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Conserved domains on  [gi|1032718548|ref|WP_064293035|]
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MULTISPECIES: PepSY domain-containing protein [Aerococcus]

Protein Classification

PepSY and YkoI domain-containing protein( domain architecture ID 12044261)

PepSY and YkoI domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YkoI COG3212
PepSY domain containing protein, regulator of zincin peptidase activity [Posttranslational ...
 169-222 9.70e-08

PepSY domain containing protein, regulator of zincin peptidase activity [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 442445  Cd Length: 66  Bit Score: 47.51  E-value: 9.70e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1032718548 169 ITPKEAMEKALAEHPGeKVKNWELSvDDNGVIHYEIDLTNVD----DVDVNASSGEII 222
Cdd:COG3212     5 ISLEQALEIALARVPG-RVLEVELE-RDDGRLVYEVEILTPDgrvyEVEVDAKTGEVL 60
PepSY pfam03413
Peptidase propeptide and YPEB domain; This region is likely to have an protease inhibitory ...
 88-151 3.26e-03

Peptidase propeptide and YPEB domain; This region is likely to have an protease inhibitory function (personal obs:C Yeats). This model is likely to miss some members of this family as the separation from signal to noise is not clear. The name is derived from Peptidase _ Bacillus subtilis YPEB.


:

Pssm-ID: 427284 [Multi-domain]  Cd Length: 59  Bit Score: 34.96  E-value: 3.26e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1032718548  88 AVSIEDAVNKFNEEtgaqdVKIEEIEFDYEEEFSKHTYQIQGYNAENEWDMHIDPDTGEVLKVE 151
Cdd:pfam03413   1 KISLEQALAIALKA-----VPGAVIEAELEPEDGKLVYEVEVDPDGREYEVYIDAYTGEVLKVE 59
 
Name Accession Description Interval E-value
YkoI COG3212
PepSY domain containing protein, regulator of zincin peptidase activity [Posttranslational ...
 169-222 9.70e-08

PepSY domain containing protein, regulator of zincin peptidase activity [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442445  Cd Length: 66  Bit Score: 47.51  E-value: 9.70e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1032718548 169 ITPKEAMEKALAEHPGeKVKNWELSvDDNGVIHYEIDLTNVD----DVDVNASSGEII 222
Cdd:COG3212     5 ISLEQALEIALARVPG-RVLEVELE-RDDGRLVYEVEILTPDgrvyEVEVDAKTGEVL 60
PepSY pfam03413
Peptidase propeptide and YPEB domain; This region is likely to have an protease inhibitory ...
 169-222 5.36e-04

Peptidase propeptide and YPEB domain; This region is likely to have an protease inhibitory function (personal obs:C Yeats). This model is likely to miss some members of this family as the separation from signal to noise is not clear. The name is derived from Peptidase _ Bacillus subtilis YPEB.


Pssm-ID: 427284 [Multi-domain]  Cd Length: 59  Bit Score: 36.88  E-value: 5.36e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1032718548 169 ITPKEAMEKALAEHPGEKVKnWELsVDDNGVIHYEIDLTNVD---DVDVNASSGEII 222
Cdd:pfam03413   2 ISLEQALAIALKAVPGAVIE-AEL-EPEDGKLVYEVEVDPDGreyEVYIDAYTGEVL 56
PepSY pfam03413
Peptidase propeptide and YPEB domain; This region is likely to have an protease inhibitory ...
 88-151 3.26e-03

Peptidase propeptide and YPEB domain; This region is likely to have an protease inhibitory function (personal obs:C Yeats). This model is likely to miss some members of this family as the separation from signal to noise is not clear. The name is derived from Peptidase _ Bacillus subtilis YPEB.


