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Conserved domains on  [gi|1031820295|ref|WP_064148131|]
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MULTISPECIES: iron ABC transporter permease [Klebsiella]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 33-338 5.34e-78

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 241.13  E-value: 5.34e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295  33 HLGLGARWIAPQTVLQALLEYDPRNFEQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAV 112
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 113 VATSALGLSFGAYpaGRPLTAACGAGLLFGGVMALASAGrGGATPLRITLCGVALSGFASAVTAAILIL-DEQTLLAMRT 191
Cdd:COG0609    81 VLAIVLGGGLSAL--GLPLAAFLGALLAALLVYLLARRG-GGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVF 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 192 WLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGFV 271
Cdd:COG0609   158 WLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFV 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1031820295 272 GLVVPHVVRRLVTEDIRLALPLAAPVGALVLVLADISARTLVAPQELATGAMTALVGAPLFIFIAAR 338
Cdd:COG0609   238 GLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRR 304
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 33-338 5.34e-78

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 241.13  E-value: 5.34e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295  33 HLGLGARWIAPQTVLQALLEYDPRNFEQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAV 112
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 113 VATSALGLSFGAYpaGRPLTAACGAGLLFGGVMALASAGrGGATPLRITLCGVALSGFASAVTAAILIL-DEQTLLAMRT 191
Cdd:COG0609    81 VLAIVLGGGLSAL--GLPLAAFLGALLAALLVYLLARRG-GGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVF 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 192 WLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGFV 271
Cdd:COG0609   158 WLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFV 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1031820295 272 GLVVPHVVRRLVTEDIRLALPLAAPVGALVLVLADISARTLVAPQELATGAMTALVGAPLFIFIAAR 338
Cdd:COG0609   238 GLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRR 304
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 34-338 4.77e-61

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 197.75  E-value: 4.77e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295  34 LGLGARWIAPQTVLQALLEYDPrNFEQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAVV 113
Cdd:pfam01032  10 LFIGAVKISPSDVFSALLGGDD-SLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAALGAV 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 114 ATSALGLSFGAYpaGRPLTAACGAGLLFGGVMALASaGRGGATPLRITLCGVALSGFASAVTAAILIL-DEQTLLAMRTW 192
Cdd:pfam01032  89 LAILLGGSLSLF--ALPLAAFIGALLAALLVYFLSR-GRGGASPLRLILAGIAVSALLSALTSLLLLLlNPEALQSILFW 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 193 LAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGFVG 272
Cdd:pfam01032 166 LMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPIGFVG 245

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1031820295 273 LVVPHVVRRLVTEDIRLALPLAAPVGALVLVLADISARTLVAPQELATGAMTALVGAPLFIFIAAR 338
Cdd:pfam01032 246 LIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
41-338 8.48e-52

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 174.11  E-value: 8.48e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295  41 IAPQTVLQALLEYDPRNFEQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAVVATSALGL 120
Cdd:PRK11228   25 ISAADALNALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTSALSP 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 121 S-FGAYPAGrpLTAACGAGLLFGGVMALASAGRGGATPLRITLCGVALSGFASAVTAAILILDEQTLLAMRTWLAGDLAG 199
Cdd:PRK11228  105 TpFAGYSLA--FIAACGGGLSWLLVMTAGGGWRHTHDRNRLILAGIALSALCMALTRITLLLAEDHAYGIFYWLAGGVSH 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 200 LNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGFVGLVVPHVV 279
Cdd:PRK11228  183 ARWQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPHLA 262

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1031820295 280 RRLVTEDIRLALPLAAPVGALVLVLADISARTLVAPQELATGAMTALVGAPLFIFIAAR 338
Cdd:PRK11228  263 RFWIGYDQRNVLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWLARR 321
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 83-335 1.93e-42

