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Conserved domains on  [gi|1053177719|ref|WP_065979120|]
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MULTISPECIES: response regulator transcription factor [Pseudoalteromonas]

Protein Classification

response regulator transcription factor( domain architecture ID 11468282)

response regulator transcription factor with a receiver domain and a helix-turn-helix DNA-binding domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 2-175 1.24e-79

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


:

Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 234.04  E-value: 1.24e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   2 NLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGF 81
Cdd:COG4567     6 SLLLVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVVLTGY 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719  82 ASIASAVEAIRLGADDYLPKPVDFVSLLRTlLEGSEAEQPThtlPQTQIMSPERLEWEHIQHVLHRNHGNISETARQLNM 161
Cdd:COG4567    86 ASIATAVEAIKLGADDYLAKPADADDLLAA-LERAEGDAPA---PPENPMSLDRLEWEHIQRVLAECDGNISATARALGM 161

                         170
                  ....*....|....
gi 1053177719 162 HRRTLQRKLQKKPV 175
Cdd:COG4567   162 HRRTLQRKLAKRPP 175
 
Name Accession Description Interval E-value
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 2-175 1.24e-79

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 234.04  E-value: 1.24e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   2 NLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGF 81
Cdd:COG4567     6 SLLLVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVVLTGY 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719  82 ASIASAVEAIRLGADDYLPKPVDFVSLLRTlLEGSEAEQPThtlPQTQIMSPERLEWEHIQHVLHRNHGNISETARQLNM 161
Cdd:COG4567    86 ASIATAVEAIKLGADDYLAKPADADDLLAA-LERAEGDAPA---PPENPMSLDRLEWEHIQRVLAECDGNISATARALGM 161

                         170
                  ....*....|....
gi 1053177719 162 HRRTLQRKLQKKPV 175
Cdd:COG4567   162 HRRTLQRKLAKRPP 175
ActR_PrrA_rreg NF033791
ActR/PrrA/RegA family redox response regulator transcription factor; ActR, PrrA, and RegA are ...
 3-173 1.84e-52

ActR/PrrA/RegA family redox response regulator transcription factor; ActR, PrrA, and RegA are examples of lineage-specific names given to a response regulator transcription factor that acts as a global regulator and belongs to a sensor-regulator pair that is highly conserved in the alpha-proteobacteria. Examples of this regulator include ActR (acid tolerance regulator) in Sinorhizobium meliloti, stationary phase response regulator SpdR in Caulobacter crescentus,


Pssm-ID: 411371 [Multi-domain]  Cd Length: 173  Bit Score: 165.08  E-value: 1.84e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFA 82
Cdd:NF033791    4 LLIVDDDKPFLQRLARAMEKRGFEVTTAESVAEGLAAAKAAPPAFAVVDLRLGDGNGLDVVEALRERRPDARIVVLTGYG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719  83 SIASAVEAIRLGADDYLPKPVD----FVSLLRTllEGSEAEQPTHtlPqtqiMSPERLEWEHIQHVLHRNHGNISETARQ 158
Cdd:NF033791   84 NIATAVAAVKLGAVDYLAKPADaddvEAALLAR--PGEKPEPPEN--P----MSADRVRWEHIQRVYELCDRNVSETARR 155

                         170
                  ....*....|....*
gi 1053177719 159 LNMHRRTLQRKLQKK 173
Cdd:NF033791  156 LNMHRRTLQRILAKR 170
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 1-112 5.20e-52

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 161.84  E-value: 5.20e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTG 80
Cdd:cd17563     1 KSLLLVDDDEVFAERLARALERRGFEVETAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVVLTG 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1053177719  81 FASIASAVEAIRLGADDYLPKPVDFVSLLRTL 112
Cdd:cd17563    81 YASIATAVEAIKLGADDYLAKPADADEILAAL 112
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-109 3.38e-20

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 80.66  E-value: 3.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   4 LIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFAS 83
Cdd:pfam00072   2 LIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHGD 81

                          90       100
                  ....*....|....*....|....*.
gi 1053177719  84 IASAVEAIRLGADDYLPKPVDFVSLL 109
Cdd:pfam00072  82 EDDAVEALEAGADDFLSKPFDPDELL 107
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
3-141 3.61e-18

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 80.66  E-value: 3.61e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFA 82
Cdd:PRK11361    7 ILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILMTAYA 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1053177719  83 SIASAVEAIRLGADDYLPKPVDFVS---LLRTLLEGSEAEQPTHTLPQTqiMSpERLEWEHI 141
Cdd:PRK11361   87 EVETAVEALRCGAFDYVIKPFDLDElnlIVQRALQLQSMKKEIRHLHQA--LS-TSWQWGHI 145
PEP_resp_reg TIGR02915
PEP-CTERM-box response regulator transcription factor; Members of this protein family share ...
 3-104 1.30e-07

PEP-CTERM-box response regulator transcription factor; Members of this protein family share full-length homology with (but do not include) the acetoacetate metabolism regulatory protein AtoC (see SP|Q06065). These proteins have a Fis family DNA binding sequence (pfam02954), a response regulator receiver domain (pfam00072), and sigma-54 interaction domain (pfam00158). [Regulatory functions, DNA interactions]


Pssm-ID: 274348 [Multi-domain]  Cd Length: 445  Bit Score: 50.13  E-value: 1.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLarRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKL-----KDENGLTLIKPMRQQFPRSRIIL 77
Cdd:TIGR02915   1 LLIVEDDLGLQKQL--KWSFADYELAVAADRESAIALVRRHEPAVVTLDLGLppdadGASEGLAALQQILAIAPDTKVIV 78

                          90       100
                  ....*....|....*....|....*..
gi 1053177719  78 LTGFASIASAVEAIRLGADDYLPKPVD 104
Cdd:TIGR02915  79 ITGNDDRENAVKAIGLGAYDFYQKPID 105
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 1-54 1.56e-04

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 37.93  E-value: 1.56e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1053177719    1 MNLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKL 54
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLKEEKPDLILLDIMM 54
 
Name Accession Description Interval E-value
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 2-175 1.24e-79

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 234.04  E-value: 1.24e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   2 NLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGF 81
Cdd:COG4567     6 SLLLVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVVLTGY 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719  82 ASIASAVEAIRLGADDYLPKPVDFVSLLRTlLEGSEAEQPThtlPQTQIMSPERLEWEHIQHVLHRNHGNISETARQLNM 161
Cdd:COG4567    86 ASIATAVEAIKLGADDYLAKPADADDLLAA-LERAEGDAPA---PPENPMSLDRLEWEHIQRVLAECDGNISATARALGM 161

                         170
                  ....*....|....
gi 1053177719 162 HRRTLQRKLQKKPV 175
Cdd:COG4567   162 HRRTLQRKLAKRPP 175
ActR_PrrA_rreg NF033791
ActR/PrrA/RegA family redox response regulator transcription factor; ActR, PrrA, and RegA are ...
 3-173 1.84e-52

ActR/PrrA/RegA family redox response regulator transcription factor; ActR, PrrA, and RegA are examples of lineage-specific names given to a response regulator transcription factor that acts as a global regulator and belongs to a sensor-regulator pair that is highly conserved in the alpha-proteobacteria. Examples of this regulator include ActR (acid tolerance regulator) in Sinorhizobium meliloti, stationary phase response regulator SpdR in Caulobacter crescentus,


Pssm-ID: 411371 [Multi-domain]  Cd Length: 173  Bit Score: 165.08  E-value: 1.84e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFA 82
Cdd:NF033791    4 LLIVDDDKPFLQRLARAMEKRGFEVTTAESVAEGLAAAKAAPPAFAVVDLRLGDGNGLDVVEALRERRPDARIVVLTGYG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719  83 SIASAVEAIRLGADDYLPKPVD----FVSLLRTllEGSEAEQPTHtlPqtqiMSPERLEWEHIQHVLHRNHGNISETARQ 158
Cdd:NF033791   84 NIATAVAAVKLGAVDYLAKPADaddvEAALLAR--PGEKPEPPEN--P----MSADRVRWEHIQRVYELCDRNVSETARR 155

                         170
                  ....*....|....*
gi 1053177719 159 LNMHRRTLQRKLQKK 173
Cdd:NF033791  156 LNMHRRTLQRILAKR 170
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 1-112 5.20e-52

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 161.84  E-value: 5.20e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTG 80
Cdd:cd17563     1 KSLLLVDDDEVFAERLARALERRGFEVETAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVVLTG 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1053177719  81 FASIASAVEAIRLGADDYLPKPVDFVSLLRTL 112
Cdd:cd17563    81 YASIATAVEAIKLGADDYLAKPADADEILAAL 112
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-120 7.65e-29

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 110.05  E-value: 7.65e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTG 80
Cdd:COG2204     3 ARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVILLTG 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1053177719  81 FASIASAVEAIRLGADDYLPKPVDFVSLLRTL---LEGSEAEQ 120
Cdd:COG2204    83 YGDVETAVEAIKAGAFDYLTKPFDLEELLAAVeraLERRRLRR 125
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 3-176 1.29e-24

