|
Name |
Accession |
Description |
Interval |
E-value |
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
33-361 |
1.42e-74 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 237.17 E-value: 1.42e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 33 LRQQASWLSHLVDTMPAGVIVLDGKGMIAKANQIAIDMLGEPLE------------GEKWFSVIQRSFRPHQDDGHEVSL 100
Cdd:COG5000 85 LEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEeligkpleellpELDLAELLREALERGWQEEIELTR 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 101 KDGRLIKLDITALaPEPGQLILMTDLTEtrrlqkrVAHMQRLSALGKMVASLAHQVRTPLSAAMLYAANLGSKRLPEAS- 179
Cdd:COG5000 165 DGRRTLLVRASPL-RDDGYVIVFDDITE-------LLRAERLAAWGELARRIAHEIKNPLTPIQLSAERLRRKLADKLEe 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 180 -----RGSFHTkLMSRLKDLETQVNDMLLFAKsGDQQVVEQVSMQQLLSEVKTGADAMVALNDSELNVSLPEPDIEIMGN 254
Cdd:COG5000 237 dredlERALDT-IIRQVDRLKRIVDEFLDFAR-LPEPQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLAD 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 255 KTALASAIQNLIHNSIQVIGSGAQVHLSAlrdMQDPDYVRISVSDNGPGLDLAQTEKIFEPFYTTKSQGTGLGLAVVSSV 334
Cdd:COG5000 315 RDQLEQVLINLLKNAIEAIEEGGEIEVST---RREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLGLAIVKKI 391
|
330 340
....*....|....*....|....*..
gi 1036092938 335 ASAHQGRVEADNNPQGGAIFSMLLPIS 361
Cdd:COG5000 392 VEEHGGTIELESRPGGGTTFTIRLPLA 418
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
32-361 |
3.99e-69 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 221.26 E-value: 3.99e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 32 DLRQQASWLSHLVDTMPAGVIVLDGKGMIAKANQIAIDML--------GEPL-----EGEKWFSVIQRSFRPHQD-DGHE 97
Cdd:COG3852 1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLglsaeellGRPLaelfpEDSPLRELLERALAEGQPvTERE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 98 VSL--KDGRLIKLDITAlAP------EPGQLILMTDLTETRRLQKRVAHMQRLSALGKMVASLAHQVRTPLsAAMLYAAN 169
Cdd:COG3852 81 VTLrrKDGEERPVDVSV-SPlrdaegEGGVLLVLRDITERKRLERELRRAEKLAAVGELAAGLAHEIRNPL-TGIRGAAQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 170 LGSKRLPEASRGSFhTKLM----SRLKDLetqVNDMLLFAKSGDQQVvEQVSMQQLLSEVktgadAMVALNDSELNVSL- 244
Cdd:COG3852 159 LLERELPDDELREY-TQLIieeaDRLNNL---VDRLLSFSRPRPPER-EPVNLHEVLERV-----LELLRAEAPKNIRIv 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 245 --PEPDI-EIMGNKTALASAIQNLIHNSIQVIGSGAQVHLSA-------LRDMQDPDYVRISVSDNGPGLDLAQTEKIFE 314
Cdd:COG3852 229 rdYDPSLpEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTrverqvtLGGLRPRLYVRIEVIDNGPGIPEEILDRIFE 308
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1036092938 315 PFYTTKSQGTGLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLLPIS 361
Cdd:COG3852 309 PFFTTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLE 355
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
11-361 |
3.79e-53 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 179.61 E-value: 3.79e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 11 FISANQYNPCLLQEEYVGELSDLRQQASWLSHLVDTMPAGVIVLDGKGMIAKANQIAIDMLGEPLEGEKWFSVIQRSFRP 90
Cdd:COG4191 10 LLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 91 HQDDGHEVSLKDGRLIKLDITALAPEPGQLilMTDLTETRRLQKRVAHMQRLSALGKMVASLAHQVRTPLSAAMLYAANL 170
Cdd:COG4191 90 LEALLLLLLAALDAEENAELEELERDITEL--ERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGNAELL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 171 gSKRLPEASRGSFHTKLMSRLKDlETQ-----VNDMLLFAKSGDQQVvEQVSMQQLLSEVKTGADAMVALNDSELNVSLP 245
Cdd:COG4191 168 -RRRLEDEPDPEELREALERILE-GAEraaeiVRSLRAFSRRDEEER-EPVDLNELIDEALELLRPRLKARGIEVELDLP 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 246 EPDIEIMGNKTALASAIQNLIHNSIQVIGSGA--QVHLSALRDmqdPDYVRISVSDNGPGLDLAQTEKIFEPFYTTKS-- 321
Cdd:COG4191 245 PDLPPVLGDPGQLEQVLLNLLINAIDAMEEGEggRITISTRRE---GDYVVISVRDNGPGIPPEVLERIFEPFFTTKPvg 321
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1036092938 322 QGTGLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLLPIS 361
Cdd:COG4191 322 KGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPLA 361
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
65-361 |
4.13e-49 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 168.16 E-value: 4.13e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 65 QIAIDMLGEPLEGEKWFSVIQRSFRPHQDDGHEVSLKDGRLIKLDITALAPEPGQLILMTDLTETRRLQKRVAHMQRLS- 143
Cdd:COG0642 29 LLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANe 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 144 ALGKMVASLAHQVRTPLSAAMLYAANLGSKRLPEASRgsFHTKLMSRLKDLETQVNDMLLFAKSGDQQVV---EQVSMQQ 220
Cdd:COG0642 109 AKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQRE--YLETILRSADRLLRLINDLLDLSRLEAGKLElepEPVDLAE 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 221 LLSEVKTGADAMVALNDSELNVSLPEPDIEIMGNKTALASAIQNLIHNSIQVIGSGAQVHLSALRDmqdPDYVRISVSDN 300
Cdd:COG0642 187 LLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRRE---GDRVRISVEDT 263
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1036092938 301 GPGLDLAQTEKIFEPFYTTKS----QGTGLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLLPIS 361
Cdd:COG0642 264 GPGIPPEDLERIFEPFFRTDPsrrgGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
29-360 |
1.52e-48 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 167.66 E-value: 1.52e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 29 ELSDLRQQASWLSHLVDTMPAGVIVLDGKGMIAKANQIAIDMLG--------------------EPLEGEKWFSVIQRSF 88
Cdd:COG5807 18 EFKLTEDSEFKFKQLFDSILEFVFFIDSKGEILECNDFAEDLYGlsqneyigktfveekcilkdEQLYNKEAFDRIEISY 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 89 rpHQDDGhEVSLKDGRLIKLDITALapepGQLILMTDLTETRRLQKRVAHMQRLSALGKMVASLAHQVRTPLSAAMLYAA 168
Cdd:COG5807 98 --LTKNG-EFDEIIYPIYYKDGVIL----GLITVYRDITKRKEAEDKLLRSEKLSVAGELAAGIAHEIRNPLTSIKGFLQ 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 169 NLGSKRLPEaSRGSFHTKLMSRLKDLETQVNDMLLFAKSgDQQVVEQVSMQQLLSEVKTGADAMVALNDSELNVSLPEPD 248
Cdd:COG5807 171 LLQESREDS-EREEYFNIIISEIDRINTIITELLVLSKP-KKFNFKKLNLNDVLEDVIALLSTEAILKNISIKYDLADDE 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 249 IEIMGNKTALASAIQNLIHNSIQVIGSGAQVHLSALRDmqdPDYVRISVSDNGPGLDLAQTEKIFEPFYTTKSQGTGLGL 328
Cdd:COG5807 249 PVINGDKNQLKQVFINLIKNAIEAMETGGNITIKTYVE---GDFVVISVKDEGIGIPEEVLEKIGEPFFTTKEEGTGLGL 325
|
330 340 350
....*....|....*....|....*....|..