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 147.70  E-value: 1.93e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295  83 VAGLLLQTVIRNPLGEPHILGLNAGASLAVVATSALGLSFGAYPagrpLTAACGAGLLFGGVMALASAGRGGATPLRITL 162
Cdd:cd06550    13 VSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYA----LGAFAFAGALAIALLVLLLASRGGLSPSKLIL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 163 CGVALSGFASAVTAAILILDEQTLLAMRTWLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVN 242
Cdd:cd06550    89 IGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDEDLAKSLGIN 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 243 LVQTRLLGLLAIALLCGAAVAVAGPIGFVGLVVPHVVRRLVTEDIRLALPLAAPVGALVLVLADISARTLVaPQELATGA 322
Cdd:cd06550   169 VNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLL-PSELPVGP 247

                         250
                  ....*....|...
gi 1031820295 323 MTALVGAPLFIFI 335
Cdd:cd06550   248 VTALLGAPYFLYL 260
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 33-338 5.34e-78

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 241.13  E-value: 5.34e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295  33 HLGLGARWIAPQTVLQALLEYDPRNFEQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAV 112
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 113 VATSALGLSFGAYpaGRPLTAACGAGLLFGGVMALASAGrGGATPLRITLCGVALSGFASAVTAAILIL-DEQTLLAMRT 191
Cdd:COG0609    81 VLAIVLGGGLSAL--GLPLAAFLGALLAALLVYLLARRG-GGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVF 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 192 WLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGFV 271
Cdd:COG0609   158 WLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFV 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1031820295 272 GLVVPHVVRRLVTEDIRLALPLAAPVGALVLVLADISARTLVAPQELATGAMTALVGAPLFIFIAAR 338
Cdd:COG0609   238 GLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRR 304
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 34-338 4.77e-61

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 197.75  E-value: 4.77e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295  34 LGLGARWIAPQTVLQALLEYDPrNFEQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAVV 113
Cdd:pfam01032  10 LFIGAVKISPSDVFSALLGGDD-SLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAALGAV 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 114 ATSALGLSFGAYpaGRPLTAACGAGLLFGGVMALASaGRGGATPLRITLCGVALSGFASAVTAAILIL-DEQTLLAMRTW 192
Cdd:pfam01032  89 LAILLGGSLSLF--ALPLAAFIGALLAALLVYFLSR-GRGGASPLRLILAGIAVSALLSALTSLLLLLlNPEALQSILFW 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 193 LAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGFVG 272
Cdd:pfam01032 166 LMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPIGFVG 245

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1031820295 273 LVVPHVVRRLVTEDIRLALPLAAPVGALVLVLADISARTLVAPQELATGAMTALVGAPLFIFIAAR 338
Cdd:pfam01032 246 LIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
41-338 8.48e-52

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 174.11  E-value: 8.48e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295  41 IAPQTVLQALLEYDPRNFEQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAVVATSALGL 120
Cdd:PRK11228   25 ISAADALNALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTSALSP 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 121 S-FGAYPAGrpLTAACGAGLLFGGVMALASAGRGGATPLRITLCGVALSGFASAVTAAILILDEQTLLAMRTWLAGDLAG 199
Cdd:PRK11228  105 TpFAGYSLA--FIAACGGGLSWLLVMTAGGGWRHTHDRNRLILAGIALSALCMALTRITLLLAEDHAYGIFYWLAGGVSH 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 200 LNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGFVGLVVPHVV 279
Cdd:PRK11228  183 ARWQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPHLA 262

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1031820295 280 RRLVTEDIRLALPLAAPVGALVLVLADISARTLVAPQELATGAMTALVGAPLFIFIAAR 338
Cdd:PRK11228  263 RFWIGYDQRNVLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWLARR 321
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
32-338 6.48e-47