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 94.64  E-value: 1.29e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFA 82
Cdd:COG0745     4 ILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLTARD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719  83 SIASAVEAIRLGADDYLPKPVDFVSLL---RTLLEGSEAEQPTH---TLPQTQIMSPE-------RLEWE-------HIQ 142
Cdd:COG0745    84 DEEDRVRGLEAGADDYLTKPFDPEELLariRALLRRRAAEVLRVgdlLDLAAREVTRDgepveltPKEFRllellmrNPG 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1053177719 143 HVLHRNH------GNISETARQLNMHRRTLQRKLQKKPVQ 176
Cdd:COG0745   164 RVVSREQlleevwGYDYGDDRTVDVHISRLRKKLEDDLIE 203
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 4-102 1.39e-24

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 91.52  E-value: 1.39e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   4 LIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFAS 83
Cdd:cd00156     1 LIVDDDPAIRELLKSLLEREGYEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAKAD 80

                          90
                  ....*....|....*....
gi 1053177719  84 IASAVEAIRLGADDYLPKP 102
Cdd:cd00156    81 EEDAVRALELGADDYLVKP 99
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-112 5.77e-24

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 91.18  E-value: 5.77e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDDINLANTLARRFTKHGFCCQL--AHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILL 78
Cdd:COG4565     4 IRVLIVEDDPMVAELLRRYLERLPGFEVVgvASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDVIVI 83

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1053177719  79 TGFASIASAVEAIRLGADDYLPKPVDFVSLLRTL 112
Cdd:COG4565    84 TAARDPETVREALRAGVVDYLIKPFTFERLREAL 117
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 4-102 8.80e-22

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 84.38  E-value: 8.80e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   4 LIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFAS 83
Cdd:cd17574     1 LVVEDDEEIAELLSDYLEKEGYEVDTAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTAKDE 80

                          90
                  ....*....|....*....
gi 1053177719  84 IASAVEAIRLGADDYLPKP 102
Cdd:cd17574    81 EEDKVLGLELGADDYITKP 99
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-114 3.78e-21

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 83.75  E-value: 3.78e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQ--QFPRSRIILL 78
Cdd:COG0784     6 KRILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIRAlpRLPDIPIIAL 85

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1053177719  79 TGFASIASAVEAIRLGADDYLPKPVDFVSLLRTLLE 114
Cdd:COG0784    86 TAYADEEDRERALEAGADDYLTKPVDPEELLEALRR 121
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 2-102 3.09e-20

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 80.59  E-value: 3.09e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   2 NLLIIEDDINLANTLARRFTKH-GF-CCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLT 79
Cdd:COG4753     1 KVLIVDDEPLIREGLKRILEWEaGFeVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIILS 80

                          90       100
                  ....*....|....*....|...
gi 1053177719  80 GFASIASAVEAIRLGADDYLPKP 102
Cdd:COG4753    81 GYSDFEYAQEAIKLGADDYLLKP 103
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-109 3.38e-20

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 80.66  E-value: 3.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   4 LIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFAS 83
Cdd:pfam00072   2 LIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHGD 81

                          90       100
                  ....*....|....*....|....*.
gi 1053177719  84 IASAVEAIRLGADDYLPKPVDFVSLL 109
Cdd:pfam00072  82 EDDAVEALEAGADDFLSKPFDPDELL 107
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 3-113 9.90e-20

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 79.45  E-value: 9.90e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFA 82
Cdd:cd17624     1 ILLVEDDALLGDGLKTGLRKAGYAVDWVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLILTARD 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1053177719  83 SIASAVEAIRLGADDYLPKPVDFVSL---LRTLL 113
Cdd:cd17624    81 GVDDRVAGLDAGADDYLVKPFALEELlarLRALL 114
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 1-112 5.55e-19

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 79.57  E-value: 5.55e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQfPRSR---IIL 77
Cdd:COG3706     2 ARILVVDDDPTNRKLLRRLLEAAGYEVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRAD-PRTAdipIIF 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1053177719  78 LTGFASIASAVEAIRLGADDYLPKPVDFVSLLRTL 112
Cdd:COG3706    81 LTALDDEEDRARALEAGADDYLTKPFDPEELLARV 115
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 2-113 1.73e-18

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 76.51  E-value: 1.73e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   2 NLLIIEDDINLANTLARRFTKH-GF-CCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLT 79
Cdd:cd19925     2 NVLIVEDDPMVAEIHRAYVEQVpGFtVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVVT 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1053177719  80 GfASIASAV-EAIRLGADDYLPKPVDFVSLLRTLL 113
Cdd:cd19925    82 A-ANDVETVrEALRLGVVDYLIKPFTFERLRQRLE 115
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 3-112 1.89e-18

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 76.38  E-value: 1.89e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFA 82
Cdd:cd17550     1 ILIVDDEEDIRESLSGILEDEGYEVDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIMISGHG 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1053177719  83 SIASAVEAIRLGADDYLPKPVDFVSLLRTL 112
Cdd:cd17550    81 TIETAVKATKLGAYDFIEKPLSLDRLLLTI 110
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
3-141 3.61e-18

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 80.66  E-value: 3.61e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFA 82
Cdd:PRK11361    7 ILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILMTAYA 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1053177719  83 SIASAVEAIRLGADDYLPKPVDFVS---LLRTLLEGSEAEQPTHTLPQTqiMSpERLEWEHI 141
Cdd:PRK11361   87 EVETAVEALRCGAFDYVIKPFDLDElnlIVQRALQLQSMKKEIRHLHQA--LS-TSWQWGHI 145
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 3-103 8.71e-18

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 74.54  E-value: 8.71e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFA 82
Cdd:cd17555     3 ILVIDDDEVVRESIAAYLEDSGFQVLQAADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPDTPVIVVSGAG 82

                          90       100
                  ....*....|....*....|.
gi 1053177719  83 SIASAVEAIRLGADDYLPKPV 103
Cdd:cd17555    83 VMSDAVEALRLGAWDYLTKPI 103
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 3-104 1.71e-17

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 74.16  E-value: 1.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFA 82
Cdd:cd17572     1 VLLVEDSPSLAALYQEYLSDEGYKVTHVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVITAHG 80

                          90       100
                  ....*....|....*....|..
gi 1053177719  83 SIASAVEAIRLGADDYLPKPVD 104
Cdd:cd17572    81 SVDIAVEAMRLGAYDFLEKPFD 102
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 4-113 3.58e-17

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 73.02  E-value: 3.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   4 LIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDicSAFSPSHFLV--DLKLKDENGLTLIKPMRQQFPRSRIILLTGF 81
Cdd:cd17625     1 LVVEDEKDLSEAITKHLKKEGYTVDVCFDGEEGLE--YALSGIYDLIilDIMLPGMDGLEVLKSLREEGIETPVLLLTAL 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1053177719  82 ASIASAVEAIRLGADDYLPKPVDFVSLL---RTLL 113
Cdd:cd17625    79 DAVEDRVKGLDLGADDYLPKPFSLAELLariRALL 113
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 1-114 3.23e-16

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 73.28  E-value: 3.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQfPRSR---IIL 77
Cdd:COG3437     7 PTVLIVDDDPENLELLRQLLRTLGYDVVTAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLRAD-PSTRdipVIF 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1053177719  78 LTGFASIASAVEAIRLGADDYLPKPVD---FVSLLRTLLE 114
Cdd:COG3437    86 LTALADPEDRERALEAGADDYLTKPFDpeeLLARVRNALE 125
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 5-104 1.53e-15

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 68.84  E-value: 1.53e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   5 IIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFASI 84
Cdd:cd19919     5 IVDDDSSIRWVLERALAGAGLTVTSFENAQEALAALASSQPDVLISDIRMPGMDGLALLAQIKQRHPDLPVIIMTAHSDL 84

                          90       100
                  ....*....|....*....|
gi 1053177719  85 ASAVEAIRLGADDYLPKPVD 104
Cdd:cd19919    85 DSAVSAYQGGAFEYLPKPFD 104
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 3-114 1.94e-15

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 68.52  E-value: 1.94e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRF--TKHGF-CCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLT 79
Cdd:cd17536     1 VLIVDDEPLIREGLKKLIdwEELGFeVVGEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIILS 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1053177719  80 GFASIASAVEAIRLGADDYLPKPVDFVSLLRTLLE 114
Cdd:cd17536    81 GYDDFEYAQKAIRLGVVDYLLKPVDEEELEEALEK 115
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 5-120 6.86e-15

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 68.97  E-value: 6.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   5 IIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFASI 84
Cdd:COG4566     4 IVDDDEAVRDSLAFLLESAGLRVETFASAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELAARGSPLPVIFLTGHGDV 83

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1053177719  85 ASAVEAIRLGADDYLPKPVDFVSLLRTLLEGSEAEQ 120
Cdd:COG4566    84 PMAVRAMKAGAVDFLEKPFDDQALLDAVRRALARDR 119
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
1-127 1.33e-14