gi 1036092938 329 AVVSSVASAHQGRVEADNNPQGGAIFSMLLPI 360
Cdd:COG5807 326 SICKKIIEEHNGTIEVESKPGKGTTFTIYLPL 357
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
131-361 |
2.42e-48 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 163.54 E-value: 2.42e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 131 RLQKRVAHMQRLSAL-GKMVASLAHQVRTPLSAAMLYAANLGSKR-LPEASRGSFHTKLMSRLKDLETQVNDMLLFAKSG 208
Cdd:COG2205 1 ELEEALEELEELERLkSEFLANVSHELRTPLTSILGAAELLLDEEdLSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 209 DQQVV---EQVSMQQLLSEVKTGADAMVALNDSELNVSLPEPDIEIMGNKTALASAIQNLIHNSIQVIGSGAQVHLSALR 285
Cdd:COG2205 81 SGKLSlelEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 286 DmqdPDYVRISVSDNGPGLDLAQTEKIFEPFY----TTKSQGTGLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLLPIS 361
Cdd:COG2205 161 E---GDGVRISVSDNGPGIPEEELERIFERFYrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLA 237
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
32-361 |
1.56e-47 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 167.84 E-value: 1.56e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 32 DLRQQASWLSHLVDTMPAGVIVLDGKGMIAKANQIAIDMLG---EPLEGEKWFSVI----QRSFRPH-----QDDGHE-- 97
Cdd:COG5809 135 ALRESEEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGisiEELIGKSILELIhsddQENVAAFisqllKDGGIAqg 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 98 ---VSLKDGRLIKLDITALAPEP-----GQLILMTDLTETRRLQKRVAHMQRLSALGKMVASLAHQVRTPLSAA------ 163
Cdd:COG5809 215 evrFWTKDGRWRLLEASGAPIKKngevdGIVIIFRDITERKKLEELLRKSEKLSVVGELAAGIAHEIRNPLTSLkgfiql 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 164 MLYAANlgskrlpEASRGSFHTkLMSRLKDLETQVNDMLLFAKSGDQQVvEQVSMQQLLSEVKT--GADAMvaLNDSELN 241
Cdd:COG5809 295 LKDTID-------EEQKTYLDI-MLSELDRIESIISEFLVLAKPQAIKY-EPKDLNTLIEEVIPllQPQAL--LKNVQIE 363
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 242 VSLPEPDIEIMGNKTALASAIQNLIHNSIQVIGSGAQVHLSALRdmQDPDYVRISVSDNGPGLDLAQTEKIFEPFYTTKS 321
Cdd:COG5809 364 LELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKA--EDDDKVVISVTDEGCGIPEERLKKLGEPFYTTKE 441
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1036092938 322 QGTGLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLLPIS 361
Cdd:COG5809 442 KGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIK 481
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
44-360 |
4.54e-45 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 163.22 E-value: 4.54e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 44 VDTMPAGVIVLDGKGMIAKANQIAIDMLGEPL-------------EGEKWFSVIQRSFR------------PHQDDGHEV 98
Cdd:PRK11360 268 LESIADGVIAIDRQGKITTMNPAAEVITGLQRhelvgkpyselfpPNTPFASPLLDTLEhgtehvdleisfPGRDRTIEL 347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 99 SLKDGRLIKLDITALapepGQLILMTDLTETRRLQKRVAHMQRLSALGKMVASLAHQVRTPLSAAMLYAANLGSKRLPEA 178
Cdd:PRK11360 348 SVSTSLLHNTHGEMI----GALVIFSDLTERKRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPP 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 179 SRGSFHTkLMSRLKDLETQVNDMLLFAKSGdQQVVEQVSMQQLLSEV-----KTGADAMVALNdSELNVSLPEpdieIMG 253
Cdd:PRK11360 424 SQEYLSV-VLREVDRLNKVIDQLLEFSRPR-ESQWQPVSLNALVEEVlqlfqTAGVQARVDFE-TELDNELPP----IWA 496
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 254 NKTALASAIQNLIHNSIQVIGSGAQVHLSALRdmQDPDYVRISVSDNGPGLDLAQTEKIFEPFYTTKSQGTGLGLAVVSS 333
Cdd:PRK11360 497 DPELLKQVLLNILINAVQAISARGKIRIRTWQ--YSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQR 574
|
330 340
....*....|....*....|....*..
gi 1036092938 334 VASAHQGRVEADNNPQGGAIFSMLLPI 360
Cdd:PRK11360 575 IINAHGGDIEVESEPGVGTTFTLYLPI 601
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
21-361 |
2.35e-44 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 157.41 E-value: 2.35e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 21 LLQEEYVGELSDLRQQASWLSHLVDTMPAGVIVLDGKGMIAKANQIAIDMLGEPLEGEKWFSVIQRSFRPHQDDGHEVSL 100
Cdd:COG5002 50 LLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 101 KDGRLIKLDITALAPEPGQLILMTDLTETRRLQKrvahMQRlsalgKMVASLAHQVRTPLSAAMLYAANL--GSKRLPEA 178
Cdd:COG5002 130 LLGRLSLRLSALLLGLLLLAAVERDITELERLEQ----MRR-----EFVANVSHELRTPLTSIRGYLELLldGAADDPEE 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 179 SRgSFHTKLMSRLKDLETQVNDMLLFAK--SGDQQV-VEQVSMQQLLSEVKTGADAMVALNDSELNVSLPEPDIEIMGNK 255
Cdd:COG5002 201 RR-EYLEIILEEAERLSRLVNDLLDLSRleSGELKLeKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDP 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 256 TALASAIQNLIHNSIQVIGSGAQVHLSALRDmqdPDYVRISVSDNGPGLDLAQTEKIFEPFYTT------KSQGTGLGLA 329
Cdd:COG5002 280 DRLEQVLTNLLDNAIKYTPEGGTITVSLREE---DDQVRISVRDTGIGIPEEDLPRIFERFYRVdksrsrETGGTGLGLA 356
|
330 340 350
....*....|....*....|....*....|..
gi 1036092938 330 VVSSVASAHQGRVEADNNPQGGAIFSMLLPIS 361
Cdd:COG5002 357 IVKHIVEAHGGRIWVESEPGKGTTFTITLPLA 388
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
33-361 |
6.40e-42 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 152.96 E-value: 6.40e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 33 LRQQASWLSHLVDTMPAGVIVLDGKGMIAKANQIAIDMLG---EPLEGEKWFSVI-----QRSFRPHQDD---------G 95
Cdd:COG5805 152 LQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGaprEELIGKNLLELLhpcdkEEFKERIESItevwqefiiE 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 96 HEVSLKDGRLIKLD------ITALAPEPGQLILMTDLTETRRLQKRVAHMQRLSALGKMVASLAHQVRTPLSA-----AM 164
Cdd:COG5805 232 REIITKDGRIRYFEavivplIDTDGSVKGILVILRDITEKKEAEELMARSEKLSIAGQLAAGIAHEIRNPLTSikgflQL 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 165 LyaanlgskrLPEASRGSFHTKLM-SRLKDLETQVNDMLLFAKSgDQQVVEQVSMQQLLSEVKT--GADAMvaLNDSELN 241
Cdd:COG5805 312 L---------QPGIEDKEEYFDIMlSELDRIESIISEFLALAKP-QAVNKEKENINELIQDVVTllETEAI--LHNIQIR 379
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 242 VSLPEPDIEIMGNKTALASAIQNLIHNSIQVIGSGAQVHLSAlrdMQDPDYVRISVSDNGPGLDLAQTEKIFEPFYTTKS 321
Cdd:COG5805 380 LELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHT---EEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKE 456
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1036092938 322 QGTGLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLLPIS 361
Cdd:COG5805 457 KGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPLS 496
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
120-361 |
1.08e-31 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 124.48 E-value: 1.08e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 120 LILMTDLTETRRLQKRVA--HMQRLSALGKMVASLAHQVRTPLSAAMLYAANLGSKRLPEASRGSFHTkLMSRLKDLETQ 197
Cdd:COG5808 214 LLQYNLLKRKTLLERVIQeiNTQKLELIGTFAASTAHEIRNPLTSIKGFIQLLQEKYPELEDQKYFDI-IQEEIQRINQI 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 198 VNDMLLFAKSGDQQVvEQVSMQQLLSEVKTGADAMVALNDSELNVSLPEPDIEIMGNKTALASAIQNLIHNSIQVIGSGA 277
Cdd:COG5808 293 VSEFLVLGKPTAKKL-ELDDLNELIEEILSIIDSEANLKNIRVEKQSLDEPLHIKCDKDRIKQVLLNLIKNAIEAMKEGG 371
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 278 QVHLSAlrdMQDPDYVRISVSDNGPGLDLAQTEKIFEPFYTTKSQGTGLGLAVVSSVASAHQGRVEADNNPQGGAIFSML 357
Cdd:COG5808 372 KLTISI---ENDDEKAVIEVIDNGEGIPEDIIDEIFEPFVTTKEGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIR 448
|
....
gi 1036092938 358 LPIS 361
Cdd:COG5808 449 LPLK 452
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
21-361 |
1.13e-31 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 124.90 E-value: 1.13e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 21 LLQEEYVGELSDLRQQASWLSHLVDTMPAGVIVLDGKGMIAKANQIAIDMLGEPLEGEKWFSVIQRSFRPHQDDGHEVSL 100
Cdd:COG4251 151 LLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLL 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 101 KDGRLIKLDITALAPEPGQLILMTDLTE------TRRLQKRVAHMQRLSA-LGKMVASLAHQVRTPLSAAMLYAANLGSK 173
Cdd:COG4251 231 LLLLLVLLLLLILLLLLLILVLELLELRleleelEEELEERTAELERSNEeLEQFAYVASHDLREPLRKISGFSQLLEED 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 174 ---RLPEASRGSFHtKLMSRLKDLETQVNDMLLFAKSGDQQVV-EQVSMQQLLSEVKTGADAMVALNDSELNVslpEPDI 249
Cdd:COG4251 311 ygdKLDEEGREYLE-RIRDAAERMQALIDDLLAYSRVGRQELEfEPVDLNELLEEVLEDLEPRIEERGAEIEV---GPLP 386
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 250 EIMGNKTALASAIQNLIHNSIQVIGSG--AQVHLSALRDmqdPDYVRISVSDNGPGLDLAQTEKIFEPFYTTKSQ----G 323
Cdd:COG4251 387 TVRGDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAERE---GGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRdeyeG 463
|
330 340 350
....*....|....*....|....*....|....*...
