|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15011 |
PRK15011 |
sugar efflux transporter SetB; |
1-393 |
0e+00 |
|
sugar efflux transporter SetB;
Pssm-ID: 184973 Cd Length: 393 Bit Score: 714.34 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 1 MHNTPAAASPKPFDLTSTAFLIVAFLTGIAGALQTPTLSLFLTNEVHARPAMVGFFFTGSAIIGIFVSQFLAGRSDRKGD 80
Cdd:PRK15011 1 MHNSPAVSSAKSFDLTSTAFLIVAFLTGIAGALQTPTLSIFLTDEVHARPAMVGFFFTGSAVIGILVSQFLAGRSDKRGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 81 RKSLIVFCCLLGVFACLLFAWNRNYFILLFVGVFLSSFGSTANPQMFALAREHADRTGREAVMFSSILRAQVSLAWVIGP 160
Cdd:PRK15011 81 RKSLIVFCCLLGVLACTLFAWNRNYFVLLFVGVFLSSFGSTANPQMFALAREHADKTGREAVMFSSFLRAQVSLAWVIGP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 161 PLAYALAMGFGFTVMYLSAAVAFVVCGAMVWFFLPSMRKEPKVATGTLEAPRRNRRDALLLFIICTLMWGTNSLYIINMP 240
Cdd:PRK15011 161 PLAYALAMGFSFTVMYLSAAVAFIVCGVMVWLFLPSMRKELPLATGTLEAPRRNRRDTLLLFVICTLMWGTNSLYIINMP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 241 LFIIDELHLPEKLAGIMMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVGMLTVHTPALLLALQLLNAIYIG 320
Cdd:PRK15011 241 LFIINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVAGVCFYAGMLMAHSPAILLGLQLLNAIYIG 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1022699636 321 ILAGIGMLYFQDLMPGQAGSATTLYTNTTRVGWIIAGSLAGVVAEIWNYHTVFWIALVMCVLTLSCLTRIKDV 393
Cdd:PRK15011 321 ILGGIGMLYFQDLMPGQAGSATTLYTNTSRVGWIIAGSLAGIVAEIWNYHAVFWFALVMIIATLFCLLRIKDV 393
|
|
| 2A0120 |
TIGR00899 |
sugar efflux transporter; This family of proteins is an efflux system for lactose, glucose, ... |
19-392 |
0e+00 |
|
sugar efflux transporter; This family of proteins is an efflux system for lactose, glucose, aromatic glucosides and galactosides, cellobiose, maltose, a-methyl glucoside and other sugar compounds. They are found in both gram-negative and gram-postitive bacteria. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 129977 Cd Length: 375 Bit Score: 516.63 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 19 AFLIVAFLTGIAGALQTPTLSLFLTNEVHARPAMVGFFFTGSAIIGIFVSQFLAGRSDRKGDRKSLIVFCCLLGVFACLL 98
Cdd:TIGR00899 1 AFLLVAFLTGIAGALQFPTLSLFLSEEVRARPAMIGLFYTGSAIVGIAVSQLLATRSDYQGDRKGLILFCCLLAALACLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 99 FAWNRNYFILLFVGVFLSSFGSTANPQMFALAREHADRTGREAVMFSSILRAQVSLAWVIGPPLAYALAMGFGFTVMYLS 178
Cdd:TIGR00899 81 FAWNRNYFLLLVLGVLLSSFASTANPQLFALAREHADRTGREAVMFSSVMRAQISLAWVIGPPLAFWLALGFGFTVMFLT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 179 AAVAFVVCGAMVWFFLPSMRKEPKVATGTLEAP-RRNRRDALLLFIICTLMWGTNSLYIINMPLFIIDELHLPEKLAGIM 257
Cdd:TIGR00899 161 AALAFVLCGVLVWLFLPSYPRGAPGALTRLEVRgLLASRDTRLLFVACTLMWGCNILYIINMPLLIIHELGLPDKLAGLM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 258 MGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVGMLTVHTPALLLALQLLNAIYIGILAGIGMLYFQDLMPGQ 337
Cdd:TIGR00899 241 MGTAAGLEIPFMLLAGYLIKRFGKRRLMLLAALAGVAFYTGLAADNSLWALLMLQLLNAIFIGILAGIGMLYFQDLMPGR 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1022699636 338 AGSATTLYTNTTRVGWIIAGSLAGVVAEIWNYHTVFWIALVMCVLTLSCLTRIKD 392
Cdd:TIGR00899 321 AGAATTLYTNTGRVGWIIAGSVGGILAERWSYHAVYWFAIVMLIVALFCLLLIKD 375
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
20-387 |
1.91e-145 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 417.33 E-value: 1.91e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 20 FLIVAFLTGIAGALQTPTLSLFLTNEVHARPAMVGFFFTGSAIIGIFVSQFLAGRSDRKGDRKSLIVFCCLLGVFACLLF 99
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLALLAGALGYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 100 AWNRNYFILLFVGVFLSSFGSTANPQMFALAREHADR-TGREAVMFSSILRAQVSLAWVIGPPLAYALAMGFGFTVMYLS 178
Cdd:cd17471 81 AFLRNYWVLLLVGVVLLSLGAAAFPQLFALAREYADRsSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 179 AAVAFVVCGAMVWFFLPSMRKEP-KVATGTLEAPRRNRRDALLLFIICTLMWGTNSLYIINMPLFIIDELHLPEKLAGIM 257
Cdd:cd17471 161 AALLYLVVALLVLFLLPSVKPPAqKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 258 MGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVGMLTVHTPALLLALQLLNAIYIGILAGIGMLYFQDLMPGQ 337
Cdd:cd17471 241 FGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMPGQ 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1022699636 338 AGSATTLYTNTTRVGWIIAGSLAGVVAEIWNYHTVFWIALVMCVLTLSCL 387
Cdd:cd17471 321 PGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLL 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
19-356 |
1.50e-26 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 108.52 E-value: 1.50e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 19 AFLIVAFLTGIAGALQTPTLSLfLTNEVHARPAMVGFFFTGSAIiGIFVSQFLAGR-SDRKGdRKSLIVFCCLLGVFACL 97
Cdd:COG2814 14 ALALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLL-GAALGAPLAGRlADRFG-RRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 98 LFAWNRNYFILLFVGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAMGFGFTVMYL 177
Cdd:COG2814 91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRAL--GLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 178 SAAVAFVVCGAMVWFFLPSMRKEPKVATGTLEAPRRNRRDALLLFIICTLMWGTNSLYIINMPLFIIDELHLPEKLAGIM 257
Cdd:COG2814 169 VNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 258 MGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVGMLTVHTPALLLALQLLNAIYIGILAGIGMLYFQDLMPGQ 337
Cdd:COG2814 249 LALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPE 328
|
330 340
....*....|....*....|
gi 1022699636 338 A-GSATTLYTNTTRVGWIIA 356
Cdd:COG2814 329 ArGRASGLYNSAFFLGGPLA 348
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
20-384 |
6.48e-23 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 99.04 E-value: 6.48e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 20 FLIVAFLTGIAGALQTPTLSLFLTnEVHARPAMVGFFFTGSAIIGIFVSQFLAGRSDRKGdRKSLIVFCCLLGVFACLLF 99
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQ-SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFG-RRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 100 AWNRNYFILLFVGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAM--GFGFTVMYL 177
Cdd:cd06174 79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRAL--GLLQAFGSVGGILGPLLGGILASslGFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 178 SAAVAFVVCGAMVWFFLPSMRKEPKVATGTLEAPR--------RNRRDALLLFIICTLMWGTNSLYIINMPLFIIDELHL 249
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESARAKNEEASSKSvlkllkrvLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 250 PEKLAGIMMGTAAGLEIPTMLIAGYYAKR-FGKRFLMRIAAAAGLLFYVGMLTVHTPALLLALQLLNAIYIGILAGIGML 328
Cdd:cd06174 237 SVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFA 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1022699636 329 YFQDLMP-GQAGSATTLYTNTTRVGWIIAGSLAGVV-AEIWNYHTVFWIALVMCVLTL 384
Cdd:cd06174 317 LIAELFPpEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAA 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
20-356 |
9.15e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 97.87 E-value: 9.15e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 20 FLIVAFLTGIAGALQTPTLSLFLTNEVHARPAMVGFFFTGSAIIGIFVSQFLAGRSDRKGDRKsLIVFCCLLGVFACLLF 99
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRR-VLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 100 AWNRNYFILLFVGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAMGFGFTVMYLSA 179
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRAL--GLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 180 AVAFVVCGAMVWFFLPSMRKEPKVATGTLEAPRRN------RRDALLLFIICTLMWGTNSLYIINMPLFiIDELHLPEKL 253
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVawkallRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 254 AGIMMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVGMLTVHTPALLLALQLLNAIY---IGILAGIGMLYF 330
Cdd:pfam07690 237 AGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLgfgFGLVFPALNALV 316
|
330 340
....*....|....*....|....*..
