSEVALACLIITVWMYSQEK 381
Cdd:PRK15034  425 SLNMTGSPVGAMKVFLIFYIVCVLLTWLVYGRRK 458
 
Name Accession Description Interval E-value
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
8-375 5.12e-90

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 276.44  E-value: 5.12e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945   8 LSLQTSNLVIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFY 87
Cdd:cd17341     1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  88 ISVA-NSMMDLIIGGLFVGIGGAVFSVGVTSLPKYFPKE-SHGFVNGIYGVGNAGTAITSFLAPVIA-------TSVGWR 158
Cdd:cd17341    81 LALAvSSYWGLLVLGFLLGFAGANFASGQPWASFWFPKEkIGGAAGGIAGAGNMGVAVSQLLAPLIAgaivfdgGFVGWR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 159 TTVQCYLVLLAAFALMNFLLGDR--KEKKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDK 236
Cdd:cd17341   161 NAFFVPGILLAIAAVLVLLFGDDlpTGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 237 VDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAF-----CAGIGNGTI 311
Cdd:cd17341   241 VTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFvalglGAGAGNGSV 320
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1020085945 312 FKLVPMYFSEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITVW 375
Cdd:cd17341   321 FRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLVWL 384
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
7-381 1.63e-83

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 259.81  E-value: 1.63e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945   7 QLSLQTSNLVIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVF 86
Cdd:COG2223     6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  87 YISVANSMMDLIIGGLFVGIG-GAVFSVGVTSLPKYFPKESHGFVNGIY-GVGNAGTAITSFLAPVIATSVGWRTTVQCY 164
Cdd:COG2223    86 LLALAVSYWLLLLLGLLLGIGgGGSFAVGIALVSKWFPPDRRGLALGLAaGGGNLGAAVAAFLAPLLIAAFGWRNAFLIL 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 165 LVLLAAFALMNFLLGDRKEKKVNTP---LMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGM 241
Cdd:COG2223   166 GILLLVVAVLAWLFLRDPPAGAAAAakaSLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGL 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 242 RTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMP-SMNVYTFGCLLVAFCAGIGNGTIFKLVPMYF- 319
Cdd:COG2223   246 LAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFp 325
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1020085945 320 SEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITVWMYSQEK 381
Cdd:COG2223   326 TKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPR 387
2A0108 TIGR00886
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
17-338 3.39e-50

nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]


Pssm-ID: 273322 [Multi-domain]  Cd Length: 354  Bit Score: 172.49  E-value: 3.39e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  17 IGFMVWVILSSLMPY-IKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVAN-SM 94
Cdd:TIGR00886  12 LSFLVWFAFSPLAVFlIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVqSY 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  95 MDLIIGGLFVGIGGAVFSVGVTSLPKYFPKESHGFVNGIY-GVGNAGTAITSFLAPVIA------------TSVGWRTTV 161
Cdd:TIGR00886  92 SVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTALGLAaGWGNMGGGVAQFVMPPIIgslifgggqpahLAWGWAFVI 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 162 QCYLVLLAAFALMNFLLGDR-KEKKVNTPLM-EQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDA 239
Cdd:TIGR00886 172 VPAGILLLPALLIFFVGADTpPGKPATGKLSfKEALKVFGNRHTWILALLYSVTFGSFLGVSSIFAMLFKDQFGLSKVQA 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 240 GMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLS--GIILSFMPSMNVYTFGCLLVAFC--AGIGNGTIFKLV 315
Cdd:TIGR00886 252 GAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGafLVVLGLVSDGSLAAFIVLFVALFffAGAGNGSTFALV 331
                         330       340
                  ....*....|....*....|...
gi 1020085945 316 PMYFSEQAGIVNGLVSALGGLGG 338
Cdd:TIGR00886 332 PHIFRRATGAVSGLIGAIGNLGG 354
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
20-376 2.59e-36

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 136.54  E-value: 2.59e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  20 MVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLII 99
Cdd:COG2807    32 PAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLA 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 100 GGLFVGIGGAVFSVGVTSLPK-YFPKEShGFVNGIYGVG-NAGTAITSFLAPVIATSVGWRTTVQCYLVL-LAAFALMNF 176
Cdd:COG2807   112 GTALIGAGIAVGNVLLPGLIKrWFPDRV-GLMTGLYTAAmGLGAALAAGLTVPLAAALGWRGALAVWALLaLLALLLWLP 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 177 LLGDRKEKKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHfGLDKVDAGMRTAGFIVLATIMRPI 256
Cdd:COG2807   191 LLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLL 269
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 257 GGWLGDKFNPFKILIFVFIGLTLSGII-LSFMPSMNVYtfgclLVAFCAGIGNGTIFKLVPMYFS------EQAGIVNGL 329
Cdd:COG2807   270 VPLLADRLGDRRPLLLLLGLLGLAGLLgLLLAPGSLPW-----LWAVLLGLGQGGLFPLALTLIGlrartpAEAAALSGM 344
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1020085945 330 VSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITVWM 376
Cdd:COG2807   345 AQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
16-376 1.22e-31

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 123.06  E-value: 1.22e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  16 VIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMM 95
Cdd:COG2271    20 FLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFW 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  96 DLIIGGLFVGIG-GAVFSVGVTSLPKYFPKESHGFVNGIYGVG-NAGTAITSFLAPVIATSVGWRTTVQCYLVLLAAFAL 173
Cdd:COG2271   100 QLLLLRFLLGLGeAGFFPAALKLIAEWFPPKERGRALGIFNAGgPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLAL 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 174 MNFllgdrkekkvntplmeqikgvykneklWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIM 253
Cdd:COG2271   180 LRF---------------------------WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVG 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 254 RPIGGWLGDKFNPFK--ILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFS-EQAGIVNGLV 330
Cdd:COG2271   233 SLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLV 312
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1020085945 331 SALGGLGGFFPPLILTLLFQLTGhYAIGFMALSEVALACLIITVWM 376
Cdd:COG2271   313 NTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLL 357
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
16-338 2.32e-30

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 119.31  E-value: 2.32e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  16 VIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMM 95
Cdd:COG2814    20 FLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLW 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  96 DLIIGGLFVGIGGAVFSVGVTSL-PKYFPKESHGFVNGIYGVG-NAGTAITSFLAPVIATSVGWRTTVQCYLVLLAAFAL 173
Cdd:COG2814   100 LLLAARFLQGLGAGALFPAALALiADLVPPERRGRALGLLGAGlGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALL 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 174 MNFLLGDRKEKKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIM 253
Cdd:COG2814   180 LLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLG 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 254 RPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFS-EQAGIVNGLVSA 332
Cdd:COG2814   260 ALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPpEARGRASGLYNS 339

                  ....*.
gi 1020085945 333 LGGLGG 338
Cdd:COG2814   340 AFFLGG 345
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
16-374 5.97e-26

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 107.27  E-value: 5.97e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  16 VIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMM 95
Cdd:cd17319    13 VINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLT 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  96 DLIIGGLFVGIG-GAVFSVGVTSLPKYFPKESHGFVNGIYGVGNA-GTAITSFLAPVIATSVGWRttvqcylVLLAAFAL 173
Cdd:cd17319    93 SLYVLRFLLGVAeAGFFPGAIKALAEWFPARERGRATGLFNSGAPlGAAIGPPLSGWLLLLFGWR-------WAFIIEGL 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 174 MNFLLGdrkekkvntplmeqIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIM 253
Cdd:cd17319   166 LGLLLA--------------VLWWFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIG 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 254 RPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMP-SMNVY-TFGCLLVA-FCAGIGNGTIFKLVPMYFS-EQAGIVNGL 329
Cdd:cd17319   232 MILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYlTTSPVvAVILLSLAgFGIGAASPVFWSLPADLLPgEAAATAGGL 311
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1020085945 330 VSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITV 374
Cdd:cd17319   312 INSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVL 356
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
15-375 2.07e-24

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 103.40  E-value: 2.07e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  15 LVIGFMVWvILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSM 94
Cdd:COG0738    18 FLWGFATA-LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  95 MDLIIGGLFVGIGGAVFSVGVTSL-PKYFPKESHGFVNGIYGVGNAGTAITSFLAPVIATSVGWRTTVQCYLVLLAAFAL 173
Cdd:COG0738    97 PLLLLALFLLGLGLGLLDVAANPYvAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLL 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 174 MNFLL------GDRKEKKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFI 247
Cdd:COG0738   177 LALLFlrsklpEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFW 256
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 248 VLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFSEQAGIVN 327
Cdd:COG0738   257 GGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAV 336
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1020085945 328 GLVSALGGLGGFFPPLILTLLFQLTG-HYAIGFMALSEVALACLIITVW 375
Cdd:COG0738   337 SAVLIMGIVGGAIGPPLIGFLADAFGlRAAFLVPLVCYLLILLLALALK 385
MFS_1 pfam07690
Major Facilitator Superfamily;
13-342 4.58e-24

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 101.73  E-value: 4.58e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  13 SNLVIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVAN 92
Cdd:pfam07690   4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  93 SMMDLIIGGLFVGIG-GAVFSVGVTSLPKYFPKESHGFVNGIYGVG-NAGTAITSFLAPVIATSVGWRTTVQCYLVLLAA 170
Cdd:pfam07690  84 SLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGfGLGAALGPLLGGLLASLFGWRAAFLILAILSLL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 171 FALMNFLLGDRKEKKVNTP-------LMEQIKGVYKNEKLWFLCIFyFLTFGSFVAFTVYLPnFLVSHFGLDKVDAGMRT 243
Cdd:pfam07690 164 AAVLLLLPRPPPESKRPKPaeearlsLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLP-LYQEVLGLSALLAGLLL 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 244 AGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMP---SMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFS 320
Cdd:pfam07690 242 GLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSltlSSLWLLLALLLLGFGFGLVFPALNALVSDLAP 321
                         330       340
                  ....*....|....*....|...
gi 1020085945 321 -EQAGIVNGLVSALGGLGGFFPP 342
Cdd:pfam07690 322 kEERGTASGLYNTAGSLGGALGP 344
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
39-373 4.39e-21