gi 1036092938 324 TGLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLLPIS 361
Cdd:COG4251 464 TGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKA 501
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
122-359 |
1.62e-30 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 120.36 E-value: 1.62e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 122 LMTDLTETRRLQKRVAHMQRLSALGKMVASLAHQVRTPLSAAMLYAANLGSKRLPEASRGSFHtKLMsrLKDL---ETQV 198
Cdd:COG5806 178 LIENLIENILLRKELQRAEKLEVVSELAASIAHEVRNPLTVVRGFIQLLQEPELSDEKRKQYI-RIA--LEELdraEAII 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 199 NDMLLFAKSGDQQVvEQVSMQQLLSEVKTGADAMVALNDSELNVSLpEPDIEIMGNKTALASAIQNLIHNSIQVIGSGAQ 278
Cdd:COG5806 255 TDYLTFAKPQPEKL-EKIDVSEELEHVIDVLSPYANMNNVEIQTEL-EPGLYIEGDRQKLQQCLINIIKNGIEAMPNGGT 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 279 VHLSALRDMqdpDYVRISVSDNGPGLDLAQTEKIFEPFYTTKSQGTGLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLL 358
Cdd:COG5806 333 LTIDVSIDK---NKVIISIKDTGVGMTKEQLERLGEPYFSTKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITL 409
|
.
gi 1036092938 359 P 359
Cdd:COG5806 410 P 410
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
127-361 |
1.95e-30 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 122.86 E-value: 1.95e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 127 TETRRLQKRVAHMQRLSALGKMVASLAHQVRTPLSAAMLYAaNLGSKRLPEASRGSFHTKLMS----RLKDLetqVNDML 202
Cdd:PRK13837 432 TERDALERRLEHARRLEAVGTLASGIAHNFNNILGAILGYA-EMALNKLARHSRAARYIDEIIsagaRARLI---IDQIL 507
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 203 LFAKSGDQqVVEQVSMQQLLSEVKtgadamvalndSELNVSLPEP----------DIEIMGNKTALASAIQNLIHNSIQV 272
Cdd:PRK13837 508 AFGRKGER-NTKPFDLSELVTEIA-----------PLLRVSLPPGveldfdqdqePAVVEGNPAELQQVLMNLCSNAAQA 575
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 273 IGSGAQVHLSALR------------DMQDPDYVRISVSDNGPGLDLAQTEKIFEPFYTTKSQGTGLGLAVVSSVASAHQG 340
Cdd:PRK13837 576 MDGAGRVDISLSRaklrapkvlshgVLPPGRYVLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAG 655
|
250 260
....*....|....*....|.
gi 1036092938 341 RVEADNNPQGGAIFSMLLPIS 361
Cdd:PRK13837 656 YIDVQSTVGRGTRFDVYLPPS 676
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
258-358 |
5.09e-29 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 108.07 E-value: 5.09e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 258 LASAIQNLIHNSIQVIGSGAQVHLSALrdmQDPDYVRISVSDNGPGLDLAQTEKIFEPFYTTK----SQGTGLGLAVVSS 333
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLR---QEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDksreGGGTGLGLAIVRR 77
|
90 100
....*....|....*....|....*
gi 1036092938 334 VASAHQGRVEADNNPQGGAIFSMLL 358
Cdd:cd00075 78 IVEAHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
253-361 |
1.53e-27 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 104.65 E-value: 1.53e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 253 GNKTALASAIQNLIHNSIQVIGSGAQVHLSALRDmqdPDYVRISVSDNGPGLDLAQTEKIFEPFYTTK-----SQGTGLG 327
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERD---GDHVEITVEDNGPGIPPEDLEKIFEPFFRTDkrsrkIGGTGLG 77
|
90 100 110
....*....|....*....|....*....|....
gi 1036092938 328 LAVVSSVASAHQGRVEADNNPQGGAIFSMLLPIS 361
Cdd:smart00387 78 LSIVKKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
130-365 |
1.28e-26 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 110.26 E-value: 1.28e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 130 RRLQKRVAHMQRLSALGKMVASLAHQVRTPLSAAMLYAANLGsKRLPEASRGSFHTKLMSRLKD-LETQVNDMLLFAKSG 208
Cdd:PRK10364 222 QLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFA-ERAPAGGEAHQLAQVMAKEADrLNRVVSELLELVKPT 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 209 D---QQVVEQVSMQQLLSEVKTGADAmvalNDSELNVSLPEPDIEIMGNKTALASAIQNLIHNSIQVIGSGAQVHLSALR 285
Cdd:PRK10364 301 HlalQAVDLNDLINHSLQLVSQDANS----REIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASE 376
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 286 DmqdPDYVRISVSDNGPGLDLAQTEKIFEPFYTTKSQGTGLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLLPISVTSK 365
Cdd:PRK10364 377 S---GAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITRR 453
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
132-364 |
4.12e-25 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 105.78 E-value: 4.12e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 132 LQKRVAHMQRLsalgkmVASLAHQVRTPLSAAMLyAANLGSKRLPEASRgsfHTKLMSRLKDLETQVNDMLLFAKsgdQQ 211
Cdd:PRK09470 236 LERMMTSQQRL------LSDISHELRTPLTRLQL-ATALLRRRQGESKE---LERIETEAQRLDSMINDLLVLSR---NQ 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 212 V-----VEQVSMQQLLSEVktgadamvaLNDSE---------LNVSLPEPDIEIMGNKTALASAIQNLIHNSIQVIGSGA 277
Cdd:PRK09470 303 QknhleRETFKANSLWSEV---------LEDAKfeaeqmgksLTVSAPPGPWPINGNPNALASALENIVRNALRYSHTKI 373
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 278 QVHLSAlrdmqDPDYVRISVSDNGPGLDLAQTEKIFEPFYTT------KSQGTGLGLAVVSSVASAHQGRVEADNNPQGG 351
Cdd:PRK09470 374 EVAFSV-----DKDGLTITVDDDGPGVPEEEREQIFRPFYRVdeardrESGGTGLGLAIVENAIQQHRGWVKAEDSPLGG 448
|
250
....*....|...
gi 1036092938 352 AIFSMLLPISVTS 364
Cdd:PRK09470 449 LRLTIWLPLYKRS 461
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
22-361 |
1.62e-24 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 103.39 E-value: 1.62e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 22 LQEEYVGELSDLRQQASWLSHlvdTMPAGVIVLDGKGMIAKANQIAIDMLGEPLEGEKWFSVIQRSFRPHQDDGhEVSLK 101
Cdd:COG3290 71 LLLKLLEEIARLVEEREAVLE---SIREGVIAVDRDGRITLINDAARRLLGLDAIGRPIDEVLAEVLETGERDE-EILLN 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 102 DGRLI--KLDITALAPEPGQLILMTDLTETRRLQKRVAHMQRLS-ALGKM----------VASLAHQVRTplSAAMLYAA 168
Cdd:COG3290 147 GRVLVvnRVPIRDDGRVVGAVATFRDRTELERLEEELEGVKELAeALRAQrhdfrnhlhtISGLLQLGEY--DEALEYID 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 169 NLgskrlpEASRGSFHTKLMSRLKDLETqvnDMLLFAKSgdqqvveqvsmqqllsevktgADAmvalndSELNVSL---- 244
Cdd:COG3290 225 EI------SEELQELIDSLLSRIGNPVL---AALLLGKA---------------------ARA------RERGIDLtidi 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 245 --PEPDIEImgNKTALASAIQNLIHNSI----QVIGSGAQVHLSAlrdMQDPDYVRISVSDNGPGLDLAQTEKIFEPFYT 318
Cdd:COG3290 269 dsDLPDLPL--SDTDLVTILGNLLDNAIeaveKLPEEERRVELSI---RDDGDELVIEVEDSGPGIPEELLEKIFERGFS 343
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1036092938 319 TK-SQGTGLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLLPIS 361
Cdd:COG3290 344 TKlGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKE 387
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
128-361 |
3.98e-24 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 103.00 E-value: 3.98e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 128 ETRRLQKRVAHMqRLSALGK-----MVASLAHQVRTPLsAAMLYAANLGSKRLPEASRGSFHTKLMSRLKDLETQVNDML 202
Cdd:PRK11100 235 ELRELAQALESM-RVKLEGKayveqYVQTLTHELKSPL-AAIRGAAELLQEDPPPEDRARFTGNILTQSARLQQLIDRLL 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 203 LFAK---SGDQQVVEQVSMQQLLSEVKTGADAMVALNDSELNVSLPepDIEIMGNKTALASAIQNLIHNSIQVIGSGAQV 279
Cdd:PRK11100 313 ELARleqRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPD--DARVLGDPFLLRQALGNLLDNAIDFSPEGGTI 390
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 280 HLSAlrdMQDPDYVRISVSDNGPGL-DLAQtEKIFEPFYT-----TKSQGTGLGLAVVSSVASAHQGRVEADNNPQGGAI 353
Cdd:PRK11100 391 TLSA---EVDGEQVALSVEDQGPGIpDYAL-PRIFERFYSlprpaNGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVL 466
|
....*...