gi 1022699636 331 QDLMP-GQAGSATTLYTNTTRVGWIIA 356
Cdd:pfam07690 317 SDLAPkEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
20-384 |
1.21e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 98.03 E-value: 1.21e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 20 FLIVAFLTGIAGALQTPTLSLFLTnEVHARPAMVGFFFTGSAIIGIFVSQFLAGRSDRKGdRKSLIVFCCLLGVFACLLF 99
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAE-SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFG-RKRLLLLGLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 100 AWNRNYFILLFVGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAMGFGFTVMYLSA 179
Cdd:cd17325 79 AFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAM--GIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 180 AVAFVVCGAMVWFFLPSMRKEPKVATGTLEAPR------RNRRDALLLFIICTLMWGTNSLYIINMPLFIIDELHLPEKL 253
Cdd:cd17325 157 AALALLALVLALLLLPEPRPPPNKRAVSAARLRsglrllLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQ 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 254 AGIMMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVGMLTVHTPALLLALQLLNAIYIGILAGIGMLYFQDL 333
Cdd:cd17325 237 IGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADI 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1022699636 334 MP-GQAGSATTLYTNTTRVGWIIAGSLAGVVAEIWNYHTVFWIALVMCVLTL 384
Cdd:cd17325 317 VPpEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAA 368
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
19-387 |
4.25e-20 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 91.50 E-value: 4.25e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 19 AFLIVAFLTGIAGALQTPTLSLFLTNEVHARPAMVGFFFTGSAIIGIFVSQFLAGRSD----RKGDRKSLIVFCCLLGVF 94
Cdd:COG2211 14 AYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWILIGAIPLAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 95 ACLLFAWNRN-----YFILLFVGVFLSSFGSTA-----NPQMFALAREHADRTgreavMFSSILRAQVSLAWVIGPPLAY 164
Cdd:COG2211 94 SFVLLFTAPDlsptgKLIYALVTYLLLGLAYTLvnipySALGAELTPDYEERT-----RLSSWRFAFAGLGGLLASVLPP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 165 ALAMGF------GFTVMYLSAAVAFVVCGAMVWFFLPSMRKEPKVATGTLE---APRRNRrDALLLFIICTLMWGTNSLY 235
Cdd:COG2211 169 PLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKEslkALLKNR-PFLLLLLAYLLFFLALALV 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 236 IINMPLFIIDELHLPEKLAGIMMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVGMLTVHTPALLLALQLLN 315
Cdd:COG2211 248 AALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAA 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 316 AIYIGILAGIGMLY--------FQDLMPGQ--AGSATTLYTNTTRVGWIIAGSLAGVVAEIWNY--------HTVFWIAL 377
Cdd:COG2211 328 LAGIGLGAILVLPWamladvvdYDEWKTGRrrEGLYFGIFTFAIKLGQALAGALAGLLLALFGYvagaaqspSALTGIRL 407
|
410
....*....|
gi 1022699636 378 VMCVLTLSCL 387
Cdd:COG2211 408 LFFLLPAVLL 417
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
15-388 |
2.74e-19 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 88.38 E-value: 2.74e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 15 LTSTAFLIVAFLTGIAGALQTptlslfLTNEVHARPAMVGFFFTGSAIIGIFVSQFLAGRSDRKGdRKSLIVFCCLLGVF 94
Cdd:cd17324 4 LALAAFAIGTTEYVIQGLLPD------IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIE-RRRLLLVLLLLFIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 95 ACLLFAWNRNYFILLFVGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAMGFGFTV 174
Cdd:cd17324 77 GNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAI--GLVFSGLTLGLVLGRPLGGLLGQLLGWRA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 175 MYLSAAVAFVVCGAMVWFFLPSMRKEPKVATGTLEAPRRNRRDALLL--FIICTLMWGTNSLYIINMPLFIIDELHLPEK 252
Cdd:cd17324 155 AFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLRlaYLITFLLFGGFFALYTYLAPFLTDVPGFSSS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 253 LAGIMMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVGMLTVHTPALLLALQLLNAIYIGILAGIGMLYFQD 332
Cdd:cd17324 235 AIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLR 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1022699636 333 LMPGQAGSATTLYTNTTRVGWIIAGSLAGVVAEIWNYHTVFWIALVMCVLTLSCLT 388
Cdd:cd17324 315 LAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
21-384 |
4.18e-17 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 81.89 E-value: 4.18e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 21 LIVAFLTGIAGALQTPTLSLFLTNEVHARPAMVGFFFTGSAIIGIFVSqFLAGR-SDRKGDRKSLIVFCCLLGV-FACLL 98
Cdd:cd17329 5 LIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVAS-LIGGRlADRFGRKPVMLAGLLLRALgFALLG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 99 FAWNrnyFILLFVGVFLSSFGSTA-NPQMFALAREHADRTGREAVmfSSILRAQVSLAWVIGPPLAYALAMgFGFTVMYL 177
Cdd:cd17329 84 FAHS---PWLFAIALVLTGFGGGLfEPASEAMIADVTTPENRTRA--FSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 178 SAAVAFVVCGAMVWFFLP--SMRKEPKVATGTLEAPRRNRRDA-----LLLFIICTLMWGTNSLYIinmPLFIIDELHLP 250
Cdd:cd17329 158 AAAVLFLLAALVLLFLLPetRPKRRAAEKTEILRGYKIVLRDRafllfLLASFLISLIYFQLESTL---PVYVVEILGLG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 251 EKLAGIMMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVGMLTVHTPALLLALQLLNAIYIGILAGIGMLYF 330
Cdd:cd17329 235 ESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLV 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1022699636 331 QDLMP-GQAGSATTLYTNTTRVGWIIAGSLAGVVAEIWNYHTVFWIALVMCVLTL 384
Cdd:cd17329 315 AALAPpDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAA 369
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
11-384 |
6.61e-17 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 81.44 E-value: 6.61e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 11 KPFDLTSTAFLIVAFLTGIAGalqtpTLSLFLTNEVHARPAMVGFFFTGSAIiGIFVSQFLAGRSDRKGDRKSLIVFCCL 90
Cdd:COG0738 8 RALIAIYLLFFLWGFATALWG-----PLIPALKDAFGLSDAQAGLLLFAFFL-GYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 91 LGVFACLLFAWNRNYFILL----FVGVFLSSFGSTANPQMFALAREHADRtgreavmFSSILRAQVSLAWVIGPPL-AYA 165
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLlalfLLGLGLGLLDVAANPYVAALGPETAAS-------RLNLLHAFFSLGALLGPLLgGLL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 166 LAMGFGFTVMYLSAAVAFVVCGAMVWFF---LPSMRKEPKVATGTLEAPRRNRRDALLLFIICTLMWGTNSLYIIN--MP 240
Cdd:COG0738 155 ILLGLSLSWHLPYLILAVLLLLLALLFLrskLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGdwLP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 241 LFIIDELHLPEKLAGIMMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVGMLTVHTPALLLALQLLNAIYIG 320
Cdd:COG0738 235 LYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLS 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1022699636 321 ILAGIGMLYFQDLMPGQAGSATTLYTNTTRVGWIIAGSLAGVVAEIWNYHTVFWIALVMCVLTL 384
Cdd:COG0738 315 LMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLIL 378
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
19-383 |
1.36e-14 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 74.57 E-value: 1.36e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 19 AFLIVAFLTGIAGALQTPTLSLFLTnEVHARPAMVGFFFTGSAIIGIFVSQFLAGRSDRKGDRKSLIVFCCLLGVFA--- 95
Cdd:cd06173 3 LLWLAQLLSALGDWIFTVALPWLVL-QLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAavl 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 96 CLLFAWNRNYFILLFVGVFLSSFGSTA-NPQMFALAREHADRtgREAVMFSSILRAQVSLAWVIGPPLAYALAMGFGFTV 174
Cdd:cd06173 82 ALLALLGSLSLWLLLVLAFLLGIASAFfGPARQALLPELVPK--EQLVRANALNSLATQLARIIGPALGGLLVALLGPGG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 175 MYLSAAVAFVVCGAMVWFFLPSMRKEPKVATGTLEAP-------RRNRRDALLLFIICTLMWGTNSLYIINMPLFIIDEL 247
Cdd:cd06173 160 AFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDlreglryLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 248 HLPEKLAGIMMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVGMLTVHTPALLLALQLLNAIYIGILAGIGM 327
Cdd:cd06173 240 GGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLN 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1022699636 328 LYFQDLMPGQ-AGSATTLYTNTTRVGWIIAGSLAGVVAEIWNYHTVFWIALVMCVLT 383
Cdd:cd06173 320 TLLQLRVPDElRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLA 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
19-194 |
2.47e-14 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 73.76 E-value: 2.47e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 19 AFLIVAFLTGIAGALQTPTLSLFLTNEVHARPAMVGFFFTGSAIIGIFVSQFLAGRSDRKGdRKSLIVFCCLLGVFACLL 98
Cdd:cd17325 203 ALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIG-RKPLILIGLLLSAVALLL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 99 FAWNRNYFILLFVGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAMGFGFTVMYLS 178
Cdd:cd17325 282 LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAM--GLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLA 359
|
170
....*....|....*.
