|
Name |
Accession |
Description |
Interval |
E-value |
| TDT_C4-dicarb_trans |
cd09325 |
C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) ... |
9-307 |
4.78e-99 |
|
C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; This subfamily contains bacterial C4-dicarboxylate transporters, which is part of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family. It includes Tellurite resistance protein tehA; the tehA gene encodes an integral membrane protein that has been shown to have efflux activity of quaternary ammonium compounds. TehA protein of Escherichia coli functions as a tellurite-resistance uptake permease.
Pssm-ID: 187765 Cd Length: 293 Bit Score: 293.68 E-value: 4.78e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 9 NAPTPMAGLALGIASLGWSLENLGvfGGYAQITGAVIASVLLSVLAGKFLLHSHLLKQDLSHPVVGSVVPTFAMGCMVVS 88
Cdd:cd09325 1 KIPIPIAGLALGLASLGNLLELSY--GSILRNICGLIALILLILLLLKIILFPKTLKEELKNPVIASVFPTFPMALMLLS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 89 YAIGQHLAWLGNLMWVMSVALHIVFLVSFIFHRSQNFELHHMVPSWFVPPVGIVVAALTYSGSSSLHwIGEYTLYFGMAT 168
Cdd:cd09325 79 TYLKPFFPALAQLLWLLAIILHIILIIYFTYKRILKFNLEHVFPSWFVVYVGIVVASVTAPAFGQPL-LGQIAFWFGFVA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 169 YAVMLPVMIYRFIFSELVQDAAKPTIAILAAPASLSLAGYLSFVESPSPVIVALLFGIAILMTSVIYMAFYRLLRLPFSP 248
Cdd:cd09325 158 YLILLPLVLYRLVKIKELPDAALPTIAIFAAPASLCLAGYLNSFPEPNPVLVLFLLILSQLLYFFVLLQLPRLLKLPFYP 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1046205866 249 AYAAFTFPLVISATALFKVVAWMSEigvPAEYVEQVHGIALVELAVATLVVGYVAIQYL 307
Cdd:cd09325 238 SFAAFTFPLVISATALKKTSTYLAS---YGLYLPILKYLALFEILIATVIVLYVLIRYL 293
|
|
| TehA |
COG1275 |
Tellurite resistance protein TehA and related permeases [Defense mechanisms]; |
1-311 |
3.28e-64 |
|
Tellurite resistance protein TehA and related permeases [Defense mechanisms];
Pssm-ID: 440886 Cd Length: 323 Bit Score: 205.47 E-value: 3.28e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 1 MQTQSRLANAPTPMAGLALGIASLGWSLEN-------LGVFGGYAQITGAVIASVLLSVLAGKFLLHSHLLKQDLSHPVV 73
Cdd:COG1275 3 TAPRSRLRNLPPAWFALVMGTGGLGLAWRLaaallpgPAAIAEVLLALAALLFLVLLLLYLLKWLRYPAAVRADLRHPVR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 74 GSVVPTFAMGCMVVSYAIGQHLAWLGNLMWVMSVALHIVFLVSFIFH--RSQNFELHHMVPSWFVPPVGIVVAALTYSGS 151
Cdd:COG1275 83 GSFFPTIPMALLLLGTGLLPLAPALALVLWLLGVALHLALTVYFPYRlfTGEKFEIEHITPAWFIPVVGNIVVAVAGALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 152 SSLHWIGEYTLYFGMATYAVMLPVMIYRFIFSELVQDAAKPTIAILAAPASLSLAGYLSFVESPSPVIVALLFGIAILMT 231
Cdd:COG1275 163 GPLLELSYAFFGVGLFLYLVLLPLVLYRLIFHKPLPEALRPTLWILLAPPAVGLLAYLALGGGPLDGFALILWGFGLWWL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 232 SVIYMAFYRLLRLPFSPAYAAFTFPLVISATALFKVVAWMSeigvpaeyVEQVHGIALVELAVATLVVGYVAIQYLNNLL 311
Cdd:COG1275 243 LLLLLLTPRLLRLPFSPSWWAFTFPLAAYATATLRLAEATG--------LPFLAVLALALLVLATLVWLYVLVRTLRALA 314
|
|
| SLAC1 |
pfam03595 |
Voltage-dependent anion channel; This family of transporters has ten alpha helical ... |
40-266 |
6.41e-16 |
|
Voltage-dependent anion channel; This family of transporters has ten alpha helical transmembrane segments. The structure of a bacterial homolog of SLAC1 shows it to have a trimeric arrangement. The pore is composed of five helices with a conserved Phe residue involved in gating. One homolog, Mae1 from the yeast Schizosaccharomyces pombe, functions as a malate uptake transporter; another, Ssu1 from Saccharomyces cerevisiae and other fungi including Aspergillus fumigatus, is characterized as a sulfite efflux pump; and TehA from Escherichia coli is identified as a tellurite resistance protein by virtue of its association in the tehA/tehB operon. In plants, this family is found in the stomatal guard cells functioning as an anion-transporting pore. Many homologs are incorrectly annotated as tellurite resistance or dicarboxylate transporter (TDT) proteins.
