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Conserved domains on  [gi|1031820316|ref|WP_064148150|]
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MULTISPECIES: XRE family transcriptional regulator [Klebsiella]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 18527488)

helix-turn-helix domain-containing protein such as an XRE (Xenobiotic Response Element) family transcriptional regulator containing a cupin-like domain, controls the expression of genes involved in stress response

Gene Ontology:  GO:0003677
PubMed:  10473770|15808743|10556324

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
7-75 4.15e-19

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


:

Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 77.34  E-value: 4.15e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1031820316   7 NLNQRISARIRIERESRGWSLNDLAERAGASRAMIHKIERGESSPTASMLGRLSGAFGISMSTLIARAE 75
Cdd:COG1396     3 TLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGAD 71
COG3837 COG3837
Uncharacterized conserved protein, cupin superfamily [Function unknown];
91-184 9.33e-15

Uncharacterized conserved protein, cupin superfamily [Function unknown];


:

Pssm-ID: 443048 [Multi-domain]  Cd Length: 115  Bit Score: 66.96  E-value: 9.33e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820316  91 RDPQSHYLRRHVSPRSDL-PIDLVQIELPPGSDVPMPAASYAlARQLIWLQQGELVFVEGNTRHEMQAGDCLELGPPNDC 169
Cdd:COG3837     8 PGPEAGRRYRRLGDALGLtRLGVNLITLPPGASSSPYHAHSA-EEEFVYVLEGELTLRIGGEEYVLEPGDSVGFPAGVPH 86

                          90
                  ....*....|....*
gi 1031820316 170 RFINESAETCVYLVV 184
Cdd:COG3837    87 RLRNRGDEPARYLVV 101
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
7-75 4.15e-19

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 77.34  E-value: 4.15e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1031820316   7 NLNQRISARIRIERESRGWSLNDLAERAGASRAMIHKIERGESSPTASMLGRLSGAFGISMSTLIARAE 75
Cdd:COG1396     3 TLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGAD 71
COG3837 COG3837
Uncharacterized conserved protein, cupin superfamily [Function unknown];
91-184 9.33e-15

Uncharacterized conserved protein, cupin superfamily [Function unknown];


Pssm-ID: 443048 [Multi-domain]  Cd Length: 115  Bit Score: 66.96  E-value: 9.33e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820316  91 RDPQSHYLRRHVSPRSDL-PIDLVQIELPPGSDVPMPAASYAlARQLIWLQQGELVFVEGNTRHEMQAGDCLELGPPNDC 169
Cdd:COG3837     8 PGPEAGRRYRRLGDALGLtRLGVNLITLPPGASSSPYHAHSA-EEEFVYVLEGELTLRIGGEEYVLEPGDSVGFPAGVPH 86

                          90
                  ....*....|....*
gi 1031820316 170 RFINESAETCVYLVV 184
Cdd:COG3837    87 RLRNRGDEPARYLVV 101
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 15-70 1.05e-13

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 62.57  E-value: 1.05e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1031820316  15 RIRIERESRGWSLNDLAERAGASRAMIHKIERGESSPTASMLGRLSGAFGISMSTL 70
Cdd:cd00093     3 RLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
15-70 1.28e-13

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 62.54  E-value: 1.28e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1031820316   15 RIRIERESRGWSLNDLAERAGASRAMIHKIERGESSPTASMLGRLSGAFGISMSTL 70
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 16-70 5.82e-12

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 57.94  E-value: 5.82e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1031820316  16 IRIERESRGWSLNDLAERAGASRAMIHKIERGESSPTASMLGRLSGAFGISMSTL 70
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
TIGR00270 TIGR00270
TIGR00270 family protein; [Hypothetical proteins, Conserved]
 16-67 8.12e-07

TIGR00270 family protein; [Hypothetical proteins, Conserved]


Pssm-ID: 129371 [Multi-domain]  Cd Length: 154  Bit Score: 46.83  E-value: 8.12e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1031820316  16 IRIERESRGWSLNDLAERAGASRAMIHKIERGESSPTASMLGRLSGAFGISM 67
Cdd:TIGR00270  74 IRREREKRGWSQEQLAKKIQEKESLIKKIENAEIEPEPKVVEKLEKLLKIKL 125
cupin_XRE_C cd02209
XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain; ...
 97-184 9.38e-07

XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain; This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380339 [Multi-domain]  Cd Length: 90  Bit Score: 45.19  E-value: 9.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820316  97 YLRRHVSPR-SDLPIDLVQIELPPG--SDVPMPAASyalaRQLIWLQQGELVFVEGNTRHEMQAGDCLELGPPNDCRFIN 173
Cdd:cd02209     2 YTYELLSPGlPGRKMEPFLVTLPPGgsGGEPYSHEG----EEFGYVLEGELELTVGGETYVLEAGDSIYFDSDVPHRYRN 77