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 168.09  E-value: 6.48e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295  32 VHLGLGARWIAPQTVLQALLEYDPRNFEQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLA 111
Cdd:PRK10577   27 LTLTQLSAALPLSQWLQALWGPDADDLEQLLLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPLASPTTLGVAAGAQLA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 112 VVATSALGLSFGAYpaGRPLTAACGAGLLFGGVMALAsaGRGGATPLRITLCGVALSGFASAVTAAILILDEQTLLAMRT 191
Cdd:PRK10577  107 LVLATLFAPALLAL--ASQLAAFAGGLLAAALVFALA--GGKRLSPLRLVLAGMVVSLYLGALTTLLLLFNEQYLQGLFL 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 192 WLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGFV 271
Cdd:PRK10577  183 WGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLLSAAVVSAVGPIGFI 262

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1031820295 272 GLVVPHVVRRLVTEDIRLALPLAAPVGALVLVLADISARTL--VAPQELATGAMTALVGAPLFIFIAAR 338
Cdd:PRK10577  263 GLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLagVGGELLPTGAVTALIGAPLLLWLLPR 331
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 32-338 8.32e-46

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 159.13  E-value: 8.32e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295  32 VHLGLGARWIAPQTVLQALLEYDPRnFEQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLA 111
Cdd:COG4779    39 LALTLGDYPLSPGDVLRALLGEGDP-GASFVVLELRLPRALAALLVGAALGLSGAIFQSLTRNPLASPDIIGITAGASAG 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 112 VVATSALglsFGAYPAGRPLTAACGAGLLFGGVMALAsaGRGGATPLRITLCGVALSGFASAVTAAILI-LDEQTLLAMR 190
Cdd:COG4779   118 AVAAIVV---LGGSGLAVALGALAGGLATALLVYLLA--WRGGVSGYRLILVGIGVSAMLTAVNSYLLTrADLEDAQSAA 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 191 TWLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGF 270
Cdd:COG4779   193 VWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERTRLLLLLVAVALAAVATAAAGPIAF 272

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1031820295 271 VGLVVPHVVRRLVTEDiRLALPLAAPVGALVLVLADISARTLVAPQELATGAMTALVGAPLFIFIAAR 338
Cdd:COG4779   273 VALAAPQIARRLTRSP-GPPLLPSALVGALLLLAADLVAQHLLAPVQLPVGVVTGALGGPYLLWLLIR 339
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
34-338 6.24e-43

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 151.40  E-value: 6.24e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295  34 LGLGARWIAPQTVLQALLEYDpRNFEQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAVV 113
Cdd:PRK10441   28 LLIGAKSLPASVVLEALSGTC-QSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGASFAIV 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 114 ATSALglsFGAY-PAGRPLTAACGAGLLFGGVMALASAGRGGATPLRITLCGVALSGFASAVTAAILILDEQTLLAMRTW 192
Cdd:PRK10441  107 LGAAL---FGYSsAQEQLAMAFAGALVASLIVAFTGSQGGGQLSPVRLTLAGVALAAVLEGLTSGIALLNPDVYDQLRFW 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 193 LAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGFVG 272
Cdd:PRK10441  184 QAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVVGPIAFIG 263

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1031820295 273 LVVPHVVRRLVTEDIRLALPLAAPVGALVLVLADISARTLVaPQELATGAMTALVGAPLFIFIAAR 338
Cdd:PRK10441  264 LMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGRLLV-PGELRVSVVSAFIGAPVLIFLVRR 328
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 83-335 1.93e-42

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 147.70  E-value: 1.93e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295  83 VAGLLLQTVIRNPLGEPHILGLNAGASLAVVATSALGLSFGAYPagrpLTAACGAGLLFGGVMALASAGRGGATPLRITL 162
Cdd:cd06550    13 VSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYA----LGAFAFAGALAIALLVLLLASRGGLSPSKLIL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 163 CGVALSGFASAVTAAILILDEQTLLAMRTWLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVN 242
Cdd:cd06550    89 IGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDEDLAKSLGIN 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 243 LVQTRLLGLLAIALLCGAAVAVAGPIGFVGLVVPHVVRRLVTEDIRLALPLAAPVGALVLVLADISARTLVaPQELATGA 322
Cdd:cd06550   169 VNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLL-PSELPVGP 247