Pssm-ID: 460983 Cd Length: 321 Bit Score: 76.89 E-value: 6.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 40 ITGAVIASVLLSVLAGKFLLHSHLLKQDLSHPVVGSVVPTFAMGCMVV---SYAIGQHLAWLGNLMWVM----SVALHIV 112
Cdd:pfam03595 38 ILNLVLFLLLLLLYLLRFILYPEAVRAELRHPVESLFLGTFPMGFATIingLVLVPVPGPWLVTLAWVLwwwiGVALALA 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 113 FLVSFIFH-RSQNFELHHMVPSWFVPPVGIVVAALTYS-GSSSLHWIGEYTLYF---GMATYAVMLPVMIYRFIFSELVQ 187
Cdd:pfam03595 118 FAVGVPFLlFTRHHLLEAMTPAWLLPVVPLMVVAALGAlLAALLLPILVVSYLLwglGLFLALVILAIYLYRLFTHGLPP 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 188 DAAKPTIAILAAPASLSLAGYLSFVESPSPV-------------IVALLFGIAILMTSVIYMAF--------YRLLRLPF 246
Cdd:pfam03595 198 AELRPSLFIPLGPPGQGALALLLLGGAAPTIlpaltalageilyVVALLLALFLWGFGLWWFFIaalsvlsaLRRGGLPF 277
|
250 260
....*....|....*....|
gi 1046205866 247 SPAYAAFTFPLVISATALFK 266
Cdd:pfam03595 278 NLGWWAFTFPLGAFALATIE 297
|
|
| tdt |
TIGR00816 |
C4-dicarboxylate transporter/malic acid transport protein; The Tellurite-Resistance ... |
12-262 |
1.12e-13 |
|
C4-dicarboxylate transporter/malic acid transport protein; The Tellurite-Resistance/Dicarboxylate Transporter (TDT) Family (TC 2.A.16)Two members of the TDT family have been functionally characterized. One is the TehA protein of E. coli which has been implicated in resistance to tellurite; the other is the Mae1 protein of S. pombe which functions in the uptake of malate and other dicarboxylates by a proton symportmechanism. These proteins exhibit 10 putative transmembrane a-helicalspanners (TMSs). [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273285 Cd Length: 320 Bit Score: 70.51 E-value: 1.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 12 TPMAGLALGIASLGWS-----LENLGVFGGYAQItgaVIASVLLSVLAGKFLLHSHLLKQDLSHPVVGSVVPTFAMGCMV 86
Cdd:TIGR00816 8 IVLGTGGLALASLSYSfylpiLKDLSDVLFILAI---ALFFLFTSCWLARLIRYPSNVLAELKHPVLSSFIPLIPISTML 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 87 VS---YAIGQHLAWLgnlMWVMSVALHIVF--LVSFIFHRSQNFELHHMVPSWFVPPVG---IVVAALTYSGSSSLHWIG 158
Cdd:TIGR00816 85 LGidfIIWGYPLALG---LWYIGAIGQLLFsvIVPFYLFKNESIEIEHTHPGWYLPPVAlifISAAALAILPYLTHELTV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 159 EYTLYFG--MATYAVMLPVMIYRFIFSELVQDAAKPTIAILAAPASLSLAGYLS--------FVESPSPVIVALLFGIAI 228
Cdd:TIGR00816 162 LFYFGWGagFFLYLSLEAVLLLRLRLHGLLPSALRPTMFINLAPIGVGIVALINivnhgefiTIKEPFLILAIILWGFGL 241
|
250 260 270
....*....|....*....|....*....|....*.
