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Conserved domains on  [gi|1036810247|ref|WP_064728056|]
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MULTISPECIES: ectoine/hydroxyectoine ABC transporter permease subunit EhuD [Streptomyces]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-214 9.49e-79

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 234.97  E-value: 9.49e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247   1 MNWDWSAVSDFMPHFWDGLLVTLQILVLGSAVSFALGLVWALLMRVPSRWVTWPIGVVTEFVRNTPLLVQLFFLFYVLPE 80
Cdd:COG0765     1 MFFDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  81 WNITFSALTTGVVAIGLHYSTYTMQVYRAGIEAVPVGQWEAATALNLPLRRTWTAVILPQAIRRVVPALGNYVISMLKDT 160
Cdd:COG0765    81 LGIDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1036810247 161 PLLMAITVLEMLGEARLFSQQNFQFTEPLTVIGVAFIIISYLASLALRALERRL 214
Cdd:COG0765   161 SLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRL 214
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-214 9.49e-79

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 234.97  E-value: 9.49e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247   1 MNWDWSAVSDFMPHFWDGLLVTLQILVLGSAVSFALGLVWALLMRVPSRWVTWPIGVVTEFVRNTPLLVQLFFLFYVLPE 80
Cdd:COG0765     1 MFFDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  81 WNITFSALTTGVVAIGLHYSTYTMQVYRAGIEAVPVGQWEAATALNLPLRRTWTAVILPQAIRRVVPALGNYVISMLKDT 160
Cdd:COG0765    81 LGIDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1036810247 161 PLLMAITVLEMLGEARLFSQQNFQFTEPLTVIGVAFIIISYLASLALRALERRL 214
Cdd:COG0765   161 SLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRL 214
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 3-214 2.52e-77

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 231.28  E-value: 2.52e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247   3 WDWSAVSDFMPHFWDGLLVTLQILVLGSAVSFALGLVWALLMRVPSRWVTWPIGVVTEFVRNTPLLVQLFFLFYVLPEWN 82
Cdd:TIGR03003   1 WDWEFVRQILPTLIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDIG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  83 ITFSALTTGVVAIGLHYSTYTMQVYRAGIEAVPVGQWEAATALNLPLRRTWTAVILPQAIRRVVPALGNYVISMLKDTPL 162
Cdd:TIGR03003  81 IRLPALVAGVLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPV 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1036810247 163 LMAITVLEMLGEARLFSQQNFQFTEPLTVIGVAFIIISYLASLALRALERRL 214
Cdd:TIGR03003 161 LSAITVLELMNQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEARL 212
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 1-214 2.33e-34

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 121.70  E-value: 2.33e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247   1 MNWDWSAVSDFMPHFWDGLLVTLQILVLGSAVSFALGLVwALLMRVPSRWVTWPIGVV-TEFVRNTPLLVQLFFLFYVLP 79
Cdd:PRK09494    1 MQFDWSAIWPAIPLLLEGAKMTLWISVLGLAGGLVIGLL-AGFARAYGGWIANHIALVfIELIRGTPIVVQVMFIYFALP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  80 E--WNITFSALTTGVVAIGLHYSTYTMQVYRAGIEAVPVGQWEAATALNLPLRRTWTAVILPQAIRRVVPALGNYVISML 157
Cdd:PRK09494   80 MafNDLRIDPFTAAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISI 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1036810247 158 KDTPLLMAITVLEMLGEARLFSQQNFQFTEPLTVIGVAFIIISYLASLALRALERRL 214
Cdd:PRK09494  160 KDTSLFIVIGVAELTRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRLERRM 216
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 19-205 2.84e-16

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 73.47  E-value: 2.84e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  19 LLVTLQILVLGSAVSFALGLVWALLMRVPSRWVTWPIGVVTEFVRNTPLLVQLFFLFYVLP---EWNITFSALTTGVVAI 95
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGvllGWGILPGLGLPALILA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  96 GLHYSTYTMQVYRAGIEAVPVGQWEAATALNLPLRRTWTAVILPQAIRRVVPALGNYVISMLKDTPLLMAITVLEMLGEA 175
Cdd:cd06261    81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                         170       180       190
                  ....*....|....*....|....*....|
gi 1036810247 176 RLFSQQNFQFTEPLTVIGVAFIIISYLASL 205
Cdd:cd06261   161 TGLLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 37-214 1.07e-11

