|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
8-375 |
5.12e-90 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 276.44 E-value: 5.12e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 8 LSLQTSNLVIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFY 87
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 88 ISVA-NSMMDLIIGGLFVGIGGAVFSVGVTSLPKYFPKE-SHGFVNGIYGVGNAGTAITSFLAPVIA-------TSVGWR 158
Cdd:cd17341 81 LALAvSSYWGLLVLGFLLGFAGANFASGQPWASFWFPKEkIGGAAGGIAGAGNMGVAVSQLLAPLIAgaivfdgGFVGWR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 159 TTVQCYLVLLAAFALMNFLLGDR--KEKKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDK 236
Cdd:cd17341 161 NAFFVPGILLAIAAVLVLLFGDDlpTGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 237 VDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAF-----CAGIGNGTI 311
Cdd:cd17341 241 VTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFvalglGAGAGNGSV 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1020085945 312 FKLVPMYFSEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITVW 375
Cdd:cd17341 321 FRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLVWL 384
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
7-381 |
1.63e-83 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 259.81 E-value: 1.63e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 7 QLSLQTSNLVIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVF 86
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 87 YISVANSMMDLIIGGLFVGIG-GAVFSVGVTSLPKYFPKESHGFVNGIY-GVGNAGTAITSFLAPVIATSVGWRTTVQCY 164
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGgGGSFAVGIALVSKWFPPDRRGLALGLAaGGGNLGAAVAAFLAPLLIAAFGWRNAFLIL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 165 LVLLAAFALMNFLLGDRKEKKVNTP---LMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGM 241
Cdd:COG2223 166 GILLLVVAVLAWLFLRDPPAGAAAAakaSLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 242 RTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMP-SMNVYTFGCLLVAFCAGIGNGTIFKLVPMYF- 319
Cdd:COG2223 246 LAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFp 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1020085945 320 SEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITVWMYSQEK 381
Cdd:COG2223 326 TKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPR 387
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
17-338 |
3.39e-50 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 172.49 E-value: 3.39e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 17 IGFMVWVILSSLMPY-IKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVAN-SM 94
Cdd:TIGR00886 12 LSFLVWFAFSPLAVFlIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVqSY 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 95 MDLIIGGLFVGIGGAVFSVGVTSLPKYFPKESHGFVNGIY-GVGNAGTAITSFLAPVIA------------TSVGWRTTV 161
Cdd:TIGR00886 92 SVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTALGLAaGWGNMGGGVAQFVMPPIIgslifgggqpahLAWGWAFVI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 162 QCYLVLLAAFALMNFLLGDR-KEKKVNTPLM-EQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDA 239
Cdd:TIGR00886 172 VPAGILLLPALLIFFVGADTpPGKPATGKLSfKEALKVFGNRHTWILALLYSVTFGSFLGVSSIFAMLFKDQFGLSKVQA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 240 GMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLS--GIILSFMPSMNVYTFGCLLVAFC--AGIGNGTIFKLV 315
Cdd:TIGR00886 252 GAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGafLVVLGLVSDGSLAAFIVLFVALFffAGAGNGSTFALV 331
|
330 340
....*....|....*....|...
gi 1020085945 316 PMYFSEQAGIVNGLVSALGGLGG 338
Cdd:TIGR00886 332 PHIFRRATGAVSGLIGAIGNLGG 354
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
20-376 |
2.59e-36 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 136.54 E-value: 2.59e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 20 MVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLII 99
Cdd:COG2807 32 PAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 100 GGLFVGIGGAVFSVGVTSLPK-YFPKEShGFVNGIYGVG-NAGTAITSFLAPVIATSVGWRTTVQCYLVL-LAAFALMNF 176
Cdd:COG2807 112 GTALIGAGIAVGNVLLPGLIKrWFPDRV-GLMTGLYTAAmGLGAALAAGLTVPLAAALGWRGALAVWALLaLLALLLWLP 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 177 LLGDRKEKKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHfGLDKVDAGMRTAGFIVLATIMRPI 256
Cdd:COG2807 191 LLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 257 GGWLGDKFNPFKILIFVFIGLTLSGII-LSFMPSMNVYtfgclLVAFCAGIGNGTIFKLVPMYFS------EQAGIVNGL 329
Cdd:COG2807 270 VPLLADRLGDRRPLLLLLGLLGLAGLLgLLLAPGSLPW-----LWAVLLGLGQGGLFPLALTLIGlrartpAEAAALSGM 344
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1020085945 330 VSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITVWM 376
Cdd:COG2807 345 AQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-376 |
1.22e-31 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 123.06 E-value: 1.22e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 16 VIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMM 95
Cdd:COG2271 20 FLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFW 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 96 DLIIGGLFVGIG-GAVFSVGVTSLPKYFPKESHGFVNGIYGVG-NAGTAITSFLAPVIATSVGWRTTVQCYLVLLAAFAL 173
Cdd:COG2271 100 QLLLLRFLLGLGeAGFFPAALKLIAEWFPPKERGRALGIFNAGgPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLAL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 174 MNFllgdrkekkvntplmeqikgvykneklWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIM 253
Cdd:COG2271 180 LRF---------------------------WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 254 RPIGGWLGDKFNPFK--ILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFS-EQAGIVNGLV 330
Cdd:COG2271 233 SLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLV 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1020085945 331 SALGGLGGFFPPLILTLLFQLTGhYAIGFMALSEVALACLIITVWM 376
Cdd:COG2271 313 NTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLL 357
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
16-338 |
2.32e-30 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 119.31 E-value: 2.32e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 16 VIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMM 95
Cdd:COG2814 20 FLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLW 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 96 DLIIGGLFVGIGGAVFSVGVTSL-PKYFPKESHGFVNGIYGVG-NAGTAITSFLAPVIATSVGWRTTVQCYLVLLAAFAL 173
Cdd:COG2814 100 LLLAARFLQGLGAGALFPAALALiADLVPPERRGRALGLLGAGlGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 174 MNFLLGDRKEKKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIM 253
Cdd:COG2814 180 LLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLG 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 254 RPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFS-EQAGIVNGLVSA 332
Cdd:COG2814 260 ALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPpEARGRASGLYNS 339
|
....*.
gi 1020085945 333 LGGLGG 338
Cdd:COG2814 340 AFFLGG 345
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
16-374 |
5.97e-26 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 107.27 E-value: 5.97e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 16 VIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMM 95
Cdd:cd17319 13 VINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLT 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 96 DLIIGGLFVGIG-GAVFSVGVTSLPKYFPKESHGFVNGIYGVGNA-GTAITSFLAPVIATSVGWRttvqcylVLLAAFAL 173
Cdd:cd17319 93 SLYVLRFLLGVAeAGFFPGAIKALAEWFPARERGRATGLFNSGAPlGAAIGPPLSGWLLLLFGWR-------WAFIIEGL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 174 MNFLLGdrkekkvntplmeqIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIM 253
Cdd:cd17319 166 LGLLLA--------------VLWWFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 254 RPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMP-SMNVY-TFGCLLVA-FCAGIGNGTIFKLVPMYFS-EQAGIVNGL 329
Cdd:cd17319 232 MILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYlTTSPVvAVILLSLAgFGIGAASPVFWSLPADLLPgEAAATAGGL 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1020085945 330 VSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITV 374
Cdd:cd17319 312 INSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVL 356
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
15-375 |
2.07e-24 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 103.40 E-value: 2.07e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 15 LVIGFMVWvILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSM 94
Cdd:COG0738 18 FLWGFATA-LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 95 MDLIIGGLFVGIGGAVFSVGVTSL-PKYFPKESHGFVNGIYGVGNAGTAITSFLAPVIATSVGWRTTVQCYLVLLAAFAL 173
Cdd:COG0738 97 PLLLLALFLLGLGLGLLDVAANPYvAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 174 MNFLL------GDRKEKKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFI 247
Cdd:COG0738 177 LALLFlrsklpEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 248 VLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFSEQAGIVN 327
Cdd:COG0738 257 GGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAV 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1020085945 328 GLVSALGGLGGFFPPLILTLLFQLTG-HYAIGFMALSEVALACLIITVW 375
Cdd:COG0738 337 SAVLIMGIVGGAIGPPLIGFLADAFGlRAAFLVPLVCYLLILLLALALK 385
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
13-342 |
4.58e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 101.73 E-value: 4.58e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 13 SNLVIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVAN 92
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 93 SMMDLIIGGLFVGIG-GAVFSVGVTSLPKYFPKESHGFVNGIYGVG-NAGTAITSFLAPVIATSVGWRTTVQCYLVLLAA 170
Cdd:pfam07690 84 SLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGfGLGAALGPLLGGLLASLFGWRAAFLILAILSLL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 171 FALMNFLLGDRKEKKVNTP-------LMEQIKGVYKNEKLWFLCIFyFLTFGSFVAFTVYLPnFLVSHFGLDKVDAGMRT 243
Cdd:pfam07690 164 AAVLLLLPRPPPESKRPKPaeearlsLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLP-LYQEVLGLSALLAGLLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 244 AGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMP---SMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFS 320
Cdd:pfam07690 242 GLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSltlSSLWLLLALLLLGFGFGLVFPALNALVSDLAP 321
|
330 340
....*....|....*....|...