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 93.38  E-value: 4.39e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  39 TAGQISMVTAVPVILGSVlriPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFVGI-GGAVFSVGVTS 117
Cdd:cd17324    35 QAGLLVSAYALGYALGAL---LLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLaHGGFWAIAAAY 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 118 LPKYFPKESHGFVNGIYGVGNA-GTAITSFLAPVIATSVGWRTTVQCY--LVLLAAFALMNFLLGDRKEKKVNTPLMEQI 194
Cdd:cd17324   112 AADLVPPEKRGRAIGLVFSGLTlGLVLGRPLGGLLGQLLGWRAAFLAIavLALLAALLLWRLLPSLPPKKPGSLGLLSSL 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 195 KGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFnPFKILIFVF 274
Cdd:cd17324   192 LLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRG-GRRALLIAL 270
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 275 IGLTLSGIILSFM-PSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFSEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTG 353
Cdd:cd17324   271 LLLAAALLLLTLLgPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGG 350
                         330       340
                  ....*....|....*....|
gi 1020085945 354 HYAIGFMALSEVALACLIIT 373
Cdd:cd17324   351 WAGVGWVGAALLLLALLLAL 370
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
19-374 5.77e-21

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 93.26  E-value: 5.77e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  19 FMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLI 98
Cdd:cd06174     9 GLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  99 IGGLFVGIGGAVFSVGVTSL-PKYFPKESHGFVNGIY-GVGNAGTAITSFLAPVIATSVGWRTTVQCY---LVLLAAFAL 173
Cdd:cd06174    89 LGRFLLGLGSGLIDPAVLALiADLFPERERGRALGLLqAFGSVGGILGPLLGGILASSLGFGWRAVFLiaaALALLAAIL 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 174 MNFLLGDRKEKKVN-------TPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGF 246
Cdd:cd06174   169 LLLVVPDPPESARAkneeassKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLF 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 247 IVLATIMRPIGGWLGDK-FNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFS-EQAG 324
Cdd:cd06174   249 GLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPpEIRG 328
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1020085945 325 IVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITV 374
Cdd:cd06174   329 TAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
15-377 9.41e-21

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 92.64  E-value: 9.41e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  15 LVIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSM 94
Cdd:cd17325     5 LFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  95 MDLIIGGLFVGIGGAVFSVGVTSL-PKYFPKESHGFVNGIYGVGN-AGTAITSFLAPVIATSVGWRTT-VQCYLVLLAAF 171
Cdd:cd17325    85 WQLLLARFLQGLASAAVWPAAMALiADIAPPEERGRAMGIFSSAIgLGFLIGPLLGGLLADALGYRAPfLVCAALALLAL 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 172 ALMNFLLGDRKEKKVNTPLMEQ-----IKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGF 246
Cdd:cd17325   165 VLALLLLPEPRPPPNKRAVSAArlrsgLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQ 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 247 IVLATIMRPIGGWLGDKFNPFKILIfvfIGLTLSGIILSFMPSMNVYTFgCLLVAFCAGIGNGTIFKLVPMYFSEQA--- 323
Cdd:cd17325   245 GLASALSQPPAGKLSDRIGRKPLIL---IGLLLSAVALLLLPLATSFWL-LLLLLALLGLGLGLVFPATLALLADIVppe 320
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1020085945 324 --GIVNGLVSALGGLGGFFPPLILTLLFQLTGhYAIGFMALSEVALACLIITVWMY 377
Cdd:cd17325   321 grGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVLFLLLR 375
PRK15034 PRK15034
nitrate/nitrite transport protein NarU; Provisional
8-381 1.58e-19

nitrate/nitrite transport protein NarU; Provisional


Pssm-ID: 184994 [Multi-domain]  Cd Length: 462  Bit Score: 89.94  E-value: 1.58e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945   8 LSLQTSNLVIGFMVWVILSSLMPYI-KADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVF 86
Cdd:PRK15034   36 LWISVSCLLLAFCVWMLFSAVTVNLnKIGFNFTTDQLFLLTALPSVSGALLRVPYSFMVPIFGGRRWTVFSTAILIIPCV 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  87 YISVA-----NSMMDLIIGGLFVGIGGAVFSVGVTSLPKYFPKESHGFVNGIY-GVGNAGTAITSFLAPVIA-------- 152
Cdd:PRK15034  116 WLGIAvqnpnTPFGIFIVIALLCGFAGANFASSMGNISFFFPKAKQGSALGINgGLGNLGVSVMQLVAPLVIfvpvfafl 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 153 ---------------TSVGWRTTVQCYLVLLAAFALMNFLLGDRKEKKVNTPLMEQIkgvykneKLWFLCIFYFLTFGSF 217
Cdd:PRK15034  196 gvngvpqadgsvmslANAAWIWVPLLAIATIAAWSGMNDIASSRASIADQLPVLQRL-------HLWLLSLLYLATFGSF 268
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 218 VAFTVYLPNFLVSHFGldkvDAGMRTAGFI--VLATIMRPIGGWLGDKFNPFKILIFVFIGLTL-SGIILSFMPSMNVYT 294
Cdd:PRK15034  269 IGFSAGFAMLAKTQFP----DVNILRLAFFgpFIGAIARSVGGAISDKFGGVRVTLINFIFMAIfSALLFLTLPGTGSGN 344
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 295 FGCLLVAF-----CAGIGNGTIFKLVPMYF--------------SEQA--------GIVNGLVSALGGLGGFFPPLILTL 347
Cdd:PRK15034  345 FIAFYAVFmglflTAGLGSGSTFQMIAVIFrqitiyrvkmkggsDEQAqreavtetAAALGFISAIGAVGGFFIPQAFGM 424
                         410       420       430
                  ....*....|....*....|....*....|....
gi 1020085945 348 LFQLTGHYAIGFMALSEVALACLIITVWMYSQEK 381
Cdd:PRK15034  425 SLNMTGSPVGAMKVFLIFYIVCVLLTWLVYGRRK 458
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
28-373 6.12e-18

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 84.60  E-value: 6.12e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  28 LMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFVGIG 107
Cdd:cd17475    18 LAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAG 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 108 GAVF-SVGVTSLPKYFPKESHGFVNGIYGVG-NAGTAITSFLAPVIATSVGWRTTVQCYLVLLAAFALMNFLL------G 179
Cdd:cd17475    98 YGSVqPGGGRAIMRWFPPRERGLAMGIRQTGvPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFyreppaA 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 180 DRKEKKVNTPLMEqIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGW 259
Cdd:cd17475   178 SAATESASTLLRS-LKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGR 256
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 260 LGDKFNP---FKILIFVFIGLTLSGIILSFMPSmnvYTFGCLLVAFCAGIG------NGTIFKLVP-MYFSEQAGIVNGL 329
Cdd:cd17475   257 VSDRVFGgrrRPVLVITAAIAAAALLVLSLLSP---GTPLWLLVLLLILLGlfaigwNGLYLTLVAeSAGPEQAGTALGL 333
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1020085945 330 VSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIIT 373
Cdd:cd17475   334 ANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLL 377
MFS_NIMT_CynX_like cd17339
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ...
23-376 1.10e-17

2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340897 [Multi-domain]  Cd Length: 374  Bit Score: 83.78  E-value: 1.10e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  23 VILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFyISVANSMMDLIIGGL 102
Cdd:cd17339    16 TSVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGIL-LRSLGGIALLFLGTA 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 103 FVGIGGAVFSVGVTSLPK-YFPKEShGFVNGIYGVG-NAGTAITSFLAPVIATSV--GWRTTVQCyLVLLAAFALMNFLL 178
Cdd:cd17339    95 LAGAGIAVGNVLLPSLIKrDFPRRV-GLMTGLYTTSmNLGAALASGLSVPLAQALggGWRGALAI-WALPALLALLIWLP 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 179 GDRKEKKVNTPLMEQIKG-VYKNEKLWFLCIFYFLTfgSFVAFTV--YLPNFLVSHfGLDKVDAGMRTAGFIVLATIMRP 255
Cdd:cd17339   173 QLRRRKRAAAAAAPLTKIsVWRSPLAWQVTLFMGLQ--SLLFYTLmaWLPTILIDA-GLSAATAGWLLSLFQLVGIPASL 249
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 256 IGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVafcaGIGNGTIFKLVPMYFS------EQAGIVNGL 329
Cdd:cd17339   250 LVPILATRLKNQRPIVVLLAVLFIIGVLGLLFAPTALALLWAVLL----GLGGGAAFSLALTLISlrssdpAEAAALSGM 325
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1020085945 330 VSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITVWM 376
Cdd:cd17339   326 AQSVGYLLAALGPLLFGVLHDLTGSWTAPLVLLLALTVLQLVAGLGA 372
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
24-312 1.36e-17

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 83.39  E-value: 1.36e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  24 ILSSLMPYIKADIPLTAGQISMVTAVpVILGSVLRIPI-GYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGL 102
Cdd:cd17503    14 IVNVALPTIMGDLGASLDTVQWVITS-YLLALAIMIPLsGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRI 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 103 FVGIGGAV-FSVGVTSLPKYFPKESHGFVNGIYGVGNA-GTAITSFLAPVIATSVGWRTtvqCYLVLLAaFALMNFLLGd 180
Cdd:cd17503    93 LQGFGGGVlIPLAQTILLRIYPPEKRGAAMGLVGLVILlAPAIGPTLGGWLTDNLSWRW---IFYINLP-IGILALLLA- 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 181 rkekkvntPLMEQikGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWL 260
Cdd:cd17503   168 --------PLLDL--RLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRL 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1020085945 261 GDKFNPFKILIFVFIGLTLSGIILSFM-PSMNVYTFGCLLvaFCAGIGNGTIF 312
Cdd:cd17503   238 LDKFGPRLLLLAGLLLLALGTLLLAFLtPDTSLWLIILPL--FIRGLGMGLVF 288
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
16-375 4.91e-17

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 81.49  E-value: 4.91e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  16 VIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMM 95
Cdd:cd17489     6 FFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  96 DLIIGGLFVGIG-GAVFSVGVTSLPKYFPKESHGFVNGIYGVGNA-GTAITSFLAPVIATSVGWRTTVQCYLVLLAAFAL 173
Cdd:cd17489    86 LLLVLRLIHGIGwGAFTTAAATLVADIIPPSRRGEGIGYYGLATTlAMALGPALGLFLYQHLGFAVLFIVAAVLALLALL 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 174 MNFLLGDRKEKKVNTPLMEQI-KGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGldkVDAGMRTAGFIVLATI 252
Cdd:cd17489   166 LVFLVKDPPPVAAEEAEAGTRaFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGI---SNAGLFFTVYAIALLL 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 253 MRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYtfgcLLVAFCAGIGNGTIF--------KLVPmyfSEQAG 324
Cdd:cd17489   243 SRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWML----LLAAVLYGLGFGLLFpalqalavDLVP---PHRRG 315
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1020085945 325 IVNGLVSALGGLGGFFPPLILTLLFQLTGhYAIGFMALSEVALACLIITVW 375
Cdd:cd17489   316 AANGTFFIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLALVLYIF 365
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
19-374 2.32e-15