                          90
                  ....*....|.
gi 1031820316 174 ESAETCVYLVV 184
Cdd:cd02209    78 PGDEPARVLWV 88
PHA01976 PHA01976
helix-turn-helix protein
 20-74 1.22e-06

helix-turn-helix protein


Pssm-ID: 177330 [Multi-domain]  Cd Length: 67  Bit Score: 44.18  E-value: 1.22e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1031820316  20 RESRGWSLNDLAERAGASRAMIHKIERGESSPTASMLGRLSGAFGISMSTLIARA 74
Cdd:PHA01976   11 RNARAWSAPELSRRAGVRHSLIYDFEADKRLPNLKTLLRLADALGVTLDWLCGRC 65
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 115-184 7.77e-06

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 42.25  E-value: 7.77e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1031820316 115 IELPPGSDVPMPAASYAlaRQLIWLQQGELVFVEGNTRHEMQAGDCLELgPPNDC-RFINESAETCVYLVV 184
Cdd:pfam07883   3 VTLPPGESSPPHRHPGE--DEFFYVLEGEGELTVDGEEVVLKAGDSVYF-PAGVPhRFRNTGDEPARLLDV 70
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
7-75 4.15e-19

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 77.34  E-value: 4.15e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1031820316   7 NLNQRISARIRIERESRGWSLNDLAERAGASRAMIHKIERGESSPTASMLGRLSGAFGISMSTLIARAE 75
Cdd:COG1396     3 TLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGAD 71
COG3837 COG3837
Uncharacterized conserved protein, cupin superfamily [Function unknown];
91-184 9.33e-15

Uncharacterized conserved protein, cupin superfamily [Function unknown];


Pssm-ID: 443048 [Multi-domain]  Cd Length: 115  Bit Score: 66.96  E-value: 9.33e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820316  91 RDPQSHYLRRHVSPRSDL-PIDLVQIELPPGSDVPMPAASYAlARQLIWLQQGELVFVEGNTRHEMQAGDCLELGPPNDC 169
Cdd:COG3837     8 PGPEAGRRYRRLGDALGLtRLGVNLITLPPGASSSPYHAHSA-EEEFVYVLEGELTLRIGGEEYVLEPGDSVGFPAGVPH 86

                          90
                  ....*....|....*
gi 1031820316 170 RFINESAETCVYLVV 184
Cdd:COG3837    87 RLRNRGDEPARYLVV 101
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 4-68 1.20e-14

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 65.73  E-value: 1.20e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1031820316   4 IEGNLNQRISARIRIERESRGWSLNDLAERAGASRAMIHKIERGESSPTASMLGRLSGAFGISMS 68
Cdd:COG1813     5 STGELVEDYGERIREAREARGLSQEELAEKLGVSESTIRRIERGEATPSLDTLRKLEKALGISLA 69
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 15-70 1.05e-13

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 62.57  E-value: 1.05e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1031820316  15 RIRIERESRGWSLNDLAERAGASRAMIHKIERGESSPTASMLGRLSGAFGISMSTL 70
Cdd:cd00093     3 RLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
15-70 1.28e-13

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 62.54  E-value: 1.28e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1031820316   15 RIRIERESRGWSLNDLAERAGASRAMIHKIERGESSPTASMLGRLSGAFGISMSTL 70
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
9-75 1.31e-13

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 62.94  E-value: 1.31e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1031820316   9 NQRISARIRIERESRGWSLNDLAERAGASRAMIHKIERGESSPTASMLGRLSGAFGISMSTLIARAE 75
Cdd:COG1476     2 KKKLGNRLKELRKERGLTQEELAELLGVSRQTISAIENGKYNPSLELALKIARALGVSLEELFSLEE 68
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 16-70 5.82e-12

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 57.94  E-value: 5.82e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1031820316  16 IRIERESRGWSLNDLAERAGASRAMIHKIERGESSPTASMLGRLSGAFGISMSTL 70
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 15-74 8.35e-11

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 55.37  E-value: 8.35e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820316  15 RIRIERESRGWSLNDLAERAGASRAMIHKIERGESSPTASMLGRLSGAFGISMSTLIARA 74
Cdd:pfam12844   3 RLRKAREERGLTQEELAERLGISRSQLSAIENGKSVPPAETLYKIAELLGVPANWLLQGE 62
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 9-82 9.77e-11

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 55.80  E-value: 9.77e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1031820316   9 NQRISARIRIERESRGWSLNDLAERAGASRAMIHKIERGESSPTASMLGRLSGAFGISMSTLIARaemQEGKLL 82
Cdd:COG3620    15 DDTLGEALRLMRKELGLSQLPVAELVGVSQSDILRIESGKRDPTVSTLEKIAEALGKELSAVLVV---DDGKLV 85
VapI COG3093
Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense ...
 21-66 1.39e-07

Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense mechanisms];


Pssm-ID: 442327 [Multi-domain]  Cd Length: 87  Bit Score: 47.11  E-value: 1.39e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1031820316  21 ESRGWSLNDLAERAGASRAMIHKIERGESSPTASMLGRLSGAFGIS 66
Cdd:COG3093    19 EPLGLSQTELAKALGVSRQRISEILNGKRAITADTALRLARAFGTS 64
COG1395 COG1395
Predicted transcriptional regulator [Transcription];
6-52 1.90e-07

Predicted transcriptional regulator [Transcription];


Pssm-ID: 441005 [Multi-domain]  Cd Length: 313  Bit Score: 49.84  E-value: 1.90e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1031820316   6 GNLNQRISA-RIRIERESRGWSLNDLAERAGASRAMIHKIERGESSPT 52
Cdd:COG1395   121 GGLYVKIDGeKLRELREERGLSLGELASELGVSRRTISKYERGEMDAS 168
TIGR00270 TIGR00270
TIGR00270 family protein; [Hypothetical proteins, Conserved]
 16-67 8.12e-07

TIGR00270 family protein; [Hypothetical proteins, Conserved]


Pssm-ID: 129371 [Multi-domain]  Cd Length: 154  Bit Score: 46.83  E-value: 8.12e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1031820316  16 IRIERESRGWSLNDLAERAGASRAMIHKIERGESSPTASMLGRLSGAFGISM 67
Cdd:TIGR00270  74 IRREREKRGWSQEQLAKKIQEKESLIKKIENAEIEPEPKVVEKLEKLLKIKL 125
cupin_XRE_C cd02209
XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain; ...
 97-184 9.38e-07

XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain; This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380339 [Multi-domain]  Cd Length: 90  Bit Score: 45.19  E-value: 9.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820316  97 YLRRHVSPR-SDLPIDLVQIELPPG--SDVPMPAASyalaRQLIWLQQGELVFVEGNTRHEMQAGDCLELGPPNDCRFIN 173
Cdd:cd02209     2 YTYELLSPGlPGRKMEPFLVTLPPGgsGGEPYSHEG----EEFGYVLEGELELTVGGETYVLEAGDSIYFDSDVPHRYRN 77

                          90
                  ....*....|.
gi 1031820316 174 ESAETCVYLVV 184
Cdd:cd02209    78 PGDEPARVLWV 88
PHA01976 PHA01976
helix-turn-helix protein
 20-74 1.22e-06

helix-turn-helix protein


Pssm-ID: 177330 [Multi-domain]  Cd Length: 67  Bit Score: 44.18  E-value: 1.22e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1031820316  20 RESRGWSLNDLAERAGASRAMIHKIERGESSPTASMLGRLSGAFGISMSTLIARA 74
Cdd:PHA01976   11 RNARAWSAPELSRRAGVRHSLIYDFEADKRLPNLKTLLRLADALGVTLDWLCGRC 65
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 11-66 2.20e-06

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 43.29  E-value: 2.20e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1031820316  11 RISARIRIERESRGWSLNDLAERAGASRAMIHKIERGE-SSPTASMLGRLSGAFGIS 66
Cdd:pfam13560   1 ELGARLRRLRERAGLSQEALARRLGVSRSTLSRLETGRrGRPSPAVVERLARALGVD 57
PRK04140 PRK04140
transcriptional regulator;
4-53 2.48e-06

transcriptional regulator;


Pssm-ID: 235224 [Multi-domain]  Cd Length: 317  Bit Score: 46.77  E-value: 2.48e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1031820316   4 IEGNLnqrisarIRIERESRGWSLNDLAERAGASRAMIHKIERGESSPTA 53
Cdd:PRK04140  126 IDGDV-------LREAREELGLSLGELASELGVSRRTISKYENGGMNASI 168
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 10-48 3.20e-06

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 43.25  E-value: 3.20e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1031820316  10 QRISARIRIERESRGWSLNDLAERAGASRAMIHKIERGE 48
Cdd:COG1426     4 ETIGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEGD 42
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
105-184 4.49e-06

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 43.68  E-value: 4.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820316 105 RSDLPIDLVQIELPPGSDVPMPaasYALARQLIWLQQGELVFVEGNTRHEMQAGDCLELgPPNDC-RFINESAETCVYLV 183
Cdd:COG1917    18 DGEDELEVVRVTFEPGARTPWH---SHPGEELIYVLEGEGEVEVGGEEYELKPGDVVFI-PPGVPhAFRNLGDEPAVLLV 93


                  .
gi 1031820316 184 V 184
Cdd:COG1917    94 V 94
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 115-184 7.77e-06