gi 1020085945 321 -EQAGIVNGLVSALGGLGGFFPP 342
Cdd:pfam07690 322 kEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
39-373 |
4.39e-21 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 93.38 E-value: 4.39e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 39 TAGQISMVTAVPVILGSVlriPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFVGI-GGAVFSVGVTS 117
Cdd:cd17324 35 QAGLLVSAYALGYALGAL---LLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLaHGGFWAIAAAY 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 118 LPKYFPKESHGFVNGIYGVGNA-GTAITSFLAPVIATSVGWRTTVQCY--LVLLAAFALMNFLLGDRKEKKVNTPLMEQI 194
Cdd:cd17324 112 AADLVPPEKRGRAIGLVFSGLTlGLVLGRPLGGLLGQLLGWRAAFLAIavLALLAALLLWRLLPSLPPKKPGSLGLLSSL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 195 KGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFnPFKILIFVF 274
Cdd:cd17324 192 LLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRG-GRRALLIAL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 275 IGLTLSGIILSFM-PSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFSEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTG 353
Cdd:cd17324 271 LLLAAALLLLTLLgPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGG 350
|
330 340
....*....|....*....|
gi 1020085945 354 HYAIGFMALSEVALACLIIT 373
Cdd:cd17324 351 WAGVGWVGAALLLLALLLAL 370
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
19-374 |
5.77e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 93.26 E-value: 5.77e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 19 FMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLI 98
Cdd:cd06174 9 GLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 99 IGGLFVGIGGAVFSVGVTSL-PKYFPKESHGFVNGIY-GVGNAGTAITSFLAPVIATSVGWRTTVQCY---LVLLAAFAL 173
Cdd:cd06174 89 LGRFLLGLGSGLIDPAVLALiADLFPERERGRALGLLqAFGSVGGILGPLLGGILASSLGFGWRAVFLiaaALALLAAIL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 174 MNFLLGDRKEKKVN-------TPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGF 246
Cdd:cd06174 169 LLLVVPDPPESARAkneeassKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLF 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 247 IVLATIMRPIGGWLGDK-FNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFS-EQAG 324
Cdd:cd06174 249 GLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPpEIRG 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1020085945 325 IVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITV 374
Cdd:cd06174 329 TAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
15-377 |
9.41e-21 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 92.64 E-value: 9.41e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 15 LVIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSM 94
Cdd:cd17325 5 LFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 95 MDLIIGGLFVGIGGAVFSVGVTSL-PKYFPKESHGFVNGIYGVGN-AGTAITSFLAPVIATSVGWRTT-VQCYLVLLAAF 171
Cdd:cd17325 85 WQLLLARFLQGLASAAVWPAAMALiADIAPPEERGRAMGIFSSAIgLGFLIGPLLGGLLADALGYRAPfLVCAALALLAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 172 ALMNFLLGDRKEKKVNTPLMEQ-----IKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGF 246
Cdd:cd17325 165 VLALLLLPEPRPPPNKRAVSAArlrsgLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQ 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 247 IVLATIMRPIGGWLGDKFNPFKILIfvfIGLTLSGIILSFMPSMNVYTFgCLLVAFCAGIGNGTIFKLVPMYFSEQA--- 323
Cdd:cd17325 245 GLASALSQPPAGKLSDRIGRKPLIL---IGLLLSAVALLLLPLATSFWL-LLLLLALLGLGLGLVFPATLALLADIVppe 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1020085945 324 --GIVNGLVSALGGLGGFFPPLILTLLFQLTGhYAIGFMALSEVALACLIITVWMY 377
Cdd:cd17325 321 grGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVLFLLLR 375
|
|
| PRK15034 |
PRK15034 |
nitrate/nitrite transport protein NarU; Provisional |
8-381 |
1.58e-19 |
|
nitrate/nitrite transport protein NarU; Provisional
Pssm-ID: 184994 [Multi-domain] Cd Length: 462 Bit Score: 89.94 E-value: 1.58e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 8 LSLQTSNLVIGFMVWVILSSLMPYI-KADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVF 86
Cdd:PRK15034 36 LWISVSCLLLAFCVWMLFSAVTVNLnKIGFNFTTDQLFLLTALPSVSGALLRVPYSFMVPIFGGRRWTVFSTAILIIPCV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 87 YISVA-----NSMMDLIIGGLFVGIGGAVFSVGVTSLPKYFPKESHGFVNGIY-GVGNAGTAITSFLAPVIA-------- 152
Cdd:PRK15034 116 WLGIAvqnpnTPFGIFIVIALLCGFAGANFASSMGNISFFFPKAKQGSALGINgGLGNLGVSVMQLVAPLVIfvpvfafl 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 153 ---------------TSVGWRTTVQCYLVLLAAFALMNFLLGDRKEKKVNTPLMEQIkgvykneKLWFLCIFYFLTFGSF 217
Cdd:PRK15034 196 gvngvpqadgsvmslANAAWIWVPLLAIATIAAWSGMNDIASSRASIADQLPVLQRL-------HLWLLSLLYLATFGSF 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 218 VAFTVYLPNFLVSHFGldkvDAGMRTAGFI--VLATIMRPIGGWLGDKFNPFKILIFVFIGLTL-SGIILSFMPSMNVYT 294
Cdd:PRK15034 269 IGFSAGFAMLAKTQFP----DVNILRLAFFgpFIGAIARSVGGAISDKFGGVRVTLINFIFMAIfSALLFLTLPGTGSGN 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 295 FGCLLVAF-----CAGIGNGTIFKLVPMYF--------------SEQA--------GIVNGLVSALGGLGGFFPPLILTL 347
Cdd:PRK15034 345 FIAFYAVFmglflTAGLGSGSTFQMIAVIFrqitiyrvkmkggsDEQAqreavtetAAALGFISAIGAVGGFFIPQAFGM 424
|
410 420 430
....*....|....*....|....*....|....
gi 1020085945 348 LFQLTGHYAIGFMALSEVALACLIITVWMYSQEK 381
Cdd:PRK15034 425 SLNMTGSPVGAMKVFLIFYIVCVLLTWLVYGRRK 458
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
28-373 |
6.12e-18 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 84.60 E-value: 6.12e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 28 LMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFVGIG 107
Cdd:cd17475 18 LAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 108 GAVF-SVGVTSLPKYFPKESHGFVNGIYGVG-NAGTAITSFLAPVIATSVGWRTTVQCYLVLLAAFALMNFLL------G 179
Cdd:cd17475 98 YGSVqPGGGRAIMRWFPPRERGLAMGIRQTGvPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFyreppaA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 180 DRKEKKVNTPLMEqIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGW 259
Cdd:cd17475 178 SAATESASTLLRS-LKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 260 LGDKFNP---FKILIFVFIGLTLSGIILSFMPSmnvYTFGCLLVAFCAGIG------NGTIFKLVP-MYFSEQAGIVNGL 329
Cdd:cd17475 257 VSDRVFGgrrRPVLVITAAIAAAALLVLSLLSP---GTPLWLLVLLLILLGlfaigwNGLYLTLVAeSAGPEQAGTALGL 333
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1020085945 330 VSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIIT 373
Cdd:cd17475 334 ANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
23-376 |
1.10e-17 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 83.78 E-value: 1.10e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 23 VILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFyISVANSMMDLIIGGL 102
Cdd:cd17339 16 TSVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGIL-LRSLGGIALLFLGTA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 103 FVGIGGAVFSVGVTSLPK-YFPKEShGFVNGIYGVG-NAGTAITSFLAPVIATSV--GWRTTVQCyLVLLAAFALMNFLL 178
Cdd:cd17339 95 LAGAGIAVGNVLLPSLIKrDFPRRV-GLMTGLYTTSmNLGAALASGLSVPLAQALggGWRGALAI-WALPALLALLIWLP 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 179 GDRKEKKVNTPLMEQIKG-VYKNEKLWFLCIFYFLTfgSFVAFTV--YLPNFLVSHfGLDKVDAGMRTAGFIVLATIMRP 255
Cdd:cd17339 173 QLRRRKRAAAAAAPLTKIsVWRSPLAWQVTLFMGLQ--SLLFYTLmaWLPTILIDA-GLSAATAGWLLSLFQLVGIPASL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 256 IGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVafcaGIGNGTIFKLVPMYFS------EQAGIVNGL 329
Cdd:cd17339 250 LVPILATRLKNQRPIVVLLAVLFIIGVLGLLFAPTALALLWAVLL----GLGGGAAFSLALTLISlrssdpAEAAALSGM 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1020085945 330 VSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITVWM 376
Cdd:cd17339 326 AQSVGYLLAALGPLLFGVLHDLTGSWTAPLVLLLALTVLQLVAGLGA 372
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
24-312 |
1.36e-17 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 83.39 E-value: 1.36e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 24 ILSSLMPYIKADIPLTAGQISMVTAVpVILGSVLRIPI-GYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGL 102
Cdd:cd17503 14 IVNVALPTIMGDLGASLDTVQWVITS-YLLALAIMIPLsGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 103 FVGIGGAV-FSVGVTSLPKYFPKESHGFVNGIYGVGNA-GTAITSFLAPVIATSVGWRTtvqCYLVLLAaFALMNFLLGd 180
Cdd:cd17503 93 LQGFGGGVlIPLAQTILLRIYPPEKRGAAMGLVGLVILlAPAIGPTLGGWLTDNLSWRW---IFYINLP-IGILALLLA- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 181 rkekkvntPLMEQikGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWL 260
Cdd:cd17503 168 --------PLLDL--RLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRL 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1020085945 261 GDKFNPFKILIFVFIGLTLSGIILSFM-PSMNVYTFGCLLvaFCAGIGNGTIF 312
Cdd:cd17503 238 LDKFGPRLLLLAGLLLLALGTLLLAFLtPDTSLWLIILPL--FIRGLGMGLVF 288
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
16-375 |
4.91e-17 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 81.49 E-value: 4.91e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 16 VIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMM 95
Cdd:cd17489 6 FFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 96 DLIIGGLFVGIG-GAVFSVGVTSLPKYFPKESHGFVNGIYGVGNA-GTAITSFLAPVIATSVGWRTTVQCYLVLLAAFAL 173
Cdd:cd17489 86 LLLVLRLIHGIGwGAFTTAAATLVADIIPPSRRGEGIGYYGLATTlAMALGPALGLFLYQHLGFAVLFIVAAVLALLALL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 174 MNFLLGDRKEKKVNTPLMEQI-KGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGldkVDAGMRTAGFIVLATI 252
Cdd:cd17489 166 LVFLVKDPPPVAAEEAEAGTRaFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGI---SNAGLFFTVYAIALLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 253 MRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYtfgcLLVAFCAGIGNGTIF--------KLVPmyfSEQAG 324
Cdd:cd17489 243 SRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWML----LLAAVLYGLGFGLLFpalqalavDLVP---PHRRG 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1020085945 325 IVNGLVSALGGLGGFFPPLILTLLFQLTGhYAIGFMALSEVALACLIITVW 375
Cdd:cd17489 316 AANGTFFIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLALVLYIF 365
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
19-374 |
2.32e-15 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 76.49 E-value: 2.32e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 19 FMVWVILSSLMPYIKADIP--LTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMD 96
Cdd:cd17316 12 AYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPIL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 97 LIIGGLFVGIG-GAVFSVGVTSLPKYFPKESHGFVNGIYGVGNA-----GTAITSFLAPVIATSVGWRTtvqcYLVLLAA 170
Cdd:cd17316 92 LLVLRFLQGIGiGGEYPGASTYVAEFAPSKRRGFALGLLQSGWAlgallAALVASLLIPLLSGDWGWRI----LFLIGAL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 171 FALMNFLLGDRkekkvntplmeqikgvyknekLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLA 250
Cdd:cd17316 168 PALLALLLRRR---------------------TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 251 TIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYT--FGCLLVAFCAGIGNGTIFKLVPMYF-SEQAGIVN 327
Cdd:cd17316 227 LVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLllLLLFILSFFVGGVWGALYAYLAELFpTEVRATGV 306
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1020085945 328 GLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITV 374