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 61.16  E-value: 1.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  37 GLVWALLM-RVPSRWVTWPIGVVTEFVRNTPLLVQLFFLFYVlPEWNITFSALTTGVVAIGLHYSTYTMQVYRAGIEAVP 115
Cdd:pfam00528   1 GIPLGIIAaLRRGRRLDRLLRPLIDLLQALPSFVLAILLVVI-AILSILGHGILPAIILALLGWAGYARLIRRAALRSLP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247 116 VGQWEAATALNLPLRRTWTAVILPQAIRRVVPALGNYVISMLKDTPLLMAITVLEMLGEARLFSQQNFQFTE---PLTVI 192
Cdd:pfam00528  80 SDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEiqgPVLAA 159

                         170       180
                  ....*....|....*....|..
gi 1036810247 193 GVAFIIISYLASLALRALERRL 214
Cdd:pfam00528 160 ALILLLLNLLVDILQRLLDPRV 181
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-214 9.49e-79

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 234.97  E-value: 9.49e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247   1 MNWDWSAVSDFMPHFWDGLLVTLQILVLGSAVSFALGLVWALLMRVPSRWVTWPIGVVTEFVRNTPLLVQLFFLFYVLPE 80
Cdd:COG0765     1 MFFDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  81 WNITFSALTTGVVAIGLHYSTYTMQVYRAGIEAVPVGQWEAATALNLPLRRTWTAVILPQAIRRVVPALGNYVISMLKDT 160
Cdd:COG0765    81 LGIDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1036810247 161 PLLMAITVLEMLGEARLFSQQNFQFTEPLTVIGVAFIIISYLASLALRALERRL 214
Cdd:COG0765   161 SLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRL 214
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 3-214 2.52e-77

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 231.28  E-value: 2.52e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247   3 WDWSAVSDFMPHFWDGLLVTLQILVLGSAVSFALGLVWALLMRVPSRWVTWPIGVVTEFVRNTPLLVQLFFLFYVLPEWN 82
Cdd:TIGR03003   1 WDWEFVRQILPTLIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDIG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  83 ITFSALTTGVVAIGLHYSTYTMQVYRAGIEAVPVGQWEAATALNLPLRRTWTAVILPQAIRRVVPALGNYVISMLKDTPL 162
Cdd:TIGR03003  81 IRLPALVAGVLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPV 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1036810247 163 LMAITVLEMLGEARLFSQQNFQFTEPLTVIGVAFIIISYLASLALRALERRL 214
Cdd:TIGR03003 161 LSAITVLELMNQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEARL 212
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 3-214 1.28e-49

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 161.03  E-value: 1.28e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247   3 WDWSAVSDFMPHFWDGLLVTLQILVLGSAVSFALGLVWALLMRVPSRWVTWPIGVVTEFVRNTPLLVQLFFLFYVL---- 78
Cdd:COG4160     1 MDLDLLFEYLPLLLSGLPLTLQLLALSLLLGFLLAVPLALARASGNRLLRWPARGYIYVFRGTPLLVQLFLIYYGLgqfe 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  79 -----PEWNITFSALTTGVVAIGLHYSTYTMQVYRAGIEAVPVGQWEAATALNLPLRRTWTAVILPQAIRRVVPALGNYV 153
Cdd:COG4160    81 wvresWLWPLLRDPWFCALLALTLNTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQTFRRIILPSALRRALPAYSNEV 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1036810247 154 ISMLKDTPLLMAITVLEMLGEARLFSQQNFQFTEPLTVIGVAFIIISYLASLALRALERRL 214
Cdd:COG4160   161 ILMLKATALASTITVMDLTGVARRIYSRTYDPFEPFLIAALIYLVITFLLTRLFRLLERRL 221
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 1-214 2.33e-34

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 121.70  E-value: 2.33e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247   1 MNWDWSAVSDFMPHFWDGLLVTLQILVLGSAVSFALGLVwALLMRVPSRWVTWPIGVV-TEFVRNTPLLVQLFFLFYVLP 79
Cdd:PRK09494    1 MQFDWSAIWPAIPLLLEGAKMTLWISVLGLAGGLVIGLL-AGFARAYGGWIANHIALVfIELIRGTPIVVQVMFIYFALP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  80 E--WNITFSALTTGVVAIGLHYSTYTMQVYRAGIEAVPVGQWEAATALNLPLRRTWTAVILPQAIRRVVPALGNYVISML 157
Cdd:PRK09494   80 MafNDLRIDPFTAAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISI 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1036810247 158 KDTPLLMAITVLEMLGEARLFSQQNFQFTEPLTVIGVAFIIISYLASLALRALERRL 214
Cdd:PRK09494  160 KDTSLFIVIGVAELTRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRLERRM 216
PRK15100 PRK15100
cystine ABC transporter permease;
8-214 8.02e-33

