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Conserved domains on  [gi|1046555798|ref|WP_065655211|]
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MULTISPECIES: multidrug effflux MFS transporter [Rhizobium/Agrobacterium group]

Protein Classification

multidrug effflux MFS transporter( domain architecture ID 13022939)

multidrug resistance (MDR) MFS transporter is a drug/H+ antiporter (DHA) that mediates the efflux of one or more from a variety of drugs and toxic compounds, and confer resistance to these compounds

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 7-387 5.47e-93

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 284.08  E-value: 5.47e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798   7 IALAAMLMALNALAIDIMLPGLQEIGASLGVeNENHRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAI 86
Cdd:cd17320     1 LLLLALLVALGPLAIDMYLPALPAIARDLGA-SASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  87 AVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHLIFAFM 166
Cdd:cd17320    80 LCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 167 AAIAAVVTAWMYFRLPETLHPDDIRPLtASSILGGFKIVLTNRIALCYTLSSTFIFGALFGFINSVEQVYKGIYGLGAWF 246
Cdd:cd17320   160 ALLGLLLLLLVLLFLPETLPEEKRKPL-LSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQ 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 247 -AAAFAGVALFMAFSSFVNARLVGRFGMRKLSHGSLLGFIAITFVWLLVQVLGpePMPFAIFIVFFALAMFQFGWIGSNF 325
Cdd:cd17320   239 fGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLG--GLSLWPLVAPLFLIFFGFGLIFPNA 316

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046555798 326 NSLAMEPLGHVAGTASSVMGFMGTVGGSLIGAAIGQSFDGTALPMVAGFFAVSIVGLIFVLI 387
Cdd:cd17320   317 TSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLIL 378
 
Name Accession Description Interval E-value
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 7-387 5.47e-93

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 284.08  E-value: 5.47e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798   7 IALAAMLMALNALAIDIMLPGLQEIGASLGVeNENHRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAI 86
Cdd:cd17320     1 LLLLALLVALGPLAIDMYLPALPAIARDLGA-SASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  87 AVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHLIFAFM 166
Cdd:cd17320    80 LCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 167 AAIAAVVTAWMYFRLPETLHPDDIRPLtASSILGGFKIVLTNRIALCYTLSSTFIFGALFGFINSVEQVYKGIYGLGAWF 246
Cdd:cd17320   160 ALLGLLLLLLVLLFLPETLPEEKRKPL-LSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQ 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 247 -AAAFAGVALFMAFSSFVNARLVGRFGMRKLSHGSLLGFIAITFVWLLVQVLGpePMPFAIFIVFFALAMFQFGWIGSNF 325
Cdd:cd17320   239 fGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLG--GLSLWPLVAPLFLIFFGFGLIFPNA 316

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046555798 326 NSLAMEPLGHVAGTASSVMGFMGTVGGSLIGAAIGQSFDGTALPMVAGFFAVSIVGLIFVLI 387
Cdd:cd17320   317 TSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLIL 378
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 6-384 2.46e-51

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 176.42  E-value: 2.46e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798   6 FIALAAMLMALNALAIDIMLPGLQEIGASLGVENENhRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSA 85
Cdd:TIGR00710   6 FALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASI-VQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  86 IAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHLIFAF 165
Cdd:TIGR00710  85 LGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAF 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 166 MAAIAAVVTAWMYFRLPETLHPddIRPLTASSILGGFKIVLTNRIALCYTLSSTFIFGALFGFINSVEQVYKGIYGLG-A 244
Cdd:TIGR00710 165 LSLAGILLSALIFFILPETLPY--EARIQISTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSpS 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 245 WFAAAFAGVALFMAFSSFVNARLVGRFGMRKLSHgSLLGFIAITFVWLLVQVLGPEPMPFAIFIVFFaLAMFQFGWIGSN 324
Cdd:TIGR00710 243 VFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLR-MGLILFAVSAVLLEITAILGLGSWAMIIGPMM-FVGIGNSMISSI 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 325 FNSLAMEPLGHVAGTASSVMGFMGTVGGSLIGAAIGQSFDGTALPMVAGFFAVSIVGLIF 384
Cdd:TIGR00710 321 AMAYALEDFPHVAGTASALFGTLRLVLGAIVGYLVSLIHGNTAWPMSLSCLVLAVVSVLA 380
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
12-386 6.66e-49

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 169.71  E-value: 6.66e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  12 MLMALnalAIDIMLPGLQEIGASLGVENEnHRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFV 91
Cdd:PRK11102    1 MLMPL---AIDMYLPALPVIAADFGVSAG-SVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  92 PSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHLIFAFMAAIAA 171
Cdd:PRK11102   77 QTIDQLIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 172 VVTAWMYFRLPETLHPDDIRPLTASSILGGFKIVLTNRIALCYTLSSTFIFGALFGFINSVEQVYKGIYGLGAWFAAAFA 251
Cdd:PRK11102  157 LAAALVFFFIPETLPKERRQPFHLRTTIRNFASLFRHKRVLGYMLASGFSFAGMFSFLTAGPFVYIELNGVSPQNFGYYF 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 252 GV-ALFMAFSSFVNARLVGRFG-MRKLSHGSLLGFIAitFVWL-LVQVLGPEPMPFAIFIVFF--ALAMfqfgwIGSNFN 326
Cdd:PRK11102  237 ALnIVFLFVMTIINSRFVRRVGaLNMLRFGLWIQFIM--GIWLvVSALLDLGFWALVVGVAAFvgCVSM-----ISSNAM 309

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 327 SLAMEPLGHVAGTASSVMGFMGTVGGSLIGAAIGQSFDGTALPMVAGFFAVSIVGLIFVL 386
Cdd:PRK11102  310 AVILDEFPHMAGTASSLAGTLRFGIGAIVGALLSLAPFTSAWPMVWSMAFCSILSILFYL 369
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
3-354 1.04e-31

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 123.16  E-value: 1.04e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798   3 RTEFIALAAMLMALNALAIDIMLPGLQEIGASLGVeNENHRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYI 82
Cdd:COG2814     8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGA-SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  83 VSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHLI 162
Cdd:COG2814    87 LGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 163 FAFMAAIAAVVTAWMYFRLPETlhpddiRPLTASSILGGFKIVLTNRIALCYTLSSTFIFGALFGFINSVEQVYKGIYGL 242
Cdd:COG2814   167 FLVNAVLALLALLLLLRLLPES------RPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 243 -GAWFAAAFAGVALFMAFSSFVNARLVGRFGMRKLSHGSLLGFIAITFVWLLVQvlgpepmPFAIFIVFFALAMFQFGWI 321
Cdd:COG2814   241 sASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG-------SLWLLLLALFLLGFGFGLL 313

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1046555798 322 GSNFNSLAMEPLG-HVAGTASSVMGFMGTVGGSL 354
Cdd:COG2814   314 FPLLQALVAELAPpEARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
44-354 9.85e-17

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 80.54  E-value: 9.85e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  44 QYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIY 123
Cdd:pfam07690  35 GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWF 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 124 GGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHLIFAFMAAIAAVVTAWMYFRLPETLHPDDIRPLTASSILGGFK 203
Cdd:pfam07690 115 PPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAW 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 204 IVLTNRIALCYTLSSTFIFGALFGFINSVEQVYKGIYGLGAWFAAAFAGVALFMAFSSFVNARLVGRFGMRKLSHGSLLG 283
Cdd:pfam07690 195 KALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLL 274