                         250
                  ....*....|...
gi 1031820295 323 MTALVGAPLFIFI 335
Cdd:cd06550   248 VTALLGAPYFLYL 260
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 32-338 9.55e-42

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 148.08  E-value: 9.55e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295  32 VHLGLGARWIAPQTVLQALleydprnfEQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLA 111
Cdd:COG4139    28 LSLCAGEVWIPPTQWLSEA--------WQLFVWQLRLPRTLAAVLVGASLAVSGAVMQALFENPLAEPGLLGISNGAGVG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 112 VVATSALGLSFGAyPAGRPLTAACGAGLLFGGVMALASAGRGGAtplRITLCGVALSGFASA-VTAAILILDEQTLLAMR 190
Cdd:COG4139   100 LVLVVLLGGGLLP-PWLLSLAAIAGALLVTLLLLAFARRRLSNA---RLLLIGVALGIICSAiMTWAVYFSSSLDLRQLM 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 191 TWLAGDLAGLNWSTLQTaLVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGF 270
Cdd:COG4139   176 YWMMGSFGGVDWRQLWL-LLALLPVLLWLCLQGKPLNLLLLGENQARQLGLSVHRWRNLLVLATGLLVGVSVALAGPIGF 254

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1031820295 271 VGLVVPHVVRRLVTEDIRLALPLAAPVGALVLVLADISARTLVAPQELATGAMTALVGAPLFIFIAAR 338
Cdd:COG4139   255 VGLVVPHLLRLLGTTDHRFLLPACALAGAALLLLADIIARLALSSAELPIGVVTATLGAPVFIWLLLR 322
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
63-334 7.58e-41

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 151.53  E-value: 7.58e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295  63 IVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAVVAtsALGLSFGAYPAGRPLTAACGAGLLFG 142
Cdd:PRK10577  393 LLPLRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSGAGLGVVL--ALFLVPGAGFGWLLAAALLGALAALA 470

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 143 GVMALAsaGRGGATPLRITLCGVALSGFASAVTAAILILDEQTLLAMRTWLAGDLAGLNWSTLQTALVPALIGLGVALLI 222
Cdd:PRK10577  471 LILLLA--RRGGFAPERLLLTGIALSALFTALIQLLLASGDPRAAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALLL 548

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 223 APRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGFVGLVVPHVVRRLVTEDIRLALPLAAPVGALVL 302
Cdd:PRK10577  549 RRWLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLM 628

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1031820295 303 VLADISARTLVAPQELATGAMTALVGAPLFIF 334
Cdd:PRK10577  629 VLADWLGRTLLFPYQIPAGLLAALIGAPYFLW 660
btuC PRK09535
cobalamin ABC transporter permease BtuC;
33-335 4.25e-39

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 141.81  E-value: 4.25e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295  33 HLGLGARWIAPQTVLQALLEYDPRNFEQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAV 112
Cdd:PRK09535   61 VLSVGLSLPAPDLEYASPFSFAVPETAQTIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGA 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 113 VATSALGLSFgayPAGRPLTAACGAGLLFGGVMALASagRGGATPL-RITLCGVALSGFASAVTAAILILDEQTLLAMRT 191
Cdd:PRK09535  141 VAAIVLPLAV---PFGLQAAAFAGALVAAFGVYAIAT--ENGRTPVaTLLLAGVAVQTFLGAVISYLLLHSGESLRRAVY 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 192 WLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGFV 271
Cdd:PRK09535  216 WLMGHLHGSTWSDVEVALPVVVVGFVVLLAYARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFV 295

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1031820295 272 GLVVPHVVRRLVTEDIRLALPLAAPVGALVLVLADISARTlvAPQELATGAMTALVGAPLFIFI 335
Cdd:PRK09535  296 GLIVPHVMRLLVGPDHRILLPTSALAGASFLVATDTVARS--GPAEVPVGIVTAALGAPFFLYL 357
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
67-338 6.40e-39