gi 1022699636 179 AAVAFVVCGAMVWFFL 194
Cdd:cd17325 360 AAALLLLAAVLFLLLR 375
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
21-391 |
5.26e-14 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 72.60 E-value: 5.26e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 21 LIVAFLTGIAGALQTPTLSLF---LTNEVHARPAMVGFFFTGSAIiGIFVSQFLAGR-SDRKGDRKsLIVFCCLLGVFAC 96
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAappLQADLGLSAAQLGLLASAFFL-GYALGQIPAGLlADRFGRRR-VLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 97 LLFAWNRNYFILLFVGVFLSSFGSTANPQMFALAREHADRtgREAVMFSSILRAQVSLAWVIGPPLAYALAMGFGF-TVM 175
Cdd:COG2271 90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPP--KERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWrAAF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 176 YLSAAVAFVVCGAMVWfflpsmrkepkvatgtleaprrnrrdalLLFIICTLMWGTNSLYIINMPLFIIDELHLPEKLAG 255
Cdd:COG2271 168 LILGLPGLLLALLRFW----------------------------LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 256 IMMGTAAGLEIPTMLIAGYYAKRFGKR--FLMRIAAAAGLLFYVGMLTVHTPALLLALQLLNAIYIGILAGIGMLYFQDL 333
Cdd:COG2271 220 LLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAEL 299
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1022699636 334 MPGQ-AGSATTLYTNTTRVGWIIAGSLAGVVAEIWNYHTVFWIALVMCVLTLSCLTRIK 391
Cdd:COG2271 300 FPKKaRGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
21-384 |
1.01e-13 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 71.46 E-value: 1.01e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 21 LIVAFLTGIAGALQTPTLSLFLT--NEVHARPAMVGFFFTGSAIIGIFVSQFLAGRSDRKGDRKSLIVfcCLLGVFACLL 98
Cdd:cd17330 2 FLVVFLDALGFGIVFPVLPFYVRefNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLL--SLAGSAVSYV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 99 FAWNRNYFILLFVGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAMGFGFTVMYLS 178
Cdd:cd17330 80 LLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAF--GIISAAFGLGFILGPALGGFLSTPYGYALPFLV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 179 AAVAFVVCGAMVWFFLPSMRkepkvatgtleaprrnrrdalLLFIICTLMWGTNSLYIINMPLFIIDELHLPEKLAGIMM 258
Cdd:cd17330 158 AAALALLNLVLVLFFLPPLR---------------------RLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 259 GTAAGLEIPT-MLIAGYYAKRFGKRFLMRIAAAAGLLFYVGMLTVHTPALLLALQLLNAIYIGIL-AGIGMLYFQDLMPG 336
Cdd:cd17330 217 ALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVfPALSALLSKSVPSK 296
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1022699636 337 QAGSATTLYTNTTRVGWIIAGSLAGVVAEIWNYHTVFWIALVMCVLTL 384
Cdd:cd17330 297 EQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIAL 344
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
51-387 |
1.12e-13 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 71.43 E-value: 1.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 51 AMVGFFFTGSAIIGIFVSQFLAGRSDRKGdRKSLIVFCCLLGVFACLLFAWNRNYFILLFVgVFLSSFGSTA-NPQMFAL 129
Cdd:cd17478 31 AQAGLLVSVFSITSSLLQPLFGYLADRKP-RRYLLPLGPLLTGLGLSLLGFAPNYWLLLLL-VALAGIGSAAfHPEGARL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 130 AREHAdrtGREAVMFSSILRAQVSLAWVIGPPLAYALAMGFGFTVMYLSAAVAFVVCGAMVWFFLPSMRKEPKVATGTLE 209
Cdd:cd17478 109 ASQAA---GGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 210 APRRNRRDALLLFIICTLM----WGTNSLyIINMPLFIIDELhLPEKLAGIMMGTAAGLEIPTMLIAGYYAKRFGKRFLM 285
Cdd:cd17478 186 ARSTLKGVWRALLLLLIIVflrsWVLSSL-TTFLPFYLVQRG-YSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVI 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 286 RIAAAAGLLFYVGMLTVHTPALLLALQLLNAIyIGILAGIGMLYFQDLMPGQAGSATTLYTNttrVGWIIAG---SLAGV 362
Cdd:cd17478 264 IASLLLAAPFLLLFLLTPGIWSYILLVLAGFL-LFASFPVTVVLAQELLPGNVGLASGLMMG---LSFGLGGigaPVLGA 339
|
330 340
....*....|....*....|....*
gi 1022699636 363 VAEIWNYHTVFWIALVMCVLTLSCL 387
Cdd:cd17478 340 LADAFGLESVLLILALLPLLGALLA 364
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
63-387 |
9.87e-11 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 62.59 E-value: 9.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 63 IGIFVSQFLAGR-SDRKGDRKSLIVFCCLLGVfACLLFAWNRNYFILLFvGVFLSSFGSTANPQM-FALAREHADrtGRE 140
Cdd:cd17320 45 LGFALGQLLYGPlSDRFGRRPVLLAGLLLFIL-ASLLCALASSIEQLLI-ARFLQGLGAAAGSVVaRAIVRDLYS--GAE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 141 AVMFSSILRAQVSLAWVIGPPLAYALAMGFGFTVMYLSAAVAFVVCGAMVWFFLPSMRKEPKVATGTLEAPRRNR----- 215
Cdd:cd17320 121 LAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKrvlkn 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 216 RDALLLFIICTLMWGTNSLYIINMPLFIIDELHLPEKLAGIMMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIA-----AA 290
Cdd:cd17320 201 RRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGlllllAA 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 291 AGLLFYVGMLTVHTPALLLALQLLNAIYIGILAGIGMLYFQDLMPGQAGSATTLYTNTTRVGWIIAGSLAGVVAEIWNyH 370
Cdd:cd17320 281 ALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTA-L 359
|
330
....*....|....*..
gi 1022699636 371 TVFWIALVMCVLTLSCL 387
Cdd:cd17320 360 PMGLLILVLGLLALLLL 376
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
19-391 |
1.48e-10 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 62.21 E-value: 1.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 19 AFLIVAFLTGIAGALQTPTLSLFLTNEVHARPAMVGFFFTGSAIIGIFVSQFLAGRSDRKGDRKsLIVFCCLLGVFACLL 98
Cdd:COG2223 8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRR-VLLIGLLLLGIGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 99 FAWNRNYFILLFVGVFLSSFGSTANPQMFALAREH--ADRTGreavMFSSILRAQVSLAWVIGPPLAYALAMGFGFTVMY 176
Cdd:COG2223 87 LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWfpPDRRG----LALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 177 LSAAVAFVVCGAMVWFFlpsMRKEPKVATGTLEAPRRNRRDAL------LLFIICTLMWGTNSLYIINMPLFIIDELHLP 250
Cdd:COG2223 163 LILGILLLVVAVLAWLF---LRDPPAGAAAAAKASLRDQLEALrdprfwLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 251 EKLAGIMMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVGMLTVHTPALLLALQLLNaiyIGILAGIGMLYF 330
Cdd:COG2223 240 AATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLL---LGLALGGGNGAV 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1022699636 331 QDLMP-----GQAGSATTLYTNTTRVGWIIAGSLAGVVAEIW-NYHTVFWIALVMCVLTLSCLTRIK 391
Cdd:COG2223 317 FALVPdifptKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLLY 383
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
50-384 |
3.98e-10 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 60.68 E-value: 3.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 50 PAMVGFFFTGSAIIGIFVSQFLAGRSDRKGDRKSLIVFCCLLGVFACLLFAWNRNYFILLFVGVFLSSFG-STANPQM-- 126
Cdd:cd17335 31 PTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFFVAQIFWLLLLLVILGAFFsAPVVPLVds 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 127 --FALAREHADRTGREAvMFSSIlraqvslAWVIGpplayALAMGFGFT----------VMYLSAAVAFVVCGAMVWFFL 194
Cdd:cd17335 111 itLQYLGEERERYGKQR-LWGSI-------GFGIA-----ALLVGILIDrsstyknytiAFYVFAVLMLLALLLALKFPF 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 195 PSMRKEPKVATGTLEAPRRNRRdALLLFIICTLMWGTNSLYIINMPLFIiDELHLPEKLAGIMMGTAAGLEIPTMLIAGY 274
Cdd:cd17335 178 RPKHPEPNENTGGLLALLRNPR-VLAFLLVAFLMGFGHGLIYSFLFWHL-QDLGGSKTLIGLLWTVGVVSEIPFFFFSSR 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 275 YAKRFGKRFLMRIAAAAGLLFYVGMLTVHTPALLLALQLLNAIYIGILAGIGMLYFQDLMP-GQAGSATTLYTNTTR-VG 352
Cdd:cd17335 256 LIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPpGLRATAQGLLQGLYFgLG 335
|
330 340 350
....*....|....*....|....*....|..