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 117.93  E-value: 8.02e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247   8 VSDFMPHFWDGLLVTLQILVLGSAVSFALGLVWALLMRVPSRWVTWPIGVVTEFVRNTPLLVQLFFLFYVLPEWNITFSA 87
Cdd:PRK15100    8 VIDSAPFLLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQFGIELDP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  88 LTTGVVAIGLHYSTYTMQVYRAGIEAVPVGQWEAATALNLPLRRTWTAVILPQAIRRVVPALGNYVISMLKDTPLLMAIT 167
Cdd:PRK15100   88 IPAAMIGLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQ 167

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1036810247 168 VLEMLGEARLFSQQNFQ-FTEPLTVIGVAFIIISYLASLALRaLERRL 214
Cdd:PRK15100  168 VPELFRQAQLITSRTLEvFTMYLAASLIYWIMATVLSALQNR-FENQL 214
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 11-109 1.26e-29

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 105.69  E-value: 1.26e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  11 FMPHFWDGLLVTLQILVLGSAVSFALGLVWALLMRVPSRWVTWPIGVVTEFVRNTPLLVQLFFLFYVLPEWNITFSALTT 90
Cdd:TIGR01726   1 NLPFLLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPLIGIRLSPLTA 80

                          90
                  ....*....|....*....
gi 1036810247  91 GVVAIGLHYSTYTMQVYRA 109
Cdd:TIGR01726  81 AVIALTLFYGAYLAEIFRG 99
artM PRK11122
arginine ABC transporter permease ArtM;
10-213 1.26e-22

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 91.17  E-value: 1.26e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  10 DFMPHFWDGLLVTLQILVLGSAVSFALGLV--WALLMRVPsrWVTWPIGVVTEFVRNTPLLVQlFFLFYVLP---EWNIT 84
Cdd:PRK11122    3 EYLPELLKGLHTSLTLTVASLLVALVLALIftIILTLKTP--VLVWLVRGYITLFTGTPLLVQ-IFLIYYGPgqfPWLQE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  85 FSALTT--------GVVAIGLHYSTYTMQVYRAGIEAVPVGQWEAATALNLPLRRTwTAVILPQAIRRVVPALGNYVISM 156
Cdd:PRK11122   80 YPWLWHllsqpwlcAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQT-LRILLPYAFKRALSSYSNEVVLV 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1036810247 157 LKDTPLLMAITVLEMLGEARLFSQQNFQfTEPLTVIGVAFIIISYLASLALRALERR 213
Cdd:PRK11122  159 FKSTSLAYTITLMDVMGYSQLLYGRTYD-VMVFGAAGIIYLVVNGLLTLLMRLIERK 214
PRK15069 PRK15069
histidine ABC transporter permease HisM;
18-213 6.60e-22

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 89.72  E-value: 6.60e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  18 GLLVTLQILVLGSAVSFALGLVWALLMRVPSRWVTWPIGVVTEFVRNTPLLVQLFFLF---YVL------PEWNITF-SA 87
Cdd:PRK15069   22 GLAITLWLLVASVVIGFVLAVPLAIARVSSNKWIRFPVWLYTYVFRGTPLYVQLLVFYtgmYSLeivrgtDLLDAFFrSG 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  88 LTTGVVAIGLHYSTYTMQVYRAGIEAVPVGQWEAATALNLPLRRTWTAVILPQAIRRVVPALGNYVISMLKDTPLLMAIT 167
Cdd:PRK15069  102 LNCTILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLHATTLAFTAT 181

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1036810247 168 VLEMLGEARLFSQQNFQFTEPLTVIGVAFIIISYLASLALRALERR 213
Cdd:PRK15069  182 VPDILKIARDINSATYQPFQAFGIAAVLYLIISFVLISLFRRAERR 227
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
20-213 3.84e-21