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 70.44  E-value: 1.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTG 80
Cdd:PRK10365    6 IDILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIMTA 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1053177719  81 FASIASAVEAIRLGADDYLPKPVDFVSLLRTLLEG------SEAEQPTHTLPQ 127
Cdd:PRK10365   86 YSSVETAVEALKTGALDYLIKPLDFDNLQATLEKAlahthsIDAETPAVTASQ 138
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-112 2.53e-14

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 68.30  E-value: 2.53e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDDINLANTLARRFTKHGF--CCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILL 78
Cdd:COG3279     2 MKILIVDDEPLARERLERLLEKYPDleVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIFT 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1053177719  79 TGFASIAsaVEAIRLGADDYLPKPVDFVSLLRTL 112
Cdd:COG3279    82 TAYDEYA--LEAFEVNAVDYLLKPIDEERLAKAL 113
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 3-102 2.85e-14

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 65.15  E-value: 2.85e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFA 82
Cdd:cd19935     1 ILVVEDEKKLAEYLKKGLTEEGYAVDVAYDGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAGKQTPVLMLTARD 80

                          90       100
                  ....*....|....*....|
gi 1053177719  83 SIASAVEAIRLGADDYLPKP 102
Cdd:cd19935    81 SVEDRVKGLDLGADDYLVKP 100
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 3-104 4.50e-14

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 65.02  E-value: 4.50e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSrIILLTGFA 82
Cdd:cd17623     1 ILLIDDDRELTELLTEYLEMEGFNVRAAHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKTSQVP-VLMLTARG 79

                          90       100
                  ....*....|....*....|..
gi 1053177719  83 SIASAVEAIRLGADDYLPKPVD 104
Cdd:cd17623    80 DDIDRILGLELGADDYLPKPFN 101
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 1-113 6.24e-14

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 66.87  E-value: 6.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTG 80
Cdd:PRK09836    1 MKLLIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKGMPILLLTA 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1053177719  81 FASIASAVEAIRLGADDYLPKPVDFVSLL---RTLL 113
Cdd:PRK09836   81 LGTIEHRVKGLELGADDYLVKPFAFAELLarvRTLL 116
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 3-112 6.87e-14

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 64.41  E-value: 6.87e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDD-INLanTLARRF-TKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQF---PRSRIIL 77
Cdd:cd17546     1 VLVVDDNpVNR--KVLKKLlEKLGYEVDVAENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIRELEgggRRTPIIA 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1053177719  78 LTGFASIASAVEAIRLGADDYLPKPVDFVSLLRTL 112
Cdd:cd17546    79 LTANALEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 4-114 9.87e-14

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 64.43  E-value: 9.87e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   4 LIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFAS 83
Cdd:cd17549     2 LLVDDDADVREALQQTLELAGFRVRAFADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELDPDLPVILITGHGD 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1053177719  84 IASAVEAIRLGADDYLPKPVD---FVSLLRTLLE 114
Cdd:cd17549    82 VPMAVEAMRAGAYDFLEKPFDperLLDVVRRALE 115
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 3-113 1.51e-13

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 63.53  E-value: 1.51e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFA 82
Cdd:cd17615     2 VLVVDDEPNITELLSMALRYEGWDVETAADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVLFLTAKD 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1053177719  83 SIASAVEAIRLGADDYLPKPV---DFVSLLRTLL 113
Cdd:cd17615    82 SVEDRIAGLTAGGDDYVTKPFsleEVVARLRALL 115
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 3-103 2.32e-13

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 63.16  E-value: 2.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFpRSRIILLTGFA 82
Cdd:cd19939     2 ILIVEDELELARLTRDYLIKAGLEVSVFTDGQRAVRRIIDEQPSLVVLDIMLPGMDGLTVCREVREHS-HVPILMLTART 80

                          90       100
                  ....*....|....*....|.
gi 1053177719  83 SIASAVEAIRLGADDYLPKPV 103
Cdd:cd19939    81 EEMDRVLGLEMGADDYLCKPF 101
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 2-122 2.43e-13

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 66.82  E-value: 2.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   2 NLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGF 81
Cdd:PRK10923    5 IVWVVDDDSSIRWVLERALAGAGLTCTTFENGNEVLEALASKTPDVLLSDIRMPGMDGLALLKQIKQRHPMLPVIIMTAH 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1053177719  82 ASIASAVEAIRLGADDYLPKPVDF---VSLL-RTLLEGSEAEQPT 122
Cdd:PRK10923   85 SDLDAAVSAYQQGAFDYLPKPFDIdeaVALVeRAISHYQEQQQPR 129
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 3-102 2.45e-13

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 63.07  E-value: 2.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQ---FPrsrIILLT 79
Cdd:cd19934     1 LLLVEDDALLAAQLKEQLSDAGYVVDVAEDGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEgraTP---VLILT 77

                          90       100
                  ....*....|....*....|...
gi 1053177719  80 GFASIASAVEAIRLGADDYLPKP 102
Cdd:cd19934    78 ARDSWQDKVEGLDAGADDYLTKP 100
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 4-112 3.38e-13

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 62.48  E-value: 3.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   4 LIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIIL--LTGF 81
Cdd:cd17580     2 LVVDDNEDAAEMLALLLELEGAEVTTAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLRELPWLANTPAiaLTGY 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1053177719  82 ASIASAVEAIRLGADDYLPKPVDFVSLLRTL 112
Cdd:cd17580    82 GQPEDRERALEAGFDAHLVKPVDPDELIELI 112
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
 3-109 4.50e-13

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 62.06  E-value: 4.50e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFA 82
Cdd:cd17573     1 ILLIEDDSTLGKEISKGLNEKGYQADVAESLKDGEYYIDIRNYDLVLVSDKLPDGNGLSIVSRIKEKHPSIVVIVLSDNP 80

                          90       100
                  ....*....|....*....|....*..
gi 1053177719  83 SIASAVEAIRLGADDYLPKPVDFVSLL 109
Cdd:cd17573    81 KTEQEIEAFKEGADDYIAKPFDFKVLV 107
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 4-102 6.69e-13

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 61.41  E-value: 6.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   4 LIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQ--QFPrsrIILLTGF 81
Cdd:cd17620     2 LVIEDEPQIRRFLRTALEAHGYRVFEAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRLREwsAVP---VIVLSAR 78

                          90       100
                  ....*....|....*....|.
gi 1053177719  82 ASIASAVEAIRLGADDYLPKP 102
Cdd:cd17620    79 DEESDKIAALDAGADDYLTKP 99
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 3-113 1.08e-12

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 61.24  E-value: 1.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFpRSRIILLTGFA 82
Cdd:cd17622     3 ILLVEDDPKLARLIADFLESHGFNVVVEHRGDRALEVIAREKPDAVLLDIMLPGIDGLTLCRDLRPKY-QGPILLLTALD 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1053177719  83 SIASAVEAIRLGADDYLPKPVD---FVSLLRTLL 113
Cdd:cd17622    82 SDIDHILGLELGADDYVVKPVEpavLLARLRALL 115
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
1-170 1.56e-12

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 63.28  E-value: 1.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MN-LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAfSPSHFLVDLKLKDENGLTLIKPMRQQFpRSRIILLT 79
Cdd:PRK10955    1 MNkILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLLDD-SIDLLLLDVMMPKKNGIDTLKELRQTH-QTPVIMLT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719  80 GFASIASAVEAIRLGADDYLPKPV---DFVSLLRTLLEGS---EAEQPT-HTLPQTQI----MSPERLE----------- 137
Cdd:PRK10955   79 ARGSELDRVLGLELGADDYLPKPFndrELVARIRAILRRShwsEQQQNNdNGSPTLEVdalsLNPGRQEasfdgqtlelt 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1053177719 138 ----------WEHIQHVLHRNH-------GNISETARQLNMHRRTLQRKL 170
Cdd:PRK10955  159 gteftllyllAQHLGQVVSREHlsqevlgKRLTPFDRAIDMHISNLRRKL 208
PRK10643 PRK10643
two-component system response regulator PmrA;
1-102 2.23e-12

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 62.75  E-value: 2.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAidiCSAFSPSHF---LVDLKLKDENGLTLIKPMRQQFPRSRIIL 77
Cdd:PRK10643    1 MKILIVEDDTLLLQGLILALQTEGYACDCASTAREA---EALLESGHYslvVLDLGLPDEDGLHLLRRWRQKKYTLPVLI 77

                          90       100
                  ....*....|....*....|....*
gi 1053177719  78 LTGFASIASAVEAIRLGADDYLPKP 102
Cdd:PRK10643   78 LTARDTLEDRVAGLDVGADDYLVKP 102
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 2-117 4.03e-12