gi 1022699636 353 WIIAGSLAGVVAEIWNYHTVFWIALVMCVLTL 384
Cdd:cd17335 336 GGLGSLIGGYLYEAFGARTTFRFFAIAALAGL 367
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
21-384 |
5.06e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 60.30 E-value: 5.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 21 LIVAFLTGIAGALQTPTLSLFLtNEVHARPAMVGFFfTGSAIIGIFVSQFLAGRSDRKGDRKSLIVFCCLLGVFACLLFA 100
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYA-HDLGGSEAVAGLV-VGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 101 WNRNYFILLFVGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAMGFGFTVMYLSAA 180
Cdd:cd17489 80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGI--GYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 181 VAFVVCGAMVWFF-LPSMRKEPKVATGTLEAPRRNRRDALLLFIICTLMWGTNSLYIINMPLFIIDELHlpeKLAGIMMG 259
Cdd:cd17489 158 VLALLALLLVFLVkDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGI---SNAGLFFT 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 260 TAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVGMLTVHTPALLLALQLLNAIYIGILA-GIGMLYFQDLMPGQA 338
Cdd:cd17489 235 VYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFpALQALAVDLVPPHRR 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1022699636 339 GSATTLYTNTTRVGWIIAGSLAGVVAEIWNYHTVFWIALVMCVLTL 384
Cdd:cd17489 315 GAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLAL 360
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
20-185 |
2.10e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 58.36 E-value: 2.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 20 FLIVAFLTGIAGALQTPTLSLFLTNEVHARPAMVGFFFTGSAIIGIFVSQFLAGRSDRKGDRKSLIVFCCLLGVFACLLF 99
Cdd:cd17330 179 LLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 100 AWNRNYFILLFVGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAMGFGFTVMYLSA 179
Cdd:cd17330 259 PFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQ--GIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLA 336
|
....*.
gi 1022699636 180 AVAFVV 185
Cdd:cd17330 337 AGLLLI 342
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
47-390 |
3.18e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 57.97 E-value: 3.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 47 HARPAMVGFFFTGSAIIGIFVSQFLAGRSDRKGdRKSLIVFCCLLGVFACLLFAWNRNYFILLFV----GVFLSSFGSTA 122
Cdd:cd17474 30 GASPAQVGLLITAFTLPAAVLMPVAGVLADRFG-RKKVLLPGLLLFGIGGLLCGLSDSFALLLAGralqGIGAAGLGPLA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 123 NPQMFALAREHAdrtgREAVMfsSILRAQVSLAWVIGPPLAYALAMGFGFTVMYLSAAVAFVVCGAMVWFFLPSMRKEPK 202
Cdd:cd17474 109 LTLIGDLFEGGE----RAKAM--GLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKS 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 203 VATGTLEAPRRNRRDALLL---FIICTLMWGTnSLYIINMPLFIIDELHLPEKLAGIMMGTAAGLeipTMLIAGYYAKRF 279
Cdd:cd17474 183 SSATKLRDLKKALRGRGLLtflVSAFLYFFLY-FAFLTYLPFLLELLYGISPIIIGLLFAGWSVL---LALGSLFVGRLL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 280 GKRFLMRIAAAAGLLFYVGMLTVHTPALLLALQLLNAIYIGILAGIGMLYFQDLMPGQA-----GSATTLYTNTTRVGWI 354
Cdd:cd17474 259 KKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELApeeerGTASSLYNFVRFLGQA 338
|
330 340 350
....*....|....*....|....*....|....*.
gi 1022699636 355 IAGSLAGVVAEIWNYHTVFWIALVMCVLTLSCLTRI 390
Cdd:cd17474 339 VGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
36-389 |
1.01e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 56.48 E-value: 1.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 36 PTLSLFLTNEVHARPAMVGFFfTGSAIIGIFVSQFLAGR-SDRKGDRKSLIVFCCLLGVFACLLfAWNRNYFILLFVGVF 114
Cdd:cd17475 16 PALAPFLQEDLHLSLAQVGLL-LSALNLGVAVSMLPAGWlLDRFGERRVLAVGLLLMGAAALLM-ALVGSYPVLLVLLFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 115 LSSFGSTANPqmfalarehadrTGREAVM--FS--------SILRAQVSLAWVIGPPLAYALAMGFGFTVMYLSAAVAFV 184
Cdd:cd17475 94 VGAGYGSVQP------------GGGRAIMrwFPprerglamGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 185 VCGAMVWFFL---PSMRKEPKVATGTLEAPRRNRRDA--LLLFIICTLMWGTNSLYIINMPLFIIDELHLPEKLAGIMMG 259
Cdd:cd17475 162 LAAVLFWLFYrepPAASAATESASTLLRSLKEVLRNRdvWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 260 TAAGLEIPTMLIAGYYAKRF--GKRF-LMRIAAAAGLLFYVGMLtVHTPALLLALQLLNAIYIGILA----GIGMLYFQD 332
Cdd:cd17475 242 VAQLGGALGRIGLGRVSDRVfgGRRRpVLVITAAIAAAALLVLS-LLSPGTPLWLLVLLLILLGLFAigwnGLYLTLVAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1022699636 333 LMP-GQAGSATTLYTNTTRVGWIIAGSLAGVVAEIWNYHTVFWIALVMCVLTLSCLTR 389
Cdd:cd17475 321 SAGpEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
22-379 |
1.12e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 56.40 E-value: 1.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 22 IVAFLTGIAGALQTPTLSLFLTnEVHARPAMVGFFfTGSAIIGIFVSQFLAGR-SDRKGDRKSLIVFCCLLGVFACLLFA 100
Cdd:cd17370 6 LVSLFADISYEMARSILPLFLV-VLGASAAAVGLI-EGLAEALGSLLRLFSGYlSDRTGKRKPLVILGYGLSALAKPLLA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 101 WNRNYFILLFVgVFLSSFGSTA-NPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAMGFGF---TVMY 176
Cdd:cd17370 84 LAGSWQLVLLL-RILERLGKGIrTPPRDALLADATPPSGRGKAF--GLHRALDTLGAVLGPLLAALLLYLLGGnyrTIFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 177 LSAAVAFVVCGAMVWFFLPSMRKEPKVATGTLEAPRRNRRDALLLFIICTLMWGTNSLYIinMPLFIIDELHLPEKLAGI 256
Cdd:cd17370 161 LAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFA--FLILRAQELGLSAALIPL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 257 MMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVGMLTVHTPALLLALQLLNAIYIGILAGIGMLYFQDLMPG 336
Cdd:cd17370 239 LYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPA 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1022699636 337 QA-GSATTLYTNTTRVGWIIAGSLAGVVAEIWNYHTVFWIALVM 379
Cdd:cd17370 319 ELrGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVL 362
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
210-389 |
1.30e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 56.14 E-value: 1.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 210 APRRNRRDALLLFIICTLMWGTNSLYIINMPLfIIDELHLPEKLAGIMMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAA 289
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 290 AAGLLFYVGMLTVHTPALLLALQLLNAIYIGILAGIGMLYFQDLMPG-QAGSATTLYTNTTRVGWIIAGSLAGVVAEIWN 368
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPeRRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180
....*....|....*....|.