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 76.49  E-value: 2.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  19 FMVWVILSSLMPYIKADIP--LTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMD 96
Cdd:cd17316    12 AYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPIL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  97 LIIGGLFVGIG-GAVFSVGVTSLPKYFPKESHGFVNGIYGVGNA-----GTAITSFLAPVIATSVGWRTtvqcYLVLLAA 170
Cdd:cd17316    92 LLVLRFLQGIGiGGEYPGASTYVAEFAPSKRRGFALGLLQSGWAlgallAALVASLLIPLLSGDWGWRI----LFLIGAL 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 171 FALMNFLLGDRkekkvntplmeqikgvyknekLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLA 250
Cdd:cd17316   168 PALLALLLRRR---------------------TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGA 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 251 TIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYT--FGCLLVAFCAGIGNGTIFKLVPMYF-SEQAGIVN 327
Cdd:cd17316   227 LVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLllLLLFILSFFVGGVWGALYAYLAELFpTEVRATGV 306
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1020085945 328 GLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITV 374
Cdd:cd17316   307 GLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
16-376 1.06e-14

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 75.00  E-value: 1.06e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  16 VIGFMVWVILSSLMPYIK---ADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVAN 92
Cdd:cd17355    10 LILILSWGIRYYFGVFIIpiiAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALAT 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  93 SMMDLIIGGLFVGIGGAVFSVGV--TSLPKYFPKESHGFVngiYGVGNAGTAITSFL-APVIATSV---GWRTTVQCY-- 164
Cdd:cd17355    90 SLWQLYLLWGLLGGGGAGTLAAVafATVAAWWFERRRGLA---LGILTAGGGLGSLVfLPLGAALIeafGWRTALLVLal 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 165 LVLLAAFALMNFLLGDRKEKKV-------NTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHfGLDKV 237
Cdd:cd17355   167 LALLVLVPVLLLLRRRPADLALrayddasPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADR-GISPA 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 238 DAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSF--MPSMNVYTFGCLLVAFCAGIGNGTIFKLV 315
Cdd:cd17355   246 AAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLlpFPPLALLLFAALFGLGWGATVPLTAALAA 325
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1020085945 316 PMYFSEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFmALSEVALACLIITVWM 376
Cdd:cd17355   326 RYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAW-ALAVALGLIAALLVLP 385
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
24-344 1.08e-14

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 74.51  E-value: 1.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  24 ILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLF 103
Cdd:cd17478    14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 104 VGIGGAVFSVGVTSLPKYFPKESHGFVNGIYGV-GNAGTAITSFLA-PVIATSVGWRTTVQCYLVLLAAFALMNFLLGDR 181
Cdd:cd17478    94 AGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVgGNLGFALGPLIAaALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 182 KEKKVNTPLMEQIKGVYKNE--KLWFLCIFYFLTFGSFVAFTVYLPNFLVSHfGLDKVDAGMRTAGFIVLATIMRPIGGW 259
Cdd:cd17478   174 KPEAKKAAAKSSARSTLKGVwrALLLLLIIVFLRSWVLSSLTTFLPFYLVQR-GYSLVFAGLLLSLFLFAGAIGTLIGGP 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 260 LGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYtfgclLVAFCAGIGNGTIFKLVPMY----FSEQAGIVNGLVSALG- 334
Cdd:cd17478   253 LSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSY-----ILLVLAGFLLFASFPVTVVLaqelLPGNVGLASGLMMGLSf 327
                         330
                  ....*....|
gi 1020085945 335 GLGGFFPPLI 344
Cdd:cd17478   328 GLGGIGAPVL 337
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
25-353 1.12e-14

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 74.72  E-value: 1.12e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  25 LSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFV 104
Cdd:TIGR00881  14 FALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALN 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 105 GI-GGAVFSVGVTSLPKYFPKESHGFVNGIYGVGN--AGTAITSFLAPVIATSVGWRTTVQCYLVLLAAFALMNFLLG-- 179
Cdd:TIGR00881  94 GIfQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHnvGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLrd 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 180 -------------------DRKEKKVNTPLMEQIKGVY--KNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVD 238
Cdd:TIGR00881 174 spqscglppaeempneepdGDAEKKEEELTKKQIFLQYvlLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEK 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 239 AGMRTAGFIVLATIMRPIGGWLGDKF---NPFKILIFVFIGLTLSGIILSFMPSMNVYTFG-CLLVAFCAGIGNGTIFKL 314
Cdd:TIGR00881 254 ASWAFTLYELGGLVGTLLAGWLSDKLfngRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLiCLFALGFLVYGPQMLIGV 333
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1020085945 315 VPM--YFSEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTG 353
Cdd:TIGR00881 334 IASelAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
20-353 2.43e-14

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 74.17  E-value: 2.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  20 MVWVILSSLMPYIKADIP-LTAGQISMVTAVPVILGSVLRIPIGYWT----NRFGARKLFF--------ISFILLlFPVF 86
Cdd:COG2211    24 LAFGLLSAYLLYFYTDVLgLSAALVGLILLVARLWDAITDPLIGALSdrtrTRWGRRRPWIligaiplaLSFVLL-FTAP 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  87 YISVANSMMDLIIGGLFVGIGGAVFSVGVTSLP--KYFPKESHGFVNGI-YGVGNAGTAITSFLAPVIATSV------GW 157
Cdd:COG2211   103 DLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGaeLTPDYEERTRLSSWrFAFAGLGGLLASVLPPPLVAAFggdaalGY 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 158 RTTVQCYLVLLAAFALMNFLLGDRK--EKKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLD 235
Cdd:COG2211   183 RLTALIFAVLGLLAFLLTFFGTKERpvPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLS 262
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 236 KVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFgcLLVAFCAGIGNGTIFKLV 315
Cdd:COG2211   263 AALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLL--LVLAALAGIGLGAILVLP 340
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1020085945 316 PMYFSE------------QAGIVNGLVSALGGLGGFFPPLILTLLFQLTG 353
Cdd:COG2211   341 WAMLADvvdydewktgrrREGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
32-376 1.19e-13

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 71.45  E-value: 1.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  32 IKADIPLTAGQISMVTAVP---VILGSVLripIGYWTNRFGARKLFFISfiLLLFPVFYIS--VANSMMDLIIGGLFVGI 106
Cdd:cd17473    26 AQHFVPNSELLVPLLLTLPalfIALFAPL---AGWLADRFGRKRLLIAG--LLLYGIGGVAglFLDSLYALLASRALLGI 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 107 GGAVFSVGVTSL-PKYFPKESHGFVNGIYGVGNAGTAITSFLAPVIATSVGWRTTVQCYLVLLAAFALMNFLLGDRKEKK 185
Cdd:cd17473   101 GVAGIMTLATALiGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLALPVLILVLLFLPEPARKS 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 186 VNTPLM-EQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKF 264
Cdd:cd17473   181 KSAASPgAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRL 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 265 NPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGI----GNGTIFKLVPmyfSEQAGIVNGLVSALGGLGGFF 340
Cdd:cd17473   261 GKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLllptLNSWAMSLVP---PELRGRAMGIVTSAFFLGQFL 337
                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1020085945 341 PPLILTLLFQLTGHYAIGFMALSEVALACLIITVWM 376
Cdd:cd17473   338 SPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
16-373 3.26e-13

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 70.29  E-value: 3.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  16 VIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMM 95
Cdd:cd17474     9 LLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  96 DLIIGGLFVGIGGAVF-SVGVTSLPKYFPKESHGFVNGIYGVGN-AGTAITSFLAPVIAtSVGWRTTVQCYLVL-LAAFA 172
Cdd:cd17474    89 LLLAGRALQGIGAAGLgPLALTLIGDLFEGGERAKAMGLYEAALgLGIAVGPLLGGLLA-AISWRYPFFLLAALiPVAFL 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 173 LMNFLLGDRKEKKVNTPLMEQIKGVYKNEKLWFLCIFY--FLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLA 250
Cdd:cd17474   168 AILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVsaFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLL 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 251 TIMRPIGG-WLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFSEQA-GIVNG 328
Cdd:cd17474   248 ALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEErGTASS 327
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1020085945 329 LVSALGGLGGFFPPLILTLLFQLTGHYAIgFMALSEVALACLIIT 373
Cdd:cd17474   328 LYNFVRFLGQAVGPLLFGLLLEIFGLSAP-FLVGAAIALAAAVLL 371
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
15-377 9.20e-13

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 68.79  E-value: 9.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  15 LVIGFMVWVILSSLMPYIKADIPLTAGQISMVTavpVILGS------VLRIPIGYWTNRFGARKLF-FISFILLLFPVFY 87
Cdd:cd17490     2 LIIVFLFWFSQYVYVPFLSPYAESLGASLSMIG---IILGAygisqmLLRIPLGILSDRIGKRKLFiIIGLLFTVLASLI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  88 ISVANSMMDLIIGGLFVGIGGAVFSVGVTSLPKYFPKESHGFVNG-IYGVGNAGTAITSFLAPVIATSVGWRttVQCYLV 166
Cdd:cd17490    79 MILFPSPWGLLIARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGlINLVNNLGQLIAFLIGGLIAEHFGMR--APFLLA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 167 LLA---AFALMNFLLGDRKEKKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRT 243
Cdd:cd17490   157 ALAgvlGFILSLFIKEERREKKPVLTELKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLS 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 244 AGFIVLATIMRPIGGWL-GDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYtfgcLLVAFCAGIGNGTIFKLVpMYFS-- 320
Cdd:cd17490   237 IIYLLPNALASLLSGTLfYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLL----YLLQALNGFGTGILFPLL-MSLSie 311
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1020085945 321 ----EQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGhYAIGFMALSEVALACLIITVWMY 377
Cdd:cd17490   312 gvpaEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFG-LQTGFFVIGVIALLAAILSLAYY 371
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
26-372 2.43e-12

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 67.64  E-value: 2.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  26 SSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIG-GLFV 104
Cdd:cd17353    23 SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGyGVLG 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 105 GIG-GAVFSVGVTSLPKYFPkESHGFVNGIY--GVGnAGTAITSFLAPVIATSVGWRTTvqcYLVLLAAFALMNFLLG-- 179
Cdd:cd17353   103 GIGaGIGYITPVSTAVKWFP-DKRGLATGIViaGFG-LGSLIFSPLIAYLINTVGVPTT---FLILGIIFLIIIVIGAfl 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 180 --------------DRKEKKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAG 245
Cdd:cd17353   178 irdppkgwvppgvdPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSI 257
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 246 FIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNV-YTFGCLLVAFCAGIGNGTIFKLVPMYFSE-QA 323
Cdd:cd17353   258 LSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVlFVLGVALIGFCYGGGFALFPALTADFFGTkNA 337
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1020085945 324 GIVNGLVSALGGLGGFFPPLILTLLfqltgHYAIGFMALSEVALACLII 372
Cdd:cd17353   338 GTNYGLLYTAKGVGGLIGPIIAAYV-----LYTGGYNAAFIIAAALSLV 381
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
39-372 5.56e-12

