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Conserved domains on  [gi|1041866643|ref|WP_065228320|]
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MULTISPECIES: MarR family transcriptional regulator [Bacillus cereus group]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 229396)

helix-turn-helix domain-containing protein may bind DNA and be involved in the regulation of gene expression

Gene Ontology:  GO:0003677|GO:0006355

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_ARSR super family cl46857
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 31-137 4.54e-14

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


The actual alignment was detected with superfamily member smart00347:

Pssm-ID: 481197 [Multi-domain]  Cd Length: 101  Bit Score: 63.77  E-value: 4.54e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041866643   31 KFLRETGVSsmsLSELHVIECIGKNGLMNVTAITTEMGMTKGAISKICTKLFQKQFVEKMQMLDNQKEIFFSLTESGNEI 110
Cdd:smart00347   1 EELKPLGLT---PTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGREL 77

                           90       100
                   ....*....|....*....|....*..
gi 1041866643  111 YKAHEKLHKQAEEKwllLLDGYRKEEQ 137
Cdd:smart00347  78 IEQLLEARSETLAE---LLAGLTAEEQ 101
 
Name Accession Description Interval E-value
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
31-137 4.54e-14

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 63.77  E-value: 4.54e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041866643   31 KFLRETGVSsmsLSELHVIECIGKNGLMNVTAITTEMGMTKGAISKICTKLFQKQFVEKMQMLDNQKEIFFSLTESGNEI 110
Cdd:smart00347   1 EELKPLGLT---PTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGREL 77

                           90       100
                   ....*....|....*....|....*..
gi 1041866643  111 YKAHEKLHKQAEEKwllLLDGYRKEEQ 137
Cdd:smart00347  78 IEQLLEARSETLAE---LLAGLTAEEQ 101
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
4-150 2.42e-12

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 60.37  E-value: 2.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041866643   4 TTKQMEILSDIRTLLHKKEEHLKRQNEKFLRETGvssMSLSELHVIECIGKNGLMNVTAITTEMGMTKGAISKICTKLFQ 83
Cdd:COG1846     2 SDEPDPAEERLGLLLRRLARALRRALDRALAELG---LTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1041866643  84 KQFVEKMQMLDNQKEIFFSLTESGNEIYKAHEKLHKQAEEKwllLLDGYRKEEQDFIQRFIKDVSDH 150
Cdd:COG1846    79 KGLVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAE---LLAGLSEEELEALLRLLRRLAEN 142
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 41-99 1.84e-05

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 40.22  E-value: 1.84e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1041866643  41 MSLSELHVIECIGKNGLMNVTAITTEMGMTKGAISKICTKLFQKQFVEKMQMLDNQKEI 99
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
 
Name Accession Description Interval E-value
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
31-137 4.54e-14

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 63.77  E-value: 4.54e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041866643   31 KFLRETGVSsmsLSELHVIECIGKNGLMNVTAITTEMGMTKGAISKICTKLFQKQFVEKMQMLDNQKEIFFSLTESGNEI 110
Cdd:smart00347   1 EELKPLGLT---PTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGREL 77

                           90       100
                   ....*....|....*....|....*..
gi 1041866643  111 YKAHEKLHKQAEEKwllLLDGYRKEEQ 137
Cdd:smart00347  78 IEQLLEARSETLAE---LLAGLTAEEQ 101
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
4-150 2.42e-12

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 60.37  E-value: 2.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041866643   4 TTKQMEILSDIRTLLHKKEEHLKRQNEKFLRETGvssMSLSELHVIECIGKNGLMNVTAITTEMGMTKGAISKICTKLFQ 83
Cdd:COG1846     2 SDEPDPAEERLGLLLRRLARALRRALDRALAELG---LTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1041866643  84 KQFVEKMQMLDNQKEIFFSLTESGNEIYKAHEKLHKQAEEKwllLLDGYRKEEQDFIQRFIKDVSDH 150
Cdd:COG1846    79 KGLVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAE---LLAGLSEEELEALLRLLRRLAEN 142
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 41-99 1.84e-05

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 40.22  E-value: 1.84e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1041866643  41 MSLSELHVIECIGKNGLMNVTAITTEMGMTKGAISKICTKLFQKQFVEKMQMLDNQKEI 99
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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