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046555798 284 FIAITFVWLLVQVLGpepmPFAIFIVFFALAMFQFGWIGSNFNSLAMEPLG-HVAGTASSVMGFMGTVGGSL 354
Cdd:pfam07690 275 LILAALGLLLLSLTL----SSLWLLLALLLLGFGFGLVFPALNALVSDLAPkEERGTASGLYNTAGSLGGAL 342
 
Name Accession Description Interval E-value
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 7-387 5.47e-93

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 284.08  E-value: 5.47e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798   7 IALAAMLMALNALAIDIMLPGLQEIGASLGVeNENHRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAI 86
Cdd:cd17320     1 LLLLALLVALGPLAIDMYLPALPAIARDLGA-SASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  87 AVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHLIFAFM 166
Cdd:cd17320    80 LCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 167 AAIAAVVTAWMYFRLPETLHPDDIRPLtASSILGGFKIVLTNRIALCYTLSSTFIFGALFGFINSVEQVYKGIYGLGAWF 246
Cdd:cd17320   160 ALLGLLLLLLVLLFLPETLPEEKRKPL-LSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQ 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 247 -AAAFAGVALFMAFSSFVNARLVGRFGMRKLSHGSLLGFIAITFVWLLVQVLGpePMPFAIFIVFFALAMFQFGWIGSNF 325
Cdd:cd17320   239 fGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLG--GLSLWPLVAPLFLIFFGFGLIFPNA 316

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046555798 326 NSLAMEPLGHVAGTASSVMGFMGTVGGSLIGAAIGQSFDGTALPMVAGFFAVSIVGLIFVLI 387
Cdd:cd17320   317 TSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLIL 378
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 6-384 2.46e-51

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 176.42  E-value: 2.46e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798   6 FIALAAMLMALNALAIDIMLPGLQEIGASLGVENENhRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSA 85
Cdd:TIGR00710   6 FALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASI-VQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  86 IAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHLIFAF 165
Cdd:TIGR00710  85 LGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAF 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 166 MAAIAAVVTAWMYFRLPETLHPddIRPLTASSILGGFKIVLTNRIALCYTLSSTFIFGALFGFINSVEQVYKGIYGLG-A 244
Cdd:TIGR00710 165 LSLAGILLSALIFFILPETLPY--EARIQISTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSpS 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 245 WFAAAFAGVALFMAFSSFVNARLVGRFGMRKLSHgSLLGFIAITFVWLLVQVLGPEPMPFAIFIVFFaLAMFQFGWIGSN 324
Cdd:TIGR00710 243 VFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLR-MGLILFAVSAVLLEITAILGLGSWAMIIGPMM-FVGIGNSMISSI 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 325 FNSLAMEPLGHVAGTASSVMGFMGTVGGSLIGAAIGQSFDGTALPMVAGFFAVSIVGLIF 384
Cdd:TIGR00710 321 AMAYALEDFPHVAGTASALFGTLRLVLGAIVGYLVSLIHGNTAWPMSLSCLVLAVVSVLA 380
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
12-386 6.66e-49

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 169.71  E-value: 6.66e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  12 MLMALnalAIDIMLPGLQEIGASLGVENEnHRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFV 91
Cdd:PRK11102    1 MLMPL---AIDMYLPALPVIAADFGVSAG-SVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  92 PSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHLIFAFMAAIAA 171
Cdd:PRK11102   77 QTIDQLIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 172 VVTAWMYFRLPETLHPDDIRPLTASSILGGFKIVLTNRIALCYTLSSTFIFGALFGFINSVEQVYKGIYGLGAWFAAAFA 251
Cdd:PRK11102  157 LAAALVFFFIPETLPKERRQPFHLRTTIRNFASLFRHKRVLGYMLASGFSFAGMFSFLTAGPFVYIELNGVSPQNFGYYF 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 252 GV-ALFMAFSSFVNARLVGRFG-MRKLSHGSLLGFIAitFVWL-LVQVLGPEPMPFAIFIVFF--ALAMfqfgwIGSNFN 326
Cdd:PRK11102  237 ALnIVFLFVMTIINSRFVRRVGaLNMLRFGLWIQFIM--GIWLvVSALLDLGFWALVVGVAAFvgCVSM-----ISSNAM 309

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 327 SLAMEPLGHVAGTASSVMGFMGTVGGSLIGAAIGQSFDGTALPMVAGFFAVSIVGLIFVL 386
Cdd:PRK11102  310 AVILDEFPHMAGTASSLAGTLRFGIGAIVGALLSLAPFTSAWPMVWSMAFCSILSILFYL 369
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
3-354 1.04e-31

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 123.16  E-value: 1.04e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798   3 RTEFIALAAMLMALNALAIDIMLPGLQEIGASLGVeNENHRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYI 82
Cdd:COG2814     8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGA-SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  83 VSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHLI 162
Cdd:COG2814    87 LGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 163 FAFMAAIAAVVTAWMYFRLPETlhpddiRPLTASSILGGFKIVLTNRIALCYTLSSTFIFGALFGFINSVEQVYKGIYGL 242
Cdd:COG2814   167 FLVNAVLALLALLLLLRLLPES------RPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 243 -GAWFAAAFAGVALFMAFSSFVNARLVGRFGMRKLSHGSLLGFIAITFVWLLVQvlgpepmPFAIFIVFFALAMFQFGWI 321
Cdd:COG2814   241 sASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG-------SLWLLLLALFLLGFGFGLL 313

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1046555798 322 GSNFNSLAMEPLG-HVAGTASSVMGFMGTVGGSL 354
Cdd:COG2814   314 FPLLQALVAELAPpEARGRASGLYNSAFFLGGPL 347
emrD PRK11652
multidrug transporter EmrD;
1-217 1.44e-28

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 115.39  E-value: 1.44e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798   1 MGRTEFIALAAMLMALNA---LAIDIMLPGLQEIGASLGVeNENHRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVG 77
Cdd:PRK11652    1 MKRQRNVNLLFMLVLLVAvgqMAQTIYVPAIADMARDLNV-REGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  78 LAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFG 157
Cdd:PRK11652   80 MSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLF 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 158 DWHLIFAFMAAIAAVVTAWMYFRLPETLHPDDIRPltasSILGGFKIVLTNRIALCYTLS 217
Cdd:PRK11652  160 GWRACYLFLLLLGAGVTFSMARWMPETRPADARRT----RVLASYRTLLSNRRFNCYLLM 215
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 7-387 4.83e-22

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 96.46  E-value: 4.83e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798   7 IALAAMLMALNALAIDIMLPglqEIGASLGVEnENHRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAI 86
Cdd:cd17324     4 LALAAFAIGTTEYVIQGLLP---DIARDFGVS-VAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  87 AVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHLIFAFM 166
Cdd:cd17324    80 LAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 167 AAIAAVVTAWMYFRLPETLHpddiRPLTASSILGGFKIVLTNRIALCYTLSSTFIFGALFGFINSVEQVYKGIYGLGAWF 246
Cdd:cd17324   160 AVLALLAALLLWRLLPSLPP----KKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSA 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 247 AAAFAGVA-LFMAFSSFVNARLVGRFGMRKLshgsLLGFIAITFVWLLVQVLGPEPMPFAIFIVFFALAMFqfgWIGSNF 325
Cdd:cd17324   236 IIGLLLLFgVAGVVGSPLAGRLADRGGRRAL----LIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFF---AAHSAL 308

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046555798 326 NSLAMEPLGHVAGTASSVMGFMGTVGGSLIGAAIGQSFDGTALPMVAGFFAVSIVGLIFVLI 387
Cdd:cd17324   309 QTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
46-392 9.73e-20