gi 1022699636 369 YHTVFWIALVMCVLTLSCLTR 389
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLR 183
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
18-193 |
2.78e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 55.27 E-value: 2.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 18 TAFLIVAFLTGIAGALQTpTLSLFLTNEVHARPAMVGFFFTGSAIIGIFVSQFLAGRSDRKGDRKSLIVFCCLLGVFACL 97
Cdd:cd17474 202 TFLVSAFLYFFLYFAFLT-YLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 98 LFAWNRNYFILLFVGVFLSSFGSTANPQMFALAREHADRTGREAVM--FSSILRaqvsLAWVIGPPLAYALAMGFGFTVM 175
Cdd:cd17474 281 LLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASslYNFVRF----LGQAVGPLLFGLLLEIFGLSAP 356
|
170
....*....|....*...
gi 1022699636 176 YLSAAVAFVVCGAMVWFF 193
Cdd:cd17474 357 FLVGAAIALAAAVLLALL 374
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
22-382 |
2.74e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 51.94 E-value: 2.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 22 IVAFLTGIAGALQTPTLsLFLTNEVHARPAMVGFFFTGSaIIGIFVSQFLAGR-SDRKGDRKSLIVFCCLLGVFACLLFA 100
Cdd:cd17333 3 ISFFSNGLTDALLGILG-PSLEEAFNLNVADVSVIFSSQ-NAGYLIGSLLAGFlMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 101 wnRNYFILLFVGVFLSSFG-----STANPQMFALAREhadrtGREAVMfsSILRAQVSLAWVIGPPLA-YALAMGFGFTV 174
Cdd:cd17333 81 --TPSIYLFVVLMFLAGLGagildTGANTFVGALFEE-----SSATRL--NVLHGFFGLGALIGPLIAtSLLTSELSWSW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 175 MYLsAAVAFVVCGAMVWFFLPSM----RKEPKVATGTLEAP--RRNRRDALLLFIICTLMW-GTNSLYIINMPLFIIDEL 247
Cdd:cd17333 152 AYL-IIGLIYLLLAILILLTLFPelpsARNPQQSVGAFSASasRLLRNPSIILGALALFLYvGAETAFSSWVPSYLVEKK 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 248 HLPEKLAGIMMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVGMLTVHTPALLLALQLLNAIYIGILAGIGM 327
Cdd:cd17333 231 HVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTIL 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1022699636 328 LYFQDLMPGQAGSATTLYTNTTRVGWIIAGSLAGVVAEIWNYHTVFWIALVMCVL 382
Cdd:cd17333 311 SLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAI 365
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
21-382 |
5.54e-07 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 51.12 E-value: 5.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 21 LIVAFLTGIAGALQTPTLSLFLTNEVHAR---PAMVGFFFTGSAIIGIFVSQFLAGRSDRKGDRKSLIVFCCLLGVfACL 97
Cdd:cd17355 5 LAVTFLILILSWGIRYYFGVFIIPIIAEFgwsRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA-GLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 98 LFAWNRNYFiLLFVGVFLSSFGSTANPQMFALAREHADRTGREAVMFSSILRAQVSLAWVIGPPLAYALAMGFGFTVMYL 177
Cdd:cd17355 84 LLALATSLW-QLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 178 SAAVAFVVCGAMVWFFLPSMRKEPKVATGTLEAPRRNR-------RDALLLFIICTLMWGTNSLYIINMPLFI-IDELHL 249
Cdd:cd17355 163 VLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGstlkealRSASFWLLALAFFLCGFAVVGLIVHLVPyLADRGI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 250 PEKLAGIMMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVGMLTVHTPALLLALQLLN--AIYIGILAGIGM 327
Cdd:cd17355 243 SPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALfgLGWGATVPLTAA 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1022699636 328 LYFQDLMPGQAGSATTLYTNTTRVGWIIAGSLAGVVAE-IWNYHTVFWIALVMCVL 382
Cdd:cd17355 323 LAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDrTGSYTAAWALAVALGLI 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
221-384 |
9.76e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.11 E-value: 9.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 221 LFIICTLMWGTNSLYIINMPLFIIDELHLPEKLAGIMMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVGML 300
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 301 TVHTPALLLALQLLNAIYIGILAGIGMLYFQDLMPGQA-GSATTLYTNTTRVGWIIAGSLAGVVAEIWNYHTVFWIALVM 379
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEErGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
....*
gi 1022699636 380 CVLTL 384
Cdd:pfam07690 161 SLLAA 165
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
21-193 |
1.67e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.54 E-value: 1.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 21 LIVAFLTGIAGALQTPTLSLFLTNEVHARPAMVGFFFTGSAIiGIFVSQFLAGRSDRKGDRKSLIVFCCLLGVFACLLFA 100
Cdd:cd06173 214 LLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGV-GALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLG 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 101 WNRNYFILLFVGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAMGFGFTVMYLSAA 180
Cdd:cd06173 293 LSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVF--SVYNALNSGAMPLGALLAGLLADALGLSAVFLLAG 370
|
170
....*....|...
gi 1022699636 181 VAFVVCGAMVWFF 193
Cdd:cd06173 371 ALLLLAALLLLLL 383
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
227-393 |
3.18e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 48.74 E-value: 3.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 227 LMWGTNSLYIINMPLFIIDeLHLPEKLAGIMMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVGMLTVHTPA 306
Cdd:cd17489 7 FFFLSFYLLLPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 307 LLLALQLLNAIYIGILAGIGMLYFQDLMPGQ-AGSATTLYTNTTRVGWIIAGSLAGVVAEIWNYHTVFWIALVMCVLTLS 385
Cdd:cd17489 86 LLLVLRLIHGIGWGAFTTAAATLVADIIPPSrRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALL 165
|
....*...
gi 1022699636 386 CLTRIKDV 393
Cdd:cd17489 166 LVFLVKDP 173
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
5-384 |
3.36e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 48.72 E-value: 3.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 5 PAAASPKPFDLTSTAFLIVAFLTGIAGALQTPTLSL-----FLTNEVHARPAMVGFFFTGSAIIGIFVSqFLAGR-SDRK 78
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVgpllpEIRADLGLSATQAGLLTTLPLLAFGLFA-PLAPRlARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 79 GDRKSLIVfcCLLGVFACLLFAWNRNYFILLFVGVFLSSFGST-ANPQMFALAREH-ADRTGREAVMFSSILraqvSLAW 156
Cdd:COG2807 81 GLERTLLL--ALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAvGNVLLPGLIKRWfPDRVGLMTGLYTAAM----GLGA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 157 VIGPPLAYALAMGFGFTVMYLSAAVaFVVCGAMVWFFLPSMRKEPKVATGTLEAPRRNRRDALLLFIicTLMWGTNSL-- 234
Cdd:COG2807 155 ALAAGLTVPLAAALGWRGALAVWAL-LALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLL--TLFFGLQSLly 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 235 YIIN--MPLFIIDeLHLPEKLAGIMMGTAAGLEIPTMLIAGYYAKRFG-KRFLMRIAAAAGLLFYVGMLtVHTPALLLAL 311
Cdd:COG2807 232 YAVVawLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGdRRPLLLLLGLLGLAGLLGLL-LAPGSLPWLW 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1022699636 312 QLLNAIYIGILAGIGMLYFQDLMPGQAGSAtTLYTNTTRVGWIIAGS---LAGVVAEIW-NYHTVFWIALVMCVLTL 384
Cdd:COG2807 310 AVLLGLGQGGLFPLALTLIGLRARTPAEAA-ALSGMAQSVGYLLAALgplLVGALHDATgSWTAALLLLAALAVLML 385
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
24-299 |
5.00e-06 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 47.98 E-value: 5.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 24 AFLTGIAGALQTPTLSlFLTNEVHARPAMVGFFFTGSAIIGIFVSqFLAGR-SDRKGDRKSLIVfCCLLGVFACLLFAWN 102