Cdd:cd17316 307 GLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
16-376 |
1.06e-14 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 75.00 E-value: 1.06e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 16 VIGFMVWVILSSLMPYIK---ADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVAN 92
Cdd:cd17355 10 LILILSWGIRYYFGVFIIpiiAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 93 SMMDLIIGGLFVGIGGAVFSVGV--TSLPKYFPKESHGFVngiYGVGNAGTAITSFL-APVIATSV---GWRTTVQCY-- 164
Cdd:cd17355 90 SLWQLYLLWGLLGGGGAGTLAAVafATVAAWWFERRRGLA---LGILTAGGGLGSLVfLPLGAALIeafGWRTALLVLal 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 165 LVLLAAFALMNFLLGDRKEKKV-------NTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHfGLDKV 237
Cdd:cd17355 167 LALLVLVPVLLLLRRRPADLALrayddasPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADR-GISPA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 238 DAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSF--MPSMNVYTFGCLLVAFCAGIGNGTIFKLV 315
Cdd:cd17355 246 AAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLlpFPPLALLLFAALFGLGWGATVPLTAALAA 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1020085945 316 PMYFSEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFmALSEVALACLIITVWM 376
Cdd:cd17355 326 RYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAW-ALAVALGLIAALLVLP 385
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
24-344 |
1.08e-14 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 74.51 E-value: 1.08e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 24 ILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLF 103
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 104 VGIGGAVFSVGVTSLPKYFPKESHGFVNGIYGV-GNAGTAITSFLA-PVIATSVGWRTTVQCYLVLLAAFALMNFLLGDR 181
Cdd:cd17478 94 AGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVgGNLGFALGPLIAaALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 182 KEKKVNTPLMEQIKGVYKNE--KLWFLCIFYFLTFGSFVAFTVYLPNFLVSHfGLDKVDAGMRTAGFIVLATIMRPIGGW 259
Cdd:cd17478 174 KPEAKKAAAKSSARSTLKGVwrALLLLLIIVFLRSWVLSSLTTFLPFYLVQR-GYSLVFAGLLLSLFLFAGAIGTLIGGP 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 260 LGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYtfgclLVAFCAGIGNGTIFKLVPMY----FSEQAGIVNGLVSALG- 334
Cdd:cd17478 253 LSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSY-----ILLVLAGFLLFASFPVTVVLaqelLPGNVGLASGLMMGLSf 327
|
330
....*....|
gi 1020085945 335 GLGGFFPPLI 344
Cdd:cd17478 328 GLGGIGAPVL 337
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
25-353 |
1.12e-14 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 74.72 E-value: 1.12e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 25 LSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFV 104
Cdd:TIGR00881 14 FALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALN 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 105 GI-GGAVFSVGVTSLPKYFPKESHGFVNGIYGVGN--AGTAITSFLAPVIATSVGWRTTVQCYLVLLAAFALMNFLLG-- 179
Cdd:TIGR00881 94 GIfQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHnvGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLrd 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 180 -------------------DRKEKKVNTPLMEQIKGVY--KNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVD 238
Cdd:TIGR00881 174 spqscglppaeempneepdGDAEKKEEELTKKQIFLQYvlLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEK 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 239 AGMRTAGFIVLATIMRPIGGWLGDKF---NPFKILIFVFIGLTLSGIILSFMPSMNVYTFG-CLLVAFCAGIGNGTIFKL 314
Cdd:TIGR00881 254 ASWAFTLYELGGLVGTLLAGWLSDKLfngRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLiCLFALGFLVYGPQMLIGV 333
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1020085945 315 VPM--YFSEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTG 353
Cdd:TIGR00881 334 IASelAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
20-353 |
2.43e-14 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 74.17 E-value: 2.43e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 20 MVWVILSSLMPYIKADIP-LTAGQISMVTAVPVILGSVLRIPIGYWT----NRFGARKLFF--------ISFILLlFPVF 86
Cdd:COG2211 24 LAFGLLSAYLLYFYTDVLgLSAALVGLILLVARLWDAITDPLIGALSdrtrTRWGRRRPWIligaiplaLSFVLL-FTAP 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 87 YISVANSMMDLIIGGLFVGIGGAVFSVGVTSLP--KYFPKESHGFVNGI-YGVGNAGTAITSFLAPVIATSV------GW 157
Cdd:COG2211 103 DLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGaeLTPDYEERTRLSSWrFAFAGLGGLLASVLPPPLVAAFggdaalGY 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 158 RTTVQCYLVLLAAFALMNFLLGDRK--EKKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLD 235
Cdd:COG2211 183 RLTALIFAVLGLLAFLLTFFGTKERpvPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLS 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 236 KVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFgcLLVAFCAGIGNGTIFKLV 315
Cdd:COG2211 263 AALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLL--LVLAALAGIGLGAILVLP 340
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1020085945 316 PMYFSE------------QAGIVNGLVSALGGLGGFFPPLILTLLFQLTG 353
Cdd:COG2211 341 WAMLADvvdydewktgrrREGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
32-376 |
1.19e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 71.45 E-value: 1.19e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 32 IKADIPLTAGQISMVTAVP---VILGSVLripIGYWTNRFGARKLFFISfiLLLFPVFYIS--VANSMMDLIIGGLFVGI 106
Cdd:cd17473 26 AQHFVPNSELLVPLLLTLPalfIALFAPL---AGWLADRFGRKRLLIAG--LLLYGIGGVAglFLDSLYALLASRALLGI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 107 GGAVFSVGVTSL-PKYFPKESHGFVNGIYGVGNAGTAITSFLAPVIATSVGWRTTVQCYLVLLAAFALMNFLLGDRKEKK 185
Cdd:cd17473 101 GVAGIMTLATALiGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLALPVLILVLLFLPEPARKS 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 186 VNTPLM-EQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKF 264
Cdd:cd17473 181 KSAASPgAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 265 NPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGI----GNGTIFKLVPmyfSEQAGIVNGLVSALGGLGGFF 340
Cdd:cd17473 261 GKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLllptLNSWAMSLVP---PELRGRAMGIVTSAFFLGQFL 337
|
330 340 350
....*....|....*....|....*....|....*.
gi 1020085945 341 PPLILTLLFQLTGHYAIGFMALSEVALACLIITVWM 376
Cdd:cd17473 338 SPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
16-373 |
3.26e-13 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 70.29 E-value: 3.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 16 VIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMM 95
Cdd:cd17474 9 LLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 96 DLIIGGLFVGIGGAVF-SVGVTSLPKYFPKESHGFVNGIYGVGN-AGTAITSFLAPVIAtSVGWRTTVQCYLVL-LAAFA 172
Cdd:cd17474 89 LLLAGRALQGIGAAGLgPLALTLIGDLFEGGERAKAMGLYEAALgLGIAVGPLLGGLLA-AISWRYPFFLLAALiPVAFL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 173 LMNFLLGDRKEKKVNTPLMEQIKGVYKNEKLWFLCIFY--FLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLA 250
Cdd:cd17474 168 AILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVsaFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 251 TIMRPIGG-WLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFSEQA-GIVNG 328
Cdd:cd17474 248 ALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEErGTASS 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1020085945 329 LVSALGGLGGFFPPLILTLLFQLTGHYAIgFMALSEVALACLIIT 373
Cdd:cd17474 328 LYNFVRFLGQAVGPLLFGLLLEIFGLSAP-FLVGAAIALAAAVLL 371
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
15-377 |
9.20e-13 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 68.79 E-value: 9.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 15 LVIGFMVWVILSSLMPYIKADIPLTAGQISMVTavpVILGS------VLRIPIGYWTNRFGARKLF-FISFILLLFPVFY 87
Cdd:cd17490 2 LIIVFLFWFSQYVYVPFLSPYAESLGASLSMIG---IILGAygisqmLLRIPLGILSDRIGKRKLFiIIGLLFTVLASLI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 88 ISVANSMMDLIIGGLFVGIGGAVFSVGVTSLPKYFPKESHGFVNG-IYGVGNAGTAITSFLAPVIATSVGWRttVQCYLV 166
Cdd:cd17490 79 MILFPSPWGLLIARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGlINLVNNLGQLIAFLIGGLIAEHFGMR--APFLLA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 167 LLA---AFALMNFLLGDRKEKKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRT 243
Cdd:cd17490 157 ALAgvlGFILSLFIKEERREKKPVLTELKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 244 AGFIVLATIMRPIGGWL-GDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYtfgcLLVAFCAGIGNGTIFKLVpMYFS-- 320
Cdd:cd17490 237 IIYLLPNALASLLSGTLfYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLL----YLLQALNGFGTGILFPLL-MSLSie 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1020085945 321 ----EQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGhYAIGFMALSEVALACLIITVWMY 377
Cdd:cd17490 312 gvpaEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFG-LQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
26-372 |
2.43e-12 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 67.64 E-value: 2.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 26 SSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIG-GLFV 104
Cdd:cd17353 23 SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGyGVLG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 105 GIG-GAVFSVGVTSLPKYFPkESHGFVNGIY--GVGnAGTAITSFLAPVIATSVGWRTTvqcYLVLLAAFALMNFLLG-- 179
Cdd:cd17353 103 GIGaGIGYITPVSTAVKWFP-DKRGLATGIViaGFG-LGSLIFSPLIAYLINTVGVPTT---FLILGIIFLIIIVIGAfl 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 180 --------------DRKEKKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAG 245
Cdd:cd17353 178 irdppkgwvppgvdPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSI 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 246 FIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNV-YTFGCLLVAFCAGIGNGTIFKLVPMYFSE-QA 323
Cdd:cd17353 258 LSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVlFVLGVALIGFCYGGGFALFPALTADFFGTkNA 337
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1020085945 324 GIVNGLVSALGGLGGFFPPLILTLLfqltgHYAIGFMALSEVALACLII 372
Cdd:cd17353 338 GTNYGLLYTAKGVGGLIGPIIAAYV-----LYTGGYNAAFIIAAALSLV 381
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
39-372 |
5.56e-12 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 66.42 E-value: 5.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 39 TAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIG-GLFVGIG-GAVFSVGVT 116
Cdd:cd17352 36 STSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTyGVLGGLGlGLIYSPAIV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 117 SLPKYFPKEsHGFVNGIygvGNAGTAITSFLAPVIATS----VGWRTTVQ----CYLVLLAAFALMNFLlgdrkekkvnt 188
Cdd:cd17352 116 IVGQYFEKK-RGLATGI---AVAGSGVGTFVFPPLLRYlldnYGWRGALLilggLCLNLCVCGLLLRLL----------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 189 plmeqikgvyKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHfGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKfNPFK 268
Cdd:cd17352 181 ----------KDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSL-GIDESDAAFLLSIIGISDIVGRILLGLLADK-PRIG 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 269 ILIFVFIGLTLSGIILSFMPSMNVYT---FGCLLVAFCAGIGNGTIFKLVPMYFS-EQAGIVNGLVSALGGLGGFFPPLI 344
Cdd:cd17352 249 RLYLYIFTLLILGLSLLAFPLATTYVgliVFSVLFGFCSGSYSSLTPVILADLVGlEKLSNAYGLVLLFQGLAALVGPPI 328
|
330 340
....*....|....*....|....*...