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 89.94  E-value: 9.73e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  46 VISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGG 125
Cdd:COG2223    45 LFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPP 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 126 RQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHLIFAFMAAIAAVVTAWMYFRLPEtlhPDDIRPLTASSILGGFKIV 205
Cdd:COG2223   125 DRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRD---PPAGAAAAAKASLRDQLEA 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 206 LTNRIALCYTLSSTFIFGALFGFINSVEQVYKGIYGLGAWFAAAFAGVALFM-AFSSFVNARLVGRFGMRKLSHGSLLGF 284
Cdd:COG2223   202 LRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLgALGRPLGGWLSDRIGGRRVLLIVFALM 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 285 IAITFVWLLVqvlgpePMPFAIFIVFFALAMFQFG-WIGSNFNSLAMEPLGHVAGTASSVMGFMGTVGGSLIGAAIGQSF 363
Cdd:COG2223   282 ALGLLLLALA------LGSLWLFLVLFLLLGLALGgGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL 355

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1046555798 364 DGT-----ALPMVAGFFAVSIVGLIFVLIGEKGV 392
Cdd:COG2223   356 DATgsytaAFLVFAVLALVALVLTLLLYRRPRRA 389
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 19-384 1.22e-19

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 89.55  E-value: 1.22e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  19 LAIDIMLPGLQEIGASLGVeNENHRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLL 98
Cdd:cd17474    13 LGVSIVDPILPAIAEALGA-SPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  99 MLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFgDWHLIFAFMAAIAAVVTAWMY 178
Cdd:cd17474    92 AGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLAALIPVAFLAIL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 179 FRLPETLHPDDIRPLTAssiLGGFKIVLTNRIALCYTLSSTFIFGALFGFINSVEQVYKGIYGLGAWF--AAAFAGVALF 256
Cdd:cd17474   171 FLLPEPKEKAKSSSATK---LRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIigLLFAGWSVLL 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 257 MAFSSFVNARLVGRFGMRKLSHGSLLGFiAITFVWLLvqvLGPEPMPFAIFIVFFALAMfqfGWIGSNFNSLAMEPLGHV 336
Cdd:cd17474   248 ALGSLFVGRLLKKRFGARRILVIGLLLY-ALSLLLLG---FVPSLALLLIAIVLFGLGL---GLNLPLLTTLVTELAPEE 320

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1046555798 337 A-GTASSVMGFMGTVGGS---LIGAAIGQSFDGTALPMVAGFFAVSIVGLIF 384
Cdd:cd17474   321 ErGTASSLYNFVRFLGQAvgpLLFGLLLEIFGLSAPFLVGAAIALAAAVLLA 372
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
6-160 1.52e-18

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 86.48  E-value: 1.52e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798   6 FIALAAMLMALNALAIDIMLPGLQEIGASLGVENEnhrqyVISA----YLLGFGIAQLLYGPISDRFGRRKPMFVGLAIY 81
Cdd:PRK11043    7 FLVYLAGLSMLGFLATDMYLPAFKAIQADLQTSAS-----AVSAslslFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLF 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046555798  82 IVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWH 160
Cdd:PRK11043   82 ALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQ 160
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 7-360 1.88e-18

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 86.07  E-value: 1.88e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798   7 IALAAMLMALNALAIDIMLPglqEIGASLGVeNENHRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAI 86
Cdd:cd17321     1 LLLAVFLAALDVTIVNVALP---TIARDLGA-SPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  87 AVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHlifafm 166
Cdd:cd17321    77 LCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWR------ 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 167 aaiaavvtaWMYFrlpetlhpddirpltASSILGGFKIVLTNRIALCyTLSSTFIFGALFGFINSVEQVYKGIYGL-GAW 245
Cdd:cd17321   151 ---------WIFL---------------INVPIGLVALLLARTFSGA-VLAAFLLGAALGGLLFLLPLYLQGVLGYsPLQ 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 246 FAAAFAGVALFMAFSSFVNARLVGRFGMRKLSHGSLLgFIAITFVWLLvqvLGPEPMPFAIFIVFFALAMFQFGWIGSNF 325
Cdd:cd17321   206 AGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLL-LTAVGLLLLA---LLGADSSVWLLLPGLVLLGLGLGLFATPL 281

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1046555798 326 NSLAMEPLG-HVAGTASSVMGFMGTVGGSLIGAAIG 360
Cdd:cd17321   282 TNAALSSVPkEKAGAASGILNTARQLGGALGVALLG 317
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
1-399 3.85e-18

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 85.46  E-value: 3.85e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798   1 MGRteFIALAAMLMALNALAIDIMLPGLQEIGASLGVeNENHRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAI 80
Cdd:PRK10473    1 MSR--FLLCSFALVLLYPAGIDMYLVGLPRIAADLNA-SEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAAL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  81 YIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWH 160
Cdd:PRK10473   78 FIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 161 LIFAFMAAIAAVVTAWMYFRLPETLhpdDIRPLTASSILGGFKIVLTNRIALCYTLSSTFIFGALFGFINSVEQVYKGIY 240
Cdd:PRK10473  158 SLFYTMAAMGILVLLLSLFILKETR---PARAPAASSKPRENSESLLNRFFLSRLVITTLSVTVILTFVNTSPVLLMEQM 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 241 GLGAWFAAAFAGVALFMAFS-SFVNARLVGRFGMRKLSHGSLLGFIAITFVWLLVQVLGPEPMPFAI----FIVFFALAM 315
Cdd:PRK10473  235 GFSRGEYAIIMALTAGVSMTvSFSTPFALGIFKPRTLMLTSQVLFLAAGITLALSPSHAVSLFGITLicagFSVGFGVAM 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 316 FQfgwigsnfnslAMEPLGHVAGTASSVMGFMGTVGGSL---IGAAIGQSfdgtALPMVAG-FFAVSIVGLIFVLIGEKG 391
Cdd:PRK10473  315 SQ-----------ALGPFSLRAGVASSTLGIAQVCGSSLwiwLAAVLGIS----AWNMLIGiLIACSIVSLLLILFVAPG 379


                  ....*...
gi 1046555798 392 VLFQAHNK 399
Cdd:PRK10473  380 RPVAAHEE 387
2_A_01_02 TIGR00880
Multidrug resistance protein;
48-184 5.60e-17

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 76.92  E-value: 5.60e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  48 SAYLLGFGIAQLLYGPIS----DRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIY 123
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSglltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046555798 124 GGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHLIFAFMAAIAAVVTAWMYFRLPET 184
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 45-388 9.34e-17

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 81.08  E-value: 9.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  45 YVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYG 124
Cdd:cd17325    35 LIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAP 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 125 GRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHLIFAFMAAIAAVVTAWMYFRLPETLHPDDIRPLTASSILGGFKI 204
Cdd:cd17325   115 PEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRL 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 205 VLTNRiALCYTLSSTFIFGALFGFINSVEQVY-KGIYGLGAWFA-AAFAGVALFMAFSSFVNARLVGRFGMRKLSHGSLL 282
Cdd:cd17325   195 LLRDR-RLLALFLAIFVLAFAFGALEPFLPLYaAELGGLSPAQIgLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLL 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 283 GFIAITFVWLLVQvlgpepmPFAIFIVFFALAMFQFGWIGSNFNSLAM-----EPLGHVAGTASSVMGFmGTVGGSLIGA 357
Cdd:cd17325   274 LSAVALLLLPLAT-------SFWLLLLLLALLGLGLGLVFPATLALLAdivppEGRGTAMGLFNTAFSL-GMVLGPLLGG 345

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1046555798 358 AIGQSFdGTALPMVAGfFAVSIVGLIFVLIG 388
Cdd:cd17325   346 FLYDAF-GFATPFLAA-AALLLLAAVLFLLL 374
MFS_1 pfam07690
Major Facilitator Superfamily;
44-354 9.85e-17