gi 1046205866 229 --LMTSVIYMAFYRLLRLPFSPAYAAFTFPLVISAT 262
Cdd:TIGR00816 242 wqLLFAIRLLLWYVKLKLPFAMGWWAFIFPLAAYAN 277
|
|
| PRK10764 |
PRK10764 |
potassium-tellurite ethidium and proflavin transporter; Provisional |
40-316 |
6.15e-06 |
|
potassium-tellurite ethidium and proflavin transporter; Provisional
Pssm-ID: 236756 Cd Length: 324 Bit Score: 47.25 E-value: 6.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 40 ITGAVIASVLLSVLAGKFLLHSHLLKQDLSHPVVGSVVPTFAMGCMVVSYAIGQHLAWLGNLMWVMSVALHIVFLVSFIF 119
Cdd:PRK10764 46 ALASIIWALLILAYLYKWIRFPESVLAELRHPVQSSFVSLIPITTMLVAIGLVPYSRPLAVVLFSFGVVGQLAFAAWRTA 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 120 HRSQ-NFELHHMVPSWFVPPVGIVVAALTYSGSSSLHWIGEYTLYFGMATYAVMLPVMIYRFIFSELVQDAAKPTIAILA 198
Cdd:PRK10764 126 GLWRgGHPEEATTPGLYLPTVANNFVSAMALGALGYHDAGLLFLGAGVFSWLSLEPVILQRLRSSGELPTALRPSLGIQL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 199 APASLSLAGYLSFVESPSPVIVALLFGIAILMTSVIYMAFYRLLRLPFSPAYAAFTFPLVISATALFKVVAwMSEIGVpa 278
Cdd:PRK10764 206 APAFVGCSAYLSVNGGEGDTLAKMLFGYGLLQLLFLLRLMPWILSQGFNASFWSFSFGVAALATTGLHLGH-GSDNGF-- 282
|
250 260 270
....*....|....*....|....*....|....*...
gi 1046205866 279 eyveqVHGIALVELAVATLVVGYVAIQYLnNLLIQPRL 316
Cdd:PRK10764 283 -----FHTLAVPLFIFANFIIALLLLRTL-ALLMQGKL 314
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TDT_C4-dicarb_trans |
cd09325 |
C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) ... |
9-307 |
4.78e-99 |
|
C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; This subfamily contains bacterial C4-dicarboxylate transporters, which is part of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family. It includes Tellurite resistance protein tehA; the tehA gene encodes an integral membrane protein that has been shown to have efflux activity of quaternary ammonium compounds. TehA protein of Escherichia coli functions as a tellurite-resistance uptake permease.
Pssm-ID: 187765 Cd Length: 293 Bit Score: 293.68 E-value: 4.78e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 9 NAPTPMAGLALGIASLGWSLENLGvfGGYAQITGAVIASVLLSVLAGKFLLHSHLLKQDLSHPVVGSVVPTFAMGCMVVS 88
Cdd:cd09325 1 KIPIPIAGLALGLASLGNLLELSY--GSILRNICGLIALILLILLLLKIILFPKTLKEELKNPVIASVFPTFPMALMLLS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 89 YAIGQHLAWLGNLMWVMSVALHIVFLVSFIFHRSQNFELHHMVPSWFVPPVGIVVAALTYSGSSSLHwIGEYTLYFGMAT 168
Cdd:cd09325 79 TYLKPFFPALAQLLWLLAIILHIILIIYFTYKRILKFNLEHVFPSWFVVYVGIVVASVTAPAFGQPL-LGQIAFWFGFVA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 169 YAVMLPVMIYRFIFSELVQDAAKPTIAILAAPASLSLAGYLSFVESPSPVIVALLFGIAILMTSVIYMAFYRLLRLPFSP 248
Cdd:cd09325 158 YLILLPLVLYRLVKIKELPDAALPTIAIFAAPASLCLAGYLNSFPEPNPVLVLFLLILSQLLYFFVLLQLPRLLKLPFYP 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1046205866 249 AYAAFTFPLVISATALFKVVAWMSEigvPAEYVEQVHGIALVELAVATLVVGYVAIQYL 307
Cdd:cd09325 238 SFAAFTFPLVISATALKKTSTYLAS---YGLYLPILKYLALFEILIATVIVLYVLIRYL 293
|
|
| TehA |
COG1275 |
Tellurite resistance protein TehA and related permeases [Defense mechanisms]; |
1-311 |
3.28e-64 |
|
Tellurite resistance protein TehA and related permeases [Defense mechanisms];