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 66.42  E-value: 5.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  39 TAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIG-GLFVGIG-GAVFSVGVT 116
Cdd:cd17352    36 STSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTyGVLGGLGlGLIYSPAIV 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 117 SLPKYFPKEsHGFVNGIygvGNAGTAITSFLAPVIATS----VGWRTTVQ----CYLVLLAAFALMNFLlgdrkekkvnt 188
Cdd:cd17352   116 IVGQYFEKK-RGLATGI---AVAGSGVGTFVFPPLLRYlldnYGWRGALLilggLCLNLCVCGLLLRLL----------- 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 189 plmeqikgvyKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHfGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKfNPFK 268
Cdd:cd17352   181 ----------KDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSL-GIDESDAAFLLSIIGISDIVGRILLGLLADK-PRIG 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 269 ILIFVFIGLTLSGIILSFMPSMNVYT---FGCLLVAFCAGIGNGTIFKLVPMYFS-EQAGIVNGLVSALGGLGGFFPPLI 344
Cdd:cd17352   249 RLYLYIFTLLILGLSLLAFPLATTYVgliVFSVLFGFCSGSYSSLTPVILADLVGlEKLSNAYGLVLLFQGLAALVGPPI 328
                         330       340
                  ....*....|....*....|....*...
gi 1020085945 345 LTLLFQLTGHYAIGFMALSEVALACLII 372
Cdd:cd17352   329 AGLLRDYTGDYDAAFYFCGACLLLSGVL 356
PLN00028 PLN00028
nitrate transmembrane transporter; Provisional
19-375 6.10e-12

nitrate transmembrane transporter; Provisional


Pssm-ID: 177665 [Multi-domain]  Cd Length: 476  Bit Score: 66.87  E-value: 6.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  19 FMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLI 98
Cdd:PLN00028   49 FVSTFAAAPLLPIIRDNLNLTKSDIGNAGIASVSGSIFSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFI 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  99 IGGLFVGIGGAVFSVGVTSLPKYFPKESHGFVNGIY-GVGNAGTAITSFLAPVI---------ATSVGWRTtvqCYLV-- 166
Cdd:PLN00028  129 AVRFFIGFSLATFVSCQYWMSTMFNGKIVGTANGIAaGWGNLGGGVTQLLMPLVfplikdagaPSFTAWRI---AFFVpg 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 167 -LLAAFALMNFLLGD-------RKEKKVNTP----LMEQIKGVYKNEKLWFLCIFYFLTFGsfVAFTV--YLPNFLVSHF 232
Cdd:PLN00028  206 lLHIIMGILVLTLGQdlpdgnyRELKKSGTMpkdsFSKVLRYGVTNYRTWILALTYGYSFG--VELTMdnIIAEYFYDRF 283
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 233 GLDKVDAGMRTAGFIVLATIMRPIGGWLGDK-FNPFKI---LIFVFIGLTLSG---IILSFMPSMNVYTFGCLLVAFCAG 305
Cdd:PLN00028  284 GLSLETAGAIAASFGLMNLFARPAGGYLSDVaARRFGMrgrLWALWIVQTLGGvfcIWLGRANSLGAAIVVMILFSIFVQ 363
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 306 IGNGTIFKLVPMYFSEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITVW 375
Cdd:PLN00028  364 AACGATFGIVPFVSRRSLGVISGLTGAGGNVGAVLTQLLFFTGSSYSTETGISLMGVMIIACTLPVAFIH 433
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
37-379 6.29e-11

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 63.40  E-value: 6.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  37 PLTAGQISMVTAVPVILGSVlriPIGYWTNRFGARKLFFISFIL-----LLFPVFYISVANSMMDLIIGGLFVGIGGAVF 111
Cdd:cd06173    33 ALLVGLVLAAFFLPFLLFSP---FAGVLADRFDRRRLLILADLLrallaAVLALLALLGSLSLWLLLVLAFLLGIASAFF 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 112 SVGVTS-LPKYFPKESHGFVNGIYGVGN-----AGTAITSFLAPVIATSVGWRTTVQCYLVLLAAFALMNFLLGDRKEKK 185
Cdd:cd06173   110 GPARQAlLPELVPKEQLVRANALNSLATqlariIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGES 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 186 VNTPLMEQIKG---VYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGD 262
Cdd:cd06173   190 SSLLLRDLREGlryLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSK 269
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 263 KFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFSEQ-AGIVNGLVSALGGLGGFFP 341
Cdd:cd06173   270 RRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDElRGRVFSVYNALNSGAMPLG 349
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1020085945 342 PLILTLLFQLTGHYAIGFMAlsevALACLIITVWMYSQ 379
Cdd:cd06173   350 ALLAGLLADALGLSAVFLLA----GALLLLAALLLLLL 383
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
19-349 7.18e-11

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 62.96  E-value: 7.18e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  19 FMVWV---ILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMM 95
Cdd:cd17321     6 FLAALdvtIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  96 DLIIGGLFVGIGGAVFSVGVTSLPK-YFPKESHGFVNGIYGVGNA-GTAITSFLAPVIATSVGWRTTvqcyLVLLAAFAL 173
Cdd:cd17321    86 FLIAARALQGIGAAAIMPASLALIAaTFPGERRGRALGLWGAVVGiGAALGPLLGGLLLELFGWRWI----FLINVPIGL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 174 MNFLLGDRkekkvntplmeqikgvyknekLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIM 253
Cdd:cd17321   162 VALLLART---------------------FSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVA 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 254 RPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFgCLLVAFCAGIGNGTIFKLVPMYFS-----EQAGIVNG 328
Cdd:cd17321   221 APLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWL-LLPGLVLLGLGLGLFATPLTNAALssvpkEKAGAASG 299
                         330       340
                  ....*....|....*....|.
gi 1020085945 329 LVSALGGLGGFFPPLILTLLF 349
Cdd:cd17321   300 ILNTARQLGGALGVALLGALL 320
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
203-376 3.80e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 60.65  E-value: 3.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 203 LWFLCIFYFLTFGSFVAFTVYLPnFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGI 282
Cdd:COG2271    12 LALLFLAYFLNYLDRSNLSVAAP-PLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 283 ILSFMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFS-EQAGIVNGLVSALGGLGGFFPPLILTLLFQLTG-HYAIGFM 360
Cdd:COG2271    91 LFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPpKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGwRAAFLIL 170
                         170
                  ....*....|....*.
gi 1020085945 361 ALseVALACLIITVWM 376
Cdd:COG2271   171 GL--PGLLLALLRFWL 184
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
59-350 9.00e-10

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 59.64  E-value: 9.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  59 IPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFVGIG-GAVFSVGVTSLPKYFPKESHGFVNGIYGVG 137
Cdd:cd17333    49 LLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGaGILDTGANTFVGALFEESSATRLNVLHGFF 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 138 NAGTAITSFLAPVIATSVGWRTT-------VQCYLVLLAAFALMNFLLGDRKEKKVNTPLMEQIKGVYKNEKLWFLCIFY 210
Cdd:cd17333   129 GLGALIGPLIATSLLTSELSWSWayliiglIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALAL 208
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 211 FLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSM 290
Cdd:cd17333   209 FLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTL 288
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 291 NVYTFGCLLVAFCAGIGNGTIFKLVPMYFSEQAGIVNGLVSALGGLGGFFPPLILTLLFQ 350
Cdd:cd17333   289 VVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAE 348
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
23-379 1.16e-09

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 59.14  E-value: 1.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  23 VILSSLMPYIKADIPLTAGQISMVTA---VPVILGSVLripIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLII 99
Cdd:cd17365    16 AVMGFVAPALAQDWGLSPAQLGPVGSaalFGMAIGALL---AGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 100 GGLFVGIG-GAVFSVGVTSLPKYFPKESHGFVNGIYGVG-NAGTAITSFLAPVIATSVGWRTTVqcYLVLLAAFALMNFL 177
Cdd:cd17365    93 LRFLTGLGlGAAMPNAITLVSEYAPARRRSLAVTLMFCGyPLGAALGGFLAAALIPAFGWRSVF--LLGGVPPLILLPLL 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 178 LGDrkekkvntpLMeqikgvykneklwfLCIFYFLTFGSFVAFTVYLPNFLVSHfGLDKVDAGMRTAGFIVLATIMRPIG 257
Cdd:cd17365   171 RGT---------LL--------------LWVTFFMGLLLVYLLNSWLPKLMVEA-GYSLSQALTITLLLNIGGVIGSLLL 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 258 GWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGIG-NGTIFKLVPMYFSEQA-GIVNGLVSALGG 335
Cdd:cd17365   227 GWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGaQVGLYALAARFYPTEVrATGVGWALGVGR 306
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1020085945 336 LGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITVWMYSQ 379
Cdd:cd17365   307 LGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVLLLRLR 350
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
203-376 4.26e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 57.68  E-value: 4.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 203 LWFLCIFYFLTFGSFVAFTVYLPnFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGI 282
Cdd:COG2814    12 LLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 283 ILSFMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFS-EQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGhYAIGFMA 361
Cdd:COG2814    91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WRWVFLV 169
                         170
                  ....*....|....*
gi 1020085945 362 LSEVALACLIITVWM 376
Cdd:COG2814   170 NAVLALLALLLLLRL 184
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
181-375 3.26e-08

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 54.84  E-value: 3.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 181 RKEKKVNTPLMEQIKGVYKNekLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWL 260
Cdd:cd17369   210 EAGQVVRAPLVEVLRRHWRA--LLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWL 287
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 261 GDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFSEQAGIVN-----GLVSALGG 335
Cdd:cd17369   288 SDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVrytgaSLGYQLGA 367
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1020085945 336 -LGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITVW 375
Cdd:cd17369   368 iLGGGFAPLIATALVAATGSWWPVALYLAALAVISLVAALF 408
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
217-315 5.81e-08

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 54.22  E-value: 5.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 217 FVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTL-SGIILSFMPSMN--VY 293
Cdd:cd17367   239 FYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLaTVPLLSALDHTDspYT 318
                          90       100
                  ....*....|....*....|..
gi 1020085945 294 TFGCLLVAFCAGIGNGTIFKLV 315
Cdd:cd17367   319 AFALVLVGLVFLSGYTSINAVV 340
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
25-372 6.23e-08