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 80.54  E-value: 9.85e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  44 QYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIY 123
Cdd:pfam07690  35 GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWF 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 124 GGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHLIFAFMAAIAAVVTAWMYFRLPETLHPDDIRPLTASSILGGFK 203
Cdd:pfam07690 115 PPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAW 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 204 IVLTNRIALCYTLSSTFIFGALFGFINSVEQVYKGIYGLGAWFAAAFAGVALFMAFSSFVNARLVGRFGMRKLSHGSLLG 283
Cdd:pfam07690 195 KALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLL 274

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046555798 284 FIAITFVWLLVQVLGpepmPFAIFIVFFALAMFQFGWIGSNFNSLAMEPLG-HVAGTASSVMGFMGTVGGSL 354
Cdd:pfam07690 275 LILAALGLLLLSLTL----SSLWLLLALLLLGFGFGLVFPALNALVSDLAPkEERGTASGLYNTAGSLGGAL 342
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
45-387 1.59e-15

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 77.22  E-value: 1.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  45 YVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYG 124
Cdd:COG2271    49 LLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFP 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 125 GRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHlifafmaaiaavvtaWMYFrlpetlhpddirpltASSILGGFKI 204
Cdd:COG2271   129 PKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWR---------------AAFL---------------ILGLPGLLLA 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 205 VLTNRIALCYTLSSTFIFGALFGFINSVEQVYKGIygLGAWFAAAFAGVALFMAFSSFVNARLVGRFGMRKLSHGSLLGF 284
Cdd:COG2271   179 LLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGL--SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLL 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 285 IAITFVWLLVQVLGPepmpfAIFIVFFALAMFQFGWIGSNFNSLAMEPLG-HVAGTASSVMGFMGTVGGSLIGAAIGQSF 363
Cdd:COG2271   257 LAALALLLLALLPSP-----ALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGALGPLLVGYLL 331

                         330       340
                  ....*....|....*....|....
gi 1046555798 364 DGTALPMVAGFFAVSIVGLIFVLI 387
Cdd:COG2271   332 DATGYQAAFLLLAALALLAALLAL 355
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 7-288 2.30e-15

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 76.00  E-value: 2.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798   7 IALAAMLMALNALAIDIMLPGLQEIGASLGVeNENHRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAI 86
Cdd:COG0477    16 LLALALGTFLEGLDFTIVNVALPSIAADLGA-SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  87 AVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHLiFAFM 166
Cdd:COG0477    95 LCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRW-IFLI 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 167 AAIAAVVTAWMYFRLPETLHPDDIRPLTASSILGGFKIVLTNRIALCYTLSSTFIFGALFGFINSVEQVYKGIYGLGAWF 246
Cdd:COG0477   174 NAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLL 253

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1046555798 247 AAAFAGVALFMAFSSFVNARLVGRFGMRKLSHGSLLGFIAIT 288
Cdd:COG0477   254 LALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 7-363 1.02e-14

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 74.92  E-value: 1.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798   7 IALAAMLMALNALAIDIMLPglqEIGASLGVeNENHRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAI 86
Cdd:cd17503     1 LLLGAFMAILDTTIVNVALP---TIMGDLGA-SLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  87 AVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHlifafm 166
Cdd:cd17503    77 LCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWR------ 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 167 aaiaavvtaWMYFRlpetlhpddIRPLTASSILGGFKI---VLTNRIALCYTLSSTFIFGALFGFINSVEQVYKGIYGLG 243
Cdd:cd17503   151 ---------WIFYI---------NLPIGILALLLAPLLdlrLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYS 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 244 AWFA-AAFAGVALFMAFSSFVNARLVGRFGMRKLshgSLLGFIAITFVWLLVQVLGPEpMPFAIFIVFFALAMFQFGWIG 322
Cdd:cd17503   213 AFESgLVLAPGGLASAILSPLVGRLLDKFGPRLL---LLAGLLLLALGTLLLAFLTPD-TSLWLIILPLFIRGLGMGLVF 288

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1046555798 323 SNFNSLAMEPL-GHVAGTASSVMGFMGTVGGSlIGAAIGQSF 363
Cdd:cd17503   289 MPLNTLALNSLpPEQIGDATALFNTIRQLGGS-IGTALLATL 329
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
19-229 1.53e-14

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 74.59  E-value: 1.53e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  19 LAIDIMLPGLQEIGASLGVENEnHRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLL 98
Cdd:PRK15402   27 IANDMIQPGMLAVVEDFNAGAE-WVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFT 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  99 MLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHLIFAFMAAIAAVVTAWMY 178
Cdd:PRK15402  106 LLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLW 185

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1046555798 179 FRLPETLHpDDIRPLTASSILGGFKIVLTNRIALCYTLSSTFIFGALFGFI 229
Cdd:PRK15402  186 RAMPETAG-RVGEKLSLKELGRDYKLVLKNRRFVAGALALGLVSLPLLAWI 235
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
47-212 9.28e-14

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 72.17  E-value: 9.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  47 ISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGR 126
Cdd:PRK15403   57 VSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQT 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 127 QMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHLIFAFMAAIAAVVTAWMYFRLPETLHPDDiRPLTASSILGGFKIVL 206
Cdd:PRK15403  137 KGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVKRGA-VPFSAKSVLRDFRNVF 215


                  ....*.
gi 1046555798 207 TNRIAL 212
Cdd:PRK15403  216 RNRLFL 221
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 10-386 5.70e-13

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 69.76  E-value: 5.70e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  10 AAMLMALNALAIDIMLPGLQEIGASLGVENENHRqYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVV 89
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLG-LLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  90 FVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVL--FFGDWHLIFAFMA 167
Cdd:cd06174    80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 168 AIAAVVTAWMYFRLPETLHPDDIRPLTAS--SILGGFKIVLTNRIALCYTLSSTFIFGALFGFINSVEQVYKGIYGLGAW 245
Cdd:cd06174   160 ALALLAAILLLLVVPDPPESARAKNEEASskSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 246 FAAAFAGVALFM-AFSSFVNARLVGRFGMRKLSHGSLLGFIAITFVWLLVQVLGPEPMPFAIFIVFFAlamfqFGWIGSN 324
Cdd:cd06174   240 VAGLLLSLFGLAgALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGL-----GGLLPLS 314

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046555798 325 FNSLAMEPLGHVAGTASSVMGFMGTVGGSLIGAAIGQSFDGTALPMVAGFFAVSIVGLIFVL 386
Cdd:cd06174   315 FALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 47-241 2.15e-12

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 67.99  E-value: 2.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  47 ISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGR 126
Cdd:cd17323    40 VSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPE 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 127 QMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHlifafmaaiaavvtaWMYFRLpetlhpddirpltasSILGGFK--- 203
Cdd:cd17323   120 ERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWR---------------WIFWFL---------------AIISGFClil 169

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1046555798 204 IVLTNRIALCYTLSSTFIFGALFGFINSVEQVYKGIYG 241
Cdd:cd17323   170 IFLFLPIVLLLGLYVGLVYAILYLFLTAFPYVFGEVYG 207
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
7-391 2.66e-12