Pssm-ID: 440886 Cd Length: 323 Bit Score: 205.47 E-value: 3.28e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 1 MQTQSRLANAPTPMAGLALGIASLGWSLEN-------LGVFGGYAQITGAVIASVLLSVLAGKFLLHSHLLKQDLSHPVV 73
Cdd:COG1275 3 TAPRSRLRNLPPAWFALVMGTGGLGLAWRLaaallpgPAAIAEVLLALAALLFLVLLLLYLLKWLRYPAAVRADLRHPVR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 74 GSVVPTFAMGCMVVSYAIGQHLAWLGNLMWVMSVALHIVFLVSFIFH--RSQNFELHHMVPSWFVPPVGIVVAALTYSGS 151
Cdd:COG1275 83 GSFFPTIPMALLLLGTGLLPLAPALALVLWLLGVALHLALTVYFPYRlfTGEKFEIEHITPAWFIPVVGNIVVAVAGALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 152 SSLHWIGEYTLYFGMATYAVMLPVMIYRFIFSELVQDAAKPTIAILAAPASLSLAGYLSFVESPSPVIVALLFGIAILMT 231
Cdd:COG1275 163 GPLLELSYAFFGVGLFLYLVLLPLVLYRLIFHKPLPEALRPTLWILLAPPAVGLLAYLALGGGPLDGFALILWGFGLWWL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 232 SVIYMAFYRLLRLPFSPAYAAFTFPLVISATALFKVVAWMSeigvpaeyVEQVHGIALVELAVATLVVGYVAIQYLNNLL 311
Cdd:COG1275 243 LLLLLLTPRLLRLPFSPSWWAFTFPLAAYATATLRLAEATG--------LPFLAVLALALLVLATLVWLYVLVRTLRALA 314
|
|
| TDT_TehA_like |
cd09322 |
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA proteins; The ... |
11-301 |
2.05e-62 |
|
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA proteins; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane a-helical spanners (TMSs).
Pssm-ID: 187762 Cd Length: 289 Bit Score: 199.69 E-value: 2.05e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 11 PTPMAGLALGIASLGWSLEnLGVFGGYAQITGAvIASVLLSVLAGKFLL----HSHLLKQDLSHPVVGSVVPTFAMGCMV 86
Cdd:cd09322 3 PIVLGLLGLGLAWLGALLL-LGLPSIVGEILGI-LALLLWLLLLLKYLLkllrYPEAVKAELRHPVRASFFATFSMSLML 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 87 VSYAIGQHLAWLGNLMWVMSVALHIVFLVSFIFHRSQNF-ELHHMVPSWFVPPVGIVVAALTYSGSSSLHWiGEYTLYFG 165
Cdd:cd09322 81 LSIYLLPYSPLLARVLWILGAVLHLVFTLYFVSRWIRGGkFLEHVTPSWFIPYVGNIVVPVTGPALGGPEL-GWFFFGVG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 166 MATYAVMLPVMIYRFIFSELVQDAAKPTIAILAAPASLSLAGYLSFVESPSPVIVALLFGIAILMTSVIYMAFYRLLRLP 245
Cdd:cd09322 160 LIFWLVLLPLVLYRLIFHEPLPEPLRPTLAILLAPPSLGLAAYLALFGGPIDLFALILLGLALFLFLLLLRLLPRLLKLP 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1046205866 246 FSPAYAAFTFPLVISATALFKVVAWMseigvpAEYVEQVHGIALVELAVATLVVGY 301
Cdd:cd09322 240 FSPSWWAFTFPLAALAIALLKMAAYL------GSGFLQLLALVLLELLTAVILVLY 289
|
|
| TDT_SLAC1_like |
cd09323 |
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion ... |
11-304 |
5.16e-25 |
|
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); SLAC1 (Slow Anion Channel-Associated 1) is a plasma membrane protein, preferentially expressed in guard cells, which encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. It is essential for stomatal closure in response to carbon dioxide, abscisic acid, ozone, light/dark transitions, humidity change, calcium ions, hydrogen peroxide and nitric oxide. In the Arabidopsis genome, SLAC1 is part of a gene family with five members and encodes a membrane protein that has ten putative transmembrane domains flanked by large N- and C-terminal domains. Mutations in SLAC1 impair slow (S-type) anion channel currents that are activated by cytosolic calcium ions and abscisic acid, but do not affect rapid (R-type) anion channel currents or calcium ion channel function.