gi 1036092938 354 FSMLLPIS 361
Cdd:PRK11100 467 ATLTLPRH 474
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
258-359 |
7.32e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 94.31 E-value: 7.32e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 258 LASAIQNLIHNSIQVigSGAQVHLSAlrdMQDPDYVRISVSDNGPGLDLAQTEKIFEPFY------TTKSQGTGLGLAVV 331
Cdd:cd16949 1 LARALENVLRNALRY--SPSKILLDI---SQDGDQWTITITDDGPGVPEDQLEQIFLPFYrvdsarDRESGGTGLGLAIA 75
|
90 100
....*....|....*....|....*...
gi 1036092938 332 SSVASAHQGRVEADNNPQGGAIFSMLLP 359
Cdd:cd16949 76 ERAIEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
148-359 |
1.03e-23 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 102.81 E-value: 1.03e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 148 MVASLAHQVRTPLSAA-------MLYAANLGSKRLPEASRGSFHTKLMSRLkdletqVNDMLLFAK--SGDQQVVEQvsm 218
Cdd:PRK10490 667 LLAALSHDLRTPLTVLfgqaeilTLDLASEGSPHARQASEIRQQVLNTTRL------VNNLLDMARiqSGGFNLRKE--- 737
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 219 QQLLSEVKTGADAMVA--LNDSELNVSLPEPDIEIMGNKTALASAIQNLIHNSIQVIGSGAQVHLSAlrdMQDPDYVRIS 296
Cdd:PRK10490 738 WLTLEEVVGSALQMLEpgLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDA---HVEGERLQLD 814
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1036092938 297 VSDNGPGLDLAQTEKIFEPFYTTKSQ----GTGLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLLP 359
Cdd:PRK10490 815 VWDNGPGIPPGQEQLIFDKFARGNKEsaipGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLP 881
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
253-359 |
1.25e-23 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 93.97 E-value: 1.25e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 253 GNKTALASAIQNLIHNSIQVIGSGAQVHLSalrdMQDPDYVRISVSDNGPGLDLAQTEKIFEPFYT---TKSQGTGLGLA 329
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVT----LSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|
gi 1036092938 330 VVSSVASAHQGRVEADNNPQGGAIFSMLLP 359
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
264-359 |
6.94e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 88.99 E-value: 6.94e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 264 NLIHNSIQVI-GSGAQVHLSALRDMQ-DPDYVRISVSDNGPGLDLAQTEKIFEPFYTTKSQGTGLGLAVVSSVASAHQGR 341
Cdd:cd16920 7 NLVRNGIEAMsEGGCERRELTIRTSPaDDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSIIEAHGGR 86
|
90
....*....|....*...
gi 1036092938 342 VEADNNPQGGAIFSMLLP 359
Cdd:cd16920 87 LSVESPAGGGATFQFTLP 104
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
264-360 |
2.83e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 87.48 E-value: 2.83e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 264 NLIHNSIQVIGSGAQVhlsALRDMQDPDYVRISVSDNGPGLDLAQTEKIFEPFYTTK--SQGTGLGLAVVSSVASAHQGR 341
Cdd:cd16943 10 NLLVNAAQAMEGRGRI---TIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKpvGEGTGLGLSLSYRIIQKHGGT 86
|
90
....*....|....*....
gi 1036092938 342 VEADNNPQGGAIFSMLLPI 360
Cdd:cd16943 87 IRVASVPGGGTRFTIILPI 105
|
|
| nifL_nitrog |
TIGR02938 |
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ... |
33-360 |
1.84e-20 |
|
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]
Pssm-ID: 131984 [Multi-domain] Cd Length: 494 Bit Score: 92.66 E-value: 1.84e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 33 LRQQASWLSHLVDTMPAGVIVLDGKGMIAKANQ----IAIDM----------------LGEPLE---------------- 76
Cdd:TIGR02938 125 VANQKLLIESVVDAAPVAFVLLDPTGRVILDNQeykkLATDLrvkepahtvldllreaWREALAenwpqqlafsnrearf 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 77 ------GEKWFSVIQRSFRPHQDDGHevslkdgrliklDITALAPEPGQLILMTDLTETRRLQKR---------VAHMQR 141
Cdd:TIGR02938 205 drgggrPARWLSCTGSVIGMESDCAD------------SFFCAAEQPYLLLTIADISNLREEQERarlsalqalMAEEER 272
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 142 LSALGKMVASLAHQVRTPL---SAAMLYAANLGSKRLPEASRGSFHTKLMSRLKDLETQVNDMllfaKSGDQQVVEQVSM 218
Cdd:TIGR02938 273 LEAIRETLSAAIHRLQGPMnliSAAISVLQRRGDDAGNPASAAMLQQALSAGREHMEALRQVI----PQSPQEIVVPVNL 348
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 219 QQLLSEVKT-GADAMVA---LNDSELNVSLPEpdieIMGNKTALASAIQNLIHNSIQVIgSGAQVH------LSALRDmq 288
Cdd:TIGR02938 349 NQILRDVITlSTPRLLAagiVVDWQPAATLPA----ILGRELQLRSLFKALVDNAIEAM-NIKGWKrrelsiTTALNG-- 421
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1036092938 289 dpDYVRISVSDNGPGLDLAQTEKIFEPFYTTKS---QGTGLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLLPI 360
Cdd:TIGR02938 422 --DLIVVSILDSGPGIPQDLRYKVFEPFFTTKGgsrKHIGMGLSVAQEIVADHGGIIDLDDDYSEGCRIIVEFRV 494
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
140-359 |
2.43e-20 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 92.07 E-value: 2.43e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 140 QRLSALGkmvASLAHQVRTPLSAAMLYAANLGSK-RLPEASRGSFHTKLmSRLKDLETQVNDMLLFAKSGDQQVVEQVSM 218
Cdd:TIGR01386 239 QRLSQFS---ADLAHELRTPLTNLLGQTQVALSQpRTGEEYREVLESNL-EELERLSRMVSDMLFLARADNGQLALERVR 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 219 QQLLSEVKTGADAMVALNDSELNVSLPEPDIEIMGNKTALASAIQNLIHNSIQVIGSGAQVHLSALRdmqDPDYVRISVS 298
Cdd:TIGR01386 315 LDLAAELAKVAEYFEPLAEERGVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIER---RSDEVRVSVS 391
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1036092938 299 DNGPGLDLAQTEKIFEPFY------TTKSQGTGLGLAVVSSVASAHQGRVEADnNPQGGAIFSMLLP 359
Cdd:TIGR01386 392 NPGPGIPPEHLSRLFDRFYrvdparSNSGEGTGLGLAIVRSIMEAHGGRASAE-SPDGKTRFILRFP 457
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
148-361 |
9.04e-19 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 87.27 E-value: 9.04e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 148 MVASLAHQVRTPLSaamlyaanlgskrlpeasRGSFHTKLMSR----LKD-LETQVNDM-------LLFAKSGDQQVVEQ 215
Cdd:PRK09467 232 LMAGVSHDLRTPLT------------------RIRLATEMMSEedgyLAEsINKDIEECnaiieqfIDYLRTGQEMPMEM 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 216 VSMQQLLSEVktgadAMVALN-DSELNVSLPEPDIEIMGNKTALASAIQNLIHNSIQViGSGaQVHLSALRDMQdpdYVR 294
Cdd:PRK09467 294 ADLNALLGEV-----IAAESGyEREIETALQPGPIEVPMNPIAIKRALANLVVNAARY-GNG-WIKVSSGTEGK---RAW 363
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1036092938 295 ISVSDNGPGLDLAQTEKIFEPFytTK------SQGTGLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLLPIS 361
Cdd:PRK09467 364 FQVEDDGPGIPPEQLKHLFQPF--TRgdsargSSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPLT 434
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
258-359 |
1.59e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 79.78 E-value: 1.59e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 258 LASAIQNLIHNSIQVigSGAQVHLSALRDMqdpDYVRISVSDNGPGLDLAQTEKIFEPF------YTTKSQGTGLGLAVV 331
Cdd:cd16939 1 MARALDNLLRNALRY--AHRTVRIALLVSG---GRLTLIVEDDGPGIPAAARERVFEPFvrldpsRDRATGGFGLGLAIV 75
|
90 100
....*....|....*....|....*...
gi 1036092938 332 SSVASAHQGRVEADNNPQGGAIFSMLLP 359
Cdd:cd16939 76 HRVALWHGGHVECDDSELGGACFRLTWP 103
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
248-351 |
3.04e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 79.37 E-value: 3.04e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 248 DIEIMGNKTALASAIQNLIHNSIQVIGSGAQVHLSalrdMQDPDYVRISVSDNGPGLDLAQTEKIFEPFY---TTKSQGT 324
Cdd:cd16940 4 DIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIK----LSADDGAVIRVEDNGPGIDEEELEALFERFYrsdGQNYGGS 79
|
90 100
....*....|....*....|....*..
gi 1036092938 325 GLGLAVVSSVASAHQGRVEADNNPQGG 351
Cdd:cd16940 80 GLGLSIVKRIVELHGGQIFLGNAQGGG 106
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
262-359 |
9.50e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 77.89 E-value: 9.50e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 262 IQNLIHNSIQVIGSGAQVHLSAlrdMQDPDYVRISVSDNGPGLDLAQTEKIFEPFYTTKSQ------GTGLGLAVVSSVA 335
Cdd:cd16946 9 FVNLLENSLRYTDTGGKLRIRA---AQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSrnrasgGSGLGLAICHNIA 85
|
90 100
....*....|....*....|....