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 59.72  E-value: 4.03e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   2 NLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDIcSAFSPSHFLV-DLKLKDENGLTLIKPMRQQFPRSRIILLTG 80
Cdd:cd17569     2 TILLVDDEPNILKALKRLLRREGYEVLTATSGEEALEI-LKQEPVDVVIsDQRMPGMDGAELLKRVRERYPDTVRILLTG 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1053177719  81 FASIASAVEAIRLGA-DDYLPKPVDFVSLLRTLLEGSE 117
Cdd:cd17569    81 YADLDAAIEAINEGEiYRFLTKPWDDEELKETIRQALE 118
PRK15115 PRK15115
response regulator GlrR; Provisional
 2-121 4.56e-12

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 63.32  E-value: 4.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   2 NLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGF 81
Cdd:PRK15115    7 HLLLVDDDPGLLKLLGMRLTSEGYSVVTAESGQEALRVLNREKVDLVISDLRMDEMDGMQLFAEIQKVQPGMPVIILTAH 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1053177719  82 ASIASAVEAIRLGADDYLPKPVDFVSLLRTLLEGSEAEQP 121
Cdd:PRK15115   87 GSIPDAVAATQQGVFSFLTKPVDRDALYKAIDDALEQSAP 126
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 2-109 5.07e-12

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 59.32  E-value: 5.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   2 NLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQfPRSRIILLTGF 81
Cdd:cd17619     2 HILIVEDEPVTRATLKSYFEQEGYDVSEAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELREQ-SEVGIILVTGR 80

                          90       100
                  ....*....|....*....|....*...
gi 1053177719  82 ASIASAVEAIRLGADDYLPKPVDFVSLL 109
Cdd:cd17619    81 DDEVDRIVGLEIGADDYVTKPFNPRELL 108
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 3-104 6.24e-12

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 59.35  E-value: 6.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFA 82
Cdd:cd17616     1 VLLIEDDSATAQSIELMLKSEGFNVYTTDLGEEGLDLGKLYDYDIILLDLNLPDMSGYEVLRTLRLAKVKTPILILSGLA 80

                          90       100
                  ....*....|....*....|..
gi 1053177719  83 SIASAVEAIRLGADDYLPKPVD 104
Cdd:cd17616    81 DIEDKVKGLGFGADDYMTKPFH 102
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 3-109 8.05e-12

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 58.83  E-value: 8.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPrSRIILLTGFA 82
Cdd:cd18159     1 ILIVEDDETIASLLKKHLEKWGYEVVLIEDFEDVLEEFLQFKPDLVLLDINLPYFDGFYWCREIRQISN-VPIIFISSRD 79

                          90       100
                  ....*....|....*....|....*..
gi 1053177719  83 SIASAVEAIRLGADDYLPKPVDFVSLL 109
Cdd:cd18159    80 DNMDQVMAINMGGDDYITKPFDLDVLL 106
ompR PRK09468
osmolarity response regulator; Provisional
 3-102 2.55e-11

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 59.99  E-value: 2.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQaIDICSAFSPSHFLV-DLKLKDENGLTLIKPMRQQFPRSRIILLTGF 81
Cdd:PRK09468    8 ILVVDDDMRLRALLERYLTEQGFQVRSAANAEQ-MDRLLTRESFHLMVlDLMLPGEDGLSICRRLRSQNNPTPIIMLTAK 86

                          90       100
                  ....*....|....*....|.
gi 1053177719  82 ASIASAVEAIRLGADDYLPKP 102
Cdd:PRK09468   87 GEEVDRIVGLEIGADDYLPKP 107
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 34-112 2.80e-11

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 57.52  E-value: 2.80e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1053177719  34 QQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFASIASAVEAIRLGADDYLPKPVDFVSLLRTL 112
Cdd:cd17535    34 EEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLTAHDDPEYVLRALKAGAAGYLLKDSSPEELIEAI 112
RocR COG3829
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...
 108-172 3.57e-11

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 443041 [Multi-domain]  Cd Length: 448  Bit Score: 60.56  E-value: 3.57e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1053177719 108 LLRTLLEGSEAEQPTHTLPQTQIMspERLEWEHIQHVLHRNHGNISETARQLNMHRRTLQRKLQK 172
Cdd:COG3829   382 LPEYLLEEAEAASAAEEGSLKEAL--EEVEKELIEEALEKTGGNKSKAAKALGISRSTLYRKLKK 444
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 5-104 5.69e-11

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 56.83  E-value: 5.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   5 IIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFASI 84
Cdd:cd17537     5 VVDDDEAVRDSLAFLLRSVGLAVKTFTSASAFLAAAPPDQPGCLVLDVRMPGMSGLELQDELLARGSNIPIIFITGHGDV 84

                          90       100
                  ....*....|....*....|
gi 1053177719  85 ASAVEAIRLGADDYLPKPVD 104
Cdd:cd17537    85 PMAVEAMKAGAVDFLEKPFR 104
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 3-113 6.48e-11

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 56.62  E-value: 6.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFA 82
Cdd:cd17627     1 ILVVDDDRAVRESLRRSLRFEGYEVETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLTARD 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1053177719  83 SIASAVEAIRLGADDYLPKPVDFVSLL---RTLL 113
Cdd:cd17627    81 SVSDRVAGLDAGADDYLVKPFALEELLarvRALL 114
dpiA PRK10046
two-component response regulator DpiA; Provisional
 1-112 1.07e-10

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 58.11  E-value: 1.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDDINLANTLARrFTKH--GFC-CQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIIL 77
Cdd:PRK10046    5 LTLLIVEDETPLAEMHAE-YIRHipGFSqILLAGNLAQARMMIERFKPGLILLDNYLPDGRGINLLHELVQAHYPGDVVF 83

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1053177719  78 LTGFASIASAVEAIRLGADDYLPKPVDFVSLLRTL 112
Cdd:PRK10046   84 TTAASDMETVSEAVRCGVFDYLIKPIAYERLGQTL 118
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 3-102 1.19e-10

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 55.89  E-value: 1.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFpRSRIILLTGFA 82
Cdd:cd17614     1 ILVVDDEKPISDILKFNLTKEGYEVVTAYDGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTS-NVPIIMLTAKD 79

                          90       100
                  ....*....|....*....|
gi 1053177719  83 SIASAVEAIRLGADDYLPKP 102
Cdd:cd17614    80 SEVDKVLGLELGADDYVTKP 99
orf27 CHL00148
Ycf27; Reviewed
 1-148 1.78e-10

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 57.80  E-value: 1.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQ--FPrsrIILL 78
Cdd:CHL00148    7 EKILVVDDEAYIRKILETRLSIIGYEVITASDGEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEIRKEsdVP---IIML 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1053177719  79 TGFASIASAVEAIRLGADDYLPKPVDFVSL---LRTLLEGSEAEQPTHTLPQTQIMSPERLEWEHIQHVLHRN 148
Cdd:CHL00148   84 TALGDVSDRITGLELGADDYVVKPFSPKELearIRSVLRRTNKKSFSSKIPNSSIIRIGFLKIDLNKKQVYKN 156
HTH_8 pfam02954
Bacterial regulatory protein, Fis family;
134-172 2.60e-10

Bacterial regulatory protein, Fis family;


Pssm-ID: 427077 [Multi-domain]  Cd Length: 40  Bit Score: 53.17  E-value: 2.60e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1053177719 134 ERLEWEHIQHVLHRNHGNISETARQLNMHRRTLQRKLQK 172
Cdd:pfam02954   2 EEVEKELIEAALERTGGNKSKAARLLGISRRTLYRKLKK 40
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-114 3.97e-10

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 56.12  E-value: 3.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDDINLANTLARRFTKHGF-CCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSrIILLT 79
Cdd:COG3707     4 LRVLVVDDEPLRRADLREGLREAGYeVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPAP-VILLT 82

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1053177719  80 GFASIASAVEAIRLGADDYLPKPVDfVSLLRTLLE 114
Cdd:COG3707    83 AYSDPELIERALEAGVSAYLVKPLD-PEDLLPALE 116
fixJ PRK09390
response regulator FixJ; Provisional
 5-171 4.35e-10

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 56.16  E-value: 4.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   5 IIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFASI 84
Cdd:PRK09390    8 VVDDDEAMRDSLAFLLDSAGFEVRLFESAQAFLDALPGLRFGCVVTDVRMPGIDGIELLRRLKARGSPLPVIVMTGHGDV 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719  85 ASAVEAIRLGADDYLPKPVD---FVSLLRTLLEGSEAEQPTHTLPQT-----QIMSP-ER-----LEWEHIQHVLHRNHG 150
Cdd:PRK09390   88 PLAVEAMKLGAVDFIEKPFEderLIGAIERALAQAPEAAKSEAVAADirariASLSErERqvmdgLVAGLSNKVIARDLD 167

                         170       180
                  ....*....|....*....|.
gi 1053177719 151 nISetARQLNMHRRTLQRKLQ 171
Cdd:PRK09390  168 -IS--PRTVEVYRANVMTKMQ 185
PRK15479 PRK15479
transcriptional regulator TctD;
1-117 7.92e-10