Cdd:cd17331 9 IVLYATCYWLQQPVLP-YLTKKLGVDSVVFGYLQTTFSVLQLVGG-PLFGRfGDLFGPRAALVL-SFLSSALSYLLLAFA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 103 RNYFILlfvgvFLSSFGSTANPQMFA---LAREHADRTGREAVMfssilrAQVSLAW----VIGPPLAYALAMGFGFTVM 175
Cdd:cd17331 86 SSVPML-----FLSRLPSVFMHAMQAaqmVVTDLTDPGERAAAL------GRLGLSYgigmVVGSFLGGLLTKKFGEQAA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 176 YLSAAVAFVVCGAMVWFFLPS-----------MRKEPKVATGTLEAPRRNR-RDALLLFIICTLMWGTNSLYIINMPLFI 243
Cdd:cd17331 155 ALVAAVGSLLSIVLVILLIPSntkskrekeakESASPPSVFNLKEILRLLRlPGVAFLLLVKLLSGLPIGMFQSMFSLVA 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1022699636 244 IDELHLPEKLAGIMMGTAAGLEIPTM-LIAGYYAKRFGKRFLMRIAAAAGLLFYVGM 299
Cdd:cd17331 235 MDFFGLTPEENGYLMSYAGVLGMVVQgLLVGPLTKRFGERSLLKLSVALLAIGYLLL 291
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
51-194 |
5.81e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.97 E-value: 5.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 51 AMVGFFFTGSAiIGIFVSQFLAGR-SDRKGDRKSLIVFCCLLGVFACLLfaWNRNYFILLFVGVFLSSFG-STANPQMFA 128
Cdd:cd17489 227 SNAGLFFTVYA-IALLLSRPFSGKlSDRKGPKTVIIPGLLLLALGLLLL--SFAGSPWMLLLAAVLYGLGfGLLFPALQA 303
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1022699636 129 LAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAMGFGFTVMYLSAAVAFVVCGAMVWFFL 194
Cdd:cd17489 304 LAVDLVPPHRRGAAN--GTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
20-382 |
8.04e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 47.60 E-value: 8.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 20 FLIVAFLTGIAGALQTPTLSLFLTnevharpamvgFFFTGSAIIGIFVSQFLAGR-SDRKGDRKSLIVFCCLLGVFACLL 98
Cdd:cd17316 15 FFLIGFVAPVLAAEFSLGLSLLQT-----------GLLFAAGFLGRPIGALLFGYlGDRIGRKKALILTLLLFGLATLLI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 99 -FAWNrnyFILLFVGVFLSSFGSTA-NPQMFALAREHADRTGReavmfsSILRAQVSLAWVIGPPLAYALAMGFG-FTVM 175
Cdd:cd17316 84 gLLPT---PILLLVLRFLQGIGIGGeYPGASTYVAEFAPSKRR------GFALGLLQSGWALGALLAALVASLLIpLLSG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 176 YLSAAVAFVVCGAMVWFFLPSmrkepkvatgtleaprrnRRDALLLFIICTLMWGTNSLYIINMPLFIIDELHLPEKLAG 255
Cdd:cd17316 155 DWGWRILFLIGALPALLALLL------------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSS 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 256 IMMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYV--GMLTVHTPALLLALQLLNAIYIGILAGIGMLYFQDL 333
Cdd:cd17316 217 LYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALplFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAEL 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1022699636 334 MPGQA-GSATTLYTNTTRVGWIIAGSLAGVVAEIWNYHTVFWIALVMCVL 382
Cdd:cd17316 297 FPTEVrATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAI 346
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
25-288 |
1.25e-05 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 46.85 E-value: 1.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 25 FLTGIAGALQtPTLSLFLTNeVHARPAMVGFFFTGSAIIGIFVSQFLAGRSDRKGDRKSLIVFCCLLGV--FACLLFAWN 102
Cdd:pfam12832 10 FYFAALGCLL-PYWGLYLRS-IGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAAvlFLSVLFIPI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 103 RNYFILLFVGVFLSS-FGSTANPQMFALAREHadrTGREAVMFSSIlRAQVSLAWVIgppLAYALAMGFGFTVMYLSAAV 181
Cdd:pfam12832 88 SLTFWWLALLVVLFSfFWNAILPQFEVATLQH---LGEKRKDYGRQ-RLWGSVGFAL---SVFGLGALFDHYSVGLLPSV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 182 AFVVCGA-MVWFFL-----PSMRKEPKVATGTLEAPRRNRRDALLLFIICTLMwgTNSLYIINMPLFI-IDELHLPEKLA 254
Cdd:pfam12832 161 LFYLFAAlMLLSLLlplapPEMEYESKGGSKAVFWNLLKQPEVIIFFLAAFLL--GFSHGPFYTFLFLyLENLGASNTLL 238
|
250 260 270
....*....|....*....|....*....|....
gi 1022699636 255 GIMMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIA 288
Cdd:pfam12832 239 GALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIA 272
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
20-391 |
1.91e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 46.42 E-value: 1.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 20 FLIVAFLTGIAGALQTPTLSLfLTNEVHARPAMVGFFFTGSAIIGIFVSQFLAGRSDRKGDRKSLIVFCCLLGVfACLLF 99
Cdd:cd17504 1 LALAALAVMLVETMLSPALPT-IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTA-GSLLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 100 AWNRNYFILLFvGVFLSSFGSTANPQMFALAREHADRtgREAVMFSSILRAQVSLAWVIGPPLAYALAMGFGFTVMYLSA 179
Cdd:cd17504 79 AFAPNLPVLIA-GRALQGIGGAVFPLAFALVREEFPP--ERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 180 AVAFVVCGAMVWFFLPSMRKEPKVATGTLeaprrnrrdALLLFIICTLMWGTNSLYIINMPLFIidELHLPEKLAGIMMG 259
Cdd:cd17504 156 APVAVLLAALVPLIDLRLLRRRNVLLANI---------TALLAGFGMFMVFQLLPQLLQLPTPT--GFGLGITEAGLLLL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 260 TAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVGMLTVHTpALLLALQLLNAIYIG---ILAGIGMLYFQDLMPG 336
Cdd:cd17504 225 PGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHS-SLWALVVALLLIGIGlglAFASLPNIVVESVPPD 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1022699636 337 QAGSATTLYTNTTRVGWIIAGSLAGVVAEIWN-------------YHTVFWIALVMCVLTLSCLTRIK 391
Cdd:cd17504 304 RTGIATGMNTVLRTIGSAIGPAIAGAILTTYTvsitsggvptegaYVLAFLIGAALALAALLLSLLIP 371
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
20-191 |
3.40e-05 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 45.30 E-value: 3.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 20 FLIVAFLTGIAGALQTPTLSLFLTNEVHARPAMVGFFFTGSAIIGiFVSQFLAGRSDRKGDRKS--LIVFCCLLGVFACL 97
Cdd:cd17390 177 LLLVRFLMGFSVLLFRSNFSLYLEERFDLSPKTIGYLISYSGVLG-ALSGFLVGRILKLYKNNEylLLLHSFILLALSLL 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 98 LFAWNRNYFILLFVGVFLSSFGSTANPQMFALAREHADRTGREAVMFSSilRAQVSLAWVIGPPLAYALAMGFGFTVMYL 177
Cdd:cd17390 256 GLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVG--QSVTSLARILAPLLSGLLQEFSVSGPGLL 333
|
170
....*....|....
gi 1022699636 178 SAAVAFVVCGAMVW 191
Cdd:cd17390 334 GAVLALAAILLMLA 347
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
74-384 |
5.46e-05 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 44.91 E-value: 5.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 74 RSDRKGDRKSLIVFCCL---LGVFACLLFAWNRNYFILLFVGVFLSSFGSTANPQMFALAREHADRTGReavmfSSILRA 150
Cdd:cd17485 58 GLPRLGRRRSWLLPTQLglaLLLLALAFLPPTTNLLAFLGLLFLLNLFSATQDIATDGLAVELLTPEER-----GLGNAA 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 151 QV---SLAWVIGPPLAYALAMGFGFTVMYLSAAVAFVVCGAMVWFFlpsMRKEPKVATGTLEAPRRNRRDALLLFIICTL 227
Cdd:cd17485 133 QVvgyKLGSLLGGGGLLWLYDLIGWQSLLLSLAALYLLLLLPVLFL---RELELPQQPPASERGAALKASLRAFLRRPGT 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 228 MWGT---------NSLYIINMPLFIIDELHLPEKLAGIMMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAA---AAGLLF 295
Cdd:cd17485 210 RWLLlflllyklgEQGALAMLPPFLVDRGFSLSQIGLLSGVGGSLVSIAGSLLGGYLLKRRGRRRLLLLGGllrLLLLGL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 296 YVGMLTVHTPALLLALQLLNAIyIGILAGIGM-----LYFQDLMPGQAGSATTLYTNTTRVGWIIAGSLAGVVAEIWNYH 370
Cdd:cd17485 290 YTLLALGGSGLNWVLLLASLAL-LHLVGGMITtalftLMMDCSQQAQAGTDYTLLATVEVLGKLLFGSLAGFLADHLGYA 368
|
330
....*....|....