gi 1020085945 345 LTLLFQLTGHYAIGFMALSEVALACLII 372
Cdd:cd17352 329 AGLLRDYTGDYDAAFYFCGACLLLSGVL 356
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
19-375 |
6.10e-12 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 66.87 E-value: 6.10e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 19 FMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLI 98
Cdd:PLN00028 49 FVSTFAAAPLLPIIRDNLNLTKSDIGNAGIASVSGSIFSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFI 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 99 IGGLFVGIGGAVFSVGVTSLPKYFPKESHGFVNGIY-GVGNAGTAITSFLAPVI---------ATSVGWRTtvqCYLV-- 166
Cdd:PLN00028 129 AVRFFIGFSLATFVSCQYWMSTMFNGKIVGTANGIAaGWGNLGGGVTQLLMPLVfplikdagaPSFTAWRI---AFFVpg 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 167 -LLAAFALMNFLLGD-------RKEKKVNTP----LMEQIKGVYKNEKLWFLCIFYFLTFGsfVAFTV--YLPNFLVSHF 232
Cdd:PLN00028 206 lLHIIMGILVLTLGQdlpdgnyRELKKSGTMpkdsFSKVLRYGVTNYRTWILALTYGYSFG--VELTMdnIIAEYFYDRF 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 233 GLDKVDAGMRTAGFIVLATIMRPIGGWLGDK-FNPFKI---LIFVFIGLTLSG---IILSFMPSMNVYTFGCLLVAFCAG 305
Cdd:PLN00028 284 GLSLETAGAIAASFGLMNLFARPAGGYLSDVaARRFGMrgrLWALWIVQTLGGvfcIWLGRANSLGAAIVVMILFSIFVQ 363
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 306 IGNGTIFKLVPMYFSEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITVW 375
Cdd:PLN00028 364 AACGATFGIVPFVSRRSLGVISGLTGAGGNVGAVLTQLLFFTGSSYSTETGISLMGVMIIACTLPVAFIH 433
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
37-379 |
6.29e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 63.40 E-value: 6.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 37 PLTAGQISMVTAVPVILGSVlriPIGYWTNRFGARKLFFISFIL-----LLFPVFYISVANSMMDLIIGGLFVGIGGAVF 111
Cdd:cd06173 33 ALLVGLVLAAFFLPFLLFSP---FAGVLADRFDRRRLLILADLLrallaAVLALLALLGSLSLWLLLVLAFLLGIASAFF 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 112 SVGVTS-LPKYFPKESHGFVNGIYGVGN-----AGTAITSFLAPVIATSVGWRTTVQCYLVLLAAFALMNFLLGDRKEKK 185
Cdd:cd06173 110 GPARQAlLPELVPKEQLVRANALNSLATqlariIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGES 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 186 VNTPLMEQIKG---VYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGD 262
Cdd:cd06173 190 SSLLLRDLREGlryLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSK 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 263 KFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFSEQ-AGIVNGLVSALGGLGGFFP 341
Cdd:cd06173 270 RRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDElRGRVFSVYNALNSGAMPLG 349
|
330 340 350
....*....|....*....|....*....|....*...
gi 1020085945 342 PLILTLLFQLTGHYAIGFMAlsevALACLIITVWMYSQ 379
Cdd:cd06173 350 ALLAGLLADALGLSAVFLLA----GALLLLAALLLLLL 383
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
19-349 |
7.18e-11 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 62.96 E-value: 7.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 19 FMVWV---ILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMM 95
Cdd:cd17321 6 FLAALdvtIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 96 DLIIGGLFVGIGGAVFSVGVTSLPK-YFPKESHGFVNGIYGVGNA-GTAITSFLAPVIATSVGWRTTvqcyLVLLAAFAL 173
Cdd:cd17321 86 FLIAARALQGIGAAAIMPASLALIAaTFPGERRGRALGLWGAVVGiGAALGPLLGGLLLELFGWRWI----FLINVPIGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 174 MNFLLGDRkekkvntplmeqikgvyknekLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIM 253
Cdd:cd17321 162 VALLLART---------------------FSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVA 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 254 RPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFgCLLVAFCAGIGNGTIFKLVPMYFS-----EQAGIVNG 328
Cdd:cd17321 221 APLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWL-LLPGLVLLGLGLGLFATPLTNAALssvpkEKAGAASG 299
|
330 340
....*....|....*....|.
gi 1020085945 329 LVSALGGLGGFFPPLILTLLF 349
Cdd:cd17321 300 ILNTARQLGGALGVALLGALL 320
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
203-376 |
3.80e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 60.65 E-value: 3.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 203 LWFLCIFYFLTFGSFVAFTVYLPnFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGI 282
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAP-PLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 283 ILSFMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFS-EQAGIVNGLVSALGGLGGFFPPLILTLLFQLTG-HYAIGFM 360
Cdd:COG2271 91 LFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPpKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGwRAAFLIL 170
|
170
....*....|....*.
gi 1020085945 361 ALseVALACLIITVWM 376
Cdd:COG2271 171 GL--PGLLLALLRFWL 184
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
59-350 |
9.00e-10 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 59.64 E-value: 9.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 59 IPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFVGIG-GAVFSVGVTSLPKYFPKESHGFVNGIYGVG 137
Cdd:cd17333 49 LLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGaGILDTGANTFVGALFEESSATRLNVLHGFF 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 138 NAGTAITSFLAPVIATSVGWRTT-------VQCYLVLLAAFALMNFLLGDRKEKKVNTPLMEQIKGVYKNEKLWFLCIFY 210
Cdd:cd17333 129 GLGALIGPLIATSLLTSELSWSWayliiglIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALAL 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 211 FLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSM 290
Cdd:cd17333 209 FLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTL 288
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 291 NVYTFGCLLVAFCAGIGNGTIFKLVPMYFSEQAGIVNGLVSALGGLGGFFPPLILTLLFQ 350
Cdd:cd17333 289 VVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAE 348
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
23-379 |
1.16e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 59.14 E-value: 1.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 23 VILSSLMPYIKADIPLTAGQISMVTA---VPVILGSVLripIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLII 99
Cdd:cd17365 16 AVMGFVAPALAQDWGLSPAQLGPVGSaalFGMAIGALL---AGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 100 GGLFVGIG-GAVFSVGVTSLPKYFPKESHGFVNGIYGVG-NAGTAITSFLAPVIATSVGWRTTVqcYLVLLAAFALMNFL 177
Cdd:cd17365 93 LRFLTGLGlGAAMPNAITLVSEYAPARRRSLAVTLMFCGyPLGAALGGFLAAALIPAFGWRSVF--LLGGVPPLILLPLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 178 LGDrkekkvntpLMeqikgvykneklwfLCIFYFLTFGSFVAFTVYLPNFLVSHfGLDKVDAGMRTAGFIVLATIMRPIG 257
Cdd:cd17365 171 RGT---------LL--------------LWVTFFMGLLLVYLLNSWLPKLMVEA-GYSLSQALTITLLLNIGGVIGSLLL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 258 GWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGIG-NGTIFKLVPMYFSEQA-GIVNGLVSALGG 335
Cdd:cd17365 227 GWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGaQVGLYALAARFYPTEVrATGVGWALGVGR 306
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1020085945 336 LGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITVWMYSQ 379
Cdd:cd17365 307 LGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVLLLRLR 350
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
203-376 |
4.26e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 57.68 E-value: 4.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 203 LWFLCIFYFLTFGSFVAFTVYLPnFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGI 282
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 283 ILSFMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFS-EQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGhYAIGFMA 361
Cdd:COG2814 91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WRWVFLV 169
|
170
....*....|....*
gi 1020085945 362 LSEVALACLIITVWM 376
Cdd:COG2814 170 NAVLALLALLLLLRL 184
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
181-375 |
3.26e-08 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 54.84 E-value: 3.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 181 RKEKKVNTPLMEQIKGVYKNekLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWL 260
Cdd:cd17369 210 EAGQVVRAPLVEVLRRHWRA--LLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 261 GDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFSEQAGIVN-----GLVSALGG 335
Cdd:cd17369 288 SDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVrytgaSLGYQLGA 367
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1020085945 336 -LGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITVW 375
Cdd:cd17369 368 iLGGGFAPLIATALVAATGSWWPVALYLAALAVISLVAALF 408
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
217-315 |
5.81e-08 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 54.22 E-value: 5.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 217 FVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTL-SGIILSFMPSMN--VY 293
Cdd:cd17367 239 FYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLaTVPLLSALDHTDspYT 318
|
90 100
....*....|....*....|..