gi 1036092938 336 SAHQGRVEADNNPQGGAIFSMLLP 359
Cdd:cd16946 86 LAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
89-360 |
1.35e-17 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 83.50 E-value: 1.35e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 89 RPHQDDghevslkdgrLIKLDITALAPEPGQLILMTDLTETRRLQKR-VAHMQRLSALGKMVAS-------LAHQVRTPL 160
Cdd:PRK10604 158 RPHWQD----------MLKLEAAAQRLGDGHLAERIHFDEGSSLERLgVAFNQMADNINALIASkkqlidgIAHELRTPL 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 161 sAAMLYAANLgSKRLPEASRGSfhtkLMSRLKDLETQVNDMLLFAKSGDQQVVEQVSMQQLLSEVKTGADAMVALN-DSE 239
Cdd:PRK10604 228 -VRLRYRLEM-SDNLSAAESQA----LNRDIGQLEALIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTpEKT 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 240 LNVSLPEPDIEIMGNKTALASAIQNLIHNSIQVigSGAQVHLSALRDmqdPDYVRISVSDNGPGLDLAQTEKIFEPFY-- 317
Cdd:PRK10604 302 VRLDTPHQGDYGALDMRLMERVLDNLLNNALRY--AHSRVRVSLLLD---GNQACLIVEDDGPGIPPEERERVFEPFVrl 376
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1036092938 318 ----TTKSQGTGLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLLPI 360
Cdd:PRK10604 377 dpsrDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPV 423
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
258-359 |
4.51e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 76.29 E-value: 4.51e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 258 LASAIQNLIHNSIQVI-GSGAQVHLSALRDMQ----DPDY---VRISVSDNGPGL--DLAQTekIFEPFYTTKSQGTGLG 327
Cdd:cd16918 1 LIQVFLNLVRNAAQALaGSGGEIILRTRTQRQvtlgHPRHrlaLRVSVIDNGPGIppDLQDT--IFYPMVSGRENGTGLG 78
|
90 100 110
....*....|....*....|....*....|..
gi 1036092938 328 LAVVSSVASAHQGRVEADNNPqGGAIFSMLLP 359
Cdd:cd16918 79 LAIAQNIVSQHGGVIECDSQP-GHTVFSVSLP 109
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
45-359 |
2.57e-16 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 79.67 E-value: 2.57e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 45 DTMPAGVIVLDGKGMIAKANQIAIDMLGEplegeKW----------------FS--VIQRSF-RPHqddghEVSLKDGRL 105
Cdd:PRK11006 105 ESLPDAVVLTTEEGNIFWCNGLAQQLLGF-----RWpedngqnilnllrypeFTqyLKTRDFsRPL-----TLVLNNGRH 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 106 IKLDITALAPepGQLILMT-DLTETRRLQKrvahMQRlsalgKMVASLAHQVRTPLSAAMLYAANLGSKRLPEASRGSFH 184
Cdd:PRK11006 175 LEIRVMPYTE--GQLLMVArDVTQMHQLEG----ARR-----NFFANVSHELRTPLTVLQGYLEMMQDQPLEGALREKAL 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 185 TKLMSRLKDLETQVNDMLLFAK---SGDQQVVEQVSMQQLLSEVKTGAdamVALNDSELNVSLP-EPDIEIMGNKTALAS 260
Cdd:PRK11006 244 HTMREQTQRMEGLVKQLLTLSKieaAPTIDLNEKVDVPMMLRVLEREA---QTLSQGKHTITFEvDNSLKVFGNEDQLRS 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 261 AIQNLIHNSIQVIGSGAQVHLSALRDMQDPdyvRISVSDNGPGLDLAQTEKIFEPFY------TTKSQGTGLGLAVVSSV 334
Cdd:PRK11006 321 AISNLVYNAVNHTPEGTHITVRWQRVPQGA---EFSVEDNGPGIAPEHIPRLTERFYrvdkarSRQTGGSGLGLAIVKHA 397
|
330 340
....*....|....*....|....*
gi 1036092938 335 ASAHQGRVEADNNPQGGAIFSMLLP 359
Cdd:PRK11006 398 LSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
150-360 |
3.70e-16 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 79.29 E-value: 3.70e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 150 ASLAHQVRTPLSA--AMLYAANLGSKRLPEASRGSFH------TKLMSRLKDLETQVNDMLLFAKSgdqqvveQVSMQQL 221
Cdd:PRK10549 245 ADISHELRTPLAVlrGELEAIQDGVRKFTPESVASLQaevgtlTKLVDDLHQLSLSDEGALAYRKT-------PVDLVPL 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 222 LsEVKTGA-DAMVALNDSELNVSLPEpDIEIMGNKTALASAIQNLIHNSIQVIGSGAQVHLSALrdmQDPDYVRISVSDN 300
Cdd:PRK10549 318 L-EVAGGAfRERFASRGLTLQLSLPD-SATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAE---QRDKTLRLTFADS 392
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1036092938 301 GPGLDLAQTEKIFEPFYTTK------SQGTGLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLLPI 360
Cdd:PRK10549 393 APGVSDEQLQKLFERFYRTEgsrnraSGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPL 458
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
264-358 |
6.78e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 72.49 E-value: 6.78e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 264 NLIHNSIQVIGSGAQVHLSALRDMQDPDYVrISVSDNGPGLDLAQTEKIFEPFYTTK--SQGTGLGLAVVSSVASAHQGR 341
Cdd:cd16976 7 NLLQNALDAMGKVENPRIRIAARRLGGRLV-LVVRDNGPGIAEEHLSRVFDPFFTTKpvGKGTGLGLSISYGIVEEHGGR 85
|
90
....*....|....*..
gi 1036092938 342 VEADNNPQGGAIFSMLL 358
Cdd:cd16976 86 LSVANEEGAGARFTFDL 102
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
122-341 |
8.02e-16 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 78.96 E-value: 8.02e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 122 LMTDLTETRRLQKRVAHMQ-------RLSALGKMVASLAHQVRTPLSA--AMLYAANLGSKRLPEASRGSFHTKLMSRLK 192
Cdd:COG4192 403 LETEIEERKRIEKNLRQTQdeliqaaKMAVVGQTMTSLAHELNQPLNAmsMYLFSAKKALEQENYAQLPTSLDKIEGLIE 482
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 193 DLETQVNDMLLFAKSGDQQVVEqVSMQQLLsevkTGADAMVALNDSELNVSLPEP-DIEIMGNKTALASAIQNLIHNSIQ 271
Cdd:COG4192 483 RMDKIIKSLRQFSRKSDTPLQP-VDLRQVI----EQAWELVESRAKPQQITLHIPdDLMVQGDQVLLEQVLVNLLVNALD 557
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 272 VIGSGAQVHLSALRDmqdPDYVRISVSDNGPGLDLAqtEKIFEPFYTTKSQGTGLGLAVVSSVASAHQGR 341
Cdd:COG4192 558 AVATQPQISVDLLSN---AENLRVAISDNGNGWPLV--DKLFTPFTTTKEVGLGLGLSICRSIMQQFGGD 622
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
262-359 |
8.99e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 72.53 E-value: 8.99e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 262 IQNLIHNSI------QVIgsgaqVHLSALRDMQDPDYVRISVSDNGPGLDLAQTEKIFEPF------YTTKSQGTGLGLA 329
Cdd:cd16922 5 LLNLLGNAIkfteegEVT-----LRVSLEEEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFsqadssTTRKYGGTGLGLA 79
|
90 100 110
....*....|....*....|....*....|
gi 1036092938 330 VVSSVASAHQGRVEADNNPQGGAIFSMLLP 359
Cdd:cd16922 80 ISKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
258-359 |
9.15e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 72.32 E-value: 9.15e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 258 LASAIQNLIHNSIQVIGS----GAQVHLSaLRDMQDpdYVRISVSDNGPGLDLAQTEKIFEPFYTTKSQGT-GLGLAVVS 332
Cdd:cd16915 1 LITIVGNLIDNALDALAAtgapNKQVEVF-LRDEGD--DLVIEVRDTGPGIAPELRDKVFERGVSTKGQGErGIGLALVR 77
|
90 100
....*....|....*....|....*..
gi 1036092938 333 SVASAHQGRVEADNNPQGGAIFSMLLP 359
Cdd:cd16915 78 QSVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
258-359 |
5.31e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 70.05 E-value: 5.31e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 258 LASAIQNLIHNSIQVIGSG--AQVHLSAlrdMQDPDYVRISVSDNGPGLDLAQTEKIFEPFYTTKSQ----GTGLGLAVV 331
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpPRIEVGA---EDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSReeyeGTGVGLAIV 77
|
90 100
....*....|....*....|....*...
gi 1036092938 332 SSVASAHQGRVEADNNPQGGAIFSMLLP 359
Cdd:cd16921 78 RKIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
258-359 |
6.04e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 69.79 E-value: 6.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 258 LASAIQNLIHNSIQVIGSGAQVHLSAlrdmqDPDYVRISVSDNGPGLDLAQTEKIFEPFY----TTKSQGTGLGLAVVSS 333
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGWVEVSSDG-----EGNRTRIQVLDNGPGIAPEEVDELFQPFYrgdnARGTSGTGLGLAIVQR 75
|
90 100
....*....|....*....|....*.