gi 1022699636 371 TVFWIALVMCVLTL 384
Cdd:cd17485 369 AAFLLFAILSALSV 382
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-199 |
5.80e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.86 E-value: 5.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 19 AFLIVAFLTGIAGALQTpTLSLFLTNEVHARPAMVGFFFTGSAIIGIFVSQFLAGRSDRKGDR-KSLIVFCCLLGVFACL 97
Cdd:COG2271 185 LALAYFLVYFALYGFLT-WLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrKLVLAIGLLLAALALL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 98 LFAWNRNYFILLFVGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAMGFGFTVMYL 177
Cdd:COG2271 264 LLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTAS--GLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341
|
170 180
....*....|....*....|..
gi 1022699636 178 SAAVAFVVCGAMVWFFLPSMRK 199
Cdd:COG2271 342 LLAALALLAALLALLLLRETRK 363
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
19-194 |
1.37e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 43.78 E-value: 1.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 19 AFLIVAFLTGIAGALQTPTLSLFLTNEVHARPAMVGFFFTGSAIIGIFVSQFLAGR-SDRKGDRKSLIVFCCLLGVfACL 97
Cdd:cd17388 210 GLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPiAKRLGEKRAILLGLAADAL-GFL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 98 LFAWNRNYFiLLFVGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALamgFGFTVMYL 177
Cdd:cd17388 289 LLAFATQGW-MVFPILILLALGGIAGPALQGLLSRQVPENEQGELQ--GVLTSLTSLTSIIGPLLFTGI---FAASPATW 362
|
170 180
....*....|....*....|...
gi 1022699636 178 S------AAVAFVVCGAMVWFFL 194
Cdd:cd17388 363 PglawiiGAALYLICLVLAYRFF 385
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
21-382 |
4.23e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.16 E-value: 4.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 21 LIVAFLTGIAGALQTPTLSLFLTNEvHARPAMVGFFFTGSAIIGIFVSQFLAGRSDRKGDRKSLIVFCCLLGVFACLLFA 100
Cdd:cd17477 2 LLSVALLGLGSGLLLPLLSLRLERE-GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 101 WNRnyFILLFVGVFLSSFGSTAnpqMFALAR----EHADRTGREAVMfsSILRAQVSLAWVIGPPLAyALAMGFGFTvMY 176
Cdd:cd17477 81 TDS--PWVWFLLRFVMGIGLAG---LFVVSEswlnALATNENRGRVL--GLYSTVLGLGFALGPLLL-ALVGTAGAL-PF 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 177 LSAAVAFVVCGAMVWFFLPSMRKEPKVATGTLeapRRNRRDALLLFIICTLMWGTNSLYIINMPLFIIdELHLPEKLAGI 256
Cdd:cd17477 152 LIAAVLLLLALVPLLLTRRAAPEIEEAESISL---RRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGL-RLGLSVAQAAL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 257 MMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVG-MLTVHTPALLLALQLLNAIYIGILAGIGMLY-FQDLM 334
Cdd:cd17477 228 LLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLlPLVPGLPLALLVLLFLWGGAAGPLYTLALALaGDRLP 307
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1022699636 335 PGQAGSATTLYTNTTRVGWIIAGSLAGVVAEIWNYHTVFWIALVMCVL 382
Cdd:cd17477 308 GDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALL 355
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
18-201 |
6.57e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 41.40 E-value: 6.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 18 TAFLIVAFLTGIAGALQtptLSLFLTNEVHARPAMVGFFFTGSAIIGIFVSQFLAGRSDRKGDRKSLIVFCCLLGVFACL 97
Cdd:COG2223 211 SLLYFGTFGSFIGFSSW---LPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 98 LFAWNRNYFILLFVGVFLSSFGSTANPQMFALAREHADRTGREAVmfSSILRAQVSLAWVIGPPLA-YALAMGFGFTVMY 176
Cdd:COG2223 288 LALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAV--YGLVGAAGGLGGFLGPLLFgALLDATGSYTAAF 365
|
170 180
....*....|....*....|....*
gi 1022699636 177 LSAAVAFVVCGAMVWFFLPSMRKEP 201
Cdd:COG2223 366 LVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
63-390 |
7.06e-04 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 41.47 E-value: 7.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 63 IGIFVSQFLAGR-SDRKGDRKSLIVFCCLLGVFACLLFAWNRNYFILLFVGVFLSSFGSTaNPQMFALAREHADRTGReA 141
Cdd:cd17393 45 VGALVAMPLAGRlVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGAL-DVAMNAQGVAVERAYGR-P 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 142 VMfsSILRAQVSLAWVIGPPLAYALA-MGFGFTVMYLSAAVAFVVCGAMVW-FFLPSMRKEPKVATGTLEAPRRNRRDAL 219
Cdd:cd17393 123 IM--SSLHAMWSLGGLAGALLGAAAIgAGVSPGVHLLAAAVLLLLAALVAIrALLPGTGEAAEDRPDGAGKPGFLLPNRL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 220 LLFIICTLMWGTNSLYIIN--MPLFIIDELHLPEKLAGIMMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYV 297
Cdd:cd17393 201 LLLLGLLALAAALAEGAAAdwSALYLRDVLGASAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 298 GMLTVHTPALLLALQLLNAIYIGILAGIGMLYFQDLMPGQAGSATTLYTNTTRVGWIIAGSLAGVVAEIWNYHTVFWIAL 377
Cdd:cd17393 281 LALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGALPGLAAGIAVARVATLGYLGFLVGPPLIGFLADATGLRTAFLVVA 360
|
330
....*....|...
gi 1022699636 378 VMCVLTLSCLTRI 390
Cdd:cd17393 361 LLALLVALLARAV 373
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
20-190 |
7.36e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 41.44 E-value: 7.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 20 FLIVAFLTGIAGALQTPTLSLFLTNEVHARPAMVGFFFTGSAIIGIFVSQFLAGRSDRKGDRKSLIVFCCLLGVFACLLF 99
Cdd:cd17331 212 LLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLL 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 100 AWNRNYFILLFVGVFLSSFGSTANPQMFAL--AREHADRTGreavmfsSIL---RAQVSLAWVIGPPLAYALAMGFGF-T 173
Cdd:cd17331 292 AFVTTVWQLLVLLLPLVIGGSVLYTVITSLltKAVPPEDTG-------TALglsHALFSLVRTVSPTIGGALLQAYGFpS 364
|
170
....*....|....*..
gi 1022699636 174 VMYLSAAVAFVVCGAMV 190
Cdd:cd17331 365 FGLLGAAINGLLTVYLL 381
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
63-383 |
7.71e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 41.11 E-value: 7.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 63 IGIFVSQFLagrSDRKGDRKSLIVFCCLLGVFAcLLFAWNRNYFILLFVGVFLSSFGSTANPQMFALAREHADRTGREAV 142
Cdd:cd17312 53 VGKFISGFL---SDRSNIRRFMSAGLLLSALAN-IFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTV 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 143 MfsSILRAQVSLAWVIGPPLAYALAMGFGF-TVMYLSAAVAFVVcGAMVWFFLpsmRKEPKVAtgtleaprrnrrdaLLL 221
Cdd:cd17312 129 Y--GIWSTSHNFGGILAPILAASLASYYGWrAAFLVPGIVGLVV-AIILFFFL---RDSPPYV--------------WVL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 222 FIICTLMWGTNSLYIINMPLFIIDELHLPEKLAGIMMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVGMLT 301
Cdd:cd17312 189 SLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLAL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 302 VHTPALLLALQLLNAIYIGILAG-----IGMLYFQDLMPGQAGSATTLYTNTT-RVGWIIAGSLAGVVAEIWNYHTVFWI 375
Cdd:cd17312 269 FWFFPHNKLLSIVLLFLIGFFVGgpinlIGGAAAQDIGRKEAAGTATGFVGLFgYLGASLAGLPLGYIIDHYGWSTVFYF 348
|
....*...
gi 1022699636 376 ALVMCVLT 383
Cdd:cd17312 349 LISAALLS 356
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
19-200 |
8.94e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.99 E-value: 8.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 19 AFLIVAFLTGIAGALQTpTLSLFLTNEVHARPAMVGFFFTGSAIiGIFVSQFLAGRSDRKGDRKSLIVFCCLLGVFACLL 98
Cdd:COG0738 215 GGLAIFLYVGAEGAIGD-WLPLYLKDVLGLSEATAALGLSLFWG-GMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLL 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 99 FAWNRNYFILLFVGVFLSSFGSTANPQMFALArehADRTGREAVMFSSILRAQVSLAWVIGPPLAYALAMGFGFTVMYLS 178
Cdd:COG0738 293 ALLAPGPWLALIGLALVGLGLSLMFPTIFSLA---LDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLV 369
|
170 180
....*....|....*....|..