Pssm-ID: 187763 Cd Length: 297 Bit Score: 101.86 E-value: 5.16e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 11 PTPMAGLALGIASLGWSLENLGVFGGYAQITGAVIAS-------VLLSVLAGKFLLHSHLLKQDLSHPVVGSVVPTFAMG 83
Cdd:cd09323 3 PVSLFAIVMGLSGLALAWRKAAELLGLPAAISEALGWlavavfvVLAALYALKILRYPEAVKAEFNHPVRINFFPAISIS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 84 CMVVSYAIGQHLAWLGNLMWVMSVALHIVF---LVSFIFHRSQnFELHHMVPSWFVPPVGIVVAALTysgSSSLHWIGEY 160
Cdd:cd09323 83 LLLLSIALLPYSPVLALALWIIGAVLQLALtlyVVSRWISHRQ-FQIGHANPAWFIPVVGNLVVPIA---GVPLGYAEVS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 161 TLYF--GMATYAVMLPVMIYRFIFSELVQDAAKPTIAILAAPASLSLAGYLSFVESPSPViVALLFGIAILMTSVIYMAF 238
Cdd:cd09323 159 WFFFsvGLFFWLVLFTIVFNRLIFHEPLPAKLLPTLFILIAPPAVGFLAYLKLTGSLDAF-ARILYYIALFLFLLLLFQV 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1046205866 239 YRLLRLPFSPAYAAFTFPLVISATALFKVvawmseigvpAEYVEQV--HGIALVELAVATLVVGYVAI 304
Cdd:cd09323 238 RRFRKLPFFLSWWAYSFPLAALAIATLRM----------AELTGSLflQVLALVLLALLTLVVAVLLV 295
|
|
| TDT_like_3 |
cd09321 |
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance ... |
14-267 |
1.91e-19 |
|
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane a-helical spanners (TMSs).
Pssm-ID: 187761 Cd Length: 327 Bit Score: 86.97 E-value: 1.91e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 14 MAGLALGIASLGWSLENlgVFGGYAQITGAVIASVLLSVLAG----KFLLHSHLLKQDLSHPVVGSVVPTFAMGCMVVSY 89
Cdd:cd09321 10 MGTGALAIASYLYSAYF--PFLKTLAVFLTYLNFLLFFVLLVpwllRWILYPKEALADLKHPVLSNFYPTMPIALLVLAT 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 90 AI-----GQHLAWLGNLMWVMSVALHIVF--LVSFIFHRSQNFELHHMVPSWFVPPVGIVVAAL---------TYSGSSS 153
Cdd:cd09321 88 NIlivgqGPLGYSLALTLWILGSILIFIFsfIVSYIMFINEEIPIEHINPAWFIPPVGLIVIPLagnfliphfPGAWQES 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 154 LHWIGEYTLYFGMATYAVMLPVMIYRFIFSELVQDAAKPTIAILAAPASLSLAGYLSFVE-----------SPSPVIVAL 222
Cdd:cd09321 168 ILVINLFGFGIGFFLFLFLLAIILHRLILHEPPPPELAPTFWINLAPIGAGVVALINLVKalpfaglenlvDLANIFALI 247
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1046205866 223 L--FGIAILMTSVIYMAFY-RLLRLPFSPAYAAFTFPLVISATALFKV 267
Cdd:cd09321 248 LwgFGLWWLILAVLLTLYYlKRGNLPFSLGWWAFIFPLGAYTIATYLV 295
|
|
| SLAC1 |
pfam03595 |
Voltage-dependent anion channel; This family of transporters has ten alpha helical ... |
40-266 |
6.41e-16 |
|
Voltage-dependent anion channel; This family of transporters has ten alpha helical transmembrane segments. The structure of a bacterial homolog of SLAC1 shows it to have a trimeric arrangement. The pore is composed of five helices with a conserved Phe residue involved in gating. One homolog, Mae1 from the yeast Schizosaccharomyces pombe, functions as a malate uptake transporter; another, Ssu1 from Saccharomyces cerevisiae and other fungi including Aspergillus fumigatus, is characterized as a sulfite efflux pump; and TehA from Escherichia coli is identified as a tellurite resistance protein by virtue of its association in the tehA/tehB operon. In plants, this family is found in the stomatal guard cells functioning as an anion-transporting pore. Many homologs are incorrectly annotated as tellurite resistance or dicarboxylate transporter (TDT) proteins.