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 140.18  E-value: 6.40e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295  67 RLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAVVATSALGLSFGAYpaGRPLTAACGAGLLFGGVMA 146
Cdd:PRK09777   51 RLPRLLLALFVGAALAVSGVLVQGIVRNPLASPDILGVNHAASLASVGALLLFPSLPVM--WLPLLAFIGGMAGLILLKM 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 147 LAsagrGGATPLRITLCGVALSGFASAVTAAILILDEQTLLAMRTWLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRL 226
Cdd:PRK09777  129 LA----GTHQPMKLALTGVALSALWASLTDYLMLSRPQDINNALLWLTGSLWGRDWSFVKVALPWLILLLPLSLSFCRDL 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 227 NVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGFVGLVVPHVVRRLVTEDIRLALPLAAPVGALVLVLAD 306
Cdd:PRK09777  205 DLLALGDARATTLGVSVPHTQFWALLLAVALTATGVAACGPISFIGLVVPHLMRSLVGGRHRRLLPVSALTGALLLLLAD 284

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1031820295 307 ISARTLVAPQELATGAMTALVGAPLFIFIAAR 338
Cdd:PRK09777  285 LLARIIHPPLELPAGVLTAIIGAPWFFWLLVR 316
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 32-338 1.09e-36

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 134.70  E-value: 1.09e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295  32 VHLGLGARWIAPQTVLQAlleydprnFEQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLA 111
Cdd:PRK03784   31 LSLCAGEQWISPGDWLSP--------RGELFVWQLRLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGLLGVSNGAGVA 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 112 VVATSALGLSFgayPAGRPLTAACGAGLLFGGVMALASAGRGGATPLRITLCGVALSGFASA-VTAAILILDEQTLLAMR 190
Cdd:PRK03784  103 LVAAVLLGQGL---LPPWALSLCAIAGALLITLILLRFARRHRLSTSRLLLAGVALGIICSAlMTWAVYFSTSLDLRQLM 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 191 TWLAGDLAGLNW--STLQTALVPALIGLGvalLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPI 268
Cdd:PRK03784  180 YWMMGGFGGVDWrqSWLMLALLPVLIWLC---CQGRPLNMLALGEISARQLGLPLWFWRNLLVLATGWLVGVSVALAGAI 256

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 269 GFVGLVVPHVVRRLVTEDIRLALPLAAPVGALVLVLADISARTLVAPQELATGAMTALVGAPLFIFIAAR 338
Cdd:PRK03784  257 GFIGLVIPHILRLCGLTDHRVLLPGCALAGASLLLLADIVARLALASAELPIGVVTATLGAPVFIWLLLR 326
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
34-328 1.09e-26

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 107.87  E-value: 1.09e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295  34 LGLGARWIAPQTVLQALLEYDPRNFeQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGA-SLAV 112
Cdd:PRK10440   27 LRSGAVTLETSQVFAALMGDAPRSM-TMVVTEWRLPRVLMALLIGAALGVSGAIFQSLMRNPLGSPDVMGFNTGAwSGVL 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 113 VATSALGLSFGAypagrpLTAACGAGLLFGGVMALASAGRGGATPLRITLCGVALSGFASAVTAAILILDE-QTLLAMRT 191
Cdd:PRK10440  106 VAMVLFGQDLTA------IALAAMAGGIVTSLLVWLLAWRNGIDTFRLIIIGIGVRAMLVAFNTWLLLKASlETALTAGL 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820295 192 WLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGFV 271
Cdd:PRK10440  180 WNAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLLLMLVAVVLTAAATALAGPISFI 259

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1031820295 272 GLVVPHVVRRLvTEDIRLALPLAAPVGALVLVLADISARTLVAPQELATGAMTALVG 328
Cdd:PRK10440  260 ALVAPHIARRL-SGTARWGLTQAALCGALLLLAADLCAQQLFMPYQLPVGVVTVSLG 315
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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