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 55.88  E-value: 7.92e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTG 80
Cdd:PRK15479    1 MRLLLAEDNRELAHWLEKALVQNGFAVDCVFDGLAADHLLQSEMYALAVLDINMPGMDGLEVLQRLRKRGQTLPVLLLTA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1053177719  81 FASIASAVEAIRLGADDYLPKPVDFVSL---LRTLLEGSE 117
Cdd:PRK15479   81 RSAVADRVKGLNVGADDYLPKPFELEELdarLRALLRRSA 120
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 4-109 1.08e-09

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 53.22  E-value: 1.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   4 LIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMR--QQFPrsrIILLTGF 81
Cdd:cd17594     3 LVVDDDAAMRHLLILYLRERGFDVTAAADGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTIRarSDVP---IIIISGD 79

                          90       100
                  ....*....|....*....|....*....
gi 1053177719  82 ASIASA-VEAIRLGADDYLPKPVDFVSLL 109
Cdd:cd17594    80 RRDEIDrVVGLELGADDYLAKPFGLRELL 108
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 2-102 1.60e-09

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 53.02  E-value: 1.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   2 NLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQfPRSR---IILL 78
Cdd:cd17618     2 TILIVEDEPAIREMIAFNLERAGFDVVEAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLKRD-EMTRdipIIML 80

                          90       100
                  ....*....|....*....|....
gi 1053177719  79 TGFASIASAVEAIRLGADDYLPKP 102
Cdd:cd17618    81 TARGEEEDKVRGLEAGADDYITKP 104
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 3-104 2.24e-09

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 52.56  E-value: 2.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFA 82
Cdd:cd17553     3 ILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYG 82

                          90       100
                  ....*....|....*....|..
gi 1053177719  83 SIASAVEAIRLGADDYLPKPVD 104
Cdd:cd17553    83 ELDMIQESKELGALTHFAKPFD 104
PRK10336 PRK10336
two-component system response regulator QseB;
1-102 2.38e-09

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 54.52  E-value: 2.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTG 80
Cdd:PRK10336    1 MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA 80

                          90       100
                  ....*....|....*....|..
gi 1053177719  81 FASIASAVEAIRLGADDYLPKP 102
Cdd:PRK10336   81 RDALAERVEGLRLGADDYLCKP 102
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 134-172 4.73e-09

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 54.20  E-value: 4.73e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1053177719 134 ERLEWEHIQHVLHRNHGNISETARQLNMHRRTLQRKLQK 172
Cdd:COG2204   378 EEVERELIERALEETGGNVSRAAELLGISRRTLYRKLKK 416
PRK10816 PRK10816
two-component system response regulator PhoP;
1-102 6.92e-09

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 53.20  E-value: 6.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTG 80
Cdd:PRK10816    1 MRVLVVEDNALLRHHLKVQLQDAGHQVDAAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILVLTA 80

                          90       100
                  ....*....|....*....|..
gi 1053177719  81 FASIASAVEAIRLGADDYLPKP 102
Cdd:PRK10816   81 RESWQDKVEVLSAGADDYVTKP 102
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 1-104 9.41e-09

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 50.74  E-value: 9.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDDINLANTLARRFTKHGFCCQL-AHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLT 79
Cdd:cd17542     1 KKVLIVDDAAFMRMMLKDILTKAGYEVVGeAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIMCS 80

                          90       100
                  ....*....|....*....|....*
gi 1053177719  80 GFASIASAVEAIRLGADDYLPKPVD 104
Cdd:cd17542    81 AMGQEEMVKEAIKAGAKDFIVKPFQ 105
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 4-109 1.87e-08

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 49.96  E-value: 1.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   4 LIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSR--IILLTGF 81
Cdd:cd19937     1 LVVDDEEDIVELLKYNLEKEGYEVVTAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILRSDPKTSSipIIMLTAK 80

                          90       100
                  ....*....|....*....|....*...
gi 1053177719  82 ASIASAVEAIRLGADDYLPKPVDFVSLL 109
Cdd:cd19937    81 GEEFDKVLGLELGADDYITKPFSPRELL 108
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 3-103 3.23e-08

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 49.03  E-value: 3.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQfPRSR---IILLT 79
Cdd:cd17538     2 ILVVDDEPANRELLEALLSAEGYEVLTADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLKED-PETRhipVIMIT 80

                          90       100
                  ....*....|....*....|....
gi 1053177719  80 GFASIASAVEAIRLGADDYLPKPV 103
Cdd:cd17538    81 ALDDREDRIRGLEAGADDFLSKPI 104
FhlA COG3604
FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis ...
 134-172 3.93e-08

FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 442823 [Multi-domain]  Cd Length: 338  Bit Score: 51.77  E-value: 3.93e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1053177719 134 ERLEWEHIQHVLHRNHGNISETARQLNMHRRTLQRKLQK 172
Cdd:COG3604   296 EEVEREHILEALERTGGNIAGAARLLGLTPSTLRSRMKK 334
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 1-112 6.06e-08

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 48.56  E-value: 6.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDDINLANTLARRFTKHGF-CCQLAHSCQQAIDICSAFSPSHFLVDLKLKDE-NGLTLIKPMRQQF--PrsrII 76
Cdd:cd17534     1 KKILIVEDEAIIALDLKEILESLGYeVVGIADSGEEAIELAEENKPDLILMDINLKGDmDGIEAAREIREKFdiP---VI 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1053177719  77 LLTGFASIASAVEAIRLGADDYLPKPVDFVSLLRTL 112
Cdd:cd17534    78 FLTAYSDEETLERAKETNPYGYLVKPFNERELKAAI 113
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 3-102 6.59e-08

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 48.53  E-value: 6.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRqQFPRSRIILLTGFA 82
Cdd:cd19938     2 ILIVEDEPKLAQLLIDYLRAAGYAPTLLAHGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREIR-RFSDVPIIMVTARV 80

                          90       100
                  ....*....|....*....|
gi 1053177719  83 SIASAVEAIRLGADDYLPKP 102
Cdd:cd19938    81 EEIDRLLGLELGADDYICKP 100
AcoR COG3284
Transcriptional regulator DhaR of acetoin/glycerol metabolism [Transcription];
112-172 1.18e-07

Transcriptional regulator DhaR of acetoin/glycerol metabolism [Transcription];


Pssm-ID: 442514 [Multi-domain]  Cd Length: 625  Bit Score: 50.28  E-value: 1.18e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1053177719 112 LLEGSEAEQPTHTLPQTQImspERLEWEHIQHVLHRNHGNISETARQLNMHRRTLQRKLQK 172
Cdd:COG3284   566 LRAELAAAAPAAAAPLTSL---EEAERDAILRALRACGGNVSAAARALGISRSTLYRKLKR 623
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 30-114 1.30e-07

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 47.73  E-value: 1.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719  30 AHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFASIASAVEAIRLGADDYLPKPVDFVSLL 109
Cdd:cd19931    30 ASSGEEGIELAERLDPDLILLDLNMKGMSGLDTLKALREEGVSARIVILTVSDAEDDVVTALRAGADGYLLKDMEPEDLL 109


                  ....*
gi 1053177719 110 RTLLE 114
Cdd:cd19931   110 EALKQ 114
PEP_resp_reg TIGR02915
PEP-CTERM-box response regulator transcription factor; Members of this protein family share ...
 3-104 1.30e-07

PEP-CTERM-box response regulator transcription factor; Members of this protein family share full-length homology with (but do not include) the acetoacetate metabolism regulatory protein AtoC (see SP|Q06065). These proteins have a Fis family DNA binding sequence (pfam02954), a response regulator receiver domain (pfam00072), and sigma-54 interaction domain (pfam00158). [Regulatory functions, DNA interactions]


Pssm-ID: 274348 [Multi-domain]  Cd Length: 445  Bit Score: 50.13  E-value: 1.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLarRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKL-----KDENGLTLIKPMRQQFPRSRIIL 77
Cdd:TIGR02915   1 LLIVEDDLGLQKQL--KWSFADYELAVAADRESAIALVRRHEPAVVTLDLGLppdadGASEGLAALQQILAIAPDTKVIV 78

                          90       100
                  ....*....|....*....|....*..
gi 1053177719  78 LTGFASIASAVEAIRLGADDYLPKPVD 104
Cdd:TIGR02915  79 ITGNDDRENAVKAIGLGAYDFYQKPID 105
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 2-111 1.40e-07

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 47.53  E-value: 1.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   2 NLLIIEDD-INLanTLARRFTK-HGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQfPRSR---II 76
Cdd:cd17548     1 KILIVEDNpLNM--KLARDLLEsAGYEVLEAADGEEALEIARKEKPDLILMDIQLPGMDGLEATRLLKED-PATRdipVI 77

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1053177719  77 LLTGFASIASAVEAIRLGADDYLPKPVDFVSLLRT 111
Cdd:cd17548    78 ALTAYAMKGDREKILEAGCDGYISKPIDTREFLET 112
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 3-102 1.46e-07