Pssm-ID: 460983 Cd Length: 321 Bit Score: 76.89 E-value: 6.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 40 ITGAVIASVLLSVLAGKFLLHSHLLKQDLSHPVVGSVVPTFAMGCMVV---SYAIGQHLAWLGNLMWVM----SVALHIV 112
Cdd:pfam03595 38 ILNLVLFLLLLLLYLLRFILYPEAVRAELRHPVESLFLGTFPMGFATIingLVLVPVPGPWLVTLAWVLwwwiGVALALA 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 113 FLVSFIFH-RSQNFELHHMVPSWFVPPVGIVVAALTYS-GSSSLHWIGEYTLYF---GMATYAVMLPVMIYRFIFSELVQ 187
Cdd:pfam03595 118 FAVGVPFLlFTRHHLLEAMTPAWLLPVVPLMVVAALGAlLAALLLPILVVSYLLwglGLFLALVILAIYLYRLFTHGLPP 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 188 DAAKPTIAILAAPASLSLAGYLSFVESPSPV-------------IVALLFGIAILMTSVIYMAF--------YRLLRLPF 246
Cdd:pfam03595 198 AELRPSLFIPLGPPGQGALALLLLGGAAPTIlpaltalageilyVVALLLALFLWGFGLWWFFIaalsvlsaLRRGGLPF 277
|
250 260
....*....|....*....|
gi 1046205866 247 SPAYAAFTFPLVISATALFK 266
Cdd:pfam03595 278 NLGWWAFTFPLGAFALATIE 297
|
|
| tdt |
TIGR00816 |
C4-dicarboxylate transporter/malic acid transport protein; The Tellurite-Resistance ... |
12-262 |
1.12e-13 |
|
C4-dicarboxylate transporter/malic acid transport protein; The Tellurite-Resistance/Dicarboxylate Transporter (TDT) Family (TC 2.A.16)Two members of the TDT family have been functionally characterized. One is the TehA protein of E. coli which has been implicated in resistance to tellurite; the other is the Mae1 protein of S. pombe which functions in the uptake of malate and other dicarboxylates by a proton symportmechanism. These proteins exhibit 10 putative transmembrane a-helicalspanners (TMSs). [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273285 Cd Length: 320 Bit Score: 70.51 E-value: 1.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 12 TPMAGLALGIASLGWS-----LENLGVFGGYAQItgaVIASVLLSVLAGKFLLHSHLLKQDLSHPVVGSVVPTFAMGCMV 86
Cdd:TIGR00816 8 IVLGTGGLALASLSYSfylpiLKDLSDVLFILAI---ALFFLFTSCWLARLIRYPSNVLAELKHPVLSSFIPLIPISTML 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 87 VS---YAIGQHLAWLgnlMWVMSVALHIVF--LVSFIFHRSQNFELHHMVPSWFVPPVG---IVVAALTYSGSSSLHWIG 158
Cdd:TIGR00816 85 LGidfIIWGYPLALG---LWYIGAIGQLLFsvIVPFYLFKNESIEIEHTHPGWYLPPVAlifISAAALAILPYLTHELTV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 159 EYTLYFG--MATYAVMLPVMIYRFIFSELVQDAAKPTIAILAAPASLSLAGYLS--------FVESPSPVIVALLFGIAI 228
Cdd:TIGR00816 162 LFYFGWGagFFLYLSLEAVLLLRLRLHGLLPSALRPTMFINLAPIGVGIVALINivnhgefiTIKEPFLILAIILWGFGL 241
|
250 260 270
....*....|....*....|....*....|....*.
gi 1046205866 229 --LMTSVIYMAFYRLLRLPFSPAYAAFTFPLVISAT 262
Cdd:TIGR00816 242 wqLLFAIRLLLWYVKLKLPFAMGWWAFIFPLAAYAN 277
|
|
| TDT_TehA |
cd09324 |
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; This ... |
11-304 |
1.93e-12 |
|
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; This subfamily includes Tellurite resistance protein TehA that belongs to the C4-dicarboxylate transporter/malic acid transport (TDT) protein family and is a homolog of plant Slow Anion Channel-Associated 1 (SLAC1). The tehA gene encodes an integral membrane protein that has been shown to have efflux activity of quaternary ammonium compounds. TehA protein of Escherichia coli functions as a tellurite-resistance uptake permease.