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 42.25  E-value: 7.77e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1031820316 115 IELPPGSDVPMPAASYAlaRQLIWLQQGELVFVEGNTRHEMQAGDCLELgPPNDC-RFINESAETCVYLVV 184
Cdd:pfam07883   3 VTLPPGESSPPHRHPGE--DEFFYVLEGEGELTVDGEEVVLKAGDSVYF-PAGVPhRFRNTGDEPARLLDV 70
couple_hipB TIGR03070
transcriptional regulator, y4mF family; Members of this family belong to a clade of ...
 12-67 3.26e-05

transcriptional regulator, y4mF family; Members of this family belong to a clade of helix-turn-helix DNA-binding proteins, among the larger family pfam01381 (HTH_3; Helix-turn-helix). Members are similar in sequence to the HipB protein of E. coli. Genes for members of the seed alignment for this protein family were found to be closely linked to genes encoding proteins related to HipA. The HibBA operon appears to have some features in common with toxin-antitoxin post-segregational killing systems. [Regulatory functions, DNA interactions]


Pssm-ID: 213767 [Multi-domain]  Cd Length: 58  Bit Score: 39.95  E-value: 3.26e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1031820316  12 ISARIRIERESRGWSLNDLAERAGASRAMIHKIERGESSPTASMLGRLSGAFGISM 67
Cdd:TIGR03070   3 IGILVRARRKALGLTQADLADLAGVGLRFIRDLENGKPTVRLDKVLRVLDALGLEL 58
PRK09706 PRK09706
transcriptional repressor DicA; Reviewed
 9-66 4.80e-04

transcriptional repressor DicA; Reviewed


Pssm-ID: 182039 [Multi-domain]  Cd Length: 135  Bit Score: 38.68  E-value: 4.80e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1031820316   9 NQRISARIRIERESRGWSLNDLAERAGASRAMIHKIERGESSPTASMLGRLSGAFGIS 66
Cdd:PRK09706    3 NLTLGQRIRYRRKQLKLSQRSLAKAVKVSHVSISQWERDETEPTGKNLFALAKALQCS 60
PRK09943 PRK09943
HTH-type transcriptional regulator PuuR;
15-78 5.40e-04

HTH-type transcriptional regulator PuuR;


Pssm-ID: 182158 [Multi-domain]  Cd Length: 185  Bit Score: 39.01  E-value: 5.40e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1031820316  15 RIRIERESRGWSLNDLAERAGASRAMIHKIERGESSPTASMLGRLSGAFGISMSTLIARAEMQE 78
Cdd:PRK09943   11 RLSEIRQQQGLSQRRAAELSGLTHSAISTIEQDKVSPAISTLQKLLKVYGLSLSEFFSEPEKPD 74
HTH_26 pfam13443
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ...
 15-71 7.23e-04

Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433211 [Multi-domain]  Cd Length: 63  Bit Score: 36.36  E-value: 7.23e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1031820316  15 RIRIERESRGWSLNDLAERAGASRAMIHKIERGES-SPTASMLGRLSGAFGISMSTLI 71
Cdd:pfam13443   1 KLRKLMADRGISKSDLARATGISRATLSRLRKGKPkRVSLDTLDKICDALGCQPGDLL 58
ManC COG0662
Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];
112-192 7.29e-03

Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 440426 [Multi-domain]  Cd Length: 114  Bit Score: 35.12  E-value: 7.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1031820316 112 LVQIELPPGSDVPMpaASYALARQLIWLQQGELVFVEGNTRHEMQAGDCLELgPPNDC-RFINESAETCVYLVVrlnQSP 190
Cdd:COG0662    29 VKRITVPPGAELSL--HVHPHRDEFFYVLEGTGEVTIGDEEVELKAGDSVYI-PAGVPhRLRNPGDEPLELLEV---QAP 102


                  ..
gi 1031820316 191 SG 192
Cdd:COG0662   103 AY 104
antidote_HigA TIGR02607
addiction module antidote protein, HigA family; Members of this family form a distinct clade ...
 24-67 8.75e-03

addiction module antidote protein, HigA family; Members of this family form a distinct clade within the larger family HTH_3 of helix-turn-helix proteins, described by pfam01381. Members of this clade are strictly bacterial and nearly always shorter than 110 amino acids. This family includes the characterized member HigA, without which the killer protein HigB cannot be cloned. The hig (host inhibition of growth) system is noted to be unusual in that killer protein is uncoded by the upstream member of the gene pair. [Regulatory functions, DNA interactions, Regulatory functions, Protein interactions, Mobile and extrachromosomal element functions, Other]


Pssm-ID: 274228 [Multi-domain]  Cd Length: 78  Bit Score: 33.74  E-value: 8.75e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1031820316  24 GWSLNDLAERAGASRAMIHKIERGESSPTASMLGRLSGAFGISM 67
Cdd:TIGR02607  18 GLSVRALAKALGVSRSTLSRIVNGRAAITADMALRLAKALGTSP 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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