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Conserved domains on  [gi|1040489335|ref|WP_065112067|]
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GNAT family N-acetyltransferase [Vibrio lentus]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10003213)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 30-121 1.52e-12

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


:

Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 60.39  E-value: 1.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040489335  30 ANKSEQIYSLELDGQLCGVVRFRTI-EDARLLTGMAISKEYRGKRLGSQLMDYCV-------LHTLtekdYCFAYSHLTN 101
Cdd:COG1246    24 EEEIGEFWVAEEDGEIVGCAALHPLdEDLAELRSLAVHPDYRGRGIGRRLLEALLaearelgLKRL----FLLTTSAAIH 99

                          90       100
                  ....*....|....*....|
gi 1040489335 102 FYNRHQFIQIDPNELPNGLR 121
Cdd:COG1246   100 FYEKLGFEEIDKEDLPYAKV 119
 
Name Accession Description Interval E-value
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 30-121 1.52e-12

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 60.39  E-value: 1.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040489335  30 ANKSEQIYSLELDGQLCGVVRFRTI-EDARLLTGMAISKEYRGKRLGSQLMDYCV-------LHTLtekdYCFAYSHLTN 101
Cdd:COG1246    24 EEEIGEFWVAEEDGEIVGCAALHPLdEDLAELRSLAVHPDYRGRGIGRRLLEALLaearelgLKRL----FLLTTSAAIH 99

                          90       100
                  ....*....|....*....|
gi 1040489335 102 FYNRHQFIQIDPNELPNGLR 121
Cdd:COG1246   100 FYEKLGFEEIDKEDLPYAKV 119
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 32-110 8.43e-09

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 49.38  E-value: 8.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040489335  32 KSEQIYSLELDGQLCGVVRFRTIEDARLLT--GMAISKEYRGKRLGSQLMDYCvLHTLTEKDYCFAYSHLTN----FYNR 105
Cdd:pfam13508   1 PGGRFFVAEDDGKIVGFAALLPLDDEGALAelRLAVHPEYRGQGIGRALLEAA-EAAAKEGGIKLLELETTNraaaFYEK 79


                  ....*
gi 1040489335 106 HQFIQ 110
Cdd:pfam13508  80 LGFEE 84
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 36-83 7.35e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 41.11  E-value: 7.35e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1040489335  36 IYSLELDGQLCGVVRFRTIEDAR---LLTGMAISKEYRGKRLGSQLMDYCV 83
Cdd:cd04301     1 FLVAEDDGEIVGFASLSPDGSGGdtaYIGDLAVLPEYRGKGIGSALLEAAE 51
PRK10314 PRK10314
GNAT family N-acetyltransferase;
65-113 8.31e-04

GNAT family N-acetyltransferase;


Pssm-ID: 182373 [Multi-domain]  Cd Length: 153  Bit Score: 37.52  E-value: 8.31e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1040489335  65 ISKEYRGKRLGSQLM----DYCVLHTLTEKDYCFAYSHLTNFYNRHQFIQIDP 113
Cdd:PRK10314   82 VSEALRGEKVGQQLMsktlESCTRHWPDKPVYLGAQAHLQNFYQSFGFIPVTE 134
 
Name Accession Description Interval E-value
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 30-121 1.52e-12

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 60.39  E-value: 1.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040489335  30 ANKSEQIYSLELDGQLCGVVRFRTI-EDARLLTGMAISKEYRGKRLGSQLMDYCV-------LHTLtekdYCFAYSHLTN 101
Cdd:COG1246    24 EEEIGEFWVAEEDGEIVGCAALHPLdEDLAELRSLAVHPDYRGRGIGRRLLEALLaearelgLKRL----FLLTTSAAIH 99

                          90       100
                  ....*....|....*....|
gi 1040489335 102 FYNRHQFIQIDPNELPNGLR 121
Cdd:COG1246   100 FYEKLGFEEIDKEDLPYAKV 119
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
39-111 9.12e-10

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 53.26  E-value: 9.12e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1040489335  39 LELDGQLCGVVRFRTIEDARL-LTGMAISKEYRGKRLGSQLMDYCVLHTLTEKD---YCFAYSHLTNFYNRHQFIQI 111
Cdd:COG2153    39 AYDDGELVATARLLPPGDGEAkIGRVAVLPEYRGQGLGRALMEAAIEEARERGArriVLSAQAHAVGFYEKLGFVPV 115
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 32-110 8.43e-09

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 49.38  E-value: 8.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040489335  32 KSEQIYSLELDGQLCGVVRFRTIEDARLLT--GMAISKEYRGKRLGSQLMDYCvLHTLTEKDYCFAYSHLTN----FYNR 105
Cdd:pfam13508   1 PGGRFFVAEDDGKIVGFAALLPLDDEGALAelRLAVHPEYRGQGIGRALLEAA-EAAAKEGGIKLLELETTNraaaFYEK 79


                  ....*
gi 1040489335 106 HQFIQ 110
Cdd:pfam13508  80 LGFEE 84
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 31-121 4.83e-07

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 45.72  E-value: 4.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040489335  31 NKSEQIYSLELDGQLCGVVRFRtieDARLLTGMAISKEYRGKRLGSQLMDYCVLHTLTEKDY-----CFAYSHLTNFYNR 105
Cdd:pfam13673  28 QGEYFFFVAFEGGQIVGVIALR---DRGHISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKlseltVNASPYAVPFYEK 104

                          90
                  ....*....|....*.
gi 1040489335 106 HQFIQIDPNELPNGLR 121
Cdd:pfam13673 105 LGFRATGPEQEFNGIR 120
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
40-119 3.38e-06

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 43.92  E-value: 3.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040489335  40 ELDGQLCGVVRFRTIE-----DARLLTGMAISKEYRGKRLGSQLMDYCvLHTLTEKDYCFAY----SHLTNFYNRHQFIQ 110
Cdd:COG3153    45 EDDGEIVGHVALSPVDidgegPALLLGPLAVDPEYRGQGIGRALMRAA-LEAARERGARAVVllgdPSLLPFYERFGFRP 123


                  ....*....
gi 1040489335 111 IDPNELPNG 119
Cdd:COG3153   124 AGELGLTLG 132
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 33-83 3.90e-06

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 43.28  E-value: 3.90e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1040489335  33 SEQIYSLELDGQLCGVVRFRTIEDARL---LTGMAISKEYRGKRLGSQLMDYCV 83
Cdd:pfam00583  32 SEGFFVAEEDGELVGFASLSIIDDEPPvgeIEGLAVAPEYRGKGIGTALLQALL 85
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 36-83 7.35e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 41.11  E-value: 7.35e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1040489335  36 IYSLELDGQLCGVVRFRTIEDAR---LLTGMAISKEYRGKRLGSQLMDYCV 83
Cdd:cd04301     1 FLVAEDDGEIVGFASLSPDGSGGdtaYIGDLAVLPEYRGKGIGSALLEAAE 51
PRK10314 PRK10314
GNAT family N-acetyltransferase;
65-113 8.31e-04

GNAT family N-acetyltransferase;


Pssm-ID: 182373 [Multi-domain]  Cd Length: 153  Bit Score: 37.52  E-value: 8.31e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1040489335  65 ISKEYRGKRLGSQLM----DYCVLHTLTEKDYCFAYSHLTNFYNRHQFIQIDP 113
Cdd:PRK10314   82 VSEALRGEKVGQQLMsktlESCTRHWPDKPVYLGAQAHLQNFYQSFGFIPVTE 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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