gi 1036092938 334 VASAHQGRVEADNNPQGGAIFSMLLP 359
Cdd:cd16950 76 ISDAHGGSLTLANRAGGGLCARIELP 101
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
41-360 |
8.04e-15 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 74.73 E-value: 8.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 41 SHLVDTMPAGVIVLDGKGMIAKAN--------QIAIDMLGEPL-EGEKWFSVIQRSFRPHQDDGH-----EVSLK-DGRL 105
Cdd:PRK11073 10 GQILNSLINSILLLDDDLAIHYANpaaqqllaQSSRKLFGTPLpELLSYFSLNIELMRESLQAGQgftdnEVTLViDGRS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 106 IKLDITAlAPEPGQLIL--MTDLTETRRL-QKRVAHMQRLSAlGKMVASLAHQVRTPLsAAMLYAANLGSKRLPEASRGS 182
Cdd:PRK11073 90 HILSLTA-QRLPEGMILleMAPMDNQRRLsQEQLQHAQQVAA-RDLVRGLAHEIKNPL-GGLRGAAQLLSKALPDPALTE 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 183 FhTKLM----SRLKDLEtqvnDMLLfaksGDQQVVEQV--SMQQLLSEVKtgadAMVALNDSElNV--------SLPEPD 248
Cdd:PRK11073 167 Y-TKVIieqaDRLRNLV----DRLL----GPQRPGTHVteSIHKVAERVV----QLVSLELPD-NVrlirdydpSLPELA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 249 IEimgnKTALASAIQNLIHNSIQVIG-SGAQVHLSALRDMQDPDY-------VRISVSDNGPGLDLAQTEKIFEPFYTTK 320
Cdd:PRK11073 233 HD----PDQIEQVLLNIVRNALQALGpEGGTITLRTRTAFQLTLHgeryrlaARIDIEDNGPGIPPHLQDTLFYPMVSGR 308
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1036092938 321 SQGTGLGLAVVSSVASAHQGRVEADNNPqGGAIFSMLLPI 360
Cdd:PRK11073 309 EGGTGLGLSIARNLIDQHSGKIEFTSWP-GHTEFSVYLPI 347
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
262-359 |
8.58e-15 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 69.83 E-value: 8.58e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 262 IQNLIHNSIQVIGSGAQVHLSAlrDMQDPDYVRISVSDNGPGLDLAQTEKIFEPFY------TTKSQGTGLGLAVVSSVA 335
Cdd:cd16925 9 VLNLLSNAFKFTPDGGRIRCIL--EKFRLNRFLLTVSDSGPGIPPNLREEIFERFRqgdgssTRAHGGTGLGLSIVKEFV 86
|
90 100
....*....|....*....|....
gi 1036092938 336 SAHQGRVEADNNPQGGAIFSMLLP 359
Cdd:cd16925 87 ELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
254-359 |
1.16e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 69.49 E-value: 1.16e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 254 NKTALASAIQNLIHNSIQVIGSGAQVHLSALRDMQDPDYVRIS--VSDNGPGLDLAQTEKIFEPFYTTKSQGTGLGLAVV 331
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIEGRPSDVGEVRIRVEADQDGRIVliVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIV 80
|
90 100
....*....|....*....|....*...
gi 1036092938 332 SSVASAHQGRVEADNNPQGGAIFSMLLP 359
Cdd:cd16944 81 KKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
118-360 |
1.32e-14 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 74.22 E-value: 1.32e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 118 GQLILMTDltETRRL-QKRVAHMQRLSALGKMVASLAHQVRTPLSAAML------YAANLGSKRLPEASRGSFHTKLMSR 190
Cdd:PRK09303 125 QELLQLSD--ELFVLrQENETLLEQLKFKDRVLAMLAHDLRTPLTAASLaletleLGQIDEDTELKPALIEQLQDQARRQ 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 191 LKDLETQVNDMLLFAKSGDQQVV---EQVSMQQLLSEVKTGADAMVALNDSELNVSLPePDI-EIMGNKTALASAIQNLI 266
Cdd:PRK09303 203 LEEIERLITDLLEVGRTRWEALRfnpQKLDLGSLCQEVILELEKRWLAKSLEIQTDIP-SDLpSVYADQERIRQVLLNLL 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 267 HNSIQVIGSGAQVHLSAL-RDMQdpdYVRISVSDNGPGLDLAQTEKIFEP-FYTTKSQGT---GLGLAVVSSVASAHQGR 341
Cdd:PRK09303 282 DNAIKYTPEGGTITLSMLhRTTQ---KVQVSICDTGPGIPEEEQERIFEDrVRLPRDEGTegyGIGLSVCRRIVRVHYGQ 358
|
250
....*....|....*....
gi 1036092938 342 VEADNNPQGGAIFSMLLPI 360
Cdd:PRK09303 359 IWVDSEPGQGSCFHFTLPV 377
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
258-359 |
3.05e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 68.38 E-value: 3.05e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 258 LASAIQNLIHNSIQVIGSGAQVhlsALRDMQDPDYVRISVSDNGPGLDLAQTEKIFEPFYTTKSQ------GTGLGLAVV 331
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTI---TVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIErcrntgGTGLGLAIV 77
|
90 100
....*....|....*....|....*...
gi 1036092938 332 SSVASAHQGRVEADNNPQGGAIFSMLLP 359
Cdd:cd16952 78 KHVMSRHDARLLIASELGKGSRFTCLFP 105
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
153-351 |
3.23e-14 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 73.53 E-value: 3.23e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 153 AHQVRTPLSAAMLYA--ANLGSKrlPEASRgsfhTKLMSRLK---DLETQVNDMLLFAK---SGDQ-QVVEQVSMQQLLS 223
Cdd:PRK10337 245 AHELRSPLAALKVQTevAQLSDD--DPQAR----KKALLQLHagiDRATRLVDQLLTLSrldSLDNlQDVAEIPLEDLLQ 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 224 EVKTGADAMVALNDSELNVSLPEPDIEIMGNKTALASAIQNLIHNSIQVIGSGAQVHLSALRDmqdpdyvRISVSDNGPG 303
Cdd:PRK10337 319 SAVMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNAR-------NFTVRDNGPG 391
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1036092938 304 LDLAQTEKIFEPFYTTKSQ---GTGLGLAVVSSVASAHQGRVEADNNPQGG 351
Cdd:PRK10337 392 VTPEALARIGERFYRPPGQeatGSGLGLSIVRRIAKLHGMNVSFGNAPEGG 442
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
150-359 |
6.27e-14 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 71.92 E-value: 6.27e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 150 ASLAHQVRTPLSAAMLyaaNLgskRLPEASRGSFHTKLMSRLKDLETQVNDMLLFAK------SGDQQVVEQVS-----M 218
Cdd:PRK10755 142 ADVAHELRTPLAGIRL---HL---ELLEKQHHIDVAPLIARLDQMMHTVEQLLQLARagqsfsSGHYQTVKLLEdvilpS 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 219 QQLLSEvktgadaMVALNDSELNVSLPEPDIEIMGNKTALASAIQNLIHNSIQVIGSGAQVHLSAlrdMQDPDYVRISVS 298
Cdd:PRK10755 216 QDELSE-------MLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKL---SQEDGGAVLAVE 285
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1036092938 299 DNGPGLDLAQTEKIFEPFYTTKSQ--GTGLGLAVVSSVASAHQGRVEADNNPQ-GGAIFSMLLP 359
Cdd:PRK10755 286 DEGPGIDESKCGELSKAFVRMDSRygGIGLGLSIVSRITQLHHGQFFLQNRQErSGTRAWVWLP 349
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
258-351 |
5.21e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 64.79 E-value: 5.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 258 LASAIQNLIHNSIQVIGSGAQVHLSAlrdMQDPDYVRISVSDNGPGLDLAQTEKIFEPFYT-----TKSQGTGLGLAVVS 332
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQL---EADTEGIELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGLAFVQ 81
|
90
....*....|....*....
gi 1036092938 333 SVASAHQGRVEADNNPQGG 351
Cdd:cd16945 82 EVAQLHGGRITLRNRPDGV 100
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
258-359 |
9.21e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 64.32 E-value: 9.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 258 LASAIQNLIHNSIQVIGSGAQVHLSALRDMQDPD------------YVRISVSDNGPGLDLAQTEKIFEPFYTTK--SQG 323
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLTIETSNQRVDADyalnyrdlipgnYVCLEVSDTGSGMPAEVLRRAFEPFFTTKevGKG 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 1036092938 324 TGLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLLP 359
Cdd:cd16919 81 TGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
239-358 |
1.40e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 64.19 E-value: 1.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 239 ELNVSLPePDIEIMGNKTALASAIQNLIHNSIQVigSGAQVHLSAlrdMQDPDYVRISVSDNGPGLDLAQTEKIFE--PF 316
Cdd:cd16954 20 SISLDIS-PELRFPGERNDLMELLGNLLDNACKW--CLEFVEVTA---RQTDGGLHLIVDDDGPGVPESQRSKIFQrgQR 93
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1036092938 317 YTTKSQGTGLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLL 358
Cdd:cd16954 94 LDEQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
258-359 |
2.24e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 62.98 E-value: 2.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 258 LASAIQNLIHNSIQVIGSGaQVHLSaLRDMQDPDYVRISVSDNGPGLDLAQTEKIFEPFYTTK------SQGTGLGLAVV 331
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPD-TGRIT-VSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERpaneafGQHSGLGLSIS 78
|
90 100 110
....*....|....*....|....*....|..