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 87.81  E-value: 3.84e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  20 LVTLQILVLGSAVSFALGLVWALLMRVPSRWVTWPIGVVTEFVRNTP-LLVQLFFLF----------------------- 75
Cdd:PRK11123   12 GMTVGLAVCALIVGLALAMLFAVWESAKWRPVAWPGTALVTLLRGLPeILVVLFIYFgssqllltlsdgftlnlgfvqip 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  76 YVLPEWNITFSALTTGVVAIGLHYSTYTMQVYRAGIEAVPVGQWEAATALNLPLRRTWTAVILPQAIRRVVPALGNYVIS 155
Cdd:PRK11123   92 VQMDIENFEVSPFLCGVIALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLGNQWLV 171

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1036810247 156 MLKDTPLLMAITVLEMLGEARLFSQQNfqfTEPLTVIGVA---FIIISYLASLALRALERR 213
Cdd:PRK11123  172 LLKDTALVSLISVNDLMLQTKSIATRT---QEPFTWYIIAaaiYLVITLISQYILKRIELR 229
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
2-215 1.70e-17

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 77.56  E-value: 1.70e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247   2 NWDWSAVSDFMPHFWDGLLVTLQILVLGSAVSFALGLVWALLMRVPSRWVTWPIGVVTEFVRNTPLLVQLFFLFYVLPEW 81
Cdd:PRK15107    3 EFDWSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPGF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  82 NITFSALT--------TGVVAIGLHYSTYTMQVYRAGIEAVPVGQWEAATALNLPLRRTWTAVILPQAIRRVVPALGNYV 153
Cdd:PRK15107   83 LQNVLGLSpktdirliSAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQG 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1036810247 154 ISMLKDTPLLMAITVLEMLGEARLFSQQNFQFTEPLTVIGVAFIIISYLASLALRALERRLV 215
Cdd:PRK15107  163 IVLFQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKKRTV 224
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 19-205 2.84e-16

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 73.47  E-value: 2.84e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  19 LLVTLQILVLGSAVSFALGLVWALLMRVPSRWVTWPIGVVTEFVRNTPLLVQLFFLFYVLP---EWNITFSALTTGVVAI 95
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGvllGWGILPGLGLPALILA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  96 GLHYSTYTMQVYRAGIEAVPVGQWEAATALNLPLRRTWTAVILPQAIRRVVPALGNYVISMLKDTPLLMAITVLEMLGEA 175
Cdd:cd06261    81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                         170       180       190
                  ....*....|....*....|....*....|
gi 1036810247 176 RLFSQQNFQFTEPLTVIGVAFIIISYLASL 205
Cdd:cd06261   161 TGLLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 37-214 1.07e-11

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 61.16  E-value: 1.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  37 GLVWALLM-RVPSRWVTWPIGVVTEFVRNTPLLVQLFFLFYVlPEWNITFSALTTGVVAIGLHYSTYTMQVYRAGIEAVP 115
Cdd:pfam00528   1 GIPLGIIAaLRRGRRLDRLLRPLIDLLQALPSFVLAILLVVI-AILSILGHGILPAIILALLGWAGYARLIRRAALRSLP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247 116 VGQWEAATALNLPLRRTWTAVILPQAIRRVVPALGNYVISMLKDTPLLMAITVLEMLGEARLFSQQNFQFTE---PLTVI 192
Cdd:pfam00528  80 SDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEiqgPVLAA 159

                         170       180
                  ....*....|....*....|..
gi 1036810247 193 GVAFIIISYLASLALRALERRL 214
Cdd:pfam00528 160 ALILLLLNLLVDILQRLLDPRV 181
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 13-166 1.90e-11

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 62.47  E-value: 1.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  13 PHFWDGLLVTLQILVLGSAVSFALGLvWA--LLMRVPSRWVTWPIGVVTEFVrnTPLLVqlFFLFYVLPEWNI------- 83
Cdd:COG4597   180 PVFEPGFGWVLAALLAAIVAAFVLRR-WArrRQEATGQRFPVWWISLALLVG--LPLLA--FLLLGAPLSLDYpelkgfn 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  84 ---------TFSALTTGVVaigLHYSTYTMQVYRAGIEAVPVGQWEAATALNLPLRRTWTAVILPQAIRRVVPALGNYVI 154
Cdd:COG4597   255 frggltlspEFVALLLALS---LYTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQALRVIIPPLTSQYL 331

                         170
                  ....*....|..
gi 1036810247 155 SMLKDTPLLMAI 166
Cdd:COG4597   332 NLTKNSSLAVAI 343
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
17-213 4.02e-11

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 60.19  E-value: 4.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  17 DGLLVTLQILVLGSAVSFALGLVWALLMRVPSRWVTWPIGVVTEFVRNTPLLVQLFFLFY-----------VLPEWNITF 85
Cdd:PRK15135   11 QGALVTLELALSSVVLAVIIGLIGAGGKLSQNRLLGLIFEGYTTLIRGVPDLVLMLLIFYglqialnsvteALGVGQIDI 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  86 SALTTGVVAIGLHYSTYTMQVYRAGIEAVPVGQWEAATALNLPLRRTWTAVILPQAIRRVVPALGNYVISMLKDTPLLMA 165
Cdd:PRK15135   91 DPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATALVSL 170

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1036810247 166 ITVLEMLGEARLFSQQNFQFTEPLTVIGVAFIIISYLASLALRALERR 213
Cdd:PRK15135  171 LGLEDVVKATQLAGKSTWEPFYFAIVCGVIYLVFTTVSNGVLLWLERR 218
PhnE COG3639
ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport ...
 1-146 3.80e-06

ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 442856 [Multi-domain]  Cd Length: 244  Bit Score: 46.23  E-value: 3.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247   1 MNWDWSavsdFMPHFWDGLLVTLQILVLGSAVSFALGLVWALLM---RVPSRWVTWPIGVVTEFVRNTP-LLVQLFFLFY 76
Cdd:COG3639    39 FPPDWS----YLPDLLSALLETLAIALLGTLLGAVLALPLAFLAarnLAPNPWVRLLARRLLNVLRAIPeLVWALIFVAA 114

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  77 VLPewnitfsALTTGVVAIGLHYSTYTMQVYRAGIEAVPVGQWEAATALNLPLRRTWTAVILPQAIRRVV 146
Cdd:COG3639   115 VGL-------GPFAGVLALAIHTIGFLGKLFAEAIEEIDPGPVEALRATGASRLQVIRYGVLPQVLPQFL 177
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 15-216 3.52e-05

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 43.21  E-value: 3.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  15 FWDGLLVTLQILVLGSAVSFALGLVWALLMRVpSRWVTWPIGVVTEFVRNTPLLVqLFFLFYVLpewnitFSALTTGVVA 94
Cdd:COG0600    59 LWEHLLASLLRVLLGFALAALLGVPLGLLLGL-SRLLRRLLDPLLVFLRPIPPLA-LAPLLILW------FGIGEASKIF 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  95 IGLHYSTYTMQVY-RAGIEAVPVGQWEAATALNLPLRRTWTAVILPQAIRRVVPALgnyVISMlkdTPLLMAITVLEMLG 173
Cdd:COG0600   131 VIFLGAFFPILLNtAAGVRSVDPELLELARSLGASRWQILRKVVLPAALPYIFTGL---RIAL---GLAWIGLVVAELLG 204

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1036810247 174 EAR------LFSQQNFQFTEPLTVIgVAFIIISYLASLALRALERRLVH 216
Cdd:COG0600   205 ASSglgyliLDARQLLDTDLVFAAI-LVIGLLGLLLDLLLRLLERRLLR 252
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
3-213 1.01e-03

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 39.37  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247   3 WDWSAVSDFMPHFWDGLLVTLQILVLGSAVSFALGLVWALLMRVPSRWVTWPIGVVTEFVRNTPLLVQ---LFFLFYVLP 79
Cdd:COG1178   324 LDNYRFVLLDPSLLRALLNSLLLALLAALLAVLLALLLAYLVRRRRGRLARLLDRLAMLPYAVPGIVLglgLLLLFNRPL 403

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036810247  80 EWNITFSALTTgVVAIGLHYSTYTMQVYRAGIEAVPVGQWEAATALNLPLRRTWTAVILPQAIRRVVPALGNYVISMLKD 159
Cdd:COG1178   404 PLLLYGTLAIL-VLAYVVRFLPFALRSLEAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKE 482

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1036810247 160 TPL----------LMAITVLEMLGEARLfsqqnfqftEPLTVIGVAFIIISYLASLALRALERR 213
Cdd:COG1178   483 LSAtlllrppgfeTLAVLIYQLASSGRY---------GEAAALALLLVLVSLLPVLLLERLLGR 537
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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