gi 1020085945 294 TFGCLLVAFCAGIGNGTIFKLV 315
Cdd:cd17367 319 AFALVLVGLVFLSGYTSINAVV 340
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
25-372 |
6.23e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 53.82 E-value: 6.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 25 LSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSM----MDLIIG 100
Cdd:cd17312 22 FSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLwffaVLWGLN 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 101 GLFVGIGgavFSVGVTSLPKYFPKESHGFVNGIYGVG-NAGTAITSFLAPVIATSVGWRTTVQCYLVLLAAFALMNFLLg 179
Cdd:cd17312 102 GLFQSMG---WPPCVKLLGNWFSKKERGTVYGIWSTShNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFF- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 180 drkekkvntpLMEQIKGVykneklWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGW 259
Cdd:cd17312 178 ----------LRDSPPYV------WVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 260 LGDKF---NPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCL---------LVAFCAGIGNGTIFKlvpmyfSEQAGIVN 327
Cdd:cd17312 242 LSDKLfggRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLfligffvggPINLIGGAAAQDIGR------KEAAGTAT 315
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1020085945 328 GLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLII 372
Cdd:cd17312 316 GFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLL 360
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
29-373 |
8.25e-08 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 53.73 E-value: 8.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 29 MPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFVGIGG 108
Cdd:cd17320 22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 109 AVFSVGVTSLPK--YFPKESHgfvnGIYGVGNAGTAITSFLAPV----IATSVGWRT-----TVQCYLVLLAAFALMNFL 177
Cdd:cd17320 102 AAGSVVARAIVRdlYSGAELA----KIFSLLMMILAIAPALAPLlgglLLLFFGWRAifvflALLGLLLLLLVLLFLPET 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 178 LGDRKEKKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIG 257
Cdd:cd17320 178 LPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLN 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 258 GWLGDKFNPFKIL-----IFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFSEQAGIVNGLVSA 332
Cdd:cd17320 258 GRLVRRFGPRRLLrlgllLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGF 337
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1020085945 333 LGGLGGFFPPLILTLLFQLTGH-YAIGFMALSEVALACLIIT 373
Cdd:cd17320 338 LQFLIGALAGALVGLLPNGTALpMGLLILVLGLLALLLLILL 379
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
24-290 |
1.26e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 52.51 E-value: 1.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 24 ILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLF 103
Cdd:COG0477 32 IVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARAL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 104 VGIG-GAVFSVGVTSLPKYFPKESHGFVNGIYG-VGNAGTAITSFLAPVIATSVGWRttvqcyLVLLAAFALMNFLLGDR 181
Cdd:COG0477 112 QGIGaGGLMPGALALIAELFPARERGRALGLWGaAIGLGLALGPLLGGLLVAALGWR------WIFLINAPLGLLALVLR 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 182 KEKKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLG 261
Cdd:COG0477 186 LRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLL 265
|
250 260
....*....|....*....|....*....
gi 1020085945 262 DKFNPFKILIFVFIGLTLSGIILSFMPSM 290
Cdd:COG0477 266 LLLLLLLALLLALLLLLLLLLLLLLLALL 294
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
232-381 |
1.40e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 52.95 E-value: 1.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 232 FGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGIGNGTI 311
Cdd:COG2807 48 LGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLL 127
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1020085945 312 FKLVPMYFSEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTG-HYAIGFMALseVALACLIITVWMYSQEK 381
Cdd:COG2807 128 PGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGwRGALAVWAL--LALLALLLWLPLLRRRP 196
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
15-361 |
1.42e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 52.97 E-value: 1.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 15 LVIGFMVWVILSSLMPYI------KADIPLTAGQISMVTAVPVILGSVLripIGYWTNRFGARKLFFISFILLLFPVFYI 88
Cdd:cd17330 5 VFLDALGFGIVFPVLPFYvrefnkLGASGYYVGLLQSSYSLGQFLASPL---WGRLSDRYGRKPVLLLSLAGSAVSYVLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 89 SVANSMMDLIIGGLFVGIGGAVFSVGVTSLPKYFPKESHGFVNGIYGvgnAGTAITSFLAPVIATSVGWRTTVQCYLVLL 168
Cdd:cd17330 82 GLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIIS---AAFGLGFILGPALGGFLSTPYGYALPFLVA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 169 AAFALMNFLLGDRKEKKvntplmeqikgvyknekLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIV 248
Cdd:cd17330 159 AALALLNLVLVLFFLPP-----------------LRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGI 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 249 LATIMR-PIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYF-SEQAGIV 326
Cdd:cd17330 222 AGILAQlLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVpSKEQGKA 301
|
330 340 350
....*....|....*....|....*....|....*
gi 1020085945 327 NGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMA 361
Cdd:cd17330 302 QGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLA 336
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
21-374 |
2.85e-07 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 51.88 E-value: 2.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 21 VWVILSSLMPYIKADIPLTAGQIS-MVTAVPVilGSVLRIPI-GYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLI 98
Cdd:cd17393 14 LMASWATRIPAIKDRLGLSDAALGlLLLALGV--GALVAMPLaGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 99 IG----GLFVGIGGAVFSVGVTSLPKYFPKESHGFVNGIYGVGNAGTAITSFLAPVIATSVGWRTTVQCYLVLLAA-FAL 173
Cdd:cd17393 92 LAlflfGAANGALDVAMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLGAAAIGAGVSPGVHLLAAAVLLLLAAlVAI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 174 MNFLLGDRKEKKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIM 253
Cdd:cd17393 172 RALLPGTGEAAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTVG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 254 RPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVAFcaGIGNgtifkLVPMYFSE-------QAGIV 326
Cdd:cd17393 252 RLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGL--GLSV-----VVPLAFSAagalpglAAGIA 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1020085945 327 NGLVSALGGLGGFFPPLILTLLFQLTGhYAIGFMAlseVALACLIITV 374
Cdd:cd17393 325 VARVATLGYLGFLVGPPLIGFLADATG-LRTAFLV---VALLALLVAL 368
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
134-347 |
3.02e-07 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 52.22 E-value: 3.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 134 YGVGNAGTAITSFLAPVIATSVGWRTTVQCY------LVLLAAFALMNFLLG------DRKEKKVNTPLMEQIKGVYKNE 201
Cdd:cd17332 142 MFFATIGGLLVTVLPPPLVAYFGGGNASRGYfltaliIGIIGIILLLICFFGtrervvPPEEEKSKLPLLKSLKALLKNR 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 202 KLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAgFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSG 281
Cdd:cd17332 222 PFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLL-ILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGL 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 282 IILSFMPSMNVYTFgcLLVAFCAGIGNGTIFKLVPMYFSE------------QAGIVNGLVSAL----GGLGGFFPPLIL 345
Cdd:cd17332 301 LLLFFLPPGNLVLI--LVLAVLAGIGYGGANLLPWAMLADvidygelktgkrREGIFYSVMTFFrklgLALAGALVGLIL 378
|
..
gi 1020085945 346 TL 347
Cdd:cd17332 379 SL 380
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
25-376 |
3.21e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 51.81 E-value: 3.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 25 LSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFV 104
Cdd:cd17504 15 LSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 105 GIGGAVFSVGVTSLPKYFPKESHGFVNGIY-GVGNAGTAITSFLAPVIATSVGWRTTVQCYLVLLAAFALMNFLLgDRKE 183
Cdd:cd17504 95 GIGGAVFPLAFALVREEFPPERVPVAQGILsATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLI-DLRL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 184 KKVNTPLMEQIKGVykneklwflcIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDK 263
Cdd:cd17504 174 LRRRNVLLANITAL----------LAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIAR 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 264 FNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVafcAGIGNGTIFKLVP--MYFS---EQAGIVNGLVSALGGLGG 338
Cdd:cd17504 244 VGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLL---IGIGLGLAFASLPniVVESvppDRTGIATGMNTVLRTIGS 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1020085945 339 FFPPLILTLLFQL------------TGHYAIGFMALSEVALACLIITVWM 376
Cdd:cd17504 321 AIGPAIAGAILTTytvsitsggvptEGAYVLAFLIGAALALAALLLSLLI 370
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-184 |
5.23e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.02 E-value: 5.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 13 SNLVIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARK---LFFISFILLLFPVFYIS 89
Cdd:COG2271 188 AYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklvLAIGLLLAALALLLLAL 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 90 VANSMMDLIIGGLFVGIGGAVFSVGVTSLPKYFPKESHGFVNGI-YGVGNAGTAITSFLAPVIATSVGWRTTVQCYLVLL 168
Cdd:COG2271 268 LPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLvNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALA 347
|
170
....*....|....*.
gi 1020085945 169 AAFALMNFLLGDRKEK 184
Cdd:COG2271 348 LLAALLALLLLRETRK 363
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
24-374 |
5.88e-07 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 51.07 E-value: 5.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 24 ILSSLMPYIK---ADIPLTAGQISMVTAVPVILGSVLripIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIG 100
Cdd:cd17331 18 LQQPVLPYLTkklGVDSVVFGYLQTTFSVLQLVGGPL---FGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 101 GLfVGIGGAVFSVGVTSLPKYFPKESH----GFVNGIYGVGnagTAITSFLAPVIATSVGWRTTVQCYLVLLAAFALMNF 176
Cdd:cd17331 95 RL-PSVFMHAMQAAQMVVTDLTDPGERaaalGRLGLSYGIG---MVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 177 LL---------GDRKEKKVNTPL---MEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTA 244
Cdd:cd17331 171 LLipsntkskrEKEAKESASPPSvfnLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMS 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 245 GFIVLATIMRPIG-GWLGDKFNPFKILIFVFIGLTLSGIILSFMPSmnVYTFGCLLVAFCAG------IGNGTIFKLVPm 317
Cdd:cd17331 251 YAGVLGMVVQGLLvGPLTKRFGERSLLKLSVALLAIGYLLLAFVTT--VWQLLVLLLPLVIGgsvlytVITSLLTKAVP- 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1020085945 318 yfSEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITV 374
Cdd:cd17331 328 --PEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
206-375 |
7.88e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.49 E-value: 7.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 206 LCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILS 285
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 286 FMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFSEQA-GIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSE 364
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEErGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170
....*....|.
gi 1020085945 365 VALACLIITVW 375
Cdd:pfam07690 161 SLLAAVLLLLP 171
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
39-361 |
8.53e-07 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 50.47 E-value: 8.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 39 TAGQISMVTAVPVILGSvLRIPIG-YWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIG-GLFVGIGGA-VFSVGV 115
Cdd:cd17423 36 SAQRVSWITSIGLAVQQ-LASPVGsALSTRYGARPVVMLGGLLSSLGFLLASFATSLLHLYLCiGLLSGLGWAlVFAPTM 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 116 TSLPKYFPKE-SHGFVNGIYGVGNAGTAITSFLApVIATSVGWRTTvqcyLVLLAAFALMNFLLGdrkekKVNTPLMEQI 194
Cdd:cd17423 115 ATVSRYFSRRrSLATGLALTGVGLSSFALSPLFQ-LLLDTYAWRGA----LLLLSALSLHLVPCG-----ALLRPLALPG 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 195 KGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNF----------LVSH---FGLDKVDAGMRTAGFIVLATIMRPIGGWLG 261
Cdd:cd17423 185 DPPAPPRSLSAAFGLSLLTHRAFLRYALATTLIntgyfipyvhLVAHaraLGLGEYQAAFVVSVAAVADAVGRLFSGWLA 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 262 DKfNPFKILIFVFIGLTLSGIILSFMPSMNVYT---FGCLLVAFCAGigngtifKLVPMYFSEQAGIVN--------GLV 330
Cdd:cd17423 265 DL-GPLRLLHLLVLWTALTGLSLLLLPLAKVYGsllALAVAYGFCAG-------ALAPLVFSVLPELVGvervlnatGLL 336
|
330 340 350
....*....|....*....|....*....|.