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 53.82  E-value: 6.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  25 LSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSM----MDLIIG 100
Cdd:cd17312    22 FSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLwffaVLWGLN 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 101 GLFVGIGgavFSVGVTSLPKYFPKESHGFVNGIYGVG-NAGTAITSFLAPVIATSVGWRTTVQCYLVLLAAFALMNFLLg 179
Cdd:cd17312   102 GLFQSMG---WPPCVKLLGNWFSKKERGTVYGIWSTShNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFF- 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 180 drkekkvntpLMEQIKGVykneklWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGW 259
Cdd:cd17312   178 ----------LRDSPPYV------WVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGL 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 260 LGDKF---NPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCL---------LVAFCAGIGNGTIFKlvpmyfSEQAGIVN 327
Cdd:cd17312   242 LSDKLfggRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLfligffvggPINLIGGAAAQDIGR------KEAAGTAT 315
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1020085945 328 GLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLII 372
Cdd:cd17312   316 GFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLL 360
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
29-373 8.25e-08

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 53.73  E-value: 8.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  29 MPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFVGIGG 108
Cdd:cd17320    22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGA 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 109 AVFSVGVTSLPK--YFPKESHgfvnGIYGVGNAGTAITSFLAPV----IATSVGWRT-----TVQCYLVLLAAFALMNFL 177
Cdd:cd17320   102 AAGSVVARAIVRdlYSGAELA----KIFSLLMMILAIAPALAPLlgglLLLFFGWRAifvflALLGLLLLLLVLLFLPET 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 178 LGDRKEKKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIG 257
Cdd:cd17320   178 LPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLN 257
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 258 GWLGDKFNPFKIL-----IFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFSEQAGIVNGLVSA 332
Cdd:cd17320   258 GRLVRRFGPRRLLrlgllLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGF 337
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1020085945 333 LGGLGGFFPPLILTLLFQLTGH-YAIGFMALSEVALACLIIT 373
Cdd:cd17320   338 LQFLIGALAGALVGLLPNGTALpMGLLILVLGLLALLLLILL 379
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
24-290 1.26e-07

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 52.51  E-value: 1.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  24 ILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLF 103
Cdd:COG0477    32 IVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARAL 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 104 VGIG-GAVFSVGVTSLPKYFPKESHGFVNGIYG-VGNAGTAITSFLAPVIATSVGWRttvqcyLVLLAAFALMNFLLGDR 181
Cdd:COG0477   112 QGIGaGGLMPGALALIAELFPARERGRALGLWGaAIGLGLALGPLLGGLLVAALGWR------WIFLINAPLGLLALVLR 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 182 KEKKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLG 261
Cdd:COG0477   186 LRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLL 265
                         250       260
                  ....*....|....*....|....*....
gi 1020085945 262 DKFNPFKILIFVFIGLTLSGIILSFMPSM 290
Cdd:COG0477   266 LLLLLLLALLLALLLLLLLLLLLLLLALL 294
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
232-381 1.40e-07

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 52.95  E-value: 1.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 232 FGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGIGNGTI 311
Cdd:COG2807    48 LGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLL 127
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1020085945 312 FKLVPMYFSEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTG-HYAIGFMALseVALACLIITVWMYSQEK 381
Cdd:COG2807   128 PGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGwRGALAVWAL--LALLALLLWLPLLRRRP 196
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
15-361 1.42e-07

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 52.97  E-value: 1.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  15 LVIGFMVWVILSSLMPYI------KADIPLTAGQISMVTAVPVILGSVLripIGYWTNRFGARKLFFISFILLLFPVFYI 88
Cdd:cd17330     5 VFLDALGFGIVFPVLPFYvrefnkLGASGYYVGLLQSSYSLGQFLASPL---WGRLSDRYGRKPVLLLSLAGSAVSYVLL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  89 SVANSMMDLIIGGLFVGIGGAVFSVGVTSLPKYFPKESHGFVNGIYGvgnAGTAITSFLAPVIATSVGWRTTVQCYLVLL 168
Cdd:cd17330    82 GLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIIS---AAFGLGFILGPALGGFLSTPYGYALPFLVA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 169 AAFALMNFLLGDRKEKKvntplmeqikgvyknekLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIV 248
Cdd:cd17330   159 AALALLNLVLVLFFLPP-----------------LRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGI 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 249 LATIMR-PIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYF-SEQAGIV 326
Cdd:cd17330   222 AGILAQlLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVpSKEQGKA 301
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1020085945 327 NGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMA 361
Cdd:cd17330   302 QGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLA 336
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
21-374 2.85e-07

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 51.88  E-value: 2.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  21 VWVILSSLMPYIKADIPLTAGQIS-MVTAVPVilGSVLRIPI-GYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLI 98
Cdd:cd17393    14 LMASWATRIPAIKDRLGLSDAALGlLLLALGV--GALVAMPLaGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALA 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  99 IG----GLFVGIGGAVFSVGVTSLPKYFPKESHGFVNGIYGVGNAGTAITSFLAPVIATSVGWRTTVQCYLVLLAA-FAL 173
Cdd:cd17393    92 LAlflfGAANGALDVAMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLGAAAIGAGVSPGVHLLAAAVLLLLAAlVAI 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 174 MNFLLGDRKEKKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIM 253
Cdd:cd17393   172 RALLPGTGEAAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTVG 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 254 RPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFcaGIGNgtifkLVPMYFSE-------QAGIV 326
Cdd:cd17393   252 RLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGL--GLSV-----VVPLAFSAagalpglAAGIA 324
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1020085945 327 NGLVSALGGLGGFFPPLILTLLFQLTGhYAIGFMAlseVALACLIITV 374
Cdd:cd17393   325 VARVATLGYLGFLVGPPLIGFLADATG-LRTAFLV---VALLALLVAL 368
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
134-347 3.02e-07

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 52.22  E-value: 3.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 134 YGVGNAGTAITSFLAPVIATSVGWRTTVQCY------LVLLAAFALMNFLLG------DRKEKKVNTPLMEQIKGVYKNE 201
Cdd:cd17332   142 MFFATIGGLLVTVLPPPLVAYFGGGNASRGYfltaliIGIIGIILLLICFFGtrervvPPEEEKSKLPLLKSLKALLKNR 221
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 202 KLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAgFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSG 281
Cdd:cd17332   222 PFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLL-ILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGL 300
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 282 IILSFMPSMNVYTFgcLLVAFCAGIGNGTIFKLVPMYFSE------------QAGIVNGLVSAL----GGLGGFFPPLIL 345
Cdd:cd17332   301 LLLFFLPPGNLVLI--LVLAVLAGIGYGGANLLPWAMLADvidygelktgkrREGIFYSVMTFFrklgLALAGALVGLIL 378

                  ..
gi 1020085945 346 TL 347
Cdd:cd17332   379 SL 380
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
25-376 3.21e-07

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 51.81  E-value: 3.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  25 LSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFV 104
Cdd:cd17504    15 LSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQ 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 105 GIGGAVFSVGVTSLPKYFPKESHGFVNGIY-GVGNAGTAITSFLAPVIATSVGWRTTVQCYLVLLAAFALMNFLLgDRKE 183
Cdd:cd17504    95 GIGGAVFPLAFALVREEFPPERVPVAQGILsATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLI-DLRL 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 184 KKVNTPLMEQIKGVykneklwflcIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDK 263
Cdd:cd17504   174 LRRRNVLLANITAL----------LAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIAR 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 264 FNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVafcAGIGNGTIFKLVP--MYFS---EQAGIVNGLVSALGGLGG 338
Cdd:cd17504   244 VGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLL---IGIGLGLAFASLPniVVESvppDRTGIATGMNTVLRTIGS 320
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1020085945 339 FFPPLILTLLFQL------------TGHYAIGFMALSEVALACLIITVWM 376
Cdd:cd17504   321 AIGPAIAGAILTTytvsitsggvptEGAYVLAFLIGAALALAALLLSLLI 370
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
13-184 5.23e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 51.02  E-value: 5.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  13 SNLVIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARK---LFFISFILLLFPVFYIS 89
Cdd:COG2271   188 AYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklvLAIGLLLAALALLLLAL 267
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  90 VANSMMDLIIGGLFVGIGGAVFSVGVTSLPKYFPKESHGFVNGI-YGVGNAGTAITSFLAPVIATSVGWRTTVQCYLVLL 168
Cdd:COG2271   268 LPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLvNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALA 347
                         170
                  ....*....|....*.
gi 1020085945 169 AAFALMNFLLGDRKEK 184
Cdd:COG2271   348 LLAALLALLLLRETRK 363
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
24-374 5.88e-07

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 51.07  E-value: 5.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  24 ILSSLMPYIK---ADIPLTAGQISMVTAVPVILGSVLripIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIG 100
Cdd:cd17331    18 LQQPVLPYLTkklGVDSVVFGYLQTTFSVLQLVGGPL---FGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLS 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 101 GLfVGIGGAVFSVGVTSLPKYFPKESH----GFVNGIYGVGnagTAITSFLAPVIATSVGWRTTVQCYLVLLAAFALMNF 176
Cdd:cd17331    95 RL-PSVFMHAMQAAQMVVTDLTDPGERaaalGRLGLSYGIG---MVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVI 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 177 LL---------GDRKEKKVNTPL---MEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTA 244
Cdd:cd17331   171 LLipsntkskrEKEAKESASPPSvfnLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMS 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 245 GFIVLATIMRPIG-GWLGDKFNPFKILIFVFIGLTLSGIILSFMPSmnVYTFGCLLVAFCAG------IGNGTIFKLVPm 317
Cdd:cd17331   251 YAGVLGMVVQGLLvGPLTKRFGERSLLKLSVALLAIGYLLLAFVTT--VWQLLVLLLPLVIGgsvlytVITSLLTKAVP- 327
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1020085945 318 yfSEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITV 374
Cdd:cd17331   328 --PEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
MFS_1 pfam07690
Major Facilitator Superfamily;
206-375 7.88e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 50.49  E-value: 7.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 206 LCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILS 285
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 286 FMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFSEQA-GIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSE 364
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEErGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
                         170
                  ....*....|.
gi 1020085945 365 VALACLIITVW 375
Cdd:pfam07690 161 SLLAAVLLLLP 171
MFS_MCT11_13 cd17423
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ...
39-361 8.53e-07

Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340981 [Multi-domain]  Cd Length: 383  Bit Score: 50.47  E-value: 8.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  39 TAGQISMVTAVPVILGSvLRIPIG-YWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIG-GLFVGIGGA-VFSVGV 115
Cdd:cd17423    36 SAQRVSWITSIGLAVQQ-LASPVGsALSTRYGARPVVMLGGLLSSLGFLLASFATSLLHLYLCiGLLSGLGWAlVFAPTM 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 116 TSLPKYFPKE-SHGFVNGIYGVGNAGTAITSFLApVIATSVGWRTTvqcyLVLLAAFALMNFLLGdrkekKVNTPLMEQI 194
Cdd:cd17423   115 ATVSRYFSRRrSLATGLALTGVGLSSFALSPLFQ-LLLDTYAWRGA----LLLLSALSLHLVPCG-----ALLRPLALPG 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 195 KGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNF----------LVSH---FGLDKVDAGMRTAGFIVLATIMRPIGGWLG 261
Cdd:cd17423   185 DPPAPPRSLSAAFGLSLLTHRAFLRYALATTLIntgyfipyvhLVAHaraLGLGEYQAAFVVSVAAVADAVGRLFSGWLA 264
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 262 DKfNPFKILIFVFIGLTLSGIILSFMPSMNVYT---FGCLLVAFCAGigngtifKLVPMYFSEQAGIVN--------GLV 330
Cdd:cd17423   265 DL-GPLRLLHLLVLWTALTGLSLLLLPLAKVYGsllALAVAYGFCAG-------ALAPLVFSVLPELVGvervlnatGLL 336
                         330       340       350
                  ....*....|....*....|....*....|.
gi 1020085945 331 SALGGLGGFFPPLILTLLFQLTGHYAIGFMA 361
Cdd:cd17423   337 QMIESVGGLLGPPLSGWLRDITGDYTASFLV 367
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
12-377 1.35e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 49.92  E-value: 1.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  12 TSNLVIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVA 91
Cdd:cd17329     6 IGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  92 NSMMDLIIGGLFVGIGGAVFSVGVTSLPKYFPKESHG--FVNGIYGVGNAGTAITSFLAPVIATSVGWRTTVQCYLVLLA 169
Cdd:cd17329    86 HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRtrAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLL 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 170 AFALMNFLLGDRKEKKVNTPLMEQIKG---VYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGL-DKVDAGMRTAG 245
Cdd:cd17329   166 AALVLLFLLPETRPKRRAAEKTEILRGykiVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLgESLLGLLLALN 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 246 FIVLATIMRPIGGWLGdKFNPFKILIF-------VFIGLTLSGIILSFMPSMNVYTFGCLLVafcAGIGNGTIFKLVPmy 318
Cdd:cd17329   246 ALLIVLLQFPVARLVE-RFRLRKILMIgillfaiGFAVLAFANTLAVLILAMIVLTLGEMLV---FPAVQTLVAALAP-- 319
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1020085945 319 fSEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGhYAIGFMALSEVALACLIITVWMY 377
Cdd:cd17329   320 -PDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLG-PGLPWLILAALGLIAAALLLGLQ 376
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
66-312 2.11e-06

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 49.10  E-value: 2.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  66 NRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFVGIGGAVFSVGVTSLPKY-FPKESH----GFVNGIYGVgnaG 140
Cdd:cd17502    55 DLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADlVPPRERgkyqGYIGAVFGI---A 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 141 TAITSFLAPVIATSVGWRTtvqCYLVLLAAFALMNFLLgdrkekkvntplmeqikgvyknEKLWFLCIFYFLTFGSFVAF 220
Cdd:cd17502   132 SVAGPLIGGAFTDHLSWRW---CFYINLPIGGLALALL----------------------RTILLSSIFGFLFGGALFGL 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 221 TVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLV 300
Cdd:cd17502   187 IYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIGTILMSVGAGLLTTLTLDTSKWLLIGY 266
                         250
                  ....*....|..
gi 1020085945 301 AFCAGIGNGTIF 312
Cdd:cd17502   267 LILLGLGLGIGF 278
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
37-368 4.69e-06

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 48.32  E-value: 4.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  37 PLTAGQISMVTAVPVILGSVLripIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFVGIGGAVFSVGV- 115
Cdd:cd17477    30 TALIGLVASAYYLGILLGSPL---VPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSe 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 116 TSLPKYFPKESHGFVNGIYGVGNAGTAITSFLAPVIATSVGWRTTVQCYLVLLAAFALMNFLLGDRKEKKVNTPLmeQIK 195
Cdd:cd17477   107 SWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEEAESI--SLR 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 196 GVYKNEKLWFLCIFYF-LTFGSFVAFtvyLPNFLVSHfGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVF 274
Cdd:cd17477   185 RLLRIAPLALLGAFVAgFLEGAFYSL---LPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCA 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 275 IGLTLSGIILSFMPSmnvYTFGCLLVAFCAGIGNGTIFKLVPMYFSEQAG-----IVNGLVSALGGLGGFFPPLILTLLF 349
Cdd:cd17477   261 LLGALAALLLPLVPG---LPLALLVLLFLWGGAAGPLYTLALALAGDRLPgdelvAANAALLLLYGLGSVIGPLLAGALM 337
                         330
                  ....*....|....*....
gi 1020085945 350 QLTGHYAIgFMALSEVALA 368
Cdd:cd17477   338 DAFGPHGL-FLFLAAVALL 355
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
23-344 4.95e-06

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 48.12  E-value: 4.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  23 VILSSLMPYIKADI---PLTAGQISMVTAVPVILGSVLripIGYWTNRFGARKLFFISfiLLLFPVFYI--SVANSMMDL 97
Cdd:TIGR00895  34 AAMGFAAPAISAEWgldPVQLGFLFSAGLIGMAFGALF---FGPLADRIGRRRVLLWS--ILLFSVFTLlcALATNVTQL 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  98 IIGGLFVGIG-GAVFSVGVTSLPKYFPKESHGFVNGIYGVG-NAGTAITSFLAPVIATSVGWRTT--VQCYLVLLAAFAL 173
Cdd:TIGR00895 109 LILRFLAGLGlGGLMPNLNALVSEYAPKRFRGTAVGLMFCGyPIGAAVGGFLAGWLIPVFGWRSLfyVGGIAPLLLLLLL 188
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 174 MNFL------LGDRKEKKVNTPLMEQI--------------KGVYKNEKLWFLCIF--------------YFLTFGSFVA 219
Cdd:TIGR00895 189 MRFLpesidfLVSKRPETVRRIVNAIApqmqaeaqsalpeqKSTQGTKRSVFKALFqgktaritvllwllYFMLLVGVYF 268
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 220 FTVYLPnFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLL 299
Cdd:TIGR00895 269 LTNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAI 347
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1020085945 300 VAFCAGIGNGTIFKLVPMYFSEQA-GIVNGLVSALGGLGGFFPPLI 344
Cdd:TIGR00895 348 AGFFVNGGQSGLYALMALFYPTAIrATGVGWAIGIGRLGAIIGPIL 393
MFS_LacY cd06172
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY ...
19-232 6.73e-06

LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY proton/sugar family (also called LacY/RafB family) symporters are integral membrane proteins responsible for the transport of specific beta-glucosides into the cell accompanied by the import of a proton. Members include lactose permease (LacY), raffinose permease (RafB), and sucrose permease, which facilitate the transport of beta-galactosides, raffinose, and sucrose, respectively. The prototypical member, LacY, contains 12 transmembrane helices connected by hydrophilic loops with both N and C termini on the cytoplasmic face. The LacY/RafB permease family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340862 [Multi-domain]  Cd Length: 389  Bit Score: 47.61  E-value: 6.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  19 FMVWVILSSLMP-YIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARK--LFFISFILLLFPVFYISV----- 90
Cdd:cd06172    12 FFIWSASFSFFPiWLTQINHLSGSETGIVFSANSLFALLFQPVYGLISDKLGLKKhlLWFISGLLVLFGPFFIFVygpll 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  91 -ANSMMDLIIGGLFVGiggAVFSVGVTSLPKYFPKES--HGFVNG-IYGVGNAGTAITSFLAPVIATsvgWRTTVQCYLV 166
Cdd:cd06172    92 qSNILLGAIVGGIYLG---FAFLAGCGAIESYIERVSrrFNFEYGrARMWGSLGWALAAFFAGILFN---INPNINFWLG 165
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1020085945 167 LLAAFALMNFLLGDRKE---------KKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHF 232
Cdd:cd06172   166 SGFALILLLLLLFAKPEdsdtaaaagANASSVSLKDVLELFRMPKFWFFILFVIGVSCFYDVFDQQFPPYFTSLF 240
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
27-177 1.04e-05

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 47.15  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  27 SLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFVGI 106
Cdd:cd17370   220 AFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGL 299
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1020085945 107 G-GAVFSVGVTSLPKYFPKESHGFVngiYGVGNAGTAITSFLAPVIA----TSVGWRTTVqCYLVLLAAFALMNFL 177
Cdd:cd17370   300 YmGAQESIERAAVADLVPAELRGTA---YGLFNTVVGIGWLLASLIAgylwDLISPSAAF-LFSAVLALIALLLLL 371
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
220-380 1.22e-05

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 46.99  E-value: 1.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 220 FTVYLPnFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPfkiLIFVFIGLTLSGIILSFMPSMNVYTFGCLL 299
Cdd:TIGR00881  14 FALAMP-YLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNP---RVFLPIGLILCAIVNLFFGFSTSLWVMAAL 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 300 VAFCA---GIGNGTIFKLVPMYFSE-QAGIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITVW 375
Cdd:TIGR00881  90 WALNGifqGMGWPPCGRTVTKWFSRsERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFL 169

                  ....*
gi 1020085945 376 MYSQE 380
Cdd:TIGR00881 170 LLRDS 174
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
14-174 1.79e-05

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 46.44  E-value: 1.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  14 NLVIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFIL---LLFPVFYISV 90
Cdd:cd17316   186 WFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILsgiLALPLFYLLS 265
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  91 ANSMMDLIIGGLFVGIGGAVFSVGVTSLPKYFPKESHGFVNGI-YGVGNAGTAITSFLAPVIATSVGWRTTVQCYLVLLA 169
Cdd:cd17316   266 GSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLsYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLA 345

                  ....*
gi 1020085945 170 AFALM 174
Cdd:cd17316   346 IVALI 350
2A0108 TIGR00886
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
203-349 3.12e-05

nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]


Pssm-ID: 273322 [Multi-domain]  Cd Length: 354  Bit Score: 45.37  E-value: 3.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 203 LWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKilifVFIGLTLSGI 282
Cdd:TIGR00886   3 LFFSWFGFFLSFLVWFAFSPLAVFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRY----TTALSLLLLA 78
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1020085945 283 ILSFMPSMNVYTF-GCLLVAFCAGIGNGTIFKLVPM----YFSEQAGIVNGLVSALGGLGG-----FFPPLILTLLF 349
Cdd:TIGR00886  79 IPCLWAGLAVQSYsVLLLIRLFIGIAGGSFASCMPWisffFPKKIQGTALGLAAGWGNMGGgvaqfVMPPIIGSLIF 155
MFS_FucP_like cd17394
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ...
164-343 3.37e-05

Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340952 [Multi-domain]  Cd Length: 401  Bit Score: 45.68  E-value: 3.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 164 YLVLLAAFALMNFLLGDRKEKKVNTPLME------QIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVS-HFGLDK 236
Cdd:cd17394   184 YLGIALVLLLLAVLILLSKLPEIEAAEAEalgskgTLLRLLKNPHLRLGVLAIFFYVGAEVAIWSFLINYLMEyIAGLTE 263
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 237 VDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKIL-IFVFIGLTLSGIILSFMPSMNVYTFgcLLVAFCAGIGNGTIFKLV 315
Cdd:cd17394   264 TSAATFVSYYWGGFMVGRFLGTALLKKISPKKLLaVFALLGLLLLLGAIFTGGMVALYAL--VLVGFFNSIMFPTIFSLA 341
                         170       180
                  ....*....|....*....|....*....
gi 1020085945 316 PMYFSEQAGIVNG-LVSALGGlGGFFPPL 343
Cdd:cd17394   342 LKGLGKHTKTGSGlLVMAIVG-GAVVPLI 369
cynX PRK09705
putative cyanate transporter; Provisional
28-373 3.45e-05

putative cyanate transporter; Provisional


Pssm-ID: 236614 [Multi-domain]  Cd Length: 393  Bit Score: 45.57  E-value: 3.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  28 LMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFVGIG 107
Cdd:PRK09705   31 LLPQLRQASGMSFSVAALLTALPVVTMGGLALAGSWLHQHVSERRSVAISLLLIAVGALMRELYPQSALLLSSALLGGVG 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 108 GAVFSVGVTSLPKYFPKESHGFVNGIY-----GVGNAGTAITSFLAPVIATsvgWRTTVQCYlVLLAAFALMNFLLGDRK 182
Cdd:PRK09705  111 IGIIQAVMPSVIKRRFQQRTPLVMGLWsaalmGGGGLGAAITPWLVQHSET---WYQTLAWW-ALPAVVALFAWWWQSAR 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 183 EKKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVsHFGldkvDAGMRTAGFIVLATIMRPIGGWL-- 260
Cdd:PRK09705  187 EVASSHKTTTTPVRVVFTPRAWTLGVYFGLINGGYASLIAWLPAFYI-EIG----ASAQYSGSLLALMTLGQAAGALLmp 261
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 261 -GDKFNPFKILIFVFIGLTLSGII-LSFMPSmnvyTFGCLLVAFCaGIGNGTIFKL---VPMYFSEQAGIVNGLVSALGG 335
Cdd:PRK09705  262 aMARHQDRRKLLMLALVLQLVGFCgFIWLPL----QLPVLWAMVC-GLGLGGAFPLcllLALDHSVQPAIAGKLVAFMQG 336
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1020085945 336 LGGFFP---PLILTLLFQLTGHYAIGFMALSEVALACLIIT 373
Cdd:PRK09705  337 IGFIIAglaPWFSGVLRSISGNYLMDWAFHALCVVGLMIIT 377
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
24-137 3.59e-05

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 45.83  E-value: 3.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  24 ILSSLMPYIKADIPLTAGQISMVTAvPVILGSVLRIPIGYW-TNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGL 102
Cdd:TIGR00711  20 IVNVAIPTIAGDLGSSLSQVQWVIT-SYMLANAISIPLTGWlAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRV 98
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1020085945 103 FVGI-GGAVFSVGVTSLPKYFPKESHGFVNGIYGVG 137
Cdd:TIGR00711  99 IQGFgGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLT 134
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
20-178 1.36e-04

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 43.68  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  20 MVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLII 99
Cdd:cd17372    13 MEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLII 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 100 GGLFVGIGGAVFSVGVTSLPKYFPKESHGFVNGIYGV-GNAGTAITSFLAPVIATSVGWRttvqcYLVLLAAFALMNFLL 178
Cdd:cd17372    93 LRCLVGLGLGGGPQLASWYLEFLPAKSRGTWMVLFSVfWTVGTIFEASLAWLVMPRLGWR-----WLLAFSSVPSSLLLV 167
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
18-178 1.38e-04

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 43.77  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  18 GFMVWVILSSLMPYIKADIPlTAGQISMVTAVPVILGSVLRIPIGYWTNRFGaRKLFFISFILLLFPVFYI-SVANSMMD 96
Cdd:cd06179    10 QLFGVTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFG-RRWFFIGGNLLGVVGSIVaGTAKSVNM 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  97 LIIGGLFVGIGGAVFSVGVTSLPKYFPKESHGFVNGIYgvgNAGTAITSFLAPVIATSV------GWRTtvqCYLVLLAA 170
Cdd:cd06179    88 LIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVV---NLVASPGSALGPLIAGALveanaaGWRW---IFYINAIF 161

                  ....*...
gi 1020085945 171 FALMNFLL 178
Cdd:cd06179   162 NALALILL 169
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
206-381 1.39e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 43.57  E-value: 1.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 206 LCIFYFLTFGSFVAFTVYLPNFLVShFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILS 285
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQS-FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 286 FMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFSE-QAGIVNGLVSALGGLGGFFPPLILTLLF-QLTGHYAIGFMALS 363
Cdd:cd06174    80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPErERGRALGLLQAFGSVGGILGPLLGGILAsSLGFGWRAVFLIAA 159
                         170
                  ....*....|....*...
gi 1020085945 364 EVALACLIITVWMYSQEK 381
Cdd:cd06174   160 ALALLAAILLLLVVPDPP 177
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
23-362 3.09e-04

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 42.45  E-value: 3.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  23 VILSSLMP-YIKADIPLTAGQ-----ISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFilllfpvFYISVANSMM- 95
Cdd:COG2270    28 VITTFVFPpYFTSVAALGDPAaatalWGYALAIAGLLVALLAPVLGAIADRSGRKKPFLAFF-------TLLGVLATAAl 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  96 ------DLIIGGLFVGIGGAVFSVGVTS----LPKYFPKESHGFVNGI-YGVGNAGTAITSFLAPVIATSVGWRTTVQCY 164
Cdd:COG2270   101 ffvapgGLWLGLLLFVLANIGFEGSLVFynafLPDIATPEEIGRVSGLgWALGYLGGVLLLLINLALFLKPEAFGLPDAG 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 165 L----------VLLAAFAL-MNFLLGDRKEKKVNTPL------MEQIKGVYKNEK-----LWFLCIFYFLTFGSFVAFTv 222
Cdd:COG2270   181 EavrisflltaLWWLLFALpLFLFLPERPRPGPAPPRgavragFRELRRTLRELRryrdlLRFLLAYFFYRDGVQTVIA- 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 223 YLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYtfgcLLVAF 302
Cdd:COG2270   260 FAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAF----WILGL 335
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1020085945 303 CAGIGNGTIF--------KLVPmyfSEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMAL 362
Cdd:COG2270   336 LIGLVMGGIQalsrsllaRLIP---PGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGSQRLGILSL 400
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
206-372 3.54e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 42.20  E-value: 3.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 206 LCIFYFLTFGSFVAFTVYLPNFlVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILS 285
Cdd:cd17489     1 ILLANFFFFLSFYLLLPVLPLY-AHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 286 FMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYF-SEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSE 364
Cdd:cd17489    80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIIpPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVL 159

                  ....*...
gi 1020085945 365 VALACLII 372
Cdd:cd17489   160 ALLALLLV 167
MFS_CynX_like cd17410
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of ...
26-373 5.71e-04

Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli cyanate transport protein CynX and similar proteins. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The gene encoding CynX is part of the cyn operon that also includes cynS, encoding cynase, which catalyzes the reaction of cyanate with bicarbonate to give ammonia and carbon dioxide, and cynT, which encodes a carbonic anhydrase. The CynX-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340968 [Multi-domain]  Cd Length: 372  Bit Score: 41.63  E-value: 5.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  26 SSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFVG 105
Cdd:cd17410    19 GPLLNEIRAATGLSFQVASLLTVLPVLCMGLVALLGPWLARRVGERRGVALSLLAIAAACLWRLWSGTGPTLIASALLGG 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 106 IGGAVFSVGVTSLPKYFPKESHGFVNGIYGVG-NAGTAITSFLAPVIA-TSVGWRTTVQCYLVlLAAFALMNFLLGDRKE 183
Cdd:cd17410    99 LGIAIIQALVPGLIKRRFPARVPLAMGLYSASlMAGGGLAASLSPRLAqHSAGWQLGLGIWAV-PALVALVLWWRQPPRE 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 184 KKVNTPLMEQIKgVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVShFGLDKVDAGmrtaGFIVLATIMRPIGGW---- 259
Cdd:cd17410   178 VAPSDTAGPGVR-FFRNRRAWLLALYFGLINAGYTSMIAWLPAYYLE-LGWSAQDSG----SLLGFMTIFQVLGALvmpa 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 260 LGDKFNPFKILIFVFIGLTLSGII-LSFMPsmnvyTFGCLLVAFCAGIGNGTIFKLVPM----YFSE--QAGIVNGLVSA 332
Cdd:cd17410   252 LARRSADRRPLLMGALAAQLAGFLgLILMP-----QSLPLLWVALIGLGLGACFSLGLIlaldHLRKprAAGQLAAFVQG 326
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1020085945 333 LGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIIT 373
Cdd:cd17410   327 IGFIITGISPWIAGWLRDSTGSFQAAWLLLAASVVAMLLLT 367
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
55-377 1.07e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 40.66  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  55 SVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFVGIGgAVFSVGVTSLPKYFPKESHGFVNGIY 134
Cdd:cd17472    46 AIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSG-AISSVVMALLADLTREENRTKAMALI 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 135 GVGNAGTAITSF-LAPVIATSVG-----WRTTVqcyLVLLAAFALMNFLLGDRKEKKVNTPLMEQIKGVYKNEKLWFLCI 208
Cdd:cd17472   125 GASIGIAFAISMvLGPLLAAHLGvsglfLITAI---LSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLLRLDF 201
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 209 FYFLTFGSFVAFTVYLPNFLVSHfGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFN-PFKILIFVFIGLTLSGIILSFM 287
Cdd:cd17472   202 SIFILHFVLMAFFYILPLLLTQL-GGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGkMKQVFVSSILLIAVGFLLLLFA 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 288 PSMNVYTFGCLLVAFcagIGNGTIFKLVPMYFSEQA-----GIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIgFMAL 362
Cdd:cd17472   281 ATSLWLLIIGLIIFF---IGFNLLEALLPSLVSKIApkeyrGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSV-FLTI 356
                         330
                  ....*....|....*
gi 1020085945 363 SEVALACLIITVWMY 377
Cdd:cd17472   357 LILALLWLLVSFLLP 371
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
24-374 1.13e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 40.75  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  24 ILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLF 103
Cdd:cd17371    17 LLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRAL 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 104 VGIG-GAVFSVGVTSLPKYFPKESHGFVNGIYGVGNA-----GTAITSFLAPVIATSVGWRttvqcYLVLLAAF-ALMNF 176
Cdd:cd17371    97 AGLGfGGEWAAGAALMAEYVPARHRGKALGYVQSGWAvgwllATLLAALLFPLLPPEIAWR-----VLFLLGALpALLVL 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 177 LL---------------GDRKEKKVNTPLMEQIKGVYKNEKLWFLcIFYFLTFGSFvAFTVYLPNFLVSHFGLDKVDAGM 241
Cdd:cd17371   172 FIrrfvkeppqwqaaraARRHFADRPSLRELFSPPLLRTTLLASL-LATGALGGYY-GITTWLPSYLTGERGLSFEGSAG 249
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 242 RTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSmnvyTFGCLLVA-FCAGIGNGTIFKLVPMYFS 320
Cdd:cd17371   250 YLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPL----SPTLILILgFPLGFFASGPFSGMGAYLT 325
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 321 E------QAGIVNGLVSALGGLGGFFPPLILTLLfqLTGHYAIGFMALSEVALACLIITV 374
Cdd:cd17371   326 ElfptavRATAQGFCYNVGRIIGALFPFLVGFLA--TSGSLGTAIAVFAAVYYIAGLVLA 383
PRK03893 PRK03893
putative sialic acid transporter; Provisional
22-156 1.70e-03