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 47.37  E-value: 1.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQ--FPRSRIILLTG 80
Cdd:cd19927     1 ILLVDDDPGIRLAVKDYLEDQGFTVIAASNGLEALDLLNQYIPDLIISDIIMPGVDGYSLLGKLRKNadFDTIPVIFLTA 80

                          90       100
                  ....*....|....*....|..
gi 1053177719  81 FASIASAVEAIRLGADDYLPKP 102
Cdd:cd19927    81 KGMTSDRIKGYNAGCDGYLSKP 102
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 5-102 1.55e-07

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 47.44  E-value: 1.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   5 IIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQ--FPrsrIILLTGFA 82
Cdd:cd19936     3 LVDDDRNILTSVSMALEAEGFSVETYTDGASALDGLNARPPDLAILDIKMPRMDGMELLQRLRQKstLP---VIFLTSKD 79

                          90       100
                  ....*....|....*....|
gi 1053177719  83 SIASAVEAIRLGADDYLPKP 102
Cdd:cd19936    80 DEIDEVFGLRMGADDYITKP 99
PRK10430 PRK10430
two-component system response regulator DcuR;
1-157 1.65e-07

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 49.34  E-value: 1.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDDINLANtLARRFTKH--GF-CCQLAHSCQQAIDICSAfSPSHF---LVDLKLKDENGLTLIKPMRQQFPRSR 74
Cdd:PRK10430    2 INVLIVDDDAMVAE-LNRRYVAQipGFqCCGTASTLEQAKEIIFN-SDTPIdliLLDIYMQQENGLDLLPVLHEAGCKSD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719  75 IILLTGFASIASAVEAIRLGADDYLPKPVDFVSLlrtllegseAEQPTHTLPQTQIM-SPERLEWEHIQHVLHRNHGNIS 153
Cdd:PRK10430   80 VIVISSAADAATIKDSLHYGVVDYLIKPFQASRF---------EEALTGWRQKKMALeKHQYYDQAELDQLIHGSSSNEQ 150


                  ....
gi 1053177719 154 ETAR 157
Cdd:PRK10430  151 DPRR 154
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 3-102 1.71e-07

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 47.46  E-value: 1.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQ--FPrsrIILLTG 80
Cdd:cd17626     3 ILVVDDDAALAEMIGIVLRGEGFDPAFCGDGTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQIRAEsgVP---IVMLTA 79

                          90       100
                  ....*....|....*....|..
gi 1053177719  81 FASIASAVEAIRLGADDYLPKP 102
Cdd:cd17626    80 KSDTVDVVLGLESGADDYVAKP 101
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
 49-102 2.00e-07

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 47.11  E-value: 2.00e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1053177719  49 LVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFASIASAVEAIRLGADDYLPKP 102
Cdd:cd19928    47 ITDVVMPDENGLDLIPRIKKARPDLPIIVMSAQNTLMTAVKAAERGAFEYLPKP 100
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 4-102 2.28e-07

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 46.76  E-value: 2.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   4 LIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFAS 83
Cdd:cd19926     2 LVVDDEPDIRELLEITLGRMGLDVRSARNVKEARELLASEPYDLCLTDMRLPDGSGLELVQHIQQRLPQTPVAVITAYGS 81

                          90
                  ....*....|....*....
gi 1053177719  84 IASAVEAIRLGADDYLPKP 102
Cdd:cd19926    82 LDTAIEALKAGAFDFLTKP 100
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 4-103 5.47e-07

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 45.80  E-value: 5.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   4 LIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDIC-SAFSPSHFLVDLKLKDE-NGLTLIKPMRQQFPRSRIILLTGF 81
Cdd:cd18161     2 LVVEDDPDVRRLTAEVLEDLGYTVLEAASGDEALDLLeSGPDIDLLVTDVIMPGGmNGSQLAEEARRRRPDLKVLLTSGY 81

                          90       100
                  ....*....|....*....|...
gi 1053177719  82 ASiaSAVEAIRLGAD-DYLPKPV 103
Cdd:cd18161    82 AE--NAIEGGDLAPGvDVLSKPF 102
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 1-109 8.86e-07

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 45.51  E-value: 8.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDD-INLA--NTLARRftkHGFCCQLAHSC-QQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSR-- 74
Cdd:cd17551     1 MRILIVDDNpTNLLllEALLRS---AGYLEVVSFTDpREALAWCRENPPDLILLDYMMPGMDGLEFIRRLRALPGLEDvp 77

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1053177719  75 IILLTGFASIASAVEAIRLGADDYLPKPVDFVSLL 109
Cdd:cd17551    78 IVMITADTDREVRLRALEAGATDFLTKPFDPVELL 112
PRK10766 PRK10766
two-component system response regulator TorR;
2-113 1.85e-06

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 46.18  E-value: 1.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   2 NLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQqfpRSR--IILLT 79
Cdd:PRK10766    4 HILVVEDEPVTRARLQGYFEQEGYTVSEAASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELRS---RSTvgIILVT 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1053177719  80 GFASIASAVEAIRLGADDYLPKPVDfvslLRTLL 113
Cdd:PRK10766   81 GRTDSIDRIVGLEMGADDYVTKPLE----LRELL 110
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
 1-136 2.10e-06

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 46.17  E-value: 2.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MN-LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPrSRIILLT 79
Cdd:PRK10701    1 MNkIVFVEDDAEVGSLIAAYLAKHDIDVTVEPRGDRAEATILREQPDLVLLDIMLPGKDGMTICRDLRPKWQ-GPIVLLT 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719  80 GFASIASAVEAIRLGADDYLPK---PVDFVSLLRTLLEGSEAEQPTHTLPQTQIMSPERL 136
Cdd:PRK10701   80 SLDSDMNHILALEMGACDYILKttpPAVLLARLRLHLRQNEQATQTKGLQETSLTPYKAL 139
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 3-102 4.29e-06

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 43.34  E-value: 4.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQqfpRSR--IILLTG 80
Cdd:cd17621     1 VLVVEDEESFSDPLAYLLRKEGFEVTVATDGPAALAEFDRAGADIVLLDLMLPGLSGTEVCRQLRA---RSNvpVIMVTA 77

                          90       100
                  ....*....|....*....|..
gi 1053177719  81 FASIASAVEAIRLGADDYLPKP 102
Cdd:cd17621    78 KDSEIDKVVGLELGADDYVTKP 99
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 1-105 5.82e-06

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 43.36  E-value: 5.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTG 80
Cdd:cd17554     1 KKILVVDDEENIRELYKEELEDEGYEVVTAGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDLPVIICTA 80

                          90       100
                  ....*....|....*....|....*
gi 1053177719  81 FASIASavEAIRLGADDYLPKPVDF 105
Cdd:cd17554    81 YSEYKS--DFSSWAADAYVVKSSDL 103
PRK15369 PRK15369
two component system response regulator;
40-171 7.74e-06

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 44.30  E-value: 7.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719  40 CSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFASIASAVEAIRLGADDYLPK---------PVDFVSLLR 110
Cdd:PRK15369   45 CRQLEPDIVILDLGLPGMNGLDVIPQLHQRWPAMNILVLTARQEEHMASRTLAAGALGYVLKkspqqillaAIQTVAVGK 124

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1053177719 111 TLLEGSEAEQPTHTLPQTQIMSPERLEWEHIQhVL------HRNHgNISE----TARQLNMHRRTLQRKLQ 171
Cdd:PRK15369  125 RYIDPALNREAILALLNADDTNPPLLTPRERQ-ILklitegYTNR-DIAEqlsiSIKTVETHRLNMMRKLD 193
pleD PRK09581
response regulator PleD; Reviewed
 2-104 8.85e-06

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 44.89  E-value: 8.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   2 NLLIIEDDI----NLANTLARRFTKhgfccQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQfPRSR--- 74
Cdd:PRK09581  157 RILLVDDDVsqaeRIANILKEEFRV-----VVVSDPSEALFNAAETNYDLVIVSANFENYDPLRLCSQLRSK-ERTRyvp 230

                          90       100       110
                  ....*....|....*....|....*....|
gi 1053177719  75 IILLTGFASIASAVEAIRLGADDYLPKPVD 104
Cdd:PRK09581  231 ILLLVDEDDDPRLVKALELGVNDYLMRPID 260
PRK13856 PRK13856
two-component response regulator VirG; Provisional
 2-113 1.33e-05

two-component response regulator VirG; Provisional


Pssm-ID: 172377 [Multi-domain]  Cd Length: 241  Bit Score: 44.03  E-value: 1.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   2 NLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGF 81
Cdd:PRK13856    3 HVLVIDDDVAMRHLIVEYLTIHAFKVTAVADSQQFNRVLASETVDVVVVDLNLGREDGLEIVRSLATKSDVPIIIISGDR 82