gi 1020085945 331 SALGGLGGFFPPLILTLLFQLTGHYAIGFMA 361
Cdd:cd17423 337 QMIESVGGLLGPPLSGWLRDITGDYTASFLV 367
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
12-377 |
1.35e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 49.92 E-value: 1.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 12 TSNLVIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVA 91
Cdd:cd17329 6 IGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 92 NSMMDLIIGGLFVGIGGAVFSVGVTSLPKYFPKESHG--FVNGIYGVGNAGTAITSFLAPVIATSVGWRTTVQCYLVLLA 169
Cdd:cd17329 86 HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRtrAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 170 AFALMNFLLGDRKEKKVNTPLMEQIKG---VYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGL-DKVDAGMRTAG 245
Cdd:cd17329 166 AALVLLFLLPETRPKRRAAEKTEILRGykiVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLgESLLGLLLALN 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 246 FIVLATIMRPIGGWLGdKFNPFKILIF-------VFIGLTLSGIILSFMPSMNVYTFGCLLVafcAGIGNGTIFKLVPmy 318
Cdd:cd17329 246 ALLIVLLQFPVARLVE-RFRLRKILMIgillfaiGFAVLAFANTLAVLILAMIVLTLGEMLV---FPAVQTLVAALAP-- 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1020085945 319 fSEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGhYAIGFMALSEVALACLIITVWMY 377
Cdd:cd17329 320 -PDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLG-PGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
66-312 |
2.11e-06 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 49.10 E-value: 2.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 66 NRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFVGIGGAVFSVGVTSLPKY-FPKESH----GFVNGIYGVgnaG 140
Cdd:cd17502 55 DLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADlVPPRERgkyqGYIGAVFGI---A 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 141 TAITSFLAPVIATSVGWRTtvqCYLVLLAAFALMNFLLgdrkekkvntplmeqikgvyknEKLWFLCIFYFLTFGSFVAF 220
Cdd:cd17502 132 SVAGPLIGGAFTDHLSWRW---CFYINLPIGGLALALL----------------------RTILLSSIFGFLFGGALFGL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 221 TVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLV 300
Cdd:cd17502 187 IYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIGTILMSVGAGLLTTLTLDTSKWLLIGY 266
|
250
....*....|..
gi 1020085945 301 AFCAGIGNGTIF 312
Cdd:cd17502 267 LILLGLGLGIGF 278
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
37-368 |
4.69e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 48.32 E-value: 4.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 37 PLTAGQISMVTAVPVILGSVLripIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFVGIGGAVFSVGV- 115
Cdd:cd17477 30 TALIGLVASAYYLGILLGSPL---VPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSe 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 116 TSLPKYFPKESHGFVNGIYGVGNAGTAITSFLAPVIATSVGWRTTVQCYLVLLAAFALMNFLLGDRKEKKVNTPLmeQIK 195
Cdd:cd17477 107 SWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEEAESI--SLR 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 196 GVYKNEKLWFLCIFYF-LTFGSFVAFtvyLPNFLVSHfGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVF 274
Cdd:cd17477 185 RLLRIAPLALLGAFVAgFLEGAFYSL---LPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCA 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 275 IGLTLSGIILSFMPSmnvYTFGCLLVAFCAGIGNGTIFKLVPMYFSEQAG-----IVNGLVSALGGLGGFFPPLILTLLF 349
Cdd:cd17477 261 LLGALAALLLPLVPG---LPLALLVLLFLWGGAAGPLYTLALALAGDRLPgdelvAANAALLLLYGLGSVIGPLLAGALM 337
|
330
....*....|....*....
gi 1020085945 350 QLTGHYAIgFMALSEVALA 368
Cdd:cd17477 338 DAFGPHGL-FLFLAAVALL 355
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
23-344 |
4.95e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 48.12 E-value: 4.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 23 VILSSLMPYIKADI---PLTAGQISMVTAVPVILGSVLripIGYWTNRFGARKLFFISfiLLLFPVFYI--SVANSMMDL 97
Cdd:TIGR00895 34 AAMGFAAPAISAEWgldPVQLGFLFSAGLIGMAFGALF---FGPLADRIGRRRVLLWS--ILLFSVFTLlcALATNVTQL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 98 IIGGLFVGIG-GAVFSVGVTSLPKYFPKESHGFVNGIYGVG-NAGTAITSFLAPVIATSVGWRTT--VQCYLVLLAAFAL 173
Cdd:TIGR00895 109 LILRFLAGLGlGGLMPNLNALVSEYAPKRFRGTAVGLMFCGyPIGAAVGGFLAGWLIPVFGWRSLfyVGGIAPLLLLLLL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 174 MNFL------LGDRKEKKVNTPLMEQI--------------KGVYKNEKLWFLCIF--------------YFLTFGSFVA 219
Cdd:TIGR00895 189 MRFLpesidfLVSKRPETVRRIVNAIApqmqaeaqsalpeqKSTQGTKRSVFKALFqgktaritvllwllYFMLLVGVYF 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 220 FTVYLPnFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLL 299
Cdd:TIGR00895 269 LTNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAI 347
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1020085945 300 VAFCAGIGNGTIFKLVPMYFSEQA-GIVNGLVSALGGLGGFFPPLI 344
Cdd:TIGR00895 348 AGFFVNGGQSGLYALMALFYPTAIrATGVGWAIGIGRLGAIIGPIL 393
|
|
| MFS_LacY |
cd06172 |
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY ... |
19-232 |
6.73e-06 |
|
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY proton/sugar family (also called LacY/RafB family) symporters are integral membrane proteins responsible for the transport of specific beta-glucosides into the cell accompanied by the import of a proton. Members include lactose permease (LacY), raffinose permease (RafB), and sucrose permease, which facilitate the transport of beta-galactosides, raffinose, and sucrose, respectively. The prototypical member, LacY, contains 12 transmembrane helices connected by hydrophilic loops with both N and C termini on the cytoplasmic face. The LacY/RafB permease family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340862 [Multi-domain] Cd Length: 389 Bit Score: 47.61 E-value: 6.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 19 FMVWVILSSLMP-YIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARK--LFFISFILLLFPVFYISV----- 90
Cdd:cd06172 12 FFIWSASFSFFPiWLTQINHLSGSETGIVFSANSLFALLFQPVYGLISDKLGLKKhlLWFISGLLVLFGPFFIFVygpll 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 91 -ANSMMDLIIGGLFVGiggAVFSVGVTSLPKYFPKES--HGFVNG-IYGVGNAGTAITSFLAPVIATsvgWRTTVQCYLV 166
Cdd:cd06172 92 qSNILLGAIVGGIYLG---FAFLAGCGAIESYIERVSrrFNFEYGrARMWGSLGWALAAFFAGILFN---INPNINFWLG 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1020085945 167 LLAAFALMNFLLGDRKE---------KKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVSHF 232
Cdd:cd06172 166 SGFALILLLLLLFAKPEdsdtaaaagANASSVSLKDVLELFRMPKFWFFILFVIGVSCFYDVFDQQFPPYFTSLF 240
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
27-177 |
1.04e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 47.15 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 27 SLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFVGI 106
Cdd:cd17370 220 AFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGL 299
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1020085945 107 G-GAVFSVGVTSLPKYFPKESHGFVngiYGVGNAGTAITSFLAPVIA----TSVGWRTTVqCYLVLLAAFALMNFL 177
Cdd:cd17370 300 YmGAQESIERAAVADLVPAELRGTA---YGLFNTVVGIGWLLASLIAgylwDLISPSAAF-LFSAVLALIALLLLL 371
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
220-380 |
1.22e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 46.99 E-value: 1.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 220 FTVYLPnFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPfkiLIFVFIGLTLSGIILSFMPSMNVYTFGCLL 299
Cdd:TIGR00881 14 FALAMP-YLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNP---RVFLPIGLILCAIVNLFFGFSTSLWVMAAL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 300 VAFCA---GIGNGTIFKLVPMYFSE-QAGIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIITVW 375
Cdd:TIGR00881 90 WALNGifqGMGWPPCGRTVTKWFSRsERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFL 169
|
....*
gi 1020085945 376 MYSQE 380
Cdd:TIGR00881 170 LLRDS 174
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
14-174 |
1.79e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.44 E-value: 1.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 14 NLVIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFIL---LLFPVFYISV 90
Cdd:cd17316 186 WFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILsgiLALPLFYLLS 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 91 ANSMMDLIIGGLFVGIGGAVFSVGVTSLPKYFPKESHGFVNGI-YGVGNAGTAITSFLAPVIATSVGWRTTVQCYLVLLA 169
Cdd:cd17316 266 GSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLsYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLA 345
|
....*
gi 1020085945 170 AFALM 174
Cdd:cd17316 346 IVALI 350
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
203-349 |
3.12e-05 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 45.37 E-value: 3.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 203 LWFLCIFYFLTFGSFVAFTVYLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKilifVFIGLTLSGI 282
Cdd:TIGR00886 3 LFFSWFGFFLSFLVWFAFSPLAVFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRY----TTALSLLLLA 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1020085945 283 ILSFMPSMNVYTF-GCLLVAFCAGIGNGTIFKLVPM----YFSEQAGIVNGLVSALGGLGG-----FFPPLILTLLF 349
Cdd:TIGR00886 79 IPCLWAGLAVQSYsVLLLIRLFIGIAGGSFASCMPWisffFPKKIQGTALGLAAGWGNMGGgvaqfVMPPIIGSLIF 155
|
|
| MFS_FucP_like |
cd17394 |
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ... |
164-343 |
3.37e-05 |
|
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340952 [Multi-domain] Cd Length: 401 Bit Score: 45.68 E-value: 3.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 164 YLVLLAAFALMNFLLGDRKEKKVNTPLME------QIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVS-HFGLDK 236
Cdd:cd17394 184 YLGIALVLLLLAVLILLSKLPEIEAAEAEalgskgTLLRLLKNPHLRLGVLAIFFYVGAEVAIWSFLINYLMEyIAGLTE 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 237 VDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKIL-IFVFIGLTLSGIILSFMPSMNVYTFgcLLVAFCAGIGNGTIFKLV 315
Cdd:cd17394 264 TSAATFVSYYWGGFMVGRFLGTALLKKISPKKLLaVFALLGLLLLLGAIFTGGMVALYAL--VLVGFFNSIMFPTIFSLA 341
|
170 180
....*....|....*....|....*....
