MULTISPECIES: type II toxin-antitoxin system ParD family antitoxin [Pseudoalteromonas]
Protein Classification
type II toxin-antitoxin system ParD family antitoxin( domain architecture ID 10007598)
type II toxin-antitoxin system ParD family antitoxin neutralizes the effect of a ParE family toxin
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| ParD | COG3609 | Transcriptional regulator, contains Arc/MetJ-type RHH (ribbon-helix-helix) DNA-binding domain ... |
7-79 | 1.94e-15 | ||
Transcriptional regulator, contains Arc/MetJ-type RHH (ribbon-helix-helix) DNA-binding domain [Transcription]; : Pssm-ID: 442827 Cd Length: 77 Bit Score: 64.07 E-value: 1.94e-15
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| Name | Accession | Description | Interval | E-value | ||
| ParD | COG3609 | Transcriptional regulator, contains Arc/MetJ-type RHH (ribbon-helix-helix) DNA-binding domain ... |
7-79 | 1.94e-15 | ||
Transcriptional regulator, contains Arc/MetJ-type RHH (ribbon-helix-helix) DNA-binding domain [Transcription]; Pssm-ID: 442827 Cd Length: 77 Bit Score: 64.07 E-value: 1.94e-15
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| ParD_antitoxin | pfam03693 | Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH; ParD is the antitoxin of a ... |
7-65 | 3.66e-04 | ||
Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH; ParD is the antitoxin of a bacterial toxin-antitoxin gene pair. The cognate toxin is ParE in, pfam05016. The family contains several related antitoxins from Cyanobacteria, Proteobacteria and Actinobacteria. Antitoxins of this class carry an N-terminal ribbon-helix-helix domain, RHH, that is highly conserved across all type II bacterial antitoxins, which dimerizes with the RHH domain of a second VapB molecule. A hinge section follows the RHH, with an additional pair of flexible alpha helices at the C-terminus. This C-terminus is the toxin-binding region of the dimer, and so is specific to the cognate toxin, whereas the RHH domain has the specific function of lying across the RNA-binding groove of the toxin dimer and inactivating the active-site - a more general function of all type II antitoxins. Pssm-ID: 281658 Cd Length: 80 Bit Score: 35.59 E-value: 3.66e-04
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| Name | Accession | Description | Interval | E-value | ||
| ParD | COG3609 | Transcriptional regulator, contains Arc/MetJ-type RHH (ribbon-helix-helix) DNA-binding domain ... |
7-79 | 1.94e-15 | ||
Transcriptional regulator, contains Arc/MetJ-type RHH (ribbon-helix-helix) DNA-binding domain [Transcription]; Pssm-ID: 442827 Cd Length: 77 Bit Score: 64.07 E-value: 1.94e-15
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| ParD_antitoxin | pfam03693 | Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH; ParD is the antitoxin of a ... |
7-65 | 3.66e-04 | ||
Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH; ParD is the antitoxin of a bacterial toxin-antitoxin gene pair. The cognate toxin is ParE in, pfam05016. The family contains several related antitoxins from Cyanobacteria, Proteobacteria and Actinobacteria. Antitoxins of this class carry an N-terminal ribbon-helix-helix domain, RHH, that is highly conserved across all type II bacterial antitoxins, which dimerizes with the RHH domain of a second VapB molecule. A hinge section follows the RHH, with an additional pair of flexible alpha helices at the C-terminus. This C-terminus is the toxin-binding region of the dimer, and so is specific to the cognate toxin, whereas the RHH domain has the specific function of lying across the RNA-binding groove of the toxin dimer and inactivating the active-site - a more general function of all type II antitoxins. Pssm-ID: 281658 Cd Length: 80 Bit Score: 35.59 E-value: 3.66e-04
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