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1053177719  82 ASIASAVEAIRLGADDYLPKPV---DFVSLLRTLL 113
Cdd:PRK13856   83 LEEADKVVALELGATDFIAKPFgtrEFLARIRVAL 117
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 30-112 1.81e-05

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 43.48  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719  30 AHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFASIASAVEAIRLGADDYLPKPVDFVSLL 109
Cdd:PRK10651   38 ASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLSGRIVVFSVSNHEEDVVTALKRGADGYLLKDMEPEDLL 117


                  ...
gi 1053177719 110 RTL 112
Cdd:PRK10651  118 KAL 120
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 48-112 2.14e-05

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 41.75  E-value: 2.14e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1053177719  48 FLvDLKLKDENGLTLIKPMRQQFPRSRIILLTGFASIAsaVEAIRLGADDYLPKPVDFVSLLRTL 112
Cdd:cd17532    49 FL-DIQMPGLDGLELAKKLSKLAKPPLIVFVTAYDEYA--VEAFELNAVDYLLKPFSEERLAEAL 110
PRK13557 PRK13557
histidine kinase; Provisional
 3-115 2.22e-05

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 43.51  E-value: 2.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANtLARRFTK-HGFCCQLAHSCQQAIDICSafspSHFLVDLKLKD------ENGLTLIKPMRQQFPRSRI 75
Cdd:PRK13557  418 ILIVDDRPDVAE-LARMILEdFGYRTLVASNGREALEILD----SHPEVDLLFTDlimpggMNGVMLAREARRRQPKIKV 492

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1053177719  76 ILLTGFASiaSAVEaiRLGAD----DYLPKP---VDFVSLLRTLLEG 115
Cdd:PRK13557  493 LLTTGYAE--ASIE--RTDAGgsefDILNKPyrrAELARRVRMVLDG 535
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 1-102 2.24e-05

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 43.03  E-value: 2.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDDINLANTLARRFTKHGF---CCQLAhscQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIIL 77
Cdd:PRK11083    4 PTILLVEDEQAIADTLVYALQSEGFtveWFERG---LPALDKLRQQPPDLVILDVGLPDISGFELCRQLLAFHPALPVIF 80

                          90       100
                  ....*....|....*....|....*
gi 1053177719  78 LTGFASIASAVEAIRLGADDYLPKP 102
Cdd:PRK11083   81 LTARSDEVDRLVGLEIGADDYVAKP 105
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 3-102 2.48e-05

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 41.33  E-value: 2.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLV-DLKLKDENGLTLIKPMRQQFPRSRIILLTGF 81
Cdd:cd18160     2 ILLADDEPSVRKFIVTTLKKAGYAVTEAESGAEALEKLQQGKDIDIVVtDIVMPEMDGIELAREARKIDPDVKILFISGG 81

                          90       100
                  ....*....|....*....|.
gi 1053177719  82 ASIASAVEAIRLGADDYLPKP 102
Cdd:cd18160    82 AAAAPELLSDAVGDNATLKKP 102
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 2-109 4.21e-05

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 42.48  E-value: 4.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   2 NLLIIEDDINLantlaRRFTK---HGFCCQL--AHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQqFPRSRII 76
Cdd:PRK10529    3 NVLIVEDEQAI-----RRFLRtalEGDGMRVfeAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDLRQ-WSAIPVI 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1053177719  77 LLTGFASIASAVEAIRLGADDYLPKPVDFVSLL 109
Cdd:PRK10529   77 VLSARSEESDKIAALDAGADDYLSKPFGIGELQ 109
PRK11517 PRK11517
DNA-binding response regulator HprR;
1-161 5.06e-05

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 42.19  E-value: 5.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMR--QQFPrsrIILL 78
Cdd:PRK11517    1 MKILLIEDNQRTQEWVTQGLSEAGYVIDAVSDGRDGLYLALKDDYALIILDIMLPGMDGWQILQTLRtaKQTP---VICL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719  79 TGFASIASAVEAIRLGADDYLPKPVDFVSLLRTLlegsEAEQPTHTlPQTQIMSPERLEWEHIQHVLHRNHGNISETARQ 158
Cdd:PRK11517   78 TARDSVDDRVRGLDSGANDYLVKPFSFSELLARV----RAQLRQHH-ALNSTLEISGLRMDSVSQSVSRDNISITLTRKE 152


                  ...
gi 1053177719 159 LNM 161
Cdd:PRK11517  153 FQL 155
REC_WspR-like cd17575
phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The ...
 31-110 6.29e-05

phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The GGDEF response regulator WspR is part of the Wsp system that is homologous to chemotaxis systems and also includes the membrane-bound receptor protein WspA. In response to growth on surfaces, WspR is phosphorylated by the Wsp signal transduction complex and is activated, functioning as a diguanylate cyclase (DGC) that catalyzes c-di-GMP synthesis. WspR is a hybrid response regulator-diguanylate cyclase, containing an N-terminal REC domain and a C-terminal GGDEF domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381117 [Multi-domain]  Cd Length: 128  Bit Score: 40.85  E-value: 6.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719  31 HSCQ---QAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQfPRSR---IILLTGFASIASAVEAIRLGADDY---LPK 101
Cdd:cd17575    29 HYCSdptEAIEVASQIKPTVILQDLVMPGVDGLTLVRFFRAN-PATRdipIIVLSTKEEPEVKSEAFALGANDYlvkLPD 107


                  ....*....
gi 1053177719 102 PVDFVSLLR 110
Cdd:cd17575   108 KIELVARIR 116
pleD PRK09581
response regulator PleD; Reviewed
 30-109 7.76e-05

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 42.20  E-value: 7.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719  30 AHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQfPRSR---IILLTGFASIASAVEAIRLGADDYLPKPVDFV 106
Cdd:PRK09581   32 ASSGAEAIAICEREQPDIILLDVMMPGMDGFEVCRRLKSD-PATThipVVMVTALDDPEDRVRGLEAGADDFLTKPINDV 110


                  ...
gi 1053177719 107 SLL 109
Cdd:PRK09581  111 ALF 113
PRK11173 PRK11173
two-component response regulator; Provisional
 2-172 7.89e-05

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 41.54  E-value: 7.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   2 NLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQfPRSRIILLTGF 81
Cdd:PRK11173    5 HILIVEDELVTRNTLKSIFEAEGYDVFEATDGAEMHQILSENDINLVIMDINLPGKNGLLLARELREQ-ANVALMFLTGR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719  82 ASIASAVEAIRLGADDYLPKPVDFVSL--------LRTLLEGSEAEQPTHT-----------LPQTQIMSPE-------R 135
Cdd:PRK11173   84 DNEVDKILGLEIGADDYITKPFNPRELtirarnllSRTMNLGTVSEERRSVesykfngweldINSRSLISPDgeqyklpR 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1053177719 136 LEWEHIQHVLhRNHGNISE--------TARQLNMHRRTLQ---RKLQK 172
Cdd:PRK11173  164 SEFRAMLHFC-ENPGKIQSraellkkmTGRELKPHDRTVDvtiRRIRK 210
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 3-109 1.02e-04

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 40.00  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQfPRSR---IILLT 79
Cdd:cd17598     1 ILIVEDSPTQAEQLKHILEEQGYKVQVARNGREALAMLAEHRPTLVISDIVMPEMDGYELCRKIKSD-PDLKdipVILLT 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 1053177719  80 GFASIASAVEAIRLGADDYLPKPVDFVSLL 109
Cdd:cd17598    80 TLSDPRDVIRGLECGADNFITKPYDEKYLL 109
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 2-112 1.38e-04

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 39.71  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   2 NLLIIEDDINLANTLARRFTKHGFCCQL--AHSCQQAIDI-----CSAFSPSHFLV--DLKLKDENGLTLIKPMRQQfPR 72
Cdd:cd17557     1 TILLVEDNPGDAELIQEAFKEAGVPNELhvVRDGEEALDFlrgegEYADAPRPDLIllDLNMPRMDGFEVLREIKAD-PD 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1053177719  73 SR---IILLTgfASIASA--VEAIRLGADDYLPKPVDFVSLLRTL 112
Cdd:cd17557    80 LRripVVVLT--TSDAEEdiERAYELGANSYIVKPVDFEEFVEAI 122
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
30-116 1.51e-04

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 40.61  E-value: 1.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719  30 AHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFASIASAVEAIRLGADDYLPKPVDFVSLL 109
Cdd:PRK10403   38 AGDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTVSDASSDVFALIDAGADGYLLKDSDPEVLL 117


                  ....*..
gi 1053177719 110 RTLLEGS 116
Cdd:PRK10403  118 EAIRAGA 124
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 1-54 1.56e-04

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 37.93  E-value: 1.56e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1053177719    1 MNLLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKL 54
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLKEEKPDLILLDIMM 54
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 49-102 2.33e-04