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 67.57  E-value: 2.66e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798   7 IALAAMLMALNALAIDIMLPGLQEIGASLGVeNENHRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAI 86
Cdd:COG0738    10 LIAIYLLFFLWGFATALWGPLIPALKDAFGL-SDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  87 AVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAeVMSLIMMVFMVVPVIAPGTGQIVLFFG---DWHLIF 163
Cdd:COG0738    89 LFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAAS-RLNLLHAFFSLGALLGPLLGGLLILLGlslSWHLPY 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 164 AFMAAIAAVVTAWMYF-RLPETLHPDDIRPLTASSILGGFKivltNRIALCYTLSSTFIFGALFGFINSVEQVYKGIYGL 242
Cdd:COG0738   168 LILAVLLLLLALLFLRsKLPEIEEEEEEAAGSAASLKSLLK----NPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 243 -GAWFAAAFAGVALFMAFSSFVNARLVGRFGMRKLshgsLLGFIAITFVWLLVQVLGPEPMPFAIFIVFFALAMfqfGWI 321
Cdd:COG0738   244 sEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRL----LRLSALLAAVGLLLALLAPGPWLALIGLALVGLGL---SLM 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 322 GSNFNSLAMEPLGHVAGTASSVMGFMGTVGGSLIGAAIGQSFDGTALpmVAGFFAVSIVGLIFVLIGEKG 391
Cdd:COG0738   317 FPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGL--RAAFLVPLVCYLLILLLALAL 384
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 45-376 6.50e-10

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 59.88  E-value: 6.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  45 YVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYG 124
Cdd:cd17502    34 WVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVP 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 125 GRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHLIfafmaaiaavvtawMYFRLPetlhpddirpltassiLGGFKI 204
Cdd:cd17502   114 PRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWC--------------FYINLP----------------IGGLAL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 205 VLTNRIALCYTLSStFIFGALFGFINSVEQVYKGIYGLGAWFA-AAFAGVALFMAFSSFVNARLVGRFGMRKLShgSLLG 283
Cdd:cd17502   164 ALLRTILLSSIFGF-LFGGALFGLIYYLPLYFQLVLGDSATKSgVRLLPLIIGLVIGSIISGALISKTGRYKPL--IVIG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 284 FIAITFVWLLVQVLGPEpMPFAIFIVFFALAMFQFGWIGSNFNSLAMEPLGH-VAGTASSVMGFMGTVGGSlIGAAIGQS 362
Cdd:cd17502   241 TILMSVGAGLLTTLTLD-TSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPaDVGVATATNTFFRSLGGT-LGVAITDV 318

                         330
                  ....*....|....
gi 1046555798 363 FDGTALPMVAGFFA 376
Cdd:cd17502   319 FLVALALAALAFLL 332
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 38-159 3.77e-09

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 57.59  E-value: 3.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  38 ENENHRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVS 117
Cdd:cd17317    22 DRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFV 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1046555798 118 IVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGtgqIVLFFGDW 159
Cdd:cd17317   102 LGMEIVGPKYRSFVGILFGLFWALGYMLLAL---LAYLIRDW 140
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 14-148 1.10e-08

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 56.95  E-value: 1.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  14 MALNALAIDIMLPGLQEIGASLGVE------NENHRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIA 87
Cdd:TIGR00898  94 LAATEPCLDGWEYSYDTFSSTIVTEwdlvceDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVL 173

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046555798  88 VVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPG 148
Cdd:TIGR00898 174 TAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPL 234
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 45-387 1.22e-08

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 56.07  E-value: 1.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  45 YVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYG 124
Cdd:cd17316    40 LLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAP 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 125 GRQMAEVMSLIMMVFMVVPVIApgtgqivlffgdwhlifafmaaiaavvTAWMYFRLPETLHPDDIRPLTASSILGGFKI 204
Cdd:cd17316   120 SKRRGFALGLLQSGWALGALLA---------------------------ALVASLLIPLLSGDWGWRILFLIGALPALLA 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 205 VLTNRIALCYTLSSTFIFGALFGFINSVEQVYKGIYGL-GAWFAAAFAGVALFMAFSSFVNARLVGRFGMRKLSHGSLLG 283
Cdd:cd17316   173 LLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLsPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLIL 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 284 FIAITFVWLLVqvlgPEPMPFAIFIVFFALAMFQFGWIGSNFNSLAMEPLGHVAGTASSVMGFMGTVGGSLIGAAIGQSF 363
Cdd:cd17316   253 SGILALPLFYL----LSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLL 328

                         330       340
                  ....*....|....*....|....
gi 1046555798 364 DGTALPMVAGFFAVSIVGLIFVLI 387
Cdd:cd17316   329 ASTGGTGVPALILALLAIVALIVA 352
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 6-388 3.91e-08

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 54.89  E-value: 3.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798   6 FIALAAMLMAlnalaiDIMLPGLQEIGASLGVeNENHRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSA 85
Cdd:cd17504     3 LAALAVMLVE------TMLSPALPTIQREFGT-SAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  86 IAVVFVPSFSGLLMLRFIQGIGSAATRvITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHLIFAF 165
Cdd:cd17504    76 LLAAFAPNLPVLIAGRALQGIGGAVFP-LAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWT 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 166 MAAIAAVVTAwmyfrlpetlhpddIRPLTASSILGGFKIVLTNRIALcytLSSTFIFGALFGFINSVEQVYKGIYGLGAW 245
Cdd:cd17504   155 AAPVAVLLAA--------------LVPLIDLRLLRRRNVLLANITAL---LAGFGMFMVFQLLPQLLQLPTPTGFGLGIT 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 246 FAAAFAG-VALFMAFSSFVNARLVGRFGMRKLSHGSLLgFIAITFVWLLVQVLGPEPMPFAIFIVFFALAMFQFGWIGSN 324
Cdd:cd17504   218 EAGLLLLpGALVMLIAGPLAGRLIARVGPRRVLLIGLV-ISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIV 296

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1046555798 325 FNSLAMEPLGHVAGTaSSVMGFMGTVGGSLIGAAIGQSFDGTALPMV----AGFFAVSIVGLIFVLIG 388
Cdd:cd17504   297 VESVPPDRTGIATGM-NTVLRTIGSAIGPAIAGAILTTYTVSITSGGvpteGAYVLAFLIGAALALAA 363
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 46-150 4.25e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 54.52  E-value: 4.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  46 VISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGG 125
Cdd:cd17489    36 VVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPP 115

                          90       100
                  ....*....|....*....|....*
gi 1046555798 126 RQMAEVMSLIMMVFMVVPVIAPGTG 150
Cdd:cd17489   116 SRRGEGIGYYGLATTLAMALGPALG 140
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 52-148 9.06e-08

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 53.51  E-value: 9.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  52 LGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEV 131
Cdd:cd17379    44 LGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTV 123

                          90
                  ....*....|....*..
gi 1046555798 132 MSLIMMVFMVVPVIAPG 148
Cdd:cd17379   124 GIVYQMFFTLGLLILPG 140
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 15-138 1.44e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 52.96  E-value: 1.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  15 ALNALAIDIMLPGLQEIGASLGVENENHRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSF 94
Cdd:cd17473     9 TLTVMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSL 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1046555798  95 SGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMV 138
Cdd:cd17473    89 YALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAA 132
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 3-150 5.43e-07

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 51.61  E-value: 5.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798   3 RTEFIALAAMLMA-LNALAIDIMLPGLQ-EIGASLGVenenhRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAI 80
Cdd:TIGR00711   2 LLTIVLMLGTFMAvLDSTIVNVAIPTIAgDLGSSLSQ-----VQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFA 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  81 YIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTG 150
Cdd:TIGR00711  77 FTLGSLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLG 146
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 46-383 5.57e-07