gi 1020085945 316 PMYFSEQAGIVNG-LVSALGGlGGFFPPL 343
Cdd:cd17394 342 LKGLGKHTKTGSGlLVMAIVG-GAVVPLI 369
|
|
| cynX |
PRK09705 |
putative cyanate transporter; Provisional |
28-373 |
3.45e-05 |
|
putative cyanate transporter; Provisional
Pssm-ID: 236614 [Multi-domain] Cd Length: 393 Bit Score: 45.57 E-value: 3.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 28 LMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFVGIG 107
Cdd:PRK09705 31 LLPQLRQASGMSFSVAALLTALPVVTMGGLALAGSWLHQHVSERRSVAISLLLIAVGALMRELYPQSALLLSSALLGGVG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 108 GAVFSVGVTSLPKYFPKESHGFVNGIY-----GVGNAGTAITSFLAPVIATsvgWRTTVQCYlVLLAAFALMNFLLGDRK 182
Cdd:PRK09705 111 IGIIQAVMPSVIKRRFQQRTPLVMGLWsaalmGGGGLGAAITPWLVQHSET---WYQTLAWW-ALPAVVALFAWWWQSAR 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 183 EKKVNTPLMEQIKGVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVsHFGldkvDAGMRTAGFIVLATIMRPIGGWL-- 260
Cdd:PRK09705 187 EVASSHKTTTTPVRVVFTPRAWTLGVYFGLINGGYASLIAWLPAFYI-EIG----ASAQYSGSLLALMTLGQAAGALLmp 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 261 -GDKFNPFKILIFVFIGLTLSGII-LSFMPSmnvyTFGCLLVAFCaGIGNGTIFKL---VPMYFSEQAGIVNGLVSALGG 335
Cdd:PRK09705 262 aMARHQDRRKLLMLALVLQLVGFCgFIWLPL----QLPVLWAMVC-GLGLGGAFPLcllLALDHSVQPAIAGKLVAFMQG 336
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1020085945 336 LGGFFP---PLILTLLFQLTGHYAIGFMALSEVALACLIIT 373
Cdd:PRK09705 337 IGFIIAglaPWFSGVLRSISGNYLMDWAFHALCVVGLMIIT 377
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
24-137 |
3.59e-05 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 45.83 E-value: 3.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 24 ILSSLMPYIKADIPLTAGQISMVTAvPVILGSVLRIPIGYW-TNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGL 102
Cdd:TIGR00711 20 IVNVAIPTIAGDLGSSLSQVQWVIT-SYMLANAISIPLTGWlAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRV 98
|
90 100 110
....*....|....*....|....*....|....*.
gi 1020085945 103 FVGI-GGAVFSVGVTSLPKYFPKESHGFVNGIYGVG 137
Cdd:TIGR00711 99 IQGFgGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLT 134
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
20-178 |
1.36e-04 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 43.68 E-value: 1.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 20 MVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLII 99
Cdd:cd17372 13 MEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLII 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 100 GGLFVGIGGAVFSVGVTSLPKYFPKESHGFVNGIYGV-GNAGTAITSFLAPVIATSVGWRttvqcYLVLLAAFALMNFLL 178
Cdd:cd17372 93 LRCLVGLGLGGGPQLASWYLEFLPAKSRGTWMVLFSVfWTVGTIFEASLAWLVMPRLGWR-----WLLAFSSVPSSLLLV 167
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
18-178 |
1.38e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 43.77 E-value: 1.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 18 GFMVWVILSSLMPYIKADIPlTAGQISMVTAVPVILGSVLRIPIGYWTNRFGaRKLFFISFILLLFPVFYI-SVANSMMD 96
Cdd:cd06179 10 QLFGVTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFG-RRWFFIGGNLLGVVGSIVaGTAKSVNM 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 97 LIIGGLFVGIGGAVFSVGVTSLPKYFPKESHGFVNGIYgvgNAGTAITSFLAPVIATSV------GWRTtvqCYLVLLAA 170
Cdd:cd06179 88 LIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVV---NLVASPGSALGPLIAGALveanaaGWRW---IFYINAIF 161
|
....*...
gi 1020085945 171 FALMNFLL 178
Cdd:cd06179 162 NALALILL 169
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
206-381 |
1.39e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 43.57 E-value: 1.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 206 LCIFYFLTFGSFVAFTVYLPNFLVShFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILS 285
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQS-FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 286 FMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFSE-QAGIVNGLVSALGGLGGFFPPLILTLLF-QLTGHYAIGFMALS 363
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPErERGRALGLLQAFGSVGGILGPLLGGILAsSLGFGWRAVFLIAA 159
|
170
....*....|....*...
gi 1020085945 364 EVALACLIITVWMYSQEK 381
Cdd:cd06174 160 ALALLAAILLLLVVPDPP 177
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
23-362 |
3.09e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 42.45 E-value: 3.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 23 VILSSLMP-YIKADIPLTAGQ-----ISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFilllfpvFYISVANSMM- 95
Cdd:COG2270 28 VITTFVFPpYFTSVAALGDPAaatalWGYALAIAGLLVALLAPVLGAIADRSGRKKPFLAFF-------TLLGVLATAAl 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 96 ------DLIIGGLFVGIGGAVFSVGVTS----LPKYFPKESHGFVNGI-YGVGNAGTAITSFLAPVIATSVGWRTTVQCY 164
Cdd:COG2270 101 ffvapgGLWLGLLLFVLANIGFEGSLVFynafLPDIATPEEIGRVSGLgWALGYLGGVLLLLINLALFLKPEAFGLPDAG 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 165 L----------VLLAAFAL-MNFLLGDRKEKKVNTPL------MEQIKGVYKNEK-----LWFLCIFYFLTFGSFVAFTv 222
Cdd:COG2270 181 EavrisflltaLWWLLFALpLFLFLPERPRPGPAPPRgavragFRELRRTLRELRryrdlLRFLLAYFFYRDGVQTVIA- 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 223 YLPNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYtfgcLLVAF 302
Cdd:COG2270 260 FAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAF----WILGL 335
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1020085945 303 CAGIGNGTIF--------KLVPmyfSEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMAL 362
Cdd:COG2270 336 LIGLVMGGIQalsrsllaRLIP---PGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGSQRLGILSL 400
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
206-372 |
3.54e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.20 E-value: 3.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 206 LCIFYFLTFGSFVAFTVYLPNFlVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILS 285
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLY-AHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 286 FMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYF-SEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSE 364
Cdd:cd17489 80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIIpPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVL 159
|
....*...
gi 1020085945 365 VALACLII 372
Cdd:cd17489 160 ALLALLLV 167
|
|
| MFS_CynX_like |
cd17410 |
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of ... |
26-373 |
5.71e-04 |
|
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli cyanate transport protein CynX and similar proteins. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The gene encoding CynX is part of the cyn operon that also includes cynS, encoding cynase, which catalyzes the reaction of cyanate with bicarbonate to give ammonia and carbon dioxide, and cynT, which encodes a carbonic anhydrase. The CynX-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340968 [Multi-domain] Cd Length: 372 Bit Score: 41.63 E-value: 5.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 26 SSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFVG 105
Cdd:cd17410 19 GPLLNEIRAATGLSFQVASLLTVLPVLCMGLVALLGPWLARRVGERRGVALSLLAIAAACLWRLWSGTGPTLIASALLGG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 106 IGGAVFSVGVTSLPKYFPKESHGFVNGIYGVG-NAGTAITSFLAPVIA-TSVGWRTTVQCYLVlLAAFALMNFLLGDRKE 183
Cdd:cd17410 99 LGIAIIQALVPGLIKRRFPARVPLAMGLYSASlMAGGGLAASLSPRLAqHSAGWQLGLGIWAV-PALVALVLWWRQPPRE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 184 KKVNTPLMEQIKgVYKNEKLWFLCIFYFLTFGSFVAFTVYLPNFLVShFGLDKVDAGmrtaGFIVLATIMRPIGGW---- 259
Cdd:cd17410 178 VAPSDTAGPGVR-FFRNRRAWLLALYFGLINAGYTSMIAWLPAYYLE-LGWSAQDSG----SLLGFMTIFQVLGALvmpa 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 260 LGDKFNPFKILIFVFIGLTLSGII-LSFMPsmnvyTFGCLLVAFCAGIGNGTIFKLVPM----YFSE--QAGIVNGLVSA 332
Cdd:cd17410 252 LARRSADRRPLLMGALAAQLAGFLgLILMP-----QSLPLLWVALIGLGLGACFSLGLIlaldHLRKprAAGQLAAFVQG 326
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1020085945 333 LGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLIIT 373
Cdd:cd17410 327 IGFIITGISPWIAGWLRDSTGSFQAAWLLLAASVVAMLLLT 367
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
55-377 |
1.07e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 40.66 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 55 SVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFVGIGgAVFSVGVTSLPKYFPKESHGFVNGIY 134
Cdd:cd17472 46 AIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSG-AISSVVMALLADLTREENRTKAMALI 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 135 GVGNAGTAITSF-LAPVIATSVG-----WRTTVqcyLVLLAAFALMNFLLGDRKEKKVNTPLMEQIKGVYKNEKLWFLCI 208
Cdd:cd17472 125 GASIGIAFAISMvLGPLLAAHLGvsglfLITAI---LSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLLRLDF 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 209 FYFLTFGSFVAFTVYLPNFLVSHfGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFN-PFKILIFVFIGLTLSGIILSFM 287
Cdd:cd17472 202 SIFILHFVLMAFFYILPLLLTQL-GGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGkMKQVFVSSILLIAVGFLLLLFA 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 288 PSMNVYTFGCLLVAFcagIGNGTIFKLVPMYFSEQA-----GIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIgFMAL 362
Cdd:cd17472 281 ATSLWLLIIGLIIFF---IGFNLLEALLPSLVSKIApkeyrGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSV-FLTI 356
|
330
....*....|....*
gi 1020085945 363 SEVALACLIITVWMY 377
Cdd:cd17472 357 LILALLWLLVSFLLP 371
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
24-374 |
1.13e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 40.75 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 24 ILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLF 103
Cdd:cd17371 17 LLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 104 VGIG-GAVFSVGVTSLPKYFPKESHGFVNGIYGVGNA-----GTAITSFLAPVIATSVGWRttvqcYLVLLAAF-ALMNF 176
Cdd:cd17371 97 AGLGfGGEWAAGAALMAEYVPARHRGKALGYVQSGWAvgwllATLLAALLFPLLPPEIAWR-----VLFLLGALpALLVL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 177 LL---------------GDRKEKKVNTPLMEQIKGVYKNEKLWFLcIFYFLTFGSFvAFTVYLPNFLVSHFGLDKVDAGM 241
Cdd:cd17371 172 FIrrfvkeppqwqaaraARRHFADRPSLRELFSPPLLRTTLLASL-LATGALGGYY-GITTWLPSYLTGERGLSFEGSAG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 242 RTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSmnvyTFGCLLVA-FCAGIGNGTIFKLVPMYFS 320
Cdd:cd17371 250 YLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPL----SPTLILILgFPLGFFASGPFSGMGAYLT 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 321 E------QAGIVNGLVSALGGLGGFFPPLILTLLfqLTGHYAIGFMALSEVALACLIITV 374
Cdd:cd17371 326 ElfptavRATAQGFCYNVGRIIGALFPFLVGFLA--TSGSLGTAIAVFAAVYYIAGLVLA 383
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
22-156 |
1.70e-03 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 40.45 E-value: 1.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 22 WVILSSLMPYIKADIPLTAGQISMV-------TAVPVILGsvlripiGYWTNRFGARKLFFISFI---LLLFPVFYISVA 91
Cdd:PRK03893 292 WPIQALLPTYLKTDLGYDPHTVANVlffsgfgAAVGCCVG-------GFLGDWLGTRKAYVCSLLisqLLIIPVFAIGGA 364
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1020085945 92 NSmmdLIIGGLFvgIGGAVFSVGVTS-LPK----YFPKESH----GFvngIYGVGNAGTAITSFLAPVIATSVG 156
Cdd:PRK03893 365 NV---WVLGLLL--FFQQMLGQGISGlLPKliggYFDTEQRaaglGF---TYNVGALGGALAPILGALIAQRLD 430
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
13-179 |
2.08e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 39.89 E-value: 2.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 13 SNLVIGFMVWVILSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFIL--LLFPVFYISV 90
Cdd:COG2211 236 AYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLaaLGLLLLFFLG 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 91 ANSMMDLIIGGLFVGIGGAVFSVGVTSL--------PKYFPKESHGFVNGIYGVGN-AGTAITSFLAPVIATSVGWRTTV 161
Cdd:COG2211 316 PGNLWLLLVLAALAGIGLGAILVLPWAMladvvdydEWKTGRRREGLYFGIFTFAIkLGQALAGALAGLLLALFGYVAGA 395
|
170
....*....|....*...