Pssm-ID: 187764 Cd Length: 301 Bit Score: 66.52 E-value: 1.93e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 11 PTPMAGLALGIASLGWSLENLGVFGGYAQITG-------AVIASVLLSVLAGKFLLHSHLLKQDLSHPVVGSVVPTFAMG 83
Cdd:cd09324 1 PVGYFGIVLGLAALGLAWRYAAQLWPLPAIVGesllalaSVVWLLLIGAYAYKWLKYREEARAELRHPVQCCFISLIPIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 84 CMVVSYAIGQHLAWLGNLMWVMSVALHIVFLVSFIFHRSQ-NFELHHMVPSWFVPPVGIVVAALTYSGSSSLHWIGEYTL 162
Cdd:cd09324 81 TMLVGIALYPYSRLLAEVLIVLGIIGQLAFAAWRTGGLWQgGHFPEATTPVLYLPTVAGNFVSASALAALGYHDLGMLFF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 163 YFGMATYAVMLPVMIYRFIFSELVQDAAKPTIAILAAPASLSLAGYLSFVESPSPVIVALLFGIAILMTSVIYMAFYRLL 242
Cdd:cd09324 161 GAGMFSWLSLEPVILQRLRTSPPLPPALRPTLGIQLAPAFVGCSAYLSLNGGEVDLLAKMLWGYGLLQLLFLLRLLPWIA 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046205866 243 RLPFSPAYAAFTFPLVISATALFKVVAwmseigvpAEYVEQVHGIALVELAVATLVVGYVAI 304
Cdd:cd09324 241 EQGFSMGFWAFSFGLAAMATSGLHLYH--------GGVLGPLSLLALALFNVANGLIALLTL 294
|
|
| TDT |
cd09299 |
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance ... |
44-263 |
3.15e-08 |
|
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane alpha-helical spanners (TMSs).
Pssm-ID: 187756 Cd Length: 326 Bit Score: 54.26 E-value: 3.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 44 VIASVLLSVLAGKFLLH-----SHLLKQDLSHPVVGSVVPTFAMGCMVVS--YAIGQHLAWLGNLMWVMSVALHI----- 111
Cdd:cd09299 34 ILAIVIFILFFALWLLRlirypRHVVRESHHNPVEASFLAAVPISLFTIIdfLALYGGANTGRLVILIAYVLWWIglals 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 112 ---VFLVSFIFHRSQNFELHHMVPSWFVPPVGIVVAA---LTYSGSSSLHWIGEYTLYFGMAT-------YAVMLPVMIY 178
Cdd:cd09299 114 lvsAVGVPYLLFTNHVYEIEHISPAWLLPIVPPMTSAalaGALLPYSPGGAIQLSVIFLGYLFfgigfflFIFIGAIIFS 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 179 RFIFSELVQDAAKPTIAILAAPASLSLAGYLS---------FVESPSPVIVALLFGIAILMTSV------IYMAFYRLL- 242
Cdd:cd09299 194 RLVINKLPPGQLAPTLMIVLGPMGQSIFALLLlgknarlifFLYASFLQALAVFASIILWGFGLwwlllaLVSILRTLRk 273
|
250 260
....*....|....*....|.
gi 1046205866 243 RLPFSPAYAAFTFPLVISATA 263
Cdd:cd09299 274 KLPFSLGWWSYVFPLGVYTNG 294
|
|
| PRK10764 |
PRK10764 |
potassium-tellurite ethidium and proflavin transporter; Provisional |
40-316 |
6.15e-06 |
|
potassium-tellurite ethidium and proflavin transporter; Provisional
Pssm-ID: 236756 Cd Length: 324 Bit Score: 47.25 E-value: 6.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 40 ITGAVIASVLLSVLAGKFLLHSHLLKQDLSHPVVGSVVPTFAMGCMVVSYAIGQHLAWLGNLMWVMSVALHIVFLVSFIF 119
Cdd:PRK10764 46 ALASIIWALLILAYLYKWIRFPESVLAELRHPVQSSFVSLIPITTMLVAIGLVPYSRPLAVVLFSFGVVGQLAFAAWRTA 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 120 HRSQ-NFELHHMVPSWFVPPVGIVVAALTYSGSSSLHWIGEYTLYFGMATYAVMLPVMIYRFIFSELVQDAAKPTIAILA 198
Cdd:PRK10764 126 GLWRgGHPEEATTPGLYLPTVANNFVSAMALGALGYHDAGLLFLGAGVFSWLSLEPVILQRLRSSGELPTALRPSLGIQL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 199 APASLSLAGYLSFVESPSPVIVALLFGIAILMTSVIYMAFYRLLRLPFSPAYAAFTFPLVISATALFKVVAwMSEIGVpa 278
Cdd:PRK10764 206 APAFVGCSAYLSVNGGEGDTLAKMLFGYGLLQLLFLLRLMPWILSQGFNASFWSFSFGVAALATTGLHLGH-GSDNGF-- 282
|
250 260 270
....*....|....*....|....*....|....*...