gi 1036092938 332 SSVASAHQGRVEADN-NPQG---GAIFSMLLP 359
Cdd:cd16953 79 RQIIEAHGGISVAENhNQPGqviGARFTVQLP 110
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
239-358 |
2.95e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 63.30 E-value: 2.95e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 239 ELNVSLPEPDIEIMGNKTALASAIQNLIHNSIQVIGSGAQVHLSaLRDmqDPDYVRISVSDNGPGLDLAQTEKIFEPFYT 318
Cdd:cd16947 2 QVEINIPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMT-LRE--DEKHVYIDIWDKGKGISETEKDHVFERLYT 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1036092938 319 TKS------QGTGLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLL 358
Cdd:cd16947 79 LEDsrnsakQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
125-367 |
5.22e-12 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 67.45 E-value: 5.22e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 125 DLTETRRL-----QKRVAHMQRLSALGKMVASLAHQVRTPLSAAMLYAANLGSKRLPEASRGSFHTKLMSRLKDLETQVN 199
Cdd:PRK09959 687 DITETRDLihaleVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIG 766
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 200 DMLLFAK--SGDQQVVEQ-VSMQQLLSEVKTGADAMVALNDSELNVSLPEPDIEIMG-NKTALASAIQNLIHNSIQVIGS 275
Cdd:PRK09959 767 EILDVDKieSGNYQLQPQwVDIPTLVQNTCHSFGAIAASKSIALSCSSTFPDHYLVKiDPQAFKQVLSNLLSNALKFTTE 846
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 276 GAQVHLSALRDMQDPDYV-RISVSDNGPGLDLAQTEKIFEPFYTT----KSQGTGLGLAVVSSVASAHQGRVEADNNPQG 350
Cdd:PRK09959 847 GAVKITTSLGHIDDNHAViKMTIMDSGSGLSQEEQQQLFKRYSQTsagrQQTGSGLGLMICKELIKNMQGDLSLESHPGI 926
|
250
....*....|....*..
gi 1036092938 351 GAIFSMLLPISVTSKLG 367
Cdd:PRK09959 927 GTTFTITIPVEISQQVA 943
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
149-360 |
1.73e-11 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 65.70 E-value: 1.73e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 149 VASLAHQVRTPLSAAMLYAANLGSKRLPEASRGSFHTkLMSRLKDLETQVNDMLLFA--KSGDQQVV---EQVSMQQLLS 223
Cdd:PRK11466 448 LAAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLRA-ITDSGESLLTILNDILDYSaiEAGGKNVSvsdEPFEPRPLLE 526
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 224 EVKTGADAMVALN----DSELNVSLPEpdiEIMGNKTALASAIQNLIHNSIQVIGSGAQVhlsaLRDMQDPDYVRISVSD 299
Cdd:PRK11466 527 STLQLMSGRVKGRpirlATDIADDLPT---ALMGDPRRIRQVITNLLSNALRFTDEGSIV----LRSRTDGEQWLVEVED 599
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1036092938 300 NGPGLDLAQTEKIFEPFY--TTKSQGTGLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLLPI 360
Cdd:PRK11466 600 SGCGIDPAKLAEIFQPFVqvSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPL 662
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
150-359 |
2.65e-10 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 61.71 E-value: 2.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 150 ASLAHQVRTPLS-----AAMLYAANLGSKRLPEAsrgsfhtkLMSRLKDLE---TQVNDMLLFAKSGDQQVVEQVSMQQL 221
Cdd:PRK09835 267 ADIAHEIRTPITnlitqTEIALSQSRSQKELEDV--------LYSNLEELTrmaKMVSDMLFLAQADNNQLIPEKKMLDL 338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 222 LSEVKTGADAMVALNDsELNVSLPEPDIE--IMGNKTALASAIQNLIHNSIQVIGSGAQVHLSaLRDMQDpdYVRISVSD 299
Cdd:PRK09835 339 ADEVGKVFDFFEAWAE-ERGVELRFVGDPcqVAGDPLMLRRAISNLLSNALRYTPAGEAITVR-CQEVDH--QVQLVVEN 414
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1036092938 300 NGPGLDLAQTEKIFEPFYTT------KSQGTGLGLAVVSSVASAHQGRVEADNNPQGGAiFSMLLP 359
Cdd:PRK09835 415 PGTPIAPEHLPRLFDRFYRVdpsrqrKGEGSGIGLAIVKSIVVAHKGTVAVTSDARGTR-FVISLP 479
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
295-361 |
2.65e-10 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 61.97 E-value: 2.65e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1036092938 295 ISVSDNGPGLDLAQTEKIFEPFYTT--KSQGTGLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLLPIS 361
Cdd:PRK15347 547 FTVEDTGCGIDIQQQQQIFTPFYQAdtHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPLN 615
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
246-360 |
1.96e-09 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 59.22 E-value: 1.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 246 EPDI--EIMGNKTALASAIQNLIHNSIQVIGSGAQV-HLSAlrdmqDPDYVRISVSDNGPGLDLAQTEKIFEPFYT---- 318
Cdd:PRK10841 549 EPDVpvALNGDPMRLQQVISNLLSNAIKFTDTGCIVlHVRV-----DGDYLSFRVRDTGVGIPAKEVVRLFDPFFQvgtg 623
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1036092938 319 --TKSQGTGLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLLPI 360
Cdd:PRK10841 624 vqRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIPL 667
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
254-352 |
2.53e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 51.31 E-value: 2.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 254 NKTALASAIQNLIHNSIQVIGSGAQVHLSAlrdMQDPDYVRISVSDNGPGLDLAQTEKIFEPFYTTKSQGT-----GLGL 328
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISI---YDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRsgghyGMGL 77
|
90 100
....*....|....*....|....
gi 1036092938 329 AVVSSVASAHQGRVEADNNPQGGA 352
Cdd:cd16975 78 YIAKNLVEKHGGSLIIENSQKGGA 101
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
144-206 |
4.32e-08 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 49.52 E-value: 4.32e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1036092938 144 ALGKMVASLAHQVRTPLSAAMLYAANLGSKRLPEASRGSFHTkLMSRLKDLETQVNDMLLFAK 206
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLET-ILRSAERLLRLINDLLDLSR 62
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
144-206 |
9.29e-08 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 48.72 E-value: 9.29e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1036092938 144 ALGKMVASLAHQVRTPLSAAMLYAANLGSKRLPEASRGSFHTkLMSRLKDLETQVNDMLLFAK 206
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLET-ILREAERLLRLINDLLDLSR 62
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
142-206 |
1.01e-07 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 48.36 E-value: 1.01e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1036092938 142 LSALGKMVASLAHQVRTPLSAAMLYAANLGSKRLPEASRGSFHTKLMSRLKDLETQVNDMLLFAK 206
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
292-361 |
1.06e-07 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 53.52 E-value: 1.06e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1036092938 292 YVRISVSDNGPGLDLAQTEKIFEPFYTTKS--QGTGLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLLPIS 361
Cdd:PRK13557 324 YVSIAVTDTGSGMPPEILARVMDPFFTTKEegKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPAS 395
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
258-359 |
2.79e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 48.15 E-value: 2.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 258 LASAIQNLIHNSIQVIGSGAQVHLSALrdmQDPDYVRISVSDNGPGLDLAQTEKIFEPFY----TTKSQGTGLGLAVVSS 333
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSF---LTDDVVNIMFKNPSSHPLDFKLEKLFERFYrgdnSRNTEGAGLGLSIAKA 77
|
90 100
....*....|....*....|....*...
gi 1036092938 334 VASAHQGRVEA--DNNpqgGAIFSMLLP 359
Cdd:cd16923 78 IIELHGGSASAeyDDN---HDLFKVRLP 102
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
256-359 |
6.12e-07 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 51.07 E-value: 6.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 256 TALASAIQNLIHNSIQVIGSGAQVHLSALRDMQDpDYVRISVSDNGPGLDLAQTEKIFEPFYTTKSQGTGLGLAVVSSVA 335
Cdd:PRK11086 432 HELITILGNLIENALEAVGGEEGGEISVSLHYRN-GWLHCEVSDDGPGIAPDEIDAIFDKGYSTKGSNRGVGLYLVKQSV 510
|
90 100
....*....|....*....|....
gi 1036092938 336 SAHQGRVEADNNPQGGAIFSMLLP 359
Cdd:PRK11086 511 ENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
216-370 |
2.16e-06 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 49.55 E-value: 2.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 216 VSMQQLLSEVKTGADAMVALNDSELNVSLPEP-DIEIMGNKTALASAIQNLIHNSIQVIGSGaQVHLSALRDmqDPDYVR 294
Cdd:PRK11091 356 IDFTDFLADLENLSGLQAEQKGLRFDLEPLLPlPHKVITDGTRLRQILWNLISNAVKFTQQG-GVTVRVRYE--EGDMLT 432
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 295 ISVSDNGPGLDLAQTEKIFEPFYTTKSQ-------GTGLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLLPISVTSKLG 367
Cdd:PRK11091 433 FEVEDSGIGIPEDELDKIFAMYYQVKDShggkpatGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHAPAVAEEV 512
|
...