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 39.04  E-value: 2.33e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1053177719  49 LVDLKLKDENGLTLIKPMRQQFPRSR--IILLTGFASIASAVEAIRLGADDYLPKP 102
Cdd:cd17544    50 ITDYNMPEMDGFELVREIRKKYSRDQlaIIGISASGDNALSARFIKAGANDFLTKP 105
REC_TrxB cd17595
phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase ...
 3-104 2.34e-04

phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase output domain; This family is composed of uncharacterized fusion proteins containing a REC domain and a thioredoxin reductase domain. Thioredoxin reductase catalyzes the reduction of thioredoxin and is thus a central component in the thioredoxin system. Fusion proteins containing REC and thioredoxin reductase domains could play an important role in the environmental regulation of the cellular dithiol-disulfide ratio. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381126 [Multi-domain]  Cd Length: 135  Bit Score: 39.24  E-value: 2.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKH---GFCCQLAHSCQQAIDICSAFSPSH-----FLVDLKLKDENGLTLIKPMRQQFPRSR 74
Cdd:cd17595     3 ILTVDDDPQVLRAVARDLRRQygkDYRVLRADSGAEALDALKELKLRGeavalFLVDQRMPEMDGVEFLEKAMELFPEAK 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1053177719  75 IILLTGFASIASAVEAIR-LGADDYLPKPVD 104
Cdd:cd17595    83 RVLLTAYADTDAAIRAINdVQLDYYLLKPWD 113
CdaR COG3835
Sugar diacid utilization regulator CdaR [Transcription, Signal transduction mechanisms];
147-172 2.41e-04

Sugar diacid utilization regulator CdaR [Transcription, Signal transduction mechanisms];


Pssm-ID: 443046 [Multi-domain]  Cd Length: 301  Bit Score: 40.40  E-value: 2.41e-04
                          10        20
                  ....*....|....*....|....*.
gi 1053177719 147 RNHGNISETARQLNMHRRTLQRKLQK 172
Cdd:COG3835   248 ENNGNISETAEALFIHRNTLRYRLKK 273
Fis COG2901
DNA-binding protein Fis (factor for inversion stimulation) [Transcription];
141-172 4.51e-04

DNA-binding protein Fis (factor for inversion stimulation) [Transcription];


Pssm-ID: 442146 [Multi-domain]  Cd Length: 83  Bit Score: 37.49  E-value: 4.51e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1053177719 141 IQHVLHRNHGNISETARQLNMHRRTLQRKLQK 172
Cdd:COG2901    48 LETVLEHTRGNQSRAAEMLGINRNTLRKKLKQ 79
PRK10693 PRK10693
two-component system response regulator RssB;
29-114 4.74e-04

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 39.59  E-value: 4.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719  29 LAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFASIASAVEAIRLGADDYLPKPV-DFVS 107
Cdd:PRK10693    2 LAANGVDALELLGGFTPDLIICDLAMPRMNGIEFVEHLRNRGDQTPVLVISATENMADIAKALRLGVQDVLLKPVkDLNR 81


                  ....*..
gi 1053177719 108 LLRTLLE 114
Cdd:PRK10693   82 LREMVFA 88
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 3-103 7.54e-04

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 37.11  E-value: 7.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIeDDI--NLAnTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQfPRSR---IIL 77
Cdd:cd19920     1 ILIV-DDVpdNLR-LLSELLRAAGYRVLVATDGQQALQRAQAEPPDLILLDVMMPGMDGFEVCRRLKAD-PATRhipVIF 77

                          90       100
                  ....*....|....*....|....*.
gi 1053177719  78 LTGFASIASAVEAIRLGADDYLPKPV 103
Cdd:cd19920    78 LTALTDTEDKVKGFELGAVDYITKPF 103
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 3-113 8.50e-04

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 38.51  E-value: 8.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRqQFPRSRIILLTgfa 82
Cdd:PRK10710   13 ILIVEDEPKLGQLLIDYLQAASYATTLLSHGDEVLPYVRQTPPDLILLDLMLPGTDGLTLCREIR-RFSDIPIVMVT--- 88

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1053177719  83 siASAVEAIRL-----GADDYLPKPV---DFVSLLRTLL 113
Cdd:PRK10710   89 --AKIEEIDRLlgleiGADDYICKPYsprEVVARVKTIL 125
HTH_30 pfam13556
PucR C-terminal helix-turn-helix domain; This helix-turn-helix domain is often found at the ...
 147-172 8.52e-04

PucR C-terminal helix-turn-helix domain; This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Swiss:O32138 and is likely to be DNA-binding.


Pssm-ID: 433305 [Multi-domain]  Cd Length: 56  Bit Score: 35.89  E-value: 8.52e-04
                          10        20
                  ....*....|....*....|....*.
gi 1053177719 147 RNHGNISETARQLNMHRRTLQRKLQK 172
Cdd:pfam13556   7 ENGGNISATARALHVHRNTLRYRLRR 32
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 1-112 1.27e-03

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 37.01  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   1 MNLLIIEDDINLANTLARRFTKHGF-CCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPrSRIILLT 79
Cdd:cd19932     1 VRVLIAEDEALIRMDLREMLEEAGYeVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENI-APIVLLT 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1053177719  80 GFASIASAVEAIRLGADDYLPKPVDFVSLLRTL 112
Cdd:cd19932    80 AYSQQDLVERAKEAGAMAYLVKPFSESDLIPAI 112
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 34-114 2.65e-03

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 36.10  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719  34 QQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFASIASAVEAIRLGADDYLPK---PVDFVSLLR 110
Cdd:cd19930    34 QEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREELPDTKVLIVTTFGRPGYFRRALAAGVDGYVLKdrpIEELADAIR 113


                  ....
gi 1053177719 111 TLLE 114
Cdd:cd19930   114 TVHA 117
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
3-102 3.13e-03

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 37.01  E-value: 3.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPM-RQQFPRS-RIILLTG 80
Cdd:PRK10161    5 ILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLkRESMTRDiPVVMLTA 84

                          90       100
                  ....*....|....*....|..
gi 1053177719  81 FASIASAVEAIRLGADDYLPKP 102
Cdd:PRK10161   85 RGEEEDRVRGLETGADDYITKP 106
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 34-108 3.60e-03

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 35.83  E-value: 3.60e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1053177719  34 QQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRsRIILLTGFASIASAV--EAIRLGADDYLPKPVDFVSL 108
Cdd:cd17541    36 EEALEKIKELKPDVITLDIEMPVMDGLEALRRIMAERPT-PVVMVSSLTEEGAEItlEALELGAVDFIAKPSGGISL 111
REC_RitR-like cd19922
receiver (REC) domain of orphan response regulator RitR and similar domains; Streptococcus ...
 3-103 5.25e-03

receiver (REC) domain of orphan response regulator RitR and similar domains; Streptococcus pneumoniae RitR (Repressor of iron transport Regulator, formerly RR489) is an orphan two-component signal transduction response regulator that is required for lung pathogenicity. It acts to repress iron uptake via binding the pneumococcal iron uptake (Piu) transporter promoter. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. However, members of this family do not contain the phosphorylatable aspartic acid residue and are phosphorylation-independent.


Pssm-ID: 381149 [Multi-domain]  Cd Length: 110  Bit Score: 35.15  E-value: 5.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   3 LLIIEDDINLANTLARRFTKHGFCCQLAHSCQQAIDICSAFSPSHFLVDLKLKDENGLTLIKPMRQQFPRSRIILLTGFA 82
Cdd:cd19922     1 ILLLEKERNLAHFLSLELQKEGYRVDLVETGQEALSLALETDYDLILLNVNLSDMSAQDFAEKLSRIKPASVIIVLDHWE 80

                          90       100
                  ....*....|....*....|.
gi 1053177719  83 SIASAVEAIRLGADDYLPKPV 103
Cdd:cd19922    81 DLQEELEEVQRFAVSYVVKPV 101
REC_TPR cd17589
phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...
 4-112 7.04e-03

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.


Pssm-ID: 381123 [Multi-domain]  Cd Length: 115  Bit Score: 34.93  E-value: 7.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719   4 LIIEDdinlaNTLARRFTKH-----GFC-CQLAHSCQQAIDICSAFSPSHFLVDLKL-KDENGLTLIKPMR--QQFPRSR 74
Cdd:cd17589     2 LIVDD-----QPTFRSMLKSmlrslGVTrIDTASSGEEALRMCENKTYDIVLCDYNLgKGKNGQQLLEELRhkKLISPST 76

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1053177719  75 I-ILLTGFASIASAVEAIRLGADDYLPKPVDFVSLLRTL 112
Cdd:cd17589    77 VfIMVTGESSRAMVLSALELEPDDYLLKPFTVSELRERL 115
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 35-102 9.61e-03

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 34.27  E-value: 9.61e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1053177719  35 QAIDICSAFSPSHFLVDLKLKDENGLTLIKPMR--QQFPRSRIILLTGFASIASAVEAIRLGADDYLPKP 102
Cdd:cd17602    33 RALTTLLNSKPDLILIDIDMPDLDGYELCSLLRksSALKDTPIIMLTGKDGLVDRIRAKMAGASGYLTKP 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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