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 51.02  E-value: 5.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  46 VISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGG 125
Cdd:cd17477    36 VASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATN 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 126 RQMAEVMSLIMMVFMvvpvIAPGTGQIVLFFGDWHLIFAFMAAIAAVVTAWmyfrLPETLHPDDIRPLTASSILGGFKIV 205
Cdd:cd17477   116 ENRGRVLGLYSTVLG----LGFALGPLLLALVGTAGALPFLIAAVLLLLAL----VPLLLTRRAAPEIEEAESISLRRLL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 206 LTNRIALCYTLSSTFIFGALFGFInsveqvykGIYGLGA-WFAAAFAGVALFMAFSSFVNARLVGRFGMRKLSHGSLLGF 284
Cdd:cd17477   188 RIAPLALLGAFVAGFLEGAFYSLL--------PLYGLRLgLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGC 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 285 IAITFVWLLVQVLGPePMPFAIFIVFFALAMFQFGwigsnFNSLAMEPLGHVAG-----TASSVMGFM---GTVGGSLIG 356
Cdd:cd17477   260 ALLGALAALLLPLVP-GLPLALLVLLFLWGGAAGP-----LYTLALALAGDRLPgdelvAANAALLLLyglGSVIGPLLA 333

                         330       340
                  ....*....|....*....|....*..
gi 1046555798 357 AAIGQSFDGTALPMVAGFFAVSIVGLI 383
Cdd:cd17477   334 GALMDAFGPHGLFLFLAAVALLFLLFL 360
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 56-123 7.94e-07

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 50.65  E-value: 7.94e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1046555798  56 IAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIY 123
Cdd:cd17384    46 ITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVAGMGMLASLY 113
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 44-161 1.01e-06

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 50.37  E-value: 1.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  44 QYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIY 123
Cdd:cd17374    38 SVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWT 117

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1046555798 124 GGRQMAEVMSLIMMVFMVVPVIAPGtgqIVLFFGDWHL 161
Cdd:cd17374   118 TPRHRALAITLTSCFFSIGQMLLAG---LAYAIRDWRL 152
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 6-147 1.36e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 49.88  E-value: 1.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798   6 FIALAAMLMALNALAIDIMLPGLQEIGASLGVENENHRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSA 85
Cdd:cd17325   200 RLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046555798  86 IAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAP 147
Cdd:cd17325   280 LLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGP 341
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 46-386 3.12e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 48.77  E-value: 3.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  46 VISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSG-----LLMLRFIQGIGSAATRVITVSIVR 120
Cdd:cd06173    39 VLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSlslwlLLVLAFLLGIASAFFGPARQALLP 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 121 DIYGGRQMAEVMSLIMMVFMVVPVIAPG-TGQIVLFFGDWHLIFAFMAAIAAVVTAWMYFRLPETLHPDDIRPLTASSIL 199
Cdd:cd06173   119 ELVPKEQLVRANALNSLATQLARIIGPAlGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLR 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 200 GGFKIVLTNRIalcytLSSTFIFGALFGFINSVEQVYKGIYGLGAWFAAAFAGVALFMAFS--SFVNARLVGRFGMRKLS 277
Cdd:cd06173   199 EGLRYLRRSPL-----LRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGvgALLGALLLGRLSKRRRR 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 278 HGSLLGFIAITFVWLLVQVLGPepmPFAIFIVFFALAMFQFGWIGSNFNSLAM-----EPLGHVAGTASSVMGFMgTVGG 352
Cdd:cd06173   274 GRLLLIGALLLGLALLVLGLSP---SLWLLLAALFLLGLAGGLFNVPLNTLLQlrvpdELRGRVFSVYNALNSGA-MPLG 349

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1046555798 353 SLIGAAIGQSFDGTALPMVAGFFAVSIVGLIFVL 386
Cdd:cd06173   350 ALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 46-107 4.40e-06

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 48.33  E-value: 4.40e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046555798  46 VISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIG 107
Cdd:cd17359    41 VVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLA 102
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 10-157 1.08e-05

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 47.26  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  10 AAMLMALNALAIDIMLPGLQEIGASLGVeNENHRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVV 89
Cdd:cd17476     3 ISGAQLLNQAGLGSVIVILPIIGDSFGT-SPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAG 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1046555798  90 FVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEvmslimMVFMVVPVIAPGTGQIVLFFG 157
Cdd:cd17476    82 FSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKN------IVFSLFGATAPLGFALGGVFG 143
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 45-387 1.46e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 46.79  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  45 YVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYG 124
Cdd:cd17319    42 LIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFP 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 125 GRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHLIFAFMAAIAAVVTAWMYFRLPETLhPDDIRPLTASSILGGFKI 204
Cdd:cd17319   122 ARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQVW-GLALGYFGINYALYGLLT 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 205 VLTNRIALCYTLSSTFIfgalfGFINSVEQVykgiyglgawfaaafagvalFMAFSSFVNARLVGRFGMRKLSHGSLLGF 284
Cdd:cd17319   201 WLPTYLKQARGFSLKQV-----GLLAAIPFL--------------------AGAIGMILGGRLSDRLLRGARRLVIIIGL 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 285 IAITFVWLLVQVLGPEPMPfaifIVFFALAMFQFGWIGSNFNSLAMEPL-GHVAGTASSVMGFMGTVGGSLIGAAIGQSF 363
Cdd:cd17319   256 LLAAVGLLLAYLTTSPVVA----VILLSLAGFGIGAASPVFWSLPADLLpGEAAATAGGLINSGGNLGGFVAPLLIGYLV 331

                         330       340
                  ....*....|....*....|....
gi 1046555798 364 DGTALPMvAGFFAVSIVGLIFVLI 387
Cdd:cd17319   332 DATGSYT-AAFLFLAAVALLAALL 354
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 13-380 1.50e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 46.42  E-value: 1.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  13 LMALNALAIDIMLPGLQEIGASLGVENENHRQ--YVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVF 90
Cdd:cd17330     4 VVFLDALGFGIVFPVLPFYVREFNKLGASGYYvgLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  91 VPSFSGLLMLRFIQGIGSAATRVITvSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGqivlffgdwhlifafmaaia 170
Cdd:cd17330    84 SRNLWLLFLARFLDGLTGGNVSVAQ-AYIADITDEEERAKAFGIISAAFGLGFILGPALG-------------------- 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 171 avvtAWMYFRLPETLhpddirPLTASSILGGFKIVLTNRI--ALCYTLSSTFIFGALFGFINSVEQVY---KGIYGLGAW 245
Cdd:cd17330   143 ----GFLSTPYGYAL------PFLVAAALALLNLVLVLFFlpPLRRLLLVYFLIALAFAGLESVFSLFlkdRFGFSPSQI 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 246 FAAAFAGVALFMAFSSFVNARLVGRFGMRKLSHGSLlgFIAITFVWLLVQVLGPEPMPFAIFIVFFALAMFQFGWIGSNF 325
Cdd:cd17330   213 GLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGL--LLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLS 290

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1046555798 326 NSLAMEPLGHVAGTASSVMGFMGTVGGSLIGAAIGQSFDGTALPMVAGFFAVSIV 380
Cdd:cd17330   291 KSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALF 345
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 46-136 2.21e-05

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 46.04  E-value: 2.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  46 VISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGG 125
Cdd:cd17365    39 VGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPA 118

                          90
                  ....*....|.
gi 1046555798 126 RQMAEVMSLIM 136
Cdd:cd17365   119 RRRSLAVTLMF 129
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
6-161 2.42e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 46.02  E-value: 2.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798   6 FIALAAMLMALNA-LAIDIMLPGLQEIGASLGVeneNHRQ--YVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYI 82
Cdd:COG2807    18 LLLLAIVLVALNLrPAITSVGPLLPEIRADLGL---SATQagLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLA 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046555798  83 VSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDiYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHL 161
Cdd:COG2807    95 AGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKR-WFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRG 172
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 48-141 2.72e-05