gi 1046205866 279 eyveqVHGIALVELAVATLVVGYVAIQYLnNLLIQPRL 316
Cdd:PRK10764 283 -----FHTLAVPLFIFANFIIALLLLRTL-ALLMQGKL 314
|
|
| TDT_Mae1_like |
cd09317 |
C4-dicarboxylate transporter/malic acid transport protein family includes Mae1; This family ... |
40-210 |
2.98e-03 |
|
C4-dicarboxylate transporter/malic acid transport protein family includes Mae1; This family contains eukaryotic homologs of C4-dicarboxylate transporter/malic acid transport proteins which are part of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family. This includes the MAE1 gene in Schizosaccharomyces pombe gene that encodes malate permease, Mae1, which functions by proton symport and transports C4-dicarboxylates (malate, fumarate, succinate, oxaloacetate, etc.), but not K-ketoglutarate.
Pssm-ID: 187757 Cd Length: 330 Bit Score: 38.77 E-value: 2.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 40 ITGAVIASVLLSVLAGKFLLHSHLLKQDLSHPVVGSVVPTF-----AMGCMVVSYAIGQHLAWLGNLMWV---MSVALHI 111
Cdd:cd09317 34 ILNLILFTLITLCLILRFILYPGTFLASLTHPTEGLFVPTFllsiaTIIIGTQSYGVPSCGPWLVTALRVlfwIYVALSL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 112 ---VFLVSFIFHRSQnFELHHMVPSWFVP--------PVGIVVAALTYSGSSSLHWIGEYTLY-FGMATYAVMLPVMIYR 179
Cdd:cd09317 114 ivaIGQYLLLFSTHT-FPLTTMTPAWILPifplmltgTIASVLAASQPPSSAVPMIVAGLTFQgLGFLMSLFIYAVYIGR 192
|
170 180 190
....*....|....*....|....*....|.
gi 1046205866 180 FIFSELVQDAAKPTIAILAAPASLSLAGYLS 210
Cdd:cd09317 193 LMTSGLPAPSQRPGMFIAVGPPGFTALALIG 223
|
|
| TDT_SSU1 |
cd09318 |
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity ... |
44-145 |
6.34e-03 |
|
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); This family contains the sulfite sensitivity protein (sulfite efflux pump; SSU1) and belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family. The SSU1 gene encodes the sulfite pump required for efficient sulfite efflux. Mutations in the SSU1 gene cause sensitivity to sulfite while overexpression confers heightened resistance to sulfite toxicity. In dematophytes and other filamentous fungi, sulfite is excreted as a reducing agent during keratin degradation; thus sulfite transporters in keratinolytic fungi could be a new target for antifungal drugs in dermatology. The number of genes encoding sulfite efflux pumps in fungal genomes varies from species to species.
Pssm-ID: 187758 Cd Length: 341 Bit Score: 37.94 E-value: 6.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046205866 44 VIASVLLSVLAGKFLLHSHLLKQDLSHPVVGSVVPTFAMG--------CMVVSYAIGQHLAWLGNLMWVMSVALHI---V 112
Cdd:cd09318 46 LLFILFTVLFIARYVLYPERFRAMLKHPTQSLFLGTIPMGlatiingiVLLCGPVWGPWAIILAWVLWWIDVALSLataW 125
|
90 100 110
....*....|....*....|....*....|...
gi 1046205866 113 FLVSFIFHRSQNFELHHMVPSWFVPPVGIVVAA 145
Cdd:cd09318 126 GVPFLMFTRQNKHALEKMTAVWLLPIVALVVAA 158
|
|
| |