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 40.45  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  22 WVILSSLMPYIKADIPLTAGQISMV-------TAVPVILGsvlripiGYWTNRFGARKLFFISFI---LLLFPVFYISVA 91
Cdd:PRK03893  292 WPIQALLPTYLKTDLGYDPHTVANVlffsgfgAAVGCCVG-------GFLGDWLGTRKAYVCSLLisqLLIIPVFAIGGA 364
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1020085945  92 NSmmdLIIGGLFvgIGGAVFSVGVTS-LPK----YFPKESH----GFvngIYGVGNAGTAITSFLAPVIATSVG 156
Cdd:PRK03893  365 NV---WVLGLLL--FFQQMLGQGISGlLPKliggYFDTEQRaaglGF---TYNVGALGGALAPILGALIAQRLD 430
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
13-179 2.08e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.89  E-value: 2.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  13 SNLVIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFIL--LLFPVFYISV 90
Cdd:COG2211   236 AYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLaaLGLLLLFFLG 315
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  91 ANSMMDLIIGGLFVGIGGAVFSVGVTSL--------PKYFPKESHGFVNGIYGVGN-AGTAITSFLAPVIATSVGWRTTV 161
Cdd:COG2211   316 PGNLWLLLVLAALAGIGLGAILVLPWAMladvvdydEWKTGRRREGLYFGIFTFAIkLGQALAGALAGLLLALFGYVAGA 395
                         170
                  ....*....|....*...
gi 1020085945 162 QCYLVLLAAFALMNFLLG 179
Cdd:COG2211   396 AQSPSALTGIRLLFFLLP 413
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
230-289 4.00e-03

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 39.14  E-value: 4.00e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1020085945 230 SHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKIL---IFVFIGLTLSGiilSFMPS 289
Cdd:cd17328    27 SDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILavgILIWSAATLLS---SFAPN 86
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
211-376 5.13e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 38.69  E-value: 5.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 211 FLTFGSFVAFTVYLpNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSM 290
Cdd:cd17352    13 FFTDGILNSFGVLF-VELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 291 NVYtfgCLLVAFCAGIGNGTIFK----LVPMYFSEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGhYAIGFMALSEVA 366
Cdd:cd17352    92 WQL---YLTYGVLGGLGLGLIYSpaivIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYG-WRGALLILGGLC 167
                         170
                  ....*....|
gi 1020085945 367 LACLIITVWM 376
Cdd:cd17352   168 LNLCVCGLLL 177
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
25-113 5.86e-03

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 38.71  E-value: 5.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  25 LSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFV 104
Cdd:cd17358    25 LPSLMSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLA 104

                  ....*....
gi 1020085945 105 GIGGAVFSV 113
Cdd:cd17358   105 GFGGGAASV 113
MFS_NIMT_like cd17409
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of ...
25-371 7.60e-03

2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli 2-nitroimidazole transporter (NIMT), also called YeaN, and similar proteins. NIMT confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. The NIMT-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340967 [Multi-domain]  Cd Length: 374  Bit Score: 38.01  E-value: 7.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  25 LSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISvANSMMDLIIGGLFV 104
Cdd:cd17409    18 VAPLLDTIRESFGLSTAQAGLLTTLPLLAFALFSPLAAKLARRYGLERSLFAALLLIAAGIALRS-TGSVWALYLGTAII 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 105 GIGGAVFSVGVTSLPK-YFPkESHGFVNGIY----GVGNA-GTAITSFLAPVIATsvGWRTTVQCYLVL-LAAFALMNFL 177
Cdd:cd17409    97 GAGIAIGNVLLPSLLKrDFP-ARVATLTGAYaltmGVGAAlGSALVVPLAQVLAF--GWQLALGAFLVFpLVAALIWLPQ 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 178 LGDRKEKKVNTPLMEQIKGVYKNEKLWFLCIfyFLTFGSFVAFTV--YLPNFLVSHfGLDKVDAGmRTAGFIVLAT---- 251
Cdd:cd17409   174 LRRHTSPAADTAKPPHGGSVWRSPLAWQVTL--FLGLNSFIYYVLvgWLPSILTDA-GYSAAQAG-SLHGLLQLATavpg 249
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 252 -IMRPIGGWLGDKfnpfKILIFVFIGLTLSGII-LSFMPSMnvytfgCLLVAFCAGIGNGTIFKLVPMYFS------EQA 323
Cdd:cd17409   250 lLLIPVLARMKDQ----RLLAVLVSLLGAVGLIgLLLAPSL------AILWVILFGFGSGAGFILGLAFIGlrtssaHQA 319
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1020085945 324 GIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLI 371
Cdd:cd17409   320 AALSGMAQCVGYLLAATGPMLVGALHDLTGSWSVPLLLCAALALLMAI 367
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
231-323 7.76e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 37.94  E-value: 7.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 231 HFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVafcaGIGNGT 310
Cdd:cd17315    28 GFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLL----GLGVGL 103
                          90
                  ....*....|...
gi 1020085945 311 IFKLVPMYFSEQA 323
Cdd:cd17315   104 ASVLVPLYISEIA 116
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
203-376 8.07e-03

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 37.87  E-value: 8.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 203 LWFLCIFYFLTFGSFVAFTVYLPnFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGI 282
Cdd:COG0477    16 LLALALGTFLEGLDFTIVNVALP-SIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 283 ILSFMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFS-EQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIgFMA 361
Cdd:COG0477    95 LCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPaRERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWI-FLI 173
                         170
                  ....*....|....*
gi 1020085945 362 LSEVALACLIITVWM 376
Cdd:COG0477   174 NAPLGLLALVLRLRL 188
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
73-375 9.23e-03

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 38.37  E-value: 9.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945   73 LFFISFILLLFP-------------VFYISVANSMMDLII-----GGLFVGIGGAVFSVGVTS----------LPKYFPK 124
Cdd:PRK08633    55 LFLLPFLLLSSPagfladkfsknrvIRIVKLFEVGLTLLIvlayyLGWFWLAFAVTFLLGAQSaiyspakygiIPELVGK 134
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  125 ESHGFVNGIYGVGN-----AGTAITSFLAPVIATSVG-------WRTTVQCYLV----LLAAFALMNF-----LLGDRKE 183
Cdd:PRK08633   135 ENLSRANGLLEAFTivailAGTALFSFLFESVNGNTPseilgriAPAGLVLLAVavlgLIFAYRLPKVpaaapEVFDKKK 214
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  184 KKVNTPLMEQIKGVYKNEKLWfLCIF---YFLTFGSFVafTVYLPNFLVSHFGLDKVDAgmrTAGFIVLATIMRPIGGWL 260
Cdd:PRK08633   215 YLFPKLLWRNLKLLRSDRVLW-LAIIglsYFWFISQLA--QANFPAYAKEVLGLDNTFQ---VQYLLAASAIGIGIGSLL 288
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  261 GDKFNPFKI---LI-FVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGigngtIFkLVPM-----YFSEQA--GIV--- 326
Cdd:PRK08633   289 AGRLSGRHIelgLVpLGALGLALSLFLLPTAPSLASVLVLFFLFGFSAG-----LF-IVPLnaliqFRAPEKelGKVlaa 362
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1020085945  327 NGLVSALGGLGGffppLILTLLFQLTGHYAIG-FMALSEVALACLIITVW 375
Cdd:PRK08633   363 NNFLQNVGMLLF----LALTTLFSGLGLSPAGlFYLIALVTLIGTLYTLL 408
PRK12307 PRK12307
MFS transporter;
28-358 9.38e-03

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 37.99  E-value: 9.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945  28 LMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFVGIG 107
Cdd:PRK12307   40 IMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMG 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 108 GA-----VFSVGVTSLPKYFPKESHGFVNGIYGVGNagtAITSFLAPVIATSVGWRTTvqcYLVLLAAFALMNFLLGDRK 182
Cdd:PRK12307  120 MAgeyacASTYAVESWPKHLKSKASAFLVSGFGIGN---IIAAYFMPSFAEAYGWRAA---FFVGLLPVLLVIYIRARAP 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 183 EKK----------------VNTPLMEQIKGVYKNEKLWF-LCIFY--FLTFGSFVAFTVYLPNFLVSH-FGLDKVDAGMR 242
Cdd:PRK12307  194 ESKeweeaklsgkgkhsqsAWSVFSLSMKGLFNRAQFPLtLCVFIvlFSIFGANWPIFGLLPTYLAGEgFDTGVVSNLMT 273
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 243 TAGF-IVLATImrpIGGWLGDKFNPFKILIfvfIGLTLSGII---LSFMPSMNVYTFG-CL--LVAFCAGIGnGTIFKLV 315
Cdd:PRK12307  274 AAAFgTVLGNI---VWGLCADRIGLKKTFS---IGLLMSFLFifpLFRIPQDNYLLLGaCLfgLMATNVGVG-GLVPKFL 346
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1020085945 316 PMYF-SEQAGIVNGLVSALGGLGGFFPPLILTLlfqLTGHYAIG 358
Cdd:PRK12307  347 YDYFpLEVRGLGTGLIYNLAATSGTFNSMAATW---LGITMGLG 387
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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