gi 1036092938 368 ESQ 370
Cdd:PRK11091 513 EDA 515
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
40-98 |
2.19e-06 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 44.85 E-value: 2.19e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1036092938 40 LSHLVDTMPAGVIVLDGKGMIAKANQIAIDMLGEPLEGEKWFSVIQRSFRPHQDDGHEV 98
Cdd:pfam13188 3 LRALFESSPDGILVLDEGGRIIYVNPAALELLGYELLGELLGELLDLLDPLLEDALELL 61
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
151-360 |
1.65e-05 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 45.76 E-value: 1.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 151 SLAHQvrtpLSAAMLYAANLGSK--RLPEASRGSFhTKLMSRLKDLETQVNDML--LFAKSGDQQVVEQvSMQQLLSEVK 226
Cdd:COG4585 64 GVGQS----LSAIKLQLEAARRLldADPEAAREEL-EEIRELAREALAELRRLVrgLRPPALDDLGLAA-ALEELAERLL 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 227 TGADAMVALNDSELNVSLPePDIEImgnktALASAIQNLIHNsiqVI----GSGAQVHLSalrdmQDPDYVRISVSDNGP 302
Cdd:COG4585 138 RAAGIRVELDVDGDPDRLP-PEVEL-----ALYRIVQEALTN---ALkhagATRVTVTLE-----VDDGELTLTVRDDGV 203
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1036092938 303 GLDLAQTEkifepfyttksqGTGLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLLPI 360
Cdd:COG4585 204 GFDPEAAP------------GGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPL 249
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
32-147 |
1.85e-05 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 46.30 E-value: 1.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 32 DLRQQASWLSHLVDTMPAGVIVLDGKGMIAKANQIAIDMLG---EPLEGEKWFSVIQRS-----FRPHQDDGHEVSLKDG 103
Cdd:COG3829 5 ELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGlprEEVIGKNVTELIPNSpllevLKTGKPVTGVIQKTGG 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1036092938 104 RLIKLDITAlAP--EPGQLI----LMTDLTETRRLQKRVAHMQRLSALGK 147
Cdd:COG3829 85 KGKTVIVTA-IPifEDGEVIgaveTFRDITELKRLERKLREEELERGLSA 133
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
262-360 |
1.90e-05 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 46.16 E-value: 1.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 262 IQNLIHNSI----QVIGSGAQVHLSAlrdMQDPDYVRISVSDNGPGLDLAQTEKIFEPFyTTKSQGTGLGLAVVSSVASA 337
Cdd:COG2972 341 LQPLVENAIehgiEPKEGGGTIRISI---RKEGDRLVITVEDNGVGMPEEKLEKLLEEL-SSKGEGRGIGLRNVRERLKL 416
|
90 100
....*....|....*....|....*.
gi 1036092938 338 HQG---RVEADNNPQGGAIFSMLLPI 360
Cdd:COG2972 417 YYGeeyGLEIESEPGEGTTVTIRIPL 442
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
38-91 |
5.51e-05 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 40.85 E-value: 5.51e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 1036092938 38 SWLSHLVDTMPAGVIVLDGKGMIAKANQIAIDMLG---EPLEGEKWFSVIQRSFRPH 91
Cdd:smart00091 1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGyspEELIGKSLLELIHPEDRER 57
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
33-135 |
8.00e-05 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 43.86 E-value: 8.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 33 LRQQASWLSHLVDTMPAGVIVLDGKGMIAKANQIAIDMLGEPLE---------------GEKWFSVIQRSFRPHQDDGH- 96
Cdd:COG2202 132 LRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEellgkslldllhpedRERLLELLRRLLEGGRESYEl 211
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1036092938 97 EVSLKDGRLIKLDITALAPE-------PGQLILMTDLTETRRLQKR 135
Cdd:COG2202 212 ELRLKDGDGRWVWVEASAVPlrdggevIGVLGIVRDITERKRAEEA 257
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
214-361 |
8.67e-05 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 44.51 E-value: 8.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 214 EQVSMQQLLSEVKTGADAMVALNDSELNVSLPepDIEIMGNK-TALASAIQNLIHNSIQ---VIGSGAQVHLSALRDmqd 289
Cdd:COG3920 357 EGVDLRDYLRELLEPLRDSYGGRGIRIELDGP--DVELPADAaVPLGLILNELVTNALKhafLSGEGGRIRVSWRRE--- 431
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1036092938 290 PDYVRISVSDNGPGLdlaqtekifePFYTTKSQGTGLGLAVVSSVASAHQGRVEADNNPqgGAIFSMLLPIS 361
Cdd:COG3920 432 DGRLRLTVSDNGVGL----------PEDVDPPARKGLGLRLIRALVRQLGGTLELDRPE--GTRVRITFPLA 491
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
258-347 |
8.83e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 41.50 E-value: 8.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 258 LASAIQNLIHNSIQVIGSGAQVhlsALRDMQDPDYVRISVSDNGPGLDLAQTEKIFEPFYTTK-----SQGTGLGLAVVS 332
Cdd:cd16948 6 LSFIIGQIVSNALKYSKQGGKI---EIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGEngrnfQESTGMGLYLVK 82
|
90
....*....|....*..
gi 1036092938 333 SVAS--AHQGRVEADNN 347
Cdd:cd16948 83 KLCDklGHKIDVESEVG 99
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
279-352 |
1.29e-04 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 43.85 E-value: 1.29e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1036092938 279 VHLSALrdmQDPDYVRISVSDNGPGLDLAQTEKIFE--PFYTTKSQGTGLGLAVVSSVASAHQGRVEADNNPQGGA 352
Cdd:PRK10815 398 VEISAR---QTDEHLHIVVEDDGPGIPESKRELIFDrgQRADTLRPGQGLGLSVAREITEQYEGKISAGDSPLGGA 470
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
278-362 |
4.40e-04 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 42.09 E-value: 4.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 278 QVHLSALrdmQDPDYVRISVSDNGPGLDLAQ-------------------TEK-----IFEPFYTTKSQ-----GTGLGL 328
Cdd:COG0643 310 TITLSAY---HEGGRVVIEVSDDGRGLDLEKirakaiekglitaeeaaalSDEellelIFAPGFSTAEEvtdlsGRGVGM 386
|
90 100 110
....*....|....*....|....*....|....
gi 1036092938 329 AVVSSVASAHQGRVEADNNPQGGAIFSMLLPISV 362
Cdd:COG0643 387 DVVKTNIEALGGTIEIESEPGKGTTFTLRLPLTL 420
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
254-359 |
8.28e-04 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 41.36 E-value: 8.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 254 NKTALASAIQNLIHNSIQVI------GSGAQVHLSalrdmQDPDYVRISVSDNGPGLDLAQTEKIFEPFYTTKSQGT--- 324
Cdd:PRK15053 429 DSTEFAAIVGNLLDNAFEASlrsdegNKIVELFLS-----DEGDDVVIEVADQGCGVPESLRDKIFEQGVSTRADEPgeh 503
|
90 100 110
....*....|....*....|....*....|....*
gi 1036092938 325 GLGLAVVSSVASAHQGRVEADNNPQGGAIFSMLLP 359
Cdd:PRK15053 504 GIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIP 538
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
29-145 |
1.13e-03 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 40.39 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 29 ELSDLRQQASWLSHLVDTMPAGVIVLDGKGMIAKANQIAIDMLG---EPLEGEKWFSVIQRSFRPHQDDGHEVSL----- 100
Cdd:COG2202 2 AEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGysaEELLGKTLRDLLPPEDDDEFLELLRAALagggv 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1036092938 101 ---------KDGRLIKLDITALAP--EPGQLI----LMTDLTETRRLQKRVAHM-QRLSAL 145
Cdd:COG2202 82 wrgelrnrrKDGSLFWVELSISPVrdEDGEITgfvgIARDITERKRAEEALRESeERLRLL 142
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
284-359 |
3.40e-03 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 37.95 E-value: 3.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036092938 284 LRDMQDPDYVRISVSDNGPGLDLAQ-------------------TEK-----IFEPFYTTKSQ-----GTGLGLAVVSSV 334
Cdd:cd16916 74 LRAEHQGNQVVIEVSDDGRGIDREKirekaierglitadeaatlSDDevlnlIFAPGFSTAEQvtdvsGRGVGMDVVKRS 153
|
90 100
....*....|....*....|....*
gi 1036092938 335 ASAHQGRVEADNNPQGGAIFSMLLP 359
Cdd:cd16916 154 IESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
289-350 |
5.71e-03 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 36.43 E-value: 5.71e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1036092938 289 DPDYVRISVSDNGPGLDLAQTEKIFEPfyttkSQGTGLGLAVVSSVASahqgRVEADNNPQG 350
Cdd:COG2172 66 DPDGLEIEVRDEGPGFDPEDLPDPYST-----LAEGGRGLFLIRRLMD----EVEYESDPGG 118
|
|
| |