gi 1022699636 179 AAVAFVVCGAMVWFFLPSMRKE 200
Cdd:COG0738 370 PLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
219-390 |
1.27e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 40.61 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 219 LLLFIICTLMWGTNSLYIINMPLFIIDELHLPEKLAGIMMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVG 298
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 299 MLTVHTPALLLALQLLNAIYIGILAGIGMLYFQDLMP-GQAGSATTLYTNTTRVGWIIAGSLAGVVAEIWNYHTVFWIAL 377
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPpEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170
....*....|...
gi 1022699636 378 VMCVLTLSCLTRI 390
Cdd:cd17324 161 VLALLAALLLWRL 173
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
51-119 |
1.69e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 40.14 E-value: 1.69e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 51 AMVGFFFTGSAIIGIFVSQFLAGRSDRKGDRKSLIVFCCLLGVFACLLFAWNRNYFILLFVGVF-LSSFG 119
Cdd:COG2270 52 ALWGYALAIAGLLVALLAPVLGAIADRSGRKKPFLAFFTLLGVLATAALFFVAPGGLWLGLLLFvLANIG 121
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
19-382 |
1.90e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 39.98 E-value: 1.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 19 AFLIVAFLTGIAGALQTPTLSLFLTNEVHARPAMVGFFFTGSAIIGIF----VSQFLAGRSDRKGDRKSLIVFCCLLGVF 94
Cdd:pfam13347 1 GYGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFtdpiVGHIIDRTRTRWGRRRPWLLLSAIILAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 95 ACLLFAWNRN--------YFILLFVGVF-LSSFGSTANPQMFA-LAREHADRT-----GREAVMFSSILRAqvSLAWVIG 159
Cdd:pfam13347 81 SFILLFTPPElgraplfiWLLATYILLRiAYTFFEIPYWSLGPeLTRDYDERTsltsyRSFFSVGGGLLAA--ALAFPLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 160 PPLAYALAMGFGFTVMYLSAAVAFVVCG-AMVWFFLPSMRKEPKVATGTLEAPRRNR--------RDALLLFIICTLMWG 230
Cdd:pfam13347 159 LILGGTGLERKGYRIFALIGAVLMLLGViITAAGTKERVSMRSKEDTGQKEAGSLLDmlkevfrnRAFLILLASFLLAAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 231 TNSLYIINMPLFIIDELHLPeKLAGIMMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVGMLTVHTPALLLA 310
Cdd:pfam13347 239 AMGVLNGLLLYYFRYVLGNG-FAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGPNNTLLF 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 311 LQLLNAIYIGI--LAGIGMLYFQD------LMPGQ--AGSATTLYTNTTRVGWIIAGSLAGVVAEIWNY---------HT 371
Cdd:pfam13347 318 LVLYIIIGFGYgsSFFLPWSMLADvvdygeLRTGKrrEGTFFAMWSFISKLATGVGLGVSGLLLSAFGYnagdsvqspQA 397
|
410
....*....|.
gi 1022699636 372 VFWIALVMCVL 382
Cdd:pfam13347 398 VTAIRLLYAVL 408
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
212-384 |
2.98e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 39.48 E-value: 2.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 212 RRNRRDALLLFIICTLMWGTNSLYIINMPlFIIDELHLPEKLAGIMMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAA 291
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAP-PLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 292 GLLFYVGMLTVHTPALLLALQLLNAIYIGILAGIGMLYFQDLMPGQ-AGSATTLYTNTTRVGWIIAGSLAGVVAEIWNYH 370
Cdd:COG2223 80 LGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDrRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159
|
170
....*....|....
gi 1022699636 371 TVFWIALVMCVLTL 384
Cdd:COG2223 160 NAFLILGILLLVVA 173
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
21-304 |
4.51e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 38.71 E-value: 4.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 21 LIVAFLTGIAGALQTPTLSLFLTNEVHARPAMVGFFFTGSAIiGIFVSQFLAGRSDRKGDRKSLIVFCCLLGVFACLLFA 100
Cdd:cd17473 5 LLASTLTVMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPAL-FIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 101 WNRNYFILLFVGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAmGFGFTVMYLSAA 180
Cdd:cd17473 84 FLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKML--GLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 181 VAFVVcGAMVWFFLPSMRKEPKVATGTLEAPRRnRRDALLLFIICTLMWGTNSLY---IINMPLFIIDELHLPEKLAGIM 257
Cdd:cd17473 161 LALPV-LILVLLFLPEPARKSKSAASPGAATAA-ALPWKRVLPIYFLAFLAMLLFyviPIQLPFLLQERGGGSAALIGLA 238
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1022699636 258 MGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVGMLTVHT 304
Cdd:cd17473 239 LAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASG 285
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
220-305 |
5.16e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.75 E-value: 5.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 220 LLFIICTLMWGTNSLYIINMPLFIIDELHLPEKLAGIMMGTAAGLEIPTMLIAGYYAKRFGKRFLMRIAAAAGLLFYVGM 299
Cdd:cd17329 3 VLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL 82
|
....*.
gi 1022699636 300 LTVHTP 305
Cdd:cd17329 83 GFAHSP 88
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
25-382 |
6.47e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 38.40 E-value: 6.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 25 FLTGIAGALQTPTLSLFLTNEVHARPAMV----GFFFTGSAIIGIFVSQFLAGRSDRKGdRKSLIVFCCLLGVFACLLFA 100
Cdd:cd17391 6 FFTGIGFSLIAPFLPLYIEQLGVTSGGLVelwsGLAFSSTFLVSAIFSPIWGRLADRYG-RKPMLLRASLGMAIVIGLMA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 101 WNRNYFILLF----VGVFlSSFGSTANPQMFALA-REHADRTgreavmFSSILRAQVSLAwVIGPPLAYALAMGFGFTVM 175
Cdd:cd17391 85 FVTNVWQLLIlrllQGVF-SGYVPNATALIASQTpKEKSGWA------LGTLSTGVVAGT-LIGPLLGGFLADLFGIRNV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 176 YLSAAVAFVVCGAMVWFFLPSMRK--EPKVATGTLEAPRRNRRDALLLFIICTLMWGTNSLYIIN--MPLFIIDELHLPE 251
Cdd:cd17391 157 FFITGGLLFLAFLLTLFFVKEDFKpvEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEpiLTLYIRQLMGDAS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 252 KLAGIMMGTAAGLEIPTMLIAGYYAK---RFGKRFLMRIAAAAGLLFYVGMLTVHTPALLLALQLLNAIYIG-ILAGIGM 327
Cdd:cd17391 237 NLAFISGLVFSATGVSSLLSAPRLGKlgdRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGgLLPAINS 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1022699636 328 LyFQDLMPGQAGSATTLYTNTTRVGWIIAGSLAG-VVAEIWNYHTVFWIALVMCVL 382
Cdd:cd17391 317 L-LAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGsAIAAHFGYRAVFVVTALLVLL 371
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
50-364 |
9.06e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 38.11 E-value: 9.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 50 PAMVGFFFTgSAIIGIFVSQFLAGR-SDRKGDRKSLIVFCCLLGVFACLL-FAWNrnyFILLFVGVFLSSFG-STANPQM 126
Cdd:TIGR00895 51 PVQLGFLFS-AGLIGMAFGALFFGPlADRIGRRRVLLWSILLFSVFTLLCaLATN---VTQLLILRFLAGLGlGGLMPNL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 127 FALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAMGFGFTVMYLSAAVAFVVCGAMVWFFLP----------- 195
Cdd:TIGR00895 127 NALVSEYAPKRFRGTAV--GLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPesidflvskrp 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 196 -------------------SMRKEPKVATGTLEAPRR----NRRDALLLFIICTLMWGTNSLYIIN--MPLFIIDELHLP 250
Cdd:TIGR00895 205 etvrrivnaiapqmqaeaqSALPEQKSTQGTKRSVFKalfqGKTARITVLLWLLYFMLLVGVYFLTnwLPKLMVELGFSL 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022699636 251 EKLAGIMMGTAAGLEIPTmLIAGYYAKRFGKRFLMRIAAAAGLLFYVGMLTVHTPALLLALQLLNAIYIGILAGIGMLYF 330
Cdd:TIGR00895 285 SLAATGGALFNFGGVIGS-IIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALM 363
|
330 340 350
....*....|....*....|....*....|....*
gi 1022699636 331 QDLMPGQA-GSATTLYTNTTRVGWIIAGSLAGVVA 364
Cdd:TIGR00895 364 ALFYPTAIrATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| |