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 45.92  E-value: 2.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  48 SAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQ 127
Cdd:cd17377    46 SFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAFVLLNECVGKSY 125

                          90
                  ....*....|....
gi 1046555798 128 MAEVMSLIMMVFMV 141
Cdd:cd17377   126 WALAGSLGGLFFAV 139
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
56-360 3.72e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 45.66  E-value: 3.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  56 IAQLLYGPISD----RFGRRKP-MFVGLAIYIVSAIAVVFVPSFSG----------LLMLRFIQGIGSAATRVITVSIVR 120
Cdd:COG2211    61 ITDPLIGALSDrtrtRWGRRRPwILIGAIPLALSFVLLFTAPDLSPtgkliyalvtYLLLGLAYTLVNIPYSALGAELTP 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 121 DiygGRQMAEVMSLIMMVFMVVPVIAP-GTGQIVLFFGD-----WHLIFAFMAAIAAVVTAWMYFRLPETLHPDDirplT 194
Cdd:COG2211   141 D---YEERTRLSSWRFAFAGLGGLLASvLPPPLVAAFGGdaalgYRLTALIFAVLGLLAFLLTFFGTKERPVPEE----E 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 195 ASSILGGFKIVLTNR-------IALCYTLSSTFIFGALFGFINSVEQVYKGIYGLGAWFAAAFagvalfMAFSSFVNARL 267
Cdd:COG2211   214 KVSLKESLKALLKNRpflllllAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLA------ALLGAPLWPRL 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 268 VGRFGMRKLSHGSLLGFIAITFVWLLVQvlgpepmPFAIFIVFFALAMFQFGWIGSNFNSLAM----------EPLGHVA 337
Cdd:COG2211   288 AKRFGKKKAFIIGLLLAALGLLLLFFLG-------PGNLWLLLVLAALAGIGLGAILVLPWAMladvvdydewKTGRRRE 360

                         330       340
                  ....*....|....*....|...
gi 1046555798 338 GTASSVMGFMGTVGGSLIGAAIG 360
Cdd:COG2211   361 GLYFGIFTFAIKLGQALAGALAG 383
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 48-134 1.04e-04

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 44.15  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  48 SAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQ 127
Cdd:cd17328    41 TVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEK 120


                  ....*..
gi 1046555798 128 MAEVMSL 134
Cdd:cd17328   121 RTRALGV 127
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 51-141 1.63e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 43.44  E-value: 1.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  51 LLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAE 130
Cdd:cd17371    44 LAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGK 123

                          90
                  ....*....|.
gi 1046555798 131 VMSLIMMVFMV 141
Cdd:cd17371   124 ALGYVQSGWAV 134
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 52-146 1.86e-04

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 43.48  E-value: 1.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  52 LGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEV 131
Cdd:cd17439    45 LGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEH 124

                          90
                  ....*....|....*
gi 1046555798 132 MSLIMMVFMVVPVIA 146
Cdd:cd17439   125 LSWLCMFWMIGGIYA 139
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 7-107 2.06e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 43.11  E-value: 2.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798   7 IALAAMLMALNALAIDIMLPGLQEIGASLGVENENHrQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAI 86
Cdd:TIGR00895  19 IILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQL-GFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTL 97

                          90       100
                  ....*....|....*....|.
gi 1046555798  87 AVVFVPSFSGLLMLRFIQGIG 107
Cdd:TIGR00895  98 LCALATNVTQLLILRFLAGLG 118
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 2-146 2.08e-04

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 43.43  E-value: 2.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798   2 GRTEFIALAAMLMALNALAIDIMLPG--LQEIGASLGVENENhRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLA 79
Cdd:TIGR01299 162 GRFQWALFFVLGLALMADGVEVFVVGfvLPSAEKDLCIPDSG-KGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLS 240

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1046555798  80 IYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIA 146
Cdd:TIGR01299 241 VNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYA 307
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 56-383 2.33e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 42.98  E-value: 2.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  56 IAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLI 135
Cdd:cd17329    50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLL 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 136 MMVFMVVPVIAPGTGqIVLFFGDWHLIFAFMAAIAAVVTAWMYFRLPETLHPDdiRPLTASSILGGFKIVLTNRIALCYT 215
Cdd:cd17329   130 YWAINLGVAIGPLLG-GLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKR--RAAEKTEILRGYKIVLRDRAFLLFL 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 216 LSSTFIFGALFGFINSVEQVYKGIYGLGAWFAAAFAGVALFMAF-SSFVNARLVGRFGMRKLSHGSLLGFIaitfVWLLV 294
Cdd:cd17329   207 LASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVlLQFPVARLVERFRLRKILMIGILLFA----IGFAV 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 295 QVLGPEPMPFAIFIVFFALA-MFQFGWIGSNFNSLAMEP-LGHVAGTASSVMGFMGTVGGSLIGAAIGQSFDGTALPMVA 372
Cdd:cd17329   283 LAFANTLAVLILAMIVLTLGeMLVFPAVQTLVAALAPPDkRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILA 362

                         330
                  ....*....|.
gi 1046555798 373 GFFAVSIVGLI 383
Cdd:cd17329   363 ALGLIAAALLL 373
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 45-360 2.70e-04

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 42.75  E-value: 2.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  45 YVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYG 124
Cdd:TIGR00881  34 LLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 125 GRQMAEVMSLIMMVFMVVPVIAPGT-GQIVLFFGDWHLIFAFMAAIAAVVT---AWMY--------------FRLPETLH 186
Cdd:TIGR00881 114 RSERGTWVSFWNCSHNVGGGLLPPLvLFGIAELYSWHWVFIVPGIIAIIVSlicFLLLrdspqscglppaeeMPNEEPDG 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 187 PDDIRPLTASSILGGFKIVLTNRIALCYTLSSTFIFGALFGFINSVEQVYKGIYGLGAWFAAAFAGVALFMAFSSFVNAR 266
Cdd:TIGR00881 194 DAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAG 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 267 LVGRFGMRKLSHGSLLGFIAITFVWLLVQVLGPEPMPFAIFIVFFALAMFQFGWIgSNFNSLAMEpLGH--VAGTASSVM 344
Cdd:TIGR00881 274 WLSDKLFNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPQ-MLIGVIASE-LAPkkAAGTAAGFV 351

                         330
                  ....*....|....*.
gi 1046555798 345 GFMGTVGGSLIGAAIG 360
Cdd:TIGR00881 352 GFFAYLGGILAGLPLG 367
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 43-119 3.80e-04

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 42.02  E-value: 3.80e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1046555798  43 RQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIV 119
Cdd:cd17446    35 RQLAQSIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLN 111
PRK10504 PRK10504
putative transporter; Provisional
 16-160 4.15e-04

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 42.41  E-value: 4.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  16 LNALAIDIMLPGLQEIGASLGvENENHRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFS 95
Cdd:PRK10504   21 MQSLDTTIVNTALPSMAQSLG-ESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLN 99

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1046555798  96 GLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWH 160
Cdd:PRK10504  100 ELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWH 164
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 46-377 4.35e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 42.16  E-value: 4.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  46 VISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGG 125
Cdd:cd17478    36 LVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAAGG 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 126 RQmaevmSLIMMVFMVV--------PVIApgtgqIVLFFGDWHLIFAFMAAIAAVVTAWMYFRLPETLHPddIRPLTASS 197
Cdd:cd17478   116 RR-----GLAMSIFSVGgnlgfalgPLIA-----AALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKP--EAKKAAAK 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 198 ILGGFKIVLTNRIALCYTLSSTFIFGALFGFINSVEQVYKGIYGLGAWFAAAFAGVALFMAFSSFVNARLVGRFGMRKLS 277
Cdd:cd17478   184 SSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVI 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 278 HGSLLGfiAITFVWLLVQVLGPEPMPFAIFIVFFALAMFqfgwigSNFNSLAMEPLGHVAGTASSVMGFMGTVGGSLIGA 357
Cdd:cd17478   264 IASLLL--AAPFLLLFLLTPGIWSYILLVLAGFLLFASF------PVTVVLAQELLPGNVGLASGLMMGLSFGLGGIGAP 335