Pssm-ID: 427284 [Multi-domain]  Cd Length: 59  Bit Score: 34.96  E-value: 3.26e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1032718548  88 AVSIEDAVNKFNEEtgaqdVKIEEIEFDYEEEFSKHTYQIQGYNAENEWDMHIDPDTGEVLKVE 151
Cdd:pfam03413   1 KISLEQALAIALKA-----VPGAVIEAELEPEDGKLVYEVEVDPDGREYEVYIDAYTGEVLKVE 59
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 22-198 6.49e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 37.28  E-value: 6.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032718548   22 GQANDGGDKAKTDQNESSQEVSQETKGETASK-ENNKDQKESKEDNKDQAESNQSSQDQEGIENKEYAVSIEDAVNKFNE 100
Cdd:TIGR00927  665 GEAEQEGETETKGENESEGEIPAERKGEQEGEgEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDE 744

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032718548  101 -ETGAQDVKIEEIEFDYEEEFSKHTYQIQGYNAENEWDMH------IDPDTGEVLKVEAEK--------EANDETKQIEV 165
Cdd:TIGR00927  745 gEGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQagedgeMKGDEGAEGKVEHEGeteagekdEHEGQSETQAD 824

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1032718548  166 TSLITPKEAMEKALAEHPGEkVKNWELSVDDNG 198
Cdd:TIGR00927  825 DTEVKDETGEQELNAENQGE-AKQDEKGVDGGG 856
 
Name Accession Description Interval E-value
YkoI COG3212
PepSY domain containing protein, regulator of zincin peptidase activity [Posttranslational ...
 169-222 9.70e-08

PepSY domain containing protein, regulator of zincin peptidase activity [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442445  Cd Length: 66  Bit Score: 47.51  E-value: 9.70e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1032718548 169 ITPKEAMEKALAEHPGeKVKNWELSvDDNGVIHYEIDLTNVD----DVDVNASSGEII 222
Cdd:COG3212     5 ISLEQALEIALARVPG-RVLEVELE-RDDGRLVYEVEILTPDgrvyEVEVDAKTGEVL 60
PepSY pfam03413
Peptidase propeptide and YPEB domain; This region is likely to have an protease inhibitory ...
 169-222 5.36e-04

Peptidase propeptide and YPEB domain; This region is likely to have an protease inhibitory function (personal obs:C Yeats). This model is likely to miss some members of this family as the separation from signal to noise is not clear. The name is derived from Peptidase _ Bacillus subtilis YPEB.


Pssm-ID: 427284 [Multi-domain]  Cd Length: 59  Bit Score: 36.88  E-value: 5.36e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1032718548 169 ITPKEAMEKALAEHPGEKVKnWELsVDDNGVIHYEIDLTNVD---DVDVNASSGEII 222
Cdd:pfam03413   2 ISLEQALAIALKAVPGAVIE-AEL-EPEDGKLVYEVEVDPDGreyEVYIDAYTGEVL 56
PepSY pfam03413
Peptidase propeptide and YPEB domain; This region is likely to have an protease inhibitory ...
 88-151 3.26e-03

Peptidase propeptide and YPEB domain; This region is likely to have an protease inhibitory function (personal obs:C Yeats). This model is likely to miss some members of this family as the separation from signal to noise is not clear. The name is derived from Peptidase _ Bacillus subtilis YPEB.


Pssm-ID: 427284 [Multi-domain]  Cd Length: 59  Bit Score: 34.96  E-value: 3.26e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1032718548  88 AVSIEDAVNKFNEEtgaqdVKIEEIEFDYEEEFSKHTYQIQGYNAENEWDMHIDPDTGEVLKVE 151
Cdd:pfam03413   1 KISLEQALAIALKA-----VPGAVIEAELEPEDGKLVYEVEVDPDGREYEVYIDAYTGEVLKVE 59
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 22-198 6.49e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 37.28  E-value: 6.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032718548   22 GQANDGGDKAKTDQNESSQEVSQETKGETASK-ENNKDQKESKEDNKDQAESNQSSQDQEGIENKEYAVSIEDAVNKFNE 100
Cdd:TIGR00927  665 GEAEQEGETETKGENESEGEIPAERKGEQEGEgEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDE 744

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032718548  101 -ETGAQDVKIEEIEFDYEEEFSKHTYQIQGYNAENEWDMH------IDPDTGEVLKVEAEK--------EANDETKQIEV 165
Cdd:TIGR00927  745 gEGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQagedgeMKGDEGAEGKVEHEGeteagekdEHEGQSETQAD 824

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1032718548  166 TSLITPKEAMEKALAEHPGEkVKNWELSVDDNG 198
Cdd:TIGR00927  825 DTEVKDETGEQELNAENQGE-AKQDEKGVDGGG 856
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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