gi 1020085945 162 QCYLVLLAAFALMNFLLG 179
Cdd:COG2211 396 AQSPSALTGIRLLFFLLP 413
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
230-289 |
4.00e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 39.14 E-value: 4.00e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1020085945 230 SHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKIL---IFVFIGLTLSGiilSFMPS 289
Cdd:cd17328 27 SDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILavgILIWSAATLLS---SFAPN 86
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
211-376 |
5.13e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 38.69 E-value: 5.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 211 FLTFGSFVAFTVYLpNFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSM 290
Cdd:cd17352 13 FFTDGILNSFGVLF-VELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 291 NVYtfgCLLVAFCAGIGNGTIFK----LVPMYFSEQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGhYAIGFMALSEVA 366
Cdd:cd17352 92 WQL---YLTYGVLGGLGLGLIYSpaivIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYG-WRGALLILGGLC 167
|
170
....*....|
gi 1020085945 367 LACLIITVWM 376
Cdd:cd17352 168 LNLCVCGLLL 177
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
25-113 |
5.86e-03 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 38.71 E-value: 5.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 25 LSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFV 104
Cdd:cd17358 25 LPSLMSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLA 104
|
....*....
gi 1020085945 105 GIGGAVFSV 113
Cdd:cd17358 105 GFGGGAASV 113
|
|
| MFS_NIMT_like |
cd17409 |
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of ... |
25-371 |
7.60e-03 |
|
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli 2-nitroimidazole transporter (NIMT), also called YeaN, and similar proteins. NIMT confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. The NIMT-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340967 [Multi-domain] Cd Length: 374 Bit Score: 38.01 E-value: 7.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 25 LSSLMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISvANSMMDLIIGGLFV 104
Cdd:cd17409 18 VAPLLDTIRESFGLSTAQAGLLTTLPLLAFALFSPLAAKLARRYGLERSLFAALLLIAAGIALRS-TGSVWALYLGTAII 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 105 GIGGAVFSVGVTSLPK-YFPkESHGFVNGIY----GVGNA-GTAITSFLAPVIATsvGWRTTVQCYLVL-LAAFALMNFL 177
Cdd:cd17409 97 GAGIAIGNVLLPSLLKrDFP-ARVATLTGAYaltmGVGAAlGSALVVPLAQVLAF--GWQLALGAFLVFpLVAALIWLPQ 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 178 LGDRKEKKVNTPLMEQIKGVYKNEKLWFLCIfyFLTFGSFVAFTV--YLPNFLVSHfGLDKVDAGmRTAGFIVLAT---- 251
Cdd:cd17409 174 LRRHTSPAADTAKPPHGGSVWRSPLAWQVTL--FLGLNSFIYYVLvgWLPSILTDA-GYSAAQAG-SLHGLLQLATavpg 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 252 -IMRPIGGWLGDKfnpfKILIFVFIGLTLSGII-LSFMPSMnvytfgCLLVAFCAGIGNGTIFKLVPMYFS------EQA 323
Cdd:cd17409 250 lLLIPVLARMKDQ----RLLAVLVSLLGAVGLIgLLLAPSL------AILWVILFGFGSGAGFILGLAFIGlrtssaHQA 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1020085945 324 GIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIGFMALSEVALACLI 371
Cdd:cd17409 320 AALSGMAQCVGYLLAATGPMLVGALHDLTGSWSVPLLLCAALALLMAI 367
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
231-323 |
7.76e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 37.94 E-value: 7.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 231 HFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGIILSFMPSMNVYTFGCLLVafcaGIGNGT 310
Cdd:cd17315 28 GFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLL----GLGVGL 103
|
90
....*....|...
gi 1020085945 311 IFKLVPMYFSEQA 323
Cdd:cd17315 104 ASVLVPLYISEIA 116
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
203-376 |
8.07e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 37.87 E-value: 8.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 203 LWFLCIFYFLTFGSFVAFTVYLPnFLVSHFGLDKVDAGMRTAGFIVLATIMRPIGGWLGDKFNPFKILIFVFIGLTLSGI 282
Cdd:COG0477 16 LLALALGTFLEGLDFTIVNVALP-SIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 283 ILSFMPSMNVYTFGCLLVAFCAGIGNGTIFKLVPMYFS-EQAGIVNGLVSALGGLGGFFPPLILTLLFQLTGHYAIgFMA 361
Cdd:COG0477 95 LCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPaRERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWI-FLI 173
|
170
....*....|....*
gi 1020085945 362 LSEVALACLIITVWM 376
Cdd:COG0477 174 NAPLGLLALVLRLRL 188
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
73-375 |
9.23e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 38.37 E-value: 9.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 73 LFFISFILLLFP-------------VFYISVANSMMDLII-----GGLFVGIGGAVFSVGVTS----------LPKYFPK 124
Cdd:PRK08633 55 LFLLPFLLLSSPagfladkfsknrvIRIVKLFEVGLTLLIvlayyLGWFWLAFAVTFLLGAQSaiyspakygiIPELVGK 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 125 ESHGFVNGIYGVGN-----AGTAITSFLAPVIATSVG-------WRTTVQCYLV----LLAAFALMNF-----LLGDRKE 183
Cdd:PRK08633 135 ENLSRANGLLEAFTivailAGTALFSFLFESVNGNTPseilgriAPAGLVLLAVavlgLIFAYRLPKVpaaapEVFDKKK 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 184 KKVNTPLMEQIKGVYKNEKLWfLCIF---YFLTFGSFVafTVYLPNFLVSHFGLDKVDAgmrTAGFIVLATIMRPIGGWL 260
Cdd:PRK08633 215 YLFPKLLWRNLKLLRSDRVLW-LAIIglsYFWFISQLA--QANFPAYAKEVLGLDNTFQ---VQYLLAASAIGIGIGSLL 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 261 GDKFNPFKI---LI-FVFIGLTLSGIILSFMPSMNVYTFGCLLVAFCAGigngtIFkLVPM-----YFSEQA--GIV--- 326
Cdd:PRK08633 289 AGRLSGRHIelgLVpLGALGLALSLFLLPTAPSLASVLVLFFLFGFSAG-----LF-IVPLnaliqFRAPEKelGKVlaa 362
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1020085945 327 NGLVSALGGLGGffppLILTLLFQLTGHYAIG-FMALSEVALACLIITVW 375
Cdd:PRK08633 363 NNFLQNVGMLLF----LALTTLFSGLGLSPAGlFYLIALVTLIGTLYTLL 408
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
28-358 |
9.38e-03 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 37.99 E-value: 9.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 28 LMPYIKADIPLTAGQISMVTAVPVILGSVLRIPIGYWTNRFGARKLFFISFILLLFPVFYISVANSMMDLIIGGLFVGIG 107
Cdd:PRK12307 40 IMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 108 GA-----VFSVGVTSLPKYFPKESHGFVNGIYGVGNagtAITSFLAPVIATSVGWRTTvqcYLVLLAAFALMNFLLGDRK 182
Cdd:PRK12307 120 MAgeyacASTYAVESWPKHLKSKASAFLVSGFGIGN---IIAAYFMPSFAEAYGWRAA---FFVGLLPVLLVIYIRARAP 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 183 EKK----------------VNTPLMEQIKGVYKNEKLWF-LCIFY--FLTFGSFVAFTVYLPNFLVSH-FGLDKVDAGMR 242
Cdd:PRK12307 194 ESKeweeaklsgkgkhsqsAWSVFSLSMKGLFNRAQFPLtLCVFIvlFSIFGANWPIFGLLPTYLAGEgFDTGVVSNLMT 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020085945 243 TAGF-IVLATImrpIGGWLGDKFNPFKILIfvfIGLTLSGII---LSFMPSMNVYTFG-CL--LVAFCAGIGnGTIFKLV 315
Cdd:PRK12307 274 AAAFgTVLGNI---VWGLCADRIGLKKTFS---IGLLMSFLFifpLFRIPQDNYLLLGaCLfgLMATNVGVG-GLVPKFL 346
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1020085945 316 PMYF-SEQAGIVNGLVSALGGLGGFFPPLILTLlfqLTGHYAIG 358
Cdd:PRK12307 347 YDYFpLEVRGLGTGLIYNLAATSGTFNSMAATW---LGITMGLG 387
|
|
|