                         330       340
                  ....*....|....*....|
gi 1046555798 358 AIGQSFDGTALPMVAGFFAV 377
Cdd:cd17478   336 VLGALADAFGLESVLLILAL 355
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 50-109 4.45e-04

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 42.07  E-value: 4.45e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  50 YLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSA 109
Cdd:cd17445    45 FILGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAASPSLFMAMRFLLGAALA 104
MFS_YdiM_like cd17396
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ...
 45-110 5.10e-04

Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340954 [Multi-domain]  Cd Length: 384  Bit Score: 41.95  E-value: 5.10e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1046555798  45 YVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAA 110
Cdd:cd17396    39 YVISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFVGILFSPNLIIAYVFALLAGAANSF 104
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 31-107 5.70e-04

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 41.79  E-value: 5.70e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1046555798  31 IGASLGVENENHRQ-YVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIG 107
Cdd:cd17315    23 IAKDLGFGLSTSLQgLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLG 100
Sugar_tr pfam00083
Sugar (and other) transporter;
46-107 6.14e-04

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 41.87  E-value: 6.14e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1046555798  46 VISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLML---RFIQGIG 107
Cdd:pfam00083  51 IVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLivgRVLVGIG 115
MFS_SLC18A3_VAChT cd17383
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ...
 56-109 8.47e-04

Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340941 [Multi-domain]  Cd Length: 378  Bit Score: 41.14  E-value: 8.47e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1046555798  56 IAQLLYGPIS----DRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSA 109
Cdd:cd17383    41 IVQLLVNPFSgtliDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFFARSLQGVGSA 98
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 54-116 1.85e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 40.28  E-value: 1.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1046555798  54 FGIAQLLY----GPISDRFGRRKP-MFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITV 116
Cdd:cd17490    40 YGISQMLLriplGILSDRIGKRKLfIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTV 107
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
45-184 2.35e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 39.85  E-value: 2.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  45 YVISAYLLGFGIAQLLYGPISDRFGRRK--PMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDI 122
Cdd:COG2271   220 LLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAEL 299

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046555798 123 YGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVLFFGDWHLIFAFMAAIAAVVTAWMYFRLPET 184
Cdd:COG2271   300 FPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRET 361
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 45-147 2.89e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.46  E-value: 2.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  45 YVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLM-LRFIQGIGSAATRVITVSIVRDIY 123
Cdd:cd17477   227 LLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLvLLFLWGGAAGPLYTLALALAGDRL 306

                          90       100
                  ....*....|....*....|....
gi 1046555798 124 GGRQMAEVMSLIMMVFMVVPVIAP 147
Cdd:cd17477   307 PGDELVAANAALLLLYGLGSVIGP 330
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 47-147 3.15e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 39.51  E-value: 3.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  47 ISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVIT--VSIVRDIYG 124
Cdd:cd17472    38 LGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAISSVVMAllADLTREENR 117

                          90       100
                  ....*....|....*....|...
gi 1046555798 125 GRQMAEVMSLIMMVFMVVPVIAP 147
Cdd:cd17472   118 TKAMALIGASIGIAFAISMVLGP 140
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 12-386 3.44e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 39.23  E-value: 3.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  12 MLMALNALAIDIMLPGLQEIGASlgveNENHRQYVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFV 91
Cdd:cd17333     6 FSNGLTDALLGILGPSLEEAFNL----NVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFAT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  92 PSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQmAEVMSLIMMVFMVVPVIAPGTGQ-IVLFFGDWHLI-FAFMAAI 169
Cdd:cd17333    82 PSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESS-ATRLNVLHGFFGLGALIGPLIATsLLTSELSWSWAyLIIGLIY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 170 AAVVTAWMYFRLPETLH------PDDIRPLTASSILGGFKIVLTNRIALCYTLSSTFIFGALFGFINSVEQVYKGIYGlg 243
Cdd:cd17333   161 LLLAILILLTLFPELPSarnpqqSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAG-- 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798 244 awfaAAFAGVALFMAFSSFVNARLVGRFGMRKLSHGSLLGFIAITFVWLLVqvlgpePMPFAIFIVFFALAMFqFGWIGS 323
Cdd:cd17333   239 ----YLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLA------PTLVVGLVATALLGLF-MAALFP 307

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1046555798 324 NFNSLAMEPLGHVAGTASSVMGFMGTVGGSLIGAAIGQSFDGTALPMVAGFFAVsIVGLIFVL 386
Cdd:cd17333   308 TILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITI-LYAIIFVL 369
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
45-154 3.57e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.50  E-value: 3.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  45 YVISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVP--SFSGLLMLRFIQGIGSAATRVITVSIVRDI 122
Cdd:COG2211   268 LLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADV 347

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1046555798 123 -------YGGRQMAEVMSLIMMVFMVVPVIAPGTGQIVL 154
Cdd:COG2211   348 vdydewkTGRRREGLYFGIFTFAIKLGQALAGALAGLLL 386
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 47-125 3.65e-03

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 38.99  E-value: 3.65e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046555798  47 ISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGG 125
Cdd:cd17376    41 TSLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSPSWEMFTVLFVIVGMGQISNYVVAFVLGTEILGK 119
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 54-157 4.01e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 39.15  E-value: 4.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  54 FGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEVMS 133
Cdd:cd17313   294 FLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGRGQGTD 373

                          90       100
                  ....*....|....*....|....*..
gi 1046555798 134 LIMMVFMVVP---VIAPGTGQIVLFFG 157
Cdd:cd17313   374 TGLLNLAISLaqiLVSLLAGPIIDVKG 400
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 52-146 5.15e-03

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 38.75  E-value: 5.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046555798  52 LGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIGSAATRVITVSIVRDIYGGRQMAEV 131
Cdd:cd17438    45 LGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEH 124

                          90
                  ....*....|....*
gi 1046555798 132 MSLIMMVFMVVPVIA 146
Cdd:cd17438   125 LSWLCMFWMIGGLYA 139
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 46-107 6.21e-03

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 38.41  E-value: 6.21e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046555798  46 VISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGIG 107
Cdd:cd17360    40 IVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLG 101
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 46-115 6.52e-03

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 38.40  E-value: 6.52e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1046555798  46 VISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVF---VPSFSGLLMLRFIQGIGSAATRVIT 115
Cdd:cd17357    54 IVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLsksAKSPELLIFGRFLVGIACGLSTGFV 126
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 49-120 7.26e-03

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 38.22  E-value: 7.26e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046555798  49 AYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLMLRFIQGiGSAATRVITVSIVR 120
Cdd:cd17443    44 SYLLGWLLGYIILGAGCDRLGRRAAFVLSLVLATLLGVSVALSASPPTFLVLRLLQG-GTLAGVFLSLYIAR 114
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 46-122 9.15e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 37.97  E-value: 9.15e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046555798  46 VISAYLLGFGIAQLLYGPISDRFGRRKPMFVGLAIYIVSAIAVVFVPSFSGLLML--RFIQGIGSAATRVITVSIVRDI 122
Cdd:cd17332   261 LLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILvlAVLAGIGYGGANLLPWAMLADV 339
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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